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Aliases for COPS8 Gene

Aliases for COPS8 Gene

  • COP9 Signalosome Subunit 8 2 3 5
  • JAB1-Containing Signalosome Subunit 8 3 4
  • Signalosome Subunit 8 3 4
  • COP9 Homolog 3 4
  • HCOP9 3 4
  • CSN8 3 4
  • SGN8 3 4
  • COP9 Constitutive Photomorphogenic Homolog Subunit 8 (Arabidopsis) 2
  • COP9 Constitutive Photomorphogenic Homolog Subunit 8 3
  • COP9 Signalosome Complex Subunit 8 3
  • COP9 3

External Ids for COPS8 Gene

Previous GeneCards Identifiers for COPS8 Gene

  • GC02P238280
  • GC02P237776
  • GC02P237658
  • GC02P237993
  • GC02P229786

Summaries for COPS8 Gene

Entrez Gene Summary for COPS8 Gene

  • The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

GeneCards Summary for COPS8 Gene

COPS8 (COP9 Signalosome Subunit 8) is a Protein Coding gene. Diseases associated with COPS8 include Familial Hypertension. Among its related pathways are Vesicle-mediated transport and Transcription-Coupled Nucleotide Excision Repair (TC-NER).

UniProtKB/Swiss-Prot for COPS8 Gene

  • Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Gene Wiki entry for COPS8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COPS8 Gene

Genomics for COPS8 Gene

Regulatory Elements for COPS8 Gene

Enhancers for COPS8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F237154 1.6 FANTOM5 Ensembl ENCODE 7.4 +71.0 71030 4.2 PKNOX1 SIN3A ARID4B DMAP1 THRB RAD21 ZNF48 YY1 ZNF143 FOS COPS8 COL6A3 MLPH LOC105373952 LOC105373953
GH02F237126 1.2 Ensembl ENCODE 7.5 +42.5 42453 2.7 INSM2 KLF17 GLI4 ZNF2 ZEB1 ZNF366 ZNF391 FOS EGR2 SP3 MLPH COPS8 ENSG00000224844 LOC105373952
GH02F237169 1.5 FANTOM5 Ensembl ENCODE 5.9 +86.3 86251 3.8 ATF1 MLX ZFP64 ARID4B DMAP1 YBX1 ZNF48 YY1 FOS SP5 ENSG00000222022 LOC105373953 COPS8 COL6A3 LOC105373952
GH02F237177 1.3 FANTOM5 Ensembl ENCODE 6.8 +96.1 96088 8.3 JUN RAD21 ZNF121 GATA3 POLR2A SMC3 PRDM10 FOS TCF7L2 PAF1 LOC105373953 COL6A3 ENSG00000222022 COPS8 LOC105373952
GH02F237195 1.6 FANTOM5 Ensembl ENCODE 4.8 +114.2 114237 8.1 HDGF ATF1 MLX WRNIP1 ARID4B DMAP1 ZNF48 YY1 ZNF143 FOS COL6A3 ENSG00000222022 MLPH COPS8 LOC105373953 LOC105373952
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around COPS8 on UCSC Golden Path with GeneCards custom track

Promoters for COPS8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000019662 688 2401 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1

Genomic Location for COPS8 Gene

Chromosome:
2
Start:
237,085,312 bp from pter
End:
237,100,466 bp from pter
Size:
15,155 bases
Orientation:
Plus strand

Genomic View for COPS8 Gene

Genes around COPS8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COPS8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COPS8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COPS8 Gene

Proteins for COPS8 Gene

  • Protein details for COPS8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99627-CSN8_HUMAN
    Recommended name:
    COP9 signalosome complex subunit 8
    Protein Accession:
    Q99627
    Secondary Accessions:
    • A8K1H6
    • Q53QS9

    Protein attributes for COPS8 Gene

    Size:
    209 amino acids
    Molecular mass:
    23226 Da
    Quaternary structure:
    • Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 isoform 1 (PubMed:11337588, PubMed:18850735, PubMed:26456823). In the complex, it probably interacts directly with COPS3, COPS4 and COPS7 (COPS7A or COPS7B) (PubMed:18850735).

    Three dimensional structures from OCA and Proteopedia for COPS8 Gene

    Alternative splice isoforms for COPS8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COPS8 Gene

Post-translational modifications for COPS8 Gene

  • Ubiquitination at Lys 15, Lys 65, and Lys 178
  • Modification sites at PhosphoSitePlus

Other Protein References for COPS8 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for COPS8

No data available for DME Specific Peptides for COPS8 Gene

Domains & Families for COPS8 Gene

Gene Families for COPS8 Gene

Protein Domains for COPS8 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q99627

UniProtKB/Swiss-Prot:

CSN8_HUMAN :
  • Contains 1 PCI domain.
  • Belongs to the CSN8 family.
Domain:
  • Contains 1 PCI domain.
Family:
  • Belongs to the CSN8 family.
genes like me logo Genes that share domains with COPS8: view

Function for COPS8 Gene

Molecular function for COPS8 Gene

UniProtKB/Swiss-Prot Function:
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Gene Ontology (GO) - Molecular Function for COPS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with COPS8: view
genes like me logo Genes that share phenotypes with COPS8: view

Animal Models for COPS8 Gene

MGI Knock Outs for COPS8:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for COPS8 Gene

Localization for COPS8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COPS8 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for COPS8 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
cytoskeleton 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for COPS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 8689678
GO:0005654 nucleoplasm IDA,TAS --
GO:0005737 cytoplasm IDA --
GO:0008180 COP9 signalosome IEA,IDA 9535219
GO:0048471 perinuclear region of cytoplasm IDA 9535219
genes like me logo Genes that share ontologies with COPS8: view

Pathways & Interactions for COPS8 Gene

genes like me logo Genes that share pathways with COPS8: view

Gene Ontology (GO) - Biological Process for COPS8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000715 nucleotide-excision repair, DNA damage recognition TAS --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0007250 activation of NF-kappaB-inducing kinase activity IMP 22992343
GO:0008285 negative regulation of cell proliferation IMP 23689509
GO:0010387 COP9 signalosome assembly IEA --
genes like me logo Genes that share ontologies with COPS8: view

No data available for SIGNOR curated interactions for COPS8 Gene

Transcripts for COPS8 Gene

Unigene Clusters for COPS8 Gene

COP9 signalosome subunit 8:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COPS8 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11
SP1: - - -
SP2: - - - - - -
SP3: - -
SP4: - -
SP5: - -
SP6: - - - - - -
SP7: - - - - - -

Relevant External Links for COPS8 Gene

GeneLoc Exon Structure for
COPS8
ECgene alternative splicing isoforms for
COPS8

Expression for COPS8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for COPS8 Gene

Protein differential expression in normal tissues from HIPED for COPS8 Gene

This gene is overexpressed in Bone marrow stromal cell (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for COPS8 Gene



Protein tissue co-expression partners for COPS8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of COPS8 Gene:

COPS8

SOURCE GeneReport for Unigene cluster for COPS8 Gene:

Hs.531713
genes like me logo Genes that share expression patterns with COPS8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for COPS8 Gene

Orthologs for COPS8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for COPS8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COPS8 34
  • 99.68 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 98 (a)
OneToMany
COPS8 34
  • 91.39 (n)
-- 35
  • 86 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia COPS8 35
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cops8 34 16 35
  • 89.95 (n)
cow
(Bos Taurus)
Mammalia COPS8 34 35
  • 89 (n)
rat
(Rattus norvegicus)
Mammalia Cops8 34
  • 88.52 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia COPS8 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves COPS8 34 35
  • 82.45 (n)
lizard
(Anolis carolinensis)
Reptilia COPS8 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cops8 34
  • 75.13 (n)
MGC76051 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.22566 34
zebrafish
(Danio rerio)
Actinopterygii cops8 34 35
  • 68.24 (n)
zgc56319 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008857 34
  • 48.13 (n)
fruit fly
(Drosophila melanogaster)
Insecta CSN8 34 35
  • 42.94 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons COP9 34
  • 47.31 (n)
rice
(Oryza sativa)
Liliopsida Os04g0428900 34
  • 45.62 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6909 35
  • 34 (a)
OneToOne
Species where no ortholog for COPS8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COPS8 Gene

ENSEMBL:
Gene Tree for COPS8 (if available)
TreeFam:
Gene Tree for COPS8 (if available)

Paralogs for COPS8 Gene

Pseudogenes.org Pseudogenes for COPS8 Gene

genes like me logo Genes that share paralogs with COPS8: view

No data available for Paralogs for COPS8 Gene

Variants for COPS8 Gene

Sequence variations from dbSNP and Humsavar for COPS8 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10188872 -- 237,084,516(+) atcac(C/T)CATAT nc-transcript-variant, upstream-variant-2KB
rs10203474 -- 237,098,849(+) GAATG(C/T)ATTTT downstream-variant-500B
rs111263661 -- 237,086,644(+) TCACT(A/G)ATAGA intron-variant, upstream-variant-2KB
rs111267398 -- 237,089,836(+) ATACC(C/T)TCTAA intron-variant
rs111475167 -- 237,087,618(+) TTCAC(A/G)TGGAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for COPS8 Gene

Variant ID Type Subtype PubMed ID
nsv1000252 CNV loss 25217958

Variation tolerance for COPS8 Gene

Residual Variation Intolerance Score: 52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.65; 13.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COPS8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
COPS8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COPS8 Gene

Disorders for COPS8 Gene

MalaCards: The human disease database

(1) MalaCards diseases for COPS8 Gene - From: GeneCards

Disorder Aliases PubMed IDs
familial hypertension
  • genetic hypertension
- elite association - COSMIC cancer census association via MalaCards
Search COPS8 in MalaCards View complete list of genes associated with diseases

Relevant External Links for COPS8

Genetic Association Database (GAD)
COPS8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COPS8
genes like me logo Genes that share disorders with COPS8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for COPS8 Gene

Publications for COPS8 Gene

  1. The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. (PMID: 12732143) Groisman R. … Nakatani Y. (Cell 2003) 2 3 4 64
  2. A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. (PMID: 9535219) Seeger M. … Dubiel W. (FASEB J. 1998) 3 4 22 64
  3. The novel components of the Arabidopsis light signaling pathway may define a group of general developmental regulators shared by both animal and plant kingdoms. (PMID: 7634324) Chamovitz D.A. … Deng X.-W. (Cell 1995) 2 3 4 64
  4. CSNAP Is a Stoichiometric Subunit of the COP9 Signalosome. (PMID: 26456823) Rozen S. … Sharon M. (Cell Rep 2015) 3 4 64
  5. Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. (PMID: 18850735) Fang L. … Huang L. (J. Proteome Res. 2008) 3 4 64

Products for COPS8 Gene

Sources for COPS8 Gene

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