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Aliases for COPS7A Gene

Aliases for COPS7A Gene

  • COP9 Signalosome Subunit 7A 2 3 5
  • JAB1-Containing Signalosome Subunit 7a 3 4
  • Dermal Papilla-Derived Protein 10 3 4
  • CSN7A 3 4
  • SGN7a 3 4
  • COP9 (Constitutive Photomorphogenic, Arabidopsis, Homolog) Subunit 7A 2
  • COP9 Constitutive Photomorphogenic Homolog Subunit 7A (Arabidopsis) 2
  • COP9 Constitutive Photomorphogenic Homolog Subunit 7A 3
  • COP9 Complex Subunit 7a 3
  • Signalosome Subunit 7a 4
  • DERP10 4
  • CSN7 3

External Ids for COPS7A Gene

Previous GeneCards Identifiers for COPS7A Gene

  • GC12M006747
  • GC12M006872
  • GC12P006712
  • GC12P006703
  • GC12P006833

Summaries for COPS7A Gene

Entrez Gene Summary for COPS7A Gene

  • This gene encodes a component of the COP9 signalosome, an evolutionarily conserved multi-subunit protease that regulates the activity of the ubiquitin conjugation pathway. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Mar 2014]

GeneCards Summary for COPS7A Gene

COPS7A (COP9 Signalosome Subunit 7A) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and Transcription-Coupled Nucleotide Excision Repair (TC-NER). An important paralog of this gene is COPS7B.

UniProtKB/Swiss-Prot for COPS7A Gene

  • Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Gene Wiki entry for COPS7A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COPS7A Gene

Genomics for COPS7A Gene

Regulatory Elements for COPS7A Gene

Promoters for COPS7A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around COPS7A on UCSC Golden Path with GeneCards custom track

Genomic Location for COPS7A Gene

Chromosome:
12
Start:
6,723,741 bp from pter
End:
6,731,875 bp from pter
Size:
8,135 bases
Orientation:
Plus strand

Genomic View for COPS7A Gene

Genes around COPS7A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COPS7A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COPS7A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COPS7A Gene

Proteins for COPS7A Gene

  • Protein details for COPS7A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBW8-CSN7A_HUMAN
    Recommended name:
    COP9 signalosome complex subunit 7a
    Protein Accession:
    Q9UBW8
    Secondary Accessions:
    • A8K9A6
    • Q9NVX3
    • Q9UJW4

    Protein attributes for COPS7A Gene

    Size:
    275 amino acids
    Molecular mass:
    30277 Da
    Quaternary structure:
    • Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS1, COPS2, COPS4, COPS5, COPS6 and COPS8. Interacts with PMF1. Interacts with the translation initiation factor EIF3S6. Interacts with CK2 and PKD. Interacts directly with ID3.

    Three dimensional structures from OCA and Proteopedia for COPS7A Gene

neXtProt entry for COPS7A Gene

Proteomics data for COPS7A Gene at MOPED

Post-translational modifications for COPS7A Gene

Antibody Products

No data available for DME Specific Peptides for COPS7A Gene

Domains & Families for COPS7A Gene

Gene Families for COPS7A Gene

Protein Domains for COPS7A Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9UBW8

UniProtKB/Swiss-Prot:

CSN7A_HUMAN :
  • Contains 1 PCI domain.
  • Belongs to the CSN7/EIF3M family. CSN7 subfamily.
Domain:
  • Contains 1 PCI domain.
Family:
  • Belongs to the CSN7/EIF3M family. CSN7 subfamily.
genes like me logo Genes that share domains with COPS7A: view

Function for COPS7A Gene

Molecular function for COPS7A Gene

UniProtKB/Swiss-Prot Function:
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
genes like me logo Genes that share phenotypes with COPS7A: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COPS7A Gene

Localization for COPS7A Gene

Subcellular locations from UniProtKB/Swiss-Prot for COPS7A Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COPS7A Gene COMPARTMENTS Subcellular localization image for COPS7A gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 2
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for COPS7A Gene

Pathways & Interactions for COPS7A Gene

genes like me logo Genes that share pathways with COPS7A: view

Gene Ontology (GO) - Biological Process for COPS7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000715 nucleotide-excision repair, DNA damage recognition TAS --
GO:0070911 global genome nucleotide-excision repair TAS --
genes like me logo Genes that share ontologies with COPS7A: view

No data available for SIGNOR curated interactions for COPS7A Gene

Drugs & Compounds for COPS7A Gene

No Compound Related Data Available

Transcripts for COPS7A Gene

Unigene Clusters for COPS7A Gene

COP9 signalosome subunit 7A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COPS7A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d ^ 12 ^ 13a · 13b · 13c ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - - -
SP9: - - - - - - - - - - - - -
SP10: - - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - - - - -
SP13: - - - - - - -
SP14: - - - -
SP15: - - - - - - - - - - - - - -
SP16: - - - - - - - - - - - -
SP17: - - - - -
SP18:
SP19:

ExUns: 13d · 13e ^ 14a · 14b
SP1:
SP2:
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

Relevant External Links for COPS7A Gene

GeneLoc Exon Structure for
COPS7A
ECgene alternative splicing isoforms for
COPS7A

Expression for COPS7A Gene

mRNA expression in normal human tissues for COPS7A Gene

Protein differential expression in normal tissues from HIPED for COPS7A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for COPS7A Gene



SOURCE GeneReport for Unigene cluster for COPS7A Gene Hs.530823

mRNA Expression by UniProt/SwissProt for COPS7A Gene

Q9UBW8-CSN7A_HUMAN
Tissue specificity: Widely expressed. Expressed at high level in brain, heart and skeletal muscle.
genes like me logo Genes that share expression patterns with COPS7A: view

Protein tissue co-expression partners for COPS7A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for COPS7A Gene

Orthologs for COPS7A Gene

This gene was present in the common ancestor of animals.

Orthologs for COPS7A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia COPS7A 35
  • 90.91 (n)
  • 99.64 (a)
COPS7A 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COPS7A 35
  • 92.36 (n)
  • 99.64 (a)
COPS7A 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cops7a 35
  • 91.27 (n)
  • 98.91 (a)
Cops7a 16
Cops7a 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia COPS7A 35
  • 99.52 (n)
  • 100 (a)
COPS7A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cops7a 35
  • 91.39 (n)
  • 98.91 (a)
oppossum
(Monodelphis domestica)
Mammalia COPS7A 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COPS7A 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves COPS7A 35
  • 76.85 (n)
  • 88.73 (a)
COPS7A 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COPS7A 36
  • 81 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cops7a 35
  • 61.42 (n)
  • 58.27 (a)
cops7a 36
  • 52 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CSN7b 37
  • 43 (a)
CSN7 36
  • 40 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9499 36
  • 43 (a)
OneToMany
Species with no ortholog for COPS7A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COPS7A Gene

ENSEMBL:
Gene Tree for COPS7A (if available)
TreeFam:
Gene Tree for COPS7A (if available)

Paralogs for COPS7A Gene

Paralogs for COPS7A Gene

(1) SIMAP similar genes for COPS7A Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with COPS7A: view

Variants for COPS7A Gene

Sequence variations from dbSNP and Humsavar for COPS7A Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs9478 -- 6,731,522(+) GGAGC(C/T)AGTCT utr-variant-3-prime
rs11227 -- 6,731,205(+) AGGAG(G/T)CAAAT utr-variant-3-prime
rs871365 -- 6,730,287(-) ATAAT(C/T)CCTGC intron-variant
rs871366 -- 6,730,222(-) ctgag(C/T)gatat intron-variant
rs1882547 -- 6,730,052(-) AGCAA(C/G)AGAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COPS7A Gene

Variant ID Type Subtype PubMed ID
nsv832322 CNV Loss 17160897
nsv898635 CNV Loss 21882294
nsv832323 CNV Loss 17160897
nsv525884 CNV Loss 19592680
nsv524621 CNV Loss 19592680

Variation tolerance for COPS7A Gene

Residual Variation Intolerance Score: 41.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.65; 13.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COPS7A Gene

HapMap Linkage Disequilibrium report
COPS7A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COPS7A Gene

Disorders for COPS7A Gene

Relevant External Links for COPS7A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COPS7A

No disorders were found for COPS7A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COPS7A Gene

Publications for COPS7A Gene

  1. Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. (PMID: 18850735) Fang L. … Huang L. (J. Proteome Res. 2008) 3 4 67
  2. Substrate trapping proteomics reveals targets of the I^TrCP2/FBXW11 ubiquitin ligase. (PMID: 25332235) Kim T.Y. … Major M.B. (Mol. Cell. Biol. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Dynamic regulation of the COP9 signalosome in response to DNA damage. (PMID: 24421388) FA1zesi-Levi M.G. … Sharon M. (Mol. Cell. Biol. 2014) 3

Products for COPS7A Gene

Sources for COPS7A Gene

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