Aliases for COPRS Gene
External Ids for COPRS Gene
Previous Symbols for COPRS Gene
GeneCards Summary for COPRS Gene
COPRS (Coordinator Of PRMT5, Differentiation Stimulator) is a Protein Coding gene. GO annotations related to this gene include histone binding.
UniProtKB/Swiss-Prot for COPRS Gene
Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4 Arg-3 methylation mediated by PRMT5, but not histone H3 Arg-8 methylation, suggesting that it modulates the substrate specificity of PRMT5. Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5. Involved in CCNE1 promoter repression. Plays a role in muscle cell differentiation by modulating the recruitment of PRMT5 to the promoter of genes involved in the coordination between cell cycle exit and muscle differentiation (By similarity).