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Aliases for COPA Gene

Aliases for COPA Gene

  • Coatomer Protein Complex Subunit Alpha 2 3 5
  • Coatomer Protein Complex, Subunit Alpha 2 3
  • Alpha-Coat Protein 3 4
  • Alpha-COP 3 4
  • Proxenin 2 3
  • HEP-COP 3 4
  • HEPCOP 3 4
  • Xenin 2 3
  • Alpha Coat Protein 3
  • AILJK 3

External Ids for COPA Gene

Previous GeneCards Identifiers for COPA Gene

  • GC01M158051
  • GC01M155991
  • GC01M157036
  • GC01M157475
  • GC01M157072
  • GC01M158525
  • GC01M131615

Summaries for COPA Gene

Entrez Gene Summary for COPA Gene

  • In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1P, the alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone. Alternative splicing results in multiple splice forms encoding distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for COPA Gene

COPA (Coatomer Protein Complex Subunit Alpha) is a Protein Coding gene. Diseases associated with COPA include autoimmune interstitial lung, joint, and kidney disease and autoimmune interstitial lung disease-arthritis syndrome. Among its related pathways are Transport to the Golgi and subsequent modification and Golgi-to-ER retrograde transport. GO annotations related to this gene include structural molecule activity and hormone activity.

UniProtKB/Swiss-Prot for COPA Gene

  • The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).

  • Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor.

Gene Wiki entry for COPA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COPA Gene

Genomics for COPA Gene

Regulatory Elements for COPA Gene

Enhancers for COPA Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around COPA on UCSC Golden Path with GeneCards custom track

Promoters for COPA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around COPA on UCSC Golden Path with GeneCards custom track

Genomic Location for COPA Gene

Chromosome:
1
Start:
160,288,587 bp from pter
End:
160,343,564 bp from pter
Size:
54,978 bases
Orientation:
Minus strand

Genomic View for COPA Gene

Genes around COPA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COPA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COPA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COPA Gene

Proteins for COPA Gene

  • Protein details for COPA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53621-COPA_HUMAN
    Recommended name:
    Coatomer subunit alpha
    Protein Accession:
    P53621
    Secondary Accessions:
    • Q5T201
    • Q8IXZ9

    Protein attributes for COPA Gene

    Size:
    1224 amino acids
    Molecular mass:
    138346 Da
    Quaternary structure:
    • Oligomeric complex that consists of at least the alpha, beta, beta, gamma, delta, epsilon and zeta subunits. Probably interacts with PEX11A. Interacts with SCYL1 (By similarity). Interacts with JAGN1.

    Alternative splice isoforms for COPA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COPA Gene

Proteomics data for COPA Gene at MOPED

Post-translational modifications for COPA Gene

  • Ubiquitination at Lys 61, Lys 81, Lys 238, Lys 337, Lys 350, Lys 362, Lys 411, Lys 441, Lys 447, Lys 480, Lys 598, Lys 600, Lys 727, Lys 825, and Lys 1028
  • Modification sites at PhosphoSitePlus

Other Protein References for COPA Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for COPA Gene

Domains & Families for COPA Gene

Suggested Antigen Peptide Sequences for COPA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P53621

UniProtKB/Swiss-Prot:

COPA_HUMAN :
  • Contains 7 WD repeats.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with COPA: view

Function for COPA Gene

Molecular function for COPA Gene

GENATLAS Biochemistry:
Golgi coatomer complex alpha subunit,component of the coat of the non-clathrin-coated vesicles,expressed in a wide range of fetal and adult tissues,homolog to the alpha subunit of S cerevisiae coatomer protein complex,involved in the transport between the endoplasmic reticulum and Golgi
UniProtKB/Swiss-Prot Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).
UniProtKB/Swiss-Prot Function:
Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor.
genes like me logo Genes that share phenotypes with COPA: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COPA Gene

Localization for COPA Gene

Subcellular locations from UniProtKB/Swiss-Prot for COPA Gene

Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. {ECO:0000250}.
Xenin: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COPA Gene COMPARTMENTS Subcellular localization image for COPA gene
Compartment Confidence
cytosol 5
extracellular 5
golgi apparatus 5
nucleus 3
cytoskeleton 2
endoplasmic reticulum 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for COPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with COPA: view

Pathways & Interactions for COPA Gene

genes like me logo Genes that share pathways with COPA: view

Gene Ontology (GO) - Biological Process for COPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS --
GO:0048205 COPI coating of Golgi vesicle TAS --
genes like me logo Genes that share ontologies with COPA: view

No data available for SIGNOR curated interactions for COPA Gene

Drugs & Compounds for COPA Gene

(3) Drugs for COPA Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with COPA: view

Transcripts for COPA Gene

Alternative Splicing Database (ASD) splice patterns (SP) for COPA Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c ^
SP1: -
SP2:
SP3: -
SP4:
SP5: -
SP6: -
SP7: - - - -
SP8:
SP9: -
SP10:
SP11:
SP12: -

ExUns: 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for COPA Gene

GeneLoc Exon Structure for
COPA
ECgene alternative splicing isoforms for
COPA

Expression for COPA Gene

mRNA expression in normal human tissues for COPA Gene

Protein differential expression in normal tissues from HIPED for COPA Gene

This gene is overexpressed in Breast (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for COPA Gene



SOURCE GeneReport for Unigene cluster for COPA Gene Hs.162121

mRNA Expression by UniProt/SwissProt for COPA Gene

P53621-COPA_HUMAN
Tissue specificity: Uniformly expressed in a wide range of adult and fetal tissues. Xenin is found in gastric, duodenal and jejunal mucosa. Circulates in the blood. Seems to be confined to specific endocrine cells.
genes like me logo Genes that share expression patterns with COPA: view

Protein tissue co-expression partners for COPA Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for COPA Gene

Orthologs for COPA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for COPA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia COPA 35
  • 93.27 (n)
  • 99.02 (a)
COPA 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COPA 35
  • 91.93 (n)
  • 98.43 (a)
COPA 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Copa 35
  • 91.07 (n)
  • 98.45 (a)
Copa 16
Copa 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia COPA 35
  • 99.78 (n)
  • 99.84 (a)
COPA 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Copa 35
  • 91.23 (n)
  • 98.45 (a)
oppossum
(Monodelphis domestica)
Mammalia COPA 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COPA 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves COPA 35
  • 82.9 (n)
  • 96.57 (a)
COPA 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 80 (a)
OneToMany
-- 36
  • 97 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia copa 35
  • 80.83 (n)
  • 93.46 (a)
zebrafish
(Danio rerio)
Actinopterygii copa 35
  • 75.36 (n)
  • 86.75 (a)
copa 36
  • 87 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta alphaCop 37
  • 69 (a)
alphaCop 35
  • 66.01 (n)
  • 71.72 (a)
alphaCop 36
  • 71 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010251 35
  • 65.22 (n)
  • 72.03 (a)
worm
(Caenorhabditis elegans)
Secernentea Y71F9AL.17 37
  • 64 (a)
Y71F9AL.17 35
  • 60.18 (n)
  • 60.98 (a)
copa-1 36
  • 59 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR077C 35
  • 50.88 (n)
  • 46.42 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F04884g 35
  • 52.22 (n)
  • 46.71 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COP1 35
  • 51.7 (n)
  • 45.9 (a)
COP1 36
  • 45 (a)
OneToMany
COP1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G62020 35
  • 60.04 (n)
  • 57.23 (a)
rice
(Oryza sativa)
Liliopsida Os09g0127800 35
  • 59.47 (n)
  • 57.91 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU10066 35
  • 55.83 (n)
  • 51.85 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBPJ4664.04 35
  • 52.84 (n)
  • 48.99 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.184 36
  • 73 (a)
OneToOne
Species with no ortholog for COPA:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for COPA Gene

ENSEMBL:
Gene Tree for COPA (if available)
TreeFam:
Gene Tree for COPA (if available)

Paralogs for COPA Gene

No data available for Paralogs for COPA Gene

Variants for COPA Gene

Sequence variations from dbSNP and Humsavar for COPA Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_033803 -
VAR_066525 -
VAR_073844 Autoimmune interstitial lung, joint, and kidney disease (AILJK)
VAR_073845 Autoimmune interstitial lung, joint, and kidney disease (AILJK)
VAR_073846 Autoimmune interstitial lung, joint, and kidney disease (AILJK)

Structural Variations from Database of Genomic Variants (DGV) for COPA Gene

Variant ID Type Subtype PubMed ID
nsv3210 CNV Loss 18451855
esv272694 CNV Insertion 20981092

Variation tolerance for COPA Gene

Residual Variation Intolerance Score: 10.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.54; 64.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COPA Gene

HapMap Linkage Disequilibrium report
COPA
Human Gene Mutation Database (HGMD)
COPA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COPA Gene

Disorders for COPA Gene

MalaCards: The human disease database

(6) MalaCards diseases for COPA Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search COPA in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

COPA_HUMAN
  • Autoimmune interstitial lung, joint, and kidney disease (AILJK) [MIM:616414]: An autoimmune disease characterized by inflammatory arthritis, interstitial lung disease, and immune complex-mediated renal disease. {ECO:0000269 PubMed:25894502}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for COPA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COPA
genes like me logo Genes that share disorders with COPA: view

No data available for Genatlas for COPA Gene

Publications for COPA Gene

  1. HEP-COP, a novel human gene whose product is highly homologous to the alpha-subunit of the yeast coatomer protein complex. (PMID: 8647451) Chow V.T.K. … Quek H.H. (Gene 1996) 2 3 4 23 67
  2. Xenin -- a review. (PMID: 9533652) Feurle G.E. (Peptides 1998) 3 23
  3. Molecular and cellular studies of the human homolog of the 160-kD alpha-subunit of the coatomer protein complex. (PMID: 9115636) Quek H.H. … Chow V.T. (DNA Cell Biol. 1997) 3 23
  4. Genomic organization and mapping of the human HEP-COP gene (COPA) to 1q. (PMID: 9186507) Quek H.H. … Chow V.T. (Cytogenet. Cell Genet. 1997) 3 23
  5. Alpha coat protein COPA (HEP-COP): presence of an Alu repeat in cDNA and identity of the amino terminus to xenin. (PMID: 9365789) Chow V.T.K. … Quek H.H. (Ann. Hum. Genet. 1997) 3 23

Products for COPA Gene

Sources for COPA Gene

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