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Aliases for COMT Gene

Aliases for COMT Gene

  • Catechol-O-Methyltransferase 2 3
  • EC 2.1.1.6 4 63
  • Epididymis Secretory Sperm Binding Protein Li 98n 3
  • Catechol O-Methyltransferase 3
  • HEL-S-98n 3

External Ids for COMT Gene

Previous GeneCards Identifiers for COMT Gene

  • GC22P016869
  • GC22P018303
  • GC22P019929
  • GC22P003549

Summaries for COMT Gene

Entrez Gene Summary for COMT Gene

  • Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]

GeneCards Summary for COMT Gene

COMT (Catechol-O-Methyltransferase) is a Protein Coding gene. Diseases associated with COMT include panic disorder and cisplatin toxicity. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include magnesium ion binding and catechol O-methyltransferase activity. An important paralog of this gene is LRTOMT.

UniProtKB/Swiss-Prot for COMT Gene

  • Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol

Tocris Summary for COMT Gene

  • Catechol-O-methyltransferase (COMT) is involved in metabolism of catecholamines (dopamine, adrenalin and noradrenalin). COMT is localized to postsynaptic neurons where it degrades neurotransmitters following their release.

Gene Wiki entry for COMT Gene

PharmGKB "VIP" Summary for COMT Gene

No data available for fRNAdb sequence ontologies and piRNA Summary for COMT Gene

Genomics for COMT Gene

Regulatory Elements for COMT Gene

Genomic Location for COMT Gene

Start:
19,941,607 bp from pter
End:
19,969,975 bp from pter
Size:
28,369 bases
Orientation:
Plus strand

Genomic View for COMT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COMT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COMT Gene

Proteins for COMT Gene

  • Protein details for COMT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21964-COMT_HUMAN
    Recommended name:
    Catechol O-methyltransferase
    Protein Accession:
    P21964
    Secondary Accessions:
    • A8MPV9
    • Q6IB07
    • Q6ICE6
    • Q9BWC7

    Protein attributes for COMT Gene

    Size:
    271 amino acids
    Molecular mass:
    30037 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH00419.2; Type=Erroneous termination; Positions=85; Note=Translated as Gln.; Evidence={ECO:0000305}; Sequence=AAH05867.1; Type=Erroneous termination; Positions=85; Note=Translated as Gln.; Evidence={ECO:0000305}; Sequence=ACI46037.1; Type=Erroneous termination; Positions=85; Note=Translated as Gln.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for COMT Gene

    Alternative splice isoforms for COMT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COMT Gene

Proteomics data for COMT Gene at MOPED

Selected DME Specific Peptides for COMT Gene

Post-translational modifications for COMT Gene

Domains for COMT Gene

Protein Domains for COMT Gene

Graphical View of Domain Structure for InterPro Entry

P21964

UniProtKB/Swiss-Prot:

COMT_HUMAN :
  • P21964
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
genes like me logo Genes that share domains with COMT: view

No data available for Gene Families for COMT Gene

Function for COMT Gene

Molecular function for COMT Gene

GENATLAS Biochemistry: catechol-O-methyltransferase,with CAG repeat,degrading the catecholamine and inactivating catechol drugs in the central nervous system,putative minor contributor to schizophrenia susceptibility in a French series,but potential risk factor for homicidal behavior in schizophrenia and potential risk factor of high activity Val allele in attention deficit hyperactivity disorder
UniProtKB/Swiss-Prot CatalyticActivity: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol
UniProtKB/Swiss-Prot Function: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol

Enzyme Numbers (IUBMB) for COMT Gene

Gene Ontology (GO) - Molecular Function for COMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0008171 O-methyltransferase activity TAS 1707278
GO:0016206 catechol O-methyltransferase activity IEA --
genes like me logo Genes that share ontologies with COMT: view
genes like me logo Genes that share phenotypes with COMT: view

Animal Models for COMT Gene

MGI Knock Outs for COMT:

miRNA for COMT Gene

miRTarBase miRNAs that target COMT

No data available for Transcription Factor Targeting and HOMER Transcription for COMT Gene

Localization for COMT Gene

Subcellular locations from UniProtKB/Swiss-Prot for COMT Gene

Isoform Soluble: Cytoplasm.
Isoform Membrane-bound: Cell membrane; Single-pass type II membrane protein; Extracellular side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COMT Gene COMPARTMENTS Subcellular localization image for COMT gene
Compartment Confidence
plasma membrane 5
cytosol 4
extracellular 3
mitochondrion 2
nucleus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for COMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with COMT: view

Pathways for COMT Gene

genes like me logo Genes that share pathways with COMT: view

Gene Ontology (GO) - Biological Process for COMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006584 catecholamine metabolic process --
GO:0006805 xenobiotic metabolic process TAS --
GO:0007268 synaptic transmission TAS --
GO:0007565 female pregnancy IEA --
GO:0007612 learning IEA --
genes like me logo Genes that share ontologies with COMT: view

Compounds for COMT Gene

(15) ApexBio Compounds for COMT Gene

Compound Action Cas Number
3-Deazaneplanocin,DZNep Blocks EZH2 activity and trimethylation of lysine 27 on histone H3 in vitro. [102052-95-9]
AZ505 potent and highly selective inhibitor of the oncogenic protein SMYD2. [1035227-43-0]
BIX 01294 BIX-01294 is a small molecule inhibitor of G9a and GLP. [935693-62-2]
Chaetocin Histone methyltransferase SUV39H1 inhibitor [28097-03-2]
Entacapone Entacapone inhibits catechol-O-methyltransferase(COMT) [130929-57-6]
EPZ004777 potent, selective DOT1L inhibitor [1338466-77-5]
EPZ005687 potent inhibitor of EZH2 [1396772-26-1]
EPZ5676 potent inhibitor of DOT1L histone methyltransferase [1380288-87-8]
EPZ-6438 potent and bio-available inhibitor of EZH2 [1403254-99-8 ]
SGC 0946 highly potent and selective DOT1 Lmethyltransferase inhibitor
UNC 0224 Potent inhibitor of G9a histone lysine methyltransferase [1197196-48-7]
UNC 0631 potent G9a inhibitor [1320288-19-4]
UNC 0646 Potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP [1320288-17-2]
UNC0321 potent and selective G9a inhibitor [1238673-32-9]
UNC0638 Selective inhibitor of G9a and GLP histone lysine methyltransferases (IC50 values are < 15 nM and 19 nM for G9a and GLP respectively, and > 10000 nM for a range of other histone methyltransferases). [1255580-76-7]

(2) Tocris Compounds for COMT Gene

Compound Action Cas Number
Entacapone Potent COMT inhibitor; blocks alpha-synuclein aggregation [130929-57-6]
OR-486 Catechol O-methyltransferase inhibitor [7659-29-2]

(26) HMDB Compounds for COMT Gene

Compound Synonyms Cas Number PubMed IDs
(-)-Salsoline
  • (1S)-7-methoxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-6-ol
89-31-6
2-Hydroxyestradiol-3-methyl ether
  • (17b)-3-methoxy-Estra-1,3,5(10)-triene-2,17-diol
5976-65-8
2-Methoxyestrone
  • 2-(8S,9S,13S,14S)-3-hydroxy-2-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one
362-08-3
3,4-Dihydroxybenzeneacetic acid
  • (3,4-Dihydroxyphenyl)acetate
102-32-9
3,4-Dihydroxymandelic acid
  • 3,4 Dihydroxymandelate
775-01-9

(17) Drugbank Compounds for COMT Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
(3,4-DIHYDROXY-2-NITROPHENYL)(PHENYL)METHANONE
target
3,5-Dinitrocatechol
target
7,8-dihydroxy-4-phenyl-2H-chromen-2-one
target
BIA
target
Conjugated Estrogens
  • Estrogens
438-67-5 enzyme substrate

(108) Novoseek inferred chemical compound relationships for COMT Gene

Compound -log(P) Hits PubMed IDs
entacapone 96.2 144
tolcapone 95.8 136
3-o-methyldopa 91.2 29
levodopa 89.1 220
dopamine 85.4 155

(9) PharmGKB related drug/compound annotations for COMT Gene

Drug/compound Annotation
antipsychotics CA
bupropion CA
cisplatin CA
fluvoxamine CA
morphine CA
nicotine CA
opioids CA
risperidone CA
venlafaxine CA
genes like me logo Genes that share compounds with COMT: view

Transcripts for COMT Gene

Unigene Clusters for COMT Gene

Catechol-O-methyltransferase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COMT Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b
SP1: - - - - - - - -
SP2: -
SP3: - -
SP4: - - -
SP5: -
SP6: -
SP7: - - - -
SP8: - - -

Relevant External Links for COMT Gene

GeneLoc Exon Structure for
COMT
ECgene alternative splicing isoforms for
COMT

Expression for COMT Gene

mRNA expression in normal human tissues for COMT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COMT Gene

SOURCE GeneReport for Unigene cluster for COMT Gene Hs.370408

mRNA Expression by UniProt/SwissProt for COMT Gene

P21964-COMT_HUMAN
Tissue specificity: Brain, liver, placenta, lymphocytes and erythrocytes
genes like me logo Genes that share expressions with COMT: view

No data available for mRNA differential expression in normal tissues for COMT Gene

Orthologs for COMT Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for COMT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COMT 35
  • 99.14 (n)
  • 99.26 (a)
COMT 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia COMT 35
  • 80.81 (n)
  • 73.06 (a)
COMT 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COMT 35
  • 83.71 (n)
  • 80.54 (a)
COMT 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Comt 35
  • 79.75 (n)
  • 80.58 (a)
Comt 16
Comt 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia COMT 36
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COMT 36
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Comt 35
  • 79.81 (n)
  • 79.25 (a)
chicken
(Gallus gallus)
Aves COMT 35
  • 63.81 (n)
  • 59.66 (a)
COMT 36
  • 56 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15713 35
tropical clawed frog
(Silurana tropicalis)
Amphibia comt 35
  • 63.65 (n)
  • 59.73 (a)
zebrafish
(Danio rerio)
Actinopterygii comta 36
  • 48 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU07919 35
  • 48.17 (n)
  • 40.85 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC119.03 35
  • 51.53 (n)
  • 40.54 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToOne
Species with no ortholog for COMT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COMT Gene

ENSEMBL:
Gene Tree for COMT (if available)
TreeFam:
Gene Tree for COMT (if available)

Paralogs for COMT Gene

Paralogs for COMT Gene

genes like me logo Genes that share paralogs with COMT: view

Variants for COMT Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for COMT Gene

P21964-COMT_HUMAN
Low enzyme activity alleles are associated with genetic susceptibility to alcoholism [MIM:103780]

Sequence variations from dbSNP and Humsavar for COMT Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs165656 -- 19,961,340(+) ATTCC(C/G)GCCCG intron-variant, upstream-variant-2KB
rs165722 -- 19,961,490(+) CTGTC(C/T)TCTGG intron-variant, upstream-variant-2KB
rs165737 -- 19,964,978(+) GCCTC(C/T)CCACC intron-variant
rs165767 -- 19,957,037(+) gctcc(A/G)cctct intron-variant
rs165774 -- 19,965,038(+) CAGCC(A/G)GACTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COMT Gene

Variant ID Type Subtype PubMed ID
nsv435744 CNV Deletion 17901297
nsv914263 CNV Gain 21882294
nsv914279 CNV Loss 21882294
nsv828938 CNV Gain 20364138
nsv828939 CNV Loss 20364138
nsv469641 CNV Loss 16826518
dgv72n68 CNV Loss 17160897
nsv914306 CNV Loss 21882294
nsv914307 CNV Loss 21882294
dgv4848n71 CNV Loss 21882294
dgv4849n71 CNV Loss 21882294
dgv4850n71 CNV Loss 21882294
esv2723991 CNV Deletion 23290073
esv1007918 CNV Deletion 20482838
esv1009031 CNV Deletion 20482838
esv1291604 CNV Deletion 17803354
dgv4851n71 CNV Loss 21882294
nsv517165 CNV Loss 19592680
dgv4852n71 CNV Loss 21882294

Relevant External Links for COMT Gene

HapMap Linkage Disequilibrium report
COMT
Human Gene Mutation Database (HGMD)
COMT

Disorders for COMT Gene

(2) OMIM Diseases for COMT Gene (116790)

(93) Novoseek inferred disease relationships for COMT Gene

Disease -log(P) Hits PubMed IDs
parkinson disease 82.1 122
schizophrenia 79.6 292
velo-cardio-facial syndrome 76.8 9
attention-deficit hyperactivity disorder 65.7 19
bipolar disorder 64.7 49

Relevant External Links for COMT

Genetic Association Database (GAD)
COMT
Human Genome Epidemiology (HuGE) Navigator
COMT
genes like me logo Genes that share disorders with COMT: view

No data available for UniProtKB/Swiss-Prot for COMT Gene

Publications for COMT Gene

  1. Association of Ala72Ser polymorphism with COMT enzyme activity and the risk of schizophrenia in Koreans. (PMID: 15645182) Lee S.-G. … Song K. (Hum. Genet. 2005) 3 4 23 48
  2. Catechol O-methyltransferase val158-met polymorphism is associated with abdominal obesity and blood pressure in men. (PMID: 18442637) Annerbrink K. … Eriksson E. (Metabolism 2008) 3 4 23 48
  3. Crystal structures of human 108V and 108M catechol O- methyltransferase. (PMID: 18486144) Rutherford K. … Parson W.W. (J. Mol. Biol. 2008) 3 4 23 25
  4. Synergistic effects of the dopaminergic and glutamatergic system on hippocampal volume in alcohol-dependent patients. (PMID: 18423838) Puls I. … Heinz A. (Biol Psychol 2008) 3 23 48
  5. Val158Met polymorphism in the catechol-O-methyltransferase (COMT) gene is not associated with tardive dyskinesia in schizophrenia. (PMID: 18424907) Kang S.G. … Kim L. (Neuropsychobiology 2008) 3 23 48

Products for COMT Gene

Sources for COMT Gene

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