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Aliases for COPS9 Gene

Aliases for COPS9 Gene

  • COP9 Signalosome Subunit 9 2 3 5
  • CSN Acidic Protein 2 3 4
  • Myeloma-Overexpressed Gene 2 Protein 3 4
  • Myeloma Overexpressed 2 2 3
  • MYEOV2 3 4
  • CSNAP 3 4
  • COP9 Signalosome Complex Subunit 9 3
  • Helicase/Primase Complex Protein 3

External Ids for COPS9 Gene

Previous HGNC Symbols for COPS9 Gene

  • MYEOV2

Summaries for COPS9 Gene

GeneCards Summary for COPS9 Gene

COPS9 (COP9 Signalosome Subunit 9) is a Protein Coding gene.

UniProtKB/Swiss-Prot for COPS9 Gene

  • Isoform 1: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Plays a role in cell proliferation.

  • Isoform 2: Negatively regulates neddylation of proteins, including ribosoaml protein RPL11.

Additional gene information for COPS9 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COPS9 Gene

Genomics for COPS9 Gene

Regulatory Elements for COPS9 Gene

Enhancers for COPS9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H240134 1 ENCODE 5.7 +0.9 866 2 HDGF ATF1 ARID4B SIN3A DMAP1 ETS1 ELK1 ZNF207 ZNF143 ATF7 ANKMY1 OR6B3 PRR21 NDUFA10 COPS9 OR5S1P
GH02H240200 0.4 ENCODE 10.7 -63.6 -63641 0 FOXP2 EZH2 COPS9 PRR21 GPC1 NDUFA10 OTOS LOC105373968
GH02H240201 0.4 ENCODE 10.3 -64.1 -64052 0 FOXP2 EZH2 COPS9 OTOS LOC105373968
GH02H240143 0.7 ENCODE 0.4 -7.2 -7162 0 CTCF ZNF654 TRIM22 REST ZBTB8A RAD21 ZFP69B HIC1 MIER3 GATAD1 OTOS COPS9
GH02H240140 0.2 ENCODE 0.7 -3.3 -3282 0 COPS9 OTOS
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around COPS9 on UCSC Golden Path with GeneCards custom track

Promoters for COPS9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000133105 507 1401 HDGF ARID4B SIN3A DMAP1 ETS1 ELK1 ZNF207 ZNF143 ATF7 ZHX2

Genomic Location for COPS9 Gene

Chromosome:
2
Start:
240,126,563 bp from pter
End:
240,136,807 bp from pter
Size:
10,245 bases
Orientation:
Minus strand

Genomic View for COPS9 Gene

Genes around COPS9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COPS9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COPS9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COPS9 Gene

Proteins for COPS9 Gene

  • Protein details for COPS9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXC6-CSN9_HUMAN
    Recommended name:
    COP9 signalosome complex subunit 9
    Protein Accession:
    Q8WXC6
    Secondary Accessions:
    • Q8N110

    Protein attributes for COPS9 Gene

    Size:
    57 amino acids
    Molecular mass:
    6211 Da
    Quaternary structure:
    • Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 isoform 1. In the complex, it interacts directly with COPS3, COPS5 and COPS6 (PubMed:26456823). Isoform 2 associates with CSN complex (PubMed:23776465). Isoform 2 interacts with COPS5, CUL1, CUL3 and RPL11 (PubMed:23776465). According to PubMed:26456823, does not associate with CSN complex.

    Alternative splice isoforms for COPS9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COPS9 Gene

Post-translational modifications for COPS9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for COPS9 Gene

No data available for DME Specific Peptides for COPS9 Gene

Domains & Families for COPS9 Gene

Gene Families for COPS9 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for COPS9 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for COPS9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WXC6

UniProtKB/Swiss-Prot:

CSN9_HUMAN :
  • Isoform 1: The Phe/Asp-rich domain at the C-terminus is necessary for its incorporation into the CSN complex.
  • Belongs to the CSN9 family.
Domain:
  • Isoform 1: The Phe/Asp-rich domain at the C-terminus is necessary for its incorporation into the CSN complex.
  • Isoform 2: Amino acids 60-89 in isoform 2 are necessary for interaction with COPS5, CUL1, CUL3.
Family:
  • Belongs to the CSN9 family.
genes like me logo Genes that share domains with COPS9: view

Function for COPS9 Gene

Molecular function for COPS9 Gene

UniProtKB/Swiss-Prot Function:
Isoform 1: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Plays a role in cell proliferation.
UniProtKB/Swiss-Prot Function:
Isoform 2: Negatively regulates neddylation of proteins, including ribosoaml protein RPL11.

Gene Ontology (GO) - Molecular Function for COPS9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 26456823
genes like me logo Genes that share ontologies with COPS9: view
genes like me logo Genes that share phenotypes with COPS9: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for COPS9
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for COPS9 Gene

Localization for COPS9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COPS9 Gene

Isoform 1: Nucleus. Cytoplasm. Nucleus, nucleoplasm. Note=Excluded from the nucleolus. Recruited to the nucleoplasm and chromatin following DNA damage induction. {ECO:0000269 PubMed:26456823}.
Isoform 2: Nucleus, nucleoplasm. Note=Excluded from the nucleolus. {ECO:0000269 PubMed:23776465}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for COPS9 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for COPS9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 26456823
GO:0005634 nucleus IDA,IEA 26456823
GO:0005654 nucleoplasm IDA,IEA 23776465
GO:0005737 cytoplasm IDA,IEA 26456823
GO:0008180 COP9 signalosome IEA,IDA 26456823
genes like me logo Genes that share ontologies with COPS9: view

Pathways & Interactions for COPS9 Gene

SuperPathways for COPS9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for COPS9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IMP 26456823
GO:0034644 cellular response to UV IDA 26456823
genes like me logo Genes that share ontologies with COPS9: view

No data available for Pathways by source and SIGNOR curated interactions for COPS9 Gene

Drugs & Compounds for COPS9 Gene

No Compound Related Data Available

Transcripts for COPS9 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for COPS9
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for COPS9 Gene

No ASD Table

Relevant External Links for COPS9 Gene

GeneLoc Exon Structure for
COPS9
ECgene alternative splicing isoforms for
COPS9

Expression for COPS9 Gene

NURSA nuclear receptor signaling pathways regulating expression of COPS9 Gene:

COPS9

Evidence on tissue expression from TISSUES for COPS9 Gene

  • Liver(4.3)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for COPS9 Gene

Orthologs for COPS9 Gene

This gene was present in the common ancestor of animals.

Orthologs for COPS9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYEOV2 34 33
  • 98.83 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MYEOV2 33 34
  • 94.15 (n)
cow
(Bos Taurus)
Mammalia MYEOV2 33 34
  • 93.57 (n)
mouse
(Mus musculus)
Mammalia Myeov2 33 34
  • 90.64 (n)
Cops9 16
rat
(Rattus norvegicus)
Mammalia Myeov2 33
  • 89.47 (n)
oppossum
(Monodelphis domestica)
Mammalia MYEOV2 34
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYEOV2 33 34
  • 87.13 (n)
lizard
(Anolis carolinensis)
Reptilia MYEOV2 34
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia myeov2 33
  • 83.04 (n)
zebrafish
(Danio rerio)
Actinopterygii myeov2 34
  • 95 (a)
OneToOne
zgc77808 33
fruit fly
(Drosophila melanogaster)
Insecta CG17059 34
  • 46 (a)
OneToOne
Species where no ortholog for COPS9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COPS9 Gene

ENSEMBL:
Gene Tree for COPS9 (if available)
TreeFam:
Gene Tree for COPS9 (if available)

Paralogs for COPS9 Gene

Pseudogenes.org Pseudogenes for COPS9 Gene

genes like me logo Genes that share paralogs with COPS9: view

No data available for Paralogs for COPS9 Gene

Variants for COPS9 Gene

Sequence variations from dbSNP and Humsavar for COPS9 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000063454 -- 240,129,307(+) ATAGG(C/T)ACGTG intron-variant
rs1000504538 -- 240,132,586(+) TTCCC(A/G)TCAGG intron-variant
rs1000667551 -- 240,128,236(+) TGCTG(C/G)AACCA intron-variant
rs1001238557 -- 240,134,708(+) GCCCT(G/T)GTTCC intron-variant
rs1001302797 -- 240,136,410(+) CCGGC(A/C)GCCGG upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for COPS9 Gene

Variant ID Type Subtype PubMed ID
nsv997288 CNV gain 25217958

Variation tolerance for COPS9 Gene

Residual Variation Intolerance Score: 50.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.39; 42.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COPS9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
COPS9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COPS9 Gene

Disorders for COPS9 Gene

Relevant External Links for COPS9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COPS9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COPS9

No disorders were found for COPS9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COPS9 Gene

Publications for COPS9 Gene

  1. CSNAP Is a Stoichiometric Subunit of the COP9 Signalosome. (PMID: 26456823) Rozen S … Sharon M (Cell reports 2015) 2 3 4 60
  2. Myeloma overexpressed 2 (Myeov2) regulates L11 subnuclear localization through Nedd8 modification. (PMID: 23776465) Ebina M … Chiba T (PloS one 2013) 2 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  5. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J … Shi Y (Genes & development 2015) 3 60

Products for COPS9 Gene

Sources for COPS9 Gene

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