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Aliases for COPS6 Gene

Aliases for COPS6 Gene

  • COP9 Signalosome Subunit 6 2 3
  • CSN6 3 4 6
  • JAB1-Containing Signalosome Subunit 6 3 4
  • Vpr-Interacting Protein 3 4
  • Signalosome Subunit 6 3 4
  • SGN6 3 4
  • HVIP 3 4
  • COP9 Constitutive Photomorphogenic Homolog Subunit 6 (Arabidopsis) 2
  • COP9 Constitutive Photomorphogenic Homolog Subunit 6 3
  • COP9 Subunit 6 (MOV34 Homolog, 34 KD) 3
  • COP9 Signalosome Complex Subunit 6 3
  • COP9 Subunit 6 (MOV34 Homolog 2
  • MOV34 Homolog, 34 KD 3
  • H_NH0506M12.12 3
  • MOV34 Homolog 4
  • MOV34-34KD 3
  • 34 KD) 2

External Ids for COPS6 Gene

Summaries for COPS6 Gene

Entrez Gene Summary for COPS6 Gene

  • The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr. [provided by RefSeq, Jul 2008]

GeneCards Summary for COPS6 Gene

COPS6 (COP9 Signalosome Subunit 6) is a Protein Coding gene. Diseases associated with COPS6 include hiv-1. Among its related pathways are Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. An important paralog of this gene is PSMD7.

UniProtKB/Swiss-Prot for COPS6 Gene

  • Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity. Stabilizes RFWD2/COP1 through reducing RFWD2 auto-ubiquitination and decelerating RFWD2 turnover rate, hence regulates the ubiquitination of RFWD2 targets.

Gene Wiki entry for COPS6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COPS6 Gene

Genomics for COPS6 Gene

Genomic Location for COPS6 Gene

Start:
100,088,954 bp from pter
End:
100,092,200 bp from pter
Size:
3,247 bases
Orientation:
Plus strand

Genomic View for COPS6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COPS6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COPS6 Gene

Regulatory Elements for COPS6 Gene

Proteins for COPS6 Gene

  • Protein details for COPS6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L5N1-CSN6_HUMAN
    Recommended name:
    COP9 signalosome complex subunit 6
    Protein Accession:
    Q7L5N1
    Secondary Accessions:
    • A4D2A3
    • O15387

    Protein attributes for COPS6 Gene

    Size:
    327 amino acids
    Molecular mass:
    36163 Da
    Quaternary structure:
    • Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS2, COPS4, COPS5 and COPS7 (COPS7A or COPS7B). Interacts with the translation initiation factor EIF3S6. Interacts weakly with RBX1. Interacts with the HIV-1 protein Vpr. Directly interacts with RFWD2 and 14-3-3 protein sigma/SFN.
    SequenceCaution:
    • Sequence=AAD03469.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for COPS6 Gene

neXtProt entry for COPS6 Gene

Proteomics data for COPS6 Gene at MOPED

Post-translational modifications for COPS6 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys75, Lys102, Lys117, Lys153, Lys229, Lys236, Lys243, and Lys308

Other Protein References for COPS6 Gene

No data available for DME Specific Peptides for COPS6 Gene

Domains for COPS6 Gene

Protein Domains for COPS6 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

CSN6_HUMAN
Domain:
  • Contains 1 MPN (JAB/Mov34) domain.:
    • Q7L5N1
Family:
  • Belongs to the peptidase M67A family. CSN6 subfamily.:
    • Q7L5N1
genes like me logo Genes that share domains with COPS6: view

No data available for Gene Families for COPS6 Gene

Function for COPS6 Gene

Molecular function for COPS6 Gene

UniProtKB/Swiss-Prot Function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity. Stabilizes RFWD2/COP1 through reducing RFWD2 auto-ubiquitination and decelerating RFWD2 turnover rate, hence regulates the ubiquitination of RFWD2 targets.

Gene Ontology (GO) - Molecular Function for COPS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16169070
genes like me logo Genes that share ontologies with COPS6: view
genes like me logo Genes that share phenotypes with COPS6: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for COPS6 Gene

Localization for COPS6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COPS6 Gene

Nucleus. Cytoplasm. Note=The interaction with HIV-1 Vpr protein possibly leads its translocation to a perinuclear region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COPS6 Gene COMPARTMENTS Subcellular localization image for COPS6 gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 1
lysosome 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for COPS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0008180 COP9 signalosome IDA 18850735
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with COPS6: view

Pathways for COPS6 Gene

genes like me logo Genes that share pathways with COPS6: view

Pathways by source for COPS6 Gene

1 BioSystems pathway for COPS6 Gene

Gene Ontology (GO) - Biological Process for COPS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010388 cullin deneddylation IDA 19141280
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with COPS6: view

Transcripts for COPS6 Gene

Unigene Clusters for COPS6 Gene

COP9 signalosome subunit 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COPS6 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10
SP1: - - -
SP2: - - -
SP3: - - - -
SP4: - - - - - - -
SP5: - -
SP6: - - - - -
SP7: -
SP8:
SP9:

Relevant External Links for COPS6 Gene

GeneLoc Exon Structure for
COPS6
ECgene alternative splicing isoforms for
COPS6

Expression for COPS6 Gene

mRNA expression in normal human tissues for COPS6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COPS6 Gene

SOURCE GeneReport for Unigene cluster for COPS6 Gene Hs.15591

mRNA Expression by UniProt/SwissProt for COPS6 Gene

Q7L5N1-CSN6_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with COPS6: view

Orthologs for COPS6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for COPS6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COPS6 36
  • 99.29 (n)
  • 100 (a)
COPS6 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia COPS6 36
  • 93.6 (n)
  • 98.45 (a)
COPS6 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COPS6 36
  • 92.68 (n)
  • 99.36 (a)
COPS6 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cops6 36
  • 93.44 (n)
  • 99.05 (a)
Cops6 16
Cops6 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 96 (a)
OneToMany
-- 37
  • 96 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 23 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cops6 36
  • 92.72 (n)
  • 98.42 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 98 (a)
OneToMany
-- 37
  • 74 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.24180 36
tropical clawed frog
(Silurana tropicalis)
Amphibia cops6 36
  • 79.57 (n)
  • 92.93 (a)
Str.1495 36
zebrafish
(Danio rerio)
Actinopterygii cops6 36
  • 81.26 (n)
  • 91.92 (a)
COPS6 37
  • 66 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008156 36
  • 62.92 (n)
  • 59.81 (a)
fruit fly
(Drosophila melanogaster)
Insecta CSN6 36
  • 63.51 (n)
  • 62.16 (a)
CSN6 37
  • 57 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea csn-6 36
  • 48.24 (n)
  • 37.55 (a)
csn-6 37
  • 23 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPN8 37
  • 20 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons CSN6A 36
  • 51.59 (n)
  • 41.7 (a)
rice
(Oryza sativa)
Liliopsida Os08g0500000 36
  • 52.53 (n)
  • 41.08 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07019 36
  • 50.43 (n)
  • 38.86 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8166 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2251 37
  • 59 (a)
OneToOne
Species with no ortholog for COPS6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for COPS6 Gene

ENSEMBL:
Gene Tree for COPS6 (if available)
TreeFam:
Gene Tree for COPS6 (if available)

Paralogs for COPS6 Gene

Paralogs for COPS6 Gene

genes like me logo Genes that share paralogs with COPS6: view

Variants for COPS6 Gene

Sequence variations from dbSNP and Humsavar for COPS6 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1801417 -- 100,091,713(+) CATGA(A/G)CCAGT reference, missense
rs2272346 -- 100,091,199(-) CGGGA(G/T)GTGGC intron-variant
rs3823641 -- 100,090,597(+) GTGTG(C/T)GAGAT synonymous-codon, reference
rs4466319 -- 100,087,171(+) ACTCG(C/G)ATTAG upstream-variant-2KB
rs4729575 -- 100,089,250(+) GTGGG(C/G/T)CCCGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COPS6 Gene

Variant ID Type Subtype PubMed ID
nsv469687 CNV Loss 16826518
esv2734888 CNV Deletion 23290073
nsv510966 CNV Complex 20534489

Relevant External Links for COPS6 Gene

HapMap Linkage Disequilibrium report
COPS6

Disorders for COPS6 Gene

(1) MalaCards Diseases for COPS6 Gene

Search for COPS6 Gene in MalaCards »
genes like me logo Genes that share disorders with COPS6: view

No data available for UniProtKB/Swiss-Prot for COPS6 Gene

Publications for COPS6 Gene

  1. Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome. (PMID: 12220626) Hoareau Alves K. … Jalinot P. (FEBS Lett. 2002) 3 4 23
  2. Carboxyl terminus of hVIP/mov34 is critical for HIV-1-Vpr interaction and glucocorticoid-mediated signaling. (PMID: 12237292) Ramanathan M.P. … Weiner D.B. (J. Biol. Chem. 2002) 3 4 23
  3. HIV-1 Vpr interacts with a human 34-kDa mov34 homologue, a cellular factor linked to the G2/M phase transition of the mammalian cell cycle. (PMID: 9520381) Mahalingam S. … Weiner D.B. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 4 23
  4. A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. (PMID: 9535219) Seeger M. … Dubiel W. (FASEB J. 1998) 3 4 23
  5. Biochemical mechanism of HIV-I Vpr function. Specific interaction with a cellular protein. (PMID: 8195203) Zhao L.-J. … Narayan O. (J. Biol. Chem. 1994) 3 4

Products for COPS6 Gene

  • Addgene plasmids for COPS6

Sources for COPS6 Gene

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