Aliases for COPS9 Gene
External Ids for COPS9 Gene
Previous HGNC Symbols for COPS9 Gene
GeneCards Summary for COPS9 Gene
COPS9 (COP9 Signalosome Subunit 9) is a Protein Coding gene.
UniProtKB/Swiss-Prot for COPS9 Gene
Isoform 1: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Plays a role in cell proliferation.
Isoform 2: Negatively regulates neddylation of proteins, including ribosoaml protein RPL11.