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COPG1 Gene

protein-coding   GIFtS: 56
GCID: GC03P129056

Coatomer Protein Complex, Subunit Gamma 1

(Previous names: coatomer protein complex, subunit gamma)
(Previous symbol: COPG)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Coatomer Protein Complex, Subunit Gamma 11 2     Coatomer Subunit Gamma-12
COPG1 2 3     gamma-1-COP2
Coat Protein Gamma-Cop1 2     gamma-COP2
Gamma-1-Coat Protein2 3     Gamma-Coat Protein2
Coatomer Protein Complex, Subunit Gamma1     Gamma-1-COP3
Coatomer Subunit Gamma2     

External Ids:    HGNC: 22361   Entrez Gene: 228202   Ensembl: ENSG000001817897   OMIM: 6155255   UniProtKB: Q9Y6783   

Export aliases for COPG1 gene to outside databases

Previous GC identifers: GC03P128969 GC03P128970


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for COPG1 Gene:
COPG1 (coatomer protein complex, subunit gamma 1) is a protein-coding gene. Diseases associated with COPG1 include anorexia nervosa, and cerebritis. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is COPG2.

UniProtKB/Swiss-Prot: COPG1_HUMAN, Q9Y678
Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with
Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the
Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is
essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only
be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins;
the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic
recycling of LDL receptors. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis
by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting
the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis (By
similarity)

Gene Wiki entry for COPG1 (COPG) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_005612.17  
Regulatory elements:
   Search for regulatory transcription factor binding sites for COPG1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): COPG1 promoter sequence
   Search Chromatin IP Primers for COPG1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COPG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21.3   Ensembl cytogenetic band:  3q21.3   HGNC cytogenetic band: 3q21.3

COPG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COPG1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P129056:  view genomic region     (about GC identifiers)

Start:
128,968,449 bp from pter      End:
128,996,616 bp from pter
Size:
28,168 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: COPG1_HUMAN, Q9Y678 (See protein sequence)
Recommended Name: Coatomer subunit gamma-1  
Size: 874 amino acids; 97718 Da
Subunit: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta
subunits. Interacts with ZNF289/ARFGAP2 through its C-terminal appendage domain. Interacts with EGFR upon EGF
treatment; interaction is essential for regulation of EGF-dependent nuclear transport of EGFR by retrograde
trafficking from the Golgi to the ER. Interacts with COPB1. Interacts with TMED10 (via C-terminus). Interacts
with TMED2, TMED3, TMED7 and TMED9
1 PDB 3D structure from and Proteopedia for COPG1:
1R4X (3D)    
Secondary accessions: A8K6M8 B3KMF6 Q54AC4

Explore the universe of human proteins at neXtProt for COPG1: NX_Q9Y678

Explore proteomics data for COPG1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys514, Lys540, Lys572
  • Modification sites at PhosphoSitePlus

  • See COPG1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057212.1  
    ENSEMBL proteins: 
     ENSP00000325002   ENSP00000426457   ENSP00000422478   ENSP00000420916  
    Reactome Protein details: Q9Y678

    COPG1 Human Recombinant Protein Products:

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    LSBio Antibodies in human, mouse, rat for COPG1

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 8):
     IPR011989 ARM-like
     IPR002553 Clathrin/coatomer_adapt-like_N
     IPR017106 Coatomer_gsu
     IPR013041 Coatomer/clathrin_app_Ig-like
     IPR013040 Coatomer_gsu_app_Ig-like-sub

    Graphical View of Domain Structure for InterPro Entry Q9Y678

    ProtoNet protein and cluster: Q9Y678

    1 Blocks protein domain: IPB002553 Adaptin

    UniProtKB/Swiss-Prot: COPG1_HUMAN, Q9Y678
    Similarity: Belongs to the COPG family
    Similarity: Contains 4 HEAT repeats


    COPG1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COPG1_HUMAN, Q9Y678
    Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with
    Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the
    Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is
    essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only
    be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins;
    the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic
    recycling of LDL receptors. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis
    by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting
    the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis (By
    similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0005488binding ----
    GO:0005515protein binding IPI14527956
         
    COPG1 for ontologies           About GeneDecksing


    Phenotypes:
         15 GenomeRNAi human phenotypes for COPG1:
     Decreased Hepatitis C virus re  Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica  
     Decreased Salmonella enterica   Decreased Salmonella-containin  Decreased Wnt reporter activit  Decreased cell number, increas 
     Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/  Decreased influenza A virus in  Decreased influenza A/WSN/33 r 
     Decreased viability of wild-ty  Increased Salmonella enterica   Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Copg1):
     mortality/aging 

    COPG1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for COPG1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for COPG1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for COPG1

    miRNA
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    miRTarBase miRNAs that target COPG1:
    hsa-let-7e-5p (MIRT051586), hsa-mir-1 (MIRT023687), hsa-mir-92a-3p (MIRT049305), hsa-let-7b-5p (MIRT032263), hsa-mir-1296-5p (MIRT036123), hsa-mir-335-5p (MIRT017439)

    Block miRNA regulation of human, mouse, rat COPG1 using miScript Target Protectors
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    SwitchGear 3'UTR luciferase reporter plasmidCOPG1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPG1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    COPG1_HUMAN, Q9Y678: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.
    Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity).
    Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the
    vesicles/buds originating from it (By similarity). Predominantly located in the cis-Golgi apparatus (By
    similarity)

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane ISS--
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005794Golgi apparatus ----
    GO:0005829cytosol TAS--

    COPG1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for COPG1 About    
    See pathways by source

    SuperPathContained pathways About
    1Clathrin dependent protein traffic
    Clathrin dependent protein traffic0.66
    wtCFTR and delta508 CFTR traffic Generic schema norm and CF 0.37
    Transport Clathrin coated vesicle cycle0.66
    2COPI Mediated Transport
    COPI Mediated Transport0.31
    Golgi to ER Retrograde Transport0.00
    Cholesterol and Sphingolipids transport Transport from Golgi and ER to the apical membrane normal and CF 0.31
    3ER to Golgi Transport
    Delta508 CFTR traffic ER to Golgi in CF0.36
    Normal wtCFTR traffic ER to Golgi 0.36
    4Clathrin derived vesicle budding
    Membrane Trafficking0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5 GeneGo (Thomson Reuters) Pathways for COPG1
        wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
    Delta508-CFTR traffic / ER-to-Golgi in CF
    Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF)
    Normal wtCFTR traffic / ER-to-Golgi
    Transport Clathrin-coated vesicle cycle


    1 Reactome Pathway for COPG1
        COPI Mediated Transport



    COPG1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for COPG1
    Interactions:

        Search GeneGlobe Interaction Network for COPG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for COPG1 (Q9Y6781, 2, 3 ENSP000003250024) via UniProtKB, MINT, STRING, and/or I2D (see all 942)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COPB1P536182, 3, ENSP000002499234MINT-7945693 MINT-8217717 MINT-7947479 I2D: score=2 STRING: ENSP00000249923
    ARCN1P484442, 3, ENSP000002640284MINT-7945693 MINT-8217717 MINT-7947479 I2D: score=1 STRING: ENSP00000264028
    COPB2P356062, 3, ENSP000003294194MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000329419
    COPEO145792, 3, ENSP000002628124MINT-8217717 I2D: score=2 STRING: ENSP00000262812
    H2AFXP161042, 3, ENSP000003643104MINT-8257911 I2D: score=2 STRING: ENSP00000364310
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0006890retrograde vesicle-mediated transport, Golgi to ER TAS--
    GO:0016192vesicle-mediated transport ----
    GO:0048205COPI coating of Golgi vesicle TAS--
    GO:0051683establishment of Golgi localization ISS--

    COPG1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for COPG1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for COPG1 gene: 
    NM_016128.3  

    Unigene Cluster for COPG1:

    Coatomer protein complex, subunit gamma 1
    Hs.518250  [show with all ESTs]
    Unigene Representative Sequence: AK309821
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000314797(uc003els.3) ENST00000513965 ENST00000515725(uc010htb.3)
    ENST00000504350 ENST00000509208 ENST00000504547 ENST00000513410 ENST00000509889
    ENST00000514478 ENST00000512034
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat COPG1
      QuantiFast Probe-based Assays in human, mouse, rat COPG1

    Additional mRNA sequence: 

    AB047846.1 AF100756.1 AK001724.1 AK024721.1 AK025147.1 AK123939.1 AK291693.1 AK309821.1 
    BC020498.1 BC066650.1 

    Selected DOTS entries (see all 27):

    DT.455897  DT.95214786  DT.100867033  DT.100661902  DT.95256084  DT.120857634  DT.120857671  DT.97854965 
    DT.100642880  DT.100661903  DT.120857834  DT.87015641  DT.92039405  DT.95256114  DT.100661901  DT.103151 
    DT.120857560  DT.120857637  DT.120857651  DT.120857769  DT.120857805  DT.86994889  DT.91668564  DT.91793454 

    Selected AceView cDNA sequences (see all 450):

    BX340734 BU857390 AI082780 CF593680 BE784423 BG767641 BI333789 CB145105 
    BI518771 AI754144 BE560214 AW949278 BM453251 BM556590 BM739618 AW602534 
    BM472575 AL600878 BM750281 BE550081 AI338190 N35983 BQ228910 BP373670 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for COPG1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^
    SP1:                          -                                                                 -                                               -               
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                          -                                                                                                                                 

    ExUns: 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b
    SP1:                          -                           
    SP2:                                                      
    SP3:                                                      
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for COPG1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    COPG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTTATTGA
    COPG1 Expression
    About this image


    COPG1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Kidney (Urinary System)
             Metanephros
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Bone (Muscoskeletal System)
             Mandibular Condyle
    COPG1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    COPG1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.518250
        Custom PCR Arrays for COPG1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPG1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for COPG1 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Copg11 , 5 coatomer protein complex, subunit gamma5
    coatomer protein complex, subunit gamma 11
    89.17(n)1
    97.25(a)1
      6 (39.13 cM)5
    541611  NM_017477.21  NP_059505.11 
     878878145 
    chicken
    (Gallus gallus)
    Aves COPG1 coatomer protein complex, subunit gamma 82.07(n)
    93.36(a)
      416014  NM_001030597.1  NP_001025768.1 
    lizard
    (Anolis carolinensis)
    Reptilia COPG16
    coatomer protein complex, subunit gamma 1
    82(a)
    1 ↔ 1
    2(164652192-164683415)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC685332 hypothetical protein MGC68533 76.62(n)    BC061661.1 
    zebrafish
    (Danio rerio)
    Actinopterygii copg22 coatomer protein complex, subunit gamma 2 77.18(n)   30187  AF191561.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta gammaCop6
    gamma-coatomer protein
    59(a)
    1 → many
    3R(27397865-27401429)
    worm
    (Caenorhabditis elegans)
    Secernentea T14G10.56
    Protein T14G10.5, isoform a (T14G10.5) mRNA, compl...
    52(a)
    1 → many
    IV(10151949-10155637) WBGene00011775
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SEC21(YNL287W)4 Gamma subunit of coatomer, a heptameric protein complex more   --   14(91994-94801) 855429  NP_014112.1 
    rice
    (Oryza sativa)
    Liliopsida Os.79842 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 71.95(n)    AK100095.1 


    ENSEMBL Gene Tree for COPG1 (if available)
    TreeFam Gene Tree for COPG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for COPG1 gene
    COPG22  
    3 SIMAP similar genes for COPG1 using alignment to 4 protein entries:     COPG1_HUMAN (see all proteins):
    COPG    COPG2    DKFZp761N09121

    COPG1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for COPG1 (see all 748)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1386945001,2
    --128966461(+) GCCTTC/GACCTC 1 -- us2k10--------
    rs68034041,2
    C,F,A--128966479(+) taagcA/Gatcct 1 -- us2k19Minor allele frequency- G:0.33NA WA CSA 251
    rs1890032621,2
    --128966669(+) CGCTTC/TTGTTG 1 -- us2k10--------
    rs563653311,2
    C--128966766(+) CCTCCC/TGAGTA 1 -- us2k10--------
    rs610569821,2
    C,F--128966767(+) CTCCCA/GAGTAG 1 -- us2k12Minor allele frequency- G:0.33NA CSA 3
    rs611855431,2
    C,F--128966896(+) CACCTA/GCCTCA 1 -- us2k12Minor allele frequency- G:0.33NA CSA 3
    rs1926800541,2
    --128966918(+) TGCTGG/TGATTA 1 -- us2k10--------
    rs1493766411,2
    --128966940(+) CACTGC/TGCCCG 1 -- us2k10--------
    rs76257041,2
    C,F--128966941(+) actgcG/Acccgg 1 -- us2k13Minor allele frequency- A:0.37WA CSA 121
    rs603178031,2
    C,F--128966997(+) GTTACC/TGATCA 1 -- us2k15Minor allele frequency- T:0.17WA NA CSA 243

    HapMap Linkage Disequilibrium report for COPG1 (128968449 - 128996616 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for COPG1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing COPG1
    DNA2.0 Custom Variant and Variant Library Synthesis for COPG1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615525    OMIM disorders: --

    3 diseases for COPG1:    
    About MalaCards
    anorexia nervosa    cerebritis    neuronitis


    COPG1 for disorders           About GeneDecksing


    Export disorders for COPG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for COPG1 gene, integrated from 10 sources (see all 55):
    (articles sorted by number of sources associating them with COPG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of novel isoforms of COP I subunits. (PubMed id 11056392)1, 2, 3 Futatsumori M.... Nakayama K. (J. Biochem. 2000)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Gamma-COP appendage domain -- structure and function. (PubMed id 14690497)1, 2 Watson P.J.... Owen D.J. (Traffic 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    6. A Proteomics Strategy for the Identification of FAT10-Modified Sites by Mass Spectrometry. (PubMed id 23862649)1 Leng L....Wang J. (J. Proteome Res. 2014)
    7. Quantitative study of the interactome of PKCIP involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)1 Chen R....Zhang N. (J. Proteome Res. 2013)
    8. Golgi-situated endoplasmic reticulum I+-1, 2-mannosidase contributes to the retrieval of ERAD substrates through a direct interaction with I^-COP. (PubMed id 23427261)1 Pan S....Sifers R.N. (Mol. Biol. Cell 2013)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 22820 HGNC: 2236 AceView: COPG Ensembl:ENSG00000181789 euGenes: HUgn22820
    ECgene: COPG1 H-InvDB: COPG1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for COPG1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for COPG1 gene:
    Search GeneIP for patents involving COPG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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