COMMD6 Gene
protein-coding GIFtS: 44
GCID: GC13M076099
|
|
COMM domain containing 6
| |
Aliases
for COMMD6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| COMM Domain Containing 61 2 | | Acrg1 2 | | Acrg Embryonic Lethality Minimal Region Ortholog2 | | COMM Domain-Containing Protein 62 |
Export aliases for COMMD6 gene to outside databasesPrevious GC identifers: GC13M073897 GC13M074998 GC13M056796 |
Summaries
for COMMD6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for COMMD6:
COMMD6 belongs to a family of NF-kappa-B (see RELA; MIM 164014)-inhibiting proteins characterized by the presence of aCOMM domain (see COMMD1; MIM 607238) (de Bie et al., 2006 (PubMed 16573520)).(supplied by OMIM, Mar 2009)
UniProtKB/Swiss-Prot: COMD6_HUMAN, Q7Z4G1Function: Down-regulates activation of NF-kappa-B. Inhibits TNF-induced NFKB1 activation
|
Genomic Views
for COMMD6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_024524.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the COMMD6 gene promoter:
HOXA9 HOXA9B S8 Elk-1 p53 Meis-1a Meis-1 Meis-1b
Other transcription factors
Search SABiosciences Chromatin IP Primers for COMMD6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COMMD6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q22 Ensembl cytogenetic band: 13q22.2 HGNC cytogenetic band: 13q22COMMD6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13M076099: view genomic region
(about GC identifiers)
Start:
|
76,099,350 bp from pter |
End:
|
76,123,575 bp from pter |
Size:
|
24,226 bases |
Orientation:
|
minus strand |
|
Proteins
for COMMD6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: COMD6_HUMAN, Q7Z4G1 (See
protein sequence)Recommended Name: COMM domain-containing protein 6 Size: 85 amino acids; 9638 Da
Subunit: Homodimer. Can only homodimerize with isoform 1. Interacts directly with COMMD1 (via COMM domain). Does notinteract with NFKBIB
Subcellular location: Nucleus. Cytoplasm
Secondary accessions: A6NF28 B7ZLN0 Q5TBK4Alternative splicing: 2 isoforms: Q7Z4G1-1 Q7Z4G1-2 Explore the universe of human proteins at neXtProt for COMMD6: NX_Q7Z4G1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7Z4G1
COMMD6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_987091.1 NP_987093.1
ENSEMBL proteins: ENSP00000366841 ENSP00000366845 ENSP00000348054 ENSP00000366838 ENSP00000385660
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
COMMD6 for ontologies About GeneDecksing
COMMD6 Antibody Products:
Assay Products for COMMD6: |
Protein
Domains /
Families
for COMMD6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
COMMD6 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q7Z4G1ProtoNet protein and cluster: Q7Z4G1 1 Blocks protein family: IPB009886 HCaRG
UniProtKB/Swiss-Prot: COMD6_HUMAN, Q7Z4G1Similarity: Contains 1 COMM domain |
Function
for COMMD6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: COMD6_HUMAN, Q7Z4G1Function: Down-regulates activation of NF-kappa-B. Inhibits TNF-induced NFKB1 activation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD6 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD6 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for COMMD6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COMMD6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COMMD6 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
COMMD6 for ontologies About GeneDecksing
|
Pathways & Interactions
for COMMD6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for COMMD6
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for COMMD6 (Q7Z4G11, 3 ENSP000003480544) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0032088 | negative regulation of NF-kappaB transcription factor activity |
IDA | 16573520 |
COMMD6 for ontologies About GeneDecksing
|
Drugs & Compounds
for COMMD6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for COMMD6
Search CenterWatch for drugs/clinical trials and news about COMMD6 / COMD6
|
Transcripts
for COMMD6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for COMMD6 gene (2 alternative transcripts): NM_203495.2 NM_203497.2 Unigene Cluster for COMMD6: COMM domain containing 6 Hs.508266 [show with all ESTs]Unigene Representative Sequence: NM_20349712 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000377615 ENST00000483290 ENST00000377619 ENST00000486516 ENST00000497707
ENST00000355801 ENST00000377612 ENST00000460675 ENST00000464050 ENST00000477377
ENST00000471682 ENST00000406936(uc001vjn.1 uc001vjo.1 uc010aet.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD6 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD6 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): COMMD6 (NM_203497) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COMMD6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COMMD6 |
Additional cDNA sequence: AF086081.1 AF169971.1 AK000009.1 AY542161.1 BC110837.1 BC117391.1 BC143912.1 BC171758.1 BX538116.1 13 DOTS entries: DT.100698015 DT.100782953 DT.454156 DT.101984781 DT.95167932 DT.100037216 DT.95167940 DT.99978770 DT.86855061 DT.95138276 DT.100820919 DT.435165 DT.97850525 24/212 AceView cDNA sequences (see all 212): AA719970 AA613470 AI720815 AA569817 AA972340 BX538116 T35137 AW516275 AA832507 AA906305 CR603325 AA026062 AI282084 AA425275 AA569802 AI857470 AI202057 AI245881 AA055007 AF086081 AI272750 BM054739 AI566668 AI129807
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for COMMD6 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | ^ | 4 |
|---|
|
| SP1: | | | | | | | - | | - | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | | | | |
ECgene alternative splicing isoforms for COMMD6
|
Expression
for COMMD6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| COMMD6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACTTCACTT
About this image
See COMMD6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for COMMD6
SOURCE GeneReport for Unigene cluster: Hs.508266
UniProtKB/Swiss-Prot: COMD6_HUMAN, Q7Z4G1Tissue specificity: Ubiquitous. Expressed in brain, heart, skeletal muscle, lung, pancreas, liver, kidney, smallintestine and placenta
SABiosciences Custom PCR Arrays for COMMD6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COMMD6
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COMMD6 |
Orthologs
for COMMD6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for COMMD6 gene from 5/12 species (see all 12) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Commd65 |
COMM domain containing 6 |
-- |
|
14 (50.90 cM) 101633766 |
chicken
(Gallus gallus) |
Aves |
COMMD66 |
Uncharacterized protein |
27(a) |
1 ↔ 1 |
1(159150699-159155948) |
lizard
(Anolis carolinensis) |
Reptilia |
COMMD66 |
-- |
67(a) |
1 ↔ 1 |
3(87356876-87361197) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.69642 |
Xenopus laevis transcribed sequences |
74.61(n) |
|
BJ069761.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
si:ch211-222g23.36 |
si:ch211-222g23.3 |
25(a) |
1 ↔ 1 |
9(31611233-31615544) |
ENSEMBL Gene Tree for COMMD6 (if available)
TreeFam Gene Tree for COMMD6 (if available) |
Paralogs
for COMMD6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for COMMD6 gene
COMMD6 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for COMMD6
PGOHUM00000244311
|
Genomic Variants
for COMMD6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for COMMD6 (76099350 - 76123575 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 13 variations for COMMD6
12 CNVs: 86912 76418 86913 101780 76420 9716 37791 35183 66483 35182 76417 76419
1 Indel: 11080 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COMMD6 |
|
Disorders
/ Diseases
for COMMD6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
COMMD6 for disorders About GeneDecksing
OMIM gene information: 612377
OMIM disorders: --
1  disease for COMMD6: About MalaCardspseudopseudohypoparathyroidism
Export disorders for COMMD6 gene to outside databases
|
Publications
for COMMD6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for COMMD6 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with COMMD6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- COMMD proteins, a novel family of structural and functional homologs of MURR1. (PubMed id 15799966)1, 2, 3 Burstein E....Duckett C.S. (2005)
- Characterization of COMMD protein-protein interactions in NF-kappaB signalling. (PubMed id 16573520)1, 2 de Bie P.... Klomp L.W. (2006)
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for COMMD6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing COMMD6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing COMMD6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing COMMD6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for COMMD6 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for COMMD6 gene:
Search GeneIP for patents involving COMMD6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for COMMD6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for COMMD6 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COMMD6 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COMMD6 | | | OriGene Protein Over-expression Lysate for COMMD6 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for COMMD6 | | OriGene 3'-UTR Clone for COMMD6 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD6 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD6 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for COMMD6 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat COMMD6 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COMMD6 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COMMD6 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COMMD6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COMMD6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COMMD6 |
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| |  |  |  |  | | | | |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COMMD6 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COMMD6 |
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