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COPS6 Gene

protein-coding   GIFtS: 58
GCID: GC07P099686

COP9 Signalosome Subunit 6

(Previous name: COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis))
  See COPS6-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
COP9 Signalosome Subunit 61 2     COP9 Subunit 6 (MOV34 Homolog1
CSN62 3 5     H_NH0506M12.122
Signalosome Subunit 62 3     MOV34-34KD2
Vpr-Interacting Protein2 3     COP9 Constitutive Photomorphogenic Homolog Subunit 62
SGN62 3     COP9 Signalosome Complex Subunit 62
hVIP2 3     COP9 Subunit 6 (MOV34 Homolog, 34 KD)2
JAB1-Containing Signalosome Subunit 62 3     MOV34 Homolog, 34 KD2
34 KD)1     HVIP3
COP9 Constitutive Photomorphogenic Homolog Subunit 6 (Arabidopsis)1     MOV34 Homolog3

External Ids:    HGNC: 217491   Entrez Gene: 109802   Ensembl: ENSG000001680907   OMIM: 6147295   UniProtKB: Q7L5N13   

Export aliases for COPS6 gene to outside databases

Previous GC identifers: GC07P098221 GC07P099284 GC07P099298 GC07P099297 GC07P099331 GC07P099524 GC07P094322


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for COPS6 Gene:
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein
complex that functions as an important regulator in multiple signaling pathways. The structure and function of
COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been
shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases.
This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of
cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr. (provided by RefSeq, Jul
2008)

GeneCards Summary for COPS6 Gene:
COPS6 (COP9 signalosome subunit 6) is a protein-coding gene. Diseases associated with COPS6 include hiv-1. An important paralog of this gene is PSMD7.

UniProtKB/Swiss-Prot: CSN6_HUMAN, Q7L5N1
Function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and
developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by
mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl
ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation
of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD
kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system,
respectively. Has some glucocorticoid receptor-responsive activity. Stabilizes RFWD2/COP1 through reducing RFWD2
auto-ubiquitination and decelerating RFWD2 turnover rate, hence regulates the ubiquitination of RFWD2 targets

Gene Wiki entry for COPS6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the COPS6 gene promoter:
         Pax-6   Arnt   NF-AT   NF-AT4   POU2F1   NF-AT2   POU2F1a   SEF-1 (1)   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOPS6 promoter sequence
   Search Chromatin IP Primers for COPS6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COPS6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22.1

COPS6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COPS6 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P099686:  view genomic region     (about GC identifiers)

Start:
99,686,577 bp from pter      End:
99,689,823 bp from pter
Size:
3,247 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 99,046,703-99,049,943     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CSN6_HUMAN, Q7L5N1 (See protein sequence)
Recommended Name: COP9 signalosome complex subunit 6  
Size: 327 amino acids; 36163 Da
Subunit: Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or
COPS7B) and COPS8. In the complex, it probably interacts directly with COPS2, COPS4, COPS5 and COPS7 (COPS7A or
COPS7B). Interacts with the translation initiation factor EIF3S6. Interacts weakly with RBX1. Interacts with the
HIV-1 protein Vpr. Directly interacts with RFWD2 and 14-3-3 protein sigma/SFN
Caution: Although related to the peptidase M67A family, it lacks the JAMM motif that probably constitutes the
catalytic center and therefore it probably does not have a protease activity
Sequence caution: Sequence=AAD03469.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A4D2A3 O15387

Explore the universe of human proteins at neXtProt for COPS6: NX_Q7L5N1

Explore proteomics data for COPS6 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys75, Lys102, Lys117, Lys153, Lys229, Lys236, Lys243, Lys308
  • Modification sites at PhosphoSitePlus

  • See COPS6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006824.2  
    ENSEMBL proteins: 
     ENSP00000304102   ENSP00000388865   ENSP00000400617   ENSP00000413702  

    COPS6 Human Recombinant Protein Products:

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    Novus Biologicals COPS6 Proteins
    Novus Biologicals COPS6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for COPS6
    Cloud-Clone Corp. Proteins for COPS6

     
    Search eBioscience for Proteins for COPS6 

    COPS6 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for COPS6

    COPS6 Assay Products:

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    Search eBioscience for ELISAs for COPS6 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR000555 JAB_MPN_dom
     IPR024969 Rpn11/EIF3F_C

    Graphical View of Domain Structure for InterPro Entry Q7L5N1

    ProtoNet protein and cluster: Q7L5N1

    1 Blocks protein domain: IPB000555 Mov34 family

    UniProtKB/Swiss-Prot: CSN6_HUMAN, Q7L5N1
    Similarity: Belongs to the peptidase M67A family. CSN6 subfamily
    Similarity: Contains 1 MPN (JAB/Mov34) domain


    Find genes that share domains with COPS6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CSN6_HUMAN, Q7L5N1
    Function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and
    developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by
    mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl
    ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation
    of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD
    kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system,
    respectively. Has some glucocorticoid receptor-responsive activity. Stabilizes RFWD2/COP1 through reducing RFWD2
    auto-ubiquitination and decelerating RFWD2 turnover rate, hence regulates the ubiquitination of RFWD2 targets

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16169070
         
    Find genes that share ontologies with COPS6           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for COPS6:
     Decreased influenza A virus in  Decreased nuclei size in G2M  Decreased viability  Increased S DNA content 
     Increased cell death HMECs cel 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cops6):
     cellular  embryogenesis  growth/size/body  hematopoietic system  immune system 
     mortality/aging  tumorigenesis 

    Find genes that share phenotypes with COPS6           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for COPS6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for COPS6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for COPS6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for COPS6

    miRNA
    Products:
        
    miRTarBase miRNAs that target COPS6:
    hsa-mir-328-3p (MIRT043782), hsa-let-7f-5p (MIRT032093), hsa-let-7i-5p (MIRT024115), hsa-mir-92a-3p (MIRT049676), hsa-let-7c-5p (MIRT032192), hsa-let-7e-3p (MIRT032097)

    Block miRNA regulation of human, mouse, rat COPS6 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate COPS6:
    hsa-miR-185* hsa-miR-342-5p hsa-miR-26a hsa-miR-26b hsa-miR-1297
    SwitchGear 3'UTR luciferase reporter plasmidCOPS6 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for COPS6
    Predesigned siRNA for gene silencing in human, mouse, rat COPS6

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for COPS6 (see all 7)
    OriGene ORF clones in mouse, rat for COPS6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: COPS6 (NM_006833)
    Sino Biological Human cDNA Clone for COPS6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COPS6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COPS6
    Addgene plasmids for COPS6 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for COPS6
    Browse ESI BIO Cell Lines and PureStem Progenitors for COPS6 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPS6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CSN6_HUMAN, Q7L5N1: Nucleus. Cytoplasm. Note=The interaction with HIV-1 Vpr protein possibly leads its
    translocation to a perinuclear region
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton3
    cytosol1
    lysosome1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IEA--
    GO:0008180COP9 signalosome IDA18850735

    Find genes that share ontologies with COPS6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for COPS6 About    
    See pathways by source

    SuperPathContained pathways About
    1Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    NOD pathway0.33


    1 BioSystems Pathway for COPS6
        NOD pathway



        Pathway & Disease-focused RT2 Profiler PCR Array including COPS6: 
              HIV Host Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for COPS6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for COPS6 (Q7L5N11, 2, 3 ENSP000003041024) via UniProtKB, MINT, STRING, and/or I2D (see all 803)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000225987P404252, 3, ENSP000004039484MINT-62745 MINT-62669 MINT-62571 I2D: score=4 STRING: ENSP00000403948
    ENSG00000237344P404252, 3, ENSP000003971774MINT-62745 MINT-62669 MINT-62571 I2D: score=4 STRING: ENSP00000397177
    PBX2P404252, 3, ENSP000003641904MINT-62745 MINT-62669 MINT-62571 I2D: score=4 STRING: ENSP00000364190
    ENSG00000206315P404252, 3MINT-62745 MINT-62669 MINT-62571 I2D: score=4 
    ENSG00000224952P404252, 3MINT-62745 MINT-62669 MINT-62571 I2D: score=4 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010388cullin deneddylation IDA19141280
    GO:0016032viral process IEA--
    GO:0019048modulation by virus of host morphology or physiology ----

    Find genes that share ontologies with COPS6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for COPS6 (CSN6)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for COPS6 gene: 
    NM_006833.4  

    Unigene Cluster for COPS6:

    COP9 signalosome subunit 6
    Hs.15591  [show with all ESTs]
    Unigene Representative Sequence: BM542040
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000303904(uc003usu.3) ENST00000465027(uc011kjf.1) ENST00000419210
    ENST00000418625 ENST00000472107 ENST00000468499 ENST00000496358 ENST00000474823
    ENST00000426712 ENST00000483891
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat COPS6 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate COPS6:
    hsa-miR-185* hsa-miR-342-5p hsa-miR-26a hsa-miR-26b hsa-miR-1297
    SwitchGear 3'UTR luciferase reporter plasmidCOPS6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for COPS6
    Predesigned siRNA for gene silencing in human, mouse, rat COPS6
    Clone
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    OriGene clones in human, mouse for COPS6 (see all 7)
    OriGene ORF clones in mouse, rat for COPS6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: COPS6 (NM_006833)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COPS6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COPS6
    Addgene plasmids for COPS6 
    Primer
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    OriGene qPCR primer pairs and template standards for COPS6
    OriGene qSTAR qPCR primer pairs in human, mouse for COPS6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat COPS6
      QuantiTect SYBR Green Assays in human, mouse, rat COPS6
      QuantiFast Probe-based Assays in human, mouse, rat COPS6

    Additional mRNA sequence: 

    AK295237.1 AK312024.1 BC002520.2 U70735.1 

    14 DOTS entries:

    DT.95170955  DT.95315984  DT.453098  DT.100815364  DT.95170972  DT.121065250  DT.100815360  DT.121065372 
    DT.95170970  DT.121065332  DT.100815361  DT.91960947  DT.95170966  DT.95170967 

    Selected AceView cDNA sequences (see all 470):

    BF980601 BM911834 BQ722276 BQ887575 BE614146 BQ682910 BP382381 BM562635 
    AA373380 BQ675009 BM887833 BU154079 BE794682 AA641343 BE315136 CR593453 
    BU507359 AA877519 BQ778077 CD672151 BQ424490 BG324664 BE907299 AA947240 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for COPS6 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10
    SP1:                          -     -                       -                                                   
    SP2:                          -     -                       -                                                   
    SP3:                          -     -                       -     -                                             
    SP4:                    -     -     -     -     -           -     -                                             
    SP5:                          -     -                                                                           


    ECgene alternative splicing isoforms for COPS6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    COPS6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACCAGTTTG
    COPS6 Expression
    About this image


    COPS6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Kidney (Urinary System)
    COPS6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    COPS6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.15591

    UniProtKB/Swiss-Prot: CSN6_HUMAN, Q7L5N1
    Tissue specificity: Widely expressed

        Pathway & Disease-focused RT2 Profiler PCR Array including COPS6: 
              HIV Host Response in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for COPS6
    OriGene qSTAR qPCR primer pairs in human, mouse for COPS6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat COPS6
    QuantiTect SYBR Green Assays in human, mouse, rat COPS6
    QuantiFast Probe-based Assays in human, mouse, rat COPS6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPS6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for COPS6 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cops61 , 5 COP9 (constitutive photomorphogenic) homolog, subunit more1, 5 93.44(n)1
    99.05(a)1
      5 (76.97 cM)5
    268931  NM_012002.31  NP_036132.11 
     1381610715 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    98(a)
    74(a)
    1 ↔ many
    1 ↔ many
    GL343882.1(32-3055)
    LGc(2365534-2370031)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.241802 Xenopus laevis transcribed sequence with moderate similarity more 79.98(n)    CA987326.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cops61 COP9 constitutive photomorphogenic homolog subunit more 81.26(n)
    91.92(a)
      550465  NM_001017768.1  NP_001017768.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CSN61 COP9 complex homolog subunit 6 63.51(n)
    62.16(a)
      42661  NM_079727.3  NP_524451.1 
    worm
    (Caenorhabditis elegans)
    Secernentea csn-61 csn-6 48.24(n)
    37.55(a)
      178289  NM_001268796.1  NP_001255725.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPN86
    Essential, non-ATPase regulatory subunit of the 26...
    20(a)
    1 → many
    XV(815915-816931) YOR261C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CSN6A1 CSN6A 51.59(n)
    41.7(a)
      835727  NM_125011.3  NP_568839.1 
    rice
    (Oryza sativa)
    Liliopsida Os08g05000001 Os08g0500000 52.53(n)
    41.08(a)
      4345944  NM_001068687.1  NP_001062152.2 


    ENSEMBL Gene Tree for COPS6 (if available)
    TreeFam Gene Tree for COPS6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for COPS6 gene
    PSMD72  EIF3F2  

    Find genes that share paralogs with COPS6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for COPS6 (see all 140)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1888501701,2
    --99684613(+) GTGTTA/CAGTAA 1 -- us2k10--------
    rs1499398921,2
    --99684868(+) AAGCAA/GTTTGT 1 -- us2k10--------
    rs1821771261,2
    --99684893(+) GGGGAC/GGTATA 1 -- us2k10--------
    rs1871486501,2
    --99685026(+) TCGGCA/GTGCCT 1 -- us2k10--------
    rs1383023751,2
    C--99685198(+) TTATC-/TTCT  
            
    TTCTT
    1 -- us2k10--------
    rs667101501,2
    C--99685220(-) AAAAA-/AAAG/G
            
    AAAGA
    1 -- us2k11NA 2
    rs1123777081,2
    C--99685220(+) TCTTTT/CTTTTT 1 -- us2k12Minor allele frequency- C:0.25NA CSA 4
    rs1440278731,2
    C--99685309(+) TCCACC/TTCCCG 1 -- us2k10--------
    rs1904639201,2
    --99685577(+) AAGCAC/TGAGAC 1 -- us2k10--------
    rs1486524041,2
    --99685708(+) ATTCCC/TTCATT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for COPS6 (99686577 - 99689823 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for COPS6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2734888CNV Deletion23290073
    nsv469687CNV Loss16826518
    nsv510966CNV Complex20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing COPS6
    DNA2.0 Custom Variant and Variant Library Synthesis for COPS6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614729    OMIM disorders: --

    1 disease for COPS6:    
    About MalaCards
    hiv-1


    Find genes that share disorders with COPS6           About GenesLikeMe


    Export disorders for COPS6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for COPS6 gene, integrated from 10 sources (see all 79):
    (articles sorted by number of sources associating them with COPS6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Carboxyl terminus of hVIP/mov34 is critical for HIV-1-Vpr interaction and glucocorticoid-mediated signaling. (PubMed id 12237292)1, 2, 9 Ramanathan M.P.... Weiner D.B. (J. Biol. Chem. 2002)
    2. Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome. (PubMed id 12220626)1, 2, 9 Hoareau Alves K.... Jalinot P. (FEBS Lett. 2002)
    3. HIV-1 Vpr interacts with a human 34-kDa mov34 homologue, a cellular factor linked to the G2/M phase transition of the mammalian cell cycle. (PubMed id 9520381)1, 2, 9 Mahalingam S.... Weiner D.B. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    4. A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. (PubMed id 9535219)1, 2, 9 Seeger M.... Dubiel W. (FASEB J. 1998)
    5. COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3sigma. (PubMed id 21625211)1, 2 Choi H.H.... Lee M.H. (Oncogene 2011)
    6. Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. (PubMed id 18850735)1, 2 Fang L.... Huang L. (J. Proteome Res. 2008)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    9. Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome. (PubMed id 12628923)1, 2 Uhle S....Dubiel W. (EMBO J. 2003)
    10. The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. (PubMed id 12732143)1, 2 Groisman R.... Nakatani Y. (Cell 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10980 HGNC: 21749 AceView: COPS6 Ensembl:ENSG00000168090 euGenes: HUgn10980
    ECgene: COPS6 H-InvDB: COPS6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for COPS6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for COPS6 gene:
    Search GeneIP for patents involving COPS6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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