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COPS8 Gene

protein-coding   GIFtS: 52
GCID: GC02P237993

COP9 Signalosome Subunit 8

(Previous name: COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
COP9 Signalosome Subunit 81 2     JAB1-Containing Signalosome Subunit 82 3
Signalosome Subunit 82 3     COP9 Constitutive Photomorphogenic Homolog Subunit 8 (Arabidopsis)1
CSN82 3     COP92
SGN82 3     COP9 Constitutive Photomorphogenic Homolog Subunit 82
COP9 Homolog2 3     COP9 Signalosome Complex Subunit 82
hCOP92 3     MMMEP5

External Ids:    HGNC: 243351   Entrez Gene: 109202   Ensembl: ENSG000001986127   OMIM: 6013495   UniProtKB: Q996273   

Export aliases for COPS8 gene to outside databases

Previous GC identifers: GC02P238280 GC02P237776 GC02P237658 GC02P229786


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for COPS8 Gene:
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein
complex that functions as an important regulator in multiple signaling pathways. The structure and function of
COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been
shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases.
Alternatively spliced transcript variants encoding distinct isoforms have been observed. (provided by RefSeq, Jul
2008)

GeneCards Summary for COPS8 Gene:
COPS8 (COP9 signalosome subunit 8) is a protein-coding gene.

UniProtKB/Swiss-Prot: CSN8_HUMAN, Q99627
Function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and
developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by
mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl
ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation
of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD
kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system,
respectively

Gene Wiki entry for COPS8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the COPS8 gene promoter:
         USF1   p53   USF-1   HNF-3beta   NF-kappaB1   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): COPS8 promoter sequence
   Search Chromatin IP Primers for COPS8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COPS8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.3   Ensembl cytogenetic band:  2q37.3   HGNC cytogenetic band: 2q37.3

COPS8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COPS8 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P237993:  view genomic region     (about GC identifiers)

Start:
237,993,955 bp from pter      End:
238,009,109 bp from pter
Size:
15,155 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CSN8_HUMAN, Q99627 (See protein sequence)
Recommended Name: COP9 signalosome complex subunit 8  
Size: 209 amino acids; 23226 Da
Subunit: Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or
COPS7B) and COPS8. In the complex, it probably interacts directly with COPS3, COPS4 and COPS7 (COPS7A or COPS7B)
Secondary accessions: A8K1H6 Q53QS9
Alternative splicing: 2 isoforms:  Q99627-1   Q99627-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for COPS8: NX_Q99627

Explore proteomics data for COPS8 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys15, Lys65, Lys178
  • Modification sites at PhosphoSitePlus

  • See COPS8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_006701.1  NP_937832.1  

    ENSEMBL proteins: 
     ENSP00000346340   ENSP00000375865   ENSP00000387212   ENSP00000388655   ENSP00000386838  
     ENSP00000413696  

    COPS8 Human Recombinant Protein Products:

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    Novus Biologicals COPS8 Proteins
    Novus Biologicals COPS8 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for COPS8
    Cloud-Clone Corp. Proteins for COPS8

     
    Search eBioscience for Proteins for COPS8 

     
    antibodies-online proteins for COPS8 (9 products) 

     
    antibodies-online peptides for COPS8

    COPS8 Antibody Products:

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    Abcam antibodies for COPS8 (A8K1H6, Q99627)
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    antibodies-online antibodies for COPS8 (42 products) 

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    Cloud-Clone Corp. ELISAs for COPS8
    Cloud-Clone Corp. CLIAs for COPS8
    Search eBioscience for ELISAs for COPS8 
    antibodies-online kits for COPS8 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q99627

    UniProtKB/Swiss-Prot: CSN8_HUMAN, Q99627
    Similarity: Belongs to the CSN8 family
    Similarity: Contains 1 PCI domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CSN8_HUMAN, Q99627
    Function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and
    developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by
    mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl
    ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation
    of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD
    kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system,
    respectively

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with COPS8           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for COPS8:
     Increased cell death in HCT116  Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cops8):
     cellular  embryogenesis  growth/size/body  hematopoietic system  immune system 
     mortality/aging 

    Find genes that share phenotypes with COPS8           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cops8tm1.1Nwe for COPS8

       genOway: Develop your customized and physiologically relevant rodent model for COPS8

    miRNA
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    miRTarBase miRNAs that target COPS8:
    hsa-let-7f-5p (MIRT032086), hsa-let-7c-5p (MIRT032190), hsa-let-7e-3p (MIRT032094), hsa-let-7i-5p (MIRT024114)

    Block miRNA regulation of human, mouse, rat COPS8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate COPS8 (see all 12):
    hsa-miR-429 hsa-miR-7-2* hsa-miR-3924 hsa-miR-29b-1* hsa-miR-105 hsa-miR-374a* hsa-miR-223 hsa-miR-200c
    SwitchGear 3'UTR luciferase reporter plasmidCOPS8 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat COPS8

    Gene Editing
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    Sino Biological Human cDNA Clone for COPS8
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COPS8

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPS8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CSN8_HUMAN, Q99627: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton3
    cytosol3
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0008180COP9 signalosome IDA18850735
    GO:0048471perinuclear region of cytoplasm IDA9535219

    Find genes that share ontologies with COPS8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for COPS8
    Interactions:

        GeneGlobe Interaction Network for COPS8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for COPS8 (Q996272, 3 ENSP000003463404) via UniProtKB, MINT, STRING, and/or I2D (see all 60)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GFERP557892, 3, ENSP000002481144MINT-50638 MINT-50731 MINT-50628 MINT-50635 MINT-50627 I2D: score=1 STRING: ENSP00000248114
    COPS3Q9UNS22, 3, ENSP000002687174MINT-7230300 I2D: score=6 STRING: ENSP00000268717
    COPS5Q929052, 3, ENSP000003505124MINT-7230300 I2D: score=5 STRING: ENSP00000350512
    COPS6Q7L5N12, 3, ENSP000003041024MINT-7230300 I2D: score=5 STRING: ENSP00000304102
    COPS4Q9BT782, 3, ENSP000002643894MINT-7230300 I2D: score=4 STRING: ENSP00000264389
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007250activation of NF-kappaB-inducing kinase activity IMP--
    GO:0008285negative regulation of cell proliferation IMP--
    GO:0010388cullin deneddylation IDA19141280

    Find genes that share ontologies with COPS8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for COPS8 (CSN8)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for COPS8 gene (2 alternative transcripts): 
    NM_006710.4  NM_198189.2  

    Unigene Cluster for COPS8:

    COP9 signalosome subunit 8
    Hs.531713  [show with all ESTs]
    Unigene Representative Sequence: NM_198189
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354371(uc010fys.1 uc002vwg.3 uc002vwh.3) ENST00000392008
    ENST00000409334 ENST00000470452 ENST00000419015 ENST00000409629 ENST00000447464
    ENST00000465362
    miRNA
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    Block miRNA regulation of human, mouse, rat COPS8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate COPS8 (see all 12):
    hsa-miR-429 hsa-miR-7-2* hsa-miR-3924 hsa-miR-29b-1* hsa-miR-105 hsa-miR-374a* hsa-miR-223 hsa-miR-200c
    SwitchGear 3'UTR luciferase reporter plasmidCOPS8 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for COPS8
    Predesigned siRNA for gene silencing in human, mouse, rat COPS8
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    GenScript: all cDNA clones in your preferred vector (see all 2): COPS8 (NM_006710)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COPS8
    Primer
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    OriGene qPCR primer pairs and template standards for COPS8
    OriGene qSTAR qPCR primer pairs in human, mouse for COPS8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat COPS8
      QuantiTect SYBR Green Assays in human, mouse, rat COPS8
      QuantiFast Probe-based Assays in human, mouse, rat COPS8

    Additional mRNA sequence: 

    AK289891.1 AK294078.1 AK308962.1 AK313437.1 BC003090.1 BC036499.1 BC067774.1 BC080617.1 
    CR456994.1 U51205.1 

    18 DOTS entries:

    DT.95357757  DT.453359  DT.101976759  DT.100818621  DT.120874659  DT.91959708  DT.425551  DT.100818626 
    DT.121005431  DT.100697697  DT.419907  DT.91950080  DT.121005451  DT.121005465  DT.70104821  DT.92447656 
    DT.95254541  DT.100637345 

    Selected AceView cDNA sequences (see all 508):

    F04126 F06866 AI421726 CR613293 BP341819 AI983492 AA878067 BQ189508 
    AA165506 BI833901 BQ026823 CN484900 NM_198189 AA723173 CR595044 Z45234 
    AA515513 F03158 BQ228308 CR595867 F03133 AL551778 BQ001569 BE348876 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for COPS8 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11
    SP1:                                -           -                                   -                                             
    SP2:                                -           -                 -     -     -     -                                             
    SP3:                                            -                                   -                                             
    SP4:                                -                                               -                                             
    SP5:                                -           -                                                                                 


    ECgene alternative splicing isoforms for COPS8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    COPS8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATACACTTTG
    COPS8 Expression
    About this image

    COPS8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    COPS8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.531713
        Custom PCR Arrays for COPS8
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPS8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for COPS8 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cops81 , 5 COP9 (constitutive photomorphogenic) homolog, subunit more1, 5 89.95(n)1
    95.22(a)1
      1 (45.53 cM)5
    1086791  NM_133805.31  NP_598566.31 
     906034255 
    chicken
    (Gallus gallus)
    Aves COPS81 COP9 constitutive photomorphogenic homolog subunit more 82.45(n)
    88.89(a)
      424020  NM_001048007.1  NP_001041472.1 
    lizard
    (Anolis carolinensis)
    Reptilia COPS86
    COP9 signalosome subunit 8
    85(a)
    1 ↔ 1
    1(120295512-120321722)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.225662 Xenopus laevis transcribed sequence with moderate similarity more 79.31(n)    BJ073548.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc563192 similar to COP9 homolog 74.67(n)   393198  BC046071.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CSN81 COP9 complex homolog subunit 8 42.94(n)
    29.94(a)
      49077  NM_164809.4  NP_723378.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons COP91 COP9 47.31(n)
    34.41(a)
      827049  NM_117488.3  NP_193147.1 
    rice
    (Oryza sativa)
    Liliopsida Os04g04289001 Os04g0428900 45.62(n)
    37.99(a)
      4335854  NM_001059340.1  NP_001052805.1 


    ENSEMBL Gene Tree for COPS8 (if available)
    TreeFam Gene Tree for COPS8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for COPS8 gene

    Find genes that share paralogs with COPS8           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for COPS8
    PGOHUM00000242812 PGOHUM00000250284 PGOHUM00000241426


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for COPS8 (see all 380)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1815805811,2
    --237992138(+) GCAGCC/TGTGGA 2 -- us2k10--------
    rs614371501,2
    C--237992256(+) TTTTT-/TCTTTA 2 -- us2k10--------
    rs1434313491,2
    --237992557(+) CACAAA/GGTACT 2 -- us2k10--------
    rs785843441,2
    C,F--237992600(+) CTGACA/GCCCCA 2 -- us2k11Minor allele frequency- G:0.02NA 120
    rs75776301,2
    C,F,A,H--237992613(+) aggccA/Gcactt 2 -- us2k122Minor allele frequency- G:0.44NS EA WA NA CSA 2343
    rs1838130661,2
    --237992739(+) GGATAC/TATATA 2 -- us2k10--------
    rs1449088221,2
    --237992757(+) ATATAG/TATATA 2 -- us2k10--------
    rs561058981,2
    C--237992759(+) ATATAG/TATAGA 2 -- us2k10--------
    rs126179181,2
    C,H--237992761(+) atataG/Tagaga 2 -- us2k15Minor allele frequency- T:0.08NA WA CSA 12
    rs1512239791,2
    --237992763(+) ATATAG/TAGAGA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for COPS8 (237993955 - 238009109 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for COPS8: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing COPS8
    DNA2.0 Custom Variant and Variant Library Synthesis for COPS8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601349    OMIM disorders: --


    Find genes that share disorders with COPS8           About GenesLikeMe

    Genetic Association Database (GAD): COPS8

    Export disorders for COPS8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for COPS8 gene, integrated from 10 sources (see all 80):
    (articles sorted by number of sources associating them with COPS8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. (PubMed id 12732143)1, 2, 3 Groisman R.... Nakatani Y. (Cell 2003)
    2. The novel components of the Arabidopsis light signaling pathway may define a group of general developmental regulators shared by both animal and plant kingdoms. (PubMed id 7634324)1, 2, 3 Chamovitz D.A. and Deng X.-W. (Cell 1995)
    3. A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. (PubMed id 9535219)1, 2, 9 Seeger M.... Dubiel W. (FASEB J. 1998)
    4. Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. (PubMed id 18850735)1, 2 Fang L.... Huang L. (J. Proteome Res. 2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome. (PubMed id 12628923)1, 2 Uhle S....Dubiel W. (EMBO J. 2003)
    7. COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system. (PubMed id 11285227)1, 2 Bech-Otschir D.... Dubiel W. (EMBO J. 2001)
    8. Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. (PubMed id 11337588)1, 2 Lyapina S.... Deshaies R.J. (Science 2001)
    9. Electron microscopy and subunit-subunit interaction studies reveal a first architecture of COP9 signalosome. (PubMed id 10903862)1, 9 Kapelari B....Dubiel W. (J. Mol. Biol. 2000)
    10. The novel ubiquitin ligase complex, SCF(Fbxw4), interacts with the COP9 signalosome in an F-box dependent manner, is mutated, lost and under-expressed in human cancers. (PubMed id 23658844)1 Lockwood W.W....Beverly L.J. (PLoS ONE 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10920 HGNC: 24335 AceView: COPS8 Ensembl:ENSG00000198612 euGenes: HUgn10920
    ECgene: COPS8 H-InvDB: COPS8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for COPS8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for COPS8 gene:
    Search GeneIP for patents involving COPS8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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