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COPG2 Gene

protein-coding   GIFtS: 55
GCID: GC07M130146

Coatomer Protein Complex, Subunit Gamma 2

  Search for COPG2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Coatomer Protein Complex, Subunit Gamma 21 2     2-COP2
Gamma-2-Coat Protein2 3     Coat Protein, Nonclathrin, Gamma-2-Cop2
Coat Protein1     Coatomer Subunit Gamma-22
gamma-2-cop1     gamma-2-COP2
nonclathrin1     Gamma-2-COP3

External Ids:    HGNC: 22371   Entrez Gene: 269582   Ensembl: ENSG000001586237   OMIM: 6043555   UniProtKB: Q9UBF23   

Export aliases for COPG2 gene to outside databases

Previous GC identifers: GC07M128622 GC07M129685 GC07M129700 GC07M129701 GC07M129741 GC07M129933 GC07M124508


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for COPG2 Gene:
COPG2 (coatomer protein complex, subunit gamma 2) is a protein-coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is COPG1.

UniProtKB/Swiss-Prot: COPG2_HUMAN, Q9UBF2
Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with
Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the
Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is
essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only
be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins;
the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic
recycling of LDL receptors (By similarity)

Gene Wiki entry for COPG2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the COPG2 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-2   MZF-1   E2F-1   E2F   POU2F1   POU2F1a   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOPG2 promoter sequence
   Search Chromatin IP Primers for COPG2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COPG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q32   Ensembl cytogenetic band:  7q32.2   HGNC cytogenetic band: 7q32

COPG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COPG2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M130146:  view genomic region     (about GC identifiers)

Start:
130,146,079 bp from pter      End:
130,353,598 bp from pter
Size:
207,520 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 129,531,485-129,690,100     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: COPG2_HUMAN, Q9UBF2 (See protein sequence)
Recommended Name: Coatomer subunit gamma-2  
Size: 871 amino acids; 97622 Da
Subunit: Oligomeric complex. Binds to CDC42
Secondary accessions: A6NH74 Q54AC3 Q8WVW8

Explore the universe of human proteins at neXtProt for COPG2: NX_Q9UBF2

Explore proteomics data for COPG2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys461, Lys572
  • Modification sites at PhosphoSitePlus

  • See COPG2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001276962.1  NP_036265.3  

    ENSEMBL proteins: 
     ENSP00000402346   ENSP00000331218   ENSP00000393912  

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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for COPG2 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 8):
     IPR011989 ARM-like
     IPR002553 Clathrin/coatomer_adapt-like_N
     IPR017106 Coatomer_gsu
     IPR013041 Coatomer/clathrin_app_Ig-like
     IPR013040 Coatomer_gsu_app_Ig-like-sub

    Graphical View of Domain Structure for InterPro Entry Q9UBF2

    ProtoNet protein and cluster: Q9UBF2

    1 Blocks protein domain: IPB002553 Adaptin

    UniProtKB/Swiss-Prot: COPG2_HUMAN, Q9UBF2
    Similarity: Belongs to the COPG family
    Similarity: Contains 6 HEAT repeats


    Find genes that share domains with COPG2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COPG2_HUMAN, Q9UBF2
    Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with
    Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the
    Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is
    essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only
    be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins;
    the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic
    recycling of LDL receptors (By similarity)

         Genatlas biochemistry entry for COPG2:
    Golgi coatomer complex,gamma 2 subunit,component of the coat of non clathrin-coated vesicles,ubiquitously
    expressed from the paternal allele in most fetal tissues (maternally imprinted),expressed from both alleles in
    fetal brain,liver and adult peripheral blood,not likely to be involved in Silver-Russell syndrome

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0005488binding ----
         
    Find genes that share ontologies with COPG2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for COPG2
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    SwitchGear 3'UTR luciferase reporter plasmidCOPG2 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    COPG2_HUMAN, Q9UBF2: Cytoplasm, cytosol (By similarity). Golgi apparatus membrane; Peripheral membrane protein;
    Cytoplasmic side (By similarity). Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein;
    Cytoplasmic side (By similarity). Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the
    Golgi, as well as on the vesicles/buds originating from it (By similarity). Tends to be more abundant in the
    trans-Golgi network compared to the cis-Golgi (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    cytosol3
    nucleus2
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IEA--
    GO:0030117membrane coat ----
    GO:0030126COPI vesicle coat IDA11056392

    Find genes that share ontologies with COPG2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for COPG2 About    
    See pathways by source

    SuperPathContained pathways About
    1Clathrin dependent protein traffic
    Clathrin dependent protein traffic0.66
    wtCFTR and delta508 CFTR traffic Generic schema norm and CF 0.37
    Transport Clathrin coated vesicle cycle0.66
    2ER to Golgi Transport
    Delta508 CFTR traffic ER to Golgi in CF0.36
    Normal wtCFTR traffic ER to Golgi 0.36
    3G protein signaling RAC1 in cellular process
    Cytoskeleton remodeling CDC42 in cellular processes0.37
    4COPI Mediated Transport
    Cholesterol and Sphingolipids transport Transport from Golgi and ER to the apical membrane normal and CF 0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected GeneGo (Thomson Reuters) Pathways for COPG2 (see all 6)
        wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
    Delta508-CFTR traffic / ER-to-Golgi in CF
    Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF)
    Normal wtCFTR traffic / ER-to-Golgi
    Cytoskeleton remodeling CDC42 in cellular processes


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for COPG2
    Interactions:

        Search GeneGlobe Interaction Network for COPG2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for COPG2 (Q9UBF22, 3 ENSP000003939124) via UniProtKB, MINT, STRING, and/or I2D (see all 943)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COPB1P536182, 3, ENSP000002499234MINT-7945693 MINT-7947479 I2D: score=7 STRING: ENSP00000249923
    ARCN1P484442, 3, ENSP000002640284MINT-7945693 MINT-7947479 I2D: score=6 STRING: ENSP00000264028
    COPAP536212, 3, ENSP000003570484MINT-7945693 MINT-7947479 I2D: score=5 STRING: ENSP00000357048
    EIF3IQ133472, 3, ENSP000003626884MINT-7945693 MINT-7947479 I2D: score=4 STRING: ENSP00000362688
    COPG1Q9Y6782, 3, ENSP000003250024MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000325002
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0006890retrograde vesicle-mediated transport, Golgi to ER TAS11030615
    GO:0006891intra-Golgi vesicle-mediated transport IDA11056392
    GO:0016192vesicle-mediated transport ----

    Find genes that share ontologies with COPG2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for COPG2

    1 HMDB Compound for COPG2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for COPG2 gene (2 alternative transcripts): 
    NM_001290033.1  NM_012133.5  

    Unigene Cluster for COPG2:

    Coatomer protein complex, subunit gamma 2
    Hs.6421  [show with all ESTs]
    Unigene Representative Sequence: NM_012133
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000425248(uc003vqh.1) ENST00000490070 ENST00000330992 ENST00000445977

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    hsa-miR-4314 hsa-miR-548t hsa-miR-3662 hsa-miR-548c-3p hsa-miR-646
    SwitchGear 3'UTR luciferase reporter plasmidCOPG2 3' UTR sequence
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    Additional mRNA sequence: 

    AB047847.1 AF157833.1 AF207598.1 AF308295.1 AK002086.1 AK022934.1 AK024414.1 AK291409.1 
    AL162012.1 BC017443.1 BC110796.1 

    9 DOTS entries:

    DT.95328531  DT.95094686  DT.114640  DT.100764935  DT.409575  DT.92425799  DT.100044641  DT.95271164 
    DT.121100561 

    Selected AceView cDNA sequences (see all 91):

    BU952531 BU501717 BQ949550 BQ286198 AA774034 AF294347 BI222381 BQ269562 
    BE255440 BU689642 CR593178 BQ049150 AW779612 AF431815 BI826509 BU621332 
    AL528440 AI190158 BM714405 BE253295 BE256412 AW469650 AU128587 AA603481 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    COPG2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    COPG2 Expression
    About this image

    COPG2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    COPG2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.6421
        Custom PCR Arrays for COPG2
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for COPG2 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Copg21 , 5 coatomer protein complex, subunit gamma 21, 5 91.01(n)1
    97.59(a)1
      6 (12.54 cM)5
    541601  NM_017478.31  NP_059506.11 
     308584275 
    chicken
    (Gallus gallus)
    Aves COPG21 coatomer protein complex, subunit gamma 2 81.52(n)
    93.8(a)
      416685  XM_414981.4  XP_414981.2 
    lizard
    (Anolis carolinensis)
    Reptilia COPG26
    coatomer protein complex, subunit gamma 2
    27(a)
    1 ↔ 1
    GL343728.1(240642-275884)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia copg21 coatomer protein complex, subunit gamma 2 78.15(n)
    90.01(a)
      493381  NM_001008018.1  NP_001008019.1 
    zebrafish
    (Danio rerio)
    Actinopterygii copg21 coatomer protein complex, subunit gamma 2 76.5(n)
    88.63(a)
      30187  NM_130994.1  NP_571069.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta gammaCop1 , 3 retrograde (Golgi to ER) transport3
    gamma-coatomer protein1
    59(a)3
    57.74(n)1
    60.25(a)1
      100C63
    437171  NM_079869.31  NP_524608.11 
    worm
    (Caenorhabditis elegans)
    Secernentea T14G10.51 , 3 protein transport protein3
    T14G10.51
    55(a)3
    57.22(n)1
    56.45(a)1
      IV(10152526-10155606)3
    1778911  NM_001268535.11  NP_001255464.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SEC211 SEC21 47.96(n)
    39.31(a)
      855429   NP_014112.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G344501 AT4G34450 57.67(n)
    54.09(a)
      829596  NM_119610.3  NP_195171.2 
    rice
    (Oryza sativa)
    Liliopsida Os03g02270001 Os03g0227000 55.95(n)
    53.74(a)
      4332129  NM_001055978.1  NP_001049443.1 


    ENSEMBL Gene Tree for COPG2 (if available)
    TreeFam Gene Tree for COPG2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for COPG2 gene
    COPG12  
    3 SIMAP similar genes for COPG2 using alignment to 5 protein entries:     COPG2_HUMAN (see all proteins):
    DKFZp761N09121    COPG1    COPG

    Find genes that share paralogs with COPG2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for COPG2 (see all 2016)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1455366301,2
    --124579383(+) TCAGGA/GGCCAA 1 -- int10--------
    rs3714452681,2
    C--124582390(+) GCCAAA/GCATGA 1 -- int10--------
    rs1807149951,2
    C--124582666(+) CTACTA/TTAAAG 1 -- int10--------
    rs1511001291,2
    C--124584460(+) GAGCGA/GGACTC 1 -- int10--------
    rs1870791491,2
    C--124592296(+) CTCTGC/TCCGGC 1 -- int10--------
    rs755016351,2
    F--129532068(+) AAAGTA/GAGGAA 1 -- int10--------
    rs132345671,2
    H--129532075(+) GGAAAA/CCCATA 1 -- int14Minor allele frequency- C:0.00NS EA 416
    rs1416760331,2
    C,F--129532085(+) ATTAAG/CAACCC 1 -- int11Minor allele frequency- C:0.00EU 591
    rs23028251,2
    C,F,H--129532424(+) AATGGG/CATGAT 1 -- int16Minor allele frequency- C:0.06EA NS 2034
    rs18051661,2
    C--129532533(-) CATTCG/ACTCTA 2 /S syn11Minor allele frequency- A:0.00EU 569

    HapMap Linkage Disequilibrium report for COPG2 (130146079 - 130353598 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for COPG2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831131CNV Loss17160897
    nsv831130CNV Loss17160897
    nsv831132CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing COPG2
    DNA2.0 Custom Variant and Variant Library Synthesis for COPG2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604355    OMIM disorders: --

    2 diseases from the University of Copenhagen DISEASES database for COPG2:
    Silver-Russell syndrome     Splenic marginal zone lymphoma

    Find genes that share disorders with COPG2           About GenesLikeMe


    Export disorders for COPG2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for COPG2 gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with COPG2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Gamma2-COP, a novel imprinted gene on chromosome 7q32, defines a new imprinting cluster in the human genome. (PubMed id 10556286)1, 2, 3 Blagitko N.... Kalscheuer V.M. (Hum. Mol. Genet. 1999)
    2. The novel gene, gamma2-COP (COPG2), in the 7q32 imprinted domain escapes genomic imprinting. (PubMed id 10995575)1, 3, 9 Yamasaki K....Kishino T. (Genomics 2000)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    5. Identification and characterization of novel isoforms of COP I subunits. (PubMed id 11056392)1, 2 Futatsumori M.... Nakayama K. (J. Biochem. 2000)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    8. Methylation and expression analyses of the 7q autism susceptibility locus genes MEST , COPG2, and TSGA14 in human and anthropoid primate cortices. (PubMed id 22456293)1 Schneider E....Haaf T. (Cytogenet. Genome Res. 2012)
    9. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C.... Cristea I.M. (Mol. Cell. Proteomics 2012)
    10. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (J. Proteome Res. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26958 HGNC: 2237 AceView: COPG2 Ensembl:ENSG00000158623 euGenes: HUgn26958
    ECgene: COPG2 H-InvDB: COPG2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for COPG2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for COPG2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for COPG2 gene:
    Search GeneIP for patents involving COPG2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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