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COPB2 Gene

protein-coding   GIFtS: 61
GCID: GC03M139076

Coatomer Protein Complex, Subunit Beta 2 (Beta Prime)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Coatomer Protein Complex, Subunit Beta 2 (Beta Prime)1 2     betaprime-COP2
Beta'-Coat Protein2 3     Coatomer Binding Complex, Beta Prime Subunit2
p1022 3     Coatomer Subunit Beta'2
beta'-COP2     Beta'-COP3

External Ids:    HGNC: 22321   Entrez Gene: 92762   Ensembl: ENSG000001844327   OMIM: 6069905   UniProtKB: P356063   

Export aliases for COPB2 gene to outside databases

Previous GC identifers: GC03U990100 GC03M140357 GC03M140397 GC03M140559 GC03M136451


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for COPB2 Gene:
The Golgi coatomer complex (see MIM 601924) constitutes the coat of nonclathrin-coated vesicles and is essential
for Golgi budding and vesicular trafficking. It consists of 7 protein subunits, including COPB2.(supplied by
OMIM, Jul 2002)

GeneCards Summary for COPB2 Gene:
COPB2 (coatomer protein complex, subunit beta 2 (beta prime)) is a protein-coding gene. Diseases associated with COPB2 include blepharophimosis, and kawasaki disease. GO annotations related to this gene include structural molecule activity.

UniProtKB/Swiss-Prot: COPB2_HUMAN, P35606
Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with
Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the
Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is
essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only
be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins;
the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic
recycling of LDL receptors (By similarity)
Function: This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective
binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner
(By similarity)

Gene Wiki entry for COPB2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the COPB2 gene promoter:
         c-Fos   p53   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOPB2 promoter sequence
   Search Chromatin IP Primers for COPB2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COPB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q23   Ensembl cytogenetic band:  3q23   HGNC cytogenetic band: 3q23

COPB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COPB2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M139076:  view genomic region     (about GC identifiers)

Start:
139,074,442 bp from pter      End:
139,108,574 bp from pter
Size:
34,133 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: COPB2_HUMAN, P35606 (See protein sequence)
Recommended Name: Coatomer subunit beta'  
Size: 906 amino acids; 102487 Da
Subunit: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta
subunits. Probably interacts with PEX11A. Interacts with SCYL1 (By similarity)

Explore the universe of human proteins at neXtProt for COPB2: NX_P35606

Explore proteomics data for COPB2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys168, Lys318, Lys328, Lys346, Lys386, Lys608, Lys724, Lys771
  • Modification sites at PhosphoSitePlus

  • See COPB2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004757.1  
    ENSEMBL proteins: 
     ENSP00000426682   ENSP00000329419   ENSP00000422295   ENSP00000422917   ENSP00000423271  
     ENSP00000422547   ENSP00000424144   ENSP00000427185   ENSP00000422469  
    Reactome Protein details: P35606

    COPB2 Human Recombinant Protein Products:

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    Novus Biologicals COPB2 Proteins
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    Selected InterPro protein domains (see all 6):
     IPR006692 Coatomer_WD-assoc_reg
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR016453 COPB2
     IPR017986 WD40_repeat_dom

    Graphical View of Domain Structure for InterPro Entry P35606

    ProtoNet protein and cluster: P35606

    2 Blocks protein domains:
    IPB001680 G-protein beta WD-40 repeat signature
    IPB006692 Coatomer WD associated region


    UniProtKB/Swiss-Prot: COPB2_HUMAN, P35606
    Similarity: Belongs to the WD repeat COPB2 family
    Similarity: Contains 9 WD repeats


    COPB2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COPB2_HUMAN, P35606
    Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with
    Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the
    Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is
    essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only
    be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins;
    the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic
    recycling of LDL receptors (By similarity)
    Function: This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective
    binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner
    (By similarity)

         Genatlas biochemistry entry for COPB2:
    Golgi coatomer complex,beta subunit,component of the coat of non clathrin coated vesicles,putatively involved in
    regulating membrane trafficking in the exocytic pathway

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0005515protein binding ----
         
    COPB2 for ontologies           About GeneDecksing


    Phenotypes:
         15 GenomeRNAi human phenotypes for COPB2:
     Decreased Hepatitis C virus re  Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica  
     Decreased Salmonella-containin  Decreased Wnt reporter activit  Decreased cell number, increas  Decreased influenza A H1N1 (A/ 
     Decreased influenza A H1N1 (A/  Decreased influenza A virus in  Decreased influenza A/WSN/33 r  Decreased viability 
     Decreased viability of wild-ty  G0/1 arrest  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for COPB2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for COPB2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for COPB2

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    hsa-mir-877-3p (MIRT036883)

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    2 qRT-PCR Assays for microRNAs that regulate COPB2:
    hsa-miR-3163 hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidCOPB2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    COPB2_HUMAN, P35606: Cytoplasm, cytosol (By similarity). Golgi apparatus membrane; Peripheral membrane protein;
    Cytoplasmic side (By similarity). Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein;
    Cytoplasmic side (By similarity). Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the
    Golgi, as well as on the vesicles/buds originating from it (By similarity). Shows only a slight preference for
    the cis-Golgi apparatus, compared with the trans-Golgi (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    cytoskeleton4
    cytosol4
    nucleus2
    endoplasmic reticulum1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005794Golgi apparatus ----
    GO:0005829cytosol TAS--
    GO:0015629actin cytoskeleton ----
    GO:0030117membrane coat ----

    COPB2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for COPB2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Clathrin dependent protein traffic
    Clathrin dependent protein traffic0.66
    wtCFTR and delta508 CFTR traffic Generic schema norm and CF 0.37
    Transport Clathrin coated vesicle cycle0.66
    2COPI Mediated Transport
    COPI Mediated Transport0.31
    Golgi to ER Retrograde Transport0.00
    Cholesterol and Sphingolipids transport Transport from Golgi and ER to the apical membrane normal and CF 0.31
    3ER to Golgi Transport
    Delta508 CFTR traffic ER to Golgi in CF0.36
    Normal wtCFTR traffic ER to Golgi 0.36
    4Clathrin derived vesicle budding
    Membrane Trafficking0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5 GeneGo (Thomson Reuters) Pathways for COPB2
        wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
    Delta508-CFTR traffic / ER-to-Golgi in CF
    Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF)
    Normal wtCFTR traffic / ER-to-Golgi
    Transport Clathrin-coated vesicle cycle

    1 Reactome Pathway for COPB2
        COPI Mediated Transport



    COPB2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for COPB2
    Interactions:

        GeneGlobe Interaction Network for COPB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for COPB2 (P356062, 3 ENSP000003294194) via UniProtKB, MINT, STRING, and/or I2D (see all 938)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COPAP536212, 3, ENSP000003570484MINT-7945693 MINT-7947479 I2D: score=3 STRING: ENSP00000357048
    ARCN1P484442, 3, ENSP000002640284MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000264028
    COPB1P536182, 3, ENSP000002499234MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000249923
    COPG1Q9Y6782, 3, ENSP000003250024MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000325002
    NELFCDQ8IXH72, 3, ENSP000003423004MINT-7945693 I2D: score=1 STRING: ENSP00000342300
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0006890retrograde vesicle-mediated transport, Golgi to ER TAS11030615
    GO:0006891intra-Golgi vesicle-mediated transport IDA8335000
    GO:0016192vesicle-mediated transport ----
    GO:0048205COPI coating of Golgi vesicle TAS--

    COPB2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for COPB2

    1 HMDB Compound for COPB2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    1 Novoseek inferred chemical compound relationship for COPB2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    propargyl alcohol 97.4 20 8335000 (5), 1746915 (4), 10536883 (3), 10948998 (3) (see all 5)



    COPB2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for COPB2 gene: 
    NM_004766.2  

    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000503326 ENST00000333188(uc011bmv.2 uc003etf.4 uc010hui.3)
    ENST00000507777 ENST00000502734 ENST00000512309 ENST00000510181(uc011bmw.1)
    ENST00000515006 ENST00000512153 ENST00000513274 ENST00000512242 ENST00000510491
    ENST00000514508 ENST00000504295(uc003etg.3)
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    hsa-miR-3163 hsa-miR-548c-3p
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      QuantiFast Probe-based Assays in human, mouse, rat COPB2

    Selected AceView cDNA sequences (see all 569):

    BM849710 CB154231 AI658694 AL135044 BG697691 W52282 BM310959 BQ438970 
    BE728005 BQ014788 CA389380 AW166800 BU173423 BM723596 CA418438 CN480861 
    BE266337 BM719874 AI361137 BC000326 AW299963 AI333222 BM711398 CA429978 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for COPB2 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
    SP1:                    -     -     -           -                                                                                   -                           
    SP2:                          -     -           -                                                                                                               
    SP3:                                            -                                                                                                               
    SP4:                                                                                -     -     -     -     -     -                 -                           
    SP5:                                                                                                                                                            

    ExUns: 22 ^ 23a · 23b ^ 24a · 24b
    SP1:        -                     
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for COPB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    COPB2 expression in normal human tissues (normalized intensities)      COPB2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCTTTGATT
    COPB2 Expression
    About this image


    COPB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Testis (Reproductive System)
     
     Fibroblasts (Uncategorized)
    COPB2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    COPB2 Protein Expression
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPB2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for COPB2 gene from Selected species (see all 28)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Copb21 , 5 coatomer protein complex, subunit beta 2 (beta prime)1, 5 91.97(n)1
    98.34(a)1
      9 (51.40 cM)5
    507971  NM_015827.21  NP_056642.11 
     985637315 
    chicken
    (Gallus gallus)
    Aves COPB21 coatomer protein complex, subunit beta 2 (beta prime) 82.82(n)
    93.93(a)
      424823  XM_422637.4  XP_422637.2 
    lizard
    (Anolis carolinensis)
    Reptilia COPB26
    coatomer protein complex, subunit beta 2 (beta pri...
    92(a)
    1 ↔ 1
    3(27506757-27524849)
    African clawed frog
    (Xenopus laevis)
    Amphibia wufc55e05-prov2 coatomer protein complex, subunit beta 2 (beta prime) 75.5(n)    BC041755.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc55e052 wufc55e05 79.31(n)   325105  CK141713.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta &bgr;'Cop3
    beta'Cop1
    ER to Golgi transport3
    beta'-coatomer protein1
    70(a)3
    64.12(n)1
    69.21(a)1
      34B93
    457571  NM_080097.31  NP_524836.21 
    worm
    (Caenorhabditis elegans)
    Secernentea F38E11.53
    CELE_F38E11.51
    beta'-coat protein like3
    CELE_F38E11.51
    65(a)
    (best of 3)3
    63.42(n)1
    66.59(a)1
      IV(9459917-9463487)3
    1777791  NM_069270.51  NP_501671.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SEC27(YGL137W)4
    SEC271
    Essential beta'-coat protein of the COPI coatomer, more4
    SEC271
    54.24(n)1
    48.13(a)1
      7(249869-252738)4
    8527401, 4  NP_011378.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G799901 AT1G79990 62.13(n)
    62.09(a)
      844339  NM_001161006.1  NP_001154478.1 
    rice
    (Oryza sativa)
    Liliopsida Os.465832 Oryza sativa (japonica cultivar-group) cDNA clone0 more 73.11(n)    AK111584.1 


    ENSEMBL Gene Tree for COPB2 (if available)
    TreeFam Gene Tree for COPB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for COPB2 gene
    5 SIMAP similar genes for COPB2 using alignment to 9 protein entries:     COPB2_HUMAN (see all proteins):
    PF20    POC1B    STRN4    WDR61    KATNB1

    COPB2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for COPB2 (see all 644)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1881942641,2
    --139076424(+) AACAAC/GTACCT 2 -- int10--------
    rs1510539811,2
    --139076509(+) AACAAA/GGAAAA 2 -- ut31 nc-transcript-variant0--------
    rs1998884551,2
    C--139076686(+) TCAGGA/TAAATG 2 -- ut31 nc-transcript-variant0--------
    rs1437083261,2
    C--139076713(+) ATCATC/TCAAAA 3 N D mis11Minor allele frequency- T:0.00NA 4356
    rs2009773161,2
    C--139076804(+) CTCTGC/GAGACA 2 -- int10--------
    rs23070311,2
    C,F,H--139076820(+) AAGAGG/TGTAAT 2 -- int1 trp316Minor allele frequency- T:0.05EA NS WA NA 3814
    rs2004204461,2
    --139076828(+) AATTAA/GGTTTT 2 -- int10--------
    rs1409814971,2
    --139076857(+) AGTTAC/TCCGTG 2 -- int10--------
    rs1161661631,2
    F--139076899(+) TCTTAA/CTAGTC 2 -- int11Minor allele frequency- C:0.01WA 118
    rs1927811651,2
    --139076973(+) GCCTAC/TGTATC 2 -- int10--------

    HapMap Linkage Disequilibrium report for COPB2 (139074442 - 139108574 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for COPB2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv4034CNV Loss18451855
    nsv877543CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing COPB2
    DNA2.0 Custom Variant and Variant Library Synthesis for COPB2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606990    OMIM disorders: --

    8 diseases for COPB2:    About MalaCards
    blepharophimosis    kawasaki disease    synovitis    scleroderma
    sarcoma    prostate cancer    prostatitis    malaria

    1 disease from the University of Copenhagen DISEASES database for COPB2:
    Blepharophimosis

    COPB2 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for COPB2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sarcoma 41.7 3 1746915 (2), 8702231 (1)

    Human Genome Epidemiology (HuGE) Navigator: COPB2 (1 document)

    Export disorders for COPB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for COPB2 gene, integrated from 10 sources (see all 62):
    (articles sorted by number of sources associating them with COPB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A 102 kDa subunit of a Golgi-associated particle has homology to beta subunits of trimeric G proteins. (PubMed id 8335000)1, 2, 9 Harrison-Lavoie K.J.... Willison K.R. (EMBO J. 1993)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    5. Assignment of the cellular retinol-binding protein 1 gene (RBP1) and of the coatomer beta subunit gene (COPB2) to human chromosome band 3q23 by in situ hybridization. (PubMed id 9858824)1, 3 De Baere E....Messiaen L. (Cytogenet. Cell Genet. 1998)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. Protein interaction profiling of the p97 adaptor UBXD1 points to a role for the complex in modulating ERGIC-53 trafficking. (PubMed id 22337587)1 Haines D.S....Deshaies R.J. (amp 2012)
    10. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 9276 HGNC: 2232 AceView: COPB2 Ensembl:ENSG00000184432 euGenes: HUgn9276
    ECgene: COPB2 H-InvDB: COPB2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for COPB2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for COPB2 gene:
    Search GeneIP for patents involving COPB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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