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Aliases for COMMD8 Gene

Aliases for COMMD8 Gene

  • COMM Domain Containing 8 2 3

External Ids for COMMD8 Gene

Previous GeneCards Identifiers for COMMD8 Gene

  • GC04M047293
  • GC04M047147
  • GC04M046772

Summaries for COMMD8 Gene

GeneCards Summary for COMMD8 Gene

COMMD8 (COMM Domain Containing 8) is a Protein Coding gene.

UniProtKB/Swiss-Prot for COMMD8 Gene

  • May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COMMD8 Gene

Genomics for COMMD8 Gene

Regulatory Elements for COMMD8 Gene

Genomic Location for COMMD8 Gene

47,450,793 bp from pter
47,463,719 bp from pter
12,927 bases
Minus strand

Genomic View for COMMD8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COMMD8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COMMD8 Gene

Proteins for COMMD8 Gene

  • Protein details for COMMD8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    COMM domain-containing protein 8
    Protein Accession:
    Secondary Accessions:
    • Q8WUR4
    • Q9HC15

    Protein attributes for COMMD8 Gene

    183 amino acids
    Molecular mass:
    21090 Da
    Quaternary structure:
    • Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with RELA, RELB, NFKB1/p105. Interacts with CCDC22, CCDC93, SCNN1B, CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5.
    • Sequence=AAG14957.1; Type=Frameshift; Positions=11; Evidence={ECO:0000305};

neXtProt entry for COMMD8 Gene

Proteomics data for COMMD8 Gene at MOPED

Post-translational modifications for COMMD8 Gene

  • Ubiquitination at Lys132
  • Modification sites at PhosphoSitePlus

Other Protein References for COMMD8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for COMMD8 Gene

Domains for COMMD8 Gene

Protein Domains for COMMD8 Gene


Suggested Antigen Peptide Sequences for COMMD8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9NX08
  • Contains 1 COMM domain.
genes like me logo Genes that share domains with COMMD8: view

No data available for Gene Families for COMMD8 Gene

Function for COMMD8 Gene

Molecular function for COMMD8 Gene

UniProtKB/Swiss-Prot Function:
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966).

Gene Ontology (GO) - Molecular Function for COMMD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15799966
genes like me logo Genes that share ontologies with COMMD8: view

Phenotypes for COMMD8 Gene

GenomeRNAi human phenotypes for COMMD8:
genes like me logo Genes that share phenotypes with COMMD8: view

Animal Model Products

miRNA for COMMD8 Gene

miRTarBase miRNAs that target COMMD8

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for COMMD8 Gene

Localization for COMMD8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COMMD8 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for COMMD8 Gene COMPARTMENTS Subcellular localization image for COMMD8 gene
Compartment Confidence
cytosol 2
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for COMMD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with COMMD8: view

Pathways for COMMD8 Gene

SuperPathways for COMMD8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for COMMD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with COMMD8: view

No data available for Pathways by source for COMMD8 Gene

Transcripts for COMMD8 Gene

mRNA/cDNA for COMMD8 Gene

Unigene Clusters for COMMD8 Gene

COMM domain containing 8:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COMMD8

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COMMD8 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1: - -
SP2: - -
SP3: - -
SP4: -

Relevant External Links for COMMD8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COMMD8 Gene

mRNA expression in normal human tissues for COMMD8 Gene

Protein differential expression in normal tissues for COMMD8 Gene

This gene is overexpressed in Rectum (7.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COMMD8 Gene

SOURCE GeneReport for Unigene cluster for COMMD8 Gene Hs.23956

mRNA Expression by UniProt/SwissProt for COMMD8 Gene

Tissue specificity: Widely expressed with highest expression in thyroid.
genes like me logo Genes that share expressions with COMMD8: view

Expression partners for COMMD8 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for COMMD8 Gene

Orthologs for COMMD8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for COMMD8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia COMMD8 35
  • 88.89 (n)
  • 83.61 (a)
  • 84 (a)
(Canis familiaris)
Mammalia COMMD8 35
  • 89.25 (n)
  • 85.79 (a)
  • 86 (a)
(Mus musculus)
Mammalia Commd8 35
  • 79.05 (n)
  • 76.5 (a)
Commd8 16
Commd8 36
  • 77 (a)
(Pan troglodytes)
Mammalia COMMD8 35
  • 99.82 (n)
  • 99.45 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Commd8 35
  • 80.69 (n)
  • 79.78 (a)
(Monodelphis domestica)
Mammalia COMMD8 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia COMMD8 36
  • 57 (a)
(Gallus gallus)
Aves COMMD8 35
  • 71.12 (n)
  • 65.12 (a)
  • 64 (a)
(Anolis carolinensis)
Reptilia COMMD8 36
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia commd8 35
  • 63.75 (n)
  • 57.92 (a)
Str.15114 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.24752 35
(Danio rerio)
Actinopterygii commd8 35
  • 53.68 (n)
  • 49.42 (a)
commd8 36
  • 47 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9137 35
Species with no ortholog for COMMD8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COMMD8 Gene

Gene Tree for COMMD8 (if available)
Gene Tree for COMMD8 (if available)

Paralogs for COMMD8 Gene Pseudogenes for COMMD8 Gene

genes like me logo Genes that share paralogs with COMMD8: view

No data available for Paralogs for COMMD8 Gene

Variants for COMMD8 Gene

Sequence variations from dbSNP and Humsavar for COMMD8 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs4635794 -- 47,461,204(+) CTTCA(A/G)CATCT intron-variant
rs4694849 -- 47,459,730(+) ATACA(C/T)ACAAT intron-variant
rs4695232 -- 47,450,712(+) GTTAC(A/G)TATAA downstream-variant-500B
rs7656397 -- 47,453,597(+) AAATA(C/G)TGGTA intron-variant
rs7679955 -- 47,452,457(+) AAAAA(C/T)GTTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COMMD8 Gene

Variant ID Type Subtype PubMed ID
nsv879005 CNV Loss 21882294
nsv829923 CNV Gain 17160897

Relevant External Links for COMMD8 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COMMD8 Gene

Disorders for COMMD8 Gene

Relevant External Links for COMMD8

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for COMMD8 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for COMMD8 Gene

Publications for COMMD8 Gene

  1. COMMD proteins, a novel family of structural and functional homologs of MURR1. (PMID: 15799966) Burstein E. … Duckett C.S. (J. Biol. Chem. 2005) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. CCDC22 deficiency in humans blunts activation of proinflammatory NF-I_B signaling. (PMID: 23563313) Starokadomskyy P. … Burstein E. (J. Clin. Invest. 2013) 3 4

Products for COMMD8 Gene

Sources for COMMD8 Gene

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