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Aliases for COPS2 Gene

Aliases for COPS2 Gene

  • COP9 Signalosome Subunit 2 2 3 5
  • Thyroid Receptor-Interacting Protein 15 3 4
  • JAB1-Containing Signalosome Subunit 2 3 4
  • TR-Interacting Protein 15 3 4
  • Signalosome Subunit 2 3 4
  • Alien Homolog 3 4
  • TRIP-15 3 4
  • TRIP15 3 4
  • CSN2 3 4
  • SGN2 3 4
  • COP9 Constitutive Photomorphogenic Homolog Subunit 2 (Arabidopsis) 2
  • COP9 Constitutive Photomorphogenic Homolog Subunit 2 3
  • COP9 Signalosome Complex Subunit 2 3
  • ALIEN 3

External Ids for COPS2 Gene

Previous GeneCards Identifiers for COPS2 Gene

  • GC00U920616
  • GC15M047207
  • GC15M049417
  • GC15M026249

Summaries for COPS2 Gene

GeneCards Summary for COPS2 Gene

COPS2 (COP9 Signalosome Subunit 2) is a Protein Coding gene. Diseases associated with COPS2 include Persistent Hyperplastic Primary Vitreous. Among its related pathways are Vesicle-mediated transport and Transcription-Coupled Nucleotide Excision Repair (TC-NER). GO annotations related to this gene include signal transducer activity and transcription corepressor activity. An important paralog of this gene is PSMD11.

UniProtKB/Swiss-Prot for COPS2 Gene

  • Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.

Gene Wiki entry for COPS2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COPS2 Gene

Genomics for COPS2 Gene

Regulatory Elements for COPS2 Gene

Enhancers for COPS2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F049195 0.7 FANTOM5 12 -40.3 -40266 0.2 FEZF1 COPS2 GALK2 RN7SL307P GC15P049181
GH15F049154 0.5 ENCODE 0.8 0.0 -8 3.1 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 FGF7 DUT FBN1 ENSG00000259488 SECISBP2L FAM227B DTWD1 COPS2 NDUFAF4P1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around COPS2 on UCSC Golden Path with GeneCards custom track

Promoters for COPS2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000407666 -139 3601 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1

Genomic Location for COPS2 Gene

Chromosome:
15
Start:
49,106,068 bp from pter
End:
49,155,661 bp from pter
Size:
49,594 bases
Orientation:
Minus strand

Genomic View for COPS2 Gene

Genes around COPS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COPS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COPS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COPS2 Gene

Proteins for COPS2 Gene

  • Protein details for COPS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61201-CSN2_HUMAN
    Recommended name:
    COP9 signalosome complex subunit 2
    Protein Accession:
    P61201
    Secondary Accessions:
    • O88950
    • Q15647
    • Q6FGP4
    • Q9BY54
    • Q9R249
    • Q9UNI2
    • Q9UNQ5

    Protein attributes for COPS2 Gene

    Size:
    443 amino acids
    Molecular mass:
    51597 Da
    Quaternary structure:
    • Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 isoform 1 (PubMed:11337588, PubMed:18850735, PubMed:26456823). In the complex, it probably interacts directly with COPS1, COPS4, COPS5, COPS6 and COPS7 (COPS7A or COPS7B) (PubMed:11337588, PubMed:18850735). Specifically interacts with the ligand binding domain of the thyroid receptor (TR). Does not require the presence of thyroid hormone for its interaction (By similarity). Interacts with CUL1 and CUL2 (PubMed:11337588). Interacts with IRF8/ICSBP1 and with nuclear receptors NR2F1 and NR0B1 (PubMed:10207062, PubMed:10713076, PubMed:10991940). Interacts with NIF3L1 (By similarity).
    SequenceCaution:
    • Sequence=AAD30269.1; Type=Frameshift; Positions=304; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for COPS2 Gene

    Alternative splice isoforms for COPS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COPS2 Gene

Post-translational modifications for COPS2 Gene

  • Phosphorylated by CK2 and PKD kinases.
  • Ubiquitination at Lys 331, Lys 415, Lys 426, and Lys 441
  • Modification sites at PhosphoSitePlus

Other Protein References for COPS2 Gene

No data available for DME Specific Peptides for COPS2 Gene

Domains & Families for COPS2 Gene

Gene Families for COPS2 Gene

Protein Domains for COPS2 Gene

Suggested Antigen Peptide Sequences for COPS2 Gene

Graphical View of Domain Structure for InterPro Entry

P61201

UniProtKB/Swiss-Prot:

CSN2_HUMAN :
  • Contains 1 PCI domain.
  • Belongs to the CSN2 family.
Domain:
  • Contains 1 PCI domain.
Family:
  • Belongs to the CSN2 family.
genes like me logo Genes that share domains with COPS2: view

Function for COPS2 Gene

Molecular function for COPS2 Gene

UniProtKB/Swiss-Prot Function:
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.

Gene Ontology (GO) - Molecular Function for COPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity IEA,IBA --
GO:0004871 signal transducer activity NAS 9535219
GO:0005515 protein binding IPI 17438371
genes like me logo Genes that share ontologies with COPS2: view
genes like me logo Genes that share phenotypes with COPS2: view

Animal Model Products

miRNA for COPS2 Gene

miRTarBase miRNAs that target COPS2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COPS2 Gene

Localization for COPS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COPS2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COPS2 Gene COMPARTMENTS Subcellular localization image for COPS2 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for COPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,IDA 9535219
GO:0008180 COP9 signalosome IEA,IDA 9535219
genes like me logo Genes that share ontologies with COPS2: view

Pathways & Interactions for COPS2 Gene

genes like me logo Genes that share pathways with COPS2: view

Gene Ontology (GO) - Biological Process for COPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0000715 nucleotide-excision repair, DNA damage recognition TAS --
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0006366 transcription from RNA polymerase II promoter TAS 7776974
GO:0007165 signal transduction NAS 9535219
genes like me logo Genes that share ontologies with COPS2: view

No data available for SIGNOR curated interactions for COPS2 Gene

Drugs & Compounds for COPS2 Gene

(1) Additional Compounds for COPS2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with COPS2: view

Transcripts for COPS2 Gene

Unigene Clusters for COPS2 Gene

COP9 signalosome subunit 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COPS2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - - -
SP2: - -
SP3:
SP4:

Relevant External Links for COPS2 Gene

GeneLoc Exon Structure for
COPS2
ECgene alternative splicing isoforms for
COPS2

Expression for COPS2 Gene

mRNA expression in normal human tissues for COPS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for COPS2 Gene

This gene is overexpressed in Skin (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for COPS2 Gene



Protein tissue co-expression partners for COPS2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of COPS2 Gene:

COPS2

SOURCE GeneReport for Unigene cluster for COPS2 Gene:

Hs.369614
genes like me logo Genes that share expression patterns with COPS2: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for COPS2 Gene

Orthologs for COPS2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for COPS2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia COPS2 35
  • 100 (a)
OneToOne
LOC613584 34
  • 97.63 (n)
dog
(Canis familiaris)
Mammalia COPS2 35
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia COPS2 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cops2 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia COPS2 34 35
  • 99.93 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia COPS2 35
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves COPS2 35
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COPS2 35
  • 84 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cops2 35
  • 99 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4917 34
fruit fly
(Drosophila melanogaster)
Insecta alien 35
  • 83 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea csn-2 35
  • 56 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPN6 35
  • 19 (a)
OneToMany
soybean
(Glycine max)
eudicotyledons Gma.10229 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1993 34
barley
(Hordeum vulgare)
Liliopsida Hv.750 34
rice
(Oryza sativa)
Liliopsida Os.25964 34
wheat
(Triticum aestivum)
Liliopsida Ta.6931 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2309 35
  • 80 (a)
OneToMany
-- 35
  • 60 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes csn2 34
  • 58.01 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU00593 34
  • 55.45 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4854 34
Species where no ortholog for COPS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for COPS2 Gene

ENSEMBL:
Gene Tree for COPS2 (if available)
TreeFam:
Gene Tree for COPS2 (if available)

Paralogs for COPS2 Gene

Paralogs for COPS2 Gene

Pseudogenes.org Pseudogenes for COPS2 Gene

genes like me logo Genes that share paralogs with COPS2: view

Variants for COPS2 Gene

Sequence variations from dbSNP and Humsavar for COPS2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1048975 -- 49,125,349(-) ACTAC(A/C)AGAGC utr-variant-3-prime
rs10519211 -- 49,144,803(+) CATCA(C/G)GATAA intron-variant
rs111363659 -- 49,153,204(+) GATGA(C/T)TGGTT intron-variant
rs111598276 -- 49,151,857(+) CTTGG(A/G)CAGAA intron-variant
rs111747670 -- 49,141,230(+) GGCTT(C/G)GTGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COPS2 Gene

Variant ID Type Subtype PubMed ID
nsv827332 CNV loss 20364138

Variation tolerance for COPS2 Gene

Residual Variation Intolerance Score: 30.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 2.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COPS2 Gene

Human Gene Mutation Database (HGMD)
COPS2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
COPS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COPS2 Gene

Disorders for COPS2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for COPS2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
persistent hyperplastic primary vitreous
  • phpv
- elite association - COSMIC cancer census association via MalaCards
Search COPS2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for COPS2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COPS2
genes like me logo Genes that share disorders with COPS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for COPS2 Gene

Publications for COPS2 Gene

  1. A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. (PMID: 9535219) Seeger M. … Dubiel W. (FASEB J. 1998) 2 3 4 22 64
  2. Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome. (PMID: 12628923) Uhle S. … Dubiel W. (EMBO J. 2003) 3 4 22 64
  3. Interaction of the corepressor Alien with DAX-1 is abrogated by mutations of DAX-1 involved in adrenal hypoplasia congenita. (PMID: 10713076) Altincicek B. … Baniahmad A. (J. Biol. Chem. 2000) 3 4 22 64
  4. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. (PMID: 7776974) Lee J.W. … Moore D.D. (Mol. Endocrinol. 1995) 2 3 4 64
  5. CSNAP Is a Stoichiometric Subunit of the COP9 Signalosome. (PMID: 26456823) Rozen S. … Sharon M. (Cell Rep 2015) 3 4 64

Products for COPS2 Gene

Sources for COPS2 Gene

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