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Aliases for COPRS Gene

Aliases for COPRS Gene

  • Coordinator Of PRMT5 And Differentiation Stimulator 2 3 5
  • Cooperator Of PRMT5 2 3 4
  • Coordinator Of PRMT5, Differentiation Stimulator 2 3
  • C17orf79 3 4
  • COPR5 3 4
  • Chromosome 17 Open Reading Frame 79 2
  • Protein TTP1 4
  • HSA272196 3
  • TTP1 3

External Ids for COPRS Gene

Previous HGNC Symbols for COPRS Gene

  • C17orf79

Previous GeneCards Identifiers for COPRS Gene

  • GC17M030180

Summaries for COPRS Gene

GeneCards Summary for COPRS Gene

COPRS (Coordinator Of PRMT5 And Differentiation Stimulator) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Chromatin organization. GO annotations related to this gene include histone binding.

UniProtKB/Swiss-Prot for COPRS Gene

  • Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4 Arg-3 methylation mediated by PRMT5, but not histone H3 Arg-8 methylation, suggesting that it modulates the substrate specificity of PRMT5. Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5. Involved in CCNE1 promoter repression. Plays a role in muscle cell differentiation by modulating the recruitment of PRMT5 to the promoter of genes involved in the coordination between cell cycle exit and muscle differentiation (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COPRS Gene

Genomics for COPRS Gene

Regulatory Elements for COPRS Gene

Enhancers for COPRS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F031923 0.5 Ensembl ENCODE 22.2 -64.5 -64523 1.5 BCOR LEF1 TAL1 NFRKB ZBTB40 GTF3C2 POLR2A NCOR1 ADNP NFE2 UTP6 COPRS SUZ12 DPRXP4 RNF135 ENSG00000264456
GH17F031858 0.2 ENCODE 20.8 +0.3 251 1.9 HDAC1 ARID4B SIN3A RAD21 ZNF366 EGR1 SCRT2 EGR2 USF2 TFDP1 COPRS PIR57755
GH17F031936 0.5 ENCODE 19.1 -78.1 -78078 2.5 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF263 UTP6 SUZ12 COPRS ENSG00000264456 LRRC37B RNF135 LOC105371722 RHOT1 RNA5SP437
GH17F031900 0.7 ENCODE 15.4 -42.2 -42191 1.7 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 PSMD11 COPRS UTP6 SUZ12 ENSG00000263990
GH17F031902 0.8 ENCODE 15.3 -43.5 -43520 0.2 IKZF1 ZNF512 JUNB COPRS UTP6 SUZ12
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around COPRS on UCSC Golden Path with GeneCards custom track

Promoters for COPRS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001344171 237 1401 HDAC1 ARID4B SIN3A RAD21 ZNF366 EGR1 EGR2 USF2 TFDP1 ZNF341

Genomic Location for COPRS Gene

Chromosome:
17
Start:
31,851,864 bp from pter
End:
31,859,337 bp from pter
Size:
7,474 bases
Orientation:
Minus strand

Genomic View for COPRS Gene

Genes around COPRS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COPRS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COPRS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COPRS Gene

Proteins for COPRS Gene

  • Protein details for COPRS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQ92-COPRS_HUMAN
    Recommended name:
    Coordinator of PRMT5 and differentiation stimulator
    Protein Accession:
    Q9NQ92
    Secondary Accessions:
    • A6NP14
    • E1P656
    • Q96EF5
    • Q96P75

    Protein attributes for COPRS Gene

    Size:
    184 amino acids
    Molecular mass:
    20066 Da
    Quaternary structure:
    • Interacts with PRMT5. Interacts with histone H4; specifically interacts with the N-terminus of histone H4 but not with histone H3. Interacts with CBFB (By similarity). Found in a complex with PRMT5, RUNX1 and CBFB (By similarity).

neXtProt entry for COPRS Gene

Post-translational modifications for COPRS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for COPRS Gene

No data available for DME Specific Peptides for COPRS Gene

Domains & Families for COPRS Gene

Protein Domains for COPRS Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for COPRS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with COPRS: view

No data available for Gene Families and UniProtKB/Swiss-Prot for COPRS Gene

Function for COPRS Gene

Molecular function for COPRS Gene

UniProtKB/Swiss-Prot Function:
Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4 Arg-3 methylation mediated by PRMT5, but not histone H3 Arg-8 methylation, suggesting that it modulates the substrate specificity of PRMT5. Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5. Involved in CCNE1 promoter repression. Plays a role in muscle cell differentiation by modulating the recruitment of PRMT5 to the promoter of genes involved in the coordination between cell cycle exit and muscle differentiation (By similarity).

Gene Ontology (GO) - Molecular Function for COPRS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18404153
GO:0042393 histone binding IEA,IDA 18404153
genes like me logo Genes that share ontologies with COPRS: view
genes like me logo Genes that share phenotypes with COPRS: view

Animal Models for COPRS Gene

MGI Knock Outs for COPRS:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for COPRS Gene

Localization for COPRS Gene

Subcellular locations from UniProtKB/Swiss-Prot for COPRS Gene

Gene Ontology (GO) - Cellular Components for COPRS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 18404153
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with COPRS: view

No data available for Subcellular locations from COMPARTMENTS for COPRS Gene

Pathways & Interactions for COPRS Gene

genes like me logo Genes that share pathways with COPRS: view

Pathways by source for COPRS Gene

Gene Ontology (GO) - Biological Process for COPRS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007517 muscle organ development ISS --
GO:0016569 covalent chromatin modification IEA --
GO:0043985 histone H4-R3 methylation IEA,IDA 18404153
genes like me logo Genes that share ontologies with COPRS: view

No data available for SIGNOR curated interactions for COPRS Gene

Transcripts for COPRS Gene

Unigene Clusters for COPRS Gene

Coordinator of PRMT5, differentiation stimulator:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COPRS Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: -
SP2:
SP3: - -

Relevant External Links for COPRS Gene

GeneLoc Exon Structure for
COPRS
ECgene alternative splicing isoforms for
COPRS

Expression for COPRS Gene

mRNA expression in normal human tissues for COPRS Gene

Protein differential expression in normal tissues from HIPED for COPRS Gene

This gene is overexpressed in Fetal ovary (64.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for COPRS Gene



Protein tissue co-expression partners for COPRS Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of COPRS Gene:

COPRS

SOURCE GeneReport for Unigene cluster for COPRS Gene:

Hs.462729
genes like me logo Genes that share expression patterns with COPRS: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for COPRS Gene

Orthologs for COPRS Gene

This gene was present in the common ancestor of mammals.

Orthologs for COPRS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C17H17orf79 34
  • 97.46 (n)
COPRS 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia COPRS 34 35
  • 85.33 (n)
dog
(Canis familiaris)
Mammalia COPRS 35
  • 84 (a)
OneToOne
C9H17orf79 34
  • 82.83 (n)
mouse
(Mus musculus)
Mammalia Coprs 34 16 35
  • 82.22 (n)
rat
(Rattus norvegicus)
Mammalia Coprs 34
  • 81.3 (n)
oppossum
(Monodelphis domestica)
Mammalia COPRS 35
  • 43 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COPRS 35
  • 40 (a)
OneToOne
Species where no ortholog for COPRS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for COPRS Gene

ENSEMBL:
Gene Tree for COPRS (if available)
TreeFam:
Gene Tree for COPRS (if available)

Paralogs for COPRS Gene

Pseudogenes.org Pseudogenes for COPRS Gene

genes like me logo Genes that share paralogs with COPRS: view

No data available for Paralogs for COPRS Gene

Variants for COPRS Gene

Sequence variations from dbSNP and Humsavar for COPRS Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1044087 -- 31,852,029(-) CTAGT(C/T)TGGGG utr-variant-3-prime
rs111905881 -- 31,852,274(+) TTAAG(C/T)TCTTG reference, synonymous-codon
rs112272042 -- 31,855,593(+) AGGCA(C/T)GAGAA intron-variant
rs113040110 -- 31,855,244(+) CAGTG(A/G)CTCAC intron-variant
rs113167166 -- 31,855,485(+) CAGAG(C/T)GAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COPRS Gene

Variant ID Type Subtype PubMed ID
nsv1062194 CNV gain 25217958
nsv1143851 CNV deletion 24896259

Variation tolerance for COPRS Gene

Residual Variation Intolerance Score: 54.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 6.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COPRS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
COPRS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COPRS Gene

Disorders for COPRS Gene

Relevant External Links for COPRS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COPRS

No disorders were found for COPRS Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COPRS Gene

Publications for COPRS Gene

  1. The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5. (PMID: 18404153) Lacroix M. … Fabbrizio E. (EMBO Rep. 2008) 2 3 4 64
  2. A common set of at least 11 functional genes is lost in the majority of NF1 patients with gross deletions. (PMID: 10843809) Jenne D.E. … Thiel G. (Genomics 2000) 2 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event. (PMID: 26527279) Campos E.I. … Reinberg D. (Mol. Cell 2015) 3 64

Products for COPRS Gene

Sources for COPRS Gene

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