V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

COMT Gene

protein-coding GIFtS: 72

GC22P018303

catechol-O-methyltransferase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.1.1.6 ^³
catechol-O-methyltransferase ^²

External Ids
HGNC: 2228¹
Entrez Gene: 1312²
UniProtKB: P21964³
Ensembl: ENSG00000093010⁷

Search outside databases for aliases for COMT gene

Previous GC identifer: GC22P016869

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for COMT:

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to

catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This

O-methylation results in one of the major degradative pathways of the catecholamine transmitters.

In addition to its role in the metabolism of endogenous substances, COMT is important in the

metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease.

COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form

(MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several

transcript variants are formed through the use of alternative translation initiation sites and

promoters. [provided by RefSeq]

UniProtKB/Swiss-Prot: COMT_HUMAN, P21964

Function: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine

neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain

neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol

Gene Wiki entry for COMT (Catechol-O-methyl_transferase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the COMT gene

Entrez Gene cytogenetic band: 22q11.21-q11.23|22q11.21 Ensembl cytogenetic band: 22q11.21 HGNC cytogenetic band: 22q11.21

COMT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22P018303: (about GC identifiers)

Start:	18,309,256 bp from pter
End:	18,336,539 bp from pter
Size:	27,284 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000022.9 NT_011519.10

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: COMT_HUMAN, P21964 (See protein sequence)

Recommended Name: Catechol O-methyltransferase

Size: 271 amino acids; 30037 Da

Cofactor: Binds 1 magnesium ion per subunit

Subcellular location: Isoform Soluble: Cytoplasm

Subcellular location: Isoform Membrane-bound: Cell membrane; Single-pass type II membrane protein;

Extracellular side

Mass spectrometry: Mass=24352; Mass_error=2; Method=Electrospray; Range=52-271;

Source=PubMed:8020475;

PDB structure from and Proteopedia :

3BWM (3D)

3BWY (3D)

Secondary accessions: Q6IB07 Q6ICE6

Alternative initiation: 2 isoforms: P21964-1 P21964-2

Post-translational modifications:

The N-terminus is blocked¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_000745.1 NP_001128633.1 NP_001128634.1 NP_009294.1

ENSEMBL proteins:

ENSP00000383966 ENSP00000385150 ENSP00000385917 ENSP00000384654 ENSP00000207636 ENSP00000385831

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (COMT)
	Human Recombinant Proteins from Abnova (COMT)

OriGene Purified Recombinant Human Protein: COMT

5/7 Gene Ontology (GO) cellular component terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005625	soluble fraction	TAS	1707278
GO:0005737	cytoplasm	IEA	--
GO:0005792	microsome	TAS	1707278
GO:0005829	cytosol	EXP	8968737
GO:0005886	plasma membrane	IEA	--

About this table

Antibodies for COMT:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of COMT
	Sigma-Aldrich Antibodies for COMT
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (COMT), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (COMT)
	Novus Biologicals Antibodies for COMT

Assays for COMT:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P21964

ProtoNet protein and cluster: P21964

1 Blocks protein family: IPB002935 O-methyltransferase

UniProtKB/Swiss-Prot: COMT_HUMAN, P21964

Similarity: Belongs to the mammalian catechol-O-methyltransferase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (COMT)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (COMT)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_001135162

Applied Biosystems Silencer® siRNAs for COMT

Sigma-Aldrich siRNA and siRNA Panels for COMT

Sigma-Aldrich shRNA for COMT

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for COMT
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_000754
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_000754
untagged cDNA clones in CMV expression vector (see all 5): NM_000754

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000754

UniProtKB/Swiss-Prot: COMT_HUMAN, P21964

Function: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine

neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain

neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol

Catalytic activity: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol

Enzyme Number (IUBMB): EC 2.1.1.6

Genatlas biochemistry entry for COMT:

catechol-O-methyltransferase,with CAG repeat,degrading the catecholamine and inactivating catechol

drugs in the central nervous system,putative minor contributor to schizophrenia susceptibility in

a French series,but potential risk factor for homicidal behavior in schizophrenia and potential

risk factor of high activity Val allele in attention deficit hyperactivity disorder

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Comt1):

behavior/neurological

nervous system

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000287	magnesium ion binding	IEA	--
GO:0005515	protein binding	IPI	15231747
GO:0016206	catechol O-methyltransferase activity	IEA	--
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for COMT (Your Favorite Gene powered by Ingenuity)

Tyrosine Metabolism
Dopamine Receptor Signaling

GeneDecks COMT for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for COMT

5/77 Interacting proteins for COMT (P21964^{1, 2} ENSP00000207636³) via UniProtKB, MINT, and/or STRING (see all 77 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
XRN2	Q9H0D6¹	EBI-372265, EBI-372110
LITAF	Q99732²	MINT-65288
TRIP13	Q15645²	MINT-66331
MAOA	ENSP00000340684³	STRING (score=.991)
DRD2	ENSP00000347474³	STRING (score=.985)

About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006584	catecholamine metabolic process	IEA	--
GO:0042135	neurotransmitter catabolic process	IEA	--
GO:0042420	dopamine catabolic process	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for COMT

Sigma-Aldrich Small Molecules for COMT:

Inhibitor

Compounds for COMT available from Tocris Bioscience

Compound	Action	CAS number
OR-486	Catechol-O-methyl transferase inhibitor	[7659-29-2]

About this table

10/44 Novoseek chemical compound relationships for COMT gene (see all 44 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
3-o-methyldopa	91.33	33	8527287 (3), 9333106 (2), 11290879 (2), 9808337 (1) (see all 20)
or486	81.00	9	15507517 (2), 11882582 (2), 18486144 (1), 17560937 (1) (see all 7)
5-hydroxyconiferyl alcohol	78.60	1	11423146 (1)
4-hydroxyestradiol	76.38	7	11706521 (1), 19020775 (1), 19077667 (1), 15100171 (1) (see all 6)
2-hydroxyestradiol	73.33	8	11701460 (2), 11706521 (1), 19020775 (1), 11882582 (1) (see all 7)
stalevo	68.54	1	18975095 (1)
catecholamine	68.21	68	11502905 (4), 12959293 (3), 7874370 (2), 8612391 (2) (see all 51)
3-methoxytyramine	66.56	8	7834959 (1), 15354384 (1), 8283823 (1), 9661138 (1) (see all 5)
s-adenosylmethionine	64.56	42	11577006 (3), 10755376 (2), 11520127 (2), 2128841 (2) (see all 22)
homovanillic acid	61.93	14	12741370 (3), 9147493 (2), 9477008 (1), 12957500 (1) (see all 7)

About this table

8 PharmGKB drug compound relationships for COMT gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
3,4-methylenedioxymethamphetamine	PK	15228154
folic acid	PD GN	14656021
levodopa	PK	12898345
methyldopa	PD PK	7398195
modafinil	PD	11990384
sparteine	CO	11773866
vitamin b12	PD GN	14656021
xenobiotics	CO PD	9259381

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (COMT)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (COMT)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_001135162

Sigma-Aldrich siRNA and siRNA Panels for COMT

Sigma-Aldrich shRNA for COMT

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000754 NM_001135161 NM_001135162 NM_007310

REFSEQ mRNAs for COMT gene (4 alternative transcripts):

NM_000754.3 NM_001135161.1 NM_001135162.1 NM_007310.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000754 NM_001135161 NM_001135162 NM_007310

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_000754
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_000754
                                 untagged cDNA clones in CMV expression vector (see all 5): NM_000754

Additional cDNA sequence:

AK092664.1 AL390148.1 BC005092.1 BC036893.1 BC137436.1 CR590273.1 CR623754.1 EF217321.1

EF217322.1 M65213.1 U51269.1 U84509.1

24/45 DOTS entries (see all 45 ):

DT.100053173 DT.91707484 DT.100720599 DT.91985741 DT.100668744 DT.100824734 DT.100668740 DT.445233

DT.91827051 DT.100824740 DT.100778546 DT.87024869 DT.92067937 DT.92473588 DT.91893551 DT.70102245

DT.100738288 DT.95279862 DT.97769223 DT.100027592 DT.91812748 DT.97860453 DT.120644670 DT.120644691

24/855 AceView cDNA sequences (see all 855 ):

CA842397 CR603785 CR610886 BF724444 AW768435 CF528521 CR625831 Z41079

AA447648 BG056774 AU279590 BQ682461 NM_007310 BX338317 BQ073544 BE349135

CR613786 BQ448204 BE385974 CR624969 BG054676 BF724613 F02815 CR610047

highest scoring ESTs for COMT:

M58525 AA025282 AA092663 AA093705 AA093720 AA131404 AA131504 AA303869 AA341286 AA357690

Unigene Clusters for COMT:

Catechol-O-methyltransferase

Hs.370408 [show with all ESTs], Hs.704514 [show with all ESTs], Hs.713616 [show with all ESTs]

Unigene Representative Sequences: NM_000754, BX449536, NM_001670

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for COMT (see all 8 )

ExUns:	1	^	2	^	3a	·	3b	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	·	7c	^	8a	·	8b	^	9	^	10a	·	10b
SP1:											-		-		-		-		-		-						-				-
SP2:																															-
SP3:																											-				-
SP4:					-		-						-
SP5:													-

About this scheme

ECgene alternative splicing isoforms for COMT

6 Ensembl transcripts including schematic representations:

ENST00000403184 ENST00000406520 ENST00000403710 ENST00000407537 ENST00000207636 ENST00000402871

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

COMT expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for COMT

¹ / ² / ³

8 probe-sets matching COMT gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
34651_at²^{, 3}	U95-A	1	1.00	1.00	0.36	1.16	M58525	1.00	1.00	1.00	1
68511_at*²^{, 3}	U95-E	1	0.50	1.00	0.48	0.85	AI380389	0.20	1.00	0.72	1
213981_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BG054676	0.80	1.00	0.91	1
208818_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC000419	0.80	1.00	0.91	1
208817_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC000419	0.80	1.00	0.91	1
213981_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208818_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208817_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks COMT for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene clusters: Hs.370408 Hs.704514 Hs.713616
Expression variation in blood from EXPOLDB for COMT
UniProtKB/Swiss-Prot: COMT_HUMAN, P21964
Tissue specificity: Brain, liver, placenta, lymphocytes and erythrocytes

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for COMT gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	COMT¹	--	catechol-O-methyltransferase	83.71(n) 80.54(a)	445450 NM_001004074.1 NP_001004074.1
chimpanzee (Pan troglodytes)	COMT¹	--	catechol-O-methyltransferase	99.14(n) 99.26(a)	458655 XM_514984.2 XP_514984.2
cow (Bos taurus)	COMT¹	--	catechol-O-methyltransferase	80.93(n) 73.43(a)	618278 XM_870610.2 XP_875703.2
rat (Rattus norvegicus)	Comt¹	--	catechol-O-methyltransferase	78.81(n) 79.46(a)	24267 NM_012531.1 NP_036663.1
mouse (Mus musculus)	Comt1^{1, 5}	16 (11.20 cM)⁵	catechol-O-methyltransferase 1^{1, 5}	78.85(n)¹ 80(a)¹	12846¹ NM_007744.2¹ NP_031770.1¹ AA407643⁵ AA637157⁵ (see all 18)

About this table Species with no ortholog for COMT

ENSEMBL Gene Tree for COMT

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: COMT_HUMAN, P21964

Polymorphism: Two alleles, COMT*1 or COMT*H with Val-158 and COMT*2 or COMT*L with Met-158 are

responsible for a three to four-fold difference in enzymatic activity

Polymorphism: Low enzyme activity alleles are associated with genetic susceptibility to alcoholism

[MIM:103780]

10/314 NCBI SNPs in COMT are shown (see all 314 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 132)

AB	SNP ID	Valid	Chr 22 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs739368^1,2	A,C,F,H,O	18319096(-)	`ACCCTC/TGGATG`	2	--	ut5¹ int¹		9	NA MN EU EA WA	826
	rs4646312^1,2	A,C,F,H	18328337(+)	`TAAACT/CAGCCC`	2	--	int¹ ng5¹		28	NS EU EA WA NA MN CSAM	2656
	rs4680^1,2	A,C,F,H	18331271(+)	`CTGGCA/GTGAAG`	4	V/M	mis¹		33	NA EA MN CSAM EU NS WA	4462
	rs6269^1,2	A,C,F,O	18329952(+)	`TCTGCA/GAACAC`	2	--	ng5¹ int¹		6	MN NA EA	672
	rs165656^1,2	A,C,F,H	18328863(+)	`ATTCCG/CGCCCG`	2	--	ng5¹ int¹		13	EA NS MN CSAM	2836
	rs3810595^1,2	A,C,F	18329644(-)	`GTAGTC/GACGGG`	2	--	int¹ ng5¹		6	NS MN CSAM EA	530
	rs9332380^1,2	C,F,H	18336417(+)	`GAACTG/ACAACA`	4	--	ut3¹ ese³		11	NS EU EA WA MN CSAM	1116
	rs6270^1,2	C,F,H	18330150(+)	`CCTGTG/CCCTTA`	4	S/C	mis¹ ut5¹ ese³		11	MN CSAM EA EU WA	1076
--	rs11569715^1,2	C,F,H	18328742(+)	`TGCTGC/GCGAGC`	4	--	ut5¹ ng5¹ ese³		10	MN CSAM EA EU WA	1064
	rs165599^1,2	A,C,F	18336781(+)	`CTGCCA/GGCCTG`	4	--	ut3¹ ese³		1	EA	180

About this table

HapMap Linkage Disequilibrium images for COMT (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 116790 disorders: 181500 167870

10/90 Novoseek disease relationships for COMT gene (see all 90 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
parkinson disease	82.73	157	9808337 (3), 10895397 (3), 15495118 (3), 11170218 (2) (see all 99)
schizophrenia	79.61	444	17412710 (8), 12802784 (6), 19329282 (6), 16109444 (6) (see all 99)
velo-cardio-facial syndrome	76.18	9	10490696 (1), 15645182 (1), 8950408 (1), 16511839 (1) (see all 9)
attention-deficit hyperactivity disorder	66.12	16	19228412 (2), 17075359 (2), 10898901 (1), 17949513 (1) (see all 14)
velocardiofacial syndrome	65.98	9	10450274 (2), 12192614 (1), 15505638 (1), 12802784 (1) (see all 7)
bipolar disorder	63.67	49	15211633 (4), 17948281 (3), 9330018 (2), 8988970 (2) (see all 29)
polysubstance abuse	58.70	1	11054766 (1)
obsessive-compulsive disorder	55.95	14	11840516 (2), 17264842 (2), 10331110 (1), 12900951 (1) (see all 12)
schizotypal personality	50.97	2	17034018 (1), 17604122 (1)
psychiatric disorder	50.73	38	17419009 (4), 16780746 (2), 15572182 (2), 17949513 (2) (see all 27)

About this table

6 PharmGKB disease relationships for COMT gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Breast Neoplasms	CO	11773866
Hyperhomocysteinemia	PD GN	14656021
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872
Narcolepsy	PD	11990384
Parkinson Disease	PD PK FA GN	7398195 12898345 14966473
Substance-Related Disorders	CO PD	9259381

About this table

Human Gene Mutation Database: COMT
Genetic Association Database: COMT
Human Genome Epidemiology Navigator: COMT (636 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1149 PubMed articles for COMT gene (see all 1149 ):

The role of genetic factors in the development of hyperhomocysteinemia. (PubMed id 14656021)^{1, 3, 6, 7} Geisel J....Herrmann W. (2003)
Sexual dimorphism of the catechol-O-methyltransferase gene in narcolepsy is associated with response to modafinil. (PubMed id 11990384)^{1, 3, 7} Dauvilliers Y....Tafti M. (2002)
Combined COMT and GST genotypes and hormone replacement therapy associated breast cancer risk. (PubMed id 11773866)^{1, 3, 7} Mitrunen K....Hirvonen A. (2002)
Analysis of an association between the COMT polymorphism and clinical symptomatology in schizophrenia. (PubMed id 16233957)^{1, 3, 6} Strous R.D....Lachman H.M. (2006)
Cytochrome P450 1B1 and catechol-O-methyltransferase genetic polymorphisms and breast cancer risk in Chinese women: results from the shanghai breast cancer study and a meta-analysis. (PubMed id 15734954)^{1, 3, 6} Wen W....Zheng W. (2005)
The effect of monoamine oxidase B (MAOB) and catechol-O-methyltransferase (COMT) polymorphisms on levodopa therapy in patients with sporadic Parkinson's disease. (PubMed id 15355491)^{1, 3, 6} Bial/ecka M....Stankiewicz J. (2004)
Association analysis of MAOA and COMT with neuroticism assessed by peers. (PubMed id 12815746)^{1, 3, 6} Eley T.C....Craig I. (2003)
Catechol-O-methyltransferase gene polymorphism in schizophrenia: evidence for association between symptomatology and prognosis. (PubMed id 11525417)^{1, 3, 6} Herken H. and Erdal M.E. (2001)
Catechol-O-methyltransferase polymorphism is not associated with ovarian cancer risk. (PubMed id 11142424)^{1, 3, 6} Goodman J.E....Yager J.D. (2000)
Gene-gene interaction between MAOA and COMT in suicidal behavior. (PubMed id 15936529)^{1, 3, 6} De Luca V....Kennedy J.L. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1312	HGNC: 2228	AceView: COMT	Ensembl:ENSG00000093010	euGenes: HUgn1312
ECgene: COMT	H-InvDB: COMT

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for COMT	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/comt/
Wikipedia	http://en.wikipedia.org/wiki/Catechol-O-methyl_transferase

Licensable Technologies for COMT
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for COMT:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for COMT-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for COMT		Antibodies for COMT
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for COMT		Small molecules for COMT
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (COMT)
	Antibodies (COMT)
	Chimera RNAi (COMT)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (COMT)
	Antibodies (COMT)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Tocris compounds for COMT

	Drugs for COMT
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for COMT

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
COMT Gene at Home site.
Version 2.41.1
server4.xennexinc.com

COMT Gene

protein-coding GIFtS: 72

Aliases &
Descriptions
for COMT

Summaries
for COMT

Genomic Location
for COMT

Proteins
for COMT

Protein Domains/
Families
for COMT

Gene Function
for COMT

Pathways & Interactions
for COMT

Drugs & Compounds
for COMT

Transcripts
for COMT

Expression
for COMT

Orthologs
for COMT

Paralogs
for COMT

SNPs/Variants
for COMT

Disorders & Mutations
for COMT

Medical News
for COMT

Publications
for COMT

Search for COMT

Genome Databases showing COMT

Other Databases showing COMT

Specialized Databases showing COMT

Licensable Technologies
for COMT

Services
for COMT

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

COMT Gene

protein-coding GIFtS: 72

Aliases & Descriptionsfor COMT

Summariesfor COMT

Genomic Locationfor COMT

Proteinsfor COMT

Protein Domains/Familiesfor COMT

Gene Functionfor COMT

Pathways & Interactionsfor COMT

Drugs & Compoundsfor COMT

Transcriptsfor COMT

Expression for COMT

Orthologsfor COMT

Paralogsfor COMT

SNPs/Variantsfor COMT

Disorders & Mutationsfor COMT

Medical Newsfor COMT

Publicationsfor COMT

Search for COMT

Genome Databases showing COMT

Other Databases showing COMT

Specialized Databases showing COMT

Licensable Technologiesfor COMT

Servicesfor COMT

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for COMT

Summaries
for COMT

Genomic Location
for COMT

Proteins
for COMT

Protein Domains/
Families
for COMT

Gene Function
for COMT

Pathways & Interactions
for COMT

Drugs & Compounds
for COMT

Transcripts
for COMT

Expression
for COMT

Orthologs
for COMT

Paralogs
for COMT

SNPs/Variants
for COMT

Disorders & Mutations
for COMT

Medical News
for COMT

Publications
for COMT

Licensable Technologies
for COMT

Services
for COMT