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Aliases for COPS9 Gene

Aliases for COPS9 Gene

  • COP9 Signalosome Subunit 9 2 3 5
  • Myeloma Overexpressed 2 2 3
  • CSN Acidic Protein 2 3
  • MYEOV2 3 4
  • Myeloma-Overexpressed Gene 2 Protein 3
  • Helicase/Primase Complex Protein 3
  • CSNAP 3

External Ids for COPS9 Gene

Previous HGNC Symbols for COPS9 Gene

  • MYEOV2

Summaries for COPS9 Gene

GeneCards Summary for COPS9 Gene

COPS9 (COP9 Signalosome Subunit 9) is a Protein Coding gene. Diseases associated with COPS9 include Myeloma.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COPS9 Gene

Genomics for COPS9 Gene

Regulatory Elements for COPS9 Gene

Enhancers for COPS9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around COPS9 on UCSC Golden Path with GeneCards custom track

Promoters for COPS9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for COPS9 Gene

240,126,563 bp from pter
240,136,807 bp from pter
10,245 bases
Minus strand

Genomic View for COPS9 Gene

Genes around COPS9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COPS9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COPS9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COPS9 Gene

Proteins for COPS9 Gene

  • Protein details for COPS9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Myeloma-overexpressed gene 2 protein
    Protein Accession:
    Secondary Accessions:
    • Q8N110

    Protein attributes for COPS9 Gene

    57 amino acids
    Molecular mass:
    6211 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for COPS9 Gene


neXtProt entry for COPS9 Gene

Post-translational modifications for COPS9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for COPS9 Gene

No data available for DME Specific Peptides for COPS9 Gene

Domains & Families for COPS9 Gene

Protein Domains for COPS9 Gene


Suggested Antigen Peptide Sequences for COPS9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MYEOV2 family.
  • Belongs to the MYEOV2 family.
genes like me logo Genes that share domains with COPS9: view

No data available for Gene Families for COPS9 Gene

Function for COPS9 Gene

genes like me logo Genes that share phenotypes with COPS9: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for COPS9 Gene

Localization for COPS9 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for COPS9 Gene

Pathways & Interactions for COPS9 Gene

SuperPathways for COPS9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for COPS9 Gene


No data available for Pathways by source and SIGNOR curated interactions for COPS9 Gene

Drugs & Compounds for COPS9 Gene

No Compound Related Data Available

Transcripts for COPS9 Gene

Unigene Clusters for COPS9 Gene

Myeloma overexpressed 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COPS9 Gene

No ASD Table

Relevant External Links for COPS9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COPS9 Gene

NURSA nuclear receptor signaling pathways regulating expression of COPS9 Gene:


SOURCE GeneReport for Unigene cluster for COPS9 Gene:

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for COPS9 Gene

Orthologs for COPS9 Gene

This gene was present in the common ancestor of animals.

Orthologs for COPS9 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MYEOV2 34
  • 93.57 (n)
  • 100 (a)
  • 81 (a)
(Canis familiaris)
Mammalia MYEOV2 34
  • 94.15 (n)
  • 100 (a)
  • 92 (a)
(Pan troglodytes)
Mammalia MYEOV2 35
  • 97 (a)
  • 98.83 (n)
  • 100 (a)
(Mus musculus)
Mammalia Myeov2 35
  • 96 (a)
Myeov2 16
Myeov2 34
  • 90.64 (n)
  • 98.25 (a)
(Monodelphis domestica)
Mammalia MYEOV2 35
  • 48 (a)
(Rattus norvegicus)
Mammalia Myeov2 34
  • 89.47 (n)
  • 98.25 (a)
(Gallus gallus)
Aves MYEOV2 35
  • 81 (a)
  • 87.13 (n)
  • 100 (a)
(Anolis carolinensis)
Reptilia MYEOV2 35
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia myeov2 34
  • 83.04 (n)
  • 98.25 (a)
(Danio rerio)
Actinopterygii zgc77808 34
myeov2 35
  • 95 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17059 35
  • 46 (a)
Species where no ortholog for COPS9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COPS9 Gene

Gene Tree for COPS9 (if available)
Gene Tree for COPS9 (if available)

Paralogs for COPS9 Gene Pseudogenes for COPS9 Gene

genes like me logo Genes that share paralogs with COPS9: view

No data available for Paralogs for COPS9 Gene

Variants for COPS9 Gene

Sequence variations from dbSNP and Humsavar for COPS9 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs6704704 -- 240,130,236(+) TGAGG(G/T)GCTTT intron-variant
rs4528788 -- 240,134,749(-) AGGAG(A/G)CTGAG intron-variant
rs12621732 -- 240,134,079(+) GGGCC(A/G)CTACC intron-variant
rs7605040 -- 240,126,131(+) ctttg(C/G)gaaat downstream-variant-500B
rs7605352 -- 240,128,740(+) AGTCC(A/G)ATCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COPS9 Gene

Variant ID Type Subtype PubMed ID
nsv997288 CNV gain 25217958

Variation tolerance for COPS9 Gene

Residual Variation Intolerance Score: 50.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.39; 42.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COPS9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COPS9 Gene

Disorders for COPS9 Gene

MalaCards: The human disease database

(1) MalaCards diseases for COPS9 Gene - From: GeneCards

Disorder Aliases PubMed IDs
  • multiple myeloma
- elite association - COSMIC cancer census association via MalaCards
Search COPS9 in MalaCards View complete list of genes associated with diseases

Relevant External Links for COPS9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with COPS9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for COPS9 Gene

Publications for COPS9 Gene

  1. CSNAP Is a Stoichiometric Subunit of the COP9 Signalosome. (PMID: 26456823) Rozen S. … Sharon M. (Cell Rep 2015) 2 3 65
  2. Myeloma overexpressed 2 (Myeov2) regulates L11 subnuclear localization through Nedd8 modification. (PMID: 23776465) Ebina M. … Chiba T. (PLoS ONE 2013) 2 3 65
  3. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 3 65
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 65

Products for COPS9 Gene

Sources for COPS9 Gene

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