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Aliases for COPS5 Gene

Aliases for COPS5 Gene

  • COP9 Signalosome Subunit 5 2 3 5
  • Jun Activation Domain-Binding Protein 1 3 4
  • Signalosome Subunit 5 3 4
  • CSN5 3 4
  • JAB1 3 4
  • SGN5 3 4
  • COP9 (Constitutive Photomorphogenic, Arabidopsis, Homolog) Subunit 5 2
  • COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) 2
  • COP9 Constitutive Photomorphogenic Homolog Subunit 5 3
  • Testis Secretory Sperm-Binding Protein Li 231m 3
  • COP9 Signalosome Complex Subunit 5 3
  • 38 KDa Mov34 Homolog 3
  • EC 3.4.-.- 4
  • MOV-34 3

External Ids for COPS5 Gene

Previous GeneCards Identifiers for COPS5 Gene

  • GC08M067894
  • GC08M067678
  • GC08M068005
  • GC08M068117
  • GC08M063447
  • GC08M067955

Summaries for COPS5 Gene

Entrez Gene Summary for COPS5 Gene

  • The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]

GeneCards Summary for COPS5 Gene

COPS5 (COP9 Signalosome Subunit 5) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Clathrin-mediated endocytosis. GO annotations related to this gene include transcription coactivator activity and thiol-dependent ubiquitin-specific protease activity.

UniProtKB/Swiss-Prot for COPS5 Gene

  • Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2.

Gene Wiki entry for COPS5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COPS5 Gene

Genomics for COPS5 Gene

Regulatory Elements for COPS5 Gene

Enhancers for COPS5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G066774 1.3 ENCODE dbSUPER 10 +308.5 308503 2.2 PKNOX1 FOXA2 CREB3L1 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 ZNF143 CSPP1 COPS5 C8orf44 PTTG3P GC08M066750
GH08G066678 1.2 Ensembl ENCODE dbSUPER 9.7 +403.9 403904 2.6 JUN FOSL1 ZNF316 POLR2A FOS NFE2 MAFK NFE2L2 CEBPB MAFG CSPP1 COPS5 C8orf44 C8orf44-SGK3 SGK3
GH08G067028 1 ENCODE 11.5 +54.8 54809 1.9 PKNOX1 ATF1 CREB3L1 ARID4B SIN3A FEZF1 BRCA1 GLIS2 ZHX2 REST PPP1R42 CSPP1 COPS5 SNHG6 SNORD87 LOC105375885
GH08G066917 1.1 Ensembl ENCODE 10.2 +164.5 164469 4.2 AGO1 BMI1 ZBTB40 RAD21 RFX5 YY1 ZNF143 RELB IKZF2 BCLAF1 CSPP1 COPS5 PPP1R42 TCF24 GC08M066923 MCMDC2
GH08G066961 1.1 Ensembl ENCODE 10.1 +121.6 121552 2.4 PKNOX1 ZBTB7B RAD21 GLIS2 ZNF366 SCRT2 SP3 CBFB KLF16 ZNF341 SNORD87 SNHG6 PPP1R42 CSPP1 COPS5 TCF24
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around COPS5 on UCSC Golden Path with GeneCards custom track

Genomic Location for COPS5 Gene

Chromosome:
8
Start:
67,043,079 bp from pter
End:
67,083,783 bp from pter
Size:
40,705 bases
Orientation:
Minus strand

Genomic View for COPS5 Gene

Genes around COPS5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COPS5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COPS5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COPS5 Gene

Proteins for COPS5 Gene

  • Protein details for COPS5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92905-CSN5_HUMAN
    Recommended name:
    COP9 signalosome complex subunit 5
    Protein Accession:
    Q92905
    Secondary Accessions:
    • O15386
    • Q6AW95
    • Q86WQ4
    • Q9BQ17

    Protein attributes for COPS5 Gene

    Size:
    334 amino acids
    Molecular mass:
    37579 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    • Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 isoform 1 (PubMed:26456823). In the complex, it probably interacts directly with COPS1, COPS2, COPS4, COPS6 and COPS7 (COPS7A or COPS7B) and COPS9 isoform 1 (PubMed:26456823). Interacts with COPS9 isoform 2 (PubMed:23776465). The CSN complex interacts with the BRISC complex. Also exists as monomeric form. Interacts with TP53, MIF, JUN, UCHL1, NCOA1, HIF1A, CDKN1B, BCL3, GFER, PGR, LHCGR, SMAD4, SMAD7, ID1, ID3, ITGB2 and TOP2A. Part of a complex consisting of RANBP9, Ran, DYRK1B and COPS5. Interacts with IFIT3. Interacts with BRSK2. Interacts with ZDHHC16 (PubMed:17123647). Interacts with MINDY3 (PubMed:21499297).
    Miscellaneous:
    • The CSN complex is associated with some Lys-63-specific deubiquitination. Such activity is however not mediated by the core CSN complex but by the BRCC3/BRCC36 component of the BRISC complex.
    SequenceCaution:
    • Sequence=AAL82571.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for COPS5 Gene

neXtProt entry for COPS5 Gene

Post-translational modifications for COPS5 Gene

  • Ubiquitination at isoforms=11, Lys47, Lys56, isoforms=125, isoforms=180, and isoforms=236
  • Modification sites at PhosphoSitePlus

Other Protein References for COPS5 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for COPS5 (COPS5)

No data available for DME Specific Peptides for COPS5 Gene

Domains & Families for COPS5 Gene

Gene Families for COPS5 Gene

Protein Domains for COPS5 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for COPS5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92905

UniProtKB/Swiss-Prot:

CSN5_HUMAN :
  • The JAMM motif is essential for the protease activity of the CSN complex resulting in deneddylation of cullins. It constitutes the catalytic center of the complex (By similarity).
  • Belongs to the peptidase M67A family. CSN5 subfamily.
Domain:
  • The JAMM motif is essential for the protease activity of the CSN complex resulting in deneddylation of cullins. It constitutes the catalytic center of the complex (By similarity).
Family:
  • Belongs to the peptidase M67A family. CSN5 subfamily.
genes like me logo Genes that share domains with COPS5: view

Function for COPS5 Gene

Molecular function for COPS5 Gene

UniProtKB/Swiss-Prot Function:
Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2.

Enzyme Numbers (IUBMB) for COPS5 Gene

Gene Ontology (GO) - Molecular Function for COPS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity TAS 8837781
GO:0003743 translation initiation factor activity TAS 9341143
GO:0004843 thiol-dependent ubiquitin-specific protease activity IDA 19246649
GO:0005515 protein binding IPI 12082530
GO:0008233 peptidase activity IEA --
genes like me logo Genes that share ontologies with COPS5: view
genes like me logo Genes that share phenotypes with COPS5: view

Animal Models for COPS5 Gene

MGI Knock Outs for COPS5:

Animal Model Products

miRNA for COPS5 Gene

miRTarBase miRNAs that target COPS5

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for COPS5

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for COPS5 Gene

Localization for COPS5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COPS5 Gene

Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Note=Nuclear localization is diminished in the presence of IFIT3.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for COPS5 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for COPS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 17050680
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA,IEA 17050680
GO:0005829 cytosol TAS --
GO:0005852 eukaryotic translation initiation factor 3 complex TAS 9341143
genes like me logo Genes that share ontologies with COPS5: view

Pathways & Interactions for COPS5 Gene

genes like me logo Genes that share pathways with COPS5: view

Pathways by source for COPS5 Gene

SIGNOR curated interactions for COPS5 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for COPS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000338 protein deneddylation IMP 19214193
GO:0000715 nucleotide-excision repair, DNA damage recognition TAS --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0006366 transcription from RNA polymerase II promoter TAS 8837781
GO:0006412 translation TAS 9341143
genes like me logo Genes that share ontologies with COPS5: view

Drugs & Compounds for COPS5 Gene

(1) Drugs for COPS5 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for COPS5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with COPS5: view

Transcripts for COPS5 Gene

Unigene Clusters for COPS5 Gene

COP9 signalosome subunit 5:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for COPS5

Alternative Splicing Database (ASD) splice patterns (SP) for COPS5 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^
SP1: - - - - - - - -
SP2: - - -
SP3: - - - - - - -
SP4:
SP5: - - - - - - - -
SP6:
SP7: - - - - - - - - - - - - - - - -
SP8: - - - - - - -
SP9: - - - - - -
SP10:
SP11: - - - - - - - - -
SP12:
SP13: - -
SP14: - - - -
SP15: - - - - -
SP16: - - - -
SP17:

ExUns: 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13a · 13b · 13c
SP1: - - - - -
SP2: - - - - -
SP3:
SP4: - - - - -
SP5:
SP6: - - - -
SP7:
SP8:
SP9:
SP10: - -
SP11:
SP12: -
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for COPS5 Gene

GeneLoc Exon Structure for
COPS5
ECgene alternative splicing isoforms for
COPS5

Expression for COPS5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for COPS5 Gene

Protein differential expression in normal tissues from HIPED for COPS5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for COPS5 Gene



Protein tissue co-expression partners for COPS5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of COPS5 Gene:

COPS5

SOURCE GeneReport for Unigene cluster for COPS5 Gene:

Hs.491912

Evidence on tissue expression from TISSUES for COPS5 Gene

  • Nervous system(4.9)
  • Liver(4.5)
  • Muscle(4.5)
  • Eye(4.3)
  • Lung(3.6)
  • Kidney(2.8)
  • Intestine(2.7)
  • Adrenal gland(2.5)
  • Bone marrow(2.5)
  • Gall bladder(2.5)
  • Pancreas(2.5)
  • Skin(2.5)
  • Stomach(2.5)
  • Thyroid gland(2.5)
  • Lymph node(2.3)
  • Heart(2.2)
genes like me logo Genes that share expression patterns with COPS5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for COPS5 Gene

Orthologs for COPS5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for COPS5 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia COPS5 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia COPS5 34 35
  • 99.8 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia COPS5 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COPS5 34 35
  • 95.01 (n)
cow
(Bos Taurus)
Mammalia COPS5 34 35
  • 94.41 (n)
mouse
(Mus musculus)
Mammalia Cops5 34 16 35
  • 91.82 (n)
rat
(Rattus norvegicus)
Mammalia Cops5 34
  • 91.32 (n)
chicken
(Gallus gallus)
Aves COPS5 34 35
  • 85.19 (n)
lizard
(Anolis carolinensis)
Reptilia COPS5 35
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cops5 34
  • 82.63 (n)
MGC76063 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.3139 34
zebrafish
(Danio rerio)
Actinopterygii cops5 34 35
  • 81.17 (n)
zgc73130 34
fruit fly
(Drosophila melanogaster)
Insecta CSN5 36 34 35
  • 67.08 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002880 34
  • 64.92 (n)
worm
(Caenorhabditis elegans)
Secernentea csn-5 34 35
  • 58.41 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RRI1 35 37
  • 21 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons CSN5B 34
  • 64.37 (n)
soybean
(Glycine max)
eudicotyledons Gma.2729 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7479 34
rice
(Oryza sativa)
Liliopsida Os04g0654700 34
  • 63.85 (n)
Os.2223 34
barley
(Hordeum vulgare)
Liliopsida Hv.8820 34
wheat
(Triticum aestivum)
Liliopsida Ta.29627 34
corn
(Zea mays)
Liliopsida Zm.3995 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 79 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU00467 34
  • 55.78 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4559 34
Species where no ortholog for COPS5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for COPS5 Gene

ENSEMBL:
Gene Tree for COPS5 (if available)
TreeFam:
Gene Tree for COPS5 (if available)

Paralogs for COPS5 Gene

(1) SIMAP similar genes for COPS5 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for COPS5 Gene

genes like me logo Genes that share paralogs with COPS5: view

No data available for Paralogs for COPS5 Gene

Variants for COPS5 Gene

Sequence variations from dbSNP and Humsavar for COPS5 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000234446 -- 67,044,191(+) ATCTG(C/T)GCCAC intron-variant
rs1000248986 -- 67,045,344(+) AGTTA(A/C)TTGGG intron-variant
rs1000577943 -- 67,047,281(+) AAAAT(A/G)CTACC intron-variant
rs1000636883 -- 67,046,922(+) GAAGT(-/AAAC)AAACA intron-variant
rs1000916301 -- 67,050,191(+) AGAGA(C/T)GGGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COPS5 Gene

Variant ID Type Subtype PubMed ID
esv3617494 CNV gain 21293372
esv3891407 CNV gain 25118596

Variation tolerance for COPS5 Gene

Residual Variation Intolerance Score: 32.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COPS5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
COPS5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COPS5 Gene

Disorders for COPS5 Gene

Relevant External Links for COPS5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COPS5

No disorders were found for COPS5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COPS5 Gene

Publications for COPS5 Gene

  1. RIG-G as a key mediator of the antiproliferative activity of interferon-related pathways through enhancing p21 and p27 proteins. (PMID: 17050680) Xiao S. … Tong J.H. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 4 22 64
  2. Intracrine hepatopoietin potentiates AP-1 activity through JAB1 independent of MAPK pathway. (PMID: 11709497) Lu C. … He F. (FASEB J. 2002) 3 4 22 64
  3. Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation. (PMID: 11818334) Wan M. … Cao X. (EMBO Rep. 2002) 3 4 22 64
  4. Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity. (PMID: 10766246) Bianchi E. … Pardi R. (Nature 2000) 3 4 22 64
  5. Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1. (PMID: 11089976) Kleemann R. … Bernhagen J. (Nature 2000) 3 4 22 64

Products for COPS5 Gene

  • Addgene plasmids for COPS5

Sources for COPS5 Gene

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