COPS7A Gene
protein-coding GIFtS: 48
GCID: GC12P006833
|
|
COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)(Previous names: COP9 (constitutive photomorphogenic, Arabidopsis, homolog)...)
| |
Aliases
for COPS7A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| COP9 Constitutive Photomorphogenic Homolog Subunit 7A (Arabidopsis)1 2 | | JAB1-Containing Signalosome Subunit 7a2 3 | | CSN7A1 2 3 | | COP9 (Constitutive Photomorphogenic, Arabidopsis, Homolog) Subunit 7A1 | | Dermal Papilla-Derived Protein 102 3 | | COP9 Complex Subunit 7a2 | | Signalosome Subunit 7a2 3 | | COP9 Signalosome Complex Subunit 7a2 | | SGN7a2 3 | | DERP103 |
Export aliases for COPS7A gene to outside databasesPrevious GC identifers: GC12M006747 GC12M006872 GC12P006712 GC12P006703 |
Summaries
for COPS7A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CSN7A_HUMAN, Q9UBW8Function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmentalprocesses. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating thedeneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity ofSCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN,I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependentphosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively
Gene Wiki entry for COPS7A
|
Genomic Views
for COPS7A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009759.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the COPS7A gene promoter:
Max1 ATF-2 RORalpha1 CREB FOXO4 deltaCREB FOXJ2 (long isoform) FOXJ2 ATF6 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for COPS7A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COPS7A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12p13.31 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13.31COPS7A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P006833: view genomic region
(about GC identifiers)
Start:
|
6,832,907 bp from pter |
End:
|
6,841,041 bp from pter |
Size:
|
8,135 bases |
Orientation:
|
plus strand |
|
Proteins
for COPS7A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CSN7A_HUMAN, Q9UBW8 (See
protein sequence)Recommended Name: COP9 signalosome complex subunit 7a Size: 275 amino acids; 30277 Da
Subunit: Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A orCOPS7B) and COPS8. In the complex, it probably interacts directly with COPS1, COPS2, COPS4, COPS5, COPS6 and COPS8.Interacts with PMF1. Interacts with the translation initiation factor EIF3S6. Interacts with CK2 and PKD. Interactsdirectly with ID3
Subcellular location: Cytoplasm. Nucleus
Secondary accessions: A8K9A6 Q9NVX3 Q9UJW4Explore the universe of human proteins at neXtProt for COPS7A: NX_Q9UBW8
Post-translational modifications:
Phosphorylated by CK2 and PKD kinases1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UBW8
COPS7A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001157565.1 NP_001157566.1 NP_001157567.1 NP_057403.1
ENSEMBL proteins: ENSP00000438115 ENSP00000414459 ENSP00000387787 ENSP00000442598 ENSP00000229251 ENSP00000441852 ENSP00000443628 ENSP00000439547 ENSP00000438571 ENSP00000444807 ENSP00000440020 ENSP00000438352 ENSP00000439949 ENSP00000446039 ENSP00000440972 ENSP00000442613 ENSP00000438363 ENSP00000440683 ENSP00000439158 ENSP00000445300
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
COPS7A for ontologies About GeneDecksing
COPS7A Antibody Products:
Assay Products for COPS7A: |
Protein
Domains /
Families
for COPS7A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
COPS7A for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9UBW8ProtoNet protein and cluster: Q9UBW8 UniProtKB/Swiss-Prot: CSN7A_HUMAN, Q9UBW8Similarity: Belongs to the CSN7/EIF3M family. CSN7 subfamilySimilarity: Contains 1 PCI domain |
Function
for COPS7A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CSN7A_HUMAN, Q9UBW8Function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmentalprocesses. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating thedeneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity ofSCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN,I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependentphosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COPS7A (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COPS7A (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): COPS7A (NM_016319) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COPS7A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COPS7A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPS7A |
1 GenomeRNAi human phenotype for COPS7A:
|
Pathways & Interactions
for COPS7A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for COPS7A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/57 Interacting proteins for COPS7A (Q9UBW82, 3 ENSP000002292514) via UniProtKB, MINT, STRING, and/or I2D (see all 57)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
COPS7A for ontologies About GeneDecksing
|
Drugs & Compounds
for COPS7A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for COPS7A
Search CenterWatch for drugs/clinical trials and news about COPS7A / CSN7A
|
Transcripts
for COPS7A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for COPS7A gene (4 alternative transcripts): NM_001164093.1 NM_001164094.1 NM_001164095.1 NM_016319.2 Unigene Cluster for COPS7A: COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis) Hs.530823 [show with all ESTs]Unigene Representative Sequence: NM_00116409318/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24): ENST00000543155(uc001qqj.3) ENST00000442593(uc001qqh.3) ENST00000455113
ENST00000542150 ENST00000536924 ENST00000229251 ENST00000539735(uc001qqi.3)
ENST00000543170 ENST00000538410 ENST00000540408 ENST00000537022 ENST00000543939
ENST00000538375 ENST00000544725 ENST00000534947(uc001qqn.4) ENST00000537816
ENST00000536872 ENST00000546229
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COPS7A (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COPS7A (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): COPS7A (NM_016319) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COPS7A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COPS7A |
Additional cDNA sequence: AB014764.1 AB033603.1 AF193844.1 AF210052.1 AK001318.1 AK021721.1 AK022488.1 AK128792.1 AK292621.1 BC011789.2 BC093015.1 24/29 DOTS entries (see all 29): DT.101985555 DT.95259836 DT.91807594 DT.100852033 DT.91776382 DT.91776373 DT.100770390 DT.91979880 DT.91776414 DT.100852010 DT.100852018 DT.100852025 DT.100644116 DT.100761858 DT.121207116 DT.99951923 DT.95259852 DT.40125977 DT.91689343 DT.97853460 DT.100852021 DT.100852026 DT.121207106 DT.121207121 24/29 AceView cDNA sequences (see all 29): CR592602 CR603520 CR623628 CR603662 AB014764 CR591390 CR620180 CR614333 CR594015 CR620296 CR619642 CR613057 CR605258 CR621364 CR605450 CR599521 BC011789 AB033603 CR605577 CR596731 CR622122 CR592980 AK022488 AK128792
GeneLoc Exon Structure
5/19 Alternative Splicing Database (ASD) splice patterns (SP) for COPS7A (see all 19) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | · | 11d | ^ | 12 | ^ | 13a | · | 13b | · | 13c | · |
|---|
|
| SP1: | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | - | | - | | - | | - | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | - | | - | | - | | - | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | - | | - | | - | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | - | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | |
| ExUns: | 13d | · | 13e | ^ | 14a | · | 14b |
|---|
|
| SP1: | | | | | | | | | |
| SP2: | | | | | | | | | |
| SP3: | - | | - | | | | | | |
| SP4: | | | | | | | | | |
| SP5: | | | | | | | | |
ECgene alternative splicing isoforms for COPS7A
|
Expression
for COPS7A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| COPS7A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGAGAGATG
About this image
See COPS7A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for COPS7A
SOURCE GeneReport for Unigene cluster: Hs.530823
UniProtKB/Swiss-Prot: CSN7A_HUMAN, Q9UBW8Tissue specificity: Widely expressed. Expressed at high level in brain, heart and skeletal muscle
SABiosciences Custom PCR Arrays for COPS7A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COPS7A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat COPS7A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COPS7A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COPS7A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPS7A |
Orthologs
for COPS7A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for COPS7A gene from 7/23 species (see all 23) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Cops7a1 , 5 |
COP9 (constitutive photomorphogenic) homolog, subunit more1, 5 |
91.27(n)1
98.91(a)1 |
|
6 (59.17 cM)5
268941 NM_012003.21 NP_036133.11
1249584135 |
chicken
(Gallus gallus) |
Aves |
COPS7A1 |
COP9 constitutive photomorphogenic homolog subunit more |
76.85(n)
88.73(a) |
|
418283 NM_001030775.1 NP_001025946.1 |
lizard
(Anolis carolinensis) |
Reptilia |
COPS7A6 |
-- |
89(a) |
1 ↔ 1 |
GL343453.1(47703-52759) |
zebrafish
(Danio rerio) |
Actinopterygii |
cops7a6 |
COP9 constitutive photomorphogenic homolog subunit... |
51(a) |
1 → many |
16(23936933-23962555) |
fruit fly
(Drosophila melanogaster) |
Insecta |
CSN7b3 |
-- |
43(a) |
|
44C6 -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
CSN76 |
COP9 signalosome complex subunit 7 |
30(a) |
1 → many |
1(387277-389647) |
rice
(Oryza sativa) |
Liliopsida |
-- |
proteasome subunit, putative, expressed |
32(a) |
1 → many |
7(18252481-18256984) |
ENSEMBL Gene Tree for COPS7A (if available)
TreeFam Gene Tree for COPS7A (if available) |
Paralogs
for COPS7A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for COPS7A gene
- COPS7B2
1 SIMAP similar gene for COPS7A using alignment to 12 protein entries: CSN7A_HUMAN (see all proteins):COPS7B
COPS7A for paralogs About GeneDecksing
|
Genomic Variants
for COPS7A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for COPS7A (6832907 - 6841041 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for COPS7A: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COPS7A |
|
Disorders
/ Diseases
for COPS7A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for COPS7A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for COPS7A gene, integrated from 9 sources (see all 44):
(articles sorted by number of sources associating them with COPS7A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. (PubMed id 18850735)1, 2 Fang L.... Huang L. (2008)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome. (PubMed id 12628923)1, 2 Uhle S....Dubiel W. (2003)
- The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. (PubMed id 12732143)1, 2 Groisman R.... Nakatani Y. (2003)
- Polyamine-modulated factor 1 binds to the human homologue of the 7a subunit of the Arabidopsis COP9 signalosome: implications in gene expression. (PubMed id 12020345)1, 2 Wang Y.... Casero R.A. Jr. (2002)
- Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome. (PubMed id 12220626)1, 2 Hoareau Alves K.... Jalinot P. (2002)
- Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. (PubMed id 11337588)1, 2 Lyapina S.... Deshaies R.J. (2001)
- COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system. (PubMed id 11285227)1, 2 Bech-Otschir D.... Dubiel W. (2001)
- A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. (PubMed id 9535219)1, 2 Seeger M....Dubiel W. (1998)
|
External Searches for COPS7A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing COPS7A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing COPS7A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing COPS7A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for COPS7A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for COPS7A gene:
Search GeneIP for patents involving COPS7A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for COPS7A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for COPS7A | | OriGene shRNA RFP for COPS7A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COPS7A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COPS7A | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for COPS7A | | OriGene 3'-UTR Clone for COPS7A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COPS7A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COPS7A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for COPS7A | | OriGene Custom Protein Services for COPS7A | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat COPS7A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COPS7A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COPS7A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COPS7A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COPS7A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COPS7A |
| |
 |  |  |  | |
| | | | Search Tocris compounds for COPS7A |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | COPS7A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPS7A |
|  |  |  | | | | Search ThermoFisher Antibodies for COPS7A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COPS7A |
|
|
|
|
