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Aliases for COPRS Gene

Aliases for COPRS Gene

  • Coordinator Of PRMT5 And Differentiation Stimulator 2 3
  • Coordinator Of PRMT5, Differentiation Stimulator 2 3 5
  • Cooperator Of PRMT5 2 3 4
  • C17orf79 3 4
  • COPR5 3 4
  • Chromosome 17 Open Reading Frame 79 2
  • Protein TTP1 4
  • HSA272196 3
  • TTP1 3

External Ids for COPRS Gene

Previous HGNC Symbols for COPRS Gene

  • C17orf79

Previous GeneCards Identifiers for COPRS Gene

  • GC17M030180

Summaries for COPRS Gene

GeneCards Summary for COPRS Gene

COPRS (Coordinator Of PRMT5 And Differentiation Stimulator) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Chromatin organization. GO annotations related to this gene include histone binding.

UniProtKB/Swiss-Prot for COPRS Gene

  • Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4 Arg-3 methylation mediated by PRMT5, but not histone H3 Arg-8 methylation, suggesting that it modulates the substrate specificity of PRMT5. Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5. Involved in CCNE1 promoter repression. Plays a role in muscle cell differentiation by modulating the recruitment of PRMT5 to the promoter of genes involved in the coordination between cell cycle exit and muscle differentiation (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COPRS Gene

Genomics for COPRS Gene

Regulatory Elements for COPRS Gene

Enhancers for COPRS Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around COPRS on UCSC Golden Path with GeneCards custom track

Promoters for COPRS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around COPRS on UCSC Golden Path with GeneCards custom track

Genomic Location for COPRS Gene

Chromosome:
17
Start:
31,851,864 bp from pter
End:
31,859,337 bp from pter
Size:
7,474 bases
Orientation:
Minus strand

Genomic View for COPRS Gene

Genes around COPRS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COPRS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COPRS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COPRS Gene

Proteins for COPRS Gene

  • Protein details for COPRS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQ92-COPRS_HUMAN
    Recommended name:
    Coordinator of PRMT5 and differentiation stimulator
    Protein Accession:
    Q9NQ92
    Secondary Accessions:
    • A6NP14
    • E1P656
    • Q96EF5
    • Q96P75

    Protein attributes for COPRS Gene

    Size:
    184 amino acids
    Molecular mass:
    20066 Da
    Quaternary structure:
    • Interacts with PRMT5. Interacts with histone H4; specifically interacts with the N-terminus of histone H4 but not with histone H3. Interacts with CBFB (By similarity). Found in a complex with PRMT5, RUNX1 and CBFB (By similarity).

neXtProt entry for COPRS Gene

Proteomics data for COPRS Gene at MOPED

Post-translational modifications for COPRS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for COPRS Gene

No data available for DME Specific Peptides for COPRS Gene

Domains & Families for COPRS Gene

Protein Domains for COPRS Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for COPRS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with COPRS: view

No data available for Gene Families and UniProtKB/Swiss-Prot for COPRS Gene

Function for COPRS Gene

Molecular function for COPRS Gene

UniProtKB/Swiss-Prot Function:
Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4 Arg-3 methylation mediated by PRMT5, but not histone H3 Arg-8 methylation, suggesting that it modulates the substrate specificity of PRMT5. Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5. Involved in CCNE1 promoter repression. Plays a role in muscle cell differentiation by modulating the recruitment of PRMT5 to the promoter of genes involved in the coordination between cell cycle exit and muscle differentiation (By similarity).
genes like me logo Genes that share phenotypes with COPRS: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COPRS Gene

Localization for COPRS Gene

Subcellular locations from UniProtKB/Swiss-Prot for COPRS Gene

Gene Ontology (GO) - Cellular Components for COPRS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with COPRS: view

No data available for Subcellular locations from COMPARTMENTS for COPRS Gene

Pathways & Interactions for COPRS Gene

genes like me logo Genes that share pathways with COPRS: view

Pathways by source for COPRS Gene

Gene Ontology (GO) - Biological Process for COPRS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0007517 muscle organ development IEA,ISS --
genes like me logo Genes that share ontologies with COPRS: view

No data available for SIGNOR curated interactions for COPRS Gene

Drugs & Compounds for COPRS Gene

No Compound Related Data Available

Transcripts for COPRS Gene

Unigene Clusters for COPRS Gene

Coordinator of PRMT5, differentiation stimulator:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COPRS Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: -
SP2:
SP3: - -

Relevant External Links for COPRS Gene

GeneLoc Exon Structure for
COPRS
ECgene alternative splicing isoforms for
COPRS

Expression for COPRS Gene

mRNA expression in normal human tissues for COPRS Gene

Protein differential expression in normal tissues from HIPED for COPRS Gene

This gene is overexpressed in Fetal ovary (64.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for COPRS Gene



SOURCE GeneReport for Unigene cluster for COPRS Gene Hs.462729

genes like me logo Genes that share expression patterns with COPRS: view

Protein tissue co-expression partners for COPRS Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for COPRS Gene

Orthologs for COPRS Gene

This gene was present in the common ancestor of mammals.

Orthologs for COPRS Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia COPRS 35
  • 85.33 (n)
  • 77.72 (a)
COPRS 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C9H17orf79 35
  • 82.83 (n)
  • 77.84 (a)
COPRS 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Coprs 35
  • 82.22 (n)
  • 78.18 (a)
Coprs 16
Coprs 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C17H17orf79 35
  • 97.46 (n)
  • 97.28 (a)
COPRS 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Coprs 35
  • 81.3 (n)
  • 76.22 (a)
oppossum
(Monodelphis domestica)
Mammalia COPRS 36
  • 43 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COPRS 36
  • 40 (a)
OneToOne
Species with no ortholog for COPRS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for COPRS Gene

ENSEMBL:
Gene Tree for COPRS (if available)
TreeFam:
Gene Tree for COPRS (if available)

Paralogs for COPRS Gene

Pseudogenes.org Pseudogenes for COPRS Gene

genes like me logo Genes that share paralogs with COPRS: view

No data available for Paralogs for COPRS Gene

Variants for COPRS Gene

Sequence variations from dbSNP and Humsavar for COPRS Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs8068049 - 31,856,838(+) CTGAC(C/T)GGAGT reference, missense
rs1044087 -- 31,852,029(-) CTAGT(C/T)TGGGG utr-variant-3-prime
rs2344310 -- 31,854,187(+) AATGT(C/T)GCAAA intron-variant
rs4795659 -- 31,860,120(+) TAGAA(C/G)GTTCT upstream-variant-2KB
rs8076057 -- 31,855,367(+) ccagg(C/T)gtggt intron-variant

Variation tolerance for COPRS Gene

Residual Variation Intolerance Score: 54.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 6.01% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for COPRS Gene

Disorders for COPRS Gene

Relevant External Links for COPRS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COPRS

No disorders were found for COPRS Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COPRS Gene

Publications for COPRS Gene

  1. The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5. (PMID: 18404153) Lacroix M. … Fabbrizio E. (EMBO Rep. 2008) 2 3 4 67
  2. A common set of at least 11 functional genes is lost in the majority of NF1 patients with gross deletions. (PMID: 10843809) Jenne D.E. … Thiel G. (Genomics 2000) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event. (PMID: 26527279) Campos E.I. … Reinberg D. (Mol. Cell 2015) 3

Products for COPRS Gene

Sources for COPRS Gene

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