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GIFtS

COPS2 Gene

protein-coding   GIFtS: 51
GCID: GC15M049417

COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)
 Explore 15 diseases affiliated with
COPS2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for COPS2    

Aliases
for COPS2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
COP9 Constitutive Photomorphogenic Homolog Subunit 2 (Arabidopsis)1 2     Thyroid Receptor-Interacting Protein 152 3
TRIP151 2 3 5     TRIP-152 3
CSN21 2 3     JAB1-Containing Signalosome Subunit 22 3
SGN22 3 5     TR-Interacting Protein 152 3
ALIEN1 2     COP9 Signalosome Complex Subunit 22
Alien Homolog2 3     Thyroid Receptor Interacting Protein 152
Signalosome Subunit 22 3     

External Ids:    HGNC: 307471   Entrez Gene: 93182   Ensembl: ENSG000001662007   OMIM: 6045085   UniProtKB: P612013   

Export aliases for COPS2 gene to outside databases

Previous GC identifers: GC00U920616 GC15M047207 GC15M026249


Summaries
for COPS2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: CSN2_HUMAN, P61201
Function: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and
developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by
mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase
activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53,
c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases.
CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Involved in early stage of neuronal differentiation via its interaction with NIF3L1

Gene Wiki entry for COPS2


Genomic Views
for COPS2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the COPS2 gene promoter:
         SRF   STAT1   SREBP-1c   SRF (504 AA)   SREBP-1b   Evi-1   GATA-1   SREBP-1a   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: COPS2 promoter sequence
   Search SABiosciences Chromatin IP Primers for COPS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COPS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.2   Ensembl cytogenetic band:  15q21.1   HGNC cytogenetic band: 15q21.2

COPS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COPS2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M049417:  view genomic region     (about GC identifiers)

Start:
 49,398,268 bp from pter      End:
 49,447,858 bp from pter
Size:
 49,591 bases      Orientation:
 minus strand

Proteins
for COPS2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CSN2_HUMAN, P61201 (See protein sequence)
Recommended Name: COP9 signalosome complex subunit 2  
Size: 443 amino acids; 51597 Da
Subunit: Interacts with NIF3L1 (By similarity). Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3,
COPS4, COPS5, COP6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS1,
COPS4, COPS5 COPS6 and COPS7 (COPS7A or COPS7B). Interacts with CUL1 and CUL2. Specifically interacts with the ligand
binding domain of the thyroid receptor (TR). Does not require the presence of thyroid hormone for its interaction.
Interacts with IRF8/ICSBP1 and with nuclear receptors NR2F1 and NR0B1
Subcellular location: Cytoplasm. Nucleus
Sequence caution: Sequence=AAD30269.1; Type=Frameshift; Positions=304;
Secondary accessions: O88950 Q15647 Q6FGP4 Q9BY54 Q9R249 Q9UNI2 Q9UNQ5
Alternative splicing: 2 isoforms:  P61201-1   P61201-2   

Explore the universe of human proteins at neXtProt for COPS2: NX_P61201

Post-translational modifications:

  • Phosphorylated by CK2 and PKD kinases1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P61201

    • COPS2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001137359.1  NP_004227.1  

    ENSEMBL proteins: 
     ENSP00000453546   ENSP00000373553   ENSP00000299259   ENSP00000443664   ENSP00000452944  
     ENSP00000453412  

    Human Recombinant Protein Products: 
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    OriGene Purified Protein: COPS2
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    Novus Biologicals COPS2 Proteins
    Novus Biologicals COPS2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for COPS2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm IDA9535219
    GO:0008180signalosome IDA18850735


    COPS2 for ontologies           About GeneDecksing



    COPS2 Antibody Products: 
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    Uscn Antibodies for COPS2
    ThermoFisher Antibodies for COPS2

    Assay Products for COPS2: 
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    Uscn ELISAs and CLIAs for COPS2

    Protein Domains /
    Families
    for COPS2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    COPS2 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR019280 COP9_signalosome_subunit_CSN8
     IPR011990 TPR-like_helical
     IPR013143 PAM
     IPR000717 PCI_dom
     IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom

    Graphical View of Domain Structure for InterPro Entry P61201

    ProtoNet protein and cluster: P61201

    UniProtKB/Swiss-Prot: CSN2_HUMAN, P61201
    Similarity: Belongs to the CSN2 family
    Similarity: Contains 1 PCI domain


    Function
    for COPS2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CSN2_HUMAN, P61201
    Function: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and
    developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by
    mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase
    activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53,
    c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases.
    CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
    Involved in early stage of neuronal differentiation via its interaction with NIF3L1

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COPS2
    8/142 QIAGEN miScript miRNA Assays for microRNAs that regulate COPS2 (see all 142):
    hsa-miR-124* hsa-miR-100* hsa-miR-3938 hsa-miR-199a-3p hsa-miR-605 hsa-miR-3074-3p hsa-miR-3170 hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmid: COPS2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COPS2 (see all 7)
    OriGene shRNA RFP: COPS2
    OriGene siRNA: COPS2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COPS2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for COPS2

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COPS2 (see all 5)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COPS2 

    Cell Line
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    Search LifeMap BioReagents cell lines for COPS2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPS2

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714transcription corepressor activity IEA--
    GO:0004871signal transducer activity NAS9535219
    GO:0005515protein binding IPI17438371
    GO:0016564transcription repressor activity ----


    COPS2 for ontologies           About GeneDecksing


    6 GenomeRNAi human phenotypes for COPS2:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Decreased circadian period len 
     Increased cell death in HCT116  Synthetic lethal with Ras 

    Animal Models:
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cops2):
     cellular  embryogenesis  mortality/aging 

    COPS2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for COPS2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for COPS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/79 Interacting proteins for COPS2 (P612012, 3 ENSP000002992594) via UniProtKB, MINT, STRING, and/or I2D (see all 79)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GFERP557892, 3, ENSP000002481144MINT-50629 MINT-50729 MINT-50639 MINT-50630 MINT-50634 I2D: score=2 STRING: ENSP00000248114
    NFKBIAP259632, 3, ENSP000002167974MINT-4544626 I2D: score=1 STRING: ENSP00000216797
    CREBBPQ927932MINT-8414892 MINT-8414960 MINT-8414946
    COPS5Q929053, ENSP000003505124I2D: score=6 STRING: ENSP00000350512
    COPS3Q9UNS23, ENSP000002687174I2D: score=5 STRING: ENSP00000268717
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006366transcription from RNA polymerase II promoter TAS7776974
    GO:0007165signal transduction NAS9535219
    GO:0008283cell proliferation IEA--
    GO:0010388cullin deneddylation IDA19141280


    COPS2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for COPS2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    COPS2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for COPS2
    1 Novoseek chemical compound relationship for COPS2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 28.3 2 10713076 (1), 10961925 (1)

    Search CenterWatch for drugs/clinical trials and news about COPS2 / CSN2 

    Transcripts
    for COPS2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for COPS2 gene (2 alternative transcripts): 
    NM_001143887.1  NM_004236.3  

    Unigene Cluster for COPS2:

    COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)
    Hs.369614  [show with all ESTs]
    Unigene Representative Sequence: NM_001143887
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000560240 ENST00000388901(uc001zxf.3 uc001zxh.3 uc010ufa.2)
    ENST00000299259 ENST00000542928 ENST00000558843 ENST00000561248 ENST00000559016
    ENST00000558545

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): COPS2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COPS2
    8/142 QIAGEN miScript miRNA Assays for microRNAs that regulate COPS2 (see all 142):
    hsa-miR-124* hsa-miR-100* hsa-miR-3938 hsa-miR-199a-3p hsa-miR-605 hsa-miR-3074-3p hsa-miR-3170 hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmid: COPS2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COPS2 (see all 7)
    OriGene shRNA RFP: COPS2
    OriGene siRNA: COPS2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COPS2
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COPS2 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COPS2 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): COPS2 (NM_004236)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COPS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COPS2 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat COPS2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COPS2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COPS2

    Additional cDNA sequence: 

    AB209799.1 AF084260.1 AF100762.1 AF120268.1 AF212227.1 AK222590.1 AK295598.1 AK312643.1 
    BC012629.1 BX648602.1 CR542063.1 L40388.1 

    17 DOTS entries:

    DT.101977013  DT.453520  DT.95071757  DT.95071756  DT.100823423  DT.100823421  DT.97851258  DT.100823432 
    DT.95170275  DT.100694375  DT.100823428  DT.100718218  DT.100840321  DT.121049829  DT.92440049  DT.97763265 
    DT.100775545 

    24/318 AceView cDNA sequences (see all 318):

    AI151426 AA131420 BM667648 AA262487 AI082435 BQ929590 N32342 BP342227 
    AI332898 AA278852 BQ376874 AI433799 AA318732 AA293407 BU155128 AI192408 
    CB267405 BM128198 AU098427 BM716663 CR614722 AI038565 AI761477 AI469077 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for COPS2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
    SP1:                                      -     -                       -                                             
    SP2:                                      -                             -                                             
    SP3:                                                                                                                  
    SP4:                                                                                                                  


    ECgene alternative splicing isoforms for COPS2

    Expression
    for COPS2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    COPS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATAAATTAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    COPS2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbLimb BudLimb Bud Mesenchyme CellsMesoderm
    LimbZeugopodMesenchymal Condensate CellsBone, Cartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See COPS2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for COPS2

    SOURCE GeneReport for Unigene cluster: Hs.369614
        SABiosciences Expression via Pathway-Focused PCR Array including COPS2: 
              Nuclear Receptors & Coregulators in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COPS2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPS2

    Orthologs
    for COPS2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for COPS2 gene from 9/35 species (see all 35)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cops21 , 5 COP9 (constitutive photomorphogenic) homolog, subunit more1, 5 94.51(n)1
    100(a)1    		   2 (61.76 cM)5
    128481  NM_009939.21  NP_034069.21 
     1258303045 
    chicken
    (Gallus gallus)    		 Aves COPS21 COP9 constitutive photomorphogenic homolog subunit more 90.82(n)
    99.77(a)    		   430917  NM_001031596.1  NP_001026767.1 
    lizard
    (Anolis carolinensis)    		 Reptilia COPS26
    		 --
    		 94(a)
    		 1 ↔ 1
    		 GL343506.1(263727-270447)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BX847537.12   -- 86.4(n)    BX847537.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii cops21 COP9 constitutive photomorphogenic homolog subunit more 81.34(n)
    99.32(a)    		   415145  NM_001002055.1  NP_001002055.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta alien1 CG9556-PA 72.23(n)
    83.97(a)    		   34225  NM_078793.5  NP_523517.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea csn-21 Protein CSN-2 65.21(n)
    66.99(a)    		   172278  NM_059339.5  NP_491740.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons FUS121 COP9 signalosome complex subunit 2 62.26(n)
    61.48(a)    		   817241  NM_128257.3  NP_565632.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.259642 Oryza sativa (japonica cultivar-group) cDNA clone0 more 78.11(n)    AK103258.1 


    ENSEMBL Gene Tree for COPS2 (if available)
    TreeFam Gene Tree for COPS2 (if available) 

    Paralogs
    for COPS2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for COPS2 gene
    PSMD112  

    COPS2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for COPS2
    PGOHUM00000236329


    Genomic Variants
    for COPS2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/442 NCBI SNPs in COPS2 are shown (see all 442)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs343152471,2
    		C--26271996(+) ACTCC-/AAAAAA 1 -- int11Minor allele frequency- A:0.00NA 2
    rs340537241,2
    		C,F,--49417084(+) TCCACT/CAGGCA 2 -- int13Minor allele frequency- C:0.33NA 6
    rs1406876541,2
    		--49417342(+) TAGGCA/CTCACT 2 -- int10--------
    rs1830510021,2
    		--49417361(+) AGGTTC/TTCAGT 2 -- int10--------
    rs1457846341,2
    		--49417380(+) AAGATG/TTATCA 2 -- int10--------
    rs1861566691,2
    		--49417464(+) AGTTAC/TGTTAC 2 -- int10--------
    rs1901346411,2
    		--49417469(+) TGTTAC/TATTAA 2 -- spd10--------
    rs10489751,2
    		C,F,O,A,H,--49417546(-) ACTACC/AAGAGC 2 -- ut3125Minor allele frequency- A:0.44MN NA NS EA WA CSA 2664
    rs1827573871,2
    		--49417591(+) TTGCAA/GTAACT 2 -- ut310--------
    rs727272171,2
    		C,F,--49417705(+) GAATAA/CATGCT 2 -- ut311Minor allele frequency- C:0.02EA 120

    HapMap Linkage Disequilibrium report for COPS2 (49398268 - 49447858 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for COPS2: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COPS2
    DNA2.0 Custom Variant and Variant Library Synthesis for COPS2

    Disorders / Diseases
    for COPS2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    COPS2 for disorders           About GeneDecksing

    OMIM gene information: 604508    OMIM disorders: --

    15 diseases for COPS2:    About MalaCards
    epilepsia partialis continua    facial hemiatrophy    anterior cerebral artery infarction    thyroiditis
    adrenal hypoplasia    cerebrovascular accident    dysgraphia    dyscalculia
    aphasia    apraxia    cerebritis    prostate cancer
    prostatitis    malaria    neuronitis

    6 diseases from the University of Copenhagen DISEASES database for COPS2:
    Ideomotor apraxia     Tactile agnosia     Dysgraphia     Apraxia
    Facial hemiatrophy     Dyscalculia

    Export disorders for COPS2 gene to outside databases

    Publications
    for COPS2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for COPS2 gene, integrated from 9 sources (see all 80):
    (articles sorted by number of sources associating them with COPS2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. (PubMed id 9535219)1, 2, 3, 9 Seeger M....Dubiel W. (1998)
    2. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. (PubMed id 7776974)1, 2, 3 Lee J.W....Moore D.D. (1995)
    3. Interaction of the corepressor Alien with DAX-1 is abrogated by mutations of DAX-1 involved in adrenal hypoplasia congenita. (PubMed id 10713076)1, 2, 9 Altincicek B....Baniahmad A. (2000)
    4. Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome. (PubMed id 12628923)1, 2, 9 Uhle S....Dubiel W. (2003)
    5. Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. (PubMed id 18850735)1, 2 Fang L.... Huang L. (2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. (PubMed id 12732143)1, 2 Groisman R.... Nakatani Y. (2003)
    8. COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system. (PubMed id 11285227)1, 2 Bech-Otschir D.... Dubiel W. (2001)
    9. Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. (PubMed id 11337588)1, 2 Lyapina S.... Deshaies R.J. (2001)
    10. Interaction between interferon consensus sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9/signalosome. (PubMed id 10991940)1, 2 Cohen H.... Levi B.Z. (2000)

    External Searches for COPS2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing COPS2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9318 HGNC: 30747 AceView: TRIP15 Ensembl:ENSG00000166200 euGenes: HUgn9318
    ECgene: COPS2 H-InvDB: COPS2

    Other Databases showing COPS2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing COPS2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for COPS2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for COPS2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for COPS2 gene:
    Search GeneIP for patents involving COPS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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