Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

COPS7A Gene

protein-coding   GIFtS: 50
GCID: GC12P006833

COP9 Signalosome Subunit 7A

(Previous names: COP9 (constitutive photomorphogenic, Arabidopsis, homolog)...)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
COP9 Signalosome Subunit 7A1 2     COP9 (Constitutive Photomorphogenic, Arabidopsis, Homolog) Subunit 7A1
Dermal Papilla-Derived Protein 102 3     COP9 Constitutive Photomorphogenic Homolog Subunit 7A (Arabidopsis)1
Signalosome Subunit 7a2 3     COP9 Complex Subunit 7a2
CSN7A2 3     COP9 Constitutive Photomorphogenic Homolog Subunit 7A2
SGN7a2 3     COP9 Signalosome Complex Subunit 7a2
JAB1-Containing Signalosome Subunit 7a2 3     DERP103

External Ids:    HGNC: 167581   Entrez Gene: 508132   Ensembl: ENSG000001116527   UniProtKB: Q9UBW83   

Export aliases for COPS7A gene to outside databases

Previous GC identifers: GC12M006747 GC12M006872 GC12P006712 GC12P006703


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for COPS7A Gene: 
COPS7A (COP9 signalosome subunit 7A) is a protein-coding gene. Diseases associated with COPS7A include xeroderma pigmentosum. An important paralog of this gene is COPS7B.

UniProtKB/Swiss-Prot: CSN7A_HUMAN, Q9UBW8
Function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and
developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by
mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl
ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation
of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD
kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system,
respectively

Gene Wiki entry for COPS7A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009759.16  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the COPS7A gene promoter:
         Max1   ATF-2   RORalpha1   CREB   FOXO4   deltaCREB   FOXJ2 (long isoform)   FOXJ2   ATF6   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOPS7A promoter sequence
   Search SABiosciences Chromatin IP Primers for COPS7A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COPS7A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.31   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.31

COPS7A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COPS7A gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P006833:  view genomic region     (about GC identifiers)

Start:
6,832,907 bp from pter      End:
6,841,041 bp from pter
Size:
8,135 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CSN7A_HUMAN, Q9UBW8 (See protein sequence)
Recommended Name: COP9 signalosome complex subunit 7a  
Size: 275 amino acids; 30277 Da
Subunit: Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or
COPS7B) and COPS8. In the complex, it probably interacts directly with COPS1, COPS2, COPS4, COPS5, COPS6 and
COPS8. Interacts with PMF1. Interacts with the translation initiation factor EIF3S6. Interacts with CK2 and PKD.
Interacts directly with ID3
Subcellular location: Cytoplasm. Nucleus
Secondary accessions: A8K9A6 Q9NVX3 Q9UJW4

Explore the universe of human proteins at neXtProt for COPS7A: NX_Q9UBW8

Explore proteomics data for COPS7A at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by CK2 and PKD kinases
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UBW8

  • COPS7A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    COPS7A Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001157565.1  NP_001157566.1  NP_001157567.1  NP_057403.1  

    ENSEMBL proteins: 
     ENSP00000438115   ENSP00000387787   ENSP00000229251   ENSP00000441852   ENSP00000443628  
     ENSP00000439547   ENSP00000438571   ENSP00000444807   ENSP00000440020   ENSP00000438352  
     ENSP00000439949   ENSP00000446039   ENSP00000473363   ENSP00000440972   ENSP00000442613  
     ENSP00000438363   ENSP00000440683   ENSP00000439158   ENSP00000445300  

    Human Recombinant Protein Products for COPS7A: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for COPS7A
    GenScript Custom Purified and Recombinant Proteins Services for COPS7A
    Novus Biologicals COPS7A Protein
    Novus Biologicals COPS7A Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for COPS7A 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0008180COP9 signalosome IDA18850735

    COPS7A for ontologies           About GeneDecksing



    COPS7A Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for COPS7A
    OriGene Custom Antibody Services for COPS7A
    GenScript Custom Superior Antibodies Services for COPS7A
    Novus Biologicals COPS7A Antibodies
    Abcam antibodies for COPS7A
    Cloud-Clone Corp. Antibodies for COPS7A 
    Search ThermoFisher Antibodies for COPS7A
    LSBio Antibodies in human, mouse, rat for COPS7A 

    Assay Products for COPS7A: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for COPS7A
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for COPS7A
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for COPS7A 
    Cloud-Clone Corp. CLIAs for COPS7A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR000717 PCI_dom

    Graphical View of Domain Structure for InterPro Entry Q9UBW8

    ProtoNet protein and cluster: Q9UBW8

    UniProtKB/Swiss-Prot: CSN7A_HUMAN, Q9UBW8
    Similarity: Belongs to the CSN7/EIF3M family. CSN7 subfamily
    Similarity: Contains 1 PCI domain


    COPS7A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CSN7A_HUMAN, Q9UBW8
    Function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and
    developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by
    mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl
    ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation
    of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD
    kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system,
    respectively

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    COPS7A for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for COPS7A:
     Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for COPS7A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for COPS7A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for COPS7A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for COPS7A 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COPS7A
    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate COPS7A (see all 22):
    hsa-miR-142-3p hsa-miR-376b hsa-miR-330-5p hsa-miR-15a hsa-miR-548k hsa-miR-624* hsa-miR-3921 hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmidCOPS7A 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for COPS7A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COPS7A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for COPS7A
    Sirion Biotech Customized adenovirus for overexpression of COPS7A

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for COPS7A (see all 19)
    OriGene ORF clones in mouse, rat for COPS7A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): COPS7A (NM_016319)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COPS7A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COPS7A
    Sirion Biotech Customized lentivirus for stable overexpression of COPS7A 
                         Customized lentivirus expression plasmids for stable overexpression of COPS7A 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for COPS7A
    Search LifeMap BioReagents cell lines for COPS7A
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPS7A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for COPS7A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/57 Interacting proteins for COPS7A (Q9UBW82, 3 ENSP000002292514) via UniProtKB, MINT, STRING, and/or I2D (see all 57)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TOM1L1O756742, 3, ENSP000004089584MINT-65693 I2D: score=5 STRING: ENSP00000408958
    COPS3Q9UNS22, 3, ENSP000002687174MINT-7230300 I2D: score=4 STRING: ENSP00000268717
    COPS5Q929052, 3, ENSP000003505124MINT-7230300 I2D: score=4 STRING: ENSP00000350512
    COPS8Q996272, 3, ENSP000003463404MINT-7230300 I2D: score=3 STRING: ENSP00000346340
    PPBPP027752, 3MINT-65694 I2D: score=5 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010388cullin deneddylation IDA19141280

    COPS7A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for COPS7A (CSN7A)

    Search CenterWatch for drugs/clinical trials and news about COPS7A / CSN7A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for COPS7A gene (4 alternative transcripts): 
    NM_001164093.1  NM_001164094.1  NM_001164095.1  NM_016319.2  

    Unigene Cluster for COPS7A:

    COP9 signalosome subunit 7A
    Hs.530823  [show with all ESTs]
    Unigene Representative Sequence: NM_001164093
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000543155(uc001qqj.3) ENST00000455113 ENST00000542150 ENST00000229251
    ENST00000539735(uc001qqi.3) ENST00000543170 ENST00000538410 ENST00000540408
    ENST00000537022 ENST00000543939 ENST00000538375 ENST00000544725 ENST00000534947(uc001qqn.4)
    ENST00000536872 ENST00000546229 ENST00000541866 ENST00000534877 ENST00000538753

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COPS7A
    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate COPS7A (see all 22):
    hsa-miR-142-3p hsa-miR-376b hsa-miR-330-5p hsa-miR-15a hsa-miR-548k hsa-miR-624* hsa-miR-3921 hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmidCOPS7A 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for COPS7A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COPS7A
    Clone
    Products:
         
    OriGene clones in human, mouse for COPS7A (see all 19)
    OriGene ORF clones in mouse, rat for COPS7A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): COPS7A (NM_016319)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COPS7A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COPS7A
    Sirion Biotech Customized lentivirus for stable overexpression of COPS7A 
                         Customized lentivirus expression plasmids for stable overexpression of COPS7A 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for COPS7A
    OriGene qSTAR qPCR primer pairs in human, mouse for COPS7A
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat COPS7A
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COPS7A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COPS7A

    Additional mRNA sequence: 

    AB014764.1 AB033603.1 AF193844.1 AF210052.1 AK001318.1 AK021721.1 AK022488.1 AK128792.1 
    AK292621.1 BC011789.2 BC093015.1 

    24/29 DOTS entries (see all 29):

    DT.101985555  DT.95259836  DT.91807594  DT.100852033  DT.91776382  DT.91776373  DT.100770390  DT.91979880 
    DT.91776414  DT.100852010  DT.100852018  DT.100852025  DT.100644116  DT.100761858  DT.121207116  DT.99951923 
    DT.95259852  DT.40125977  DT.91689343  DT.97853460  DT.100852021  DT.100852026  DT.121207106  DT.121207121 

    24/29 AceView cDNA sequences (see all 29):

    CR599521 CR605577 CR594015 CR592602 CR605258 CR619642 CR603520 AB014764 
    CR622122 CR592980 CR620296 CR591390 CR614333 CR613057 CR621364 BC011789 
    CR623628 CR603662 AB033603 CR605450 CR596731 CR620180 AK128792 AK021721 

    GeneLoc Exon Structure

    5/19 Alternative Splicing Database (ASD) splice patterns (SP) for COPS7A (see all 19)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d ^ 12 ^ 13a · 13b · 13c ·
    SP1:                          -     -     -     -     -     -     -           -     -     -     -                                                               
    SP2:                                -     -     -     -     -     -           -     -     -     -                                                               
    SP3:                                -     -     -     -     -     -           -     -     -     -                                               -     -     -   
    SP4:                                                              -           -     -     -     -                                                               
    SP5:                          -     -     -     -     -     -     -           -     -     -     -     -                                                         

    ExUns: 13d · 13e ^ 14a · 14b
    SP1:                        
    SP2:                        
    SP3:  -     -               
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for COPS7A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    COPS7A expression in normal human tissues (normalized intensities)      COPS7A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGAGAGATG
    COPS7A Expression
    About this image


    COPS7A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/32 selected tissues (see all 32) fully expand
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Epithelium (Uncategorized)    fully expand to see all 4 entries
             vagina ; squamous epithelial cells   
     
     Uterus (Reproductive System)    fully expand to see all 4 entries
             uterus, pre-menopause ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex

    See COPS7A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for COPS7A

    SOURCE GeneReport for Unigene cluster: Hs.530823

    UniProtKB/Swiss-Prot: CSN7A_HUMAN, Q9UBW8
    Tissue specificity: Widely expressed. Expressed at high level in brain, heart and skeletal muscle

        SABiosciences Custom PCR Arrays for COPS7A
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for COPS7A
    OriGene qSTAR qPCR primer pairs in human, mouse for COPS7A
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat COPS7A
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COPS7A
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COPS7A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPS7A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for COPS7A gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cops7a1 , 5 COP9 (constitutive photomorphogenic) homolog, subunit more1, 5 91.27(n)1
    98.91(a)1
      6 (59.17 cM)5
    268941  NM_012003.21  NP_036133.11 
     1249584135 
    chicken
    (Gallus gallus)
    Aves COPS7A1 COP9 constitutive photomorphogenic homolog subunit more 76.85(n)
    88.73(a)
      418283  NM_001030775.1  NP_001025946.1 
    lizard
    (Anolis carolinensis)
    Reptilia COPS7A6
    COP9 signalosome subunit 7A
    81(a)
    1 ↔ 1
    GL343453.1(44780-53492)
    zebrafish
    (Danio rerio)
    Actinopterygii cops7a6
    COP9 constitutive photomorphogenic homolog subunit...
    52(a)
    1 ↔ 1
    16(23936933-23962555)
    fruit fly
    (Drosophila melanogaster)
    Insecta CSN7b3   -- 43(a)   44C6   --


    ENSEMBL Gene Tree for COPS7A (if available)
    TreeFam Gene Tree for COPS7A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for COPS7A gene
    COPS7B2  
    1 SIMAP similar gene for COPS7A using alignment to 10 protein entries:     CSN7A_HUMAN (see all proteins):
    COPS7B

    COPS7A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/270 SNPs in COPS7A are shown (see all 270)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs605145311,2
    C--6687682(+) TTTTT-/T/TT  
            
    GAGAC
    4 -- int11NA 2
    rs1827731131,2
    --6831204(+) AAAAAG/TTAGCC 2 -- us2k10--------
    rs1464222801,2
    --6831312(+) TGTGCC/TGCTGC 3 -- us2k10--------
    rs2022206971,2
    --6831350(+) GTCTC-/AAAAAA 3 -- us2k10--------
    rs556952591,2
    C--6831481(+) AAAAA-/A/A   
       A
    /AAA
    GTAAA
    4 -- us2k11NA 2
    rs1888642731,2
    --6831553(+) CTTCAC/TCTTAC 4 -- us2k10--------
    rs123046371,2
    C--6831701(+) aacccC/Tgtctc 4 -- us2k10--------
    rs116146681,2
    C,H--6831727(+) aattaC/Gccggg 4 -- us2k10--------
    rs123177351,2
    F--6831730(+) tagccG/Aggcgt 4 -- us2k12Minor allele frequency- A:0.00NA 4
    rs1134258841,2
    C,F--6831750(+) CGCCTG/ATAGTC 4 -- us2k11Minor allele frequency- A:0.50WA 2

    HapMap Linkage Disequilibrium report for COPS7A (6832907 - 6841041 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for COPS7A:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv525884CNV Loss19592680
    nsv898635CNV Loss21882294
    nsv524621CNV Loss19592680
    nsv832323CNV Loss17160897
    nsv832322CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing COPS7A
    DNA2.0 Custom Variant and Variant Library Synthesis for COPS7A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for COPS7A:    About MalaCards
    xeroderma pigmentosum    


    COPS7A for disorders           About GeneDecksing


    Export disorders for COPS7A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for COPS7A gene, integrated from 9 sources (see all 48):
    (articles sorted by number of sources associating them with COPS7A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. (PubMed id 18850735)1, 2 Fang L.... Huang L. (2008)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome. (PubMed id 12628923)1, 2 Uhle S....Dubiel W. (2003)
    5. The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. (PubMed id 12732143)1, 2 Groisman R.... Nakatani Y. (2003)
    6. Polyamine-modulated factor 1 binds to the human homologue of the 7a subunit of the Arabidopsis COP9 signalosome: implications in gene expression. (PubMed id 12020345)1, 2 Wang Y.... Casero R.A. Jr. (2002)
    7. Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome. (PubMed id 12220626)1, 2 Hoareau Alves K.... Jalinot P. (2002)
    8. Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. (PubMed id 11337588)1, 2 Lyapina S.... Deshaies R.J. (2001)
    9. COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system. (PubMed id 11285227)1, 2 Bech-Otschir D.... Dubiel W. (2001)
    10. A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. (PubMed id 9535219)1, 2 Seeger M....Dubiel W. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 50813 HGNC: 16758 AceView: COPS7A Ensembl:ENSG00000111652 euGenes: HUgn50813
    ECgene: COPS7A H-InvDB: COPS7A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for COPS7A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for COPS7A gene:
    Search GeneIP for patents involving COPS7A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for COPS7A   OriGene RNAi products in human, mouse, rat for COPS7A  
     OriGene qPCR primer pairs and template standards for COPS7A   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for COPS7A  
     OriGene qSTAR qPCR primer pairs in human, mouse for COPS7A   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for COPS7A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for COPS7A   OriGene Custom Protein Services for COPS7A  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat COPS7A
     QIAGEN SeqTarget long-range PCR primers for resequencing COPS7A
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COPS7A
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COPS7A
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COPS7A
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COPS7A
     GenScript Custom Purified and Recombinant Proteins Services for COPS7A GenScript cDNA clones with any tag delivered in your preferred vector for COPS7A
     GenScript Custom Assay Services for COPS7A GenScript Custom Superior Antibodies Services for COPS7A
     GenScript Custom overexpressing Cell Line Services for COPS7A CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in COPS7A promoter
     Search Chromatin IP Primers for COPS7A
     RT2 qPCR Primer Assay in human, mouse, rat COPS7A
     Search GNC Networks for COPS7A
     SABiosciences Custom PCR Arrays for COPS7A
     Search Tocris compounds for COPS7A (CSN7A)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     COPS7A antibodies
     COPS7A proteins
     COPS7A lysates
     Antibodies for COPS7A
     See all of Abcam's Antibodies, Kits and Proteins for COPS7A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for COPS7A
     Antibodies for COPS7A
     ELISAs for COPS7A
     CLIAs for COPS7A
     Search LifeMap BioReagents cell lines for COPS7A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPS7A
     SwitchGear 3'UTR luciferase reporter plasmids for COPS7A
     SwitchGear Promoter luciferase reporter plasmids for COPS7A
     Search ThermoFisher Antibodies for COPS7A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COPS7A
     inGenious Targeting Laboratory - Custom generated mouse model solutions for COPS7A
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for COPS7A
    Customized:
     lentivirus for stable overexpression of COPS7A
     lentivirus expression plasmids for stable overexpression of COPS7A
     adenovirus for overexpression of COPS7A
     LSBio Antibodies in human, mouse, rat for COPS7A
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      COPS7A gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4