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Aliases for COPS4 Gene

Aliases for COPS4 Gene

  • COP9 Signalosome Subunit 4 2 3
  • JAB1-Containing Signalosome Subunit 4 3 4
  • Signalosome Subunit 4 3 4
  • CSN4 3 4
  • SGN4 3 4
  • COP9 (Constitutive Photomorphogenic, Arabidopsis, Homolog) Subunit 4 2
  • COP9 Constitutive Photomorphogenic Homolog Subunit 4 (Arabidopsis) 2
  • COP9 Constitutive Photomorphogenic Homolog Subunit 4 3
  • COP9 Signalosome Complex Subunit 4 3

External Ids for COPS4 Gene

Previous GeneCards Identifiers for COPS4 Gene

  • GC04P083880
  • GC04P084249
  • GC04P084348
  • GC04P084414
  • GC04P084313
  • GC04P083955
  • GC04P079696

Summaries for COPS4 Gene

Entrez Gene Summary for COPS4 Gene

  • This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

GeneCards Summary for COPS4 Gene

COPS4 (COP9 Signalosome Subunit 4) is a Protein Coding gene.

UniProtKB/Swiss-Prot for COPS4 Gene

  • Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Gene Wiki entry for COPS4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COPS4 Gene

Genomics for COPS4 Gene

Regulatory Elements for COPS4 Gene

Genomic Location for COPS4 Gene

Start:
83,034,447 bp from pter
End:
83,075,818 bp from pter
Size:
41,372 bases
Orientation:
Plus strand

Genomic View for COPS4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COPS4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COPS4 Gene

Proteins for COPS4 Gene

  • Protein details for COPS4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BT78-CSN4_HUMAN
    Recommended name:
    COP9 signalosome complex subunit 4
    Protein Accession:
    Q9BT78
    Secondary Accessions:
    • B3KN88
    • B3KST5
    • Q561W7
    • Q9NW31
    • Q9Y677

    Protein attributes for COPS4 Gene

    Size:
    406 amino acids
    Molecular mass:
    46269 Da
    Quaternary structure:
    • Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS1, COPS2, COPS3, COPS5, COPS6, COPS7 (COPS7A or COPS7B) and COPS8. Interacts with TOR1A; the interaction is direct and associates TOR1A and SNAPIN with the CSN complex. Interacts with STON2; controls STON2 neddylation levels.

    Three dimensional structures from OCA and Proteopedia for COPS4 Gene

    Alternative splice isoforms for COPS4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COPS4 Gene

Proteomics data for COPS4 Gene at MOPED

Post-translational modifications for COPS4 Gene

  • Ubiquitination at Lys20, Lys227, Lys266, and Lys372
  • Modification sites at PhosphoSitePlus

Other Protein References for COPS4 Gene

No data available for DME Specific Peptides for COPS4 Gene

Domains for COPS4 Gene

Protein Domains for COPS4 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9BT78

UniProtKB/Swiss-Prot:

CSN4_HUMAN :
  • Q9BT78
Domain:
  • Contains 1 PCI domain.
Family:
  • Belongs to the CSN4 family.
genes like me logo Genes that share domains with COPS4: view

No data available for Gene Families for COPS4 Gene

Function for COPS4 Gene

Molecular function for COPS4 Gene

UniProtKB/Swiss-Prot Function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Gene Ontology (GO) - Molecular Function for COPS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with COPS4: view
genes like me logo Genes that share phenotypes with COPS4: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COPS4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for COPS4 Gene

Localization for COPS4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COPS4 Gene

Cytoplasm. Nucleus. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COPS4 Gene COMPARTMENTS Subcellular localization image for COPS4 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for COPS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0008021 synaptic vesicle IDA 21102408
GO:0008180 COP9 signalosome IDA 18850735
GO:0030054 cell junction IDA --
genes like me logo Genes that share ontologies with COPS4: view

Pathways for COPS4 Gene

SuperPathways for COPS4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for COPS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000338 protein deneddylation IMP 21102408
GO:0010388 cullin deneddylation IDA 19141280
genes like me logo Genes that share ontologies with COPS4: view

No data available for Pathways by source for COPS4 Gene

Transcripts for COPS4 Gene

Unigene Clusters for COPS4 Gene

COP9 signalosome subunit 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COPS4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COPS4 Gene

No ASD Table

Relevant External Links for COPS4 Gene

GeneLoc Exon Structure for
COPS4
ECgene alternative splicing isoforms for
COPS4

Expression for COPS4 Gene

mRNA expression in normal human tissues for COPS4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COPS4 Gene

SOURCE GeneReport for Unigene cluster for COPS4 Gene Hs.190384

genes like me logo Genes that share expressions with COPS4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for COPS4 Gene

Orthologs for COPS4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for COPS4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COPS4 35
  • 99.67 (n)
  • 100 (a)
COPS4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia COPS4 35
  • 95.4 (n)
  • 99.75 (a)
COPS4 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COPS4 35
  • 95.48 (n)
  • 100 (a)
COPS4 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cops4 35
  • 90.64 (n)
  • 99.51 (a)
Cops4 16
Cops4 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia COPS4 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 95 (a)
OneToMany
-- 36
  • 98 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cops4 35
  • 88.92 (n)
  • 99.01 (a)
chicken
(Gallus gallus)
Aves COPS4 35
  • 84.07 (n)
  • 99.01 (a)
COPS4 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COPS4 36
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.33935 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cops4 35
  • 80.05 (n)
  • 96.55 (a)
zebrafish
(Danio rerio)
Actinopterygii cops4 35
  • 78.65 (n)
  • 94.58 (a)
cops4 36
  • 95 (a)
OneToOne
wufc90c08 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009834 35
  • 63.61 (n)
  • 72.03 (a)
fruit fly
(Drosophila melanogaster)
Insecta CSN4 35
  • 64.38 (n)
  • 72.34 (a)
CSN4 36
  • 70 (a)
OneToOne
CSN4 37
  • 72 (a)
worm
(Caenorhabditis elegans)
Secernentea csn-4 36
  • 36 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons COP8 35
  • 55.11 (n)
  • 51.32 (a)
rice
(Oryza sativa)
Liliopsida Os03g0197400 35
  • 55.77 (n)
  • 53.02 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2409 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 68 (a)
OneToOne
Species with no ortholog for COPS4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for COPS4 Gene

ENSEMBL:
Gene Tree for COPS4 (if available)
TreeFam:
Gene Tree for COPS4 (if available)

Paralogs for COPS4 Gene

No data available for Paralogs for COPS4 Gene

Variants for COPS4 Gene

Sequence variations from dbSNP and Humsavar for COPS4 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1531239 -- 83,047,264(-) gccac(C/T)gtgcc intron-variant
rs1962156 -- 83,062,096(+) TGATA(C/G)GATCA intron-variant
rs1962413 -- 83,059,410(+) GACCC(C/G)TTTAC intron-variant
rs2868734 -- 83,055,062(+) CCATT(C/T)TCCTT intron-variant
rs2868735 -- 83,055,063(+) CATTC(C/T)CCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COPS4 Gene

Variant ID Type Subtype PubMed ID
nsv829990 CNV Gain 17160897
esv2658715 CNV Deletion 23128226

Relevant External Links for COPS4 Gene

HapMap Linkage Disequilibrium report
COPS4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COPS4 Gene

Disorders for COPS4 Gene

No disorders were found for COPS4 Gene.

No data available for UniProtKB/Swiss-Prot for COPS4 Gene

Publications for COPS4 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. (PMID: 9535219) Seeger M. … Dubiel W. (FASEB J. 1998) 3 4
  3. The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex. (PMID: 9707402) Wei N. … Deng X.W. (Curr. Biol. 1998) 2 3
  4. Aberrant expression of signaling-related proteins 14-3-3 gamma and RACK1 in fetal Down syndrome brain (trisomy 21), AND MASS SPECTROMETRY. (PMID: 11824616) Peyrl A. … Lubec G. (Electrophoresis 2002) 3 4
  5. Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. (PMID: 18850735) Fang L. … Huang L. (J. Proteome Res. 2008) 3 4

Products for COPS4 Gene

Sources for COPS4 Gene

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