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Aliases for COMMD9 Gene

Aliases for COMMD9 Gene

  • COMM Domain Containing 9 2 3 5
  • HSPC166 3

External Ids for COMMD9 Gene

Previous GeneCards Identifiers for COMMD9 Gene

  • GC11M036260
  • GC11M036251
  • GC11M035993

Summaries for COMMD9 Gene

GeneCards Summary for COMMD9 Gene

COMMD9 (COMM Domain Containing 9) is a Protein Coding gene.

UniProtKB/Swiss-Prot for COMMD9 Gene

  • May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits (PubMed:23637203).

Gene Wiki entry for COMMD9 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COMMD9 Gene

Genomics for COMMD9 Gene

Regulatory Elements for COMMD9 Gene

Enhancers for COMMD9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around COMMD9 on UCSC Golden Path with GeneCards custom track

Promoters for COMMD9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around COMMD9 on UCSC Golden Path with GeneCards custom track

Genomic Location for COMMD9 Gene

Chromosome:
11
Start:
36,269,284 bp from pter
End:
36,289,449 bp from pter
Size:
20,166 bases
Orientation:
Minus strand

Genomic View for COMMD9 Gene

Genes around COMMD9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COMMD9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COMMD9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COMMD9 Gene

Proteins for COMMD9 Gene

  • Protein details for COMMD9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P000-COMD9_HUMAN
    Recommended name:
    COMM domain-containing protein 9
    Protein Accession:
    Q9P000
    Secondary Accessions:
    • E9PAN2
    • Q96FI2
    • Q9H0R0

    Protein attributes for COMMD9 Gene

    Size:
    198 amino acids
    Molecular mass:
    21819 Da
    Quaternary structure:
    • Interacts with RELB and NFKB1/p105. Interacts with CCDC22, CCDC93, SCNN1B, CUL1.

    Three dimensional structures from OCA and Proteopedia for COMMD9 Gene

    Alternative splice isoforms for COMMD9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COMMD9 Gene

Proteomics data for COMMD9 Gene at MOPED

Post-translational modifications for COMMD9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for COMMD9 Gene

No data available for DME Specific Peptides for COMMD9 Gene

Domains & Families for COMMD9 Gene

Gene Families for COMMD9 Gene

Protein Domains for COMMD9 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9P000

UniProtKB/Swiss-Prot:

COMD9_HUMAN :
  • Contains 1 COMM domain.
Domain:
  • Contains 1 COMM domain.
genes like me logo Genes that share domains with COMMD9: view

Function for COMMD9 Gene

Molecular function for COMMD9 Gene

UniProtKB/Swiss-Prot Function:
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits (PubMed:23637203).
genes like me logo Genes that share phenotypes with COMMD9: view

Animal Models for COMMD9 Gene

MGI Knock Outs for COMMD9:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for COMMD9 Gene

Localization for COMMD9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COMMD9 Gene

Nucleus. Cytoplasmic vesicle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COMMD9 Gene COMPARTMENTS Subcellular localization image for COMMD9 gene
Compartment Confidence
nucleus 4
cytosol 3
golgi apparatus 2
endosome 1
extracellular 1
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for COMMD9 Gene

Pathways & Interactions for COMMD9 Gene

SuperPathways for COMMD9 Gene

No Data Available

Interacting Proteins for COMMD9 Gene

Gene Ontology (GO) - Biological Process for COMMD9 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for COMMD9 Gene

Drugs & Compounds for COMMD9 Gene

No Compound Related Data Available

Transcripts for COMMD9 Gene

Unigene Clusters for COMMD9 Gene

COMM domain containing 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COMMD9 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c
SP1: - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - -
SP7:
SP8:
SP9: - - - - - - - -

Relevant External Links for COMMD9 Gene

GeneLoc Exon Structure for
COMMD9
ECgene alternative splicing isoforms for
COMMD9

Expression for COMMD9 Gene

mRNA expression in normal human tissues for COMMD9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for COMMD9 Gene



SOURCE GeneReport for Unigene cluster for COMMD9 Gene Hs.279836

mRNA Expression by UniProt/SwissProt for COMMD9 Gene

Q9P000-COMD9_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with COMMD9: view

Protein tissue co-expression partners for COMMD9 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for COMMD9 Gene

Orthologs for COMMD9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for COMMD9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia COMMD9 35
  • 87.71 (n)
  • 93.94 (a)
COMMD9 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COMMD9 35
  • 89.73 (n)
  • 95.45 (a)
COMMD9 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Commd9 35
  • 86.36 (n)
  • 89.9 (a)
Commd9 16
Commd9 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia COMMD9 35
  • 99.49 (n)
  • 98.99 (a)
COMMD9 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Commd9 35
  • 88.72 (n)
  • 93.94 (a)
oppossum
(Monodelphis domestica)
Mammalia COMMD9 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COMMD9 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves COMMD9 35
  • 68.87 (n)
  • 72.08 (a)
COMMD9 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COMMD9 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia commd9 35
  • 64.81 (n)
  • 66.67 (a)
Str.100 35
zebrafish
(Danio rerio)
Actinopterygii commd9 35
  • 61.08 (n)
  • 61.42 (a)
commd9 36
  • 61 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
OneToOne
Species with no ortholog for COMMD9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COMMD9 Gene

ENSEMBL:
Gene Tree for COMMD9 (if available)
TreeFam:
Gene Tree for COMMD9 (if available)

Paralogs for COMMD9 Gene

No data available for Paralogs for COMMD9 Gene

Variants for COMMD9 Gene

Sequence variations from dbSNP and Humsavar for COMMD9 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2028901 -- 36,288,178(+) TACTT(A/G)TTGGG intron-variant
rs2028902 -- 36,288,360(+) TGTTT(A/T)AAAAA intron-variant
rs2028903 -- 36,288,375(+) AAAAA(A/G)AGAGA intron-variant
rs2028904 -- 36,288,431(+) AGACG(C/G)ACAAC intron-variant
rs2197601 -- 36,285,793(-) ATATC(A/T)TGTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COMMD9 Gene

Variant ID Type Subtype PubMed ID
esv2422305 CNV Duplication 17116639
nsv467791 CNV Gain 19166990
esv2744346 CNV Deletion 23290073
esv1531905 CNV Insertion 17803354
esv2744347 CNV Deletion 23290073
nsv513312 CNV Insertion 21212237

Variation tolerance for COMMD9 Gene

Residual Variation Intolerance Score: 73.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.59; 30.68% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for COMMD9 Gene

Disorders for COMMD9 Gene

Relevant External Links for COMMD9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COMMD9

No disorders were found for COMMD9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COMMD9 Gene

Publications for COMMD9 Gene

  1. COMMD proteins, a novel family of structural and functional homologs of MURR1. (PMID: 15799966) Burstein E. … Duckett C.S. (J. Biol. Chem. 2005) 2 3 4 67
  2. COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A. (PMID: 25355947) Phillips-Krawczak C.A. … Burstein E. (Mol. Biol. Cell 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for COMMD9 Gene

Sources for COMMD9 Gene

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