COMMD8 Gene
protein-coding GIFtS: 48
GCID: GC04M047369
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|
COMM domain containing 8
| |
Aliases
for COMMD8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| COMM Domain Containing 81 2 | | FLJ205021 | | COMM Domain-Containing Protein 82 |
Export aliases for COMMD8 gene to outside databasesPrevious GC identifers: GC04M047293 GC04M047147 GC04M046772 |
Summaries
for COMMD8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for COMMD8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_006238.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the COMMD8 gene promoter:
TBP Pbx1a XBP-1 C/EBPalpha GATA-1 FOXJ2 (long isoform) TFIID FOXJ2 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for COMMD8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COMMD8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4p12 Ensembl cytogenetic band: 4p12 HGNC cytogenetic band: 4p12COMMD8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M047369: view genomic region
(about GC identifiers)
Start:
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47,452,815 bp from pter |
End:
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47,465,736 bp from pter |
Size:
|
12,922 bases |
Orientation:
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minus strand |
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Proteins
for COMMD8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: COMD8_HUMAN, Q9NX08 (See
protein sequence)Recommended Name: COMM domain-containing protein 8 Size: 183 amino acids; 21090 Da
Subunit: Interacts (via COMM domain) with COMMD1 (via COMM domain)
Sequence caution: Sequence=AAG14957.1; Type=Frameshift; Positions=11;
Secondary accessions: Q8WUR4 Q9HC15Explore the universe of human proteins at neXtProt for COMMD8: NX_Q9NX08
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NX08
COMMD8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060315.1
ENSEMBL proteins: ENSP00000370984
Human Recombinant Protein Products for COMMD8:
COMMD8 Antibody Products:
Assay Products for COMMD8: |
Protein
Domains /
Families
for COMMD8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
COMMD8 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NX08ProtoNet protein and cluster: Q9NX08 1 Blocks protein family: IPB009886 HCaRG
UniProtKB/Swiss-Prot: COMD8_HUMAN, Q9NX08Similarity: Contains 1 COMM domain |
Function
for COMMD8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
COMMD8 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for COMMD8:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD8 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD8
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: COMMD8 (NM_017845) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COMMD8 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COMMD8 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COMMD8 |
|
Pathways & Interactions
for COMMD8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for COMMD8
STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)
5/10 Interacting proteins for COMMD8 (Q9NX082, 3 ENSP000003709844) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
|
Drugs & Compounds
for COMMD8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for COMMD8
Search CenterWatch for drugs/clinical trials and news about COMMD8 / COMD8
|
Transcripts
for COMMD8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for COMMD8 gene: NM_017845.3 Unigene Cluster for COMMD8: COMM domain containing 8 Hs.23956 [show with all ESTs]Unigene Representative Sequence: BC0151452 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000381571(uc003gxi.3) ENST00000509220
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD8 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD8
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: COMMD8 (NM_017845) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COMMD8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COMMD8 |
Additional cDNA sequence: AF182421.1 AK000509.1 AY542163.1 BC008371.1 BC015145.1 BC019826.1 3 DOTS entries: DT.452534 DT.100816099 DT.100816097 24/213 AceView cDNA sequences (see all 213): CR594820 H99121 AA456810 BP338767 AA843682 BM712258 BU737725 BQ574055 N89657 BU631645 N38761 BU622666 BE218436 CB143540 AW273334 AA282144 AI381247 AI650715 CB990358 CR598833 N23057 BQ637397 BF195823 AW024149
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for COMMD8 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b |
|---|
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| SP1: | | | | | | | | | - | | - | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for COMMD8
|
Expression
for COMMD8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| COMMD8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTTTCTCAT
About this image
See COMMD8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for COMMD8
SOURCE GeneReport for Unigene cluster: Hs.23956
UniProtKB/Swiss-Prot: COMD8_HUMAN, Q9NX08Tissue specificity: Widely expressed with highest expression in thyroid
SABiosciences Custom PCR Arrays for COMMD8
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COMMD8
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat COMMD8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COMMD8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COMMD8 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COMMD8 |
Orthologs
for COMMD8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for COMMD8 gene from 6/17 species (see all 17) About this table
ENSEMBL Gene Tree for COMMD8 (if available)
TreeFam Gene Tree for COMMD8 (if available) |
Paralogs
for COMMD8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for COMMD8 gene
COMMD8 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for COMMD8
PGOHUM00000244418
|
Genomic Variants
for COMMD8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 4 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for COMMD8 (47452815 - 47465736 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for COMMD8
2 CNVs: 4392 92077 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COMMD8 |
|
Disorders
/ Diseases
for COMMD8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
COMMD8 for disorders About GeneDecksing
1  disease for COMMD8: About MalaCardsthyroiditis
Human Genome Epidemiology (HuGE) Navigator: COMMD8 (1 document)
Export disorders for COMMD8 gene to outside databases
|
Publications
for COMMD8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for COMMD8 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with COMMD8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- COMMD proteins, a novel family of structural and functional homologs of MURR1. (PubMed id 15799966)1, 2, 3 Burstein E....Duckett C.S. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
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External Searches for COMMD8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing COMMD8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing COMMD8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing COMMD8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for COMMD8 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for COMMD8 gene:
Search GeneIP for patents involving COMMD8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for COMMD8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for COMMD8 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COMMD8 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COMMD8 | | | OriGene Protein Over-expression Lysate for COMMD8 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for COMMD8 | | OriGene 3'-UTR Clone for COMMD8 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD8 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD8 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for COMMD8 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for COMMD8 | | OriGene Custom Protein Services for COMMD8 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat COMMD8 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COMMD8 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COMMD8 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COMMD8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COMMD8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COMMD8 |
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| | | | Search Tocris compounds for COMMD8 |
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 | | | COMMD8 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COMMD8 |
|  |  |  |  | | | | ThermoFisher Antibodies for COMMD8 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COMMD8 |
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