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Aliases for COPS7A Gene

Aliases for COPS7A Gene

  • COP9 Signalosome Subunit 7A 2 3
  • JAB1-Containing Signalosome Subunit 7a 3 4
  • Dermal Papilla-Derived Protein 10 3 4
  • CSN7A 3 4
  • SGN7a 3 4
  • COP9 (Constitutive Photomorphogenic, Arabidopsis, Homolog) Subunit 7A 2
  • COP9 Constitutive Photomorphogenic Homolog Subunit 7A (Arabidopsis) 2
  • COP9 Constitutive Photomorphogenic Homolog Subunit 7A 3
  • COP9 Signalosome Complex Subunit 7a 3
  • COP9 Complex Subunit 7a 3
  • Signalosome Subunit 7a 4
  • DERP10 4
  • CSN7 3

External Ids for COPS7A Gene

Previous GeneCards Identifiers for COPS7A Gene

  • GC12M006747
  • GC12M006872
  • GC12P006712
  • GC12P006703
  • GC12P006833

Summaries for COPS7A Gene

Entrez Gene Summary for COPS7A Gene

  • This gene encodes a component of the COP9 signalosome, an evolutionarily conserved multi-subunit protease that regulates the activity of the ubiquitin conjugation pathway. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Mar 2014]

GeneCards Summary for COPS7A Gene

COPS7A (COP9 Signalosome Subunit 7A) is a Protein Coding gene. An important paralog of this gene is COPS7B.

UniProtKB/Swiss-Prot for COPS7A Gene

  • Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Gene Wiki entry for COPS7A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COPS7A Gene

Genomics for COPS7A Gene

Regulatory Elements for COPS7A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for COPS7A Gene

Start:
6,723,741 bp from pter
End:
6,731,875 bp from pter
Size:
8,135 bases
Orientation:
Plus strand

Genomic View for COPS7A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COPS7A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COPS7A Gene

Proteins for COPS7A Gene

  • Protein details for COPS7A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBW8-CSN7A_HUMAN
    Recommended name:
    COP9 signalosome complex subunit 7a
    Protein Accession:
    Q9UBW8
    Secondary Accessions:
    • A8K9A6
    • Q9NVX3
    • Q9UJW4

    Protein attributes for COPS7A Gene

    Size:
    275 amino acids
    Molecular mass:
    30277 Da
    Quaternary structure:
    • Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS1, COPS2, COPS4, COPS5, COPS6 and COPS8. Interacts with PMF1. Interacts with the translation initiation factor EIF3S6. Interacts with CK2 and PKD. Interacts directly with ID3.

    Three dimensional structures from OCA and Proteopedia for COPS7A Gene

neXtProt entry for COPS7A Gene

Proteomics data for COPS7A Gene at MOPED

Post-translational modifications for COPS7A Gene

No data available for DME Specific Peptides for COPS7A Gene

Domains for COPS7A Gene

Protein Domains for COPS7A Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9UBW8

UniProtKB/Swiss-Prot:

CSN7A_HUMAN :
  • Q9UBW8
Domain:
  • Contains 1 PCI domain.
Family:
  • Belongs to the CSN7/EIF3M family. CSN7 subfamily.
genes like me logo Genes that share domains with COPS7A: view

No data available for Gene Families for COPS7A Gene

Function for COPS7A Gene

Molecular function for COPS7A Gene

UniProtKB/Swiss-Prot Function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Gene Ontology (GO) - Molecular Function for COPS7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with COPS7A: view

Phenotypes for COPS7A Gene

GenomeRNAi human phenotypes for COPS7A:
genes like me logo Genes that share phenotypes with COPS7A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COPS7A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for COPS7A Gene

Localization for COPS7A Gene

Subcellular locations from UniProtKB/Swiss-Prot for COPS7A Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COPS7A Gene COMPARTMENTS Subcellular localization image for COPS7A gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for COPS7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0008180 COP9 signalosome IDA 18850735
genes like me logo Genes that share ontologies with COPS7A: view

Pathways for COPS7A Gene

SuperPathways for COPS7A Gene

No Data Available

Gene Ontology (GO) - Biological Process for COPS7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010388 cullin deneddylation IDA 19141280
genes like me logo Genes that share ontologies with COPS7A: view

No data available for Pathways by source for COPS7A Gene

Transcripts for COPS7A Gene

Unigene Clusters for COPS7A Gene

COP9 signalosome subunit 7A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COPS7A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COPS7A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d ^ 12 ^ 13a · 13b · 13c ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - - -
SP9: - - - - - - - - - - - - -
SP10: - - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - - - - -
SP13: - - - - - - -
SP14: - - - -
SP15: - - - - - - - - - - - - - -
SP16: - - - - - - - - - - - -
SP17: - - - - -
SP18:
SP19:

ExUns: 13d · 13e ^ 14a · 14b
SP1:
SP2:
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

Relevant External Links for COPS7A Gene

GeneLoc Exon Structure for
COPS7A
ECgene alternative splicing isoforms for
COPS7A

Expression for COPS7A Gene

mRNA expression in normal human tissues for COPS7A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COPS7A Gene

SOURCE GeneReport for Unigene cluster for COPS7A Gene Hs.530823

mRNA Expression by UniProt/SwissProt for COPS7A Gene

Q9UBW8-CSN7A_HUMAN
Tissue specificity: Widely expressed. Expressed at high level in brain, heart and skeletal muscle.
genes like me logo Genes that share expressions with COPS7A: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for COPS7A Gene

Orthologs for COPS7A Gene

This gene was present in the common ancestor of animals.

Orthologs for COPS7A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COPS7A 35
  • 99.52 (n)
  • 100 (a)
COPS7A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia COPS7A 35
  • 90.91 (n)
  • 99.64 (a)
COPS7A 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COPS7A 35
  • 92.36 (n)
  • 99.64 (a)
COPS7A 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cops7a 35
  • 91.27 (n)
  • 98.91 (a)
Cops7a 16
Cops7a 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia COPS7A 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COPS7A 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cops7a 35
  • 91.39 (n)
  • 98.91 (a)
chicken
(Gallus gallus)
Aves COPS7A 35
  • 76.85 (n)
  • 88.73 (a)
COPS7A 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COPS7A 36
  • 81 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cops7a 35
  • 61.42 (n)
  • 58.27 (a)
cops7a 36
  • 52 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CSN7 36
  • 40 (a)
OneToMany
CSN7b 37
  • 43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9499 36
  • 43 (a)
OneToMany
Species with no ortholog for COPS7A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COPS7A Gene

ENSEMBL:
Gene Tree for COPS7A (if available)
TreeFam:
Gene Tree for COPS7A (if available)

Paralogs for COPS7A Gene

Paralogs for COPS7A Gene

Selected SIMAP similar genes for COPS7A Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with COPS7A: view

Variants for COPS7A Gene

Sequence variations from dbSNP and Humsavar for COPS7A Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs9478 -- 6,731,522(+) GGAGC(C/T)AGTCT utr-variant-3-prime
rs11227 -- 6,731,205(+) AGGAG(G/T)CAAAT utr-variant-3-prime
rs871365 -- 6,730,287(-) ATAAT(C/T)CCTGC intron-variant
rs871366 -- 6,730,222(-) ctgag(C/T)gatat intron-variant
rs1882547 -- 6,730,052(-) AGCAA(C/G)AGAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COPS7A Gene

Variant ID Type Subtype PubMed ID
nsv832322 CNV Loss 17160897
nsv898635 CNV Loss 21882294
nsv832323 CNV Loss 17160897
nsv525884 CNV Loss 19592680
nsv524621 CNV Loss 19592680

Relevant External Links for COPS7A Gene

HapMap Linkage Disequilibrium report
COPS7A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COPS7A Gene

Disorders for COPS7A Gene

No disorders were found for COPS7A Gene.

No data available for UniProtKB/Swiss-Prot for COPS7A Gene

Publications for COPS7A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. (PMID: 18850735) Fang L. … Huang L. (J. Proteome Res. 2008) 3 4
  4. COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system. (PMID: 11285227) Bech-Otschir D. … Dubiel W. (EMBO J. 2001) 3 4
  5. Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. (PMID: 11337588) Lyapina S. … Deshaies R.J. (Science 2001) 3 4

Products for COPS7A Gene

Sources for COPS7A Gene

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