COPS5 Gene
protein-coding GIFtS: 61
GCID: GC08M068005
|
|
COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)(Previous names: COP9 (constitutive photomorphogenic, Arabidopsis, homolog)...)
| |
Aliases
for COPS5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis)1 2 | | Signalosome Subunit 52 3 | | CSN51 2 3 | | COP9 (Constitutive Photomorphogenic, Arabidopsis, Homolog) Subunit 51 | | JAB11 2 3 | | 38 KDa Mov34 Homolog2 | | SGN51 2 3 | | COP9 Signalosome Complex Subunit 52 | | MOV-341 2 | | EC 3.4.-.-3 | | Jun Activation Domain-Binding Protein 12 3 | | |
Export aliases for COPS5 gene to outside databasesPrevious GC identifers: GC08M067077 GC08M067894 GC08M067678 GC08M068117 GC08M063447 |
Summaries
for COPS5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for COPS5:
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complexthat functions as an important regulator in multiple signaling pathways. The structure and function of COP9signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown tointeract with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein isreported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to bean coactivator that increases the specificity of JUN/AP1 transcription factors. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CSN5_HUMAN, Q92905Function: Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular anddevelopmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway bymediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ublligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation ofp53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases.CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Inthe complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however hasno metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with alarge number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes theproteasomal degradation of BRSK2
Gene Wiki entry for COPS5 (COP9 constitutive photomorphogenic homolog subunit 5)
|
Genomic Views
for COPS5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008183.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the COPS5 gene promoter:
HFH-3 Pax-2 CUTL1 Pax-2a YY1 FOXI1 MEF-2A NRF-2 Pax-2b aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for COPS5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COPS5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q13.1 Ensembl cytogenetic band: 8q13.1 HGNC cytogenetic band: 8q13.1COPS5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M068005: view genomic region
(about GC identifiers)
Start:
|
67,955,314 bp from pter |
End:
|
67,996,018 bp from pter |
Size:
|
40,705 bases |
Orientation:
|
minus strand |
|
Proteins
for COPS5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CSN5_HUMAN, Q92905 (See
protein sequence)Recommended Name: COP9 signalosome complex subunit 5 Size: 334 amino acids; 37579 Da
Cofactor: Divalent metal ions (By similarity)
Subunit: Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A orCOPS7B) and COPS8. In the complex, it probably interacts directly with COPS1, COPS2, COPS4, COPS6 and COPS7 (COPS7A orCOPS7B). The CSN complex interacts with the BRISC complex. Also exists as monomeric form. Interacts with TP53, MIF,JUN, UCHL1, NCOA1, HIF1A, CDKN1B, BCL3, GFER, PGR, LHCGR, SMAD4, SMAD7, ID1, ID3, ITGB2 and TOP2A. Part of a complexconsisting of RANBP9, Ran, DYRK1B and COPS5. Interacts with IFIT3. Interacts with BRSK2
Subcellular location: Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Note=Nuclear localization is diminished in thepresence of IFIT3
Miscellaneous: The CSN complex is associated with some 'Lys-63'-specific deubiquitination. Such activity is however notmediated by the core CSN complex but by the BRCC3/BRCC36 component of the BRISC complex
Sequence caution: Sequence=AAL82571.1; Type=Erroneous initiation;
1 PDB 3D structure from  and Proteopedia  for COPS5:4F7O (3D)
Secondary accessions: O15386 Q6AW95 Q86WQ4 Q9BQ17Explore the universe of human proteins at neXtProt for COPS5: NX_Q92905
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q92905
COPS5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006828.2
ENSEMBL proteins: ENSP00000350512 ENSP00000429774 ENSP00000427869 ENSP00000427997 ENSP00000428586 ENSP00000428124
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
COPS5 for ontologies About GeneDecksing
COPS5 Antibody Products:
Assay Products for COPS5: |
Protein
Domains /
Families
for COPS5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
COPS5 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q92905ProtoNet protein and cluster: Q92905 1 Blocks protein family: IPB000555 Mov34 family
UniProtKB/Swiss-Prot: CSN5_HUMAN, Q92905Domain: The JAMM motif is essential for the protease activity of the CSN complex resulting in deneddylation of cullins.It constitutes the catalytic center of the complex (By similarity)Similarity: Belongs to the peptidase M67A family. CSN5 subfamilySimilarity: Contains 1 MPN (JAB/Mov34) domain |
Function
for COPS5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CSN5_HUMAN, Q92905Function: Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular anddevelopmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway bymediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ublligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation ofp53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases.CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Inthe complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however hasno metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with alarge number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes theproteasomal degradation of BRSK2Enzyme Number (IUBMB): EC 3.4.-.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COPS5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COPS5 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: COPS5 (NM_006837) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COPS5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COPS5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPS5 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
COPS5 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for COPS5:
Animal Models:
Mouse knock-outs for COPS5: Cops5tm1Jka Cops5tm1Fxc
8 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Cops5):
COPS5 for phenotypes About GeneDecksing
|
Pathways & Interactions
for COPS5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Immune response_MIF-JAB1 signaling | | | 2 | Protein Stability | | | 3 | Cell Cycle / Checkpoint Control | | | 4 | HIF1Alpha Pathway | | | 5 | TGF-beta Receptor Signaling Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for COPS5
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for COPS5
2 
Cell Signaling Technology (CST) Pathways for COPS5
1  GeneGo (Thomson Reuters) Pathway for COPS5
3  BioSystems Pathways for COPS5
COPS5 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for COPS5
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/1010 Interacting proteins for COPS5 (Q929051, 2, 3 ENSP000003505124) via UniProtKB, MINT, STRING, and/or I2D (see all 1010)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| GFER | P557892, 3, ENSP000002481144 | MINT-50626 MINT-50637 MINT-50636 MINT-50625 I2D:
score=3 STRING: ENSP00000248114 | | CARD11 | Q9BXL72, 3, ENSP000003801504 | MINT-7228563 MINT-7228732 I2D:
score=3 STRING: ENSP00000380150 | | CUL1 | Q136162, 3, ENSP000003268044 | MINT-7945693 MINT-7947479 I2D:
score=3 STRING: ENSP00000326804 | | COPS6 | Q7L5N12, 3, ENSP000003041024 | MINT-7945693 MINT-7230300 I2D:
score=11 STRING: ENSP00000304102 | | HSP90AB1 | P082382, 3, ENSP000003258754 | MINT-7945693 MINT-7947479 I2D:
score=1 STRING: ENSP00000325875 |
About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table
COPS5 for ontologies About GeneDecksing
|
Drugs & Compounds
for COPS5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
COPS5 for compounds About GeneDecksing
 Browse Tocris compounds for COPS5
2 Novoseek chemical compound relationships for COPS5 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| chi 2 |
20.1 |
2 |
15154004 (1), 15887118 (1) |
| serine |
0 |
1 |
12119282 (1) |
Search CenterWatch for drugs/clinical trials and news about COPS5 / CSN5
|
Transcripts
for COPS5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for COPS5 gene: NM_006837.2 Unigene Cluster for COPS5: COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) Hs.491912 [show with all ESTs]Unigene Representative Sequence: AB20913413 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000523086 ENST00000357849(uc003xxe.3 uc010lyv.1) ENST00000521509(uc003xxd.3 uc003xxf.3)
ENST00000517736 ENST00000521386 ENST00000518374 ENST00000523890(uc010lyu.1)
ENST00000518747 ENST00000517793 ENST00000517406 ENST00000519963 ENST00000519057
ENST00000518768
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COPS5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COPS5 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: COPS5 (NM_006837) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COPS5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COPS5 |
Additional cDNA sequence: AB209134.1 AK056967.1 AK128519.1 AK310434.1 AK311071.1 BC001187.1 BC001859.2 BC007272.1 BX648542.1 CR541678.1 U65928.1 U70734.1 19 DOTS entries: DT.445035 DT.100811298 DT.91922156 DT.95370546 DT.75193043 DT.100745730 DT.120640472 DT.120640468 DT.92452030 DT.95370541 DT.97854658 DT.100811295 DT.120640614 DT.91740752 DT.120640486 DT.95370549 DT.86855098 DT.95370540 DT.95370548 24/546 AceView cDNA sequences (see all 546): CR604403 AA740518 BU521615 BM974176 BM809985 BM667090 CN484313 BE266010 BM562772 BM908566 AI581328 BM556471 BC007272 BQ712515 BE797047 BG683522 BX098163 CB853308 BE278105 BM876402 CF128426 BU856447 AA461527 CA433281
GeneLoc Exon Structure
5/17 Alternative Splicing Database (ASD) splice patterns (SP) for COPS5 (see all 17) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | · | 2f | · | 2g | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | |
| ExUns: | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | · | 12c | ^ | 13a | · | 13b | · | 13c |
|---|
|
| SP1: | | | - | | - | | - | | - | | | | - | | | | | | | | |
| SP2: | | | - | | - | | - | | - | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | - | | - | | - | | - | | | | - | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for COPS5
|
Expression
for COPS5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| COPS5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATTGATGTC
About this image
See COPS5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for COPS5
SOURCE GeneReport for Unigene cluster: Hs.491912
SABiosciences Expression via Pathway-Focused PCR Array including COPS5:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COPS5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat COPS5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COPS5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COPS5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPS5 |
Orthologs
for COPS5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for COPS5 gene from 9/36 species (see all 36) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Cops51 , 5 |
COP9 (constitutive photomorphogenic) homolog, subunit more1, 5 |
91.82(n)1
99.4(a)1 |
|
1 (2.29 cM)5
267541 NM_013715.11 NP_038743.11
100246025 |
chicken
(Gallus gallus) |
Aves |
COPS51 |
COP9 constitutive photomorphogenic homolog subunit more |
85.34(n)
98.8(a) |
|
426579 NM_001039311.1 NP_001034400.1 |
lizard
(Anolis carolinensis) |
Reptilia |
COPS56 |
-- |
99(a) |
1 ↔ 1 |
4(31092703-31101470) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.31392 |
Xenopus laevis transcribed sequence with strong similarity more |
82.39(n) |
|
CD253707.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc731302 |
hypothetical protein MGC73130 |
81.88(n) |
|
393698 BC059493.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CSN51 , 3 |
axonogenesis3
COP9 complex homolog subunit 51 |
73(a)3
67.08(n)1
75.85(a)1 |
|
420001 NM_058094.41 NP_477442.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
csn-51 |
Protein CSN-5 |
58.41(n)
59.81(a) |
|
177342 NM_068440.3 NP_500841.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
CSN5B1 |
COP9 signalosome complex subunit 5a |
64.37(n)
68.26(a) |
|
843463 NM_105792.1 NP_177279.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.22232 |
Oryza sativa subsp. indica jab1 protein (jab1) mRNA, more |
74.38(n) |
|
AF072849.1 |
ENSEMBL Gene Tree for COPS5 (if available)
TreeFam Gene Tree for COPS5 (if available) |
Paralogs
for COPS5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for COPS5 gene
1 SIMAP similar gene for COPS5 using alignment to 6 protein entries: CSN5_HUMAN (see all proteins):PSMD14
COPS5 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for COPS5
PGOHUM00000239598 PGOHUM00000243296
|
Genomic Variants
for COPS5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for COPS5 (67955314 - 67996018 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for COPS5: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COPS5 |
|
Disorders
/ Diseases
for COPS5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
COPS5 for disorders About GeneDecksing
OMIM gene information: 604850
OMIM disorders: --
20/43  diseases for COPS5 (see all 43): About MalaCardswest nile virus anaplastic large cell lymphoma non-hodgkin lymphoma squamous cell carcinoma
b-cell lymphomas laryngeal squamous cell carcinoma oral squamous cell carcinoma thyroid medullary carcinoma
embryonal rhabdomyosarcoma benign tumors hodgkin's lymphoma ductal carcinoma in situ
papillary thyroid carcinoma rheumatoid arthritis chronic myeloid leukemia intrahepatic cholangiocarcinoma
carcinoma pituitary adenoma myeloid leukemia rhabdomyosarcoma
10/17 Novoseek disease relationships for COPS5 gene (see all 17) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tumors |
40.2 |
71 |
11751512 (5), 19461157 (5), 14654548 (3), 12631617 (3) (see all 29) |
| cancer |
35.8 |
24 |
17027978 (2), 19461157 (2), 17914096 (2), 17203996 (2) (see all 11) |
| hepatocellular carcinoma |
27.6 |
5 |
19080643 (2), 18346358 (1), 17651785 (1), 16000397 (1) |
| benign tumor |
25.8 |
2 |
11751512 (1), 19139918 (1) |
| pancreatic cancer |
25.1 |
12 |
17027978 (3), 19395473 (2), 16951171 (2), 14719054 (2) |
| ovarian carcinoma |
24.3 |
2 |
19139918 (1), 16525656 (1) |
| lymphoma |
21.9 |
10 |
14666612 (5), 18246793 (3), 12631617 (1), 18285702 (1) |
| breast cancer |
19.9 |
23 |
14654548 (4), 18534028 (4), 18246048 (3), 17914096 (3) (see all 6) |
| breast carcinoma |
12.7 |
8 |
12782606 (3), 14654548 (2), 15217497 (1) |
| adenoma |
8.75 |
1 |
12860294 (1) |
Export disorders for COPS5 gene to outside databases
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Publications
for COPS5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for COPS5 gene, integrated from 9 sources (see all 207):
(articles sorted by number of sources associating them with COPS5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly. (PubMed id 9341143)1, 2, 3 Asano K.... Hershey J.W.B. (1997)
- A new group of conserved coactivators that increase the specificity of AP-1 transcription factors. (PubMed id 8837781)1, 2, 3 Claret F.-X.... Karin M. (1996)
- Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1. (PubMed id 11089976)1, 2, 9 Kleemann R.... Bernhagen J. (2000)
- Intracrine hepatopoietin potentiates AP-1 activity through JAB1 independent of MAPK pathway. (PubMed id 11709497)1, 2, 9 Lu C.... He F. (2002)
- Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation. (PubMed id 11818334)1, 2, 9 Wan M.... Cao X. (2002)
- Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity. (PubMed id 10766246)1, 2, 9 Bianchi E.... Pardi R. (2000)
- RIG-G as a key mediator of the antiproliferative activity of interferon-related pathways through enhancing p21 and p27 proteins. (PubMed id 17050680)1, 2, 9 Xiao S....Tong J.H. (2006)
- A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. (PubMed id 9535219)1, 2, 9 Seeger M....Dubiel W. (1998)
- Jab1 interacts with brain-specific kinase 2 (BRSK2) an d promotes its degradation in the ubiquitin-proteasome pathway. (PubMed id 22609399)1, 2 Zhou J....Yu L. (2012)
- K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC- associated Brcc36 and proteasomal Poh1. (PubMed id 19214193)1, 2 Cooper E.M....Cohen R.E. (2009)
|
External Searches for COPS5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
|
Genome Databases showing COPS5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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|
|
Other Databases showing COPS5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing COPS5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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|
| Name | Description |
| PharmGKB entry for COPS5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for COPS5 gene:
Search GeneIP for patents involving COPS5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for COPS5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | OriGene Antibodies for COPS5 | | OriGene shRNA RFP for COPS5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COPS5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COPS5 | | | OriGene Protein Over-expression Lysate for COPS5 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for COPS5 | | OriGene 3'-UTR Clone for COPS5 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COPS5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COPS5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for COPS5 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for COPS5 | | OriGene Custom Protein Services for COPS5 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat COPS5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COPS5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COPS5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COPS5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COPS5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COPS5 |
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| | | | Search Tocris compounds for COPS5 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPS5 |
|  |  |  | | | | ThermoFisher Antibodies for COPS5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COPS5 |
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