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Aliases for COMTD1 Gene

Aliases for COMTD1 Gene

  • Catechol-O-Methyltransferase Domain Containing 1 2 3
  • EC 2.1.1.- 4

External Ids for COMTD1 Gene

Previous GeneCards Identifiers for COMTD1 Gene

  • GC10M076339
  • GC10M076663
  • GC10M076993
  • GC10M070992

Summaries for COMTD1 Gene

GeneCards Summary for COMTD1 Gene

COMTD1 (Catechol-O-Methyltransferase Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include O-methyltransferase activity.

UniProtKB/Swiss-Prot for COMTD1 Gene

  • Putative O-methyltransferase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COMTD1 Gene

Genomics for COMTD1 Gene

Regulatory Elements for COMTD1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for COMTD1 Gene

Start:
75,233,969 bp from pter
End:
75,236,030 bp from pter
Size:
2,062 bases
Orientation:
Minus strand

Genomic View for COMTD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COMTD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COMTD1 Gene

Proteins for COMTD1 Gene

  • Protein details for COMTD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VU5-CMTD1_HUMAN
    Recommended name:
    Catechol O-methyltransferase domain-containing protein 1
    Protein Accession:
    Q86VU5
    Secondary Accessions:
    • Q8TE79

    Protein attributes for COMTD1 Gene

    Size:
    262 amino acids
    Molecular mass:
    28809 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for COMTD1 Gene

neXtProt entry for COMTD1 Gene

Proteomics data for COMTD1 Gene at MOPED

Post-translational modifications for COMTD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for COMTD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for COMTD1 Gene

Domains for COMTD1 Gene

Protein Domains for COMTD1 Gene

Suggested Antigen Peptide Sequences for COMTD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q86VU5

UniProtKB/Swiss-Prot:

CMTD1_HUMAN :
  • Q86VU5
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
genes like me logo Genes that share domains with COMTD1: view

No data available for Gene Families for COMTD1 Gene

Function for COMTD1 Gene

Molecular function for COMTD1 Gene

UniProtKB/Swiss-Prot Function: Putative O-methyltransferase.

Enzyme Numbers (IUBMB) for COMTD1 Gene

Gene Ontology (GO) - Molecular Function for COMTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008171 O-methyltransferase activity IEA --
genes like me logo Genes that share ontologies with COMTD1: view

Phenotypes for COMTD1 Gene

genes like me logo Genes that share phenotypes with COMTD1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COMTD1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for COMTD1 Gene

Localization for COMTD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COMTD1 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COMTD1 Gene COMPARTMENTS Subcellular localization image for COMTD1 gene
Compartment Confidence
extracellular 2
mitochondrion 2
cytosol 1
golgi apparatus 1
lysosome 1
peroxisome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for COMTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with COMTD1: view

Pathways for COMTD1 Gene

SuperPathways for COMTD1 Gene

No Data Available

Interacting Proteins for COMTD1 Gene

Gene Ontology (GO) - Biological Process for COMTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with COMTD1: view

No data available for Pathways by source for COMTD1 Gene

Compounds for COMTD1 Gene

(3) Drugbank Compounds for COMTD1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Feruloyl Coenzyme A
target
S-Adenosyl-L-Homocysteine
979-92-0 target
Sinapoyl Coenzyme A
target
genes like me logo Genes that share compounds with COMTD1: view

Transcripts for COMTD1 Gene

Unigene Clusters for COMTD1 Gene

Catechol-O-methyltransferase domain containing 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COMTD1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COMTD1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - -
SP2: -
SP3: - - - - - - -
SP4: -
SP5:
SP6:

Relevant External Links for COMTD1 Gene

GeneLoc Exon Structure for
COMTD1
ECgene alternative splicing isoforms for
COMTD1

Expression for COMTD1 Gene

mRNA expression in normal human tissues for COMTD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for COMTD1 Gene

This gene is overexpressed in Pancreas (6.9) and Esophagus - Mucosa (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COMTD1 Gene

SOURCE GeneReport for Unigene cluster for COMTD1 Gene Hs.355333

genes like me logo Genes that share expressions with COMTD1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for COMTD1 Gene

Orthologs for COMTD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for COMTD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COMTD1 35
  • 99.49 (n)
  • 99.62 (a)
COMTD1 36
  • 56 (a)
OneToOne
cow
(Bos Taurus)
Mammalia COMTD1 35
  • 85.5 (n)
  • 88.17 (a)
COMTD1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COMTD1 35
  • 88.55 (n)
  • 87.4 (a)
COMTD1 36
  • 49 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Comtd1 35
  • 84.22 (n)
  • 85.5 (a)
Comtd1 16
Comtd1 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia COMTD1 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COMTD1 36
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Comtd1 35
  • 84.35 (n)
  • 86.26 (a)
chicken
(Gallus gallus)
Aves COMTD1 35
  • 54.56 (n)
  • 52.14 (a)
COMTD1 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COMTD1 36
  • 43 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8831 35
zebrafish
(Danio rerio)
Actinopterygii comtd1 35
  • 55.13 (n)
  • 50.71 (a)
comtd1 36
  • 40 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea comt-1 36
  • 12 (a)
OneToMany
comt-2 36
  • 37 (a)
OneToMany
comt-3 36
  • 33 (a)
OneToMany
comt-4 36
  • 36 (a)
OneToMany
comt-5 35
  • 47.19 (n)
  • 43.98 (a)
comt-5 36
  • 35 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G61990 35
  • 46.24 (n)
  • 39.22 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.6150 35
rice
(Oryza sativa)
Liliopsida Os08g0154000 35
  • 46.51 (n)
  • 40 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.4917 35
Species with no ortholog for COMTD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for COMTD1 Gene

ENSEMBL:
Gene Tree for COMTD1 (if available)
TreeFam:
Gene Tree for COMTD1 (if available)

Paralogs for COMTD1 Gene

No data available for Paralogs for COMTD1 Gene

Variants for COMTD1 Gene

Sequence variations from dbSNP and Humsavar for COMTD1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs878057 -- 75,236,353(-) CTTCC(C/G)CCTTT upstream-variant-2KB
rs905884 -- 75,236,146(+) GCCCC(G/T)GCGGG upstream-variant-2KB
rs1054321 -- 75,234,127(-) AGGGT(C/T)TACAT reference, synonymous-codon
rs1259505 -- 75,237,183(+) gctta(C/T)tgcag upstream-variant-2KB
rs1259506 -- 75,237,499(+) CTTCT(C/G)CCTCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for COMTD1 Gene

Variant ID Type Subtype PubMed ID
nsv831913 CNV Loss 17160897

Relevant External Links for COMTD1 Gene

HapMap Linkage Disequilibrium report
COMTD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COMTD1 Gene

Disorders for COMTD1 Gene

Relevant External Links for COMTD1

Genetic Association Database (GAD)
COMTD1
Human Genome Epidemiology (HuGE) Navigator
COMTD1
genes like me logo Genes that share disorders with COMTD1: view

No data available for UniProtKB/Swiss-Prot for COMTD1 Gene

Publications for COMTD1 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48

Products for COMTD1 Gene

Sources for COMTD1 Gene

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