COMMD7 Gene
protein-coding GIFtS: 46
GCID: GC20M031290
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COMM domain containing 7(Previous name: chromosome 20 open reading frame 92 )
(Previous symbol: C20orf92)
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Aliases
for COMMD7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| COMM Domain Containing 71 2 | | C20orf921 2 3 | | DJ1085F17.31 | | Chromosome 20 Open Reading Frame 921 | | COMM Domain-Containing Protein 72 |
Export aliases for COMMD7 gene to outside databasesPrevious GC identifers: GC20M032032 GC20M030754 GC20M028079 |
Summaries
for COMMD7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: COMD7_HUMAN, Q86VX2Function: Associates with the NF-kappa-B complex and suppresses its transcriptional activity
|
Genomic Views
for COMMD7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011362.10
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the COMMD7 gene promoter:
N-Myc Cart-1 FOXD3 Lmo2 MyoD Pax-4a GATA-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for COMMD7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COMMD7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q11.21 Ensembl cytogenetic band: 20q11.21 HGNC cytogenetic band: 20q11COMMD7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M031290: view genomic region
(about GC identifiers)
Start:
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31,290,493 bp from pter |
End:
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31,331,814 bp from pter |
Size:
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41,322 bases |
Orientation:
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minus strand |
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Proteins
for COMMD7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: COMD7_HUMAN, Q86VX2 (See
protein sequence)Recommended Name: COMM domain-containing protein 7 Size: 200 amino acids; 22540 Da
Subunit: Interacts (via COMM domain) with COMMD1 (via COMM domain)
Secondary accessions: A2BHJ2 B3KTZ2 Q5JYB0 Q96SI7 Q9BW53Alternative splicing: 2 isoforms: Q86VX2-1 Q86VX2-2 Explore the universe of human proteins at neXtProt for COMMD7: NX_Q86VX2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86VX2
COMMD7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001092809.1 NP_444269.2
ENSEMBL proteins: ENSP00000278980 ENSP00000395339
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
COMMD7 for ontologies About GeneDecksing
COMMD7 Antibody Products:
Assay Products for COMMD7: |
Protein
Domains /
Families
for COMMD7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
COMMD7 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86VX2ProtoNet protein and cluster: Q86VX2 1 Blocks protein family: IPB009886 HCaRG
UniProtKB/Swiss-Prot: COMD7_HUMAN, Q86VX2Similarity: Contains 1 COMM domain |
Function
for COMMD7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: COMD7_HUMAN, Q86VX2Function: Associates with the NF-kappa-B complex and suppresses its transcriptional activity
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD7 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD7 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): COMMD7 (NM_053041) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COMMD7 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COMMD7 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COMMD7 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
COMMD7 for ontologies About GeneDecksing
|
Pathways & Interactions
for COMMD7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for COMMD7
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for COMMD7 (Q86VX23 ENSP000002789804) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
COMMD7 for ontologies About GeneDecksing
|
Drugs & Compounds
for COMMD7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for COMMD7
Search CenterWatch for drugs/clinical trials and news about COMMD7 / COMD7
|
Transcripts
for COMMD7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for COMMD7 gene (2 alternative transcripts): NM_001099339.1 NM_053041.2 Unigene Cluster for COMMD7: COMM domain containing 7 Hs.408427 [show with all ESTs]Unigene Representative Sequence: NM_0530413 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000278980 ENST00000474815 ENST00000446419(uc002wya.4 uc010ged.3 uc002wyb.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD7 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD7 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): COMMD7 (NM_053041) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COMMD7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COMMD7 |
Additional cDNA sequence: AK027893.1 AK096307.1 AY542162.1 BC000628.2 BC047440.1 10 DOTS entries: DT.448561 DT.100787600 DT.70100033 DT.100834755 DT.120832033 DT.91748102 DT.100028607 DT.100735576 DT.91748109 DT.95072944 24/282 AceView cDNA sequences (see all 282): BF197344 AI253248 AI686187 CB163383 AI269680 BE766456 BU683487 BF196077 BE503344 AI221209 CB321821 BM972184 AI669829 AA804389 BQ007407 AW593493 CA445159 BM990627 BU948281 BU526688 BE671983 CK824979 AK097059 BM820354
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for COMMD7 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b |
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| SP1: | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | |
| SP4: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for COMMD7
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Expression
for COMMD7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| COMMD7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCGTAACGAG
About this image
See COMMD7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for COMMD7
SOURCE GeneReport for Unigene cluster: Hs.408427
UniProtKB/Swiss-Prot: COMD7_HUMAN, Q86VX2Tissue specificity: Widely expressed with highest expression in lung
SABiosciences Custom PCR Arrays for COMMD7
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COMMD7
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat COMMD7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COMMD7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COMMD7 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COMMD7 |
Orthologs
for COMMD7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for COMMD7 gene from 4/15 species (see all 15) About this table
ENSEMBL Gene Tree for COMMD7 (if available)
TreeFam Gene Tree for COMMD7 (if available) |
Paralogs
for COMMD7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for COMMD7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for COMMD7 (31290493 - 31331814 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for COMMD7
4 CNVs: 102953 79176 90537 79175 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COMMD7 |
|
Disorders
/ Diseases
for COMMD7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 COMMD7 for disorders About MalaCards
COMMD7 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: COMMD7 (1 document)
Export disorders for COMMD7 gene to outside databases
|
Publications
for COMMD7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for COMMD7 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with COMMD7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- COMMD proteins, a novel family of structural and functional homologs of MURR1. (PubMed id 15799966)1, 2, 3 Burstein E....Duckett C.S. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Expression of BC047440 protein in hepatocellular carc inoma and its relationship to prognosis. (PubMed id 20979692)1 Zheng L....Feng H. (2010)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for COMMD7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing COMMD7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing COMMD7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing COMMD7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for COMMD7 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for COMMD7 gene:
Search GeneIP for patents involving COMMD7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for COMMD7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for COMMD7 | | OriGene shRNA RFP for COMMD7 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COMMD7 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COMMD7 | | | OriGene Protein Over-expression Lysate for COMMD7 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for COMMD7 | | OriGene 3'-UTR Clone for COMMD7 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD7 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD7 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for COMMD7 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for COMMD7 | | OriGene Custom Protein Services for COMMD7 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat COMMD7 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COMMD7 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COMMD7 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COMMD7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COMMD7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COMMD7 |
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| | | | Search Tocris compounds for COMMD7 |
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 | | | COMMD7 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COMMD7 |
|  |  |  | | | | ThermoFisher Antibodies for COMMD7 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COMMD7 |
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