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Aliases for COPS3 Gene

Aliases for COPS3 Gene

  • COP9 Signalosome Subunit 3 2 3
  • SGN3 3 4 6
  • JAB1-Containing Signalosome Subunit 3 3 4
  • Signalosome Subunit 3 3 4
  • CSN3 3 4
  • COP9 (Constitutive Photomorphogenic, Arabidopsis, Homolog) Subunit 3 2
  • COP9 Constitutive Photomorphogenic Homolog Subunit 3 (Arabidopsis) 2
  • COP9 Constitutive Photomorphogenic Homolog Subunit 3 3
  • COP9 Signalosome Complex Subunit 3 3
  • COP9 Complex Subunit 3 3

External Ids for COPS3 Gene

Summaries for COPS3 Gene

Entrez Gene Summary for COPS3 Gene

  • The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for COPS3 Gene

COPS3 (COP9 Signalosome Subunit 3) is a Protein Coding gene. Among its related pathways are TNF-alpha/NF-kB Signaling Pathway.

UniProtKB/Swiss-Prot for COPS3 Gene

  • Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Gene Wiki entry for COPS3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COPS3 Gene

Genomics for COPS3 Gene

Genomic Location for COPS3 Gene

Start:
17,246,624 bp from pter
End:
17,281,303 bp from pter
Size:
34,680 bases
Orientation:
Minus strand

Genomic View for COPS3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COPS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COPS3 Gene

Regulatory Elements for COPS3 Gene

Proteins for COPS3 Gene

  • Protein details for COPS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNS2-CSN3_HUMAN
    Recommended name:
    COP9 signalosome complex subunit 3
    Protein Accession:
    Q9UNS2
    Secondary Accessions:
    • B2R683
    • B4DY81
    • O43191
    • Q7LDR6

    Protein attributes for COPS3 Gene

    Size:
    423 amino acids
    Molecular mass:
    47873 Da
    Quaternary structure:
    • Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS1, COPS4 and COPS8. Interacts with CK2 and PKD. Interacts with the translation initiation factor EIF3S6 and IKBKG.
    Miscellaneous:
    • Amplified and overexpressed in some osteosarcomas (OS), suggesting that it may participate in TP53 degradation in OS
    SequenceCaution:
    • Sequence=AAC14197.1; Type=Frameshift; Positions=5; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for COPS3 Gene

    Alternative splice isoforms for COPS3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COPS3 Gene

Proteomics data for COPS3 Gene at MOPED

Post-translational modifications for COPS3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys30, Lys125, Lys243, Lys254, Lys281, Lys296, Lys312, Lys366, Lys382, Lys391, and Lys406

No data available for DME Specific Peptides for COPS3 Gene

Domains for COPS3 Gene

Protein Domains for COPS3 Gene

Suggested Antigen Peptide Sequences for COPS3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UNS2

UniProtKB/Swiss-Prot:

CSN3_HUMAN
Domain:
  • Contains 1 PCI domain.:
    • Q9UNS2
Family:
  • Belongs to the CSN3 family.:
    • Q9UNS2
genes like me logo Genes that share domains with COPS3: view

No data available for Gene Families for COPS3 Gene

Function for COPS3 Gene

Molecular function for COPS3 Gene

GENATLAS Biochemistry: COP9 (constitutive photomorphogenic,Arabidopsis) homolog subunit 3,ubiquitously expressed,predominantly in cardiac and skeletal muscle,involved in signal transduction,within the Smith-Magenis critical region
UniProtKB/Swiss-Prot Function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Gene Ontology (GO) - Molecular Function for COPS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11418127
genes like me logo Genes that share ontologies with COPS3: view

Phenotypes for COPS3 Gene

genes like me logo Genes that share phenotypes with COPS3: view

Animal Models for COPS3 Gene

MGI Knock Outs for COPS3:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for COPS3 Gene

Localization for COPS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COPS3 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COPS3 Gene COMPARTMENTS Subcellular localization image for COPS3 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for COPS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0008180 COP9 signalosome IDA 18850735
genes like me logo Genes that share ontologies with COPS3: view

Pathways for COPS3 Gene

genes like me logo Genes that share pathways with COPS3: view

Pathways by source for COPS3 Gene

1 BioSystems pathway for COPS3 Gene

Gene Ontology (GO) - Biological Process for COPS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IBA --
GO:0007165 signal transduction TAS 9535219
GO:0009416 response to light stimulus TAS 9535219
GO:0010388 cullin deneddylation IDA 19141280
genes like me logo Genes that share ontologies with COPS3: view

Transcripts for COPS3 Gene

Unigene Clusters for COPS3 Gene

COP9 signalosome subunit 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COPS3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a ·
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - -
SP5: -
SP6: - -
SP7: - - - - - -
SP8:
SP9: - - -
SP10: -
SP11: - -
SP12:

ExUns: 14b · 14c · 14d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for COPS3 Gene

GeneLoc Exon Structure for
COPS3
ECgene alternative splicing isoforms for
COPS3

Expression for COPS3 Gene

mRNA expression in normal human tissues for COPS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for COPS3 Gene

This gene is overexpressed in Muscle - Skeletal (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COPS3 Gene

SOURCE GeneReport for Unigene cluster for COPS3 Gene Hs.6076

mRNA Expression by UniProt/SwissProt for COPS3 Gene

Q9UNS2-CSN3_HUMAN
Tissue specificity: Widely expressed. Expressed at high level in heart and skeletal muscle.
genes like me logo Genes that share expressions with COPS3: view

Orthologs for COPS3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for COPS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COPS3 35
  • 99.76 (n)
  • 100 (a)
COPS3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia COPS3 35
  • 86.6 (n)
  • 98.11 (a)
COPS3 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COPS3 35
  • 93.7 (n)
  • 99.76 (a)
COPS3 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cops3 35
  • 91.88 (n)
  • 99.53 (a)
Cops3 16
Cops3 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia COPS3 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COPS3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cops3 35
  • 91.25 (n)
  • 99.76 (a)
chicken
(Gallus gallus)
Aves COPS3 35
  • 87.63 (n)
  • 98.58 (a)
COPS3 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COPS3 36
  • 89 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia cops3-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cops3 35
  • 82.27 (n)
  • 94.8 (a)
Str.11176 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.684 35
zebrafish
(Danio rerio)
Actinopterygii cops3 35
  • 78.41 (n)
  • 93.38 (a)
cops3 36
  • 95 (a)
OneToOne
wufk59f01 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006445 35
  • 57.29 (n)
  • 56.26 (a)
fruit fly
(Drosophila melanogaster)
Insecta CSN3 35
  • 56.24 (n)
  • 53.79 (a)
CSN3 36
  • 51 (a)
OneToOne
CSN3 37
  • 51 (a)
worm
(Caenorhabditis elegans)
Secernentea csn-3 36
  • 19 (a)
OneToOne
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7012 35
thale cress
(Arabidopsis thaliana)
eudicotyledons COP13 35
  • 48.92 (n)
  • 39.04 (a)
rice
(Oryza sativa)
Liliopsida Os08g0119000 35
  • 52.45 (n)
  • 44.67 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.2898 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1915 35
Species with no ortholog for COPS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for COPS3 Gene

ENSEMBL:
Gene Tree for COPS3 (if available)
TreeFam:
Gene Tree for COPS3 (if available)

Paralogs for COPS3 Gene

Pseudogenes.org Pseudogenes for COPS3 Gene

genes like me logo Genes that share paralogs with COPS3: view

No data available for Paralogs for COPS3 Gene

Variants for COPS3 Gene

Sequence variations from dbSNP and Humsavar for COPS3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs8511 -- 17,247,077(-) TGAGC(G/T)AAACA utr-variant-3-prime
rs15316 -- 17,262,020(-) CTTGG(A/C)AAAGT synonymous-codon, reference
rs1029829 -- 17,280,766(+) GCGGT(C/G)CGCCA upstream-variant-2KB, intron-variant
rs1029830 -- 17,280,783(+) GAAGG(A/C)AAGAG upstream-variant-2KB, intron-variant
rs1029832 -- 17,281,431(+) CACTT(C/G)TGAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for COPS3 Gene

Variant ID Type Subtype PubMed ID
nsv155 OTHER Inversion 15895083
nsv499114 OTHER Inversion 21111241
nsv833380 CNV Loss 17160897
nsv833382 CNV Loss 17160897
nsv469777 CNV Complex 16826518
nsv9499 CNV Gain 18304495

Relevant External Links for COPS3 Gene

HapMap Linkage Disequilibrium report
COPS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COPS3 Gene

Disorders for COPS3 Gene

(1) University of Copenhagen DISEASES for COPS3 Gene

(1) Novoseek inferred disease relationships for COPS3 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 7
genes like me logo Genes that share disorders with COPS3: view

No data available for UniProtKB/Swiss-Prot for COPS3 Gene

Publications for COPS3 Gene

  1. Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome. (PMID: 12220626) Hoareau Alves K. … Jalinot P. (FEBS Lett. 2002) 3 4 23
  2. Subunit 3 of the COP9 signal transduction complex is conserved from plants to humans and maps within the Smith-Magenis syndrome critical region in 17p11.2. (PMID: 10191102) Potocki L. … Lupski J.R. (Genomics 1999) 2 3 4
  3. A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. (PMID: 9535219) Seeger M. … Dubiel W. (FASEB J. 1998) 2 3 4
  4. Amplification and overexpression of genes in 17p11.2 approximately p12 in osteosarcoma. (PMID: 15325100) Van Dartel M. … Hulsebos T.J.M. (Cancer Genet. Cytogenet. 2004) 3 4
  5. Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome. (PMID: 12628923) Uhle S. … Dubiel W. (EMBO J. 2003) 3 4

Products for COPS3 Gene

Sources for COPS3 Gene

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