Free for academic non-profit institutions. Other users need a Commercial license

Aliases for COPA Gene

Aliases for COPA Gene

  • Coatomer Protein Complex, Subunit Alpha 2 3
  • Alpha-Coat Protein 3 4
  • Alpha-COP 3 4
  • Proxenin 2 3
  • HEP-COP 3 4
  • HEPCOP 3 4
  • Xenin 2 3
  • Coatomer Subunit Alpha 3
  • Alpha Coat Protein 3

External Ids for COPA Gene

Summaries for COPA Gene

Entrez Gene Summary for COPA Gene

  • In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1P, the alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone. Alternative splicing results in multiple splice forms encoding distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for COPA Gene

COPA (Coatomer Protein Complex, Subunit Alpha) is a Protein Coding gene. Among its related pathways are Arf1 pathway and COPI Mediated Transport. GO annotations related to this gene include structural molecule activity and hormone activity. An important paralog of this gene is STRN.

UniProtKB/Swiss-Prot for COPA Gene

  • The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).

  • Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor

Gene Wiki entry for COPA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COPA Gene

Genomics for COPA Gene

Genomic Location for COPA Gene

Start:
160,288,587 bp from pter
End:
160,343,564 bp from pter
Size:
54,978 bases
Orientation:
Minus strand

Genomic View for COPA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COPA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COPA Gene

Regulatory Elements for COPA Gene

Proteins for COPA Gene

  • Protein details for COPA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53621-COPA_HUMAN
    Recommended name:
    Coatomer subunit alpha
    Protein Accession:
    P53621
    Secondary Accessions:
    • Q5T201
    • Q8IXZ9

    Protein attributes for COPA Gene

    Size:
    1224 amino acids
    Molecular mass:
    138346 Da
    Quaternary structure:
    • Oligomeric complex that consists of at least the alpha, beta, beta, gamma, delta, epsilon and zeta subunits. Probably interacts with PEX11A. Interacts with SCYL1 (By similarity). Interacts with JAGN1.

    Alternative splice isoforms for COPA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COPA Gene

Proteomics data for COPA Gene at MOPED

Post-translational modifications for COPA Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys61, Lys81, Lys170, Lys238, Lys271, Lys337, Lys350, Lys362, Lys411, Lys441, Lys447, Lys480, Lys598, Lys600, Lys727, Lys825, and Lys1028

Other Protein References for COPA Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for COPA Gene

Domains for COPA Gene

Gene Families for COPA Gene

HGNC:
  • ENDOLIG :Endogenous ligands
  • WDR :WD repeat domain containing

UniProtKB/Swiss-Prot:

COPA_HUMAN
Similarity:
  • Contains 7 WD repeats.:
    • P53621
genes like me logo Genes that share domains with COPA: view

Function for COPA Gene

Molecular function for COPA Gene

GENATLAS Biochemistry: Golgi coatomer complex alpha subunit,component of the coat of the non-clathrin-coated vesicles,expressed in a wide range of fetal and adult tissues,homolog to the alpha subunit of S cerevisiae coatomer protein complex,involved in the transport between the endoplasmic reticulum and Golgi
UniProtKB/Swiss-Prot Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).
UniProtKB/Swiss-Prot Function: Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor

Gene Ontology (GO) - Molecular Function for COPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity IEA --
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with COPA: view
genes like me logo Genes that share phenotypes with COPA: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for COPA Gene

Localization for COPA Gene

Subcellular locations from UniProtKB/Swiss-Prot for COPA Gene

Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. {ECO:0000250}.
Xenin: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COPA Gene COMPARTMENTS Subcellular localization image for COPA gene
Compartment Confidence
extracellular 5
golgi apparatus 5
cytosol 4
nucleus 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for COPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 1429581
GO:0005737 cytoplasm IDA 9115636
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
GO:0030117 membrane coat --
genes like me logo Genes that share ontologies with COPA: view

Pathways for COPA Gene

genes like me logo Genes that share pathways with COPA: view

Gene Ontology (GO) - Biological Process for COPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS --
GO:0016192 vesicle-mediated transport --
GO:0030157 pancreatic juice secretion IDA 1429581
GO:0048205 COPI coating of Golgi vesicle TAS --
genes like me logo Genes that share ontologies with COPA: view

Compounds for COPA Gene

(1) HMDB Compounds for COPA Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1

(2) Novoseek inferred chemical compound relationships for COPA Gene

Compound -log(P) Hits PubMed IDs
copper 49.2 12
chloramphenicol 25.1 1
genes like me logo Genes that share compounds with COPA: view

Transcripts for COPA Gene

Alternative Splicing Database (ASD) splice patterns (SP) for COPA Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c ^
SP1: -
SP2:
SP3: -
SP4:
SP5: -
SP6: -
SP7: - - - -
SP8:
SP9: -
SP10:
SP11:
SP12: -

ExUns: 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for COPA Gene

GeneLoc Exon Structure for
COPA
ECgene alternative splicing isoforms for
COPA

Expression for COPA Gene

mRNA expression in normal human tissues for COPA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COPA Gene

SOURCE GeneReport for Unigene cluster for COPA Gene Hs.162121

mRNA Expression by UniProt/SwissProt for COPA Gene

P53621-COPA_HUMAN
Tissue specificity: Uniformly expressed in a wide range of adult and fetal tissues. Xenin is found in gastric, duodenal and jejunal mucosa. Circulates in the blood. Seems to be confined to specific endocrine cells
genes like me logo Genes that share expressions with COPA: view

Orthologs for COPA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for COPA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COPA 36
  • 99.78 (n)
  • 99.84 (a)
COPA 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia COPA 36
  • 93.27 (n)
  • 99.02 (a)
COPA 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COPA 36
  • 91.93 (n)
  • 98.43 (a)
COPA 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Copa 36
  • 91.07 (n)
  • 98.45 (a)
Copa 16
Copa 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia COPA 37
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COPA 37
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Copa 36
  • 91.23 (n)
  • 98.45 (a)
chicken
(Gallus gallus)
Aves COPA 36
  • 82.9 (n)
  • 96.57 (a)
COPA 37
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 80 (a)
OneToMany
-- 37
  • 97 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia copa 36
  • 80.83 (n)
  • 93.46 (a)
zebrafish
(Danio rerio)
Actinopterygii copa 36
  • 75.36 (n)
  • 86.75 (a)
copa 37
  • 87 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010251 36
  • 65.22 (n)
  • 72.03 (a)
fruit fly
(Drosophila melanogaster)
Insecta alphaCop 36
  • 66.01 (n)
  • 71.72 (a)
alphaCop 37
  • 71 (a)
OneToOne
alphaCop 38
  • 69 (a)
worm
(Caenorhabditis elegans)
Secernentea copa-1 37
  • 59 (a)
OneToOne
Y71F9AL.17 36
  • 60.18 (n)
  • 60.98 (a)
Y71F9AL.17 38
  • 64 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR077C 36
  • 50.88 (n)
  • 46.42 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COP1 36
  • 51.7 (n)
  • 45.9 (a)
COP1 37
  • 45 (a)
OneToMany
COP1 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F04884g 36
  • 52.22 (n)
  • 46.71 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G62020 36
  • 60.04 (n)
  • 57.23 (a)
rice
(Oryza sativa)
Liliopsida Os09g0127800 36
  • 59.47 (n)
  • 57.91 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU10066 36
  • 55.83 (n)
  • 51.85 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBPJ4664.04 36
  • 52.84 (n)
  • 48.99 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.184 37
  • 73 (a)
OneToOne
Species with no ortholog for COPA:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for COPA Gene

ENSEMBL:
Gene Tree for COPA (if available)
TreeFam:
Gene Tree for COPA (if available)

Paralogs for COPA Gene

Paralogs for COPA Gene

genes like me logo Genes that share paralogs with COPA: view

Variants for COPA Gene

Sequence variations from dbSNP and Humsavar for COPA Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1137943 -- 160,326,372(-) ttttt(A/G)tattt intron-variant
rs1137944 -- 160,326,292(-) gcctt(A/G)gcctc intron-variant
rs1137945 -- 160,326,276(-) GTGCT(A/G/T)GGATT intron-variant
rs1317944 -- 160,293,334(-) TGATT(A/G)GTATA intron-variant
rs1802778 -- 160,333,626(-) TGGAA(C/T)TGGCA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for COPA Gene

Variant ID Type Subtype PubMed ID
nsv3210 CNV Loss 18451855
esv272694 CNV Insertion 20981092

Relevant External Links for COPA Gene

HapMap Linkage Disequilibrium report
COPA

Disorders for COPA Gene

(1) Novoseek inferred disease relationships for COPA Gene

Disease -log(P) Hits PubMed IDs
hepatocellular carcinoma 5.76 1
genes like me logo Genes that share disorders with COPA: view

No data available for UniProtKB/Swiss-Prot for COPA Gene

Publications for COPA Gene

  1. HEP-COP, a novel human gene whose product is highly homologous to the alpha-subunit of the yeast coatomer protein complex. (PMID: 8647451) Chow V.T.K. … Quek H.H. (Gene 1996) 2 3 4 23
  2. Identification of xenin, a xenopsin-related peptide, in the human gastric mucosa and its effect on exocrine pancreatic secretion. (PMID: 1429581) Feurle G.E. … Metzger J.W. (J. Biol. Chem. 1992) 3 4 23
  3. Alpha coat protein COPA (HEP-COP): presence of an Alu repeat in cDNA and identity of the amino terminus to xenin. (PMID: 9365789) Chow V.T.K. … Quek H.H. (Ann. Hum. Genet. 1997) 3 4 23
  4. Xenin -- a review. (PMID: 9533652) Feurle G.E. (Peptides 1998) 3 4 23
  5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4

Products for COPA Gene

Sources for COPA Gene

Back to Top

Content