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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

COPA Gene

protein-coding GIFtS: 59
GCID: GC01M160258

coatomer protein complex, subunit alpha

Explore 10 diseases affiliated with
COPA via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Coatomer Protein Complex, Subunit Alpha¹ ²		Alpha-COP³
HEP-COP¹ ² ³		Coatomer Subunit Alpha²
Alpha-Coat Protein² ³		Xenin¹
HEPCOP² ³		Alpha-COP³
Alpha Coat Protein²

External Ids:	HGNC: 2230¹	Entrez Gene: 1314²	Ensembl: ENSG00000122218⁷	OMIM: 601924⁵	UniProtKB: P53621³

Export aliases for COPA gene to outside databases

Previous GC identifers: GC01M158051 GC01M155991 GC01M157036 GC01M157475 GC01M157072 GC01M158525 GC01M131615

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for COPA:

In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by

non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent

subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP,

delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1P, the

alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 amino acids of alpha-COP encode the bioactive

peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone. Alternative

splicing results in multiple splice forms encoding distinct isoforms. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: COPA_HUMAN, P53621

Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with

Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up

to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the

retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by

membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also

influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL

receptors (By similarity)

Function: Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to

induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts

with the neurotensin receptor

Gene Wiki entry for COPA

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the COPA gene promoter:
CUTL1 C/EBPalpha Meis-1b GATA-2 Evi-1 Meis-1a TGIF Pax-4a Meis-1 RSRFC4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: COPA promoter sequence

Search SABiosciences Chromatin IP Primers for COPA

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COPA

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.2 Ensembl cytogenetic band: 1q23.2 HGNC cytogenetic band: 1q23.2

COPA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COPA gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M160258: view genomic region (about GC identifiers)

Start:	160,258,377 bp from pter	End:	160,313,354 bp from pter
Size:	54,978 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: COPA_HUMAN, P53621 (See protein sequence)

Recommended Name: Coatomer subunit alpha

Size: 1224 amino acids; 138346 Da

Subunit: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.

Probably interacts with PEX11A. Interacts with SCYL1 (By similarity)

Subcellular location: Cytoplasm (By similarity). Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic

side (By similarity). Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side

(By similarity). Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on

the vesicles/buds originating from it (By similarity)

Subcellular location: Xenin: Secreted (By similarity)

Developmental stage: Xenin is released into the circulation after a meal

Rna editing: Modified_positions=164; Note=Edited at about 31%

Secondary accessions: Q5T201 Q8IXZ9

Alternative splicing: 2 isoforms: P53621-1 P53621-2

Explore the universe of human proteins at neXtProt for COPA: NX_P53621

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P53621

COPA Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001091868.1 NP_004362.2

ENSEMBL proteins:

ENSP00000357048 ENSP00000241704

Reactome Protein details: P53621
Human Recombinant Protein Products for COPA:

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	Novus Biologicals COPA Protein Novus Biologicals COPA Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	IDA	1429581
GO:0005737	cytoplasm	IDA	9115636
GO:0005829	cytosol	TAS	--
GO:0030126	COPI vesicle coat	ISS	--

COPA for ontologies About GeneDecksing

COPA Antibody Products:

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	ThermoFisher Antibody for COPA

Assay Products for COPA:

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	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
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	GenScript Custom Assay Services for COPA
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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

COPA for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR006692 Coatomer_WD-assoc_reg

IPR019775 WD40_repeat_CS

IPR016391 Coatomer_asu

IPR001680 WD40_repeat

IPR020472 G-protein_beta_WD-40_rep

Graphical View of Domain Structure for InterPro Entry P53621

ProtoNet protein and cluster: P53621

3 Blocks protein families:

IPB001680 G-protein beta WD-40 repeat signature

IPB006692 Coatomer WD associated region

IPB010714 Coatomer alpha subunit

UniProtKB/Swiss-Prot: COPA_HUMAN, P53621

Similarity: Contains 6 WD repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: COPA_HUMAN, P53621

Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with

Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up

to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the

retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by

membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also

influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL

receptors (By similarity)

Function: Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to

induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts

with the neurotensin receptor

Genatlas biochemistry entry for COPA:

Golgi coatomer complex alpha subunit,component of the coat of the non-clathrin-coated vesicles,expressed in a wide

range of fetal and adult tissues,homolog to the alpha subunit of S cerevisiae coatomer protein complex,involved in the

transport between the endoplasmic reticulum and Golgi

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005179	hormone activity	IEA	--
GO:0005198	structural molecule activity	IEA	--

COPA for ontologies About GeneDecksing

Phenotypes:
15 GenomeRNAi human phenotypes for COPA:

Decreased Hepatitis C virus re	Decreased Salmonella enterica	Decreased Salmonella-containin	Decreased Wnt reporter activit
Decreased cell number, increas	Decreased influenza A H1N1 (A/	Decreased influenza A H1N1 (A/	Decreased influenza A virus in
Decreased influenza A/WSN/33 r	Decreased viability of wild-ty	G0/1 arrest	Increased Salmonella enterica
Increased gamma-H2AX phosphory	Increased number of mitotic ce	Synthetic lethal with c-Myc af

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for COPA

miRNA Products:		OriGene 3'-UTR Clone (see all 2): COPA Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COPA
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate COPA:
		hsa-miR-579 hsa-miR-3148 hsa-miR-551b* hsa-miR-1253
		SwitchGear 3'UTR luciferase reporter plasmid: COPA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPA

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Coatomer:Arf1-GTP:GAP lattice formation on golgi membrane

Coatomer:Arf1-GTP:GAP lattice formation on golgi membrane	1.00	COPI Mediated Transport	0.90
Hydrolysis of Arf1-GTP to Arf1-GDP	1.00	Golgi vesicle lattice disassociation	0.89
Diffusion of inactive Arf1-GDP from membrane	1.00	Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF)	0.32
Golgi to ER Retrograde Transport	0.90

Clathrin-dependent protein traffic

	Clathrin-dependent protein traffic	1.00			wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)	0.37
	Transport_Clathrin-coated vesicle cycle	0.66

COPII (Coat Protein 2) Mediated Vesicle Transport

Normal wtCFTR traffic / ER-to-Golgi

0.36

Delta508-CFTR traffic / ER-to-Golgi in CF

0.36

Membrane Trafficking

Membrane Trafficking

1.00

C-MYB transcription factor network

C-MYB transcription factor network

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for COPA

Clathrin-dependent protein traffic

5 GeneGo (Thomson Reuters) Pathways for COPA

	wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
	Delta508-CFTR traffic / ER-to-Golgi in CF
	Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF)
	Normal wtCFTR traffic / ER-to-Golgi
	Transport Clathrin-coated vesicle cycle

2 BioSystems Pathways for COPA

	Arf1 pathway
	C-MYB transcription factor network

5/7 Reactome Pathways for COPA (see all 7)

	Hydrolysis of Arf1-GTP to Arf1-GDP
	Diffusion of inactive Arf1-GDP from membrane
	Membrane Trafficking
	COPI Mediated Transport
	Golgi to ER Retrograde Transport

COPA for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for COPA

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/1010 Interacting proteins for COPA (P53621^{2, 3} ENSP00000357048⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 1010)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ARCN1	P48444²^,³, ENSP00000264028⁴	MINT-7945693 MINT-8217717 MINT-7947479 I2D: score=7 STRING: ENSP00000264028
COPB1	P53618²^,³, ENSP00000249923⁴	MINT-7945693 MINT-8217717 MINT-7947479 I2D: score=7 STRING: ENSP00000249923
COPE	O14579²^,³, ENSP00000262812⁴	MINT-8217717 MINT-63065 I2D: score=7 STRING: ENSP00000262812
COPB2	P35606²^,³, ENSP00000329419⁴	MINT-7945693 MINT-7947479 I2D: score=3 STRING: ENSP00000329419
RPL31	P62899²^,³	MINT-7945693 MINT-6489355 MINT-7947479 I2D: score=1

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006886	intracellular protein transport	IEA	--
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	TAS	--
GO:0016044	cellular membrane organization	TAS	--
GO:0030157	pancreatic juice secretion	IDA	1429581
GO:0048205	COPI coating of Golgi vesicle	TAS	--

COPA for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

COPA for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for COPA

1 HMDB Compound for COPA About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

2 Novoseek chemical compound relationships for COPA gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
copper	49.2	17	10639134 (4), 17696885 (2), 9398888 (2), 11500054 (1) (see all 7)
chloramphenicol	25.1	1	11031122 (1)

Search CenterWatch for drugs/clinical trials and news about COPA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for COPA gene (2 alternative transcripts):

NM_001098398.1 NM_004371.3

Unigene Clusters for COPA:

Coatomer protein complex, subunit alpha

Hs.162121 [show with all ESTs], Hs.685025

Unigene Representative Sequences: NM_001098398, BC037941

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000368069 ENST00000241704(uc009wti.3 uc001fvv.4 uc009wtj.1)

ENST00000545284 ENST00000481522 ENST00000481040 ENST00000541366 ENST00000545266

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		hsa-miR-579 hsa-miR-3148 hsa-miR-551b* hsa-miR-1253
		SwitchGear 3'UTR luciferase reporter plasmid: COPA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COPA (see all 7) OriGene shRNA RFP: COPA OriGene siRNA: COPA
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		Sirion Biotech Custom design and validation of potent shRNA sequences against COPA

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		GenScript: all cDNA clones in your preferred vector (see all 2): COPA (NM_004371)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COPA

Additional cDNA sequence: BC037941.2

24/39 DOTS entries (see all 39):

DT.92354410 DT.422143 DT.95266247 DT.121428648 DT.95266251 DT.100795668 DT.95266229 DT.91764888

DT.121428676 DT.100001009 DT.121428684 DT.97774102 DT.99965931 DT.121428771 DT.121428772 DT.91707646

DT.100795664 DT.95332895 DT.95316196 DT.97792442 DT.99970079 DT.100658439 DT.121428646 DT.121428719

24/602 AceView cDNA sequences (see all 602):

BE384317 BE206080 AU124944 BM838159 AI023311 BE397260 BE895978 AK129830

AA452297 AI500691 CA777639 AU133019 BM755786 CD679293 BQ689531 BQ477458

BE336825 BP379096 BP358884 AA333048 AU125891 BP362981 CA848348 BM478131

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for COPA (see all 12) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	·	3c	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9a	·	9b	^	10a	·	10b	^	11a	·	11b	^	12a	·	12b	^	13a	·	13b	^	14a	·	14b	·	14c	^
SP1:																																			-
SP2:
SP3:																																			-
SP4:
SP5:																																			-

ExUns:	15a	·	15b	^	16	^	17	^	18a	·	18b	^	19	^	20	^	21	^	22a	·	22b	^	23	^	24
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for COPA

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

COPA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCTGGGAAA

About this image
See COPA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for COPA

SOURCE GeneReport for Unigene clusters: Hs.162121 Hs.685025

UniProtKB/Swiss-Prot: COPA_HUMAN, P53621

Tissue specificity: Uniformly expressed in a wide range of adult and fetal tissues. Xenin is found in gastric, duodenal

and jejunal mucosa. Circulates in the blood. Seems to be confined to specific endocrine cells

SABiosciences Custom PCR Arrays for COPA

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COPA

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COPA

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for COPA gene from 8/32 species (see all 32) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	COPA¹	coatomer protein complex, subunit alpha	82.9(n) 96.57(a)		426906 NM_001031405.1 NP_001026576.1
lizard (Anolis carolinensis)	Reptilia	--	--	85(a)	1 ↔ 1	GL343878.1(128684-144893)
zebrafish (Danio rerio)	Actinopterygii	copa¹	coatomer protein complex, subunit alpha	75.36(n) 86.75(a)		260439 NM_001001941.2 NP_001001941.2
fruit fly (Drosophila melanogaster)	Insecta	alphaCop^{1 , 3}	retrograde (Golgi to ER) transport³ alpha-coatomer protein¹	69(a)³ 66.2(n)¹ 71.94(a)¹		62A9³ 38199¹ NM_167908.2¹ NP_728648.1¹
worm (Caenorhabditis elegans)	Secernentea	Y71F9AL.17^{1 , 3}	coatomer, alpha chain³ Protein Y71F9AL.17¹	64(a)³ 60.18(n)¹ 60.98(a)¹		I(2895563-2900802)³ 171860¹ NM_058668.4¹ NP_491069.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	COP1(YDL145C)⁴ COP1¹	Alpha subunit of COPI vesicle coatomer complex, which more⁴ Cop1p¹	51.58(n)¹ 45.78(a)¹		4(198176-194571)⁴ 851410^{1, 4} NP_010136.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	AT2G21390¹	coatomer subunit alpha-2	59.15(n) 56.79(a)		816678 NM_127711.3 NP_179734.1
rice (Oryza sativa)	Liliopsida	Os09g0127800¹	hypothetical protein	59.32(n) 57.35(a)		4346440 NM_001069147.1 NP_001062612.1

ENSEMBL Gene Tree for COPA (if available)
TreeFam Gene Tree for COPA (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs78998321^1,2		--	131667335(+)	`TATTAC/TTCTAA`	1	--	us2k¹		0	--	--	--	--
rs74123124^1,2	C	--	131668071(+)	`TAATAC/TTCTCT`	1	--	us2k¹		1		WA	2
rs60130110^1,2	C,F	--	131668270(+)	`TCGGAG/AACCTT`	1	--	us2k¹		3		WA CSA	122
rs73029437^1,2	C,F	--	131668575(+)	`AAGCCG/TAATGG`	1	--	us2k¹		7		WA CSA NA EA	364
rs73029438^1,2	C,F	--	131668638(+)	`CTACTC/TGNNNN`	1	--	us2k¹		4		WA CSA EA	242
rs111932252^1,2		--	131668676(+)	`TAACAG/CAGATC`	1	--	us2k¹		2		CSA WA	120
rs111711203^1,2	C	--	131668760(+)	`AGAACC/AACACA`	1	--	us2k¹		1		WA	2
rs1324738^1,2	C,F,H	--	131668762(-)	`TTTGTG/ATTGTT`	1	--	us2k¹		28		MN NS EA NA WA CSA	2958
rs189765395^1,2	C	--	131669175(+)	`TCAGCA/G/TACCCT`	1	--	us2k¹		0	--	--	--	--
rs3737794^1,2	C,F	--	131669467(+)	`CCCCGC/GCGCGA`	1	--	int¹		7		EA WA CSA NA	1740

HapMap Linkage Disequilibrium report for COPA (160258377 - 160313354 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for COPA: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COPA

DNA2.0 Custom Variant and Variant Library Synthesis for COPA

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

COPA for disorders           About GeneDecksing

OMIM gene information: 601924    OMIM disorders: --

10 diseases for COPA:    About MalaCards

pancreatitis menkes disease wilson disease neuroendocrine tumor

hepatocellular carcinoma duodenitis carcinoma cholesterol

malaria neuronitis

1 Novoseek disease relationship for COPA gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hepatocellular carcinoma	5.76	1	9115636 (1)

Export disorders for COPA gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for COPA gene, integrated from 9 sources (see all 93):
(articles sorted by number of sources associating them with COPA)

Utopia: connect your pdf to the dynamic
world of online information

HEP-COP, a novel human gene whose product is highly homologous to the alpha-subunit of the yeast coatomer protein complex. (PubMed id 8647451)^{1, 2, 3, 9} Chow V.T.K. and Quek H.H. (1996)
Xenin -- a review. (PubMed id 9533652)^{1, 2, 9} Feurle G.E. (1998)
Alpha coat protein COPA (HEP-COP): presence of an Alu repeat in cDNA and identity of the amino terminus to xenin. (PubMed id 9365789)^{1, 2, 9} Chow V.T.K. and Quek H.H. (1997)
Identification of xenin, a xenopsin-related peptide, in the human gastric mucosa and its effect on exocrine pancreatic secretion. (PubMed id 1429581)^{1, 2, 9} Feurle G.E.... Metzger J.W. (1992)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{1, 2} Beausoleil S.A.... Gygi S.P. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Genomic organization and mapping of the human HEP-COP gene (COPA) to 1q. (PubMed id 9186507)^{1, 9} Quek H.H. and Chow V.T. (1997)
Molecular and cellular studies of the human homolog of the 160-kD alpha-subunit of the coatomer protein complex. (PubMed id 9115636)^{1, 9} Quek H.H. and Chow V.T. (1997)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Protein interaction profiling of the p97 adaptor UBXD1 points to a role for the complex in modulating ERGIC-53 trafficking. (PubMed id 22337587)¹ Haines D.S....Deshaies R.J. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1314	HGNC: 2230	AceView: COPA	Ensembl:ENSG00000122218	euGenes: HUgn1314
ECgene: COPA	H-InvDB: COPA

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for COPA	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Xenin

Intellectual Property for COPA gene
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Patent Information for COPA gene:
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GeneCards and IP:
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coatomer protein complex, subunit alpha

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