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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

COMMD9 Gene

protein-coding GIFtS: 48
GCID: GC11M036251

COMM domain containing 9

Explore 1 disease affiliated with
COMMD9 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
COMM Domain Containing 9¹ ²
FLJ31106¹
HSPC166¹
COMM Domain-Containing Protein 9²
COMM9⁵

External Ids:	HGNC: 25014¹	Entrez Gene: 29099²	Ensembl: ENSG00000110442⁷	OMIM: 612299⁵	UniProtKB: Q9P000³

Export aliases for COMMD9 gene to outside databases

Previous GC identifers: GC11M036260 GC11M035993

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for COMMD9

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the COMMD9 gene promoter:
GR GR-beta FOXO3 CUTL1 E47 FOXO3b AREB6 FOXO3a Hand1 GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: COMMD9 promoter sequence

Search SABiosciences Chromatin IP Primers for COMMD9

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COMMD9

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p13 Ensembl cytogenetic band: 11p13 HGNC cytogenetic band: 11p13

COMMD9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COMMD9 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M036251: view genomic region (about GC identifiers)

Start:	36,293,842 bp from pter	End:	36,310,999 bp from pter
Size:	17,158 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: COMD9_HUMAN, Q9P000 (See protein sequence)

Recommended Name: COMM domain-containing protein 9

Size: 198 amino acids; 21819 Da

Secondary accessions: E9PAN2 Q96FI2 Q9H0R0

Alternative splicing: 2 isoforms: Q9P000-1 Q9P000-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for COMMD9: NX_Q9P000

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9P000

COMMD9 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001095123.1 NP_054905.2

ENSEMBL proteins:

ENSP00000263401 ENSP00000392510 ENSP00000435599

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

COMMD9 for domains About GeneDecksing

2 InterPro domains/families:

IPR017920 COMM

IPR009886 HCaRG

Graphical View of Domain Structure for InterPro Entry Q9P000

ProtoNet protein and cluster: Q9P000

1 Blocks protein family: IPB009886 HCaRG

UniProtKB/Swiss-Prot: COMD9_HUMAN, Q9P000

Similarity: Contains 1 COMM domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for COMMD9

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

3 Interacting proteins for COMMD9 (Q9P000³ ENSP00000263401⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NFKB1	P19838³, ENSP00000226574⁴	I2D: score=1 STRING: ENSP00000226574
RELB	Q01201³, ENSP00000221452⁴	I2D: score=1 STRING: ENSP00000221452
SLC2A4	P14672³	I2D: score=1

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for COMMD9
Search CenterWatch for drugs/clinical trials and news about COMMD9 / COMD9

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for COMMD9 gene (2 alternative transcripts):

NM_001101653.1 NM_014186.3

Unigene Cluster for COMMD9:

COMM domain containing 9

Hs.279836 [show with all ESTs]

Unigene Representative Sequence: NM_014186

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000263401(uc001mwn.4 uc009ykj.3) ENST00000533308 ENST00000452374

ENST00000532705 ENST00000533643 ENST00000528608(uc010rfb.1) ENST00000526789

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Additional cDNA sequence:

AF161515.1 AK055668.1 AK223213.1 AK290065.1 AK295590.1 AK298978.1 AK314477.1 AL136688.1

AY542164.1 BC010892.1 BC092458.1 BC108685.1

10 DOTS entries:

DT.446482 DT.75148828 DT.120719861 DT.100799646 DT.100799651 DT.75198311 DT.86852726 DT.100799650

DT.95121185 DT.95121191

24/237 AceView cDNA sequences (see all 237):

BM460774 BG575230 CR590294 CR599139 BG681560 BQ423043 CD519058 BU541298

BM738703 CR595405 BQ187958 BM823310 BM463955 BM740716 BM745348 AI949236

BM769153 BE407367 BI764070 CR612003 BM708444 BM923998 CF127764 BQ068304

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for COMMD9 (see all 9) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5a	·	5b	·	5c	^	6	^	7a	·	7b	^	8a	·	8b	·	8c	·	8d	^	9a	·	9b	·	9c
SP1:							-		-						-		-				-										-
SP2:							-		-						-		-				-
SP3:															-		-				-
SP4:							-		-		-				-		-				-
SP5:							-		-						-		-		-		-

ECgene alternative splicing isoforms for COMMD9

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

COMMD9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAACCAGGGC

About this image

COMMD9 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Bone

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See COMMD9 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for COMMD9

SOURCE GeneReport for Unigene cluster: Hs.279836

UniProtKB/Swiss-Prot: COMD9_HUMAN, Q9P000

Tissue specificity: Ubiquitous

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for COMMD9 gene from 5/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Commd9^{1 , 5}	COMM domain containing 9^{1, 5}	86.36(n)¹ 89.9(a)¹		2 (54.07 cM)⁵ 76501¹ NM_029635.3¹ NP_083911.1¹ 101886247⁵
chicken (Gallus gallus)	Aves	COMMD9¹	COMM domain containing 9	68.87(n) 72.08(a)		423161 XM_421087.3 XP_421087.2
lizard (Anolis carolinensis)	Reptilia	COMMD9⁶	--	74(a)	1 ↔ 1	1(53734253-53738883)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.100²	Transcribed sequence with weak similarity to protein more	78.74(n)		142015251
zebrafish (Danio rerio)	Actinopterygii	commd9¹	COMM domain containing 9	60.74(n) 61.42(a)		562660 NM_001089398.1 NP_001082867.1

ENSEMBL Gene Tree for COMMD9 (if available)
TreeFam Gene Tree for COMMD9 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs71044567^1,2	C,	--	36297021(-)	`GAGTG-/AGAC TCCGT`	2	--	int¹		1		NA	2
rs79468939^1,2	C	--	36305693(+)	`AACAA-/CAAATCTC`	1	--	int¹		0	--	--	--	--
rs2028903^1,2	C,H,	--	36309925(+)	`AAAAAA/GAGAGA`	1	--	int¹ trp³		7		NA WA CSA	13
rs112439302^1,2	--	--	36309925(+)	`AAAAAG/-AGAGA`	1	--	int¹		1		CSA	2
rs71481467^1,2	--	--	36297013(-)	`GAGTGTCCGTCTC/AG ACTCCGTCTCAAAAAA`	2	--	int¹		1		NA	2

HapMap Linkage Disequilibrium report for COMMD9 (36293842 - 36310999 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for COMMD9
3 CNVs: 5274 85722 75598

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

COMMD9 for disorders           About GeneDecksing

OMIM gene information: 612299    OMIM disorders: --

1 disease for COMMD9:    About MalaCards

newcastle disease

1 disease from the University of Copenhagen DISEASES database for COMMD9:

Newcastle disease

Export disorders for COMMD9 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for COMMD9 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with COMMD9)

Utopia: connect your pdf to the dynamic
world of online information

COMMD proteins, a novel family of structural and functional homologs of MURR1. (PubMed id 15799966)^{1, 2, 3} Burstein E....Duckett C.S. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2} Wiemann S.... Poustka A. (2001)
Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)^{1, 2} Zhang Q.-H.... Chen Z. (2000)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)² Taylor T.D....Sakaki Y. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 29099	HGNC: 25014	AceView: COMMD9andFLJ45212	Ensembl:ENSG00000110442	euGenes: HUgn29099
ECgene: COMMD9	H-InvDB: COMMD9

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for COMMD9	Pharmacogenomics, SNPs, Pathways

Intellectual Property for COMMD9 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for COMMD9 gene:
Search GeneIP for patents involving COMMD9

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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	GenScript Custom Purified and Recombinant Proteins Services for COMMD9		GenScript cDNA clones with any tag delivered in your preferred vector for COMMD9
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	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COMMD9

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes COMMD9 gene at Home site.

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COMMD9 Gene

COMM domain containing 9

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COMMD9 Gene

COMM domain containing 9

Aliasesfor COMMD9 gene

Summariesfor COMMD9 gene

Genomic Viewsfor COMMD9 gene

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Protein Domains /Familiesfor COMMD9 gene

Functionfor COMMD9 gene

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for COMMD9 gene

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for COMMD9 gene

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