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Aliases for COPS8 Gene

Aliases for COPS8 Gene

  • COP9 Signalosome Subunit 8 2 3
  • JAB1-Containing Signalosome Subunit 8 3 4
  • Signalosome Subunit 8 3 4
  • COP9 Homolog 3 4
  • HCOP9 3 4
  • CSN8 3 4
  • SGN8 3 4
  • COP9 Constitutive Photomorphogenic Homolog Subunit 8 (Arabidopsis) 2
  • COP9 Constitutive Photomorphogenic Homolog Subunit 8 3
  • COP9 Signalosome Complex Subunit 8 3
  • COP9 3

External Ids for COPS8 Gene

Previous GeneCards Identifiers for COPS8 Gene

  • GC02P238280
  • GC02P237776
  • GC02P237658
  • GC02P237993
  • GC02P229786

Summaries for COPS8 Gene

Entrez Gene Summary for COPS8 Gene

  • The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

GeneCards Summary for COPS8 Gene

COPS8 (COP9 Signalosome Subunit 8) is a Protein Coding gene.

UniProtKB/Swiss-Prot for COPS8 Gene

  • Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Gene Wiki entry for COPS8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COPS8 Gene

Genomics for COPS8 Gene

Regulatory Elements for COPS8 Gene

Genomic Location for COPS8 Gene

Start:
237,085,312 bp from pter
End:
237,100,466 bp from pter
Size:
15,155 bases
Orientation:
Plus strand

Genomic View for COPS8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COPS8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COPS8 Gene

Proteins for COPS8 Gene

  • Protein details for COPS8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99627-CSN8_HUMAN
    Recommended name:
    COP9 signalosome complex subunit 8
    Protein Accession:
    Q99627
    Secondary Accessions:
    • A8K1H6
    • Q53QS9

    Protein attributes for COPS8 Gene

    Size:
    209 amino acids
    Molecular mass:
    23226 Da
    Quaternary structure:
    • Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS3, COPS4 and COPS7 (COPS7A or COPS7B).

    Three dimensional structures from OCA and Proteopedia for COPS8 Gene

    Alternative splice isoforms for COPS8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COPS8 Gene

Proteomics data for COPS8 Gene at MOPED

Post-translational modifications for COPS8 Gene

  • Ubiquitination at Lys15, Lys65, and Lys178
  • Modification sites at PhosphoSitePlus

Other Protein References for COPS8 Gene

No data available for DME Specific Peptides for COPS8 Gene

Domains for COPS8 Gene

Protein Domains for COPS8 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q99627

UniProtKB/Swiss-Prot:

CSN8_HUMAN :
  • Q99627
Domain:
  • Contains 1 PCI domain.
Family:
  • Belongs to the CSN8 family.
genes like me logo Genes that share domains with COPS8: view

No data available for Gene Families for COPS8 Gene

Function for COPS8 Gene

Molecular function for COPS8 Gene

UniProtKB/Swiss-Prot Function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Gene Ontology (GO) - Molecular Function for COPS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with COPS8: view
genes like me logo Genes that share phenotypes with COPS8: view

Animal Models for COPS8 Gene

MGI Knock Outs for COPS8:

miRNA for COPS8 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for COPS8 Gene

Localization for COPS8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COPS8 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COPS8 Gene COMPARTMENTS Subcellular localization image for COPS8 gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for COPS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 8689678
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0008180 COP9 signalosome IDA 18850735
GO:0048471 perinuclear region of cytoplasm IDA 9535219
genes like me logo Genes that share ontologies with COPS8: view

Pathways for COPS8 Gene

SuperPathways for COPS8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for COPS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007250 activation of NF-kappaB-inducing kinase activity IMP 22992343
GO:0008285 negative regulation of cell proliferation IMP 23689509
GO:0010388 cullin deneddylation IDA 19141280
genes like me logo Genes that share ontologies with COPS8: view

No data available for Pathways by source for COPS8 Gene

Transcripts for COPS8 Gene

Unigene Clusters for COPS8 Gene

COP9 signalosome subunit 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COPS8 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11
SP1: - - -
SP2: - - - - - -
SP3: - -
SP4: - -
SP5: - -
SP6: - - - - - -
SP7: - - - - - -

Relevant External Links for COPS8 Gene

GeneLoc Exon Structure for
COPS8
ECgene alternative splicing isoforms for
COPS8

Expression for COPS8 Gene

mRNA expression in normal human tissues for COPS8 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COPS8 Gene

SOURCE GeneReport for Unigene cluster for COPS8 Gene Hs.531713

genes like me logo Genes that share expressions with COPS8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for COPS8 Gene

Orthologs for COPS8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for COPS8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COPS8 35
  • 99.68 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia COPS8 35
  • 89 (n)
  • 96.65 (a)
COPS8 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 98 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
COPS8 35
  • 91.39 (n)
  • 98.09 (a)
mouse
(Mus musculus)
Mammalia Cops8 35
  • 89.95 (n)
  • 95.22 (a)
Cops8 16
Cops8 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia COPS8 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COPS8 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cops8 35
  • 88.52 (n)
  • 95.69 (a)
chicken
(Gallus gallus)
Aves COPS8 35
  • 82.45 (n)
  • 88.89 (a)
COPS8 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COPS8 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.22566 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cops8 35
  • 75.13 (n)
  • 81.35 (a)
MGC76051 35
zebrafish
(Danio rerio)
Actinopterygii cops8 35
  • 68.24 (n)
  • 73.82 (a)
cops8 36
  • 73 (a)
OneToOne
zgc56319 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008857 35
  • 48.13 (n)
  • 39.64 (a)
fruit fly
(Drosophila melanogaster)
Insecta CSN8 35
  • 42.94 (n)
  • 29.94 (a)
CSN8 36
  • 30 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons COP9 35
  • 47.31 (n)
  • 34.41 (a)
rice
(Oryza sativa)
Liliopsida Os04g0428900 35
  • 45.62 (n)
  • 37.99 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6909 36
  • 34 (a)
OneToOne
Species with no ortholog for COPS8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COPS8 Gene

ENSEMBL:
Gene Tree for COPS8 (if available)
TreeFam:
Gene Tree for COPS8 (if available)

Paralogs for COPS8 Gene

Pseudogenes.org Pseudogenes for COPS8 Gene

genes like me logo Genes that share paralogs with COPS8: view

No data available for Paralogs for COPS8 Gene

Variants for COPS8 Gene

Sequence variations from dbSNP and Humsavar for COPS8 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs7485 -- 237,098,529(+) TTATC(C/G)CTTGG utr-variant-3-prime
rs1130553 -- 237,098,407(+) CTTGT(C/G)CTGTC utr-variant-3-prime
rs1137555 -- 237,087,790(+) agctg(A/G)gcatg intron-variant
rs1804621 -- 237,089,939(+) ACAAC(C/T)ATCAA reference, synonymous-codon
rs3088334 -- 237,085,956(+) GCCGG(C/G)CCGCG utr-variant-5-prime

Relevant External Links for COPS8 Gene

HapMap Linkage Disequilibrium report
COPS8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for COPS8 Gene

Disorders for COPS8 Gene

Relevant External Links for COPS8

Genetic Association Database (GAD)
COPS8
genes like me logo Genes that share disorders with COPS8: view

No data available for UniProtKB/Swiss-Prot for COPS8 Gene

Publications for COPS8 Gene

  1. The novel components of the Arabidopsis light signaling pathway may define a group of general developmental regulators shared by both animal and plant kingdoms. (PMID: 7634324) Chamovitz D.A. … Deng X.-W. (Cell 1995) 2 3 4
  2. The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. (PMID: 12732143) Groisman R. … Nakatani Y. (Cell 2003) 2 3 4
  3. A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. (PMID: 9535219) Seeger M. … Dubiel W. (FASEB J. 1998) 3 4 23
  4. Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. (PMID: 18850735) Fang L. … Huang L. (J. Proteome Res. 2008) 3 4
  5. Electron microscopy and subunit-subunit interaction studies reveal a first architecture of COP9 signalosome. (PMID: 10903862) Kapelari B. … Dubiel W. (J. Mol. Biol. 2000) 3 23

Products for COPS8 Gene

Sources for COPS8 Gene

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