Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



COPS7A Gene

protein-coding   GIFtS: 51
GCID: GC12P006833

COP9 Signalosome Subunit 7A

(Previous names: COP9 (constitutive photomorphogenic, Arabidopsis, homolog)...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
COP9 Signalosome Subunit 7A1 2     COP9 Constitutive Photomorphogenic Homolog Subunit 7A (Arabidopsis)1
Dermal Papilla-Derived Protein 102 3     COP9 Complex Subunit 7a2
CSN7A2 3     COP9 Constitutive Photomorphogenic Homolog Subunit 7A2
SGN7a2 3     COP9 Signalosome Complex Subunit 7a2
JAB1-Containing Signalosome Subunit 7a2 3     DERP103
COP9 (Constitutive Photomorphogenic, Arabidopsis, Homolog) Subunit 7A1     Signalosome Subunit 7a3

External Ids:    HGNC: 167581   Entrez Gene: 508132   Ensembl: ENSG000001116527   UniProtKB: Q9UBW83   

Export aliases for COPS7A gene to outside databases

Previous GC identifers: GC12M006747 GC12M006872 GC12P006712 GC12P006703


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for COPS7A Gene:
This gene encodes a component of the COP9 signalosome, an evolutionarily conserved multi-subunit protease that
regulates the activity of the ubiquitin conjugation pathway. Alternatively spliced transcript variants that
encode the same protein have been described. (provided by RefSeq, Mar 2014)

GeneCards Summary for COPS7A Gene:
COPS7A (COP9 signalosome subunit 7A) is a protein-coding gene. Diseases associated with COPS7A include xeroderma pigmentosum, and tonsillitis. An important paralog of this gene is COPS7B.

UniProtKB/Swiss-Prot: CSN7A_HUMAN, Q9UBW8
Function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and
developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by
mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl
ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation
of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD
kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system,
respectively

Gene Wiki entry for COPS7A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000012.12  NT_009759.17  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the COPS7A gene promoter:
         Max1   ATF-2   RORalpha1   CREB   FOXO4   deltaCREB   FOXJ2 (long isoform)   FOXJ2   ATF6   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOPS7A promoter sequence
   Search Chromatin IP Primers for COPS7A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COPS7A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.31   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.31

COPS7A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COPS7A gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P006833:  view genomic region     (about GC identifiers)

Start:
6,832,907 bp from pter      End:
6,841,041 bp from pter
Size:
8,135 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CSN7A_HUMAN, Q9UBW8 (See protein sequence)
Recommended Name: COP9 signalosome complex subunit 7a  
Size: 275 amino acids; 30277 Da
Subunit: Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or
COPS7B) and COPS8. In the complex, it probably interacts directly with COPS1, COPS2, COPS4, COPS5, COPS6 and
COPS8. Interacts with PMF1. Interacts with the translation initiation factor EIF3S6. Interacts with CK2 and PKD.
Interacts directly with ID3
Secondary accessions: A8K9A6 Q9NVX3 Q9UJW4

Explore the universe of human proteins at neXtProt for COPS7A: NX_Q9UBW8

Explore proteomics data for COPS7A at MOPED

Post-translational modifications: 

  • Phosphorylated by CK2 and PKD kinases1
  • Ubiquitination2 at Lys221
  • Modification sites at PhosphoSitePlus

  • See COPS7A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001157565.1  NP_001157566.1  NP_001157567.1  NP_057403.1  

    ENSEMBL proteins: 
     ENSP00000438115   ENSP00000387787   ENSP00000229251   ENSP00000441852   ENSP00000443628  
     ENSP00000439547   ENSP00000438571   ENSP00000444807   ENSP00000440020   ENSP00000438352  
     ENSP00000439949   ENSP00000446039   ENSP00000473363   ENSP00000440972   ENSP00000442613  
     ENSP00000438363   ENSP00000440683   ENSP00000439158   ENSP00000445300  

    COPS7A Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for COPS7A
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for COPS7A
    GenScript Custom Purified and Recombinant Proteins Services for COPS7A
    Novus Biologicals COPS7A Protein
    Novus Biologicals COPS7A Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for COPS7A

    COPS7A Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for COPS7A
    OriGene Custom Antibody Services for COPS7A
    Novus Biologicals COPS7A Antibodies
    Abcam antibodies for COPS7A
    Cloud-Clone Corp. Antibodies for COPS7A
    Search ThermoFisher Antibodies for COPS7A
    LSBio Antibodies in human, mouse, rat for COPS7A

    COPS7A Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for COPS7A
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for COPS7A
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for COPS7A
    Cloud-Clone Corp. CLIAs for COPS7A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR027530 Csn7
     IPR000717 PCI_dom

    Graphical View of Domain Structure for InterPro Entry Q9UBW8

    ProtoNet protein and cluster: Q9UBW8

    UniProtKB/Swiss-Prot: CSN7A_HUMAN, Q9UBW8
    Similarity: Belongs to the CSN7/EIF3M family. CSN7 subfamily
    Similarity: Contains 1 PCI domain


    COPS7A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CSN7A_HUMAN, Q9UBW8
    Function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and
    developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by
    mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl
    ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation
    of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD
    kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system,
    respectively

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    COPS7A for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for COPS7A:
     Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for COPS7A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for COPS7A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for COPS7A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for COPS7A

    miRNA
    Products:
        
    miRTarBase miRNAs that target COPS7A:
    hsa-mir-215-5p (MIRT024503), hsa-mir-423-5p (MIRT038117), hsa-mir-24-3p (MIRT030594), hsa-mir-107 (MIRT048306), hsa-mir-30d-5p (MIRT047795), hsa-mir-361-5p (MIRT044110), hsa-mir-192-5p (MIRT026890)

    Block miRNA regulation of human, mouse, rat COPS7A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate COPS7A (see all 22):
    hsa-miR-142-3p hsa-miR-376b hsa-miR-330-5p hsa-miR-15a hsa-miR-548k hsa-miR-624* hsa-miR-3921 hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmidCOPS7A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for COPS7A
    Predesigned siRNA for gene silencing in human, mouse, rat COPS7A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for COPS7A

    Clone
    Products:
         
    OriGene clones in human, mouse for COPS7A (see all 21)
    OriGene ORF clones in mouse, rat for COPS7A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): COPS7A (NM_016319)
    Sino Biological Human cDNA Clone for COPS7A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COPS7A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COPS7A

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for COPS7A
    Browse ESI BIO Cell Lines and PureStem Progenitors for COPS7A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPS7A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CSN7A_HUMAN, Q9UBW8: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    mitochondrion2
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm IEA--
    GO:0008180COP9 signalosome IDA18850735

    COPS7A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for COPS7A
    Interactions:

        Search GeneGlobe Interaction Network for COPS7A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for COPS7A (Q9UBW82, 3 ENSP000002292514) via UniProtKB, MINT, STRING, and/or I2D (see all 61)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TOM1L1O756742, 3, ENSP000004089584MINT-65693 I2D: score=5 STRING: ENSP00000408958
    COPS3Q9UNS22, 3, ENSP000002687174MINT-7230300 I2D: score=4 STRING: ENSP00000268717
    COPS5Q929052, 3, ENSP000003505124MINT-7230300 I2D: score=4 STRING: ENSP00000350512
    COPS8Q996272, 3, ENSP000003463404MINT-7230300 I2D: score=3 STRING: ENSP00000346340
    PPBPP027752, 3MINT-65694 I2D: score=5 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010388cullin deneddylation IDA19141280

    COPS7A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for COPS7A (CSN7A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for COPS7A gene (4 alternative transcripts): 
    NM_001164093.1  NM_001164094.1  NM_001164095.2  NM_016319.3  

    Unigene Cluster for COPS7A:

    COP9 signalosome subunit 7A
    Hs.530823  [show with all ESTs]
    Unigene Representative Sequence: NM_001164093
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000543155(uc001qqj.3) ENST00000455113 ENST00000542150 ENST00000229251
    ENST00000539735(uc001qqi.3) ENST00000543170 ENST00000538410 ENST00000540408
    ENST00000537022 ENST00000543939 ENST00000538375 ENST00000544725 ENST00000534947(uc001qqn.4)
    ENST00000536872 ENST00000546229 ENST00000541866 ENST00000534877 ENST00000538753

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat COPS7A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate COPS7A (see all 22):
    hsa-miR-142-3p hsa-miR-376b hsa-miR-330-5p hsa-miR-15a hsa-miR-548k hsa-miR-624* hsa-miR-3921 hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmidCOPS7A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for COPS7A
    Predesigned siRNA for gene silencing in human, mouse, rat COPS7A
    Clone
    Products:
         
    OriGene clones in human, mouse for COPS7A (see all 21)
    OriGene ORF clones in mouse, rat for COPS7A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): COPS7A (NM_016319)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COPS7A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COPS7A
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for COPS7A
    OriGene qSTAR qPCR primer pairs in human, mouse for COPS7A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat COPS7A
      QuantiTect SYBR Green Assays in human, mouse, rat COPS7A
      QuantiFast Probe-based Assays in human, mouse, rat COPS7A

    Additional mRNA sequence: 

    AB014764.1 AB033603.1 AF193844.1 AF210052.1 AK001318.1 AK021721.1 AK022488.1 AK128792.1 
    AK292621.1 BC011789.2 BC093015.1 

    Selected DOTS entries (see all 29):

    DT.101985555  DT.95259836  DT.91807594  DT.100852033  DT.91776382  DT.91776373  DT.100770390  DT.91979880 
    DT.91776414  DT.100852010  DT.100852018  DT.100852025  DT.100644116  DT.100761858  DT.121207116  DT.99951923 
    DT.95259852  DT.40125977  DT.91689343  DT.97853460  DT.100852021  DT.100852026  DT.121207106  DT.121207121 

    Selected AceView cDNA sequences (see all 29):

    CR591390 CR613057 CR623628 CR620296 CR599521 CR592602 CR620180 CR603520 
    CR619642 CR603662 CR605258 CR621364 CR596731 CR605450 CR614333 AB014764 
    BC011789 AB033603 CR605577 CR622122 CR592980 CR594015 AK128792 NM_016319 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for COPS7A (see all 19)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d ^ 12 ^ 13a · 13b · 13c ·
    SP1:                          -     -     -     -     -     -     -           -     -     -     -                                                               
    SP2:                                -     -     -     -     -     -           -     -     -     -                                                               
    SP3:                                -     -     -     -     -     -           -     -     -     -                                               -     -     -   
    SP4:                                                              -           -     -     -     -                                                               
    SP5:                          -     -     -     -     -     -     -           -     -     -     -     -                                                         

    ExUns: 13d · 13e ^ 14a · 14b
    SP1:                        
    SP2:                        
    SP3:  -     -               
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for COPS7A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    COPS7A expression in normal human tissues (normalized intensities)      COPS7A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGAGAGATG
    COPS7A Expression
    About this image


    COPS7A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    COPS7A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    COPS7A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.530823

    UniProtKB/Swiss-Prot: CSN7A_HUMAN, Q9UBW8
    Tissue specificity: Widely expressed. Expressed at high level in brain, heart and skeletal muscle

        Custom PCR Arrays for COPS7A
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for COPS7A
    OriGene qSTAR qPCR primer pairs in human, mouse for COPS7A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat COPS7A
    QuantiTect SYBR Green Assays in human, mouse, rat COPS7A
    QuantiFast Probe-based Assays in human, mouse, rat COPS7A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPS7A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for COPS7A gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cops7a1 , 5 COP9 (constitutive photomorphogenic) homolog, subunit more1, 5 91.27(n)1
    98.91(a)1
      6 (59.17 cM)5
    268941  NM_012003.21  NP_036133.11 
     1249584135 
    chicken
    (Gallus gallus)
    Aves COPS7A1 COP9 constitutive photomorphogenic homolog subunit more 76.85(n)
    88.73(a)
      418283  NM_001030775.1  NP_001025946.1 
    lizard
    (Anolis carolinensis)
    Reptilia COPS7A6
    COP9 signalosome subunit 7A
    81(a)
    1 ↔ 1
    GL343453.1(44780-53492)
    zebrafish
    (Danio rerio)
    Actinopterygii cops7a1 COP9 constitutive photomorphogenic homolog subunit more 61.42(n)
    58.27(a)
      336736  XM_005158022.1  XP_005158079.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CSN7b3   -- 43(a)   44C6   --


    ENSEMBL Gene Tree for COPS7A (if available)
    TreeFam Gene Tree for COPS7A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for COPS7A gene
    COPS7B2  
    1 SIMAP similar gene for COPS7A using alignment to 10 protein entries:     CSN7A_HUMAN (see all proteins):
    COPS7B

    COPS7A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for COPS7A (see all 270)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs605145311,2
    C--6687682(+) TTTTT-/T/TT  
            
    GAGAC
    4 -- int11NA 2
    rs1827731131,2
    --6831204(+) AAAAAG/TTAGCC 2 -- us2k10--------
    rs1464222801,2
    --6831312(+) TGTGCC/TGCTGC 3 -- us2k10--------
    rs2022206971,2
    --6831350(+) GTCTC-/AAAAAA 3 -- us2k10--------
    rs556952591,2
    C--6831481(+) AAAAA-/A/A   
       A
    /AAA
    GTAAA
    4 -- us2k11NA 2
    rs1888642731,2
    --6831553(+) CTTCAC/TCTTAC 4 -- us2k10--------
    rs123046371,2
    C--6831701(+) aacccC/Tgtctc 4 -- us2k10--------
    rs116146681,2
    C,H--6831727(+) aattaC/Gccggg 4 -- us2k10--------
    rs123177351,2
    F--6831730(+) tagccG/Aggcgt 4 -- us2k12Minor allele frequency- A:0.00NA 4
    rs1134258841,2
    C,F--6831750(+) CGCCTG/ATAGTC 4 -- us2k11Minor allele frequency- A:0.50WA 2

    HapMap Linkage Disequilibrium report for COPS7A (6832907 - 6841041 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for COPS7A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv525884CNV Loss19592680
    nsv898635CNV Loss21882294
    nsv524621CNV Loss19592680
    nsv832323CNV Loss17160897
    nsv832322CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing COPS7A
    DNA2.0 Custom Variant and Variant Library Synthesis for COPS7A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    6 diseases for COPS7A:    About MalaCards
    xeroderma pigmentosum    tonsillitis    cerebritis    thyroiditis
    endotheliitis    prostatitis


    COPS7A for disorders           About GeneDecksing


    Export disorders for COPS7A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for COPS7A gene, integrated from 10 sources (see all 50):
    (articles sorted by number of sources associating them with COPS7A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. (PubMed id 18850735)1, 2 Fang L.... Huang L. (J. Proteome Res. 2008)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome. (PubMed id 12628923)1, 2 Uhle S....Dubiel W. (EMBO J. 2003)
    5. The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. (PubMed id 12732143)1, 2 Groisman R.... Nakatani Y. (Cell 2003)
    6. Polyamine-modulated factor 1 binds to the human homologue of the 7a subunit of the Arabidopsis COP9 signalosome: implications in gene expression. (PubMed id 12020345)1, 2 Wang Y.... Casero R.A. Jr. (Biochem. J. 2002)
    7. Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome. (PubMed id 12220626)1, 2 Hoareau Alves K.... Jalinot P. (FEBS Lett. 2002)
    8. Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. (PubMed id 11337588)1, 2 Lyapina S.... Deshaies R.J. (Science 2001)
    9. COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system. (PubMed id 11285227)1, 2 Bech-Otschir D.... Dubiel W. (EMBO J. 2001)
    10. A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. (PubMed id 9535219)1, 2 Seeger M.... Dubiel W. (FASEB J. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 50813 HGNC: 16758 AceView: COPS7A Ensembl:ENSG00000111652 euGenes: HUgn50813
    ECgene: COPS7A H-InvDB: COPS7A

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for COPS7A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for COPS7A gene:
    Search GeneIP for patents involving COPS7A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for COPS7A   OriGene RNAi products in human, mouse, rat for COPS7A  
     OriGene qPCR primer pairs and template standards for COPS7A   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for COPS7A  
     OriGene qSTAR qPCR primer pairs in human, mouse for COPS7A   OriGene Purified Protein for COPS7A  
     OriGene ORF clones in mouse, rat for COPS7A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for COPS7A   OriGene Custom Protein Services for COPS7A  

     
     
     Block miRNA regulation of human, mouse, rat COPS7A using miScript Target Protectors SeqTarget long-range PCR primers for resequencing COPS7A
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COPS7A Predesigned siRNA for gene silencing in human, mouse, rat COPS7A
     QuantiFast Probe-based Assays in human, mouse, rat COPS7A QuantiTect SYBR Green Assays in human, mouse, rat COPS7A
     Custom PCR Arrays for COPS7A Search Chromatin IP Primers for COPS7A
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat COPS7A  Search GeneGlobe Interaction Network for COPS7A
     Regulatory tfbs in COPS7A promoter
     GenScript Custom Purified and Recombinant Proteins Services for COPS7A GenScript cDNA clones with any tag delivered in your preferred vector for COPS7A
     GenScript Custom Assay Services for COPS7A GenScript Custom overexpressing Cell Line Services for COPS7A
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for COPS7A (CSN7A)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for COPS7A
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     COPS7A antibodies
     COPS7A proteins
     COPS7A lysates
     Antibodies for COPS7A
     See all of Abcam's Antibodies, Kits and Proteins for COPS7A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for COPS7A
     Antibodies for COPS7A
     ELISAs for COPS7A
     CLIAs for COPS7A



     Browse ESI BIO Cell Lines and PureStem Progenitors for COPS7A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPS7A
     SwitchGear 3'UTR luciferase reporter plasmids for COPS7A
     SwitchGear Promoter luciferase reporter plasmids for COPS7A
     Search ThermoFisher Antibodies for COPS7A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COPS7A
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for COPS7A
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for COPS7A
     LSBio Antibodies in human, mouse, rat for COPS7A
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      COPS7A gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4