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Aliases for COMMD8 Gene

Aliases for COMMD8 Gene

  • COMM Domain Containing 8 2 3 5

External Ids for COMMD8 Gene

Previous GeneCards Identifiers for COMMD8 Gene

  • GC04M047293
  • GC04M047147
  • GC04M046772

Summaries for COMMD8 Gene

GeneCards Summary for COMMD8 Gene

COMMD8 (COMM Domain Containing 8) is a Protein Coding gene.

UniProtKB/Swiss-Prot for COMMD8 Gene

  • May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COMMD8 Gene

Genomics for COMMD8 Gene

Regulatory Elements for COMMD8 Gene

Promoters for COMMD8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around COMMD8 on UCSC Golden Path with GeneCards custom track

Genomic Location for COMMD8 Gene

Chromosome:
4
Start:
47,450,793 bp from pter
End:
47,463,719 bp from pter
Size:
12,927 bases
Orientation:
Minus strand

Genomic View for COMMD8 Gene

Genes around COMMD8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COMMD8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COMMD8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COMMD8 Gene

Proteins for COMMD8 Gene

  • Protein details for COMMD8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NX08-COMD8_HUMAN
    Recommended name:
    COMM domain-containing protein 8
    Protein Accession:
    Q9NX08
    Secondary Accessions:
    • Q8WUR4
    • Q9HC15

    Protein attributes for COMMD8 Gene

    Size:
    183 amino acids
    Molecular mass:
    21090 Da
    Quaternary structure:
    • Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with RELA, RELB, NFKB1/p105. Interacts with CCDC22, CCDC93, SCNN1B, CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5.
    SequenceCaution:
    • Sequence=AAG14957.1; Type=Frameshift; Positions=11; Evidence={ECO:0000305};

neXtProt entry for COMMD8 Gene

Proteomics data for COMMD8 Gene at MOPED

Post-translational modifications for COMMD8 Gene

  • Ubiquitination at Lys 132
  • Modification sites at PhosphoSitePlus

Other Protein References for COMMD8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for COMMD8 Gene

Domains & Families for COMMD8 Gene

Gene Families for COMMD8 Gene

Protein Domains for COMMD8 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for COMMD8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NX08

UniProtKB/Swiss-Prot:

COMD8_HUMAN :
  • Contains 1 COMM domain.
Domain:
  • Contains 1 COMM domain.
genes like me logo Genes that share domains with COMMD8: view

Function for COMMD8 Gene

Molecular function for COMMD8 Gene

UniProtKB/Swiss-Prot Function:
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966).
genes like me logo Genes that share phenotypes with COMMD8: view

Animal Model Products

miRNA for COMMD8 Gene

miRTarBase miRNAs that target COMMD8

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COMMD8 Gene

Localization for COMMD8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COMMD8 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COMMD8 Gene COMPARTMENTS Subcellular localization image for COMMD8 gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for COMMD8 Gene

Pathways & Interactions for COMMD8 Gene

SuperPathways for COMMD8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for COMMD8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for COMMD8 Gene

Drugs & Compounds for COMMD8 Gene

No Compound Related Data Available

Transcripts for COMMD8 Gene

mRNA/cDNA for COMMD8 Gene

Unigene Clusters for COMMD8 Gene

COMM domain containing 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COMMD8 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1: - -
SP2: - -
SP3: - -
SP4: -
SP5:

Relevant External Links for COMMD8 Gene

GeneLoc Exon Structure for
COMMD8
ECgene alternative splicing isoforms for
COMMD8

Expression for COMMD8 Gene

mRNA expression in normal human tissues for COMMD8 Gene

Protein differential expression in normal tissues from HIPED for COMMD8 Gene

This gene is overexpressed in Rectum (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for COMMD8 Gene



SOURCE GeneReport for Unigene cluster for COMMD8 Gene Hs.23956

mRNA Expression by UniProt/SwissProt for COMMD8 Gene

Q9NX08-COMD8_HUMAN
Tissue specificity: Widely expressed with highest expression in thyroid.
genes like me logo Genes that share expression patterns with COMMD8: view

Protein tissue co-expression partners for COMMD8 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for COMMD8 Gene

Orthologs for COMMD8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for COMMD8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia COMMD8 35
  • 88.89 (n)
  • 83.61 (a)
COMMD8 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COMMD8 35
  • 89.25 (n)
  • 85.79 (a)
COMMD8 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Commd8 35
  • 79.05 (n)
  • 76.5 (a)
Commd8 16
Commd8 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia COMMD8 35
  • 99.82 (n)
  • 99.45 (a)
COMMD8 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Commd8 35
  • 80.69 (n)
  • 79.78 (a)
oppossum
(Monodelphis domestica)
Mammalia COMMD8 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COMMD8 36
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves COMMD8 35
  • 71.12 (n)
  • 65.12 (a)
COMMD8 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COMMD8 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia commd8 35
  • 63.75 (n)
  • 57.92 (a)
Str.15114 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.24752 35
zebrafish
(Danio rerio)
Actinopterygii commd8 35
  • 53.68 (n)
  • 49.42 (a)
commd8 36
  • 47 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9137 35
Species with no ortholog for COMMD8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COMMD8 Gene

ENSEMBL:
Gene Tree for COMMD8 (if available)
TreeFam:
Gene Tree for COMMD8 (if available)

Paralogs for COMMD8 Gene

Pseudogenes.org Pseudogenes for COMMD8 Gene

genes like me logo Genes that share paralogs with COMMD8: view

No data available for Paralogs for COMMD8 Gene

Variants for COMMD8 Gene

Sequence variations from dbSNP and Humsavar for COMMD8 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs35444219 - 47,463,603(+) CTCGG(C/G)CGGCA reference, missense
rs4356892 -- 47,461,828(+) GCCCT(A/G)CCATA intron-variant
rs4356893 -- 47,462,229(+) CCCAG(A/G)TGCCT intron-variant
rs4370115 -- 47,463,948(+) CGAAT(A/G)AAGGT upstream-variant-2KB
rs4585276 -- 47,465,169(+) ACGGT(G/T)ATCTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for COMMD8 Gene

Variant ID Type Subtype PubMed ID
nsv879005 CNV Loss 21882294
nsv829923 CNV Gain 17160897

Variation tolerance for COMMD8 Gene

Residual Variation Intolerance Score: 70.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.58; 44.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COMMD8 Gene

HapMap Linkage Disequilibrium report
COMMD8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COMMD8 Gene

Disorders for COMMD8 Gene

Relevant External Links for COMMD8

Genetic Association Database (GAD)
COMMD8
Human Genome Epidemiology (HuGE) Navigator
COMMD8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COMMD8

No disorders were found for COMMD8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COMMD8 Gene

Publications for COMMD8 Gene

  1. COMMD proteins, a novel family of structural and functional homologs of MURR1. (PMID: 15799966) Burstein E. … Duckett C.S. (J. Biol. Chem. 2005) 2 3 4 67
  2. COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A. (PMID: 25355947) Phillips-Krawczak C.A. … Burstein E. (Mol. Biol. Cell 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Proximity Interactions among Centrosome Components Identify Regulators of Centriole Duplication. (PMID: 24613305) Firat-Karalar E.N. … Stearns T. (Curr. Biol. 2014) 3

Products for COMMD8 Gene

Sources for COMMD8 Gene

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