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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

COPB2 Gene

protein-coding GIFtS: 62
GCID: GC03M139076

coatomer protein complex, subunit beta 2 (beta prime)

Explore 10 diseases affiliated with
COPB2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Coatomer Protein Complex, Subunit Beta 2 (Beta Prime)¹ ²		P102¹
Beta'-COP³		Coatomer Binding Complex, Beta Prime Subunit²
Betaprime-COP¹		Coatomer Subunit Beta'²
Beta'-Coat Protein² ³		Beta'-COP³

External Ids:	HGNC: 2232¹	Entrez Gene: 9276²	Ensembl: ENSG00000184432⁷	OMIM: 606990⁵	UniProtKB: P35606³

Export aliases for COPB2 gene to outside databases

Previous GC identifers: GC03U990100 GC03M140357 GC03M140397 GC03M140559 GC03M136451

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for COPB2:

The Golgi coatomer complex (see MIM 601924) constitutes the coat of nonclathrin-coated vesicles and is essential for

Golgi budding and vesicular trafficking. It consists of 7 protein subunits, including COPB2.(supplied by OMIM, Jul

2002)

UniProtKB/Swiss-Prot: COPB2_HUMAN, P35606

Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with

Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up

to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the

retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by

membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also

influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL

receptors (By similarity)

Function: This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding

protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner (By

similarity)

Gene Wiki entry for COPB2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the COPB2 gene promoter:
c-Fos p53 AP-1 ATF-2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: COPB2 promoter sequence

Search SABiosciences Chromatin IP Primers for COPB2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COPB2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q23 Ensembl cytogenetic band: 3q23 HGNC cytogenetic band: 3q23

COPB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COPB2 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M139076: view genomic region (about GC identifiers)

Start:	139,074,442 bp from pter	End:	139,108,574 bp from pter
Size:	34,133 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: COPB2_HUMAN, P35606 (See protein sequence)

Recommended Name: Coatomer subunit beta'

Size: 906 amino acids; 102487 Da

Subunit: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.

Probably interacts with PEX11A. Interacts with SCYL1 (By similarity)

Subcellular location: Cytoplasm (By similarity). Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic

side (By similarity). Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side

(By similarity). Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on

the vesicles/buds originating from it (By similarity)

Explore the universe of human proteins at neXtProt for COPB2: NX_P35606

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P35606

COPB2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004757.1

ENSEMBL proteins:

ENSP00000426682 ENSP00000329419 ENSP00000422295 ENSP00000422917 ENSP00000423271

ENSP00000422547 ENSP00000424144 ENSP00000427185 ENSP00000422469

Reactome Protein details: P35606
Human Recombinant Protein Products:

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	GenScript Custom Purified and Recombinant Proteins Services for COPB2
	Novus Biologicals COPB2 Proteins Novus Biologicals COPB2 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	--
GO:0005794	Golgi apparatus	IDA	--
GO:0005829	cytosol	TAS	--
GO:0015629	actin cytoskeleton	IDA	--
GO:0030117	membrane coat	--	--

COPB2 for ontologies About GeneDecksing

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Assay Products for COPB2:

	Browse Kits and Assays available from EMD Millipore
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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

COPB2 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR006692 Coatomer_WD-assoc_reg

IPR001680 WD40_repeat

IPR020472 G-protein_beta_WD-40_rep

IPR016453 Coatomer_b'su

IPR017986 WD40_repeat_dom

Graphical View of Domain Structure for InterPro Entry P35606

ProtoNet protein and cluster: P35606

2 Blocks protein families:

IPB001680 G-protein beta WD-40 repeat signature

IPB006692 Coatomer WD associated region

UniProtKB/Swiss-Prot: COPB2_HUMAN, P35606

Similarity: Belongs to the WD repeat COPB2 family

Similarity: Contains 9 WD repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: COPB2_HUMAN, P35606

Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with

Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up

to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the

retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by

membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also

influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL

receptors (By similarity)

Function: This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding

protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner (By

Golgi coatomer complex,beta subunit,component of the coat of non clathrin coated vesicles,putatively involved in

regulating membrane trafficking in the exocytic pathway

miRNA Products:		OriGene 3'-UTR Clone: COPB2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COPB2
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate COPB2:
		hsa-miR-3163 hsa-miR-548c-3p
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COPB2 (see all 6) OriGene siRNA: COPB2
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Gene Editing
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DNA2.0 Custom Protein Engineering Service for COPB2

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		GenScript: all cDNA clones in your preferred vector: COPB2 (NM_004766)
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPB2

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005198	structural molecule activity	IEA	--

COPB2 for ontologies About GeneDecksing

15 GenomeRNAi human phenotypes for COPB2:

Decreased Hepatitis C virus re	Decreased Salmonella enterica	Decreased Salmonella enterica	Decreased Salmonella enterica
Decreased Salmonella-containin	Decreased Wnt reporter activit	Decreased cell number, increas	Decreased influenza A H1N1 (A/
Decreased influenza A H1N1 (A/	Decreased influenza A virus in	Decreased influenza A/WSN/33 r	Decreased viability
Decreased viability of wild-ty	G0/1 arrest	Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Coatomer:Arf1-GTP:GAP lattice formation on golgi membrane

Coatomer:Arf1-GTP:GAP lattice formation on golgi membrane	1.00	COPI Mediated Transport	0.90
Hydrolysis of Arf1-GTP to Arf1-GDP	1.00	Golgi vesicle lattice disassociation	0.89
Diffusion of inactive Arf1-GDP from membrane	1.00	Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF)	0.32
Golgi to ER Retrograde Transport	0.90

Clathrin-dependent protein traffic

	Clathrin-dependent protein traffic	1.00			wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)	0.37
	Transport_Clathrin-coated vesicle cycle	0.66

COPII (Coat Protein 2) Mediated Vesicle Transport

Normal wtCFTR traffic / ER-to-Golgi

0.36

Delta508-CFTR traffic / ER-to-Golgi in CF

0.36

Membrane Trafficking

Membrane Trafficking

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for COPB2

Clathrin-dependent protein traffic

5 GeneGo (Thomson Reuters) Pathways for COPB2

	wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
	Delta508-CFTR traffic / ER-to-Golgi in CF
	Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF)
	Normal wtCFTR traffic / ER-to-Golgi
	Transport Clathrin-coated vesicle cycle

5/7 Reactome Pathways for COPB2 (see all 7)

	Hydrolysis of Arf1-GTP to Arf1-GDP
	Diffusion of inactive Arf1-GDP from membrane
	Membrane Trafficking
	COPI Mediated Transport
	Golgi to ER Retrograde Transport

COPB2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for COPB2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/857 Interacting proteins for COPB2 (P35606^{2, 3} ENSP00000329419⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 857)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
COPA	P53621²^,³, ENSP00000357048⁴	MINT-7945693 MINT-7947479 I2D: score=3 STRING: ENSP00000357048
ARCN1	P48444²^,³, ENSP00000264028⁴	MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000264028
COPB1	P53618²^,³, ENSP00000249923⁴	MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000249923
COPG1	Q9Y678²^,³, ENSP00000325002⁴	MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000325002
NELFCD	Q8IXH7²^,³, ENSP00000342300⁴	MINT-7945693 I2D: score=1 STRING: ENSP00000342300

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006886	intracellular protein transport	IEA	--
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	TAS	--
GO:0006891	intra-Golgi vesicle-mediated transport	IDA	8335000
GO:0016044	cellular membrane organization	TAS	--
GO:0016192	vesicle-mediated transport	--	--

COPB2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

COPB2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for COPB2

1 HMDB Compound for COPB2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

1 Novoseek chemical compound relationship for COPB2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
propargyl alcohol	97.4	20	8335000 (5), 1746915 (4), 10536883 (3), 10948998 (3) (see all 5)

Search CenterWatch for drugs/clinical trials and news about COPB2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for COPB2 gene:

NM_004766.2

Unigene Cluster for COPB2:

Coatomer protein complex, subunit beta 2 (beta prime)

Hs.681616 [show with all ESTs]

Unigene Representative Sequence: AK128561

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000503326 ENST00000333188(uc011bmv.2 uc003etf.4 uc010hui.3)

ENST00000507777 ENST00000502734 ENST00000512309 ENST00000510181(uc011bmw.1)

ENST00000515006 ENST00000512153 ENST00000513274 ENST00000512242 ENST00000510491

ENST00000514508 ENST00000504295(uc003etg.3)

miRNA Products:		OriGene 3'-UTR Clone: COPB2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COPB2
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate COPB2:
		hsa-miR-3163 hsa-miR-548c-3p
		SwitchGear 3'UTR luciferase reporter plasmid: COPB2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COPB2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COPB2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: COPB2 (NM_004766)
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COPB2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COPB2

Additional cDNA sequence:

AK128561.1 AK302943.1 AK304219.1 BC000326.2 NR_023350.1 X70476.1

24/31 DOTS entries (see all 31):

DT.100673475 DT.318761 DT.120851151 DT.92460828 DT.95343979 DT.120851108 DT.101966258 DT.100673474

DT.120851069 DT.91808111 DT.95343982 DT.95117308 DT.95339273 DT.100673486 DT.100733020 DT.120851038

DT.120851043 DT.120851045 DT.120851056 DT.120851065 DT.120851076 DT.120851116 DT.121619596 DT.92460826

24/569 AceView cDNA sequences (see all 569):

Z46071 AI194088 T29191 BU738701 NM_004766 CD671857 AA948245 CK429787

AA813747 CB113907 BF447035 CB114574 BM716615 AA352218 BM786285 BQ438970

BE900223 CA866261 BE728880 AI752973 BU628785 BQ183647 BM711398 AI333222

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for COPB2 (see all 9) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^
SP1:							-		-		-				-																												-
SP2:									-		-				-
SP3:															-
SP4:																											-		-		-		-		-		-						-
SP5:

ExUns:	22	^	23a	·	23b	^	24a	·	24b
SP1:			-
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for COPB2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

COPB2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCTTTGATT

About this image

COPB2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Liver Lobule

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See COPB2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for COPB2

SOURCE GeneReport for Unigene cluster: Hs.681616

SABiosciences Custom PCR Arrays for COPB2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COPB2 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COPB2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COPB2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPB2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for COPB2 gene from 10/38 species (see all 38) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Copb2^{1 , 5}	coatomer protein complex, subunit beta 2 (beta prime)^{1, 5}	91.97(n)¹ 98.34(a)¹		9 (51.40 cM)⁵ 50797¹ NM_015827.2¹ NP_056642.1¹ 98563731⁵
chicken (Gallus gallus)	Aves	COPB2¹	coatomer protein complex, subunit beta 2 (beta prime)	82.82(n) 93.93(a)		424823 XM_422637.3 XP_422637.2
lizard (Anolis carolinensis)	Reptilia	COPB2⁶	--	92(a)	1 ↔ 1	3(27508165-27524849)
African clawed frog (Xenopus laevis)	Amphibia	wufc55e05-prov²	coatomer protein complex, subunit beta 2 (beta prime)	75.5(n)		BC041755.1
zebrafish (Danio rerio)	Actinopterygii	wufc55e05²	wufc55e05	79.31(n)		325105 CK141713.1
fruit fly (Drosophila melanogaster)	Insecta	&bgr;'Cop³ beta'Cop¹	ER to Golgi transport³ beta'-coatomer protein¹	70(a)³ 63.57(n)¹ 69.03(a)¹		34B9³ 45757¹ NM_080097.3¹ NP_524836.2¹
worm (Caenorhabditis elegans)	Secernentea	F38E11.5³ CELE_F38E11.5¹	beta'-coat protein like³ Protein F38E11.5¹	65(a) (best of 3)³ 63.46(n)¹ 66.59(a)¹		IV(9459917-9463487)³ 177779¹ NM_069270.4¹ NP_501671.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	SEC27(YGL137W)⁴ SEC27¹	Essential beta'-coat protein of the COPI coatomer, more⁴ Sec27p¹	54.55(n)¹ 48.38(a)¹		7(249869-252738)⁴ 852740^{1, 4} NP_011378.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G79990¹	coatomer subunit beta'-1	62.13(n) 62.09(a)		844339 NM_001161006.1 NP_001154478.1
rice (Oryza sativa)	Liliopsida	Os.46583²	Oryza sativa (japonica cultivar-group) cDNA clone0 more	73.11(n)		AK111584.1

ENSEMBL Gene Tree for COPB2 (if available)
TreeFam Gene Tree for COPB2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs80170556^1,2		--	136482364(+)	`TTATAC/GAAATA`	5	--	us2k¹		0	--	--	--	--
rs200640065^1,2	C	--	136482692(-)	`CCCCCA/CCAATC`	5	--	us2k¹		0	--	--	--	--
rs66864140^1,2	C	--	136482694(+)	`GGGGGG/-TGTCT`	5	--	us2k¹		1		NA	2
rs1609482^1,2	A,	--	136482797(+)	`TCCTAG/TTTCCA`	5	--	us2k¹		0	--	--	--	--
rs79106943^1,2	C,	--	136482907(+)	`GATTCT/CGTGCT`	5	--	us2k¹		2		WA	120
rs113568512^1,2	C,	--	136483935(+)	`TCAGAC/TTGACT`	5	--	us2k¹		1		NA	2
rs78321136^1,2		--	136484466(+)	`CTGAAG/ATCAGA`	5	--	nc-transcript-variantint¹		1		WA	118
rs1609483^1,2	C,F,A,	--	136484779(+)	`cgcctA/Gtaatc`	5	--	int¹		6		NA WA CSA	11
rs112943468^1,2		--	136485461(+)	`CTTAAG/AAAAAA`	5	--	int¹		1		CSA	2
rs202166969^1,2	C	--	136485497(+)	`CTTCCA/TTTTTT`	5	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for COPB2 (139074442 - 139108574 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for COPB2: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COPB2

DNA2.0 Custom Variant and Variant Library Synthesis for COPB2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

COPB2 for disorders           About GeneDecksing

OMIM gene information: 606990    OMIM disorders: --

10 diseases for COPB2:    About MalaCards

retinol binding protein synovitis scleroderma sarcoma

lung cancer prostate cancer cholesterol prostatitis

malaria alcoholism

1 disease from the University of Copenhagen DISEASES database for COPB2:

Blepharophimosis

1 Novoseek disease relationship for COPB2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
sarcoma	41.7	3	1746915 (2), 8702231 (1)

Human Genome Epidemiology (HuGE) Navigator: COPB2 (1 document)

Export disorders for COPB2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for COPB2 gene, integrated from 9 sources (see all 56):
(articles sorted by number of sources associating them with COPB2)

Utopia: connect your pdf to the dynamic
world of online information

A 102 kDa subunit of a Golgi-associated particle has homology to beta subunits of trimeric G proteins. (PubMed id 8335000)^{1, 2, 9} Harrison-Lavoie K.J.... Willison K.R. (1993)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{1, 2} Gevaert K.... Vandekerckhove J. (2003)
Assignment of the cellular retinol-binding protein 1 gene (RBP1) and of the coatomer beta subunit gene (COPB2) to human chromosome band 3q23 by in situ hybridization. (PubMed id 9858824)^{1, 3} De Baere E....Messiaen L. (1998)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Protein interaction profiling of the p97 adaptor UBXD1 points to a role for the complex in modulating ERGIC-53 trafficking. (PubMed id 22337587)¹ Haines D.S....Deshaies R.J. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
Two new susceptibility loci for Kawasaki disease ident ified through genome-wide association analysis. (PubMed id 22446961)¹ Lee Y.C....Wu J.Y. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 9276	HGNC: 2232	AceView: COPB2	Ensembl:ENSG00000184432	euGenes: HUgn9276
ECgene: COPB2	H-InvDB: COPB2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for COPB2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for COPB2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for COPB2 gene:
Search GeneIP for patents involving COPB2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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coatomer protein complex, subunit beta 2 (beta prime)

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coatomer protein complex, subunit beta 2 (beta prime)

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