COPB1 Gene
protein-coding GIFtS : 60 GCID: GC11 M014436
coatomer protein complex, subunit beta 1 coatomer protein complex, subunit beta )COPB )
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Aliasesfor COPB1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Coatomer Protein Complex, Subunit Beta 1 1 2 Beta Coat Protein2 COPB1 2 3 5 Beta-Cop1 Beta-Coat Protein2 3 Coatomer Subunit Beta2 Coatomer Protein Complex, Subunit Beta1 Beta-COP3
Export aliases for COPB1 gene to outside databases Previous GC identifer: GC11M014160
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Summariesfor COPB1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for COPB1 : This gene encodes a protein subunit of the coatomer complex associated with non-clathrin coated vesicles. The coatomer complex, also known as the coat protein complex 1, forms in the cytoplasm and is recruited to the Golgi by activated guanosine triphosphatases. Once at the Golgi membrane, the coatomer complex may assist in the movement of protein and lipid components back to the endoplasmic reticulum. Alternatively spliced transcript variants have been described. (provided by RefSeq, Jan 2009) UniProtKB/Swiss-Prot: COPB_HUMAN, P53618 Function : The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates withGolgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Plays a functional role in facilitating the transport of kappa-type opioid receptor mRNAs into axons and enhances translation of these proteins. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte surface triglyceride lipase (PNPLA2) with the lipid droplet to mediate lipolysis (By similarity). Involved in the Golgi disassembly and reassembly processes during cell cycle. Involved in autophagy by playing a role in early endosome function. Plays a role in organellar compartmentalization of secretory compartments including endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC), Golgi, trans-Golgi network (TGN) and recycling endosomes, and in biosynthetic transport of CAV1. Promotes degradation of Nef cellular targets CD4 and MHC class I antigens by facilitating their trafficking to degradative compartments Gene Wiki entry for COPB1
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Genomic Viewsfor COPB1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000011.9 NC_018922.1 NT_009237.18 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the COPB1 gene promoter:p53 Lmo2 Msx-1 Gfi-1 Other transcription factors Search SABiosciences Chromatin IP Primers for COPB1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 11p15.2 Ensembl cytogenetic band: 11p15.2 HGNC cytogenetic band: 11p15.2 COPB1 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11M014436: view genomic region
(about GC identifiers )
Start: 14,464,986 bp from pter End:
14,521,573 bp from pter
Size: 56,588 bases Orientation:
minus strand
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Proteinsfor COPB1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: COPB_HUMAN, P53618 See
protein sequence )Recommended Name: Size : 953 amino acids; 107142 DaSubunit : Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.Interacts (via C-terminus) with HIV-1 Nef; the interaction is direct. Interacts with SCYL1. Interacts with COPG1. Interacts (via trunk domain) with ARF1 (via switch I region); the interaction is direct. Interacts with KCNK2/TREK (via N-terminus); this interaction increases the channel-mediated whole cell currents and promotes plasma membrane expression of KCNK2/TREK. Interacts with anthrax lethal factor (LF); this interaction may facilitate endosomal vesicle membrane translocation of LF and its release from the lumen of endosomal vesicles to external milieu. Interacts with CAPN8 and PRKCE (By similarity). Interacts with ARF1 (myristoylated); this interaction is required for binding of COPB1 to Golgi membranes (By similarity)
Subcellular location : Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmicvesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane. Endoplasmic reticulum-Golgi intermediate compartment. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Proteolytic cleavage by CAPN8 triggers translocation from Golgi to cytoplasm (By similarity). Found in perinuclear vesicular-tubular clusters (VTCs) and in the Golgi region where associated with vesicles, buds and rims of the Golgi stack (By similarity). Occasionally present at the trans-side of Golgi, but mainly present at the cis-Golgi side in transitional areas (TA), on so-called peripheral elements (PE) consisting of tubules and vesicles located between the cup-shaped transitional elements (TE) of the rough endoplasmic reticulum (RER) and the cis-most Golgi cisternae (By similarity). Present in cytoplasm, not associated with visible coats or membranes, with a minor fraction present on small clusters of tubules and vesicles (By similarity). Some association with high-density and low-density microsomes and mitochondria/nuclei fraction (By similarity). Very little found in plasma membrane fraction (By similarity)
Miscellaneous : Brefeldin A induces dissociation from the Golgi of the beta-COP and presumably the other coatomersubunits
Secondary accessions : D3DQX0 Q6GTT7 Q9NTK2 Q9UNW7Explore the universe of human proteins at neXtProt for COPB1: NX_P53618 Post-translational modifications:
Proteolytically cleaved between Ser-528 and Ser-529 by CAPN8 (By similarity)1 View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P53618 COPB1 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (3 alternative transcripts): NP_001137533.1 NP_001137534.1 NP_057535.1 ENSEMBL proteins: ENSP00000249923 ENSP00000397873 ENSP00000436383 ENSP00000431530 ENSP00000436401 Reactome Protein details: P53618 Human Recombinant Protein Products: Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9 ): About this table
About GeneDecksing COPB1 Antibody Products: Assay Products for COPB1:
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Protein
Domains /for COPB1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 5 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P53618 ProtoNet protein and cluster: P53618
2 Blocks protein families : IPB002553 IPB011710 UniProtKB/Swiss-Prot: COPB_HUMAN, P53618 Similarity : Contains 6 HEAT repeats
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Functionfor COPB1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: COPB_HUMAN, P53618 Function : The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates withGolgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Plays a functional role in facilitating the transport of kappa-type opioid receptor mRNAs into axons and enhances translation of these proteins. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte surface triglyceride lipase (PNPLA2) with the lipid droplet to mediate lipolysis (By similarity). Involved in the Golgi disassembly and reassembly processes during cell cycle. Involved in autophagy by playing a role in early endosome function. Plays a role in organellar compartmentalization of secretory compartments including endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC), Golgi, trans-Golgi network (TGN) and recycling endosomes, and in biosynthetic transport of CAV1. Promotes degradation of Nef cellular targets CD4 and MHC class I antigens by facilitating their trafficking to degradative compartments
Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 5 )human mouse rat see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): COPB1 (NM_016451 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COPB1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat COPB1
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPB1
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
About GeneDecksing 12 GenomeRNAi human phenotypes for COPB1 :
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Pathways & Interactionsfor COPB1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways About this table See pathways by source Super-pathway contained gene-specific pathways 1 Coatomer:Arf1-GTP:GAP lattice formation on golgi membrane 2 Clathrin-dependent protein traffic 3 COPII (Coat Protein 2) Mediated Vesicle Transport 4 Membrane Trafficking
Pathway sources See GeneCards unified pathways Show all pathways 1 5 5/7 (see all 7 )About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for COPB1 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/901 Interacting proteins for COPB1 (P53618 2 , 3 ENSP00000249923 4 via UniProtKB, MINT, STRING , and/or I2D (see all 901 )Interactant Interaction Details GeneCard External ID(s) COPA P53621 2 , 3 ENSP00000357048 4 MINT-7945693 MINT-8217717 MINT-7947479 I2D:
score=7 STRING: ENSP00000357048 COPG1 Q9Y678 2 , 3 ENSP00000325002 4 MINT-7945693 MINT-8217717 MINT-7947479 I2D:
score=2 STRING: ENSP00000325002 ARCN1 P48444 2 , 3 ENSP00000264028 4 MINT-7945693 MINT-8217717 MINT-7947479 I2D:
score=12 STRING: ENSP00000264028 COPB2 P35606 2 , 3 ENSP00000329419 4 MINT-7945693 MINT-7947479 I2D:
score=1 STRING: ENSP00000329419 SUN2 Q9UH99 2 , 3 ENSP00000216064 4 MINT-7993501 MINT-7993475 I2D:
score=1 STRING: ENSP00000216064
About this table Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006886 intracellular protein transport
IEA -- GO:0006890 retrograde vesicle-mediated transport, Golgi to ER
TAS -- GO:0006891 intra-Golgi vesicle-mediated transport
ISS -- GO:0016044 cellular membrane organization
TAS -- GO:0016192 vesicle-mediated transport
-- --
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Drugs & Compoundsfor COPB1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for COPB1 1 HMDB Compound for COPB1 About this table 3 Novoseek chemical compound relationships for COPB1 gene About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
guanosine 5'-o-(3-thiotriphosphate)
50.8
1
1957170 (1)
gtp
20.4
3
1957170 (1)
caffeine
20.3
3
9352220 (1), 8449979 (1)
COPB1 / COPB
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Transcriptsfor COPB1 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for COPB1 gene (3 alternative transcripts): NM_001144061.1 NM_001144062.1 NM_016451.4 Unigene Cluster for COPB1:
Coatomer protein complex, subunit beta 1 Hs.339278 [show with all ESTs ] Unigene Representative Sequence: BC037280 12 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000532088 ENST00000525214 ENST00000249923 (uc001mli.2 uc001mlg.2 uc001mlh.2 )ENST00000439561 ENST00000526527 ENST00000526191 ENST00000534234 ENST00000529866 ENST00000534771 ENST00000533096 ENST00000533533 ENST00000529210 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 5 )human mouse rat see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): COPB1 (NM_016451 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COPB1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat COPB1
Additional cDNA sequence: AF084457.1 AF111807.1 AK001203.1 AK021446.1 AL136593.1 BC012572.1 BC037280.2 X82103.1
24/29 DOTS entries (see all 29 ): DT.95235278 DT.100822940
DT.95108192 DT.101960558 DT.451536 DT.100663573 DT.95235280 DT.100822945 DT.86852836 DT.120705217 DT.97809974 DT.120705264 DT.70102283 DT.100767855 DT.100822943 DT.120705259 DT.120705261 DT.95235276 DT.95235281 DT.100730165 DT.100822939 DT.102832733 DT.120705250 DT.120705256 24/506 AceView cDNA sequences (see all 506 ):
CA426979 AW515386 T31822 CA424550 CA414248 BM785334 BQ929381 AU128830 AW468574 BI793018 BU190069 BQ436344 AI129763 BU195107 BF970532 BG120345 AA453485 AA344611 AA412084 CB118545 BM541482 CR605573 AA029336 AA328775 GeneLoc Exon Structure 5/15 Alternative Splicing Database (ASD) splice patterns (SP) for COPB1 (see all 15 ) About this scheme ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ SP1 : - - - SP2 : - - - - - - SP3 : - - - - - SP4 : - - - - - SP5 : - - -
ExUns: 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25a · 25b SP1 : - - SP2 : - - SP3 : - - SP4 : SP5 :
ECgene alternative splicing isoforms for COPB1
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Expression for COPB1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section COPB1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TACCAAGACC
About this image COPB1 expression in embryonic tissues and stem cells About this table See COPB1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for COPB1 SOURCE GeneReport for Unigene cluster: Hs.339278 SABiosciences Custom PCR Arrays for COPB1 Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPB1
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Orthologsfor COPB1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for COPB1 gene from 10/41 species (see all 41 ) About this table
ENSEMBL Gene Tree for COPB1 (if available)TreeFam Gene Tree for COPB1 (if available)
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Paralogsfor COPB1 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section
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Genomic Variantsfor COPB1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 11 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for COPB1 (14464986 - 14521573 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for COPB1 1 CNV 6908
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor COPB1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 600959
OMIM disorders : --14 : About MalaCards otitis media oculocerebrorenal syndrome menkes disease herpes simplex wilson disease glanders neurodegeneration ischemia ataxia cholesterol immunodeficiency hepatitis malaria vesiculitis 3 diseases from the University of Copenhagen DISEASES database for COPB1 :Menkes disease Wilson disease Otitis media Export disorders for COPB1 gene to outside databases
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Publicationsfor COPB1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for COPB1 gene, integrated from 9 sources (see all 110 ):(articles sorted by number of sources associating them with COPB1) Utopia : connect your pdf to the dynamic
Physical interaction of the HIV-1 Nef protein with beta-COP, a component of non-clathrin-coated vesicles essential for membrane traffic. (PubMed id 7982906) 1 , 2 , 3(1994) HIV-1 Nef targets MHC-I and CD4 for degradation via a final common beta-COP-dependent pathway in T cells. (PubMed id 18725938) 1 , 2 , 9(2008) Scyl1, mutated in a recessive form of spinocerebellar neurodegeneration, regulates COPI-mediated retrograde traffic. (PubMed id 18556652) 1 , 2 (2008) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 (2004) Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166) 1 , 2 (2001) Identification and characterization of novel isoforms of COP I subunits. (PubMed id 11056392) 1 , 2 (2000) Screen and identification of proteins interacting with ADAM19 cytoplasmic tail. (PubMed id 12463424) 1 , 9(2002) The oculocerebrorenal syndrome gene product is a 105-kD protein localized to the Golgi complex. (PubMed id 7573041) 2 , 9(1995) A census of human soluble protein complexes. (PubMed id 22939629) 1 (2012) Protein interaction profiling of the p97 adaptor UBXD1 points to a role for the complex in modulating ERGIC-53 trafficking. (PubMed id 22337587) 1 (2012)
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Genome Databases showing COPB1 gene
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Specialized Databases showing COPB1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for COPB1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for COPB1 gene: COPB1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor COPB1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for COPB1 OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for COPB1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for COPB1 OriGene 3'-UTR Clone for COPB1 OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for COPB1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for COPB1 OriGene Custom Protein Services for COPB1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat COPB1 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Search Tocris compounds for COPB1
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPB1
ThermoFisher Antibody for COPB1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat COPB1
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Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Anatomical Compartment 
Negative
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Microarrays
