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Aliases for COMMD7 Gene

Aliases for COMMD7 Gene

  • COMM Domain Containing 7 2 3 5
  • C20orf92 3 4
  • Chromosome 20 Open Reading Frame 92 2
  • DJ1085F17.3 3

External Ids for COMMD7 Gene

Previous HGNC Symbols for COMMD7 Gene

  • C20orf92

Previous GeneCards Identifiers for COMMD7 Gene

  • GC20M032032
  • GC20M030754
  • GC20M031290
  • GC20M028079

Summaries for COMMD7 Gene

GeneCards Summary for COMMD7 Gene

COMMD7 (COMM Domain Containing 7) is a Protein Coding gene. GO annotations related to this gene include NF-kappaB binding.

UniProtKB/Swiss-Prot for COMMD7 Gene

  • May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Associates with the NF-kappa-B complex and suppresses its transcriptional activity (PubMed:15799966).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COMMD7 Gene

Genomics for COMMD7 Gene

Regulatory Elements for COMMD7 Gene

Enhancers for COMMD7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around COMMD7 on UCSC Golden Path with GeneCards custom track

Promoters for COMMD7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around COMMD7 on UCSC Golden Path with GeneCards custom track

Genomic Location for COMMD7 Gene

32,702,691 bp from pter
32,744,008 bp from pter
41,318 bases
Minus strand

Genomic View for COMMD7 Gene

Genes around COMMD7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COMMD7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COMMD7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COMMD7 Gene

Proteins for COMMD7 Gene

  • Protein details for COMMD7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    COMM domain-containing protein 7
    Protein Accession:
    Secondary Accessions:
    • A2BHJ2
    • B3KTZ2
    • Q5JYB0
    • Q96SI7
    • Q9BW53

    Protein attributes for COMMD7 Gene

    200 amino acids
    Molecular mass:
    22540 Da
    Quaternary structure:
    • Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with RELA. Interacts with CCDC22, CCDC93, SCNN1B, CUL7.

    Alternative splice isoforms for COMMD7 Gene


neXtProt entry for COMMD7 Gene

Proteomics data for COMMD7 Gene at MOPED

Post-translational modifications for COMMD7 Gene

  • Ubiquitination at Lys 73
  • Modification sites at PhosphoSitePlus

Other Protein References for COMMD7 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for COMMD7

No data available for DME Specific Peptides for COMMD7 Gene

Domains & Families for COMMD7 Gene

Gene Families for COMMD7 Gene

Protein Domains for COMMD7 Gene


Suggested Antigen Peptide Sequences for COMMD7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 COMM domain.
  • Contains 1 COMM domain.
genes like me logo Genes that share domains with COMMD7: view

Function for COMMD7 Gene

Molecular function for COMMD7 Gene

UniProtKB/Swiss-Prot Function:
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Associates with the NF-kappa-B complex and suppresses its transcriptional activity (PubMed:15799966).
genes like me logo Genes that share phenotypes with COMMD7: view

Animal Model Products

miRNA for COMMD7 Gene

miRTarBase miRNAs that target COMMD7

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COMMD7 Gene

Localization for COMMD7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COMMD7 Gene

Cytoplasmic vesicle.

Subcellular locations from

Jensen Localization Image for COMMD7 Gene COMPARTMENTS Subcellular localization image for COMMD7 gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for COMMD7 Gene

Pathways & Interactions for COMMD7 Gene

SuperPathways for COMMD7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for COMMD7 Gene


No data available for Pathways by source and SIGNOR curated interactions for COMMD7 Gene

Drugs & Compounds for COMMD7 Gene

No Compound Related Data Available

Transcripts for COMMD7 Gene

Unigene Clusters for COMMD7 Gene

COMM domain containing 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COMMD7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b
SP1: - -
SP3: - -
SP4: -

Relevant External Links for COMMD7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COMMD7 Gene

mRNA expression in normal human tissues for COMMD7 Gene

Protein differential expression in normal tissues from HIPED for COMMD7 Gene

This gene is overexpressed in Bone (18.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for COMMD7 Gene

SOURCE GeneReport for Unigene cluster for COMMD7 Gene Hs.408427

mRNA Expression by UniProt/SwissProt for COMMD7 Gene

Tissue specificity: Widely expressed with highest expression in lung.
genes like me logo Genes that share expression patterns with COMMD7: view

Protein tissue co-expression partners for COMMD7 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for COMMD7 Gene

Orthologs for COMMD7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for COMMD7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia COMMD7 35
  • 92.63 (n)
  • 94.47 (a)
  • 93 (a)
(Canis familiaris)
Mammalia COMMD7 35
  • 94.3 (n)
  • 95.98 (a)
  • 95 (a)
(Mus musculus)
Mammalia Commd7 35
  • 88.61 (n)
  • 88.44 (a)
Commd7 16
Commd7 36
  • 88 (a)
(Pan troglodytes)
Mammalia COMMD7 35
  • 99.83 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Commd7 35
  • 88.78 (n)
  • 91.46 (a)
(Monodelphis domestica)
Mammalia COMMD7 36
  • 80 (a)
(Gallus gallus)
Aves COMMD7 35
  • 74.67 (n)
  • 75.5 (a)
  • 74 (a)
(Anolis carolinensis)
Reptilia COMMD7 36
  • 69 (a)
(Danio rerio)
Actinopterygii commd7 35
  • 61.33 (n)
  • 62 (a)
commd7 36
  • 59 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6641 36
  • 34 (a)
Species with no ortholog for COMMD7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COMMD7 Gene

Gene Tree for COMMD7 (if available)
Gene Tree for COMMD7 (if available)

Paralogs for COMMD7 Gene

No data available for Paralogs for COMMD7 Gene

Variants for COMMD7 Gene

Sequence variations from dbSNP and Humsavar for COMMD7 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs9421 -- 32,703,359(+) GGGGC(C/G/T)AGGGG downstream-variant-500B, utr-variant-3-prime
rs2013712 -- 32,745,332(-) CACGG(G/T)GAGTA upstream-variant-2KB
rs2064933 -- 32,726,818(+) GGAAT(A/G)TTCTG intron-variant
rs2064934 -- 32,726,950(+) CTGAA(C/G)ctggg intron-variant
rs2064935 -- 32,727,133(+) gaggc(A/G)ggagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COMMD7 Gene

Variant ID Type Subtype PubMed ID
nsv833956 CNV Loss 17160897
esv994647 CNV Deletion 20482838
esv2552132 CNV Deletion 19546169
nsv512610 CNV Loss 21212237
esv2656560 CNV Deletion 23128226
esv2659067 CNV Deletion 23128226
nsv512611 CNV Loss 21212237
esv2722345 CNV Deletion 23290073
esv2665382 CNV Deletion 23128226

Variation tolerance for COMMD7 Gene

Residual Variation Intolerance Score: 49.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.83% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for COMMD7 Gene

Disorders for COMMD7 Gene

Relevant External Links for COMMD7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for COMMD7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COMMD7 Gene

Publications for COMMD7 Gene

  1. COMMD proteins, a novel family of structural and functional homologs of MURR1. (PMID: 15799966) Burstein E. … Duckett C.S. (J. Biol. Chem. 2005) 2 3 4 67
  2. COMMD7 as a novel NEMO interacting protein involved in the termination of NF-I_B signaling. (PMID: 26060140) Esposito E. … Ursini M.V. (J. Cell. Physiol. 2016) 3
  3. COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A. (PMID: 25355947) Phillips-Krawczak C.A. … Burstein E. (Mol. Biol. Cell 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for COMMD7 Gene

Sources for COMMD7 Gene