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Aliases for COMP Gene

Aliases for COMP Gene

  • Cartilage Oligomeric Matrix Protein 2 3 5
  • Thrombospondin-5 2 3 4
  • Cartilage Oligomeric Matrix Protein (Pseudoachondroplasia, Epiphyseal Dysplasia 1, Multiple) 2 3
  • TSP5 3 4
  • Pseudoachondroplasia (Epiphyseal Dysplasia 1, Multiple) 3
  • THBS5 3
  • PSACH 3
  • EDM1 3
  • EPD1 3
  • MED 3

External Ids for COMP Gene

Previous HGNC Symbols for COMP Gene

  • PSACH
  • EDM1
  • EPD1

Previous GeneCards Identifiers for COMP Gene

  • GC19M019387
  • GC19M019285
  • GC19M018738
  • GC19M018894
  • GC19M018458

Summaries for COMP Gene

Entrez Gene Summary for COMP Gene

  • The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Contraction or expansion of a 5 aa aspartate repeat and other mutations can cause pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). [provided by RefSeq, Jul 2016]

GeneCards Summary for COMP Gene

COMP (Cartilage Oligomeric Matrix Protein) is a Protein Coding gene. Diseases associated with COMP include Pseudoachondroplasia and Epiphyseal Dysplasia, Multiple, 1. Among its related pathways are Focal Adhesion and Degradation of the extracellular matrix. GO annotations related to this gene include calcium ion binding and protease binding. An important paralog of this gene is THBS4.

UniProtKB/Swiss-Prot for COMP Gene

  • May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity).

Gene Wiki entry for COMP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COMP Gene

Genomics for COMP Gene

Regulatory Elements for COMP Gene

Enhancers for COMP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G018846 1.4 Ensembl ENCODE dbSUPER 12.4 -57.4 -57447 5.2 CBX3 TBL1XR1 SIN3A ARID4B ZNF2 RAD21 EGR1 ZNF143 ETV6 IKZF2 COMP C19orf60 ENSG00000269694 LOC102724360 PIR45819 GC19P019312 UPF1
GH19G018761 1.7 FANTOM5 Ensembl ENCODE dbSUPER 9.9 +27.8 27764 4.1 PKNOX1 AGO1 SIN3A FEZF1 ZNF121 GATA2 FOS SP5 ZHX2 JUNB COMP CRLF1 TMEM59L HAPLN4 KXD1 GC19P019540 GC19M018784
GH19G018839 1.2 ENCODE dbSUPER 11.8 -48.8 -48761 1.6 HDGF MLX ZFP64 ARID4B DMAP1 ZNF48 SLC30A9 ZNF143 FOS SP5 COMP C19orf60 LOC102724360 UPF1 PIR45819 GC19P019312
GH19G018838 1.1 ENCODE dbSUPER 11.8 -47.7 -47703 0.2 HDGF PKNOX1 TBL1XR1 ZMYM3 EBF1 RELA ARID3A NFYB EED ZNF143 COMP C19orf60 UPF1 PIR45819 GC19P019312
GH19G018019 2.1 FANTOM5 Ensembl ENCODE dbSUPER 6.1 +768.7 768717 5.6 HDGF HNRNPUL1 PKNOX1 CREB3L1 MLX ARNT SIN3A ARID4B DMAP1 YY1 ARRDC2 IFI30 LOC440514 COMP UBA52 LRRC25 JUND FCHO1 MAP1S ELL
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around COMP on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the COMP gene promoter:

Genomic Location for COMP Gene

Chromosome:
19
Start:
18,782,773 bp from pter
End:
18,791,314 bp from pter
Size:
8,542 bases
Orientation:
Minus strand

Genomic View for COMP Gene

Genes around COMP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COMP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COMP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COMP Gene

Proteins for COMP Gene

  • Protein details for COMP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49747-COMP_HUMAN
    Recommended name:
    Cartilage oligomeric matrix protein
    Protein Accession:
    P49747
    Secondary Accessions:
    • B4DKJ3
    • O14592
    • Q16388
    • Q16389
    • Q2NL86
    • Q8N4T2

    Protein attributes for COMP Gene

    Size:
    757 amino acids
    Molecular mass:
    82860 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Pentamer; disulfide-linked. Exists in a more compact conformation in the presence of calcium and shows a more extended conformation in the absence of calcium. Interacts with ITGB3, ITGA5 and FN1. Binding to FN1 requires the presence of divalent cations (Ca(2+), Mg(2+) or Mn(2+)). The greatest amount of binding is seen in the presence of Mn(2+). Interacts with MATN1, MATN3, MATN4 and ACAN. Binds heparin, heparan sulfate and chondroitin sulfate. EDTA dimishes significantly its binding to ACAN and abolishes its binding to MATN3, MATN4 and chondroitin sulfate. Interacts with collagen I, II and IX, and interaction with these collagens is dependent on the presence of zinc ions. Interacts with ADAMTS12. Interacts with ITGA7 (By similarity).
    SequenceCaution:
    • Sequence=AAB86501.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for COMP Gene

    Alternative splice isoforms for COMP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COMP Gene

Post-translational modifications for COMP Gene

  • Glycosylation at Asn121 and isoforms=2742
  • Modification sites at PhosphoSitePlus

Other Protein References for COMP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for COMP (COMP/Thrombospondin-5)
  • Abcam antibodies for COMP

Protein Products

  • Novus Biologicals lysates for COMP
  • Abcam proteins for COMP

Assay Products

No data available for DME Specific Peptides for COMP Gene

Domains & Families for COMP Gene

Suggested Antigen Peptide Sequences for COMP Gene

Graphical View of Domain Structure for InterPro Entry

P49747

UniProtKB/Swiss-Prot:

COMP_HUMAN :
  • The cell attachment motif mediates the attachment to chondrocytes. It mediates the induction of both the IAP family of survival proteins and the antiapoptotic response.
  • Belongs to the thrombospondin family.
Domain:
  • The cell attachment motif mediates the attachment to chondrocytes. It mediates the induction of both the IAP family of survival proteins and the antiapoptotic response.
  • The TSP C-terminal domain mediates interaction with FN1 and ACAN.
  • Each of the eight TSP type-3 repeats binds two calcium ions. The TSP C-terminal domain binds three calcium ions.
Family:
  • Belongs to the thrombospondin family.
genes like me logo Genes that share domains with COMP: view

No data available for Gene Families for COMP Gene

Function for COMP Gene

Molecular function for COMP Gene

GENATLAS Biochemistry:
cartilage oligomeric matrix glycoprotein (524kDa),cell adhesion molecule,thrombospondin family
UniProtKB/Swiss-Prot Function:
May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity).

Gene Ontology (GO) - Molecular Function for COMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 18485748
GO:0005201 extracellular matrix structural constituent TAS 7713493
GO:0005509 calcium ion binding IDA,TAS 10852928
GO:0005515 protein binding IPI 12225811
GO:0005518 collagen binding IDA 11084047
genes like me logo Genes that share ontologies with COMP: view
genes like me logo Genes that share phenotypes with COMP: view

Human Phenotype Ontology for COMP Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for COMP Gene

MGI Knock Outs for COMP:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for COMP

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for COMP Gene

Localization for COMP Gene

Subcellular locations from UniProtKB/Swiss-Prot for COMP Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for COMP gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 2
plasma membrane 1
cytoskeleton 1
nucleus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for COMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA,TAS --
GO:0005615 extracellular space IDA 20551380
GO:0031012 colocalizes_with extracellular matrix IDA 20551380
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with COMP: view

Pathways & Interactions for COMP Gene

genes like me logo Genes that share pathways with COMP: view

Pathways by source for COMP Gene

Gene Ontology (GO) - Biological Process for COMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development TAS 7670472
GO:0003417 growth plate cartilage development IEA --
GO:0006915 apoptotic process IEA --
GO:0007155 cell adhesion IEA --
GO:0009887 animal organ morphogenesis TAS 7713493
genes like me logo Genes that share ontologies with COMP: view

No data available for SIGNOR curated interactions for COMP Gene

Drugs & Compounds for COMP Gene

(15) Drugs for COMP Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra Target 0

(21) Additional Compounds for COMP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with COMP: view

Transcripts for COMP Gene

Unigene Clusters for COMP Gene

Cartilage oligomeric matrix protein:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for COMP

Alternative Splicing Database (ASD) splice patterns (SP) for COMP Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
SP1: -
SP2: -
SP3: - -
SP4: - - -
SP5:

Relevant External Links for COMP Gene

GeneLoc Exon Structure for
COMP
ECgene alternative splicing isoforms for
COMP

Expression for COMP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for COMP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for COMP Gene

This gene is overexpressed in Artery - Tibial (x17.8), Artery - Aorta (x4.9), and Adipose - Subcutaneous (x4.9).

Protein differential expression in normal tissues from HIPED for COMP Gene

This gene is overexpressed in Synovial fluid (47.1) and Monocytes (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for COMP Gene



NURSA nuclear receptor signaling pathways regulating expression of COMP Gene:

COMP

SOURCE GeneReport for Unigene cluster for COMP Gene:

Hs.1584

mRNA Expression by UniProt/SwissProt for COMP Gene:

P49747-COMP_HUMAN
Tissue specificity: Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. Increased amounts are produced during late stages of osteoarthritis in the area adjacent to the main defect.

Evidence on tissue expression from TISSUES for COMP Gene

  • Bone(4.1)
  • Liver(4.1)
  • Muscle(2.6)
  • Blood(2.2)
  • Heart(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for COMP Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • immune
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
Organs:
Head and neck:
  • brain
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • neck
  • skull
Thorax:
  • chest wall
  • clavicle
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
Pelvis:
  • pelvis
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • peripheral nerve
  • peripheral nervous system
  • spinal column
  • spinal cord
  • vertebrae
genes like me logo Genes that share expression patterns with COMP: view

Primer Products

No data available for Protein tissue co-expression partners for COMP Gene

Orthologs for COMP Gene

This gene was present in the common ancestor of animals.

Orthologs for COMP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COMP 34 35
  • 99.6 (n)
dog
(Canis familiaris)
Mammalia COMP 34 35
  • 88.49 (n)
cow
(Bos Taurus)
Mammalia COMP 34 35
  • 87.99 (n)
oppossum
(Monodelphis domestica)
Mammalia COMP 35
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Comp 34 16 35
  • 84.53 (n)
rat
(Rattus norvegicus)
Mammalia Comp 34
  • 84.04 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia COMP 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves COMP 34 35
  • 70.35 (n)
lizard
(Anolis carolinensis)
Reptilia COMP 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia comp 34
  • 65.65 (n)
zebrafish
(Danio rerio)
Actinopterygii COMP 35
  • 68 (a)
OneToOne
im:7154332 34
  • 66.81 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002157 34
  • 62.35 (n)
fruit fly
(Drosophila melanogaster)
Insecta Tsp 36 34 35
  • 56.76 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 56 (a)
OneToMany
Species where no ortholog for COMP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COMP Gene

ENSEMBL:
Gene Tree for COMP (if available)
TreeFam:
Gene Tree for COMP (if available)

Paralogs for COMP Gene

Paralogs for COMP Gene

(5) SIMAP similar genes for COMP Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with COMP: view

Variants for COMP Gene

Sequence variations from dbSNP and Humsavar for COMP Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs137852650 Pathogenic, Pseudoachondroplasia (PSACH) [MIM:177170] 18,786,040(-) ACGAC(G/T)ACGAC reference, missense
rs137852651 Pathogenic, Pseudoachondroplasia (PSACH) [MIM:177170] 18,786,051(-) TGCCT(A/G)CGACG reference, missense
rs137852652 Pathogenic, Multiple epiphyseal dysplasia 1 (EDM1) [MIM:132400] 18,787,602(-) ACGAG(G/T)ACAAG reference, missense
rs137852653 Pathogenic, Pseudoachondroplasia (PSACH) [MIM:177170] 18,787,644(-) ACAAC(C/T)GCCCG reference, missense
rs137852654 Pathogenic, Multiple epiphyseal dysplasia 1 (EDM1) [MIM:132400] 18,785,772(-) GAGAA(C/G)GCTGA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for COMP Gene

Variant ID Type Subtype PubMed ID
esv3643845 CNV loss 21293372
nsv1151217 CNV deletion 26484159
nsv833777 CNV loss 17160897
nsv952422 CNV deletion 24416366

Variation tolerance for COMP Gene

Residual Variation Intolerance Score: 17.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.67; 65.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COMP Gene

Human Gene Mutation Database (HGMD)
COMP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
COMP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COMP Gene

Disorders for COMP Gene

MalaCards: The human disease database

(32) MalaCards diseases for COMP Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pseudoachondroplasia
  • pseudoachondroplastic dysplasia
epiphyseal dysplasia, multiple, 1
  • multiple epiphyseal dysplasia 1
multiple epiphyseal dysplasia
  • epiphyseal dysplasia, multiple, 2
osteoarthritis
  • arthropathy
relapsing polychondritis
  • chondromalacia, systemic
- elite association - COSMIC cancer census association via MalaCards
Search COMP in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

COMP_HUMAN
  • Multiple epiphyseal dysplasia 1 (EDM1) [MIM:132400]: A generalized skeletal dysplasia associated with significant morbidity. Joint pain, joint deformity, waddling gait, and short stature are the main clinical signs and symptoms. Radiological examination of the skeleton shows delayed, irregular mineralization of the epiphyseal ossification centers and of the centers of the carpal and tarsal bones. Multiple epiphyseal dysplasia is broadly categorized into the more severe Fairbank and the milder Ribbing types. The Fairbank type is characterized by shortness of stature, short and stubby fingers, small epiphyses in several joints, including the knee, ankle, hand, and hip. The Ribbing type is confined predominantly to the hip joints and is characterized by hands that are normal and stature that is normal or near-normal. {ECO:0000269 PubMed:11084047, ECO:0000269 PubMed:11565064, ECO:0000269 PubMed:21922596, ECO:0000269 PubMed:7670472, ECO:0000269 PubMed:9021009, ECO:0000269 PubMed:9184241, ECO:0000269 PubMed:9452026, ECO:0000269 PubMed:9463320, ECO:0000269 PubMed:9921895}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Pseudoachondroplasia (PSACH) [MIM:177170]: A skeletal dysplasia usually manifesting in the second year of life and characterized by moderate to severe disproportionate short stature, deformity of the lower limbs, brachydactyly, ligamentous laxity, and degenerative joint disease. {ECO:0000269 PubMed:10852928, ECO:0000269 PubMed:11084047, ECO:0000269 PubMed:11746044, ECO:0000269 PubMed:11746045, ECO:0000269 PubMed:21922596, ECO:0000269 PubMed:7670471, ECO:0000269 PubMed:7670472, ECO:0000269 PubMed:9184241, ECO:0000269 PubMed:9452026, ECO:0000269 PubMed:9452063, ECO:0000269 PubMed:9463320, ECO:0000269 PubMed:9921895}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for COMP

Genetic Association Database (GAD)
COMP
Human Genome Epidemiology (HuGE) Navigator
COMP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COMP
genes like me logo Genes that share disorders with COMP: view

No data available for Genatlas for COMP Gene

Publications for COMP Gene

  1. The crystal structure of the signature domain of cartilage oligomeric matrix protein: implications for collagen, glycosaminoglycan and integrin binding. (PMID: 19276170) Tan K. … Lawler J. (FASEB J. 2009) 3 4 22 64
  2. Cartilage oligomeric matrix protein protects cells against death by elevating members of the IAP family of survival proteins. (PMID: 17993464) Gagarina V. … Hall D.J. (J. Biol. Chem. 2008) 3 4 22 64
  3. Interaction of cartilage oligomeric matrix protein/thrombospondin 5 with aggrecan. (PMID: 17588949) Chen F.-H. … Lawler J. (J. Biol. Chem. 2007) 3 4 25 64
  4. ADAMTS-12 associates with and degrades cartilage oligomeric matrix protein. (PMID: 16611630) Liu C.-J. … Di Cesare P.E. (J. Biol. Chem. 2006) 3 4 22 64
  5. Cartilage oligomeric matrix protein is involved in human limb development and in the pathogenesis of osteoarthritis. (PMID: 16542502) Koelling S. … Miosge N. (Arthritis Res. Ther. 2006) 3 4 22 64

Products for COMP Gene

  • Addgene plasmids for COMP

Sources for COMP Gene

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