Free for academic non-profit institutions. Other users need a Commercial license

Aliases for COPG1 Gene

Aliases for COPG1 Gene

  • Coatomer Protein Complex, Subunit Gamma 1 2 3
  • Coat Protein Gamma-Cop 2 3
  • Gamma-1-Coat Protein 3 4
  • Gamma-1-COP 3 4
  • COPG 3 4
  • Coatomer Protein Complex, Subunit Gamma 2
  • Coatomer Subunit Gamma-1 3
  • Coatomer Subunit Gamma 3
  • Gamma-Coat Protein 3
  • Gamma-COP 3

External Ids for COPG1 Gene

Previous Symbols for COPG1 Gene

  • COPG

Summaries for COPG1 Gene

GeneCards Summary for COPG1 Gene

COPG1 (Coatomer Protein Complex, Subunit Gamma 1) is a Protein Coding gene. Among its related pathways are COPI Mediated Transport and COPI Mediated Transport. GO annotations related to this gene include structural molecule activity.

UniProtKB/Swiss-Prot for COPG1 Gene

  • The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis (By similarity).

Gene Wiki entry for COPG1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COPG1 Gene

Genomics for COPG1 Gene

Genomic Location for COPG1 Gene

Start:
129,249,606 bp from pter
End:
129,277,773 bp from pter
Size:
28,168 bases
Orientation:
Plus strand

Genomic View for COPG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COPG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COPG1 Gene

No data available for Regulatory Elements for COPG1 Gene

Proteins for COPG1 Gene

  • Protein details for COPG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y678-COPG1_HUMAN
    Recommended name:
    Coatomer subunit gamma-1
    Protein Accession:
    Q9Y678
    Secondary Accessions:
    • A8K6M8
    • B3KMF6
    • Q54AC4

    Protein attributes for COPG1 Gene

    Size:
    874 amino acids
    Molecular mass:
    97718 Da
    Quaternary structure:
    • Oligomeric complex that consists of at least the alpha, beta, beta, gamma, delta, epsilon and zeta subunits. Interacts with ZNF289/ARFGAP2 through its C-terminal appendage domain. Interacts with EGFR upon EGF treatment; interaction is essential for regulation of EGF-dependent nuclear transport of EGFR by retrograde trafficking from the Golgi to the ER. Interacts with COPB1. Interacts with TMED10 (via C-terminus). Interacts with TMED2, TMED3, TMED7 and TMED9.

    Three dimensional structures from OCA and Proteopedia for COPG1 Gene

neXtProt entry for COPG1 Gene

Proteomics data for COPG1 Gene at MOPED

Post-translational modifications for COPG1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys514, Lys540, and Lys572

Other Protein References for COPG1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for COPG1 Gene

Domains for COPG1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y678

UniProtKB/Swiss-Prot:

COPG1_HUMAN
Family:
  • Belongs to the COPG family.:
    • Q9Y678
Similarity:
  • Contains 4 HEAT repeats.:
    • Q9Y678
genes like me logo Genes that share domains with COPG1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for COPG1 Gene

Function for COPG1 Gene

Molecular function for COPG1 Gene

UniProtKB/Swiss-Prot Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis (By similarity).

Gene Ontology (GO) - Molecular Function for COPG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005488 binding --
GO:0005515 protein binding IPI 14527956
genes like me logo Genes that share ontologies with COPG1: view
genes like me logo Genes that share phenotypes with COPG1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for COPG1 Gene

Localization for COPG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COPG1 Gene

Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Predominantly located in the cis-Golgi apparatus. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for COPG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane ISS --
GO:0005829 cytosol TAS --
GO:0030117 membrane coat --
GO:0030126 COPI vesicle coat ISS --
genes like me logo Genes that share ontologies with COPG1: view

No data available for Subcellular locations from COMPARTMENTS for COPG1 Gene

Pathways for COPG1 Gene

genes like me logo Genes that share pathways with COPG1: view

Gene Ontology (GO) - Biological Process for COPG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS --
GO:0016192 vesicle-mediated transport --
GO:0048205 COPI coating of Golgi vesicle TAS --
GO:0051683 establishment of Golgi localization ISS --
genes like me logo Genes that share ontologies with COPG1: view

Transcripts for COPG1 Gene

Unigene Clusters for COPG1 Gene

Coatomer protein complex, subunit gamma 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COPG1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^
SP1: - - -
SP2:
SP3:
SP4:
SP5: -
SP6:

ExUns: 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for COPG1 Gene

GeneLoc Exon Structure for
COPG1
ECgene alternative splicing isoforms for
COPG1

Expression for COPG1 Gene

mRNA expression in normal human tissues for COPG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COPG1 Gene

SOURCE GeneReport for Unigene cluster for COPG1 Gene Hs.518250

genes like me logo Genes that share expressions with COPG1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for COPG1 Gene

Orthologs for COPG1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for COPG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COPG1 35
  • 99.54 (n)
  • 99.77 (a)
COPG1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia COPG1 35
  • 88.63 (n)
  • 97.25 (a)
COPG1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COPG1 35
  • 92.6 (n)
  • 98.63 (a)
COPG1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Copg1 35
  • 89.17 (n)
  • 97.25 (a)
Copg1 16
Copg1 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia COPG1 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COPG1 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Copg1 35
  • 89.32 (n)
  • 97.14 (a)
chicken
(Gallus gallus)
Aves COPG 35
  • 82.07 (n)
  • 93.36 (a)
COPG 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COPG1 36
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68533 35
tropical clawed frog
(Silurana tropicalis)
Amphibia copg1 35
  • 77.73 (n)
  • 89.13 (a)
MGC76032 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13885 35
zebrafish
(Danio rerio)
Actinopterygii copg2 35
fruit fly
(Drosophila melanogaster)
Insecta gammaCop 36
  • 59 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T14G10.5 36
  • 52 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC21 36
  • 29 (a)
OneToMany
SEC21 38
rice
(Oryza sativa)
Liliopsida Os.7984 35
wheat
(Triticum aestivum)
Liliopsida Ta.14195 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4468 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 60 (a)
ManyToMany
CSA.452 36
  • 72 (a)
ManyToMany
Species with no ortholog for COPG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for COPG1 Gene

ENSEMBL:
Gene Tree for COPG1 (if available)
TreeFam:
Gene Tree for COPG1 (if available)

Paralogs for COPG1 Gene

Selected SIMAP similar genes for COPG1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with COPG1: view

No data available for Paralogs for COPG1 Gene

Variants for COPG1 Gene

Sequence variations from dbSNP and Humsavar for COPG1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs4927906 -- 129,260,265(-) GGGCT(A/G)CTGTT intron-variant
rs4927907 -- 129,260,221(-) GCTGA(C/T)ACCCC intron-variant
rs4927910 -- 129,257,553(-) AGGCC(A/G)TGCCG synonymous-codon, reference
rs4927911 -- 129,255,141(-) AATGT(A/G)ACTCT intron-variant
rs4927912 -- 129,255,135(-) ACTCT(C/G/T)AAATT intron-variant

Relevant External Links for COPG1 Gene

HapMap Linkage Disequilibrium report
COPG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for COPG1 Gene

Disorders for COPG1 Gene

No disorders were found for COPG1 Gene.

No data available for UniProtKB/Swiss-Prot for COPG1 Gene

Publications for COPG1 Gene

  1. Identification and characterization of novel isoforms of COP I subunits. (PMID: 11056392) Futatsumori M. … Nakayama K. (J. Biochem. 2000) 2 3 4
  2. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  3. Gamma-COP appendage domain -- structure and function. (PMID: 14690497) Watson P.J. … Owen D.J. (Traffic 2004) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for COPG1 Gene

Sources for COPG1 Gene

Back to Top

Content