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COPS5 Gene

protein-coding   GIFtS: 63
GCID: GC08M067955

COP9 Signalosome Subunit 5

(Previous names: COP9 (constitutive photomorphogenic, Arabidopsis, homolog)...)
  See COPS5-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
COP9 Signalosome Subunit 51 2     COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis)1
JAB12 3 5     38 KDa Mov34 Homolog2
SGN52 3 5     MOV-342
Jun Activation Domain-Binding Protein 12 3     COP9 Constitutive Photomorphogenic Homolog Subunit 52
Signalosome Subunit 52 3     COP9 Signalosome Complex Subunit 52
CSN52 3     EC 3.4.-.-3
COP9 (Constitutive Photomorphogenic, Arabidopsis, Homolog) Subunit 51     

External Ids:    HGNC: 22401   Entrez Gene: 109872   Ensembl: ENSG000001210227   OMIM: 6048505   UniProtKB: Q929053   
ORGUL members:         

Export aliases for COPS5 gene to outside databases

Previous GC identifers: GC08M067077 GC08M067894 GC08M067678 GC08M068005 GC08M068117 GC08M063447


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for COPS5 Gene:
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein
complex that functions as an important regulator in multiple signaling pathways. The structure and function of
COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been
shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases.
This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1.
It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. (provided
by RefSeq, Jul 2008)

GeneCards Summary for COPS5 Gene:
COPS5 (COP9 signalosome subunit 5) is a protein-coding gene. Diseases associated with COPS5 include thyroid medullary carcinoma. GO annotations related to this gene include transcription coactivator activity and translation initiation factor activity.

UniProtKB/Swiss-Prot: CSN5_HUMAN, Q92905
Function: Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular
and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway
by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease
the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in
phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with
CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl
system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of
Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the
CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming
a key role in the complex. Promotes the proteasomal degradation of BRSK2

Gene Wiki entry for COPS5 (COP9 constitutive photomorphogenic homolog subunit 5) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_008183.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the COPS5 gene promoter:
         HFH-3   Pax-2   CUTL1   Pax-2a   YY1   FOXI1   MEF-2A   NRF-2   Pax-2b   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOPS5 promoter sequence
   Search Chromatin IP Primers for COPS5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COPS5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q13.1   Ensembl cytogenetic band:  8q13.1   HGNC cytogenetic band: 8q13.1

COPS5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COPS5 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M067955:  view genomic region     (about GC identifiers)

Start:
67,955,314 bp from pter      End:
67,996,018 bp from pter
Size:
40,705 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CSN5_HUMAN, Q92905 (See protein sequence)
Recommended Name: COP9 signalosome complex subunit 5  
Size: 334 amino acids; 37579 Da
Cofactor: Divalent metal ions (By similarity)
Subunit: Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or
COPS7B) and COPS8. In the complex, it probably interacts directly with COPS1, COPS2, COPS4, COPS6 and COPS7
(COPS7A or COPS7B). The CSN complex interacts with the BRISC complex. Also exists as monomeric form. Interacts
with TP53, MIF, JUN, UCHL1, NCOA1, HIF1A, CDKN1B, BCL3, GFER, PGR, LHCGR, SMAD4, SMAD7, ID1, ID3, ITGB2 and
TOP2A. Part of a complex consisting of RANBP9, Ran, DYRK1B and COPS5. Interacts with IFIT3. Interacts with BRSK2
Miscellaneous: The CSN complex is associated with some 'Lys-63'-specific deubiquitination. Such activity is
however not mediated by the core CSN complex but by the BRCC3/BRCC36 component of the BRISC complex
Sequence caution: Sequence=AAL82571.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for COPS5:
4F7O (3D)    
Secondary accessions: O15386 Q6AW95 Q86WQ4 Q9BQ17

Explore the universe of human proteins at neXtProt for COPS5: NX_Q92905

Explore proteomics data for COPS5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys11, Lys47, Lys56, Lys125, Lys180, Lys236
  • Modification sites at PhosphoSitePlus

  • See COPS5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006828.2  
    ENSEMBL proteins: 
     ENSP00000350512   ENSP00000429774   ENSP00000427869   ENSP00000427997   ENSP00000428586  
     ENSP00000428124  

    COPS5 Human Recombinant Protein Products:

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    GenScript Custom Purified and Recombinant Proteins Services for COPS5
    Novus Biologicals COPS5 Protein
    Novus Biologicals COPS5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for COPS5

     
    Search eBioscience for Proteins for COPS5 

     
    antibodies-online proteins for COPS5 (7 products) 

     
    antibodies-online peptides for COPS5

    COPS5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for COPS5 (JAB1)
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    OriGene Custom Antibody Services for COPS5
    Novus Biologicals COPS5 Antibodies
    Abcam antibodies for COPS5
    Cloud-Clone Corp. Antibodies for COPS5
    ThermoFisher Antibody for COPS5
    antibodies-online antibodies for COPS5 (77 products) 

    COPS5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for COPS5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for COPS5
    Cloud-Clone Corp. CLIAs for COPS5
    Search eBioscience for ELISAs for COPS5 
    antibodies-online kits for COPS5 (5 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000555 JAB_MPN_dom

    Graphical View of Domain Structure for InterPro Entry Q92905

    ProtoNet protein and cluster: Q92905

    1 Blocks protein domain: IPB000555 Mov34 family

    UniProtKB/Swiss-Prot: CSN5_HUMAN, Q92905
    Domain: The JAMM motif is essential for the protease activity of the CSN complex resulting in deneddylation of
    cullins. It constitutes the catalytic center of the complex (By similarity)
    Similarity: Belongs to the peptidase M67A family. CSN5 subfamily
    Similarity: Contains 1 MPN (JAB/Mov34) domain


    Find genes that share domains with COPS5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CSN5_HUMAN, Q92905
    Function: Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular
    and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway
    by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease
    the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in
    phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with
    CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl
    system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of
    Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the
    CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming
    a key role in the complex. Promotes the proteasomal degradation of BRSK2

         Enzyme Number (IUBMB): EC 3.4.-.-1

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity TAS8837781
    GO:0003743translation initiation factor activity TAS9341143
    GO:0004843ubiquitin-specific protease activity IDA19246649
    GO:0005515protein binding IPI12082530
    GO:0008237metallopeptidase activity IMP19214193
         
    Find genes that share ontologies with COPS5           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for COPS5:
     Increased cell death in HCT116  Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Cops5):
     cellular  embryogenesis  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  normal 

    Find genes that share phenotypes with COPS5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for COPS5: Cops5tm1Jka Cops5tm1Fxc

       genOway: Develop your customized and physiologically relevant rodent model for COPS5

    miRNA
    Products:
        
    miRTarBase miRNAs that target COPS5:
    hsa-mir-10b-5p (MIRT047407), hsa-mir-16-5p (MIRT031695)

    Block miRNA regulation of human, mouse, rat COPS5 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate COPS5:
    hsa-miR-582-3p
    SwitchGear 3'UTR luciferase reporter plasmidCOPS5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for COPS5
    Predesigned siRNA for gene silencing in human, mouse, rat COPS5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for COPS5

    Clone
    Products:
         
    OriGene clones in human, mouse for COPS5 (see all 7)
    OriGene ORF clones in mouse, rat for COPS5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: COPS5 (NM_006837)
    Sino Biological Human cDNA Clone for COPS5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COPS5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COPS5
    Addgene plasmids for COPS5 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for COPS5
    Browse ESI BIO Cell Lines and PureStem Progenitors for COPS5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPS5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CSN5_HUMAN, Q92905: Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Note=Nuclear localization is diminished
    in the presence of IFIT3
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA17050680
    GO:0005852eukaryotic translation initiation factor 3 complex TAS9341143
    GO:0008180COP9 signalosome IDA18850735

    Find genes that share ontologies with COPS5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for COPS5 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Cell cycle Regulation of G1 S transition part 2
    Immune response MIF JAB1 signaling0.32
    2Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32
    3TGF-beta Receptor Signaling Pathway
    TGF-beta Receptor Signaling Pathway
    4Protein Stability
    Protein Stability
    5MIF Action Through Endocytic Pathway
    MIF Action Through Endocytic Pathway


    Find genes that share SuperPaths with COPS5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for COPS5
        HIF1Alpha Pathway
    MIF Action Through Endocytic Pathway

    2 Cell Signaling Technology (CST) Pathways for COPS5
        Cell Cycle / Checkpoint Control
    Protein Stability

    1 GeneGo (Thomson Reuters) Pathway for COPS5
        Immune response MIF-JAB1 signaling

    3 BioSystems Pathways for COPS5
        TGF-beta Receptor Signaling Pathway
    HIF-1-alpha transcription factor network
    Hypoxic and oxygen homeostasis regulation of HIF-1-alpha



        Pathway & Disease-focused RT2 Profiler PCR Array including COPS5: 
              Hypoxia Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for COPS5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for COPS5 (Q929051, 2, 3 ENSP000003505124) via UniProtKB, MINT, STRING, and/or I2D (see all 1121)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000237724P081073, ENSP000004063594I2D: score=1 STRING: ENSP00000406359
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000338protein deneddylation IMP19214193
    GO:0006366transcription from RNA polymerase II promoter TAS8837781
    GO:0006412translation TAS9341143
    GO:0006413translational initiation TAS9341143
    GO:0006508proteolysis ----

    Find genes that share ontologies with COPS5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for COPS5 (CSN5)

    2 Novoseek inferred chemical compound relationships for COPS5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chi 2 20.1 2 15154004 (1), 15887118 (1)
    serine 0 1 12119282 (1)



    Find genes that share compounds with COPS5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for COPS5 gene: 
    NM_006837.2  

    Unigene Cluster for COPS5:

    COP9 signalosome subunit 5
    Hs.491912  [show with all ESTs]
    Unigene Representative Sequence: AB209134
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000523086 ENST00000357849(uc003xxe.3 uc010lyv.1) ENST00000521509(uc003xxd.3 uc003xxf.3)
    ENST00000517736 ENST00000521386 ENST00000518374 ENST00000523890(uc010lyu.1)
    ENST00000518747 ENST00000517793 ENST00000517406 ENST00000519963 ENST00000519057
    ENST00000518768
    miRNA
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    Block miRNA regulation of human, mouse, rat COPS5 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate COPS5:
    hsa-miR-582-3p
    SwitchGear 3'UTR luciferase reporter plasmidCOPS5 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: COPS5 (NM_006837)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COPS5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COPS5
    Addgene plasmids for COPS5 
    Primer
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    OriGene qPCR primer pairs and template standards for COPS5
    OriGene qSTAR qPCR primer pairs in human, mouse for COPS5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat COPS5
      QuantiTect SYBR Green Assays in human, mouse, rat COPS5
      QuantiFast Probe-based Assays in human, mouse, rat COPS5

    Additional mRNA sequence: 

    AB209134.1 AK056967.1 AK128519.1 AK310434.1 AK311071.1 BC001187.1 BC001859.2 BC007272.1 
    BX648542.1 CR541678.1 U65928.1 U70734.1 

    19 DOTS entries:

    DT.445035  DT.100811298  DT.91922156  DT.95370546  DT.75193043  DT.100745730  DT.120640472  DT.120640468 
    DT.92452030  DT.95370541  DT.97854658  DT.100811295  DT.120640614  DT.91740752  DT.120640486  DT.95370549 
    DT.86855098  DT.95370540  DT.95370548 

    Selected AceView cDNA sequences (see all 546):

    BI912490 BQ053204 BU781980 T36085 CA418572 BQ268267 BM451856 BE728239 
    CR541678 BM699817 CB306321 BU071441 CB852955 BQ054578 CA865741 BQ934060 
    BM983562 N90861 BU687678 BU541313 BQ775996 BP334481 BE276811 BQ010969 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for COPS5 (see all 17)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^
    SP1:                                                        -     -     -     -     -     -     -     -                                                         
    SP2:                                                                                      -     -     -                                                         
    SP3:                                                              -     -     -     -     -     -     -                                                         
    SP4:                                                                                                                                                            
    SP5:                                                        -     -     -     -     -     -     -     -                                                         

    ExUns: 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13a · 13b · 13c
    SP1:        -     -     -     -           -                     
    SP2:        -     -     -     -           -                     
    SP3:                                                            
    SP4:        -     -     -     -           -                     
    SP5:                                                            


    ECgene alternative splicing isoforms for COPS5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    COPS5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATTGATGTC
    COPS5 Expression
    About this image


    COPS5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    COPS5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    COPS5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.491912
        Pathway & Disease-focused RT2 Profiler PCR Array including COPS5: 
              Hypoxia Signaling Pathway in human mouse rat

    Primer
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPS5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for COPS5 gene from Selected species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cops51 , 5 COP9 (constitutive photomorphogenic) homolog, subunit more1, 5 91.82(n)1
    99.4(a)1
      1 (2.29 cM)5
    267541  NM_013715.21  NP_038743.11 
     100246025 
    chicken
    (Gallus gallus)
    Aves COPS51 COP9 constitutive photomorphogenic homolog subunit more 85.19(n)
    98.5(a)
      426579  NM_001039311.1  NP_001034400.1 
    lizard
    (Anolis carolinensis)
    Reptilia COPS56
    COP9 signalosome subunit 5
    97(a)
    1 ↔ 1
    4(31089926-31102151)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.31392 Xenopus laevis transcribed sequence with strong similarity more 82.39(n)    CD253707.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc731302 hypothetical protein MGC73130 81.88(n)   393698  BC059493.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CSN51 , 3 axonogenesis3
    COP9 complex homolog subunit 51
    73(a)3
    67.08(n)1
    75.85(a)1
      420001  NM_058094.51  NP_477442.11 
    worm
    (Caenorhabditis elegans)
    Secernentea csn-51 csn-5 58.41(n)
    59.81(a)
      177342  NM_068440.4  NP_500841.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RRI1(YDL216C)4 Catalytic subunit of the COP9 signalosome (CSN) complex more   --   4(70319-68997) 851310  NP_010065.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CSN5B1 CSN5B 64.37(n)
    68.26(a)
      843463  NM_105792.1  NP_177279.1 
    rice
    (Oryza sativa)
    Liliopsida Os.22232 Oryza sativa subsp. indica jab1 protein (jab1) mRNA, more 74.38(n)    AF072849.1 


    ENSEMBL Gene Tree for COPS5 (if available)
    TreeFam Gene Tree for COPS5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for COPS5 gene
    1 SIMAP similar gene for COPS5 using alignment to 6 protein entries:     CSN5_HUMAN (see all proteins):
    PSMD14

    Find genes that share paralogs with COPS5           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for COPS5
    PGOHUM00000239598 PGOHUM00000243296


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for COPS5 (see all 335)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1401201031,2
    C--67954840(+) AAGTTA/CTTGTT 1 -- ds50010--------
    rs1437228241,2
    --67954856(+) AGCTTC/TAGCCT 1 -- ds50010--------
    rs1468141261,2
    C--67955048(+) GTTTTA/GTAGGA 1 -- ds50010--------
    rs119982811,2
    C,F,H--67955164(+) TCAGTA/GTGGCA 1 -- ds50018Minor allele frequency- G:0.02NS EA NA WA 634
    rs1909452671,2
    --67955167(+) GTATGC/GCAAGT 1 -- ds50010--------
    rs1405513351,2
    --67955173(+) CAAGTA/GAAATG 1 -- ds50010--------
    rs70006501,2
    C,F,H--67955258(+) AGAACC/TGTAAT 1 -- ds500117Minor allele frequency- T:0.06NS EA NA CSA WA 2116
    rs753817391,2
    C--67955472(+) TTTAAG/TAGATG 2 Y S mis10--------
    rs1380190041,2
    C,F--67955495(+) AACAGT/CTTATC 2 /K syn12Minor allele frequency- C:0.00NA EU 5743
    rs2001556281,2
    --67955556(+) GCTGG-/AAAAAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for COPS5 (67955314 - 67996018 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for COPS5: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing COPS5
    DNA2.0 Custom Variant and Variant Library Synthesis for COPS5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604850    OMIM disorders: --

    1 disease for COPS5:    
    About MalaCards
    thyroid medullary carcinoma


    Find genes that share disorders with COPS5           About GenesLikeMe

    Selected Novoseek inferred disease relationships for COPS5 gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 40.2 71 11751512 (5), 19461157 (5), 14654548 (3), 12631617 (3) (see all 29)
    cancer 35.8 24 17027978 (2), 19461157 (2), 17914096 (2), 17203996 (2) (see all 11)
    hepatocellular carcinoma 27.6 5 19080643 (2), 18346358 (1), 17651785 (1), 16000397 (1)
    benign tumor 25.8 2 11751512 (1), 19139918 (1)
    pancreatic cancer 25.1 12 17027978 (3), 19395473 (2), 16951171 (2), 14719054 (2)
    ovarian carcinoma 24.3 2 19139918 (1), 16525656 (1)
    lymphoma 21.9 10 14666612 (5), 18246793 (3), 12631617 (1), 18285702 (1)
    breast cancer 19.9 23 14654548 (4), 18534028 (4), 18246048 (3), 17914096 (3) (see all 6)
    breast carcinoma 12.7 8 12782606 (3), 14654548 (2), 15217497 (1)
    adenoma 8.75 1 12860294 (1)


    Export disorders for COPS5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for COPS5 gene, integrated from 10 sources (see all 232):
    (articles sorted by number of sources associating them with COPS5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly. (PubMed id 9341143)1, 2, 3 Asano K.... Hershey J.W.B. (J. Biol. Chem. 1997)
    2. A new group of conserved coactivators that increase the specificity of AP-1 transcription factors. (PubMed id 8837781)1, 2, 3 Claret F.-X.... Karin M. (Nature 1996)
    3. Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1. (PubMed id 11089976)1, 2, 9 Kleemann R.... Bernhagen J. (Nature 2000)
    4. Intracrine hepatopoietin potentiates AP-1 activity through JAB1 independent of MAPK pathway. (PubMed id 11709497)1, 2, 9 Lu C.... He F. (FASEB J. 2002)
    5. Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation. (PubMed id 11818334)1, 2, 9 Wan M.... Cao X. (EMBO Rep. 2002)
    6. Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity. (PubMed id 10766246)1, 2, 9 Bianchi E.... Pardi R. (Nature 2000)
    7. RIG-G as a key mediator of the antiproliferative activity of interferon-related pathways through enhancing p21 and p27 proteins. (PubMed id 17050680)1, 2, 9 Xiao S.... Tong J.H. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    8. A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. (PubMed id 9535219)1, 2, 9 Seeger M.... Dubiel W. (FASEB J. 1998)
    9. Jab1 interacts with brain-specific kinase 2 (BRSK2) and promotes its degradation in the ubiquitin-proteasome pathway. (PubMed id 22609399)1, 2 Zhou J.... Yu L. (Biochem. Biophys. Res. Commun. 2012)
    10. K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC- associated Brcc36 and proteasomal Poh1. (PubMed id 19214193)1, 2 Cooper E.M....Cohen R.E. (EMBO J. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10987 HGNC: 2240 AceView: COPS5 Ensembl:ENSG00000121022 euGenes: HUgn10987
    ECgene: COPS5 H-InvDB: COPS5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for COPS5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for COPS5 gene:
    Search GeneIP for patents involving COPS5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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