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Aliases for COPS5 Gene

Aliases for COPS5 Gene

  • COP9 Signalosome Subunit 5 2 3
  • Jun Activation Domain-Binding Protein 1 3 4
  • Signalosome Subunit 5 3 4
  • CSN5 3 4
  • JAB1 3 4
  • SGN5 3 4
  • COP9 (Constitutive Photomorphogenic, Arabidopsis, Homolog) Subunit 5 2
  • COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) 2
  • COP9 Constitutive Photomorphogenic Homolog Subunit 5 3
  • 38 KDa Mov34 Homolog 3
  • EC 3.4.-.- 4
  • MOV-34 3

External Ids for COPS5 Gene

Previous GeneCards Identifiers for COPS5 Gene

  • GC08M067894
  • GC08M067678
  • GC08M068005
  • GC08M068117
  • GC08M063447
  • GC08M067955

Summaries for COPS5 Gene

Entrez Gene Summary for COPS5 Gene

  • The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]

GeneCards Summary for COPS5 Gene

COPS5 (COP9 Signalosome Subunit 5) is a Protein Coding gene. Diseases associated with COPS5 include hepatocellular carcinoma. Among its related pathways are DNA Damage and Hypoxic and oxygen homeostasis regulation of HIF-1-alpha. GO annotations related to this gene include transcription coactivator activity and ubiquitin-specific protease activity.

UniProtKB/Swiss-Prot for COPS5 Gene

  • Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2.

Gene Wiki entry for COPS5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COPS5 Gene

Genomics for COPS5 Gene

Regulatory Elements for COPS5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for COPS5 Gene

Chromosome:
8
Start:
67,043,079 bp from pter
End:
67,083,783 bp from pter
Size:
40,705 bases
Orientation:
Minus strand

Genomic View for COPS5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COPS5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COPS5 Gene

Proteins for COPS5 Gene

  • Protein details for COPS5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92905-CSN5_HUMAN
    Recommended name:
    COP9 signalosome complex subunit 5
    Protein Accession:
    Q92905
    Secondary Accessions:
    • O15386
    • Q6AW95
    • Q86WQ4
    • Q9BQ17

    Protein attributes for COPS5 Gene

    Size:
    334 amino acids
    Molecular mass:
    37579 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    • Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS1, COPS2, COPS4, COPS6 and COPS7 (COPS7A or COPS7B). The CSN complex interacts with the BRISC complex. Also exists as monomeric form. Interacts with TP53, MIF, JUN, UCHL1, NCOA1, HIF1A, CDKN1B, BCL3, GFER, PGR, LHCGR, SMAD4, SMAD7, ID1, ID3, ITGB2 and TOP2A. Part of a complex consisting of RANBP9, Ran, DYRK1B and COPS5. Interacts with IFIT3. Interacts with BRSK2.
    Miscellaneous:
    • The CSN complex is associated with some Lys-63-specific deubiquitination. Such activity is however not mediated by the core CSN complex but by the BRCC3/BRCC36 component of the BRISC complex
    SequenceCaution:
    • Sequence=AAL82571.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for COPS5 Gene

neXtProt entry for COPS5 Gene

Proteomics data for COPS5 Gene at MOPED

Post-translational modifications for COPS5 Gene

  • Ubiquitination at Lys 11, Lys 47, Lys 56, Lys 125, Lys 180, and Lys 236
  • Modification sites at PhosphoSitePlus

Other Protein References for COPS5 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for COPS5 (COPS5)

No data available for DME Specific Peptides for COPS5 Gene

Domains & Families for COPS5 Gene

Gene Families for COPS5 Gene

Protein Domains for COPS5 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for COPS5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92905

UniProtKB/Swiss-Prot:

CSN5_HUMAN :
  • The JAMM motif is essential for the protease activity of the CSN complex resulting in deneddylation of cullins. It constitutes the catalytic center of the complex (By similarity).
  • Belongs to the peptidase M67A family. CSN5 subfamily.
Domain:
  • The JAMM motif is essential for the protease activity of the CSN complex resulting in deneddylation of cullins. It constitutes the catalytic center of the complex (By similarity).
  • Contains 1 MPN (JAB/Mov34) domain.
Family:
  • Belongs to the peptidase M67A family. CSN5 subfamily.
genes like me logo Genes that share domains with COPS5: view

Function for COPS5 Gene

Molecular function for COPS5 Gene

UniProtKB/Swiss-Prot Function:
Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2.

Enzyme Numbers (IUBMB) for COPS5 Gene

Gene Ontology (GO) - Molecular Function for COPS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity TAS 8837781
GO:0003743 translation initiation factor activity TAS 9341143
GO:0004843 ubiquitin-specific protease activity IDA 19246649
GO:0005515 protein binding IPI 12082530
GO:0008237 metallopeptidase activity IMP 19214193
genes like me logo Genes that share ontologies with COPS5: view
genes like me logo Genes that share phenotypes with COPS5: view

Animal Models for COPS5 Gene

MGI Knock Outs for COPS5:

Animal Model Products

CRISPR Products

miRNA for COPS5 Gene

miRTarBase miRNAs that target COPS5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COPS5

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for COPS5 Gene

Localization for COPS5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COPS5 Gene

Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Note=Nuclear localization is diminished in the presence of IFIT3.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COPS5 Gene COMPARTMENTS Subcellular localization image for COPS5 gene
Compartment Confidence
nucleus 5
plasma membrane 1

Gene Ontology (GO) - Cellular Components for COPS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17050680
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 17050680
GO:0005852 eukaryotic translation initiation factor 3 complex TAS 9341143
GO:0008021 synaptic vesicle IDA 21102408
genes like me logo Genes that share ontologies with COPS5: view

Pathways & Interactions for COPS5 Gene

genes like me logo Genes that share pathways with COPS5: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for COPS5 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for COPS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000338 protein deneddylation IMP 19214193
GO:0000715 nucleotide-excision repair, DNA damage recognition TAS --
GO:0006281 DNA repair TAS --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0006289 nucleotide-excision repair TAS --
genes like me logo Genes that share ontologies with COPS5: view

Drugs & Compounds for COPS5 Gene

(1) Drugs for COPS5 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
serine Nutra 420

(1) Additional Compounds for COPS5 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
CHI 2
genes like me logo Genes that share compounds with COPS5: view

Transcripts for COPS5 Gene

Unigene Clusters for COPS5 Gene

COP9 signalosome subunit 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COPS5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COPS5 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^
SP1: - - - - - - - -
SP2: - - -
SP3: - - - - - - -
SP4:
SP5: - - - - - - - -
SP6:
SP7: - - - - - - - - - - - - - - - -
SP8: - - - - - - -
SP9: - - - - - -
SP10:
SP11: - - - - - - - - -
SP12:
SP13: - -
SP14: - - - -
SP15: - - - - -
SP16: - - - -
SP17:

ExUns: 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13a · 13b · 13c
SP1: - - - - -
SP2: - - - - -
SP3:
SP4: - - - - -
SP5:
SP6: - - - -
SP7:
SP8:
SP9:
SP10: - -
SP11:
SP12: -
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for COPS5 Gene

GeneLoc Exon Structure for
COPS5
ECgene alternative splicing isoforms for
COPS5

Expression for COPS5 Gene

mRNA expression in normal human tissues for COPS5 Gene

Protein differential expression in normal tissues from HIPED for COPS5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for COPS5 Gene



SOURCE GeneReport for Unigene cluster for COPS5 Gene Hs.491912

genes like me logo Genes that share expression patterns with COPS5: view

Protein tissue co-expression partners for COPS5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for COPS5 Gene

Orthologs for COPS5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for COPS5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia COPS5 35
  • 94.41 (n)
  • 99.7 (a)
COPS5 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COPS5 35
  • 95.01 (n)
  • 99.7 (a)
COPS5 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cops5 35
  • 91.82 (n)
  • 99.4 (a)
Cops5 16
Cops5 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia COPS5 35
  • 99.8 (n)
  • 100 (a)
COPS5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cops5 35
  • 91.32 (n)
  • 99.1 (a)
oppossum
(Monodelphis domestica)
Mammalia COPS5 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COPS5 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves COPS5 35
  • 85.19 (n)
  • 98.5 (a)
COPS5 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COPS5 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cops5 35
  • 82.63 (n)
  • 97.01 (a)
MGC76063 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.3139 35
zebrafish
(Danio rerio)
Actinopterygii cops5 35
  • 81.17 (n)
  • 96.37 (a)
zgc73130 35
cops5 36
  • 96 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CSN5 37
  • 73 (a)
CSN5 35
  • 67.08 (n)
  • 75.85 (a)
CSN5 36
  • 75 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002880 35
  • 64.92 (n)
  • 72.92 (a)
worm
(Caenorhabditis elegans)
Secernentea csn-5 35
  • 58.41 (n)
  • 59.81 (a)
csn-5 36
  • 51 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RRI1 36
  • 21 (a)
OneToOne
RRI1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons CSN5B 35
  • 64.37 (n)
  • 68.26 (a)
soybean
(Glycine max)
eudicotyledons Gma.2729 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7479 35
barley
(Hordeum vulgare)
Liliopsida Hv.8820 35
rice
(Oryza sativa)
Liliopsida Os.2223 35
Os04g0654700 35
  • 63.85 (n)
  • 68.88 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.29627 35
corn
(Zea mays)
Liliopsida Zm.3995 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4559 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00467 35
  • 55.78 (n)
  • 53.14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 79 (a)
OneToOne
Species with no ortholog for COPS5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for COPS5 Gene

ENSEMBL:
Gene Tree for COPS5 (if available)
TreeFam:
Gene Tree for COPS5 (if available)

Paralogs for COPS5 Gene

(1) SIMAP similar genes for COPS5 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for COPS5 Gene

genes like me logo Genes that share paralogs with COPS5: view

No data available for Paralogs for COPS5 Gene

Variants for COPS5 Gene

Sequence variations from dbSNP and Humsavar for COPS5 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1138477 -- 67,059,403(-) GCTCT(G/T)CTGAA reference, synonymous-codon
rs1138478 -- 67,059,367(-) GGCAA(C/T)TTGGA reference, synonymous-codon
rs4072321 -- 67,050,237(+) acctc(A/G)tgatc intron-variant
rs5892073 -- 67,050,614(+) GTGAG(-/AG/GT)TGTGT intron-variant
rs5892075 -- 67,050,768(+) GAAAG(-/A)AAAAA intron-variant

Variation tolerance for COPS5 Gene

Residual Variation Intolerance Score: 32.24% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COPS5 Gene

HapMap Linkage Disequilibrium report
COPS5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for COPS5 Gene

Disorders for COPS5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for COPS5 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
- elite association
Search COPS5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for COPS5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COPS5
genes like me logo Genes that share disorders with COPS5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for COPS5 Gene

Publications for COPS5 Gene

  1. Physical interaction of Jab1 with human serotonin 6 G-protein-coupled receptor and their possible roles in cell survival. (PMID: 20093369) Yun H.M. … Rhim H. (J. Biol. Chem. 2010) 23 67
  2. Jab1 regulates levels of endothelin type A and B receptors by promoting ubiquitination and degradation. (PMID: 20034471) Nishimoto A. … Miwa S. (Biochem. Biophys. Res. Commun. 2010) 23 67
  3. Immunohistochemically detected expression of p27(Kip1) and Skp2 predicts survival in patients with intrahepatic cholangiocarcinomas. (PMID: 19034576) Hashimoto N. … Suzuki Y. (Ann. Surg. Oncol. 2009) 23 67
  4. Expression of Jun activation domain-binding protein 1 and Ser10 phosphorylated p27 protein in human epithelial ovarian carcinoma. (PMID: 19139918) Wang Y. … Shen A. (J. Cancer Res. Clin. Oncol. 2009) 23 67
  5. Significance of Jab1 expression in human esophageal squamous cell carcinoma. (PMID: 19349901) Wang F. … Shen A. (J. Clin. Gastroenterol. 2009) 23 67

Products for COPS5 Gene

Sources for COPS5 Gene

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