COPS3 Gene

Aliases
for COPS3 gene

Previous GC identifers: GC17M017465 GC17M018509 GC17M017093 GC17M017350 GC17M017090 GC17M016903

Summaries
for COPS3 gene

Genomic Views
for COPS3 gene

RefSeq DNA sequence:

NC_000017.10  NC_018928.1  NT_010718.16  

SwitchGear Promoter luciferase reporter plasmid: COPS3 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COPS3

COPS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M017151:  view genomic region     (about GC identifiers)

Proteins
for COPS3 gene

Explore the universe of human proteins at neXtProt for COPS3: NX_Q9UNS2

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: COPS3 OriGene Custom Protein Services for COPS3
	GenScript Custom Purified and Recombinant Proteins Services for COPS3
	Novus Biologicals COPS3 Proteins Novus Biologicals COPS3 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for COPS3

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies: COPS3 OriGene Custom Antibody Services for COPS3
	GenScript Custom Superior Antibodies Services for COPS3
	Novus Biologicals COPS3 Antibodies
	Abcam antibodies for COPS3
	Uscn Antibodies for COPS3
	ThermoFisher Antibodies for COPS3

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for COPS3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for COPS3

Protein Domains /
Families
for COPS3 gene

ProtoNet protein and cluster: Q9UNS2

Function
for COPS3 gene

miRNA Products:		OriGene 3'-UTR Clone: COPS3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COPS3
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate COPS3 (see all 10):
		hsa-miR-3678-3p hsa-miR-3200-5p hsa-miR-3679-5p hsa-miR-125a-3p hsa-miR-605 hsa-miR-4290 hsa-miR-1185 hsa-miR-548m
		SwitchGear 3'UTR luciferase reporter plasmid: COPS3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COPS3 (see all 7) OriGene shRNA RFP: COPS3 OriGene siRNA: COPS3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COPS3

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for COPS3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COPS3 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COPS3 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): COPS3 (NM_003653)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for COPS3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COPS3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for COPS3
		Search LifeMap BioReagents cell lines for COPS3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPS3

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

(inferred from 2 alleles) (MGI details for Cops3)

Pathways & Interactions
for COPS3 gene

	Super-pathway	contained gene-specific pathways
1	TNF-alpha/NF-kB Signaling Pathway	TNF-alpha/NF-kB Signaling Pathway 1.00

1 BioSystems Pathway for COPS3

TNF-alpha/NF-kB Signaling Pathway

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for COPS3 gene

Transcripts
for COPS3 gene

Expression
for COPS3 gene

COPS3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACCAGGAGA

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	BoneMaxillary Process			Bone
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	Intermediate limb mesenchymal cells (ILM cells) (Primary Cell)			Bone, Cartilage, Limb

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COPS3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat COPS3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COPS3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COPS3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPS3

Orthologs
for COPS3 gene

Paralogs
for COPS3 gene

Paralogs for COPS3 gene

COPS3 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for COPS3
PGOHUM00000245791

Genomic Variants
for COPS3 gene

10/654 NCBI SNPs in COPS3 are shown (see all 654)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1811504981,2		--	17149561(+)	GTGCTC/TGCCTG	2	--	ds5001		0	--	--	--	--
rs1175329071,2		--	17149562(+)	TGCTCG/ACCTGT	2	--	ds5001		1		EA	120
rs1394210571,2		--	17149650(+)	TGCACC/TGCAGC	2	--	ds5001		0	--	--	--	--
rs1180577531,2		--	17149714(+)	CCAATG/AGCATC	2	--	ds5001		1		NA	120
rs768497411,2		--	17149818(+)	TTTTTG/TTAAAC	2	--	ds5001		1		NA	2
rs1499733901,2		--	17149819(+)	TTTTGG/TAAACA	2	--	ds5001		0	--	--	--	--
rs1866494631,2		--	17149856(+)	AGGTGA/GTCTGA	2	--	ds5001		0	--	--	--	--
rs2004086831,2		--	17149942(+)	CTGGC-/CTTT           CTTTT	2	--	ut31		0	--	--	--	--
rs1905920661,2		--	17150122(+)	TGATAC/GAGAAG	2	--	ut31		0	--	--	--	--
rs1810482211,2		--	17150207(+)	TCCACA/GACAGA	2	--	ut31		0	--	--	--	--

HapMap Linkage Disequilibrium report for COPS3 (17150139 - 17184607 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for COPS3
     1 CNV: 30805
     1 Inversion: 0495

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COPS3

DNA2.0 Custom Variant and Variant Library Synthesis for COPS3

Disorders / Diseases
for COPS3 gene

8 diseases for COPS3

1 Novoseek disease relationship for COPS3 gene    About this table

Publications
for COPS3 gene

PubMed articles for COPS3 gene, integrated from 9 sources (see all 79): (articles sorted by number of sources associating them with COPS3)

Utopia: connect your pdf to the dynamic world of online information

1. Subunit 3 of the COP9 signal transduction complex is conserved from plants to humans and maps within the smith-magenis syndrome critical region in 17p11.2. (PubMed id 10191102)^{1, 2, 3} Potocki L.... Lupski J.R. (1999)
2. A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. (PubMed id 9535219)^{1, 2, 3} Seeger M....Dubiel W. (1998)
3. Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome. (PubMed id 12220626)^{1, 2, 9} Hoareau Alves K.... Jalinot P. (2002)
4. Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. (PubMed id 18850735)^{1, 2} Fang L.... Huang L. (2008)
5. Amplification and overexpression of genes in 17p11.2 approximately p12 in osteosarcoma. (PubMed id 15325100)^{1, 2} Van Dartel M. and Hulsebos T.J.M. (2004)
6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
7. Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome. (PubMed id 12628923)^{1, 2} Uhle S....Dubiel W. (2003)
8. The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. (PubMed id 12732143)^{1, 2} Groisman R.... Nakatani Y. (2003)
9. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{1, 2} Gevaert K.... Vandekerckhove J. (2003)
10. Amplification and overexpression of COPS3 in osteosarcomas potentially target TP53 for proteasome-mediated degradation. (PubMed id 12917637)^{1, 2} Henriksen J....Forus A. (2003)

External Searches for COPS3 gene

Genome Databases showing COPS3 gene

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Products
for COPS3 gene