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COMTD1 Gene

protein-coding   GIFtS: 49
GCID: GC10M076993

Catechol-O-Methyltransferase Domain Containing 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Catechol-O-Methyltransferase Domain Containing 11 2
Catechol O-Methyltransferase Domain-Containing Protein 12
EC 2.1.1.-3

External Ids:    HGNC: 263091   Entrez Gene: 1188812   Ensembl: ENSG000001656447   UniProtKB: Q86VU53   
ORGUL members:         

Export aliases for COMTD1 gene to outside databases

Previous GC identifers: GC10M076339 GC10M076663 GC10M070992


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for COMTD1 Gene:
COMTD1 (catechol-O-methyltransferase domain containing 1) is a protein-coding gene. Diseases associated with COMTD1 include pneumonia, and tuberculosis. GO annotations related to this gene include O-methyltransferase activity.

UniProtKB/Swiss-Prot: CMTD1_HUMAN, Q86VU5
Function: Putative O-methyltransferase (Potential)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the COMTD1 gene promoter:
         FOXD1   CUTL1   E47   Roaz   FOXJ2 (long isoform)   SEF-1 (1)   Hand1   ZID   FOXJ2   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOMTD1 promoter sequence
   Search Chromatin IP Primers for COMTD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COMTD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22.2   Ensembl cytogenetic band:  10q22.2   HGNC cytogenetic band: 10q22.2

COMTD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COMTD1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M076993:  view genomic region     (about GC identifiers)

Start:
76,993,727 bp from pter      End:
76,995,788 bp from pter
Size:
2,062 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CMTD1_HUMAN, Q86VU5 (See protein sequence)
Recommended Name: Catechol O-methyltransferase domain-containing protein 1  
Size: 262 amino acids; 28809 Da
Subunit: Homodimer
1 PDB 3D structure from and Proteopedia for COMTD1:
2AVD (3D)    
Secondary accessions: Q8TE79

Explore the universe of human proteins at neXtProt for COMTD1: NX_Q86VU5

Explore proteomics data for COMTD1 at MOPED


See COMTD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_653190.2  
ENSEMBL proteins: 
 ENSP00000361616   ENSP00000473626  

COMTD1 Human Recombinant Protein Products:

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Novus Biologicals COMTD1 Protein
Novus Biologicals COMTD1 Lysates
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Cloud-Clone Corp. Proteins for COMTD1

COMTD1 Antibody Products:

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OriGene Custom Antibody Services for COMTD1
Novus Biologicals COMTD1 Antibodies
Abcam antibodies for COMTD1
Cloud-Clone Corp. Antibodies for COMTD1
Search ThermoFisher Antibodies for COMTD1
LSBio Antibodies in human, mouse, rat for COMTD1

COMTD1 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for COMTD1
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for COMTD1
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for COMTD1
Cloud-Clone Corp. CLIAs for COMTD1


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR002935 O-MeTrfase_3

Graphical View of Domain Structure for InterPro Entry Q86VU5

ProtoNet protein and cluster: Q86VU5

1 Blocks protein domain: IPB002935 O-methyltransferase

UniProtKB/Swiss-Prot: CMTD1_HUMAN, Q86VU5
Similarity: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent
O-methyltransferase family


COMTD1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: CMTD1_HUMAN, Q86VU5
Function: Putative O-methyltransferase (Potential)

     Enzyme Number (IUBMB): EC 2.1.1.-1

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008171O-methyltransferase activity IEA--
     
COMTD1 for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for COMTD1:
 Decreased cilium length  Decreased cilium length after  

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for COMTD1
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for COMTD1

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for COMTD1
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for COMTD1

miRNA
Products:
    
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Search for qRT-PCR Assays for microRNAs that regulate COMTD1
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for COMTD1
Predesigned siRNA for gene silencing in human, mouse, rat COMTD1

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for COMTD1

Clone
Products:
     
OriGene clones in human, mouse for COMTD1 (see all 6)
OriGene ORF clones in mouse, rat for COMTD1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: COMTD1 (NM_144589)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for COMTD1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COMTD1

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for COMTD1
Browse ESI BIO Cell Lines and PureStem Progenitors for COMTD1 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COMTD1


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
CMTD1_HUMAN, Q86VU5: Membrane; Single-pass type II membrane protein (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular2
mitochondrion2
cytosol1
golgi apparatus1
lysosome1
peroxisome1
plasma membrane1
vacuole1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion IEA--
GO:0016021integral component of membrane IEA--

COMTD1 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for COMTD1
Interactions:

    Search GeneGlobe Interaction Network for COMTD1

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

Selected Interacting proteins for COMTD1 (ENSP000003616164) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
InteractantInteraction Details
GeneCardExternal ID(s)
CIAPIN1ENSP000003779144STRING: ENSP00000377914
EIF3MENSP000003199104STRING: ENSP00000319910
MINOS1ENSP000003255624STRING: ENSP00000325562
MLYCDENSP000002624304STRING: ENSP00000262430
NSRP1ENSP000002470264STRING: ENSP00000247026
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for COMTD1 (CMTD1)

3 DrugBank Compounds for COMTD1    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
Feruloyl Coenzyme A-- --target--17139284 17016423 10592235
S-Adenosyl-L-Homocysteine-- 979-92-0target--17139284 17016423 10592235
Sinapoyl Coenzyme A-- --target--17139284 17016423 10592235



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for COMTD1 gene: 
NM_144589.2  

Unigene Cluster for COMTD1:

Catechol-O-methyltransferase domain containing 1
Hs.355333  [show with all ESTs]
Unigene Representative Sequence: AK302283
7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000372538(uc001jxb.3) ENST00000460899 ENST00000494596 ENST00000470947
ENST00000469299 ENST00000490521 ENST00000491270
miRNA
Products:
     
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Search for qRT-PCR Assays for microRNAs that regulate COMTD1
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for COMTD1
Predesigned siRNA for gene silencing in human, mouse, rat COMTD1
Clone
Products:
     
OriGene clones in human, mouse for COMTD1 (see all 6)
OriGene ORF clones in mouse, rat for COMTD1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: COMTD1 (NM_144589)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for COMTD1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COMTD1
Primer
Products:
    
OriGene qPCR primer pairs and template standards for COMTD1
OriGene qSTAR qPCR primer pairs in human, mouse for COMTD1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat COMTD1
  QuantiTect SYBR Green Assays in human, mouse, rat COMTD1
  QuantiFast Probe-based Assays in human, mouse, rat COMTD1

Additional mRNA sequence: 

AK074421.1 AK290452.1 AK302283.1 AY358476.1 BC023663.2 BC047774.1 

6 DOTS entries:

DT.309622  DT.100779861  DT.95161402  DT.91745036  DT.99968497  DT.95161403 

Selected AceView cDNA sequences (see all 102):

BM826016 BM768764 BQ082692 BM451059 CD674768 BM825668 CK819655 BC047774 
AW163255 F36954 BG680071 CR602194 NM_144589 BG285119 AW157329 BM769685 
CR625911 BC023663 BI832844 BM856156 CA395926 AA618529 AY358476 CB852030 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for COMTD1 (see all 6)    About this scheme

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1:                                -                                   -                     
SP2:                                                                    -                     
SP3:                    -     -     -     -     -     -                 -                     
SP4:                                -                                                         
SP5:                                                                                          


ECgene alternative splicing isoforms for COMTD1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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COMTD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CGGGAGCACC
COMTD1 Expression
About this image


COMTD1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 3) fully expand
 
 Brain (Nervous System)    fully expand to see all 2 entries
         Cerebral Cortex
 
 Neural Tube (Nervous System)
         Telencephalon
 
 Liver (Hepatobiliary System)
COMTD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

COMTD1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.355333
    Custom PCR Arrays for COMTD1
Primer
Products:
OriGene qPCR primer pairs and template standards for COMTD1
OriGene qSTAR qPCR primer pairs in human, mouse for COMTD1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat COMTD1
QuantiTect SYBR Green Assays in human, mouse, rat COMTD1
QuantiFast Probe-based Assays in human, mouse, rat COMTD1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COMTD1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for COMTD1 gene from Selected species (see all 17)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Comtd11 , 5 catechol-O-methyltransferase domain containing 11, 5 84.22(n)1
85.5(a)1
  14 (11.92 cM)5
691561  NM_026965.21  NP_081241.11 
 218458615 
chicken
(Gallus gallus)
Aves COMTD11 catechol-O-methyltransferase domain containing 1 54.56(n)
52.14(a)
  423730  XM_421605.4  XP_421605.4 
lizard
(Anolis carolinensis)
Reptilia COMTD16
catechol-O-methyltransferase domain containing 1
43(a)
1 ↔ 1
GL343196.1(2723060-2753934)
zebrafish
(Danio rerio)
Actinopterygii comtd11 catechol-O-methyltransferase domain containing 1 55.13(n)
50.71(a)
  568094  NM_001163808.1  NP_001157280.1 
worm
(Caenorhabditis elegans)
Secernentea comt-51 comt-5 47.19(n)
43.98(a)
  178684  NM_071158.4  NP_503559.2 
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G619901 AT3G61990 46.24(n)
39.22(a)
  825372  NM_116064.4  NP_191758.1 
rice
(Oryza sativa)
Liliopsida Os08g01540001 Os08g0154000 46.51(n)
40(a)
  4344681  NM_001067547.1  NP_001061012.1 


ENSEMBL Gene Tree for COMTD1 (if available)
TreeFam Gene Tree for COMTD1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for COMTD1 (see all 107)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 10 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1170963951,2
F--76993352(+) GCCGCC/TAGCAG 1 -- int11Minor allele frequency- T:0.03EA 120
rs732810221,2
C--76993395(+) CACCCG/ATGGTC 1 -- int14Minor allele frequency- A:0.22WA NA EA 360
rs1897516301,2
--76993461(+) AGCTGC/TTCAGA 1 -- int10--------
rs1440422491,2
--76993581(+) CCTCCC/TGCCAG 1 -- int10--------
rs1831344551,2
--76993597(+) GGTTCC/GTGCAG 1 -- int10--------
rs1398967551,2
--76993598(+) GTTCCG/TGCAGT 1 -- int10--------
rs1882206551,2
--76993626(+) GCCAGA/GGAGGG 1 -- int10--------
rs1917725521,2
--76993627(+) CCAGGC/GAGGGG 1 -- int10--------
rs1834721831,2
--76993750(+) CACTTC/TATTTT 1 -- ut310--------
rs10543211,2
C--76993885(-) AGGGTC/TTACAT 2 V syn1 ese33Minor allele frequency- T:0.00MN NA 188

HapMap Linkage Disequilibrium report for COMTD1 (76993727 - 76995788 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for COMTD1:    About this table    
Variant IDTypeSubtypePubMed ID
nsv831913CNV Loss17160897

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing COMTD1
DNA2.0 Custom Variant and Variant Library Synthesis for COMTD1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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5 diseases for COMTD1:    
About MalaCards
pneumonia    tuberculosis    alzheimer's disease    cerebritis
breast cancer


COMTD1 for disorders           About GeneDecksing

Genetic Association Database (GAD): COMTD1
Human Genome Epidemiology (HuGE) Navigator: COMTD1 (2 documents)

Export disorders for COMTD1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for COMTD1 gene, integrated from 10 sources (see all 14):
(articles sorted by number of sources associating them with COMTD1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (Genome Res. 2003)
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  6. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
  7. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
  8. Genetic variants associated with breast size also influence breast cancer risk. (PubMed id 22747683)1 Eriksson N....Tung J.Y. (BMC Med. Genet. 2012)
  9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
  10. Drugs, their targets and the nature and number of drug targets. (PubMed id 17016423)7 Imming P....Meyer A. (Nat Rev Drug Discov 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 118881 HGNC: 26309 AceView: COMTD1 Ensembl:ENSG00000165644 euGenes: HUgn118881
ECgene: COMTD1 H-InvDB: COMTD1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for COMTD1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for COMTD1 gene:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 EMD Millipore genomic analysis products

  
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 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for COMTD1  
 OriGene qPCR primer pairs and template standards for COMTD1   OriGene Protein Over-expression Lysate for COMTD1  
 OriGene MassSpec something-or-other for COMTD1   OriGene clones in human, mouse for COMTD1  
 OriGene qSTAR qPCR primer pairs in human, mouse for COMTD1   OriGene Purified Protein for COMTD1  
 OriGene ORF clones in mouse, rat for COMTD1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for COMTD1   OriGene Custom Protein Services for COMTD1  

 
 
 Block miRNA regulation of human, mouse, rat COMTD1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing COMTD1
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COMTD1 Predesigned siRNA for gene silencing in human, mouse, rat COMTD1
 QuantiFast Probe-based Assays in human, mouse, rat COMTD1 QuantiTect SYBR Green Assays in human, mouse, rat COMTD1
 Custom PCR Arrays for COMTD1 Search Chromatin IP Primers for COMTD1
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat COMTD1  Search GeneGlobe Interaction Network for COMTD1
 Regulatory tfbs in COMTD1 promoter
 GenScript Custom Purified and Recombinant Proteins Services for COMTD1 GenScript cDNA clones with any tag delivered in your preferred vector for COMTD1
 GenScript Custom Assay Services for COMTD1 GenScript Custom overexpressing Cell Line Services for COMTD1
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
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 Search Tocris compounds for COMTD1 (CMTD1)
 Browse Sino Biological Proteins
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 Protein Production Services
 Transfection Reagents
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 COMTD1 antibodies
 COMTD1 proteins
 COMTD1 lysates
 Antibodies for COMTD1
 See all of Abcam's Antibodies, Kits and Proteins for COMTD1
 Custom Antibody / Protein Production Service
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 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Proteins for COMTD1
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 ELISAs for COMTD1
 CLIAs for COMTD1



 Browse ESI BIO Cell Lines and PureStem Progenitors for COMTD1
 Gene Synthesis
 Protein Engineering
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 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COMTD1
 Browse SwitchGear 3'UTR luciferase reporter plasmids for COMTD1
 SwitchGear Promoter luciferase reporter plasmids for COMTD1
 Search ThermoFisher Antibodies for COMTD1
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COMTD1
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for COMTD1
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for COMTD1
 LSBio Antibodies in human, mouse, rat for COMTD1
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
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 Browse compounds at ApexBio
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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