COPS6 Gene
protein-coding GIFtS: 54
GCID: GC07P099686
|
|
COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)
| |
Aliases
for COPS6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| COP9 Constitutive Photomorphogenic Homolog Subunit 6 (Arabidopsis)1 2 | | JAB1-Containing Signalosome Subunit 62 3 | | CSN61 2 3 | | H_NH0506M12.122 | | MOV34-34KD1 2 | | COP9 Signalosome Complex Subunit 62 | | Signalosome Subunit 62 3 | | COP9 Subunit 6 (MOV34 Homolog, 34 KD)2 | | Vpr-Interacting Protein2 3 | | MOV34 Homolog, 34 KD2 | | SGN62 3 | | HVIP3 | | HVIP3 | | MOV34 Homolog3 |
Export aliases for COPS6 gene to outside databasesPrevious GC identifers: GC07P098221 GC07P099284 GC07P099298 GC07P099297 GC07P099331 GC07P099524 GC07P094322 |
Summaries
for COPS6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for COPS6:
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complexthat functions as an important regulator in multiple signaling pathways. The structure and function of COP9signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown tointeract with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This proteinbelongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle andlikely to be a cellular cofactor for HIV-1 accessory gene product Vpr. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CSN6_HUMAN, Q7L5N1Function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmentalprocesses. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating thedeneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity ofSCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN,IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependentphosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has someglucocorticoid receptor-responsive activity. Stabilizes RFWD2/COP1 through reducing RFWD2 auto-ubiquitination anddecelerating RFWD2 turnover rate, hence regulates the ubiquitination of RFWD2 targets
Gene Wiki entry for COPS6
|
Genomic Views
for COPS6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the COPS6 gene promoter:
Pax-6 Arnt NF-AT NF-AT4 POU2F1 NF-AT2 POU2F1a SEF-1 (1) NF-AT3 NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for COPS6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COPS6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q22.1 Ensembl cytogenetic band: 7q22.1 HGNC cytogenetic band: 7q22.1COPS6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P099686: view genomic region
(about GC identifiers)
Start:
|
99,686,577 bp from pter |
End:
|
99,689,823 bp from pter |
Size:
|
3,247 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 99,046,703-99,049,943 |
|
Proteins
for COPS6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CSN6_HUMAN, Q7L5N1 (See
protein sequence)Recommended Name: COP9 signalosome complex subunit 6 Size: 327 amino acids; 36163 Da
Subunit: Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A orCOPS7B) and COPS8. In the complex, it probably interacts directly with COPS2, COPS4, COPS5 and COPS7 (COPS7A orCOPS7B). Interacts with the translation initiation factor EIF3S6. Interacts weakly with RBX1. Interacts with the HIV-1protein Vpr. Directly interacts with RFWD2 and 14-3-3 protein sigma/SFN
Subcellular location: Nucleus. Cytoplasm. Note=The interaction with HIV-1 Vpr protein possibly leads its translocationto a perinuclear region
Caution: Although related to the peptidase M67A family, it lacks the JAMM motif that probably constitutes the catalyticcenter and therefore it probably does not have a protease activity
Sequence caution: Sequence=AAD03469.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A4D2A3 O15387Explore the universe of human proteins at neXtProt for COPS6: NX_Q7L5N1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7L5N1
COPS6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006824.2
ENSEMBL proteins: ENSP00000304102 ENSP00000388865 ENSP00000400617 ENSP00000413702
Human Recombinant Protein Products for COPS6:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
COPS6 for ontologies About GeneDecksing
COPS6 Antibody Products:
Assay Products for COPS6: |
Protein
Domains /
Families
for COPS6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
COPS6 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q7L5N1ProtoNet protein and cluster: Q7L5N1 1 Blocks protein family: IPB000555 Mov34 family
UniProtKB/Swiss-Prot: CSN6_HUMAN, Q7L5N1Similarity: Belongs to the peptidase M67A family. CSN6 subfamilySimilarity: Contains 1 MPN (JAB/Mov34) domain |
Function
for COPS6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: CSN6_HUMAN, Q7L5N1Function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmentalprocesses. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating thedeneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity ofSCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN,IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependentphosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has someglucocorticoid receptor-responsive activity. Stabilizes RFWD2/COP1 through reducing RFWD2 auto-ubiquitination anddecelerating RFWD2 turnover rate, hence regulates the ubiquitination of RFWD2 targets Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- |
COPS6 for ontologies About GeneDecksing
Phenotypes:
5 GenomeRNAi human phenotypes for COPS6:
7 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Cops6):
COPS6 for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COPS6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COPS6
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: COPS6 (NM_006833) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COPS6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COPS6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPS6 |
|
Pathways & Interactions
for COPS6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | |
1  BioSystems Pathway for COPS6
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for COPS6
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/738 Interacting proteins for COPS6 (Q7L5N11, 2, 3 ENSP000003041024) via UniProtKB, MINT, STRING, and/or I2D (see all 738)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| BTBD2 | Q9BX701, 2, 3, ENSP000002556084 | EBI-486838,EBI-710091 MINT-65386 I2D:
score=5 STRING: ENSP00000255608 | | SMN1 | Q166372, 3 | MINT-7945693 MINT-64290 MINT-8270992 I2D:
score=5 | | SMN2 | Q166372, 3 | MINT-7945693 MINT-64290 MINT-8270992 I2D:
score=5 | | PBX2 | P404252, 3, ENSP000003641904 | MINT-62745 MINT-62669 MINT-62571 I2D:
score=4 STRING: ENSP00000364190 | | FAU | P355442, 3, ENSP000002792594 | I2D:
score=2 MINT-63691 I2D:
score=3 STRING: ENSP00000279259 |
About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
COPS6 for ontologies About GeneDecksing
|
Drugs & Compounds
for COPS6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for COPS6
Search CenterWatch for drugs/clinical trials and news about COPS6 / CSN6
|
Transcripts
for COPS6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for COPS6 gene: NM_006833.4 Unigene Cluster for COPS6: COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis) Hs.15591 [show with all ESTs]Unigene Representative Sequence: BM54204010 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000303904(uc003usu.3) ENST00000465027(uc011kjf.1) ENST00000419210
ENST00000418625 ENST00000472107 ENST00000468499 ENST00000496358 ENST00000474823
ENST00000426712 ENST00000483891
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COPS6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COPS6
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: COPS6 (NM_006833) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COPS6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COPS6 |
Additional cDNA sequence: AK295237.1 AK312024.1 BC002520.2 U70735.1 14 DOTS entries: DT.95170955 DT.95315984 DT.453098 DT.100815364 DT.95170972 DT.121065250 DT.100815360 DT.121065372 DT.95170970 DT.121065332 DT.100815361 DT.91960947 DT.95170966 DT.95170967 24/470 AceView cDNA sequences (see all 470): BQ276375 BM800960 BQ425507 NM_006833 BG825063 BG740703 AI369201 BG751747 BX107732 BQ420654 BI256726 BQ778077 BX458413 BC002520 BU507359 BE296599 AI359633 BG105952 AA960883 BG324664 BE794931 CR593453 AA947240 BU154079
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for COPS6 (see all 9) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 |
|---|
|
| SP1: | | | | | | | | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | - | | - | | - | | | | - | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for COPS6
|
Expression
for COPS6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| COPS6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACCAGTTTG
About this image
See COPS6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for COPS6
SOURCE GeneReport for Unigene cluster: Hs.15591
UniProtKB/Swiss-Prot: CSN6_HUMAN, Q7L5N1Tissue specificity: Widely expressed
SABiosciences Expression via Pathway-Focused PCR Array including COPS6: | HIV Host Response in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COPS6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat COPS6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COPS6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COPS6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPS6 |
Orthologs
for COPS6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for COPS6 gene from 7/27 species (see all 27) About this table
ENSEMBL Gene Tree for COPS6 (if available)
TreeFam Gene Tree for COPS6 (if available) |
Paralogs
for COPS6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for COPS6 gene
- PSMD72 EIF3F2
COPS6 for paralogs About GeneDecksing
|
Genomic Variants
for COPS6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for COPS6 (99686577 - 99689823 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for COPS6
1 CNV: 2104 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COPS6 |
|
Disorders
/ Diseases
for COPS6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
COPS6 for disorders About GeneDecksing
OMIM gene information: 614729
OMIM disorders: --
8  diseases for COPS6: About MalaCardsmicrophthalmia syndromic 6 hereditary renal cell carcinoma renal cell carcinoma microphthalmia
huntington's disease kidney cancer carcinoma immunodeficiency
Export disorders for COPS6 gene to outside databases
|
Publications
for COPS6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for COPS6 gene, integrated from 9 sources (see all 73):
(articles sorted by number of sources associating them with COPS6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Carboxyl terminus of hVIP/mov34 is critical for HIV-1-Vpr interaction and glucocorticoid-mediated signaling. (PubMed id 12237292)1, 2, 9 Ramanathan M.P.... Weiner D.B. (2002)
- Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome. (PubMed id 12220626)1, 2, 9 Hoareau Alves K.... Jalinot P. (2002)
- HIV-1 Vpr interacts with a human 34-kDa mov34 homologue, a cellular factor linked to the G2/M phase transition of the mammalian cell cycle. (PubMed id 9520381)1, 2, 9 Mahalingam S.... Weiner D.B. (1998)
- A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. (PubMed id 9535219)1, 2, 9 Seeger M....Dubiel W. (1998)
- Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. (PubMed id 18850735)1, 2 Fang L.... Huang L. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
- Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome. (PubMed id 12628923)1, 2 Uhle S....Dubiel W. (2003)
- The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. (PubMed id 12732143)1, 2 Groisman R.... Nakatani Y. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
|
External Searches for COPS6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing COPS6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing COPS6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing COPS6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for COPS6 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for COPS6 gene:
Search GeneIP for patents involving COPS6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for COPS6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
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| | |  | OriGene Antibodies for COPS6 | | OriGene shRNA RFP for COPS6 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COPS6 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COPS6 | | | OriGene Protein Over-expression Lysate for COPS6 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for COPS6 | | OriGene 3'-UTR Clone for COPS6 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COPS6 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COPS6 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for COPS6 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for COPS6 | | OriGene Custom Protein Services for COPS6 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat COPS6 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COPS6 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COPS6 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COPS6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COPS6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COPS6 |
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| | | | Search Tocris compounds for COPS6 |
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 | | | COPS6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPS6 |
|  |  |  |  | | | | ThermoFisher Antibodies for COPS6 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COPS6 |
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