Free for academic non-profit institutions. Other users need a Commercial license

Aliases for COMMD6 Gene

Aliases for COMMD6 Gene

  • COMM Domain Containing 6 2 3 5
  • Acrg Embryonic Lethality Minimal Region Ortholog 3
  • Acrg 3

External Ids for COMMD6 Gene

Previous GeneCards Identifiers for COMMD6 Gene

  • GC13M073897
  • GC13M074998
  • GC13M076099
  • GC13M056796

Summaries for COMMD6 Gene

Entrez Gene Summary for COMMD6 Gene

  • COMMD6 belongs to a family of NF-kappa-B (see RELA; MIM 164014)-inhibiting proteins characterized by the presence of a COMM domain (see COMMD1; MIM 607238) (de Bie et al., 2006 [PubMed 16573520]).[supplied by OMIM, Mar 2009]

GeneCards Summary for COMMD6 Gene

COMMD6 (COMM Domain Containing 6) is a Protein Coding gene. GO annotations related to this gene include NF-kappaB binding.

UniProtKB/Swiss-Prot for COMMD6 Gene

  • May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Down-regulates activation of NF-kappa-B. Inhibits TNF-induced NFKB1 activation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COMMD6 Gene

Genomics for COMMD6 Gene

Regulatory Elements for COMMD6 Gene

Enhancers for COMMD6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around COMMD6 on UCSC Golden Path with GeneCards custom track

Promoters for COMMD6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around COMMD6 on UCSC Golden Path with GeneCards custom track

Genomic Location for COMMD6 Gene

75,525,214 bp from pter
75,549,439 bp from pter
24,226 bases
Minus strand

Genomic View for COMMD6 Gene

Genes around COMMD6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COMMD6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COMMD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COMMD6 Gene

Proteins for COMMD6 Gene

  • Protein details for COMMD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    COMM domain-containing protein 6
    Protein Accession:
    Secondary Accessions:
    • A6NF28
    • B7ZLN0
    • Q5TBK4

    Protein attributes for COMMD6 Gene

    85 amino acids
    Molecular mass:
    9638 Da
    Quaternary structure:
    • Homodimer. Can only homodimerize with isoform 1. Interacts directly with COMMD1 (via COMM domain). Interacts with RELA, RELB, NFKB1/p105. Does not interact with NFKBIB. Interacts with CCDC22, CCDC93, SCNN1B, CUL4A.

    Alternative splice isoforms for COMMD6 Gene


neXtProt entry for COMMD6 Gene

Proteomics data for COMMD6 Gene at MOPED

Post-translational modifications for COMMD6 Gene

  • Ubiquitination at Lys 39
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for COMMD6 Gene

Domains & Families for COMMD6 Gene

Gene Families for COMMD6 Gene

Protein Domains for COMMD6 Gene


Suggested Antigen Peptide Sequences for COMMD6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 COMM domain.
  • Contains 1 COMM domain.
genes like me logo Genes that share domains with COMMD6: view

Function for COMMD6 Gene

Molecular function for COMMD6 Gene

UniProtKB/Swiss-Prot Function:
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Down-regulates activation of NF-kappa-B. Inhibits TNF-induced NFKB1 activation.

Phenotypes for COMMD6 Gene

genes like me logo Genes that share phenotypes with COMMD6: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COMMD6 Gene

Localization for COMMD6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COMMD6 Gene

Nucleus. Cytoplasm.

Subcellular locations from

Jensen Localization Image for COMMD6 Gene COMPARTMENTS Subcellular localization image for COMMD6 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for COMMD6 Gene

Pathways & Interactions for COMMD6 Gene

SuperPathways for COMMD6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for COMMD6 Gene


No data available for Pathways by source and SIGNOR curated interactions for COMMD6 Gene

Drugs & Compounds for COMMD6 Gene

No Compound Related Data Available

Transcripts for COMMD6 Gene

Unigene Clusters for COMMD6 Gene

COMM domain containing 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COMMD6 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4
SP1: - - -
SP4: - -

Relevant External Links for COMMD6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COMMD6 Gene

mRNA expression in normal human tissues for COMMD6 Gene

Protein differential expression in normal tissues from HIPED for COMMD6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.8), Bone marrow stromal cell (10.4), and Breast (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for COMMD6 Gene

SOURCE GeneReport for Unigene cluster for COMMD6 Gene Hs.508266

mRNA Expression by UniProt/SwissProt for COMMD6 Gene

Tissue specificity: Ubiquitous. Expressed in brain, heart, skeletal muscle, lung, pancreas, liver, kidney, small intestine and placenta.
genes like me logo Genes that share expression patterns with COMMD6: view

Protein tissue co-expression partners for COMMD6 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for COMMD6 Gene

Orthologs for COMMD6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for COMMD6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia COMMD6 36
  • 87 (a)
(Canis familiaris)
Mammalia COMMD6 36
  • 60 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
-- 36
  • 72 (a)
-- 36
  • 72 (a)
-- 36
  • 74 (a)
(Mus musculus)
Mammalia Commd6 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia COMMD6 36
  • 75 (a)
(Pan troglodytes)
Mammalia COMMD6 36
  • 98 (a)
(Gallus gallus)
Aves COMMD6 36
  • 25 (a)
(Anolis carolinensis)
Reptilia COMMD6 36
  • 23 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6964 35
(Danio rerio)
Actinopterygii COMMD6 36
  • 26 (a)
Species with no ortholog for COMMD6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COMMD6 Gene

Gene Tree for COMMD6 (if available)
Gene Tree for COMMD6 (if available)

Paralogs for COMMD6 Gene Pseudogenes for COMMD6 Gene

genes like me logo Genes that share paralogs with COMMD6: view

No data available for Paralogs for COMMD6 Gene

Variants for COMMD6 Gene

Sequence variations from dbSNP and Humsavar for COMMD6 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1063485 - 75,530,167(-) CAGAT(A/C)ATTCA reference, missense
rs768261 -- 75,524,832(+) AACTA(G/T)ACATT downstream-variant-500B
rs1041007 -- 75,532,010(+) cttca(A/G)ttaca intron-variant
rs1050235 -- 75,526,503(-) GAACA(C/T)TTATT utr-variant-3-prime
rs1408042 -- 75,527,727(+) ggaca(C/T)tgtgc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COMMD6 Gene

Variant ID Type Subtype PubMed ID
nsv521444 CNV Gain 19592680
nsv900562 CNV Loss 21882294
dgv1692n71 CNV Loss 21882294
esv32759 CNV Loss 17666407
nsv1089 CNV Insertion 18451855
esv23690 CNV Gain 19812545
esv2596575 CNV Gain 19546169
nsv442676 CNV CNV 18776908
nsv514711 CNV Gain 21397061
esv2421984 CNV Duplication 20811451
nsv525594 CNV Gain 19592680
nsv818980 CNV Gain 17921354

Variation tolerance for COMMD6 Gene

Residual Variation Intolerance Score: 43.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.20; 4.57% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for COMMD6 Gene

Disorders for COMMD6 Gene

Relevant External Links for COMMD6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for COMMD6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COMMD6 Gene

Publications for COMMD6 Gene

  1. COMMD proteins, a novel family of structural and functional homologs of MURR1. (PMID: 15799966) Burstein E. … Duckett C.S. (J. Biol. Chem. 2005) 2 3 4 67
  2. COMMD7 as a novel NEMO interacting protein involved in the termination of NF-I_B signaling. (PMID: 26060140) Esposito E. … Ursini M.V. (J. Cell. Physiol. 2016) 3
  3. COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A. (PMID: 25355947) Phillips-Krawczak C.A. … Burstein E. (Mol. Biol. Cell 2015) 3
  4. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for COMMD6 Gene

Sources for COMMD6 Gene