COMTD1 Gene
protein-coding GIFtS: 43
GCID: GC10M076993
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|
catechol-O-methyltransferase domain containing 1
| |
Aliases
for COMTD1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Catechol-O-Methyltransferase Domain Containing 11 2 | | FLJ238411 | | Catechol O-Methyltransferase Domain-Containing Protein 12 | | EC 2.1.1.-3 |
Export aliases for COMTD1 gene to outside databasesPrevious GC identifers: GC10M076339 GC10M076663 GC10M070992 |
Summaries
for COMTD1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CMTD1_HUMAN, Q86VU5Function: Putative O-methyltransferase (Potential)
|
Genomic Views
for COMTD1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the COMTD1 gene promoter:
FOXD1 CUTL1 E47 Roaz FOXJ2 (long isoform) SEF-1 (1) Hand1 ZID FOXJ2 MRF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for COMTD1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COMTD1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q22.2 Ensembl cytogenetic band: 10q22.2 HGNC chromosome: 10COMTD1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M076993: view genomic region
(about GC identifiers)
Start:
|
76,993,727 bp from pter |
End:
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76,995,788 bp from pter |
Size:
|
2,062 bases |
Orientation:
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minus strand |
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Proteins
for COMTD1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CMTD1_HUMAN, Q86VU5 (See
protein sequence)Recommended Name: Catechol O-methyltransferase domain-containing protein 1 Size: 262 amino acids; 28809 Da
Subunit: Homodimer
Subcellular location: Membrane; Single-pass type II membrane protein (Potential)
1 PDB 3D structure from  and Proteopedia  for COMTD1:2AVD (3D)
Secondary accessions: Q8TE79Explore the universe of human proteins at neXtProt for COMTD1: NX_Q86VU5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86VU5
COMTD1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_653190.2
ENSEMBL proteins: ENSP00000361616
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
COMTD1 for ontologies About GeneDecksing
COMTD1 Antibody Products:
Assay Products for COMTD1: |
Protein
Domains /
Families
for COMTD1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
COMTD1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q86VU5ProtoNet protein and cluster: Q86VU5 1 Blocks protein family: IPB002935 O-methyltransferase
UniProtKB/Swiss-Prot: CMTD1_HUMAN, Q86VU5Similarity: Belongs to the methyltransferase superfamily. Type 3 family |
Function
for COMTD1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CMTD1_HUMAN, Q86VU5Function: Putative O-methyltransferase (Potential)Enzyme Number (IUBMB): EC 2.1.1.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COMTD1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COMTD1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: COMTD1 (NM_144589) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COMTD1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COMTD1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008171 | O-methyltransferase activity |
IEA | -- |
COMTD1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for COMTD1:
|
Pathways & Interactions
for COMTD1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for COMTD1
|
Drugs & Compounds
for COMTD1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for COMTD1
3 DrugBank Compounds for COMTD1 About this table
Search CenterWatch for drugs/clinical trials and news about COMTD1 / CMTD1
|
Transcripts
for COMTD1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for COMTD1 gene: NM_144589.2 Unigene Cluster for COMTD1: Catechol-O-methyltransferase domain containing 1 Hs.355333 [show with all ESTs]Unigene Representative Sequence: AK3022837 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000372538(uc001jxb.3) ENST00000460899 ENST00000494596 ENST00000469299
ENST00000470947 ENST00000490521 ENST00000491270
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COMTD1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COMTD1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: COMTD1 (NM_144589) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COMTD1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COMTD1 |
Additional cDNA sequence: AK074421.1 AK290452.1 AK302283.1 AY358476.1 BC023663.2 BC047774.1 6 DOTS entries: DT.309622 DT.100779861 DT.95161402 DT.91745036 DT.99968497 DT.95161403 24/102 AceView cDNA sequences (see all 102): BI832844 CD674768 F36954 AY358476 BM768764 BG680071 CR625911 BM141962 CA395926 CB852030 CK819655 NM_144589 BM769685 BG285119 AW157329 BC047774 BQ082692 AW163255 CR602194 BM451059 BM856156 BM826016 BQ083301 BM976177
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for COMTD1 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c |
|---|
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| SP1: | | | | | | | | | | | - | | | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | - | | - | | - | | - | | - | | - | | | | | | - | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for COMTD1
|
Expression
for COMTD1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| COMTD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGGGAGCACC
About this image
See COMTD1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for COMTD1
SOURCE GeneReport for Unigene cluster: Hs.355333
SABiosciences Custom PCR Arrays for COMTD1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COMTD1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat COMTD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COMTD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COMTD1 |
Orthologs
for COMTD1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for COMTD1 gene from 7/25 species (see all 25) About this table
ENSEMBL Gene Tree for COMTD1 (if available)
TreeFam Gene Tree for COMTD1 (if available) |
Paralogs
for COMTD1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for COMTD1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for COMTD1 (76993727 - 76995788 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for COMTD1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COMTD1 |
|
Disorders
/ Diseases
for COMTD1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
COMTD1 for disorders About GeneDecksing
5  diseases for COMTD1: About MalaCardshomocysteine alzheimer's disease pneumonia tuberculosis
mycobacterium tuberculosis
Human Genome Epidemiology (HuGE) Navigator: COMTD1 (2 documents)
Export disorders for COMTD1 gene to outside databases
|
Publications
for COMTD1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for COMTD1 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with COMTD1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Genetic variants associated with breast size also infl uence breast cancer risk. (PubMed id 22747683)1 Eriksson N....Tung J.Y. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)7 Imming P....Meyer A. (2006)
- A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (2006)
|
External Searches for COMTD1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing COMTD1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing COMTD1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing COMTD1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for COMTD1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for COMTD1 gene:
Search GeneIP for patents involving COMTD1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for COMTD1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for COMTD1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COMTD1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COMTD1 | | | OriGene Protein Over-expression Lysate for COMTD1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for COMTD1 | | OriGene 3'-UTR Clone for COMTD1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COMTD1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COMTD1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for COMTD1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for COMTD1 | | OriGene Custom Protein Services for COMTD1 | | | OriGene Custom Immunoassay Development | | |
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 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat COMTD1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COMTD1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COMTD1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COMTD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COMTD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COMTD1 |
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 |  |  |  | |
| | | | Search Tocris compounds for COMTD1 |
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 | | | COMTD1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for COMTD1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COMTD1 |
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