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Aliases for COMTD1 Gene

Aliases for COMTD1 Gene

  • Catechol-O-Methyltransferase Domain Containing 1 2 3 5
  • EC 2.1.1.- 4

External Ids for COMTD1 Gene

Previous GeneCards Identifiers for COMTD1 Gene

  • GC10M076339
  • GC10M076663
  • GC10M076993
  • GC10M070992

Summaries for COMTD1 Gene

GeneCards Summary for COMTD1 Gene

COMTD1 (Catechol-O-Methyltransferase Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include O-methyltransferase activity.

UniProtKB/Swiss-Prot for COMTD1 Gene

  • Putative O-methyltransferase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COMTD1 Gene

Genomics for COMTD1 Gene

Regulatory Elements for COMTD1 Gene

Promoters for COMTD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around COMTD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for COMTD1 Gene

75,233,969 bp from pter
75,236,057 bp from pter
2,089 bases
Minus strand

Genomic View for COMTD1 Gene

Genes around COMTD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COMTD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COMTD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COMTD1 Gene

Proteins for COMTD1 Gene

  • Protein details for COMTD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Catechol O-methyltransferase domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • Q8TE79

    Protein attributes for COMTD1 Gene

    262 amino acids
    Molecular mass:
    28809 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for COMTD1 Gene

neXtProt entry for COMTD1 Gene

Proteomics data for COMTD1 Gene at MOPED

Post-translational modifications for COMTD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for COMTD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for COMTD1 Gene

Domains & Families for COMTD1 Gene

Protein Domains for COMTD1 Gene

Suggested Antigen Peptide Sequences for COMTD1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
genes like me logo Genes that share domains with COMTD1: view

No data available for Gene Families for COMTD1 Gene

Function for COMTD1 Gene

Molecular function for COMTD1 Gene

UniProtKB/Swiss-Prot Function:
Putative O-methyltransferase.

Enzyme Numbers (IUBMB) for COMTD1 Gene

genes like me logo Genes that share phenotypes with COMTD1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COMTD1 Gene

Localization for COMTD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COMTD1 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for COMTD1 Gene COMPARTMENTS Subcellular localization image for COMTD1 gene
Compartment Confidence
mitochondrion 3
cytosol 2
extracellular 2
golgi apparatus 2
plasma membrane 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for COMTD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with COMTD1: view

Pathways & Interactions for COMTD1 Gene

SuperPathways for COMTD1 Gene

No Data Available

Interacting Proteins for COMTD1 Gene

Gene Ontology (GO) - Biological Process for COMTD1 Gene


No data available for Pathways by source and SIGNOR curated interactions for COMTD1 Gene

Drugs & Compounds for COMTD1 Gene

(4) Drugs for COMTD1 Gene - From: DrugBank and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tolcapone Approved, Withdrawn Pharma COMT inhibitor 16
Feruloyl Coenzyme A Experimental Pharma Target 0
s-adenosylhomocysteine Experimental Pharma Target 0
Sinapoyl Coenzyme A Experimental Pharma Target 0

(1) ApexBio Compounds for COMTD1 Gene

Compound Action Cas Number
Tolcapone COMT inhibitor 134308-13-7
genes like me logo Genes that share compounds with COMTD1: view

Transcripts for COMTD1 Gene

Unigene Clusters for COMTD1 Gene

Catechol-O-methyltransferase domain containing 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COMTD1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - -
SP2: -
SP3: - - - - - - -
SP4: -

Relevant External Links for COMTD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COMTD1 Gene

mRNA expression in normal human tissues for COMTD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for COMTD1 Gene

This gene is overexpressed in Pancreas (x6.9) and Esophagus - Mucosa (x4.6).

Protein differential expression in normal tissues from HIPED for COMTD1 Gene

This gene is overexpressed in Islet of Langerhans (10.9) and Brain (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for COMTD1 Gene

SOURCE GeneReport for Unigene cluster for COMTD1 Gene Hs.355333

genes like me logo Genes that share expression patterns with COMTD1: view

Protein tissue co-expression partners for COMTD1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for COMTD1 Gene

Orthologs for COMTD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for COMTD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia COMTD1 35
  • 85.5 (n)
  • 88.17 (a)
  • 88 (a)
(Canis familiaris)
Mammalia COMTD1 35
  • 88.55 (n)
  • 87.4 (a)
  • 49 (a)
(Mus musculus)
Mammalia Comtd1 35
  • 84.22 (n)
  • 85.5 (a)
Comtd1 16
Comtd1 36
  • 85 (a)
(Pan troglodytes)
Mammalia COMTD1 35
  • 99.49 (n)
  • 99.62 (a)
  • 56 (a)
(Rattus norvegicus)
Mammalia Comtd1 35
  • 84.35 (n)
  • 86.26 (a)
(Monodelphis domestica)
Mammalia COMTD1 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia COMTD1 36
  • 62 (a)
(Gallus gallus)
Aves COMTD1 35
  • 54.56 (n)
  • 52.14 (a)
  • 51 (a)
(Anolis carolinensis)
Reptilia COMTD1 36
  • 43 (a)
(Danio rerio)
Actinopterygii comtd1 35
  • 55.13 (n)
  • 50.71 (a)
comtd1 36
  • 40 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8831 35
(Caenorhabditis elegans)
Secernentea comt-5 35
  • 47.19 (n)
  • 43.98 (a)
comt-1 36
  • 12 (a)
comt-2 36
  • 37 (a)
comt-3 36
  • 33 (a)
comt-4 36
  • 36 (a)
comt-5 36
  • 35 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G61990 35
  • 46.24 (n)
  • 39.22 (a)
(Hordeum vulgare)
Liliopsida Hv.6150 35
(Oryza sativa)
Liliopsida Os08g0154000 35
  • 46.51 (n)
  • 40 (a)
(Triticum aestivum)
Liliopsida Ta.4917 35
Species with no ortholog for COMTD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for COMTD1 Gene

Gene Tree for COMTD1 (if available)
Gene Tree for COMTD1 (if available)

Paralogs for COMTD1 Gene

No data available for Paralogs for COMTD1 Gene

Variants for COMTD1 Gene

Sequence variations from dbSNP and Humsavar for COMTD1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs905884 -- 75,236,146(+) GCCCC(G/T)GCGGG upstream-variant-2KB
rs1054321 -- 75,234,127(-) AGGGT(C/T)TACAT reference, synonymous-codon
rs1259505 -- 75,237,183(+) gctta(C/T)tgcag upstream-variant-2KB
rs1259506 -- 75,237,499(+) CTTCT(C/G)CCTCT upstream-variant-2KB
rs1259507 -- 75,237,511(+) TGAAA(A/T)GGCGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for COMTD1 Gene

Variant ID Type Subtype PubMed ID
nsv831913 CNV Loss 17160897

Variation tolerance for COMTD1 Gene

Gene Damage Index Score: 2.13; 38.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COMTD1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COMTD1 Gene

Disorders for COMTD1 Gene

Relevant External Links for COMTD1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for COMTD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COMTD1 Gene

Publications for COMTD1 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Genetic variants associated with breast size also influence breast cancer risk. (PMID: 22747683) Eriksson N. … Tung J.Y. (BMC Med. Genet. 2012) 3
  5. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 3

Products for COMTD1 Gene

Sources for COMTD1 Gene

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