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Aliases for COPS7B Gene

Aliases for COPS7B Gene

  • COP9 Signalosome Subunit 7B 2 3
  • JAB1-Containing Signalosome Subunit 7b 3 4
  • Signalosome Subunit 7b 3 4
  • CSN7B 3 4
  • SGN7b 3 4
  • COP9 (Constitutive Photomorphogenic, Arabidopsis, Homolog) Subunit 7B 2
  • COP9 Constitutive Photomorphogenic Homolog Subunit 7B (Arabidopsis) 2
  • COP9 Constitutive Photomorphogenic Homolog Subunit 7B 3

External Ids for COPS7B Gene

Previous GeneCards Identifiers for COPS7B Gene

  • GC02P230710
  • GC02P231382
  • GC02P232610
  • GC02P232853
  • GC02P232476
  • GC02P232359
  • GC02P232646
  • GC02P224495

Summaries for COPS7B Gene

GeneCards Summary for COPS7B Gene

COPS7B (COP9 Signalosome Subunit 7B) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and Transcription-Coupled Nucleotide Excision Repair (TC-NER). An important paralog of this gene is COPS7A.

UniProtKB/Swiss-Prot for COPS7B Gene

  • Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Gene Wiki entry for COPS7B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COPS7B Gene

Genomics for COPS7B Gene

Regulatory Elements for COPS7B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for COPS7B Gene

Chromosome:
2
Start:
231,781,671 bp from pter
End:
231,809,254 bp from pter
Size:
27,584 bases
Orientation:
Plus strand

Genomic View for COPS7B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COPS7B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COPS7B Gene

Proteins for COPS7B Gene

  • Protein details for COPS7B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H9Q2-CSN7B_HUMAN
    Recommended name:
    COP9 signalosome complex subunit 7b
    Protein Accession:
    Q9H9Q2
    Secondary Accessions:
    • Q53S22
    • Q5BJG3
    • Q9H7V6

    Protein attributes for COPS7B Gene

    Size:
    264 amino acids
    Molecular mass:
    29622 Da
    Quaternary structure:
    • Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS1, COPS2, COPS4, COPS5, COPS6 and COPS8.

    Alternative splice isoforms for COPS7B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COPS7B Gene

Proteomics data for COPS7B Gene at MOPED

Post-translational modifications for COPS7B Gene

  • Ubiquitination at Lys 118, Lys 217, and Lys 221
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for COPS7B Gene

Domains & Families for COPS7B Gene

Gene Families for COPS7B Gene

Protein Domains for COPS7B Gene

Suggested Antigen Peptide Sequences for COPS7B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H9Q2

UniProtKB/Swiss-Prot:

CSN7B_HUMAN :
  • Contains 1 PCI domain.
  • Belongs to the CSN7/EIF3M family. CSN7 subfamily.
Domain:
  • Contains 1 PCI domain.
Family:
  • Belongs to the CSN7/EIF3M family. CSN7 subfamily.
genes like me logo Genes that share domains with COPS7B: view

Function for COPS7B Gene

Molecular function for COPS7B Gene

UniProtKB/Swiss-Prot Function:
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Gene Ontology (GO) - Molecular Function for COPS7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with COPS7B: view

Phenotypes for COPS7B Gene

GenomeRNAi human phenotypes for COPS7B:
genes like me logo Genes that share phenotypes with COPS7B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COPS7B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for COPS7B Gene

Localization for COPS7B Gene

Subcellular locations from UniProtKB/Swiss-Prot for COPS7B Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COPS7B Gene COMPARTMENTS Subcellular localization image for COPS7B gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for COPS7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0008180 COP9 signalosome IDA 18850735
genes like me logo Genes that share ontologies with COPS7B: view

Pathways & Interactions for COPS7B Gene

genes like me logo Genes that share pathways with COPS7B: view

Gene Ontology (GO) - Biological Process for COPS7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000715 nucleotide-excision repair, DNA damage recognition TAS --
GO:0006281 DNA repair TAS --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0006289 nucleotide-excision repair TAS --
GO:0010388 cullin deneddylation IDA 19141280
genes like me logo Genes that share ontologies with COPS7B: view

No data available for SIGNOR curated interactions for COPS7B Gene

Drugs & Compounds for COPS7B Gene

No Compound Related Data Available

Transcripts for COPS7B Gene

Unigene Clusters for COPS7B Gene

COP9 signalosome subunit 7B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COPS7B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COPS7B Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - -
SP7: - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - - - - - - - - - -
SP10: - -
SP11: - -
SP12: - -

Relevant External Links for COPS7B Gene

GeneLoc Exon Structure for
COPS7B
ECgene alternative splicing isoforms for
COPS7B

Expression for COPS7B Gene

mRNA expression in normal human tissues for COPS7B Gene

Protein differential expression in normal tissues from HIPED for COPS7B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for COPS7B Gene



SOURCE GeneReport for Unigene cluster for COPS7B Gene Hs.335061

genes like me logo Genes that share expression patterns with COPS7B: view

Protein tissue co-expression partners for COPS7B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for COPS7B Gene

Orthologs for COPS7B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for COPS7B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia COPS7B 35
  • 92.93 (n)
  • 99.62 (a)
COPS7B 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COPS7B 35
  • 94.57 (n)
  • 99.62 (a)
COPS7B 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cops7b 35
  • 92.68 (n)
  • 98.11 (a)
Cops7b 16
Cops7b 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia COPS7B 35
  • 99.62 (n)
  • 100 (a)
COPS7B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cops7b 35
  • 92.93 (n)
  • 97.73 (a)
oppossum
(Monodelphis domestica)
Mammalia COPS7B 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COPS7B 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves COPS7B 35
  • 81.19 (n)
  • 92.05 (a)
COPS7B 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COPS7B 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cops7b 35
  • 76.77 (n)
  • 86.36 (a)
Str.8177 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.17235 35
zebrafish
(Danio rerio)
Actinopterygii wufa19h06 35
fruit fly
(Drosophila melanogaster)
Insecta CSN7b 37
  • 44 (a)
CSN7 35
  • 54.45 (n)
  • 47.41 (a)
CSN7 36
  • 40 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012398 35
  • 59.71 (n)
  • 53.48 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons FUS5 35
  • 46.58 (n)
  • 37.5 (a)
rice
(Oryza sativa)
Liliopsida Os07g0490800 35
  • 47.77 (n)
  • 36.08 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08342 35
  • 47.21 (n)
  • 37.1 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9499 36
  • 40 (a)
OneToMany
Species with no ortholog for COPS7B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COPS7B Gene

ENSEMBL:
Gene Tree for COPS7B (if available)
TreeFam:
Gene Tree for COPS7B (if available)

Paralogs for COPS7B Gene

Paralogs for COPS7B Gene

genes like me logo Genes that share paralogs with COPS7B: view

Variants for COPS7B Gene

Sequence variations from dbSNP and Humsavar for COPS7B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1055258 -- 231,809,127(+) TGCCC(A/C)CATAA utr-variant-3-prime
rs1055261 -- 231,809,218(+) GGGTT(C/T)TGTTA utr-variant-3-prime
rs1246014 -- 231,808,222(+) ACCCA(C/T)GGGTT utr-variant-3-prime
rs1554731 -- 231,790,468(-) CCATA(A/T)TACCT intron-variant, utr-variant-5-prime, upstream-variant-2KB
rs2014806 -- 231,784,943(+) GAGTA(G/T)CTGAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for COPS7B Gene

Variant ID Type Subtype PubMed ID
dgv1291e1 CNV Complex 17122850
dgv1292e1 CNV Complex 17122850
nsv428408 CNV Gain+Loss 18775914
dgv1293e1 CNV Complex 17122850
essv10235 CNV CNV 17122850
nsv3205 CNV Insertion 18451855
nsv508890 CNV Insertion 20534489
nsv511094 CNV Complex 20534489

Variation tolerance for COPS7B Gene

Residual Variation Intolerance Score: 52.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COPS7B Gene

HapMap Linkage Disequilibrium report
COPS7B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COPS7B Gene

Disorders for COPS7B Gene

Relevant External Links for COPS7B

Genetic Association Database (GAD)
COPS7B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COPS7B
genes like me logo Genes that share disorders with COPS7B: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COPS7B Gene

Publications for COPS7B Gene

  1. The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex. (PMID: 9707402) Wei N. … Deng X.W. (Curr. Biol. 1998) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  5. The COP9 signalosome interacts with and regulates interferon regulatory factor 5 protein stability. (PMID: 23275442) Korczeniewska J. … Barnes B.J. (Mol. Cell. Biol. 2013) 67

Products for COPS7B Gene

Sources for COPS7B Gene

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