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Aliases for COMMD9 Gene

Aliases for COMMD9 Gene

  • COMM Domain Containing 9 2 3
  • COMM Domain-Containing Protein 9 3
  • HSPC166 3
  • COMM9 6

External Ids for COMMD9 Gene

Previous GeneCards Identifiers for COMMD9 Gene

  • GC11M036260
  • GC11M036251
  • GC11M035993

Summaries for COMMD9 Gene

GeneCards Summary for COMMD9 Gene

COMMD9 (COMM Domain Containing 9) is a Protein Coding gene.

UniProtKB/Swiss-Prot for COMMD9 Gene

  • May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits (PubMed:23637203).

Gene Wiki entry for COMMD9 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COMMD9 Gene

Genomics for COMMD9 Gene

Regulatory Elements for COMMD9 Gene

Genomic Location for COMMD9 Gene

Start:
36,269,284 bp from pter
End:
36,289,449 bp from pter
Size:
20,166 bases
Orientation:
Minus strand

Genomic View for COMMD9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COMMD9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COMMD9 Gene

Proteins for COMMD9 Gene

  • Protein details for COMMD9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P000-COMD9_HUMAN
    Recommended name:
    COMM domain-containing protein 9
    Protein Accession:
    Q9P000
    Secondary Accessions:
    • E9PAN2
    • Q96FI2
    • Q9H0R0

    Protein attributes for COMMD9 Gene

    Size:
    198 amino acids
    Molecular mass:
    21819 Da
    Quaternary structure:
    • Interacts with RELB and NFKB1/p105. Interacts with CCDC22, CCDC93, SCNN1B, CUL1.

    Three dimensional structures from OCA and Proteopedia for COMMD9 Gene

    Alternative splice isoforms for COMMD9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COMMD9 Gene

Proteomics data for COMMD9 Gene at MOPED

Post-translational modifications for COMMD9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for COMMD9 Gene

No data available for DME Specific Peptides for COMMD9 Gene

Domains for COMMD9 Gene

Protein Domains for COMMD9 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9P000

UniProtKB/Swiss-Prot:

COMD9_HUMAN :
  • Q9P000
Domain:
  • Contains 1 COMM domain.
genes like me logo Genes that share domains with COMMD9: view

No data available for Gene Families for COMMD9 Gene

Function for COMMD9 Gene

Molecular function for COMMD9 Gene

UniProtKB/Swiss-Prot Function: May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits (PubMed:23637203).

Gene Ontology (GO) - Molecular Function for COMMD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21778237
genes like me logo Genes that share ontologies with COMMD9: view

miRNA for COMMD9 Gene

miRTarBase miRNAs that target COMMD9

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for COMMD9 Gene

Localization for COMMD9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COMMD9 Gene

Nucleus. Cytoplasmic vesicle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COMMD9 Gene COMPARTMENTS Subcellular localization image for COMMD9 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for COMMD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0016023 cytoplasmic membrane-bounded vesicle IEA --
genes like me logo Genes that share ontologies with COMMD9: view

Pathways for COMMD9 Gene

SuperPathways for COMMD9 Gene

No Data Available

Interacting Proteins for COMMD9 Gene

Gene Ontology (GO) - Biological Process for COMMD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006814 sodium ion transport IEA --
genes like me logo Genes that share ontologies with COMMD9: view

No data available for Pathways by source for COMMD9 Gene

Transcripts for COMMD9 Gene

Unigene Clusters for COMMD9 Gene

COMM domain containing 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COMMD9 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c
SP1: - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - -
SP7:
SP8:
SP9: - - - - - - - -

Relevant External Links for COMMD9 Gene

GeneLoc Exon Structure for
COMMD9
ECgene alternative splicing isoforms for
COMMD9

Expression for COMMD9 Gene

mRNA expression in normal human tissues for COMMD9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COMMD9 Gene

SOURCE GeneReport for Unigene cluster for COMMD9 Gene Hs.279836

mRNA Expression by UniProt/SwissProt for COMMD9 Gene

Q9P000-COMD9_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with COMMD9: view

No data available for mRNA differential expression in normal tissues for COMMD9 Gene

Orthologs for COMMD9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for COMMD9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COMMD9 35
  • 99.49 (n)
  • 98.99 (a)
COMMD9 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia COMMD9 35
  • 87.71 (n)
  • 93.94 (a)
COMMD9 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COMMD9 35
  • 89.73 (n)
  • 95.45 (a)
COMMD9 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Commd9 35
  • 86.36 (n)
  • 89.9 (a)
Commd9 16
Commd9 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia COMMD9 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COMMD9 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Commd9 35
  • 88.72 (n)
  • 93.94 (a)
chicken
(Gallus gallus)
Aves COMMD9 35
  • 68.87 (n)
  • 72.08 (a)
COMMD9 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COMMD9 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia commd9 35
  • 64.81 (n)
  • 66.67 (a)
Str.100 35
zebrafish
(Danio rerio)
Actinopterygii commd9 35
  • 61.08 (n)
  • 61.42 (a)
commd9 36
  • 61 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
OneToOne
Species with no ortholog for COMMD9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COMMD9 Gene

ENSEMBL:
Gene Tree for COMMD9 (if available)
TreeFam:
Gene Tree for COMMD9 (if available)

Paralogs for COMMD9 Gene

No data available for Paralogs for COMMD9 Gene

Variants for COMMD9 Gene

Sequence variations from dbSNP and Humsavar for COMMD9 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs2028901 -- 36,288,178(+) TACTT(A/G)TTGGG intron-variant
rs2028902 -- 36,288,360(+) TGTTT(A/T)AAAAA intron-variant
rs2028903 -- 36,288,375(+) AAAAA(A/G)AGAGA intron-variant
rs2028904 -- 36,288,431(+) AGACG(C/G)ACAAC intron-variant
rs2197601 -- 36,285,793(-) ATATC(A/T)TGTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COMMD9 Gene

Variant ID Type Subtype PubMed ID
esv2422305 CNV Duplication 17116639
nsv467791 CNV Gain 19166990
esv2744346 CNV Deletion 23290073
esv1531905 CNV Insertion 17803354
esv2744347 CNV Deletion 23290073
nsv513312 CNV Insertion 21212237

Relevant External Links for COMMD9 Gene

HapMap Linkage Disequilibrium report
COMMD9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COMMD9 Gene

Disorders for COMMD9 Gene

(1) University of Copenhagen DISEASES for COMMD9 Gene

genes like me logo Genes that share disorders with COMMD9: view

No data available for UniProtKB/Swiss-Prot for COMMD9 Gene

Publications for COMMD9 Gene

  1. COMMD proteins, a novel family of structural and functional homologs of MURR1. (PMID: 15799966) Burstein E. … Duckett C.S. (J. Biol. Chem. 2005) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  5. CCDC22 deficiency in humans blunts activation of proinflammatory NF-I_B signaling. (PMID: 23563313) Starokadomskyy P. … Burstein E. (J. Clin. Invest. 2013) 3 4

Products for COMMD9 Gene

Sources for COMMD9 Gene

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