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Aliases for COMMD7 Gene

Aliases for COMMD7 Gene

  • COMM Domain Containing 7 2 3
  • C20orf92 3 4
  • Chromosome 20 Open Reading Frame 92 2
  • COMM Domain-Containing Protein 7 3
  • DJ1085F17.3 3

External Ids for COMMD7 Gene

Previous HGNC Symbols for COMMD7 Gene

  • C20orf92

Previous GeneCards Identifiers for COMMD7 Gene

  • GC20M032032
  • GC20M030754
  • GC20M031290
  • GC20M028079

Summaries for COMMD7 Gene

GeneCards Summary for COMMD7 Gene

COMMD7 (COMM Domain Containing 7) is a Protein Coding gene. GO annotations related to this gene include NF-kappaB binding.

UniProtKB/Swiss-Prot for COMMD7 Gene

  • May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Associates with the NF-kappa-B complex and suppresses its transcriptional activity (PubMed:15799966).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COMMD7 Gene

Genomics for COMMD7 Gene

Regulatory Elements for COMMD7 Gene

Genomic Location for COMMD7 Gene

32,702,691 bp from pter
32,744,008 bp from pter
41,318 bases
Minus strand

Genomic View for COMMD7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COMMD7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COMMD7 Gene

Proteins for COMMD7 Gene

  • Protein details for COMMD7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    COMM domain-containing protein 7
    Protein Accession:
    Secondary Accessions:
    • A2BHJ2
    • B3KTZ2
    • Q5JYB0
    • Q96SI7
    • Q9BW53

    Protein attributes for COMMD7 Gene

    200 amino acids
    Molecular mass:
    22540 Da
    Quaternary structure:
    • Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with RELA. Interacts with CCDC22, CCDC93, SCNN1B, CUL7.

    Alternative splice isoforms for COMMD7 Gene


neXtProt entry for COMMD7 Gene

Proteomics data for COMMD7 Gene at MOPED

Post-translational modifications for COMMD7 Gene

  • Ubiquitination at Lys73
  • Modification sites at PhosphoSitePlus

Other Protein References for COMMD7 Gene

No data available for DME Specific Peptides for COMMD7 Gene

Domains for COMMD7 Gene

Protein Domains for COMMD7 Gene


Suggested Antigen Peptide Sequences for COMMD7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q86VX2
  • Contains 1 COMM domain.
genes like me logo Genes that share domains with COMMD7: view

No data available for Gene Families for COMMD7 Gene

Function for COMMD7 Gene

Molecular function for COMMD7 Gene

UniProtKB/Swiss-Prot Function: May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Associates with the NF-kappa-B complex and suppresses its transcriptional activity (PubMed:15799966).

Gene Ontology (GO) - Molecular Function for COMMD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15799966
GO:0051059 NF-kappaB binding IDA 15799966
genes like me logo Genes that share ontologies with COMMD7: view

miRNA for COMMD7 Gene

miRTarBase miRNAs that target COMMD7

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for COMMD7 Gene

Localization for COMMD7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COMMD7 Gene

Cytoplasmic vesicle.

Subcellular locations from

Jensen Localization Image for COMMD7 Gene COMPARTMENTS Subcellular localization image for COMMD7 gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for COMMD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016023 cytoplasmic membrane-bounded vesicle IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with COMMD7: view

Pathways for COMMD7 Gene

SuperPathways for COMMD7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for COMMD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0032088 negative regulation of NF-kappaB transcription factor activity IDA 15799966
GO:0033209 tumor necrosis factor-mediated signaling pathway IDA 15799966
GO:0045892 negative regulation of transcription, DNA-templated IDA 15799966
genes like me logo Genes that share ontologies with COMMD7: view

No data available for Pathways by source for COMMD7 Gene

Transcripts for COMMD7 Gene

Unigene Clusters for COMMD7 Gene

COMM domain containing 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COMMD7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b
SP1: - -
SP3: - -
SP4: -

Relevant External Links for COMMD7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COMMD7 Gene

mRNA expression in normal human tissues for COMMD7 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COMMD7 Gene

SOURCE GeneReport for Unigene cluster for COMMD7 Gene Hs.408427

mRNA Expression by UniProt/SwissProt for COMMD7 Gene

Tissue specificity: Widely expressed with highest expression in lung.
genes like me logo Genes that share expressions with COMMD7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for COMMD7 Gene

Orthologs for COMMD7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for COMMD7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia COMMD7 35
  • 99.83 (n)
  • 100 (a)
  • 100 (a)
(Bos Taurus)
Mammalia COMMD7 35
  • 92.63 (n)
  • 94.47 (a)
  • 93 (a)
(Canis familiaris)
Mammalia COMMD7 35
  • 94.3 (n)
  • 95.98 (a)
  • 95 (a)
(Mus musculus)
Mammalia Commd7 35
  • 88.61 (n)
  • 88.44 (a)
Commd7 16
Commd7 36
  • 88 (a)
(Monodelphis domestica)
Mammalia COMMD7 36
  • 80 (a)
(Rattus norvegicus)
Mammalia Commd7 35
  • 88.78 (n)
  • 91.46 (a)
(Gallus gallus)
Aves COMMD7 35
  • 74.67 (n)
  • 75.5 (a)
  • 74 (a)
(Anolis carolinensis)
Reptilia COMMD7 36
  • 69 (a)
(Danio rerio)
Actinopterygii commd7 35
  • 61.33 (n)
  • 62 (a)
commd7 36
  • 59 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6641 36
  • 34 (a)
Species with no ortholog for COMMD7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COMMD7 Gene

Gene Tree for COMMD7 (if available)
Gene Tree for COMMD7 (if available)

Paralogs for COMMD7 Gene

No data available for Paralogs for COMMD7 Gene

Variants for COMMD7 Gene

Sequence variations from dbSNP and Humsavar for COMMD7 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs9421 -- 32,703,359(+) GGGGC(C/G/T)AGGGG utr-variant-3-prime
rs2013712 -- 32,745,332(-) CACGG(G/T)GAGTA upstream-variant-2KB
rs2064933 -- 32,726,818(+) GGAAT(A/G)TTCTG intron-variant
rs2064934 -- 32,726,950(+) CTGAA(C/G)ctggg intron-variant
rs2064935 -- 32,727,133(+) gaggc(A/G)ggagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COMMD7 Gene

Variant ID Type Subtype PubMed ID
nsv833956 CNV Loss 17160897
esv994647 CNV Deletion 20482838
esv2552132 CNV Deletion 19546169
nsv512610 CNV Loss 21212237
esv2656560 CNV Deletion 23128226
esv2659067 CNV Deletion 23128226
nsv512611 CNV Loss 21212237
esv2722345 CNV Deletion 23290073
esv2665382 CNV Deletion 23128226

Relevant External Links for COMMD7 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COMMD7 Gene

Disorders for COMMD7 Gene

Relevant External Links for COMMD7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with COMMD7: view

No data available for UniProtKB/Swiss-Prot for COMMD7 Gene

Publications for COMMD7 Gene

  1. COMMD proteins, a novel family of structural and functional homologs of MURR1. (PMID: 15799966) Burstein E. … Duckett C.S. (J. Biol. Chem. 2005) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for COMMD7 Gene

  • antibodies-online proteins for COMMD7
  • antibodies-online antibodies for COMMD7
  • antibodies-online kits for COMMD7

Sources for COMMD7 Gene

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