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Aliases for COPS2 Gene

Aliases for COPS2 Gene

  • COP9 Signalosome Subunit 2 2 3
  • TRIP15 3 4 6
  • Thyroid Receptor-Interacting Protein 15 3 4
  • JAB1-Containing Signalosome Subunit 2 3 4
  • TR-Interacting Protein 15 3 4
  • Signalosome Subunit 2 3 4
  • Alien Homolog 3 4
  • TRIP-15 3 4
  • SGN2 3 4
  • CSN2 3 4
  • COP9 Constitutive Photomorphogenic Homolog Subunit 2 (Arabidopsis) 2
  • COP9 Constitutive Photomorphogenic Homolog Subunit 2 3
  • Thyroid Receptor Interacting Protein 15 3
  • COP9 Signalosome Complex Subunit 2 3
  • ALIEN 3
  • SGN2, 6

External Ids for COPS2 Gene

Summaries for COPS2 Gene

GeneCards Summary for COPS2 Gene

COPS2 (COP9 Signalosome Subunit 2) is a Protein Coding gene. Diseases associated with COPS2 include dysgraphia and ideomotor apraxia. Among its related pathways are PI-3K cascade and Signaling by GPCR. GO annotations related to this gene include signal transducer activity and transcription corepressor activity. An important paralog of this gene is PSMD11.

UniProtKB/Swiss-Prot for COPS2 Gene

  • Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.

Gene Wiki entry for COPS2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COPS2 Gene

Genomics for COPS2 Gene

Genomic Location for COPS2 Gene

Start:
49,106,068 bp from pter
End:
49,155,661 bp from pter
Size:
49,594 bases
Orientation:
Minus strand

Genomic View for COPS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COPS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COPS2 Gene

Regulatory Elements for COPS2 Gene

Proteins for COPS2 Gene

  • Protein details for COPS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61201-CSN2_HUMAN
    Recommended name:
    COP9 signalosome complex subunit 2
    Protein Accession:
    P61201
    Secondary Accessions:
    • O88950
    • Q15647
    • Q6FGP4
    • Q9BY54
    • Q9R249
    • Q9UNI2
    • Q9UNQ5

    Protein attributes for COPS2 Gene

    Size:
    443 amino acids
    Molecular mass:
    51597 Da
    Quaternary structure:
    • Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS1, COPS4, COPS5, COPS6 and COPS7 (COPS7A or COPS7B) (PubMed:11337588, PubMed:18850735). Specifically interacts with the ligand binding domain of the thyroid receptor (TR). Does not require the presence of thyroid hormone for its interaction (By similarity). Interacts with CUL1 and CUL2 (PubMed:11337588). Interacts with IRF8/ICSBP1 and with nuclear receptors NR2F1 and NR0B1 (PubMed:10207062, PubMed:10713076, PubMed:10991940). Interacts with NIF3L1 (By similarity).
    SequenceCaution:
    • Sequence=AAD30269.1; Type=Frameshift; Positions=304; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for COPS2 Gene

    Alternative splice isoforms for COPS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COPS2 Gene

Proteomics data for COPS2 Gene at MOPED

Post-translational modifications for COPS2 Gene

  • Phosphorylated by CK2 and PKD kinases.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys331, Lys415, Lys426, and Lys441

Other Protein References for COPS2 Gene

No data available for DME Specific Peptides for COPS2 Gene

Domains for COPS2 Gene

Protein Domains for COPS2 Gene

UniProtKB/Swiss-Prot:

CSN2_HUMAN
Domain:
  • Contains 1 PCI domain.:
    • P61201
Family:
  • Belongs to the CSN2 family.:
    • P61201
genes like me logo Genes that share domains with COPS2: view

No data available for Gene Families for COPS2 Gene

Function for COPS2 Gene

Molecular function for COPS2 Gene

UniProtKB/Swiss-Prot Function: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.

Gene Ontology (GO) - Molecular Function for COPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity IEA --
GO:0004871 signal transducer activity NAS 9535219
GO:0005515 protein binding IPI 17438371
genes like me logo Genes that share ontologies with COPS2: view
genes like me logo Genes that share phenotypes with COPS2: view

miRNA for COPS2 Gene

miRTarBase miRNAs that target COPS2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for COPS2 Gene

Localization for COPS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COPS2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COPS2 Gene COMPARTMENTS Subcellular localization image for COPS2 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for COPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005737 cytoplasm IDA 9535219
GO:0008180 COP9 signalosome IDA 18850735
genes like me logo Genes that share ontologies with COPS2: view

Pathways for COPS2 Gene

genes like me logo Genes that share pathways with COPS2: view

Pathways by source for COPS2 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for COPS2 Gene
1 Qiagen pathway for COPS2 Gene
1 KEGG pathway for COPS2 Gene

Gene Ontology (GO) - Biological Process for COPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 7776974
GO:0007165 signal transduction NAS 9535219
GO:0008283 cell proliferation IEA --
GO:0010388 cullin deneddylation IDA 19141280
genes like me logo Genes that share ontologies with COPS2: view

Compounds for COPS2 Gene

(1) Novoseek inferred chemical compound relationships for COPS2 Gene

Compound -log(P) Hits PubMed IDs
retinoic acid 28.3 2
genes like me logo Genes that share compounds with COPS2: view

Transcripts for COPS2 Gene

Unigene Clusters for COPS2 Gene

COP9 signalosome subunit 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COPS2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - - -
SP2: - -
SP3:
SP4:

Relevant External Links for COPS2 Gene

GeneLoc Exon Structure for
COPS2
ECgene alternative splicing isoforms for
COPS2

Expression for COPS2 Gene

mRNA expression in normal human tissues for COPS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COPS2 Gene

SOURCE GeneReport for Unigene cluster for COPS2 Gene Hs.369614

genes like me logo Genes that share expressions with COPS2: view

Orthologs for COPS2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for COPS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COPS2 36
  • 99.93 (n)
  • 100 (a)
COPS2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia COPS2 37
  • 100 (a)
OneToOne
LOC613584 36
  • 97.63 (n)
  • 99.78 (a)
dog
(Canis familiaris)
Mammalia COPS2 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cops2 16
Cops2 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia COPS2 37
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COPS2 37
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves COPS2 37
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COPS2 37
  • 84 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4917 36
zebrafish
(Danio rerio)
Actinopterygii cops2 37
  • 99 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta alien 37
  • 83 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea csn-2 37
  • 56 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPN6 37
  • 19 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1993 36
soybean
(Glycine max)
eudicotyledons Gma.10229 36
barley
(Hordeum vulgare)
Liliopsida Hv.750 36
rice
(Oryza sativa)
Liliopsida Os.25964 36
wheat
(Triticum aestivum)
Liliopsida Ta.6931 36
bread mold
(Neurospora crassa)
Ascomycetes NCU00593 36
  • 55.45 (n)
  • 51.92 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes csn2 36
  • 58.01 (n)
  • 49.27 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4854 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 60 (a)
OneToMany
CSA.2309 37
  • 80 (a)
OneToMany
Species with no ortholog for COPS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for COPS2 Gene

ENSEMBL:
Gene Tree for COPS2 (if available)
TreeFam:
Gene Tree for COPS2 (if available)

Paralogs for COPS2 Gene

Paralogs for COPS2 Gene

Pseudogenes.org Pseudogenes for COPS2 Gene

genes like me logo Genes that share paralogs with COPS2: view

Variants for COPS2 Gene

Sequence variations from dbSNP and Humsavar for COPS2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs489813 -- 49,139,819(+) AATTA(C/T)CTTAA intron-variant
rs490621 -- 49,139,867(+) AGTTA(C/G)CTTAT intron-variant
rs491277 -- 49,133,137(+) GCGCC(C/T)GCCAC intron-variant
rs507054 -- 49,129,671(+) GGCAA(G/T)GATAT intron-variant
rs568994 -- 49,138,720(+) AATGA(C/T)ATCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COPS2 Gene

Variant ID Type Subtype PubMed ID
nsv827332 CNV Loss 20364138

Relevant External Links for COPS2 Gene

HapMap Linkage Disequilibrium report
COPS2
Human Gene Mutation Database (HGMD)
COPS2

Disorders for COPS2 Gene

(5) University of Copenhagen DISEASES for COPS2 Gene

genes like me logo Genes that share disorders with COPS2: view

No data available for UniProtKB/Swiss-Prot for COPS2 Gene

Publications for COPS2 Gene

  1. A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. (PMID: 9535219) Seeger M. … Dubiel W. (FASEB J. 1998) 2 3 4 23
  2. Interaction of the corepressor Alien with DAX-1 is abrogated by mutations of DAX-1 involved in adrenal hypoplasia congenita. (PMID: 10713076) Altincicek B. … Baniahmad A. (J. Biol. Chem. 2000) 3 4 23
  3. Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome. (PMID: 12628923) Uhle S. … Dubiel W. (EMBO J. 2003) 3 4 23
  4. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. (PMID: 7776974) Lee J.W. … Moore D.D. (Mol. Endocrinol. 1995) 2 3 4
  5. The nucleosome assembly activity of NAP1 is enhanced by Alien. (PMID: 17339334) Eckey M. … Baniahmad A. (Mol. Cell. Biol. 2007) 3 23

Products for COPS2 Gene

Sources for COPS2 Gene

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