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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

COPS3 Gene

protein-coding   GIFtS: 58
GCID: GC17M017151

COP9 Signalosome Subunit 3

(Previous names: COP9 (constitutive photomorphogenic, Arabidopsis, homolog)...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
COP9 Signalosome Subunit 31 2     COP9 (Constitutive Photomorphogenic, Arabidopsis, Homolog) Subunit 31
SGN32 3 5     COP9 Constitutive Photomorphogenic Homolog Subunit 3 (Arabidopsis)1
Signalosome Subunit 32 3     COP9 Complex Subunit 32
CSN32 3     COP9 Constitutive Photomorphogenic Homolog Subunit 32
JAB1-Containing Signalosome Subunit 32 3     COP9 Signalosome Complex Subunit 32

External Ids:    HGNC: 22391   Entrez Gene: 85332   Ensembl: ENSG000001410307   OMIM: 6046655   UniProtKB: Q9UNS23   

Export aliases for COPS3 gene to outside databases

Previous GC identifers: GC17M017465 GC17M018509 GC17M017093 GC17M017350 GC17M017090 GC17M016903


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for COPS3 Gene:
The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal
transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated
phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, Nov 2010)

GeneCards Summary for COPS3 Gene: 
COPS3 (COP9 signalosome subunit 3) is a protein-coding gene. Diseases associated with COPS3 include small cell osteogenic sarcoma, and smith magenis syndrome. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: CSN3_HUMAN, Q9UNS2
Function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and
developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by
mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl
ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation
of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD
kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system,
respectively

Gene Wiki entry for COPS3 (COP9 signalosome complex subunit 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010718.16  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the COPS3 gene promoter:
         p53   p300   CBF-C   CREB   NRF-2   CBF-A   CBF-B   CP1C   CP1A   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOPS3 promoter sequence
   Search SABiosciences Chromatin IP Primers for COPS3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COPS3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2   Ensembl cytogenetic band:  17p11.2   HGNC cytogenetic band: 17p11.2

COPS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COPS3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M017151:  view genomic region     (about GC identifiers)

Start:
17,149,938 bp from pter      End:
17,184,617 bp from pter
Size:
34,680 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CSN3_HUMAN, Q9UNS2 (See protein sequence)
Recommended Name: COP9 signalosome complex subunit 3  
Size: 423 amino acids; 47873 Da
Subunit: Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or
COPS7B) and COPS8. In the complex, it probably interacts directly with COPS1, COPS4 and COPS8. Interacts with CK2
and PKD. Interacts with the translation initiation factor EIF3S6 and IKBKG
Subcellular location: Cytoplasm. Nucleus
Miscellaneous: Amplified and overexpressed in some osteosarcomas (OS), suggesting that it may participate in TP53
degradation in OS
Sequence caution: Sequence=AAC14197.1; Type=Frameshift; Positions=5;
Secondary accessions: B2R683 B4DY81 O43191 Q7LDR6
Alternative splicing: 2 isoforms:  Q9UNS2-1   Q9UNS2-2   

Explore the universe of human proteins at neXtProt for COPS3: NX_Q9UNS2

Explore proteomics data for COPS3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UNS2

  • COPS3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    COPS3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001186054.1  NP_003644.2  

    ENSEMBL proteins: 
     ENSP00000437606   ENSP00000466153   ENSP00000268717   ENSP00000464572   ENSP00000413298  
     ENSP00000463340   ENSP00000409028   ENSP00000463098   ENSP00000468536   ENSP00000463477  
     ENSP00000463195   ENSP00000464369   ENSP00000465156  

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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for COPS3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0008180COP9 signalosome IDA18850735

    COPS3 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for COPS3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR000717 PCI_dom
     IPR011991 WHTH_DNA-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q9UNS2

    ProtoNet protein and cluster: Q9UNS2

    1 Blocks protein domain: IPB000717 Domain in components of the proteasome

    UniProtKB/Swiss-Prot: CSN3_HUMAN, Q9UNS2
    Similarity: Belongs to the CSN3 family
    Similarity: Contains 1 PCI domain


    COPS3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CSN3_HUMAN, Q9UNS2
    Function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and
    developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by
    mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl
    ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation
    of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD
    kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system,
    respectively

         Genatlas biochemistry entry for COPS3:
    COP9 (constitutive photomorphogenic,Arabidopsis) homolog subunit 3,ubiquitously expressed,predominantly in cardiac
    and skeletal muscle,involved in signal transduction,within the Smith-Magenis critical region

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11418127
         
    COPS3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for COPS3:
     Increased cell death in HCC-19  Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cops3):
     embryogenesis  growth/size  mortality/aging 

    COPS3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for COPS3: Cops3tm1Jrl Cops3tm2Jrl

       inGenious Targeting Laboratory - Custom generated mouse model solutions for COPS3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for COPS3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for COPS3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for COPS3 

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    SwitchGear 3'UTR luciferase reporter plasmidCOPS3 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for COPS3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway


    1 BioSystems Pathway for COPS3
        TNF-alpha/NF-kB Signaling Pathway


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for COPS3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/645 Interacting proteins for COPS3 (Q9UNS21, 2, 3 ENSP000002687174) via UniProtKB, MINT, STRING, and/or I2D (see all 645)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARAFP103981, 2, 3, ENSP000003662444EBI-350590,EBI-365961 MINT-19322 I2D: score=6 STRING: ENSP00000366244
    COPS6Q7L5N12, 3, ENSP000003041024MINT-7945693 MINT-7230300 I2D: score=7 STRING: ENSP00000304102
    COPS5Q929052, 3, ENSP000003505124MINT-7945693 MINT-7230300 I2D: score=6 STRING: ENSP00000350512
    COPS4Q9BT782, 3, ENSP000002643894MINT-7230300 I2D: score=5 STRING: ENSP00000264389
    CUL1Q136162, 3, ENSP000003268044MINT-7945693 I2D: score=1 STRING: ENSP00000326804
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0007165signal transduction TAS9535219
    GO:0009416response to light stimulus TAS9535219
    GO:0010388cullin deneddylation IDA19141280

    COPS3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for COPS3 (CSN3)

    Search CenterWatch for drugs/clinical trials and news about COPS3 / CSN3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for COPS3 gene (2 alternative transcripts): 
    NM_001199125.1  NM_003653.3  

    Unigene Cluster for COPS3:

    COP9 signalosome subunit 3
    Hs.6076  [show with all ESTs]
    Unigene Representative Sequence: NM_003653
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000539941(uc010vwv.2) ENST00000486032 ENST00000579716 ENST00000268717(uc002grd.3 uc010vww.2)
    ENST00000578317 ENST00000439936 ENST00000463097 ENST00000471414 ENST00000486810
    ENST00000577210 ENST00000417352 ENST00000584216 ENST00000583160 ENST00000492672
    ENST00000477299 ENST00000577246 ENST00000495640 ENST00000462236
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    Additional mRNA sequence: 

    AF031647.1 AF098109.1 AK297706.1 AK302304.1 AK312476.1 AK316400.1 BC001891.1 

    18 DOTS entries:

    DT.456305  DT.100882887  DT.92445117  DT.92445105  DT.100670512  DT.95147013  DT.100882883  DT.100882889 
    DT.92445111  DT.95147015  DT.97859592  DT.97859593  DT.100037854  DT.100037856  DT.100882888  DT.100882894 
    DT.91704791  DT.99949308 

    24/405 AceView cDNA sequences (see all 405):

    BE018055 AA804364 CA443812 F06022 BQ018146 BE256591 AI198725 AI383606 
    BU188780 AL541424 CA394875 AL554005 CR617410 CR594817 CR608585 CA420829 
    BM451489 BQ434232 AA856730 BU164941 AA554227 BQ222025 BX118608 BU187427 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for COPS3 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a ·
    SP1:                                -     -                             -                                   -                                   -               
    SP2:                                -     -                       -     -                                   -                                                   
    SP3:                                -     -     -     -                 -                                   -                                                   
    SP4:                                      -                             -                                                                                       
    SP5:                                                                                                                                            -               

    ExUns: 14b · 14c · 14d
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for COPS3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    COPS3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACCAGGAGA
    COPS3 Expression
    About this image


    See COPS3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for COPS3

    SOURCE GeneReport for Unigene cluster: Hs.6076

    UniProtKB/Swiss-Prot: CSN3_HUMAN, Q9UNS2
    Tissue specificity: Widely expressed. Expressed at high level in heart and skeletal muscle

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPS3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for COPS3 gene from 9/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cops31 , 5 COP9 (constitutive photomorphogenic) homolog, subunit more1, 5 91.88(n)1
    99.53(a)1
      11 (37.80 cM)5
    265721  NM_011991.11  NP_036121.11 
     598177955 
    chicken
    (Gallus gallus)
    Aves COPS31 COP9 constitutive photomorphogenic homolog subunit more 87.63(n)
    98.58(a)
      416504  NM_001006163.1  NP_001006163.1 
    lizard
    (Anolis carolinensis)
    Reptilia COPS36
    Uncharacterized protein
    88(a)
    1 ↔ 1
    GL343500.1(322136-377369)
    African clawed frog
    (Xenopus laevis)
    Amphibia cops3-prov2 COP9 (constitutive photomorphogenic) homolog, subunit more 82.19(n)    BC044034.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufk59f012 wufk59f01 79.35(n)   335720  BC064288.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CSN31 , 3 COP9 complex homolog subunit 31 51(a)3
    56.16(n)1
    53.79(a)1
      77F13
    403081  NM_079466.21  NP_524190.21 
    worm
    (Caenorhabditis elegans)
    Secernentea csn-36
    COP9 signalosome complex subunit 3
    19(a)
    1 ↔ 1
    IV(194745-202585)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons COP131 COP9 signalosome complex subunit 3 48.76(n)
    39.04(a)
      831275  NM_121429.4  NP_568296.1 
    rice
    (Oryza sativa)
    Liliopsida Os08g01190001 hypothetical protein 52.2(n)
    44.67(a)
      4344535  NM_001067405.1  NP_001060870.1 


    ENSEMBL Gene Tree for COPS3 (if available)
    TreeFam Gene Tree for COPS3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for COPS3 gene

    COPS3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for COPS3
    PGOHUM00000245791


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/809 SNPs in COPS3 are shown (see all 809)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs342011511,2
    C--17149541(+) AAAAA-/AA    
       
    /AAAA
    GGCTG
    2 -- ds50011NA 2
    rs1811504981,2
    --17149561(+) GTGCTC/TGCCTG 2 -- ds50010--------
    rs1175329071,2
    F--17149562(+) TGCTCG/ACCTGT 2 -- ds50011Minor allele frequency- A:0.01EA 120
    rs1394210571,2
    --17149650(+) TGCACC/TGCAGC 2 -- ds50010--------
    rs1180577531,2
    F--17149714(+) CCAATG/AGCATC 2 -- ds50011Minor allele frequency- A:0.01NA 120
    rs768497411,2
    --17149818(+) TTTTTG/TTAAAC 2 -- ds50011Minor allele frequency- T:0.50NA 2
    rs1499733901,2
    --17149819(+) TTTTGG/TAAACA 2 -- ds50010--------
    rs1866494631,2
    --17149856(+) AGGTGA/GTCTGA 2 -- ds50010--------
    rs2004086831,2
    --17149942(+) CTGGC-/CTTT  
            
    CTTTT
    2 -- ut310--------
    rs1905920661,2
    --17150122(+) TGATAC/GAGAAG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for COPS3 (17149938 - 17184617 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for COPS3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833382CNV Loss17160897
    nsv833380CNV Loss17160897
    nsv9499CNV Gain18304495
    nsv469777CNV Complex16826518
    nsv155OTHER Inversion15895083
    nsv499114OTHER Inversion21111241

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604665    OMIM disorders: --

    8 diseases for COPS3:    About MalaCards
    small cell osteogenic sarcoma    smith magenis syndrome    xeroderma pigmentosum    osteosarcoma
    sarcoma    myeloid leukemia    hepatocellular carcinoma    leukemia

    1 disease from the University of Copenhagen DISEASES database for COPS3:
    Osteosarcoma

    COPS3 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for COPS3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 8 17366602 (7)


    Export disorders for COPS3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for COPS3 gene, integrated from 9 sources (see all 88):
    (articles sorted by number of sources associating them with COPS3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Subunit 3 of the COP9 signal transduction complex is conserved from plants to humans and maps within the smith-magenis syndrome critical region in 17p11.2. (PubMed id 10191102)1, 2, 3 Potocki L.... Lupski J.R. (1999)
    2. A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. (PubMed id 9535219)1, 2, 3 Seeger M....Dubiel W. (1998)
    3. Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome. (PubMed id 12220626)1, 2, 9 Hoareau Alves K.... Jalinot P. (2002)
    4. Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. (PubMed id 18850735)1, 2 Fang L.... Huang L. (2008)
    5. Amplification and overexpression of genes in 17p11.2 approximately p12 in osteosarcoma. (PubMed id 15325100)1, 2 Van Dartel M. and Hulsebos T.J.M. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome. (PubMed id 12628923)1, 2 Uhle S....Dubiel W. (2003)
    8. The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. (PubMed id 12732143)1, 2 Groisman R.... Nakatani Y. (2003)
    9. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    10. Amplification and overexpression of COPS3 in osteosarcomas potentially target TP53 for proteasome-mediated degradation. (PubMed id 12917637)1, 2 Henriksen J....Forus A. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8533 HGNC: 2239 AceView: COPS3 Ensembl:ENSG00000141030 euGenes: HUgn8533
    ECgene: COPS3 H-InvDB: COPS3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for COPS3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for COPS3 gene:
    Search GeneIP for patents involving COPS3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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