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Aliases for COPG2 Gene

Aliases for COPG2 Gene

  • Coatomer Protein Complex, Subunit Gamma 2 2 3
  • Gamma-2-Coat Protein 3 4
  • Gamma-2-COP 3 4
  • Coat Protein, Nonclathrin, Gamma-2-Cop 3
  • Coat Protein 2
  • Nonclathrin 2
  • Gamma-2-Cop 2
  • 2-COP 3

External Ids for COPG2 Gene

Previous GeneCards Identifiers for COPG2 Gene

  • GC07M128622
  • GC07M129685
  • GC07M129700
  • GC07M129701
  • GC07M129741
  • GC07M129933
  • GC07M130146
  • GC07M124508

Summaries for COPG2 Gene

GeneCards Summary for COPG2 Gene

COPG2 (Coatomer Protein Complex, Subunit Gamma 2) is a Protein Coding gene. Diseases associated with COPG2 include silver-russell syndrome. Among its related pathways are G-protein signaling RAC1 in cellular process and wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF). GO annotations related to this gene include binding and structural molecule activity. An important paralog of this gene is COPG1.

UniProtKB/Swiss-Prot for COPG2 Gene

  • The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).

Gene Wiki entry for COPG2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COPG2 Gene

Genomics for COPG2 Gene

Regulatory Elements for COPG2 Gene

Genomic Location for COPG2 Gene

Chromosome:
7
Start:
130,506,238 bp from pter
End:
130,668,758 bp from pter
Size:
162,521 bases
Orientation:
Minus strand

Genomic View for COPG2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COPG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COPG2 Gene

Proteins for COPG2 Gene

  • Protein details for COPG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBF2-COPG2_HUMAN
    Recommended name:
    Coatomer subunit gamma-2
    Protein Accession:
    Q9UBF2
    Secondary Accessions:
    • A6NH74
    • Q2NLA0
    • Q54AC3
    • Q8WVW8

    Protein attributes for COPG2 Gene

    Size:
    871 amino acids
    Molecular mass:
    97622 Da
    Quaternary structure:
    • Oligomeric complex. Binds to CDC42. Interacts with JAGN1.

    Alternative splice isoforms for COPG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COPG2 Gene

Proteomics data for COPG2 Gene at MOPED

Post-translational modifications for COPG2 Gene

  • Ubiquitination at Lys 461 and Lys 572
  • Modification sites at PhosphoSitePlus

Other Protein References for COPG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for COPG2 Gene

Domains & Families for COPG2 Gene

Suggested Antigen Peptide Sequences for COPG2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UBF2

UniProtKB/Swiss-Prot:

COPG2_HUMAN :
  • Belongs to the COPG family.
  • Contains 6 HEAT repeats.
Family:
  • Belongs to the COPG family.
Similarity:
  • Contains 6 HEAT repeats.
genes like me logo Genes that share domains with COPG2: view

No data available for Gene Families for COPG2 Gene

Function for COPG2 Gene

Molecular function for COPG2 Gene

GENATLAS Biochemistry:
Golgi coatomer complex,gamma 2 subunit,component of the coat of non clathrin-coated vesicles,ubiquitously expressed from the paternal allele in most fetal tissues (maternally imprinted),expressed from both alleles in fetal brain,liver and adult peripheral blood,not likely to be involved in Silver-Russell syndrome
UniProtKB/Swiss-Prot Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).

Gene Ontology (GO) - Molecular Function for COPG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005488 binding --
genes like me logo Genes that share ontologies with COPG2: view
genes like me logo Genes that share phenotypes with COPG2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COPG2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for COPG2 Gene

Localization for COPG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COPG2 Gene

Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Tends to be more abundant in the trans-Golgi network compared to the cis-Golgi. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COPG2 Gene COMPARTMENTS Subcellular localization image for COPG2 gene
Compartment Confidence
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for COPG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
GO:0030117 membrane coat --
GO:0030126 COPI vesicle coat IDA 1472999
genes like me logo Genes that share ontologies with COPG2: view

Pathways & Interactions for COPG2 Gene

genes like me logo Genes that share pathways with COPG2: view

Gene Ontology (GO) - Biological Process for COPG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS 11030615
GO:0006891 intra-Golgi vesicle-mediated transport IDA 11056392
GO:0016192 vesicle-mediated transport --
genes like me logo Genes that share ontologies with COPG2: view

No data available for SIGNOR curated interactions for COPG2 Gene

Drugs & Compounds for COPG2 Gene

(1) Drugs for COPG2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with COPG2: view

Transcripts for COPG2 Gene

mRNA/cDNA for COPG2 Gene

Unigene Clusters for COPG2 Gene

Coatomer protein complex, subunit gamma 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COPG2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COPG2 Gene

No ASD Table

Relevant External Links for COPG2 Gene

GeneLoc Exon Structure for
COPG2
ECgene alternative splicing isoforms for
COPG2

Expression for COPG2 Gene

mRNA expression in normal human tissues for COPG2 Gene

Protein differential expression in normal tissues from HIPED for COPG2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for COPG2 Gene



SOURCE GeneReport for Unigene cluster for COPG2 Gene Hs.6421

genes like me logo Genes that share expression patterns with COPG2: view

Protein tissue co-expression partners for COPG2 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for COPG2 Gene

Orthologs for COPG2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for COPG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COPG2 36
  • 100 (a)
OneToOne
COPG2 35
  • 99.89 (n)
  • 100 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia COPG2 36
  • 28 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Copg2 36
  • 28 (a)
OneToOne
Copg2 16
Copg2 35
  • 91.01 (n)
  • 97.59 (a)
oppossum
(Monodelphis domestica)
Mammalia COPG2 36
  • 28 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COPG2 36
  • 23 (a)
OneToOne
COPG2 35
  • 93.03 (n)
  • 96.65 (a)
cow
(Bos Taurus)
Mammalia COPG2 36
  • 28 (a)
OneToOne
COPG2 35
  • 93.03 (n)
  • 96.33 (a)
rat
(Rattus norvegicus)
Mammalia Copg2 35
  • 91.35 (n)
  • 97.47 (a)
chicken
(Gallus gallus)
Aves COPG2 36
  • 27 (a)
OneToOne
COPG2 35
  • 81.52 (n)
  • 93.8 (a)
lizard
(Anolis carolinensis)
Reptilia COPG2 36
  • 27 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia copg2 35
  • 78.15 (n)
  • 90.01 (a)
zebrafish
(Danio rerio)
Actinopterygii copg2 36
  • 26 (a)
OneToOne
copg2 35
  • 76.5 (n)
  • 88.63 (a)
fruit fly
(Drosophila melanogaster)
Insecta gammaCop 36
  • 18 (a)
OneToMany
gammaCop 35
  • 57.74 (n)
  • 60.25 (a)
gammaCop 37
  • 59 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009291 35
  • 57.72 (n)
  • 61.11 (a)
worm
(Caenorhabditis elegans)
Secernentea T14G10.5 36
  • 17 (a)
OneToMany
T14G10.5 35
  • 57.22 (n)
  • 56.45 (a)
T14G10.5 37
  • 55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC21 36
  • 9 (a)
OneToMany
SEC21 35
  • 47.96 (n)
  • 39.31 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E13289g 35
  • 47.74 (n)
  • 37.43 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL193W 35
  • 46.9 (n)
  • 39.98 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G34450 35
  • 57.67 (n)
  • 54.09 (a)
rice
(Oryza sativa)
Liliopsida Os03g0227000 35
  • 55.95 (n)
  • 53.74 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.452 36
  • 57 (a)
ManyToMany
-- 36
  • 9 (a)
ManyToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sec21 35
  • 50.78 (n)
  • 41.49 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01992 35
  • 52.71 (n)
  • 48.02 (a)
Species with no ortholog for COPG2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for COPG2 Gene

ENSEMBL:
Gene Tree for COPG2 (if available)
TreeFam:
Gene Tree for COPG2 (if available)

Paralogs for COPG2 Gene

Paralogs for COPG2 Gene

(3) SIMAP similar genes for COPG2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with COPG2: view

Variants for COPG2 Gene

Sequence variations from dbSNP and Humsavar for COPG2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1814 -- 130,645,623(+) AACAT(A/G)GGTGC intron-variant
rs10128 - 130,511,853(+) AAAGC(G/T)TTTGA intron-variant
rs158682 -- 130,641,097(+) CACTT(G/T)GGGAG intron-variant
rs565579 -- 130,646,931(-) atata(C/T)aCACA intron-variant
rs933752 -- 130,641,968(+) AAACC(A/G)GGACG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COPG2 Gene

Variant ID Type Subtype PubMed ID
nsv831130 CNV Loss 17160897
nsv831131 CNV Loss 17160897
nsv831132 CNV Gain+Loss 17160897

Variation tolerance for COPG2 Gene

Gene Damage Index Score: 0.88; 18.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COPG2 Gene

HapMap Linkage Disequilibrium report
COPG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COPG2 Gene

Disorders for COPG2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for COPG2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
silver-russell syndrome
  • silver russell dwarfism
- elite association
Search COPG2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for COPG2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COPG2
genes like me logo Genes that share disorders with COPG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for COPG2 Gene

Publications for COPG2 Gene

  1. The novel gene, gamma2-COP (COPG2), in the 7q32 imprinted domain escapes genomic imprinting. (PMID: 10995575) Yamasaki K. … Kishino T. (Genomics 2000) 2 23 67
  2. Identification of two new polymorphisms (c2447-125A>G; c2532G>A) in the gamma 2-COP (COPG2) gene by screening of Silver-Russell syndrome patients. (PMID: 10874328) Mergenthaler S. … Eggermann T. (Hum. Mutat. 2000) 23 67
  3. Molecular cloning and characterization of the Fugu rubripes MEST/COPG2 imprinting cluster and chromosomal localization in Fugu and Tetraodon nigroviridis. (PMID: 11032317) Brunner B. … Kalscheuer V.M. (Chromosome Res. 2000) 23 67
  4. Gamma2-COP, a novel imprinted gene on chromosome 7q32, defines a new imprinting cluster in the human genome. (PMID: 10556286) Blagitko N. … Kalscheuer V.M. (Hum. Mol. Genet. 1999) 2 67
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67

Products for COPG2 Gene

Sources for COPG2 Gene

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