Aliases for COPG2 Gene
External Ids for COPG2 Gene
Previous GeneCards Identifiers for COPG2 Gene
GeneCards Summary for COPG2 Gene
COPG2 (Coatomer Protein Complex Subunit Gamma 2) is a Protein Coding gene. Diseases associated with COPG2 include Silver-Russell Syndrome. Among its related pathways are Golgi-to-ER retrograde transport and Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF). GO annotations related to this gene include binding and structural molecule activity. An important paralog of this gene is COPG1.
UniProtKB/Swiss-Prot for COPG2 Gene
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).