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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

COPS7B Gene

protein-coding   GIFtS: 48
GCID: GC02P232646

COP9 Signalosome Subunit 7B

(Previous names: COP9 (constitutive photomorphogenic, Arabidopsis, homolog)...)
  Search for COPS7B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
COP9 Signalosome Subunit 7B1 2     COP9 (Constitutive Photomorphogenic, Arabidopsis, Homolog) Subunit 7B1
Signalosome Subunit 7b2 3     COP9 Constitutive Photomorphogenic Homolog Subunit 7B (Arabidopsis)1
CSN7B2 3     COP9 Constitutive Photomorphogenic Homolog Subunit 7B2
SGN7b2 3     COP9 Signalosome Complex Subunit 7b2
JAB1-Containing Signalosome Subunit 7b2 3     

External Ids:    HGNC: 167601   Entrez Gene: 647082   Ensembl: ENSG000001445247   UniProtKB: Q9H9Q23   

Export aliases for COPS7B gene to outside databases

Previous GC identifers: GC02P230710 GC02P231382 GC02P232610 GC02P232853 GC02P232476 GC02P232359 GC02P224495


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for COPS7B Gene: 
COPS7B (COP9 signalosome subunit 7B) is a protein-coding gene. An important paralog of this gene is COPS7A.

UniProtKB/Swiss-Prot: CSN7B_HUMAN, Q9H9Q2
Function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and
developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by
mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl
ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation
of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD
kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system,
respectively

Gene Wiki entry for COPS7B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the COPS7B gene promoter:
         HNF-4alpha2   HNF-4alpha1   NF-AT   NF-AT4   NF-AT2   POU2F1a   FOXJ2 (long isoform)   NF-AT3   FOXJ2   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOPS7B promoter sequence
   Search SABiosciences Chromatin IP Primers for COPS7B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COPS7B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.1   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37.1

COPS7B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COPS7B gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P232646:  view genomic region     (about GC identifiers)

Start:
232,646,381 bp from pter      End:
232,673,963 bp from pter
Size:
27,583 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CSN7B_HUMAN, Q9H9Q2 (See protein sequence)
Recommended Name: COP9 signalosome complex subunit 7b  
Size: 264 amino acids; 29622 Da
Subunit: Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or
COPS7B) and COPS8. In the complex, it probably interacts directly with COPS1, COPS2, COPS4, COPS5, COPS6 and
COPS8
Subcellular location: Cytoplasm. Nucleus
Secondary accessions: Q53S22 Q5BJG3 Q9H7V6
Alternative splicing: 3 isoforms:  Q9H9Q2-1   Q9H9Q2-2   Q9H9Q2-3   (Contains a phosphothreonine at position 261. Contains a phosphoserine at position 263)

Explore the universe of human proteins at neXtProt for COPS7B: NX_Q9H9Q2

Explore proteomics data for COPS7B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H9Q2

  • COPS7B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    COPS7B Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001269878.1  NP_001269879.1  NP_001269880.1  NP_001269881.1  NP_073567.1  

    ENSEMBL proteins: 
     ENSP00000386567   ENSP00000386438   ENSP00000386527   ENSP00000401682   ENSP00000401235  
     ENSP00000272995   ENSP00000412548   ENSP00000401211   ENSP00000401110   ENSP00000409591  
     ENSP00000391207   ENSP00000386880   ENSP00000388499   ENSP00000362710   ENSP00000400739  
     ENSP00000403300  

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    Browse Sino Biological Recombinant Proteins
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for COPS7B 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0008180COP9 signalosome IDA18850735

    COPS7B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR027530 Csn7
     IPR000717 PCI_dom

    Graphical View of Domain Structure for InterPro Entry Q9H9Q2

    ProtoNet protein and cluster: Q9H9Q2

    1 Blocks protein domain: IPB000717 Domain in components of the proteasome

    UniProtKB/Swiss-Prot: CSN7B_HUMAN, Q9H9Q2
    Similarity: Belongs to the CSN7/EIF3M family. CSN7 subfamily
    Similarity: Contains 1 PCI domain


    COPS7B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CSN7B_HUMAN, Q9H9Q2
    Function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and
    developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by
    mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl
    ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation
    of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD
    kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system,
    respectively

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    COPS7B for ontologies           About GeneDecksing


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    SwitchGear 3'UTR luciferase reporter plasmidCOPS7B 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for COPS7B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/25 Interacting proteins for COPS7B (Q9H9Q23 ENSP000002729954) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COPS5Q929053, ENSP000003505124I2D: score=3 STRING: ENSP00000350512
    COPS3Q9UNS23, ENSP000002687174I2D: score=1 STRING: ENSP00000268717
    COPS8Q996273, ENSP000003463404I2D: score=1 STRING: ENSP00000346340
    GPS1Q130983, ENSP000003472514I2D: score=1 STRING: ENSP00000347251
    COPS6Q7L5N13, ENSP000003041024I2D: score=2 STRING: ENSP00000304102
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010388cullin deneddylation IDA19141280

    COPS7B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for COPS7B (CSN7B)

    Search CenterWatch for drugs/clinical trials and news about COPS7B / CSN7B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for COPS7B gene (5 alternative transcripts): 
    NM_001282949.1  NM_001282950.1  NM_001282951.1  NM_001282952.1  NM_022730.2  

    Unigene Cluster for COPS7B:

    COP9 signalosome subunit 7B
    Hs.335061  [show with all ESTs]
    Unigene Representative Sequence: AK126326
    18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000410024 ENST00000409295 ENST00000409091 ENST00000479430 ENST00000452375
    ENST00000449784 ENST00000466901 ENST00000350033(uc010fxy.1 uc002vsg.1)
    ENST00000412591 ENST00000413197(uc002vsi.1) ENST00000450501 ENST00000357490
    ENST00000432387 ENST00000492423 ENST00000410017 ENST00000412922 ENST00000373608(uc002vsh.1)
    ENST00000436564
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    Additional mRNA sequence: 

    AK022674.1 AK024273.1 AK098334.1 AK124133.1 AK126326.1 AK222879.1 AK307486.1 BC010739.1 
    BC091493.1 

    24/32 DOTS entries (see all 32):

    DT.100660759  DT.120961240  DT.95101842  DT.100660760  DT.95101843  DT.91766031  DT.209216  DT.95101840 
    DT.100660755  DT.120961230  DT.40126401  DT.120961278  DT.97805204  DT.120961294  DT.95347528  DT.91941986 
    DT.97825217  DT.100839717  DT.120961290  DT.120961300  DT.100026987  DT.100802312  DT.120961216  DT.120961228 

    24/163 AceView cDNA sequences (see all 163):

    BP372396 BQ953525 BM698297 CB850652 BX281818 BX333333 AK098334 CR607579 
    AU125432 CD358808 BU632740 BF939657 AW006694 AK126326 AI150525 CA390578 
    AI422792 CR591213 CF139243 BU631172 BM788837 BM471793 AA976575 AL599108 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for COPS7B (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b
    SP1:                          -     -                 -     -     -           -     -                                   -                           
    SP2:                          -     -                 -     -     -           -     -                                   -     -                     
    SP3:                          -     -                 -     -     -           -     -                                                               
    SP4:                                -                 -     -     -           -                                         -     -                     
    SP5:                          -     -                 -     -     -     -     -     -                                   -     -                     


    ECgene alternative splicing isoforms for COPS7B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    COPS7B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGCCCCCTG
    COPS7B Expression
    About this image


    See COPS7B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for COPS7B

    SOURCE GeneReport for Unigene cluster: Hs.335061
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for COPS7B gene from 8/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cops7b1 , 5 COP9 (constitutive photomorphogenic) homolog, subunit more1, 5 92.68(n)1
    98.11(a)1
      1 (43.97 cM)5
    268951  NM_172974.21  NP_766562.11 
     865829045 
    chicken
    (Gallus gallus)
    Aves COPS7B1 COP9 constitutive photomorphogenic homolog subunit more 81.19(n)
    92.05(a)
      424933  XM_422740.3  XP_422740.3 
    lizard
    (Anolis carolinensis)
    Reptilia COPS7B6
    Uncharacterized protein
    93(a)
    1 ↔ 1
    GL343304.1(1020499-1037940)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.172352 Xenopus laevis transcribed sequence with moderate similarity more 75.42(n)    BU908273.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa19h062 Danio rerio cDNA clone IMAGE4786730, partial cds 76.14(n)    BC059697.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CSN7b3
    CSN71
    COP9 complex homolog subunit 71 44(a)3
    52.79(n)1
    44.75(a)1
      44C63
    358161  NM_136535.21  NP_610379.21 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons FUS51 COP9 signalosome complex subunit 7 46.61(n)
    37.56(a)
      839241  NM_202010.2  NP_973739.1 
    rice
    (Oryza sativa)
    Liliopsida Os07g04908001 hypothetical protein 47.77(n)
    36.08(a)
      4343271  NM_001066213.1  NP_001059678.1 


    ENSEMBL Gene Tree for COPS7B (if available)
    TreeFam Gene Tree for COPS7B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for COPS7B gene
    COPS7A2  
    7 SIMAP similar genes for COPS7B using alignment to 12 protein entries:     CSN7B_HUMAN (see all proteins):
    TMEM145    RANBP3    HDGFRP2    NDUFA7    LOC284385    COPS7A
    TBC1D22A

    COPS7B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/449 SNPs in COPS7B are shown (see all 449)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1431203511,2
    --232649167(+) AGCCGC/TGGTGA 1 -- us2k10--------
    rs1466620711,2
    --232649203(+) GAAAAA/CAAAAC 1 -- us2k10--------
    rs1165568081,2
    F--232649235(+) CAGCCA/GTGGAG 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs1391407311,2
    --232649283(+) GAATTG/TCTATG 1 -- us2k10--------
    rs1441370071,2
    --232649351(+) ATAGCC/GCTGTT 1 -- us2k10--------
    rs767645861,2
    F--232649373(+) AGCTCT/CAGACA 1 -- us2k11Minor allele frequency- C:0.03NA 120
    rs1451305611,2
    C--232649613(+) CACCTA/CCTGGG 1 -- us2k10--------
    rs20148061,2
    F,A--232649653(+) GAGTAG/TCTGAG 1 -- us2k11Minor allele frequency- T:0.03EA 120
    rs20148071,2
    F,A--232649654(+) AGTAGC/TTGAGA 1 -- us2k11Minor allele frequency- T:0.02EA 120
    rs1845933651,2
    --232649757(+) CTCAGA/GTGATC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for COPS7B (232646381 - 232673963 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for COPS7B:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv3205CNV Insertion18451855
    nsv508890CNV Insertion20534489
    nsv428408CNV Gain+Loss18775914
    essv10235CNV CNV17122850
    dgv1291e1CNV Complex17122850
    dgv1292e1CNV Complex17122850
    nsv511094CNV Complex20534489
    dgv1293e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    COPS7B for disorders           About MalaCards

    COPS7B for disorders           About GeneDecksing

    Genetic Association Database (GAD): COPS7B

    Export disorders for COPS7B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for COPS7B gene, integrated from 9 sources (see all 43):
    (articles sorted by number of sources associating them with COPS7B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (2008)
    2. Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. (PubMed id 18850735)1, 2 Fang L.... Huang L. (2008)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome. (PubMed id 12628923)1, 2 Uhle S....Dubiel W. (2003)
    6. The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. (PubMed id 12732143)1, 2 Groisman R.... Nakatani Y. (2003)
    7. Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome. (PubMed id 12220626)1, 2 Hoareau Alves K.... Jalinot P. (2002)
    8. Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. (PubMed id 11337588)1, 2 Lyapina S.... Deshaies R.J. (2001)
    9. COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system. (PubMed id 11285227)1, 2 Bech-Otschir D.... Dubiel W. (2001)
    10. The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex. (PubMed id 9707402)1, 3 Wei N....Deng X.W. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64708 HGNC: 16760 AceView: COPS7B Ensembl:ENSG00000144524 euGenes: HUgn64708
    ECgene: COPS7B H-InvDB: COPS7B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for COPS7B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for COPS7B gene:
    Search GeneIP for patents involving COPS7B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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