Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

COPG2 Gene

protein-coding   GIFtS: 55
GCID: GC07M130146

Coatomer Protein Complex, Subunit Gamma 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Coatomer Protein Complex, Subunit Gamma 21 2     2-COP2
Gamma-2-Coat Protein2 3     Coat Protein, Nonclathrin, Gamma-2-Cop2
Coat Protein1     Coatomer Subunit Gamma-22
gamma-2-cop1     gamma-2-COP2
nonclathrin1     Gamma-2-COP3

External Ids:    HGNC: 22371   Entrez Gene: 269582   Ensembl: ENSG000001586237   OMIM: 6043555   UniProtKB: Q9UBF23   

Export aliases for COPG2 gene to outside databases

Previous GC identifers: GC07M128622 GC07M129685 GC07M129700 GC07M129701 GC07M129741 GC07M129933 GC07M124508


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for COPG2 Gene: 
COPG2 (coatomer protein complex, subunit gamma 2) is a protein-coding gene. Diseases associated with COPG2 include silver-russell syndrome, and splenic marginal zone lymphoma, and among its related super-pathways are Clathrin-dependent protein traffic and COPII (Coat Protein 2) Mediated Vesicle Transport. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is COPG1.

UniProtKB/Swiss-Prot: COPG2_HUMAN, Q9UBF2
Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with
Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the
Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is
essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only
be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins;
the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic
recycling of LDL receptors (By similarity)

Gene Wiki entry for COPG2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007933.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the COPG2 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-2   MZF-1   E2F-1   E2F   POU2F1   POU2F1a   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOPG2 promoter sequence
   Search SABiosciences Chromatin IP Primers for COPG2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COPG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q32   Ensembl cytogenetic band:  7q32.2   HGNC cytogenetic band: 7q32

COPG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COPG2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M130146:  view genomic region     (about GC identifiers)

Start:
130,146,079 bp from pter      End:
130,353,598 bp from pter
Size:
207,520 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 129,531,485-129,690,100     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: COPG2_HUMAN, Q9UBF2 (See protein sequence)
Recommended Name: Coatomer subunit gamma-2  
Size: 871 amino acids; 97622 Da
Subunit: Oligomeric complex. Binds to CDC42
Subcellular location: Cytoplasm (By similarity). Golgi apparatus membrane; Peripheral membrane protein;
Cytoplasmic side (By similarity). Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein;
Cytoplasmic side (By similarity). Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the
Golgi, as well as on the vesicles/buds originating from it (By similarity)
Secondary accessions: A6NH74 Q54AC3 Q8WVW8

Explore the universe of human proteins at neXtProt for COPG2: NX_Q9UBF2

Explore proteomics data for COPG2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UBF2

  • COPG2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    COPG2 Protein Expression
    REFSEQ proteins: NP_036265.3  
    ENSEMBL proteins: 
     ENSP00000402346   ENSP00000331218   ENSP00000393912  

    Human Recombinant Protein Products for COPG2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for COPG2
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for COPG2
    GenScript Custom Purified and Recombinant Proteins Services for COPG2
    Novus Biologicals COPG2 Proteins
    Novus Biologicals COPG2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030117membrane coat ----
    GO:0030126COPI vesicle coat IDA11056392

    COPG2 for ontologies           About GeneDecksing



    COPG2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for COPG2
    GenScript Custom Superior Antibodies Services for COPG2
    Novus Biologicals COPG2 Antibodies
    Abcam antibodies for COPG2
    Browse Antibodies at Cloud-Clone Corp. 
    Search ThermoFisher Antibodies for COPG2
    LSBio Antibodies in human, mouse, rat for COPG2 

    Assay Products for COPG2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for COPG2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for COPG2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/9 InterPro protein domains (see all 9):
     IPR011989 ARM-like
     IPR002553 Clathrin/coatomer_adapt-like_N
     IPR017106 Coatomer_gsu
     IPR013041 Coatomer/clathrin_app_Ig-like
     IPR013040 Coatomer_gsu_app_Ig-like-sub

    Graphical View of Domain Structure for InterPro Entry Q9UBF2

    ProtoNet protein and cluster: Q9UBF2

    1 Blocks protein domain: IPB002553 Adaptin

    UniProtKB/Swiss-Prot: COPG2_HUMAN, Q9UBF2
    Similarity: Belongs to the COPG family
    Similarity: Contains 6 HEAT repeats


    COPG2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COPG2_HUMAN, Q9UBF2
    Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with
    Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the
    Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is
    essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only
    be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins;
    the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic
    recycling of LDL receptors (By similarity)

         Genatlas biochemistry entry for COPG2:
    Golgi coatomer complex,gamma 2 subunit,component of the coat of non clathrin-coated vesicles,ubiquitously
    expressed from the paternal allele in most fetal tissues (maternally imprinted),expressed from both alleles in
    fetal brain,liver and adult peripheral blood,not likely to be involved in Silver-Russell syndrome

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0005488binding ----
         
    COPG2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for COPG2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for COPG2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for COPG2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for COPG2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COPG2
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate COPG2:
    hsa-miR-4314 hsa-miR-548t hsa-miR-3662 hsa-miR-548c-3p hsa-miR-646
    SwitchGear 3'UTR luciferase reporter plasmidCOPG2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for COPG2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COPG2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for COPG2
    Sirion Biotech Customized adenovirus for overexpression of COPG2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for COPG2 (see all 7)
    OriGene ORF clones in mouse, rat for COPG2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: COPG2 (NM_012133)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COPG2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COPG2
    Sirion Biotech Customized lentivirus for stable overexpression of COPG2 
                         Customized lentivirus expression plasmids for stable overexpression of COPG2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for COPG2
    Search LifeMap BioReagents cell lines for COPG2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPG2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for COPG2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Clathrin-dependent protein traffic
    Clathrin-dependent protein traffic0.66
    wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)0.37
    Transport Clathrin-coated vesicle cycle0.66
    2COPII (Coat Protein 2) Mediated Vesicle Transport
    Delta508-CFTR traffic / ER-to-Golgi in CF0.36
    Normal wtCFTR traffic / ER-to-Golgi 0.36
    3Cytoskeleton remodeling CDC42 in cellular processes
    Cytoskeleton remodeling CDC42 in cellular processes0.37
    4Golgi to ER Retrograde Transport
    Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF)0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for COPG2
        Clathrin-dependent protein traffic
    Cytoskeleton remodeling CDC42 in cellular processes


    5/6 GeneGo (Thomson Reuters) Pathways for COPG2 (see all 6)
        wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
    Delta508-CFTR traffic / ER-to-Golgi in CF
    Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF)
    Normal wtCFTR traffic / ER-to-Golgi
    Cytoskeleton remodeling CDC42 in cellular processes



    COPG2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for COPG2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/893 Interacting proteins for COPG2 (Q9UBF22, 3 ENSP000003939124) via UniProtKB, MINT, STRING, and/or I2D (see all 893)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COPB1P536182, 3, ENSP000002499234MINT-7945693 MINT-7947479 I2D: score=7 STRING: ENSP00000249923
    ARCN1P484442, 3, ENSP000002640284MINT-7945693 MINT-7947479 I2D: score=6 STRING: ENSP00000264028
    COPAP536212, 3, ENSP000003570484MINT-7945693 MINT-7947479 I2D: score=5 STRING: ENSP00000357048
    COPG1Q9Y6782, 3, ENSP000003250024MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000325002
    EIF3IQ133472, 3MINT-7945693 MINT-7947479 I2D: score=4 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0006890retrograde vesicle-mediated transport, Golgi to ER TAS11030615
    GO:0006891intra-Golgi vesicle-mediated transport IDA11056392
    GO:0016192vesicle-mediated transport ----

    COPG2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for COPG2

    1 HMDB Compound for COPG2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about COPG2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for COPG2 gene: 
    NM_012133.4  

    Unigene Cluster for COPG2:

    Coatomer protein complex, subunit gamma 2
    Hs.6421  [show with all ESTs]
    Unigene Representative Sequence: NM_012133
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000425248(uc003vqh.1) ENST00000490070 ENST00000330992 ENST00000445977

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COPG2
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate COPG2:
    hsa-miR-4314 hsa-miR-548t hsa-miR-3662 hsa-miR-548c-3p hsa-miR-646
    SwitchGear 3'UTR luciferase reporter plasmidCOPG2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for COPG2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COPG2
    Clone
    Products:
         
    OriGene clones in human, mouse for COPG2 (see all 7)
    OriGene ORF clones in mouse, rat for COPG2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: COPG2 (NM_012133)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COPG2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COPG2
    Sirion Biotech Customized lentivirus for stable overexpression of COPG2 
                         Customized lentivirus expression plasmids for stable overexpression of COPG2 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for COPG2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat COPG2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COPG2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COPG2

    Additional mRNA sequence: 

    AB047847.1 AF157833.1 AF207598.1 AF308295.1 AK002086.1 AK022934.1 AK024414.1 AK291409.1 
    AL162012.1 BC017443.1 BC110796.1 

    9 DOTS entries:

    DT.95328531  DT.95094686  DT.114640  DT.100764935  DT.409575  DT.92425799  DT.100044641  DT.95271164 
    DT.121100561 

    24/91 AceView cDNA sequences (see all 91):

    BU952531 AW779612 BI826509 AF294347 BQ269562 BU621332 BE255440 BU501717 
    AF431815 BQ949550 BQ049150 BI222381 CR593178 BU689642 BQ286198 AA774034 
    AI198538 BC038415 BX375975 AI190158 BM563469 BG718201 NM_052933 AX748057 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    COPG2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    COPG2 Expression
    About this image


    See COPG2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for COPG2

    SOURCE GeneReport for Unigene cluster: Hs.6421
        SABiosciences Custom PCR Arrays for COPG2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for COPG2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat COPG2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COPG2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COPG2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPG2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for COPG2 gene from 9/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Copg21 , 5 coatomer protein complex, subunit gamma 21, 5 91.01(n)1
    97.59(a)1
      6 (12.54 cM)5
    541601  NM_017478.21  NP_059506.11 
     308584275 
    chicken
    (Gallus gallus)
    Aves COPG21 coatomer protein complex, subunit gamma 2 81.52(n)
    93.8(a)
      416685  XM_414981.3  XP_414981.2 
    lizard
    (Anolis carolinensis)
    Reptilia COPG26
    Coatomer subunit gamma
    27(a)
    1 ↔ 1
    GL343728.1(240642-275884)
    zebrafish
    (Danio rerio)
    Actinopterygii copg21 coatomer protein complex, subunit gamma 2 76.5(n)
    88.63(a)
      30187  NM_130994.1  NP_571069.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta &ggr;Cop3
    gammaCop1
    retrograde (Golgi to ER) transport3
    gamma-coatomer protein1
    59(a)3
    57.74(n)1
    60.25(a)1
      100C63
    437171  NM_079869.31  NP_524608.11 
    worm
    (Caenorhabditis elegans)
    Secernentea T14G10.51 , 3 protein transport protein3
    Protein T14G10.51
    55(a)3
    57.15(n)1
    56.26(a)1
      IV(10152526-10155606)3
    1778911  NM_001047524.21  NP_001040989.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SEC211 Sec21p 47.6(n)
    38.25(a)
      855429   NP_014112.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G344501 coatomer subunit gamma 57.75(n)
    54.21(a)
      829596  NM_119610.3  NP_195171.2 
    rice
    (Oryza sativa)
    Liliopsida Os07g02011001 hypothetical protein 56.81(n)
    53.64(a)
      4342665  NM_001065666.1  NP_001059131.1 


    ENSEMBL Gene Tree for COPG2 (if available)
    TreeFam Gene Tree for COPG2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for COPG2 gene
    COPG12  
    3 SIMAP similar genes for COPG2 using alignment to 5 protein entries:     COPG2_HUMAN (see all proteins):
    DKFZp761N09121    COPG1    COPG

    COPG2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2016 SNPs in COPG2 are shown (see all 2016)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1455366301,2
    --124579383(+) TCAGGA/GGCCAA 1 -- int10--------
    rs3714452681,2
    C--124582390(+) GCCAAA/GCATGA 1 -- int10--------
    rs1807149951,2
    C--124582666(+) CTACTA/TTAAAG 1 -- int10--------
    rs1511001291,2
    C--124584460(+) GAGCGA/GGACTC 1 -- int10--------
    rs1870791491,2
    C--124592296(+) CTCTGC/TCCGGC 1 -- int10--------
    rs755016351,2
    F--129532068(+) AAAGTA/GAGGAA 1 -- int10--------
    rs132345671,2
    H--129532075(+) GGAAAA/CCCATA 1 -- int14Minor allele frequency- C:0.00NS EA 416
    rs1416760331,2
    C,F--129532085(+) ATTAAG/CAACCC 1 -- int11Minor allele frequency- C:0.00EU 591
    rs23028251,2
    C,F,H--129532424(+) AATGGG/CATGAT 1 -- int16Minor allele frequency- C:0.06EA NS 2034
    rs18051661,2
    C--129532533(-) CATTCG/ACTCTA 2 /S syn11Minor allele frequency- A:0.00EU 569

    HapMap Linkage Disequilibrium report for COPG2 (130146079 - 130353598 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for COPG2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831131CNV Loss17160897
    nsv831130CNV Loss17160897
    nsv831132CNV Gain+Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing COPG2
    DNA2.0 Custom Variant and Variant Library Synthesis for COPG2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604355    OMIM disorders: --

    4 diseases for COPG2:    About MalaCards
    silver-russell syndrome    splenic marginal zone lymphoma    gout    breast cancer

    2 diseases from the University of Copenhagen DISEASES database for COPG2:
    Silver-Russell syndrome     Splenic marginal zone lymphoma

    COPG2 for disorders           About GeneDecksing


    Export disorders for COPG2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for COPG2 gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with COPG2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Gamma2-COP, a novel imprinted gene on chromosome 7q32, defines a new imprinting cluster in the human genome. (PubMed id 10556286)1, 2, 3 Blagitko N.... Kalscheuer V.M. (1999)
    2. The novel gene, gamma2-COP (COPG2), in the 7q32 imprinted domain escapes genomic imprinting. (PubMed id 10995575)1, 3, 9 Yamasaki K....Kishino T. (2000)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    5. Identification and characterization of novel isoforms of COP I subunits. (PubMed id 11056392)1, 2 Futatsumori M.... Nakayama K. (2000)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    8. Methylation and expression analyses of the 7q autism s usceptibility locus genes MEST , COPG2, and TSGA14 in human and anthropoid prima te cortices. (PubMed id 22456293)1 Schneider E....Haaf T. (2012)
    9. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26958 HGNC: 2237 AceView: COPG2 Ensembl:ENSG00000158623 euGenes: HUgn26958
    ECgene: COPG2 H-InvDB: COPG2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for COPG2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for COPG2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for COPG2 gene:
    Search GeneIP for patents involving COPG2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for COPG2  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for COPG2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for COPG2  
     OriGene qSTAR qPCR primer pairs in human, mouse for COPG2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for COPG2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for COPG2   OriGene Custom Protein Services for COPG2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat COPG2
     QIAGEN SeqTarget long-range PCR primers for resequencing COPG2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COPG2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COPG2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COPG2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COPG2
     GenScript Custom Purified and Recombinant Proteins Services for COPG2 GenScript cDNA clones with any tag delivered in your preferred vector for COPG2
     GenScript Custom Assay Services for COPG2 GenScript Custom Superior Antibodies Services for COPG2
     GenScript Custom overexpressing Cell Line Services for COPG2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in COPG2 promoter
     Search Chromatin IP Primers for COPG2
     RT2 qPCR Primer Assay in human, mouse, rat COPG2
     Search GNC Networks for COPG2
     SABiosciences Custom PCR Arrays for COPG2
     Search Tocris compounds for COPG2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     COPG2 antibodies
     COPG2 proteins
     COPG2 lysates
     Antibodies for COPG2
     See all of Abcam's Antibodies, Kits and Proteins for COPG2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for COPG2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPG2
     SwitchGear 3'UTR luciferase reporter plasmids for COPG2
     SwitchGear Promoter luciferase reporter plasmids for COPG2
     Search ThermoFisher Antibodies for COPG2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COPG2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for COPG2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for COPG2
    Customized:
     lentivirus for stable overexpression of COPG2
     lentivirus expression plasmids for stable overexpression of COPG2
     adenovirus for overexpression of COPG2
     LSBio Antibodies in human, mouse, rat for COPG2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      COPG2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4