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COPS2 Gene

protein-coding   GIFtS: 55
GCID: GC15M049417

COP9 Signalosome Subunit 2

(Previous name: COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
COP9 Signalosome Subunit 21 2     JAB1-Containing Signalosome Subunit 22 3
SGN22 3 5     TR-Interacting Protein 152 3
TRIP152 3 5     COP9 Constitutive Photomorphogenic Homolog Subunit 2 (Arabidopsis)1
Alien Homolog2 3     ALIEN2
Signalosome Subunit 22 3     COP9 Constitutive Photomorphogenic Homolog Subunit 22
Thyroid Receptor-Interacting Protein 152 3     COP9 Signalosome Complex Subunit 22
CSN22 3     Thyroid Receptor Interacting Protein 152
TRIP-152 3     

External Ids:    HGNC: 307471   Entrez Gene: 93182   Ensembl: ENSG000001662007   OMIM: 6045085   UniProtKB: P612013   

Export aliases for COPS2 gene to outside databases

Previous GC identifers: GC00U920616 GC15M047207 GC15M026249


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for COPS2 Gene:
COPS2 (COP9 signalosome subunit 2) is a protein-coding gene. Diseases associated with COPS2 include anterior cerebral artery infarction, and facial hemiatrophy. GO annotations related to this gene include transcription corepressor activity and signal transducer activity. An important paralog of this gene is PSMD11.

UniProtKB/Swiss-Prot: CSN2_HUMAN, P61201
Function: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and
developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by
mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl
ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation
of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD
kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system,
respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1

Gene Wiki entry for COPS2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the COPS2 gene promoter:
         SRF   STAT1   SREBP-1c   SRF (504 AA)   SREBP-1b   Evi-1   GATA-1   SREBP-1a   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOPS2 promoter sequence
   Search Chromatin IP Primers for COPS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COPS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.2   Ensembl cytogenetic band:  15q21.1   HGNC cytogenetic band: 15q21.2

COPS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COPS2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M049417:  view genomic region     (about GC identifiers)

Start:
49,398,268 bp from pter      End:
49,447,858 bp from pter
Size:
49,591 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CSN2_HUMAN, P61201 (See protein sequence)
Recommended Name: COP9 signalosome complex subunit 2  
Size: 443 amino acids; 51597 Da
Subunit: Interacts with NIF3L1 (By similarity). Component of the CSN complex, composed of COPS1/GPS1, COPS2,
COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly
with COPS1, COPS4, COPS5 COPS6 and COPS7 (COPS7A or COPS7B). Interacts with CUL1 and CUL2. Specifically interacts
with the ligand binding domain of the thyroid receptor (TR). Does not require the presence of thyroid hormone for
its interaction. Interacts with IRF8/ICSBP1 and with nuclear receptors NR2F1 and NR0B1
Sequence caution: Sequence=AAD30269.1; Type=Frameshift; Positions=304;
Secondary accessions: O88950 Q15647 Q6FGP4 Q9BY54 Q9R249 Q9UNI2 Q9UNQ5
Alternative splicing: 2 isoforms:  P61201-1   P61201-2   

Explore the universe of human proteins at neXtProt for COPS2: NX_P61201

Explore proteomics data for COPS2 at MOPED

Post-translational modifications: 

  • Phosphorylated by CK2 and PKD kinases1
  • Ubiquitination2 at Lys331, Lys415, Lys426, Lys441
  • Modification sites at PhosphoSitePlus

  • See COPS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001137359.1  NP_004227.1  

    ENSEMBL proteins: 
     ENSP00000453546   ENSP00000373553   ENSP00000299259   ENSP00000443664   ENSP00000452944  
     ENSP00000453412  

    COPS2 Human Recombinant Protein Products:

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    Novus Biologicals COPS2 Proteins
    Novus Biologicals COPS2 Lysate
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    Cloud-Clone Corp. Proteins for COPS2

    COPS2 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for COPS2

    COPS2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for COPS2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for COPS2
    Cloud-Clone Corp. CLIAs for COPS2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR013143 PAM
     IPR000717 PCI_dom
     IPR011991 WHTH_DNA-bd_dom

    Graphical View of Domain Structure for InterPro Entry P61201

    ProtoNet protein and cluster: P61201

    UniProtKB/Swiss-Prot: CSN2_HUMAN, P61201
    Similarity: Belongs to the CSN2 family
    Similarity: Contains 1 PCI domain


    COPS2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CSN2_HUMAN, P61201
    Function: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and
    developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by
    mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl
    ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation
    of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD
    kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system,
    respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714transcription corepressor activity IEA--
    GO:0004871signal transducer activity NAS9535219
    GO:0005515protein binding IPI17438371
         
    COPS2 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for COPS2:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Decreased circadian period len 
     Increased cell death in HCT116  Synthetic lethal with Ras 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cops2):
     cellular  embryogenesis  mortality/aging  reproductive system 

    COPS2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for COPS2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for COPS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for COPS2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for COPS2

    miRNA
    Products:
        
    miRTarBase miRNAs that target COPS2:
    hsa-let-7b-5p (MIRT032402), hsa-mir-181a-5p (MIRT025181)

    Block miRNA regulation of human, mouse, rat COPS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate COPS2 (see all 142):
    hsa-miR-124* hsa-miR-100* hsa-miR-3938 hsa-miR-199a-3p hsa-miR-605 hsa-miR-3074-3p hsa-miR-3170 hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidCOPS2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for COPS2
    Predesigned siRNA for gene silencing in human, mouse, rat COPS2

    Gene Editing
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): COPS2 (NM_004236)
    Sino Biological Human cDNA Clone for COPS2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COPS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COPS2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for COPS2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPS2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CSN2_HUMAN, P61201: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    golgi apparatus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm IDA9535219
    GO:0008180COP9 signalosome IDA18850735

    COPS2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for COPS2
        Prolactin Signaling



        Pathway & Disease-focused RT2 Profiler PCR Array including COPS2: 
              Nuclear Receptors & Coregulators in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for COPS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for COPS2 (P612011, 2, 3 ENSP000002992594) via UniProtKB, MINT, STRING, and/or I2D (see all 122)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GFERP557892, 3, ENSP000002481144MINT-50629 MINT-50729 MINT-50639 MINT-50630 MINT-50634 I2D: score=2 STRING: ENSP00000248114
    CREBBPQ927931, 2EBI-1050386,EBI-81215 MINT-8414892 MINT-8414960 MINT-8414946
    EP300Q094721, 2EBI-1050386,EBI-447295 MINT-8414246 MINT-8414816
    NFKBIAP259632, 3, ENSP000002167974MINT-4544626 I2D: score=1 STRING: ENSP00000216797
    COPS5Q929053, ENSP000003505124I2D: score=6 STRING: ENSP00000350512
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006366transcription from RNA polymerase II promoter TAS7776974
    GO:0007165signal transduction NAS9535219
    GO:0008283cell proliferation IEA--
    GO:0010388cullin deneddylation IDA19141280

    COPS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for COPS2 (CSN2)

    1 Novoseek inferred chemical compound relationship for COPS2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 28.3 2 10713076 (1), 10961925 (1)



    COPS2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for COPS2 gene (2 alternative transcripts): 
    NM_001143887.1  NM_004236.3  

    Unigene Cluster for COPS2:

    COP9 signalosome subunit 2
    Hs.369614  [show with all ESTs]
    Unigene Representative Sequence: NM_001143887
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000560240 ENST00000388901(uc001zxf.3 uc001zxh.3 uc010ufa.2)
    ENST00000299259 ENST00000542928 ENST00000558843 ENST00000561248 ENST00000559016
    ENST00000558545
    miRNA
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    Block miRNA regulation of human, mouse, rat COPS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate COPS2 (see all 142):
    hsa-miR-124* hsa-miR-100* hsa-miR-3938 hsa-miR-199a-3p hsa-miR-605 hsa-miR-3074-3p hsa-miR-3170 hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidCOPS2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for COPS2
    Predesigned siRNA for gene silencing in human, mouse, rat COPS2
    Clone
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    OriGene clones in human, mouse for COPS2 (see all 13)
    OriGene ORF clones in mouse, rat for COPS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): COPS2 (NM_004236)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COPS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COPS2
    Primer
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    OriGene qPCR primer pairs and template standards for COPS2
    OriGene qSTAR qPCR primer pairs in human, mouse for COPS2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat COPS2
      QuantiTect SYBR Green Assays in human, mouse, rat COPS2
      QuantiFast Probe-based Assays in human, mouse, rat COPS2

    Additional mRNA sequence: 

    AB209799.1 AF084260.1 AF100762.1 AF120268.1 AF212227.1 AK222590.1 AK295598.1 AK312643.1 
    BC012629.1 BX648602.1 CR542063.1 L40388.1 

    17 DOTS entries:

    DT.101977013  DT.453520  DT.95071757  DT.95071756  DT.100823423  DT.100823421  DT.97851258  DT.100823432 
    DT.95170275  DT.100694375  DT.100823428  DT.100718218  DT.100840321  DT.121049829  DT.92440049  DT.97763265 
    DT.100775545 

    Selected AceView cDNA sequences (see all 318):

    L40388 AL121486 AA827045 CA423904 AI263895 BE328327 AA491048 AW134885 
    AW955544 AI653444 CA448148 BP342227 BM849445 T31020 AA059260 W39496 
    AW674773 AI758274 N32342 BM692988 BM698713 AI332898 BC012629 BU155225 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for COPS2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
    SP1:                                      -     -                       -                                             
    SP2:                                      -                             -                                             
    SP3:                                                                                                                  
    SP4:                                                                                                                  


    ECgene alternative splicing isoforms for COPS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    COPS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATAAATTAA
    COPS2 Expression
    About this image


    COPS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
             Bone Marrow
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
     
     Mesoderm (Gastrulation Derivatives)
             Limb Bud Mesenchyme Cells Limb Bud
    COPS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    COPS2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.369614
        Pathway & Disease-focused RT2 Profiler PCR Array including COPS2: 
              Nuclear Receptors & Coregulators in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for COPS2
    OriGene qSTAR qPCR primer pairs in human, mouse for COPS2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat COPS2
    QuantiTect SYBR Green Assays in human, mouse, rat COPS2
    QuantiFast Probe-based Assays in human, mouse, rat COPS2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for COPS2 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cops25 COP9 (constitutive photomorphogenic) homolog, subunit more   --   2 (61.76 cM) 125830304 
    chicken
    (Gallus gallus)
    Aves COPS26
    Gallus gallus COP9 constitutive photomorphogenic h...
    100(a)
    1 ↔ 1
    10(9932685-9953887)
    lizard
    (Anolis carolinensis)
    Reptilia COPS26
    COP9 signalosome subunit 2
    84(a)
    1 ↔ 1
    GL343506.1(257271-275837)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX847537.12   -- 86.4(n)    BX847537.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cops26
    COP9 constitutive photomorphogenic homolog subunit...
    99(a)
    1 ↔ 1
    25(33344712-33360304) ENSDARG00000004785
    fruit fly
    (Drosophila melanogaster)
    Insecta alien6
    alien
    83(a)
    1 ↔ 1
    2L(8993818-8997379)
    worm
    (Caenorhabditis elegans)
    Secernentea csn-26
    Protein CSN-2 (csn-2) mRNA, complete cds
    56(a)
    1 ↔ 1
    I(6022660-6026981) WBGene00000814
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPN66
    Essential, non-ATPase regulatory subunit of the 26...
    19(a)
    1 → many
    IV(285391-286695) YDL097C
    soybean
    (Glycine max)
    eudicotyledons Gma.102292 Transcribed sequence with moderate similarity to protein more 75.47(n)  
    rice
    (Oryza sativa)
    Liliopsida Os.259642 Oryza sativa (japonica cultivar-group) cDNA clone0 more 78.11(n)    AK103258.1 


    ENSEMBL Gene Tree for COPS2 (if available)
    TreeFam Gene Tree for COPS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for COPS2 gene
    PSMD112  

    COPS2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for COPS2
    PGOHUM00000236329


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for COPS2 (see all 532)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs340537241,2
    C,F--49417084(+) TCCACT/CAGGCA 2 -- int13Minor allele frequency- C:0.33NA 6
    rs1406876541,2
    C--49417342(+) TAGGCA/C/TTCACT 2 -- int10--------
    rs1830510021,2
    --49417361(+) AGGTTC/TTCAGT 2 -- int10--------
    rs1457846341,2
    --49417380(+) AAGATG/TTATCA 2 -- int10--------
    rs1861566691,2
    --49417464(+) AGTTAC/TGTTAC 2 -- int10--------
    rs1901346411,2
    --49417469(+) TGTTAC/TATTAA 2 -- spd10--------
    rs10489751,2
    C,F,O,A,H--49417546(-) ACTACC/AAGAGC 2 -- ut3125Minor allele frequency- A:0.44MN NA NS EA WA CSA 2664
    rs1827573871,2
    --49417591(+) TTGCAA/GTAACT 2 -- ut310--------
    rs727272171,2
    C,F--49417705(+) GAATAA/CATGCT 2 -- ut311Minor allele frequency- C:0.02EA 120
    rs1384949341,2
    --49417746(+) CTAAAG/TTTATA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for COPS2 (49398268 - 49447858 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for COPS2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv827332CNV Loss20364138

    Human Gene Mutation Database (HGMD): COPS2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing COPS2
    DNA2.0 Custom Variant and Variant Library Synthesis for COPS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604508    OMIM disorders: --

    15 diseases for COPS2:    
    About MalaCards
    anterior cerebral artery infarction    facial hemiatrophy    tactile agnosia    dyscalculia
    dysgraphia    agnosia    apraxia    aphasia
    thyroiditis    xeroderma pigmentosum    cerebritis    prostate cancer
    prostatitis    malaria    neuronitis

    5 diseases from the University of Copenhagen DISEASES database for COPS2:
    Ideomotor apraxia     Tactile agnosia     Facial hemiatrophy     Apraxia
    Dysgraphia

    COPS2 for disorders           About GeneDecksing


    Export disorders for COPS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for COPS2 gene, integrated from 10 sources (see all 86):
    (articles sorted by number of sources associating them with COPS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. (PubMed id 9535219)1, 2, 3, 9 Seeger M.... Dubiel W. (FASEB J. 1998)
    2. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. (PubMed id 7776974)1, 2, 3 Lee J.W.... Moore D.D. (Mol. Endocrinol. 1995)
    3. Interaction of the corepressor Alien with DAX-1 is abrogated by mutations of DAX-1 involved in adrenal hypoplasia congenita. (PubMed id 10713076)1, 2, 9 Altincicek B....Baniahmad A. (J. Biol. Chem. 2000)
    4. Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome. (PubMed id 12628923)1, 2, 9 Uhle S....Dubiel W. (EMBO J. 2003)
    5. Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. (PubMed id 18850735)1, 2 Fang L.... Huang L. (J. Proteome Res. 2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. (PubMed id 12732143)1, 2 Groisman R.... Nakatani Y. (Cell 2003)
    8. COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system. (PubMed id 11285227)1, 2 Bech-Otschir D.... Dubiel W. (EMBO J. 2001)
    9. Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. (PubMed id 11337588)1, 2 Lyapina S.... Deshaies R.J. (Science 2001)
    10. Interaction between interferon consensus sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9/signalosome. (PubMed id 10991940)1, 2 Cohen H.... Levi B.Z. (J. Biol. Chem. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9318 HGNC: 30747 AceView: TRIP15 Ensembl:ENSG00000166200 euGenes: HUgn9318
    ECgene: COPS2 H-InvDB: COPS2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for COPS2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for COPS2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for COPS2 gene:
    Search GeneIP for patents involving COPS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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