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Aliases for COPZ1 Gene

Aliases for COPZ1 Gene

  • Coatomer Protein Complex, Subunit Zeta 1 2 3
  • COPZ 3 4 6
  • Zeta-1-Coat Protein 3 4
  • Zeta-1 COP 3 4
  • Coatomer Protein Complex, Subunit Zeta 2
  • Coatomer Subunit Zeta-1 3
  • Zeta1-COP 3
  • Zeta-COP 3
  • CGI-120 3
  • HSPC181 3

External Ids for COPZ1 Gene

Previous HGNC Symbols for COPZ1 Gene

  • COPZ

Previous GeneCards Identifiers for COPZ1 Gene

  • GC12P054846
  • GC12U900056
  • GC12P053005
  • GC12P054718
  • GC12P051758

Summaries for COPZ1 Gene

Entrez Gene Summary for COPZ1 Gene

  • This gene encodes a subunit of the cytoplasmic coatamer protein complex, which is involved in autophagy and intracellular protein trafficking. The coatomer protein complex is comprised of seven subunits and functions as the coat protein of coat protein complex (COP)I-vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

GeneCards Summary for COPZ1 Gene

COPZ1 (Coatomer Protein Complex, Subunit Zeta 1) is a Protein Coding gene. Among its related pathways are COPI Mediated Transport and COPI Mediated Transport.

UniProtKB/Swiss-Prot for COPZ1 Gene

  • The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).

  • The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex

Gene Wiki entry for COPZ1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COPZ1 Gene

Genomics for COPZ1 Gene

Regulatory Elements for COPZ1 Gene

Transcription factor binding sites by QIAGEN in the COPZ1 gene promoter:

Genomic Location for COPZ1 Gene

Start:
54,301,202 bp from pter
End:
54,351,851 bp from pter
Size:
50,650 bases
Orientation:
Plus strand

Genomic View for COPZ1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COPZ1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COPZ1 Gene

Proteins for COPZ1 Gene

  • Protein details for COPZ1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61923-COPZ1_HUMAN
    Recommended name:
    Coatomer subunit zeta-1
    Protein Accession:
    P61923
    Secondary Accessions:
    • B4DDX8
    • B4DHZ0
    • F8VS17
    • F8VWL5
    • Q549N6
    • Q9Y3C3

    Protein attributes for COPZ1 Gene

    Size:
    177 amino acids
    Molecular mass:
    20198 Da
    Quaternary structure:
    • Oligomeric complex that consists of at least the alpha, beta, beta, gamma, delta, epsilon and zeta subunits.

    Three dimensional structures from OCA and Proteopedia for COPZ1 Gene

    Alternative splice isoforms for COPZ1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COPZ1 Gene

Proteomics data for COPZ1 Gene at MOPED

Post-translational modifications for COPZ1 Gene

  • Ubiquitination at Lys29, Lys39, Lys46, Lys51, Lys168, and Lys172
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for COPZ1 Gene

Domains for COPZ1 Gene

Protein Domains for COPZ1 Gene

Graphical View of Domain Structure for InterPro Entry

P61923

UniProtKB/Swiss-Prot:

COPZ1_HUMAN :
  • P61923
Family:
  • Belongs to the adaptor complexes small subunit family.
genes like me logo Genes that share domains with COPZ1: view

No data available for Gene Families for COPZ1 Gene

Function for COPZ1 Gene

Molecular function for COPZ1 Gene

UniProtKB/Swiss-Prot Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).
UniProtKB/Swiss-Prot Function: The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex
genes like me logo Genes that share phenotypes with COPZ1: view

miRNA for COPZ1 Gene

miRTarBase miRNAs that target COPZ1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for COPZ1 Gene

Localization for COPZ1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COPZ1 Gene

Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COPZ1 Gene COMPARTMENTS Subcellular localization image for COPZ1 gene
Compartment Confidence
golgi apparatus 5
cytosol 4
cytoskeleton 3
nucleus 1

Gene Ontology (GO) - Cellular Components for COPZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0016020 membrane --
GO:0030117 membrane coat --
GO:0030126 COPI vesicle coat ISS --
genes like me logo Genes that share ontologies with COPZ1: view

Pathways for COPZ1 Gene

genes like me logo Genes that share pathways with COPZ1: view

Gene Ontology (GO) - Biological Process for COPZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006886 intracellular protein transport IEA --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS 11030615
GO:0006891 intra-Golgi vesicle-mediated transport ISS --
GO:0015031 protein transport --
genes like me logo Genes that share ontologies with COPZ1: view

Compounds for COPZ1 Gene

(1) HMDB Compounds for COPZ1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with COPZ1: view

Transcripts for COPZ1 Gene

Unigene Clusters for COPZ1 Gene

Coatomer protein complex, subunit zeta 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COPZ1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - -
SP7: -
SP8: -

Relevant External Links for COPZ1 Gene

GeneLoc Exon Structure for
COPZ1
ECgene alternative splicing isoforms for
COPZ1

Expression for COPZ1 Gene

mRNA expression in normal human tissues for COPZ1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COPZ1 Gene

SOURCE GeneReport for Unigene cluster for COPZ1 Gene Hs.505652

genes like me logo Genes that share expressions with COPZ1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for COPZ1 Gene

Orthologs for COPZ1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for COPZ1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COPZ1 35
  • 99.81 (n)
  • 100 (a)
COPZ1 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia COPZ1 35
  • 96.88 (n)
  • 99.42 (a)
COPZ1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COPZ1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Copz1 35
  • 92.98 (n)
  • 100 (a)
Copz1 16
Copz1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Copz1 35
  • 92.01 (n)
  • 100 (a)
lizard
(Anolis carolinensis)
Reptilia COPZ1 36
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.22784 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75577 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9606 35
zebrafish
(Danio rerio)
Actinopterygii copz1 35
  • 80.31 (n)
  • 94.15 (a)
copz1 36
  • 83 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006522 35
  • 66.28 (n)
  • 63.79 (a)
fruit fly
(Drosophila melanogaster)
Insecta zetaCOP 35
  • 64.44 (n)
  • 63.03 (a)
zetaCOP 36
  • 60 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea copz-1 36
  • 53 (a)
OneToOne
F59E10.3 35
  • 59.02 (n)
  • 56.47 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL016C 35
  • 51.93 (n)
  • 39.86 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RET3 35
  • 50.68 (n)
  • 42.47 (a)
RET3 36
  • 34 (a)
OneToMany
RET3 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F27313g 35
  • 48.43 (n)
  • 42.77 (a)
rice
(Oryza sativa)
Liliopsida Os05g0461000 35
  • 54.76 (n)
  • 43.45 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02538 35
  • 51.31 (n)
  • 43.03 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ret3 35
  • 52.04 (n)
  • 43.88 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3964 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5770 36
  • 68 (a)
OneToOne
Species with no ortholog for COPZ1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for COPZ1 Gene

ENSEMBL:
Gene Tree for COPZ1 (if available)
TreeFam:
Gene Tree for COPZ1 (if available)

Paralogs for COPZ1 Gene

genes like me logo Genes that share paralogs with COPZ1: view

No data available for Paralogs for COPZ1 Gene

Variants for COPZ1 Gene

Sequence variations from dbSNP and Humsavar for COPZ1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs7176 -- 54,351,741(+) ATAAC(A/G/T)GGGCA utr-variant-3-prime, nc-transcript-variant
rs12705 -- 54,351,532(-) TCTCA(A/G)CGACC utr-variant-3-prime, nc-transcript-variant
rs1059675 -- 54,351,774(+) TAAAA(A/G/T)ATGCA utr-variant-3-prime, nc-transcript-variant
rs1059687 -- 54,351,798(+) AAACC(A/C)CCTTC utr-variant-3-prime, nc-transcript-variant
rs1059737 -- 54,350,646(+) TAAAT(C/T)TCCAT utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for COPZ1 Gene

Variant ID Type Subtype PubMed ID
nsv520202 CNV Loss 19592680

Relevant External Links for COPZ1 Gene

HapMap Linkage Disequilibrium report
COPZ1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COPZ1 Gene

Disorders for COPZ1 Gene

(1) University of Copenhagen DISEASES for COPZ1 Gene

genes like me logo Genes that share disorders with COPZ1: view

No data available for UniProtKB/Swiss-Prot for COPZ1 Gene

Publications for COPZ1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Solution structure of human zeta-COP: direct evidences for structural similarity between COP I and clathrin-adaptor coats. (PMID: 19167404) Yu W. … Xia B. (J. Mol. Biol. 2009) 3 4
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  4. Identification and characterization of novel isoforms of COP I subunits. (PMID: 11056392) Futatsumori M. … Nakayama K. (J. Biochem. 2000) 3 4
  5. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 3 4

Products for COPZ1 Gene

Sources for COPZ1 Gene

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