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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

COPS8 Gene

protein-coding   GIFtS: 52
GCID: GC02P237993

COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)
 Explore 8 diseases affiliated with
COPS8 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for COPS8    

Aliases
for COPS8 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
COP9 Constitutive Photomorphogenic Homolog Subunit 8 (Arabidopsis)1 2     HCOP91
CSN81 2 3     JAB1-Containing Signalosome Subunit 82 3
SGN81 2 3     MGC12971
COP91 2     COP9 Signalosome Complex Subunit 82
Signalosome Subunit 82 3     MMMEP5
COP9 Homolog2 3     

External Ids:    HGNC: 243351   Entrez Gene: 109202   Ensembl: ENSG000001986127   OMIM: 6013495   UniProtKB: Q996273   

Export aliases for COPS8 gene to outside databases

Previous GC identifers: GC02P238280 GC02P237776 GC02P237658 GC02P229786


Summaries
for COPS8 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for COPS8:
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex
that functions as an important regulator in multiple signaling pathways. The structure and function of COP9
signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to
interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively
spliced transcript variants encoding distinct isoforms have been observed. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CSN8_HUMAN, Q99627
Function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental
processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the
deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of
SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN,
IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent
phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively

Gene Wiki entry for COPS8


Genomic Views
for COPS8 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005120.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the COPS8 gene promoter:
         USF1   p53   USF-1   HNF-3beta   NF-kappaB1   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): COPS8 promoter sequence
   Search SABiosciences Chromatin IP Primers for COPS8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COPS8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.3   Ensembl cytogenetic band:  2q37.3   HGNC cytogenetic band: 2q37.3

COPS8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COPS8 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P237993:  view genomic region     (about GC identifiers)

Start:
 237,993,955 bp from pter      End:
 238,009,109 bp from pter
Size:
 15,155 bases      Orientation:
 plus strand

Proteins
for COPS8 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CSN8_HUMAN, Q99627 (See protein sequence)
Recommended Name: COP9 signalosome complex subunit 8  
Size: 209 amino acids; 23226 Da
Subunit: Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or
COPS7B) and COPS8. In the complex, it probably interacts directly with COPS3, COPS4 and COPS7 (COPS7A or COPS7B)
Subcellular location: Cytoplasm. Nucleus
Secondary accessions: A8K1H6 Q53QS9
Alternative splicing: 2 isoforms:  Q99627-1   Q99627-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for COPS8: NX_Q99627

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q99627

    • COPS8 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_006701.1  NP_937832.1  

    ENSEMBL proteins: 
     ENSP00000346340   ENSP00000375865   ENSP00000387212   ENSP00000388655   ENSP00000386838  
     ENSP00000413696  

    Human Recombinant Protein Products: 
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    OriGene Purified Protein: COPS8
    OriGene Protein Over-expression Lysate (see all 2): COPS8
    OriGene Custom Protein Services for COPS8 
    GenScript Custom Purified and Recombinant Proteins Services for COPS8
    Novus Biologicals COPS8 Proteins
    Novus Biologicals COPS8 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for COPS8
    Uscn Proteins for COPS8

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0008180signalosome IDA18850735


    COPS8 for ontologies           About GeneDecksing



    COPS8 Antibody Products: 
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    Uscn ELISAs and CLIAs for COPS8

    Protein Domains /
    Families
    for COPS8 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    COPS8 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR019280 COP9_signalosome_subunit_CSN8

    Graphical View of Domain Structure for InterPro Entry Q99627

    ProtoNet protein and cluster: Q99627

    UniProtKB/Swiss-Prot: CSN8_HUMAN, Q99627
    Similarity: Belongs to the CSN8 family
    Similarity: Contains 1 PCI domain


    Function
    for COPS8 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CSN8_HUMAN, Q99627
    Function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental
    processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the
    deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of
    SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN,
    IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent
    phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COPS8
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate COPS8 (see all 12):
    hsa-miR-429 hsa-miR-7-2* hsa-miR-3924 hsa-miR-29b-1* hsa-miR-105 hsa-miR-374a* hsa-miR-223 hsa-miR-200c
    SwitchGear 3'UTR luciferase reporter plasmid: COPS8 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COPS8 (see all 7)
    OriGene shRNA RFP: COPS8
    OriGene siRNA: COPS8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COPS8

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for COPS8

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COPS8 (see all 4)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): COPS8 (NM_006710)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COPS8 

    Cell Line
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    Search LifeMap BioReagents cell lines for COPS8

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPS8

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----


    COPS8 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for COPS8:
     Increased cell death in HCT116  Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-out Cops8tm1.1Nwe for COPS8
         6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cops8):
     cellular  embryogenesis  growth/size  hematopoietic system  immune system 
     mortality/aging 

    COPS8 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for COPS8 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for COPS8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/55 Interacting proteins for COPS8 (Q996272, 3 ENSP000003463404) via UniProtKB, MINT, STRING, and/or I2D (see all 55)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GFERP557892, 3, ENSP000002481144MINT-50638 MINT-50731 MINT-50628 MINT-50635 MINT-50627 I2D: score=1 STRING: ENSP00000248114
    COPS3Q9UNS22, 3, ENSP000002687174MINT-7230300 I2D: score=6 STRING: ENSP00000268717
    COPS5Q929052, 3, ENSP000003505124MINT-7230300 I2D: score=5 STRING: ENSP00000350512
    COPS6Q7L5N12, 3, ENSP000003041024MINT-7230300 I2D: score=5 STRING: ENSP00000304102
    COPS4Q9BT782, 3, ENSP000002643894MINT-7230300 I2D: score=4 STRING: ENSP00000264389
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010388cullin deneddylation IDA19141280


    COPS8 for ontologies           About GeneDecksing



    Drugs & Compounds
    for COPS8 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for COPS8
    Search CenterWatch for drugs/clinical trials and news about COPS8 / CSN8 

    Transcripts
    for COPS8 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for COPS8 gene (2 alternative transcripts): 
    NM_006710.4  NM_198189.2  

    Unigene Cluster for COPS8:

    COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)
    Hs.531713  [show with all ESTs]
    Unigene Representative Sequence: NM_198189
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354371(uc010fys.1 uc002vwg.3 uc002vwh.3) ENST00000392008
    ENST00000409334 ENST00000470452 ENST00000419015 ENST00000409629 ENST00000447464
    ENST00000465362

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): COPS8
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COPS8
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate COPS8 (see all 12):
    hsa-miR-429 hsa-miR-7-2* hsa-miR-3924 hsa-miR-29b-1* hsa-miR-105 hsa-miR-374a* hsa-miR-223 hsa-miR-200c
    SwitchGear 3'UTR luciferase reporter plasmid: COPS8 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COPS8 (see all 7)
    OriGene shRNA RFP: COPS8
    OriGene siRNA: COPS8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COPS8
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COPS8 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): COPS8 (NM_006710)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COPS8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COPS8 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat COPS8
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COPS8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COPS8

    Additional cDNA sequence: 

    AK289891.1 AK294078.1 AK308962.1 AK313437.1 BC003090.1 BC036499.1 BC067774.1 BC080617.1 
    CR456994.1 U51205.1 

    18 DOTS entries:

    DT.95357757  DT.453359  DT.101976759  DT.100818621  DT.120874659  DT.91959708  DT.425551  DT.100818626 
    DT.121005431  DT.100697697  DT.419907  DT.91950080  DT.121005451  DT.121005465  DT.70104821  DT.92447656 
    DT.95254541  DT.100637345 

    24/508 AceView cDNA sequences (see all 508):

    AA044136 CR619073 BM849190 BE328029 F10095 AA195638 BM800641 BQ425355 
    CR624288 F04126 AI366081 CR607837 AI421726 F06866 CR613293 BP341819 
    AI983492 BQ189508 AA165506 BQ026823 AA878067 BI833901 CR595044 Z45234 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for COPS8 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11
    SP1:                                -           -                                   -                                             
    SP2:                                -           -                 -     -     -     -                                             
    SP3:                                            -                                   -                                             
    SP4:                                -                                               -                                             
    SP5:                                -           -                                                                                 


    ECgene alternative splicing isoforms for COPS8

    Expression
    for COPS8 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    COPS8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATACACTTTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See COPS8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for COPS8

    SOURCE GeneReport for Unigene cluster: Hs.531713
        SABiosciences Custom PCR Arrays for COPS8
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPS8

    Orthologs
    for COPS8 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for COPS8 gene from 8/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cops81 , 5 COP9 (constitutive photomorphogenic) homolog, subunit more1, 5 89.95(n)1
    95.22(a)1    		   1 (45.53 cM)5
    1086791  NM_133805.31  NP_598566.31 
     906034255 
    chicken
    (Gallus gallus)    		 Aves COPS81 COP9 constitutive photomorphogenic homolog subunit more 82.45(n)
    88.89(a)    		   424020  NM_001048007.1  NP_001041472.1 
    lizard
    (Anolis carolinensis)    		 Reptilia COPS86
    		 --
    		 84(a)
    		 1 ↔ 1
    		 1(120295512-120321722)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.225662 Xenopus laevis transcribed sequence with moderate similarity more 79.31(n)    BJ073548.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc563192 similar to COP9 homolog 74.67(n)   393198  BC046071.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CSN81 COP9 complex homolog subunit 8 43.13(n)
    29.38(a)    		   49077  NM_164809.4  NP_723378.2 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons COP91 COP9 signalosome complex subunit 8 47.13(n)
    33.87(a)    		   827049  NM_117488.3  NP_193147.1 
    rice
    (Oryza sativa)    		 Liliopsida Os04g04289001 hypothetical protein 44.87(n)
    34.62(a)    		   4335854  NM_001059340.1  NP_001052805.1 


    ENSEMBL Gene Tree for COPS8 (if available)
    TreeFam Gene Tree for COPS8 (if available) 

    Paralogs
    for COPS8 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for COPS8 gene

    COPS8 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for COPS8
    PGOHUM00000242812 PGOHUM00000250284 PGOHUM00000241426


    Genomic Variants
    for COPS8 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/302 NCBI SNPs in COPS8 are shown (see all 302)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1815805811,2
    		--237992138(+) GCAGCC/TGTGGA 2 -- us2k10--------
    rs1434313491,2
    		--237992557(+) CACAAA/GGTACT 2 -- us2k10--------
    rs785843441,2
    		C,F,--237992600(+) CTGACA/GCCCCA 2 -- us2k11Minor allele frequency- G:0.02NA 120
    rs75776301,2
    		C,F,A,H,--237992613(+) AGGCCA/GCACTT 2 -- us2k122Minor allele frequency- G:0.44NS EA WA NA CSA 2343
    rs1838130661,2
    		--237992739(+) GGATAC/TATATA 2 -- us2k10--------
    rs1449088221,2
    		--237992757(+) ATATAG/TATATA 2 -- us2k10--------
    rs561058981,2
    		C,--237992759(+) ATATAG/TATAGA 2 -- us2k10--------
    rs126179181,2
    		C,H,--237992761(+) ATATAG/TAGAGA 2 -- us2k15Minor allele frequency- T:0.08NA WA CSA 12
    rs1512239791,2
    		--237992763(+) ATATAG/TAGAGA 2 -- us2k10--------
    rs1400565081,2
    		--237992765(+) ATAGAG/TAGAGA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for COPS8 (237993955 - 238009109 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for COPS8: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for COPS8 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    COPS8 for disorders           About GeneDecksing

    OMIM gene information: 601349    OMIM disorders: --

    8 diseases for COPS8:    About MalaCards
    microphthalmia syndromic 8    smith-magenis syndrome    microphthalmia    myeloid leukemia
    leukemia    hypoxia    adenomatous polyposis coli    polyposis


    Export disorders for COPS8 gene to outside databases

    Publications
    for COPS8 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for COPS8 gene, integrated from 9 sources (see all 72):
    (articles sorted by number of sources associating them with COPS8)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. (PubMed id 12732143)1, 2, 3 Groisman R.... Nakatani Y. (2003)
    2. The novel components of the Arabidopsis light signaling pathway may define a group of general developmental regulators shared by both animal and plant kingdoms. (PubMed id 7634324)1, 2, 3 Chamovitz D.A. and Deng X.-W. (1995)
    3. A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. (PubMed id 9535219)1, 2, 9 Seeger M....Dubiel W. (1998)
    4. Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. (PubMed id 18850735)1, 2 Fang L.... Huang L. (2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome. (PubMed id 12628923)1, 2 Uhle S....Dubiel W. (2003)
    7. COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system. (PubMed id 11285227)1, 2 Bech-Otschir D.... Dubiel W. (2001)
    8. Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. (PubMed id 11337588)1, 2 Lyapina S.... Deshaies R.J. (2001)
    9. Electron microscopy and subunit-subunit interaction studies reveal a first architecture of COP9 signalosome. (PubMed id 10903862)1, 9 Kapelari B....Dubiel W. (2000)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    External Searches for COPS8 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing COPS8 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10920 HGNC: 24335 AceView: COPS8 Ensembl:ENSG00000198612 euGenes: HUgn10920
    ECgene: COPS8 H-InvDB: COPS8

    Other Databases showing COPS8 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing COPS8 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for COPS8 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for COPS8 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for COPS8 gene:
    Search GeneIP for patents involving COPS8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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