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COPE Gene

protein-coding   GIFtS: 63
GCID: GC19M019010

Coatomer Protein Complex, Subunit Epsilon

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Coatomer Protein Complex, Subunit Epsilon1 2     Epsilon Coat Protein2
Epsilon-Coat Protein2 3     epsilon-COP2
Coatomer Epsilon Subunit2     Epsilon-COP3
Coatomer Subunit Epsilon2     

External Ids:    HGNC: 22341   Entrez Gene: 113162   Ensembl: ENSG000001056697   OMIM: 6069425   UniProtKB: O145793   

Export aliases for COPE gene to outside databases

Previous GC identifers: GC19M019504 GC19M019402 GC19M018855 GC19M018871 GC19M018574


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for COPE Gene:
The product of this gene is an epsilon subunit of coatomer protein complex. Coatomer is a cytosolic protein
complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. It is
required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of
dilysine-tagged proteins. Coatomer complex consists of at least the alpha, beta, beta', gamma, delta, epsilon and
zeta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified.
(provided by RefSeq, Jul 2008)

GeneCards Summary for COPE Gene:
COPE (coatomer protein complex, subunit epsilon) is a protein-coding gene. GO annotations related to this gene include structural molecule activity.

UniProtKB/Swiss-Prot: COPE_HUMAN, O14579
Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with
Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the
Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is
essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only
be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins;
the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic
recycling of LDL receptors (By similarity)

Gene Wiki entry for COPE Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the COPE gene promoter:
         AhR   ER-alpha   AML1a   Bach2   MyoD   Lmo2   CUTL1   Nkx2-5   HEN1   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOPE promoter sequence
   Search Chromatin IP Primers for COPE

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COPE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.11

COPE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COPE gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M019010:  view genomic region     (about GC identifiers)

Start:
19,010,323 bp from pter      End:
19,030,206 bp from pter
Size:
19,884 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: COPE_HUMAN, O14579 (See protein sequence)
Recommended Name: Coatomer subunit epsilon  
Size: 308 amino acids; 34482 Da
Subunit: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta
subunits
Secondary accessions: A6NE29 A6NKA3 O76097 Q6IBB8 Q9UGP6
Alternative splicing: 3 isoforms:  O14579-1   O14579-2   O14579-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for COPE: NX_O14579

Explore proteomics data for COPE at MOPED

Post-translational modifications: 

  • Phosphorylated by PKA1
  • Polyubiquitinated by RCHY1 in the presence of androgen, leading to proteasomal degradation1
  • Ubiquitination2 at Lys65, Lys265, Lys278
  • Modification sites at PhosphoSitePlus

  • See COPE Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_009194.2  NP_955474.1  NP_955476.1  

    ENSEMBL proteins: 
     ENSP00000262812   ENSP00000343134   ENSP00000469035   ENSP00000345674   ENSP00000471034  
    Reactome Protein details: O14579

    COPE Human Recombinant Protein Products:

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    Novus Biologicals COPE Proteins
    Novus Biologicals COPE Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for COPE 

     
    antibodies-online proteins for COPE (6 products) 

     
    antibodies-online peptides for COPE

    COPE Antibody Products:

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    antibodies-online antibodies for COPE (19 products) 

    COPE Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for COPE 
    antibodies-online kits for COPE (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR006822 Coatomer_esu

    Graphical View of Domain Structure for InterPro Entry O14579

    ProtoNet protein and cluster: O14579

    1 Blocks protein domain: IPB006822 Coatomer epsilon subunit

    UniProtKB/Swiss-Prot: COPE_HUMAN, O14579
    Similarity: Belongs to the COPE family


    Find genes that share domains with COPE           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COPE_HUMAN, O14579
    Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with
    Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the
    Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is
    essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only
    be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins;
    the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic
    recycling of LDL receptors (By similarity)

         Genatlas biochemistry entry for COPE:
    Golgi coatomer complex,epsilon subunit,component of the coat of non clathrin-coated vesicles,involved in the
    transport between endoplasmic reticulum and Golgi

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
         
    Find genes that share ontologies with COPE           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for COPE:
     Decreased circadian period len  Decreased influenza A/WSN/33 r 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for COPE

    miRNA
    Products:
        
    miRTarBase miRNAs that target COPE:
    hsa-mir-106b-3p (MIRT038601), hsa-mir-1301-3p (MIRT035993), hsa-mir-345-5p (MIRT042729)

    Block miRNA regulation of human, mouse, rat COPE using miScript Target Protectors
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    GenScript: all cDNA clones in your preferred vector (see all 3): COPE (NM_007263)
    Sino Biological Human cDNA Clone for COPE
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COPE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COPE
    Addgene plasmids for COPE 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    COPE_HUMAN, O14579: Cytoplasm (By similarity). Golgi apparatus membrane; Peripheral membrane protein;
    Cytoplasmic side (By similarity). Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein;
    Cytoplasmic side (By similarity). Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the
    Golgi, as well as on the vesicles/buds originating from it (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    cytosol4
    endoplasmic reticulum2
    nucleus2
    endosome1
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005829cytosol TAS--
    GO:0030126COPI vesicle coat ISS--

    Find genes that share ontologies with COPE           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for COPE About    
    See pathways by source

    SuperPathContained pathways About
    1Clathrin dependent protein traffic
    Clathrin dependent protein traffic0.66
    wtCFTR and delta508 CFTR traffic Generic schema norm and CF 0.37
    Transport Clathrin coated vesicle cycle0.66
    2COPI Mediated Transport
    COPI Mediated Transport0.31
    Golgi to ER Retrograde Transport0.00
    Cholesterol and Sphingolipids transport Transport from Golgi and ER to the apical membrane normal and CF 0.31
    3ER to Golgi Transport
    Delta508 CFTR traffic ER to Golgi in CF0.36
    Normal wtCFTR traffic ER to Golgi 0.36
    4Clathrin derived vesicle budding
    Membrane Trafficking0.32


    Find genes that share SuperPaths with COPE           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5 GeneGo (Thomson Reuters) Pathways for COPE
        wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
    Delta508-CFTR traffic / ER-to-Golgi in CF
    Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF)
    Normal wtCFTR traffic / ER-to-Golgi
    Transport Clathrin-coated vesicle cycle


    1 Reactome Pathway for COPE
        COPI Mediated Transport


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for COPE
    Interactions:

        Search GeneGlobe Interaction Network for COPE

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for COPE (O145792, 3 ENSP000002628124) via UniProtKB, MINT, STRING, and/or I2D (see all 128)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COPG1Q9Y6782, 3, ENSP000003250024MINT-8217717 I2D: score=2 STRING: ENSP00000325002
    COPAP536212, 3, ENSP000003570484MINT-8217717 MINT-63065 I2D: score=7 STRING: ENSP00000357048
    COPB1P536182, 3, ENSP000002499234MINT-8217717 I2D: score=2 STRING: ENSP00000249923
    ARF1P840773, ENSP000002721024I2D: score=2 STRING: ENSP00000272102
    CASP4P496623, ENSP000003885664I2D: score=1 STRING: ENSP00000388566
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006890retrograde vesicle-mediated transport, Golgi to ER TAS--
    GO:0006891intra-Golgi vesicle-mediated transport ISS--
    GO:0015031protein transport IEA--
    GO:0048205COPI coating of Golgi vesicle TAS--
    GO:0061024membrane organization TAS--

    Find genes that share ontologies with COPE           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for COPE

    1 HMDB Compound for COPE    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for COPE gene (3 alternative transcripts): 
    NM_007263.3  NM_199442.1  NM_199444.1  

    Unigene Cluster for COPE:

    Coatomer protein complex, subunit epsilon
    Hs.10326  [show with all ESTs]
    Unigene Representative Sequence: AK023303
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000600528 ENST00000262812(uc002nkk.3) ENST00000349893(uc002nkm.3)
    ENST00000595984 ENST00000600932 ENST00000598969 ENST00000351079(uc002nkl.3)
    ENST00000593827 ENST00000597026 ENST00000597646 ENST00000599964
    miRNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COPE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COPE
    Addgene plasmids for COPE 
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    OriGene qPCR primer pairs and template standards for COPE
    OriGene qSTAR qPCR primer pairs in human, mouse for COPE
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat COPE
      QuantiTect SYBR Green Assays in human, mouse, rat COPE
      QuantiFast Probe-based Assays in human, mouse, rat COPE

    Additional mRNA sequence: 

    AF092438.1 AJ131182.1 AJ249366.1 AK023303.1 AK222584.1 AK315281.1 AL136928.1 BC003155.1 
    BC007250.1 BC017285.2 CR456886.1 

    Selected DOTS entries (see all 34):

    DT.102834041  DT.101985496  DT.97855884  DT.87003725  DT.100018835  DT.100038972  DT.100874709  DT.91813779 
    DT.95204732  DT.92066964  DT.102834040  DT.100841206  DT.100874690  DT.100874695  DT.97834998  DT.100874696 
    DT.121497850  DT.100874699  DT.121497955  DT.95204658  DT.100038974  DT.100874697  DT.100874700  DT.100874703 

    Selected AceView cDNA sequences (see all 1024):

    BM824906 CR614529 BI818385 CR597570 BU627722 BM769207 CB129983 BU196580 
    BM844296 BM794754 BQ950009 BM769257 CF128343 BQ007573 BU849879 CA488192 
    BM768349 BM845687 BG677919 CR614039 BQ684036 BM842638 BM846442 BM798704 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for COPE (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d · 11e
    SP1:                                      -     -     -                                                                           
    SP2:                                      -           -                                                                           
    SP3:                                                  -                                                                           
    SP4:                                                                                                                              
    SP5:                                                                    -                                                         


    ECgene alternative splicing isoforms for COPE

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    COPE expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCCAGGAC
    COPE Expression
    About this image


    COPE expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Bone (Muscoskeletal System)
             Bone Marrow
    COPE Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    COPE Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.10326
        Custom PCR Arrays for COPE
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat COPE
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPE

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for COPE gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cope1 , 5 coatomer protein complex, subunit epsilon1, 5 85.28(n)1
    90.58(a)1
      8 (34.15 cM)5
    590421  NM_021538.11  NP_067513.11 
     703025185 
    chicken
    (Gallus gallus)
    Aves COPE1 coatomer protein complex, subunit epsilon 73.05(n)
    78.9(a)
      420117  NM_001006339.1  NP_001006339.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia BU152767.12   -- 81.26(n)    BU152767.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.256292 Transcribed sequence with moderate similarity to protein more 75.4(n)    CK352667.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta BcDNA:LD298853
    epsilonCOP1
    retrograde (Golgi to ER) transport3
    epsilonCOP1
    39(a)3
    53.88(n)1
    40.14(a)1
      26D93
    339081  NM_135193.21  NP_609037.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F45G2.41 , 3 F45G2.41 37(a)3
    48.41(n)1
    37.46(a)1
      III(13497638-13498864)3
    1767661  NM_067370.41  NP_499771.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G348401 AT2G34840 48.67(n)
    42.91(a)
      818049  NM_129037.5  NP_181030.1 
    rice
    (Oryza sativa)
    Liliopsida Os04g06126001 Os04g0612600 52.59(n)
    44.4(a)
      4336967  NM_001060382.1  NP_001053847.1 


    ENSEMBL Gene Tree for COPE (if available)
    TreeFam Gene Tree for COPE (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for COPE (see all 410)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs37610841,2
    C,F--19009825(-) GAGGCG/AGCCGC 3 -- ds50016Minor allele frequency- A:0.25NA WA EA 364
    rs1833009901,2
    --19009899(+) TTTGCA/GGGGCG 3 -- ds50010--------
    rs556890081,2
    C,F--19010045(+) CCTCAC/TGATAG 3 -- ds50011Minor allele frequency- T:0.50WA 2
    rs1136879541,2
    C--19010083(+) CCCCCG/-ATGCC 3 -- ds50011Minor allele frequency- -:0.50CSA 2
    rs1869859111,2
    --19010299(+) GCCCCC/GAGCAA 3 -- ds50010--------
    rs10448231,2
    C,F,H--19010394(-) CCCCTC/TTGGGG 3 -- ut31 ese35Minor allele frequency- T:0.01MN NS NA 696
    rs1498541081,2
    C--19010494(+) CAGGCG/ACTGGG 6 /S syn11Minor allele frequency- A:0.00NA 4542
    rs1997316611,2
    C,F--19010541(+) CTTTAG/CCAAGA 3 -- int11Minor allele frequency- C:0.00EU 1321
    rs1131050621,2
    C--19010565(+) AGGGTG/CGGGGC 3 -- int11Minor allele frequency- C:0.50CSA 2
    rs1417726051,2
    C,F--19010712(+) GGATGG/AGACCT 6 /S syn12Minor allele frequency- A:0.00NA EU 5835

    HapMap Linkage Disequilibrium report for COPE (19010323 - 19030206 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for COPE:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833777CNV Loss17160897
    nsv470132CNV Loss18288195
    nsv817819CNV Loss17921354
    dgv3786n71CNV Loss21882294
    dgv3787n71CNV Loss21882294
    nsv833778CNV Loss17160897
    dgv3788n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing COPE
    DNA2.0 Custom Variant and Variant Library Synthesis for COPE

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606942    OMIM disorders: --


    Find genes that share disorders with COPE           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: COPE (22 documents)

    Export disorders for COPE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for COPE gene, integrated from 10 sources (see all 52):
    (articles sorted by number of sources associating them with COPE)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Segregation of COPI-rich and anterograde-cargo-rich domains in endoplasmic-reticulum-to-Golgi transport complexes. (PubMed id 10469566)1, 2, 3 Shima D.T.... Pepperkok R. (Curr. Biol. 1999)
    2. Ubiquitylation of epsilon-COP by PIRH2 and regulation of the secretion of PSA. (PubMed id 17721809)1, 2 Maruyama S.... Hatakeyama S. (Mol. Cell. Biochem. 2008)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    6. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    7. Quantitative study of the interactome of PKCIP involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)1 Chen R....Zhang N. (J. Proteome Res. 2013)
    8. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    9. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11316 HGNC: 2234 AceView: COPE Ensembl:ENSG00000105669 euGenes: HUgn11316
    ECgene: COPE H-InvDB: COPE

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for COPE Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for COPE gene:
    Search GeneIP for patents involving COPE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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