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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

COPRS Gene

protein-coding   GIFtS: 37
GCID: GC17M030180

Coordinator Of PRMT5, Differentiation Stimulator

(Previous name: chromosome 17 open reading frame 79)
(Previous symbol: C17orf79)
  Search for COPRS
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Coordinator Of PRMT5, Differentiation Stimulator1 2     HSA2721962
C17orf791 2 3     TTP12
Cooperator Of PRMT51 2 3     Coordinator Of PRMT5 And Differentiation Stimulator2
COPR52 3     Protein TTP13
Chromosome 17 Open Reading Frame 791     

External Ids:    HGNC: 288481   Entrez Gene: 553522   Ensembl: ENSG000001723017   UniProtKB: Q9NQ923   

Export aliases for COPRS gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for COPRS Gene: 
COPRS (coordinator of PRMT5, differentiation stimulator) is a protein-coding gene. GO annotations related to this gene include protein binding and histone binding.

UniProtKB/Swiss-Prot: COPRS_HUMAN, Q9NQ92
Function: Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically
required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting
that it modulates the substrate specificity of PRMT5. Specifically interacts with the N-terminus of histone H4
but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5.
Involved in CCNE1 promoter repression. Plays a role in muscle cell differentiation by modulating the recruitment
of PRMT5 to the promoter of genes involved in the coordination between cell cycle exit and muscle differentiation
(By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010799.15  NC_018928.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for COPRS
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOPRS promoter sequence
   Search SABiosciences Chromatin IP Primers for COPRS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COPRS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11.2

COPRS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COPRS gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M030180:  view genomic region     (about GC identifiers)

Start:
30,178,883 bp from pter      End:
30,186,356 bp from pter
Size:
7,474 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: COPRS_HUMAN, Q9NQ92 (See protein sequence)
Recommended Name: Coordinator of PRMT5 and differentiation stimulator  
Size: 184 amino acids; 20066 Da
Subunit: Interacts with PRMT5. Interacts with histone H4; specifically interacts with the N-terminus of histone H4
but not with histone H3. Interacts with CBFB (By similarity). Found in a complex with PRMT5, RUNX1 and CBFB (By
similarity)
Subcellular location: Nucleus
Secondary accessions: A6NP14 E1P656 Q96EF5 Q96P75

Explore the universe of human proteins at neXtProt for COPRS: NX_Q9NQ92

Explore proteomics data for COPRS at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NQ92

  • COPRS Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    COPRS Protein Expression
    REFSEQ proteins: NP_060875.2  
    ENSEMBL proteins: 
     ENSP00000304327   ENSP00000367901   ENSP00000464423   ENSP00000464429   ENSP00000464425  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA18404153

    COPRS for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q9NQ92


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COPRS_HUMAN, Q9NQ92
    Function: Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically
    required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting
    that it modulates the substrate specificity of PRMT5. Specifically interacts with the N-terminus of histone H4
    but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5.
    Involved in CCNE1 promoter repression. Plays a role in muscle cell differentiation by modulating the recruitment
    of PRMT5 to the promoter of genes involved in the coordination between cell cycle exit and muscle differentiation
    (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18404153
    GO:0042393histone binding IDA18404153
         
    COPRS for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for COPRS:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for COPRS 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPRS


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for COPRS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/42 Interacting proteins for COPRS (Q9NQ922, 3 ENSP000003043274) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST4H4P628052, 3, ENSP000003507674MINT-6543302 MINT-6543349 MINT-6543323 I2D: score=2 STRING: ENSP00000350767
    HIST1H4AP628052, 3MINT-6543302 MINT-6543349 MINT-6543323 I2D: score=2 
    HIST1H4BP628052, 3MINT-6543302 MINT-6543349 MINT-6543323 I2D: score=2 
    HIST1H4CP628052, 3MINT-6543302 MINT-6543349 MINT-6543323 I2D: score=2 
    HIST1H4DP628052, 3MINT-6543302 MINT-6543349 MINT-6543323 I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0007517muscle organ development ISS--
    GO:0043985histone H4-R3 methylation IDA18404153

    COPRS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for COPRS

    Search CenterWatch for drugs/clinical trials and news about COPRS

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for COPRS gene: 
    NM_018405.3  

    Unigene Cluster for COPRS:

    Coordinator of PRMT5, differentiation stimulator
    Hs.462729  [show with all ESTs]
    Unigene Representative Sequence: BQ946887
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000302362(uc002hgp.3) ENST00000378634 ENST00000496655(uc010css.3)
    ENST00000579984 ENST00000579741
    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate COPRS
    SwitchGear 3'UTR luciferase reporter plasmidCOPRS 3' UTR sequence
    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of COPRS 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COPRS

    Additional mRNA sequence: 

    AF407672.1 AJ272196.2 AK024772.1 BC012386.1 BC035483.1 

    5 DOTS entries:

    DT.315408  DT.97845780  DT.40203840  DT.91886787  DT.92437580 

    24/272 AceView cDNA sequences (see all 272):

    AW593054 AA864256 AI471173 AF407672 AI950440 AI128220 AI913620 AI351671 
    BQ671832 AI245760 AW052150 CB070117 AI202802 BQ670405 BF002897 AI972290 
    CA307305 BU072069 AI870378 T32919 BM023523 T36063 AA394162 BF972948 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for COPRS    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c
    SP1:              -                                 
    SP2:                                                
    SP3:              -     -                           


    ECgene alternative splicing isoforms for COPRS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    COPRS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    COPRS Expression
    About this image


    See COPRS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for COPRS

    SOURCE GeneReport for Unigene cluster: Hs.462729
        SABiosciences Custom PCR Arrays for COPRS
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPRS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for COPRS gene from 1/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Coprs5
    2410022L05Rik1
    RIKEN cDNA 2410022L05 gene1, 5 81.26(n)1
    76.92(a)1
      8 (6.41 cM)5
    664231  NM_025556.31  NP_079832.11 
     138847885 


    ENSEMBL Gene Tree for COPRS (if available)
    TreeFam Gene Tree for COPRS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for COPRS gene

    COPRS for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for COPRS
    PGOHUM00000240365


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/182 SNPs in COPRS are shown (see all 182)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs799321231,2
    F--30178458(+) TGCTAG/CATCTA 1 -- int11Minor allele frequency- C:0.01NA 120
    rs1858216841,2
    --30178518(+) CCAAGC/TGTTTG 1 -- int10--------
    rs732780611,2
    C--30178519(+) CAAGCG/ATTTGA 1 -- int13Minor allele frequency- A:0.03WA NA 240
    rs1486695611,2
    --30178532(+) CTTTAA/CAATGT 1 -- int10--------
    rs1995132671,2
    --30178790(+) GTTCC-/AAACGA 1 -- int10--------
    rs80743831,2
    C,F,H--30178793(+) TCCAAT/CGAGCC 1 -- int119Minor allele frequency- C:0.08NS EA NA WA CSA 772
    rs1902976951,2
    --30179001(+) GACGGA/GGCCTT 1 -- ut310--------
    rs1413007651,2
    --30179033(+) ACACTC/GGTCTG 1 -- ut310--------
    rs1810698951,2
    C--30179137(+) CACCTA/GCAAGG 1 -- ut310--------
    rs2000904191,2
    --30179172(+) AGCATC/TGTCAA 2 N D mis10--------

    HapMap Linkage Disequilibrium report for COPRS (30178883 - 30186356 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for COPRS: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing COPRS
    DNA2.0 Custom Variant and Variant Library Synthesis for COPRS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for COPRS gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with COPRS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5. (PubMed id 18404153)1, 2, 3 Lacroix M....Fabbrizio E. (2008)
    2. A common set of at least 11 functional genes is lost in the majority of NF1 patients with gross deletions. (PubMed id 10843809)1, 2, 3 Jenne D.E.... Thiel G. (2000)
    3. Proteomic analysis of the NOS2 interactome in human ai rway epithelial cells. (PubMed id 23438482)1 Foster M.W....Marshall H.E. (2013)
    4. Deubiquitinase FAM/USP9X interacts with the E3 ubiquit in ligase SMURF1 protein and protects it from ligase activity-dependent self-deg radation. (PubMed id 23184937)1 Xie Y....Cong F. (2013)
    5. The histone- and PRMT5-associated protein COPR5 is req uired for myogenic differentiation. (PubMed id 22193545)1 Paul C....Fabbrizio E. (2012)
    6. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
    7. Functional specialization of beta-arrestin interactions revealed by proteomic analysis. (PubMed id 17620599)1 Xiao K....Lefkowitz R.J. (2007)
    8. Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth. (PubMed id 17632510)1 Douglas J.... Rahman N. (2007)
    9. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55352 HGNC: 28848 AceView: HSA272196 Ensembl:ENSG00000172301 euGenes: HUgn55352
    ECgene: COPRS H-InvDB: COPRS

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for COPRS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for COPRS gene:
    Search GeneIP for patents involving COPRS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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