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Aliases for COMMD6 Gene

Aliases for COMMD6 Gene

  • COMM Domain Containing 6 2 3
  • Acrg Embryonic Lethality Minimal Region Ortholog 3
  • COMM Domain-Containing Protein 6 3
  • Acrg 3

External Ids for COMMD6 Gene

Previous GeneCards Identifiers for COMMD6 Gene

  • GC13M073897
  • GC13M074998
  • GC13M076099
  • GC13M056796

Summaries for COMMD6 Gene

Entrez Gene Summary for COMMD6 Gene

  • COMMD6 belongs to a family of NF-kappa-B (see RELA; MIM 164014)-inhibiting proteins characterized by the presence of a COMM domain (see COMMD1; MIM 607238) (de Bie et al., 2006 [PubMed 16573520]).[supplied by OMIM, Mar 2009]

GeneCards Summary for COMMD6 Gene

COMMD6 (COMM Domain Containing 6) is a Protein Coding gene. GO annotations related to this gene include NF-kappaB binding.

UniProtKB/Swiss-Prot for COMMD6 Gene

  • May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Down-regulates activation of NF-kappa-B. Inhibits TNF-induced NFKB1 activation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COMMD6 Gene

Genomics for COMMD6 Gene

Regulatory Elements for COMMD6 Gene

Genomic Location for COMMD6 Gene

Start:
75,525,214 bp from pter
End:
75,549,439 bp from pter
Size:
24,226 bases
Orientation:
Minus strand

Genomic View for COMMD6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COMMD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COMMD6 Gene

Proteins for COMMD6 Gene

  • Protein details for COMMD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z4G1-COMD6_HUMAN
    Recommended name:
    COMM domain-containing protein 6
    Protein Accession:
    Q7Z4G1
    Secondary Accessions:
    • A6NF28
    • B7ZLN0
    • Q5TBK4

    Protein attributes for COMMD6 Gene

    Size:
    85 amino acids
    Molecular mass:
    9638 Da
    Quaternary structure:
    • Homodimer. Can only homodimerize with isoform 1. Interacts directly with COMMD1 (via COMM domain). Interacts with RELA, RELB, NFKB1/p105. Does not interact with NFKBIB. Interacts with CCDC22, CCDC93, SCNN1B, CUL4A.

    Alternative splice isoforms for COMMD6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COMMD6 Gene

Proteomics data for COMMD6 Gene at MOPED

Post-translational modifications for COMMD6 Gene

  • Ubiquitination at Lys39
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for COMMD6 Gene

Domains for COMMD6 Gene

Protein Domains for COMMD6 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for COMMD6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z4G1

UniProtKB/Swiss-Prot:

COMD6_HUMAN :
  • Q7Z4G1
Domain:
  • Contains 1 COMM domain.
genes like me logo Genes that share domains with COMMD6: view

No data available for Gene Families for COMMD6 Gene

Function for COMMD6 Gene

Molecular function for COMMD6 Gene

UniProtKB/Swiss-Prot Function: May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Down-regulates activation of NF-kappa-B. Inhibits TNF-induced NFKB1 activation.

Gene Ontology (GO) - Molecular Function for COMMD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15799966
GO:0051059 NF-kappaB binding IPI 16573520
genes like me logo Genes that share ontologies with COMMD6: view

miRNA for COMMD6 Gene

miRTarBase miRNAs that target COMMD6

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for COMMD6 Gene

Localization for COMMD6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COMMD6 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COMMD6 Gene COMPARTMENTS Subcellular localization image for COMMD6 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for COMMD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with COMMD6: view

Pathways for COMMD6 Gene

SuperPathways for COMMD6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for COMMD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0032088 negative regulation of NF-kappaB transcription factor activity IDA 16573520
genes like me logo Genes that share ontologies with COMMD6: view

No data available for Pathways by source for COMMD6 Gene

Transcripts for COMMD6 Gene

Unigene Clusters for COMMD6 Gene

COMM domain containing 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COMMD6 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4
SP1: - - -
SP2:
SP3:
SP4: - -

Relevant External Links for COMMD6 Gene

GeneLoc Exon Structure for
COMMD6
ECgene alternative splicing isoforms for
COMMD6

Expression for COMMD6 Gene

mRNA expression in normal human tissues for COMMD6 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COMMD6 Gene

SOURCE GeneReport for Unigene cluster for COMMD6 Gene Hs.508266

mRNA Expression by UniProt/SwissProt for COMMD6 Gene

Q7Z4G1-COMD6_HUMAN
Tissue specificity: Ubiquitous. Expressed in brain, heart, skeletal muscle, lung, pancreas, liver, kidney, small intestine and placenta.
genes like me logo Genes that share expressions with COMMD6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for COMMD6 Gene

Orthologs for COMMD6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for COMMD6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COMMD6 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia COMMD6 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COMMD6 36
  • 60 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Commd6 16
Commd6 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
OneToMany
-- 36
  • 72 (a)
OneToMany
-- 36
  • 72 (a)
OneToMany
-- 36
  • 74 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia COMMD6 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves COMMD6 36
  • 25 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COMMD6 36
  • 23 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6964 35
zebrafish
(Danio rerio)
Actinopterygii COMMD6 36
  • 26 (a)
OneToOne
Species with no ortholog for COMMD6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COMMD6 Gene

ENSEMBL:
Gene Tree for COMMD6 (if available)
TreeFam:
Gene Tree for COMMD6 (if available)

Paralogs for COMMD6 Gene

Pseudogenes.org Pseudogenes for COMMD6 Gene

genes like me logo Genes that share paralogs with COMMD6: view

No data available for Paralogs for COMMD6 Gene

Variants for COMMD6 Gene

Sequence variations from dbSNP and Humsavar for COMMD6 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs768261 -- 75,524,832(+) AACTA(G/T)ACATT downstream-variant-500B
rs1041007 -- 75,532,010(+) cttca(A/G)ttaca intron-variant
rs1050235 -- 75,526,503(-) GAACA(C/T)TTATT utr-variant-3-prime
rs1063482 -- 75,530,216(-) ACTTG(A/C/G)AGATC stop-gained, reference, missense
rs1063483 -- 75,530,204(-) CTTAA(A/G)TATCC synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for COMMD6 Gene

Variant ID Type Subtype PubMed ID
nsv521444 CNV Gain 19592680
nsv900562 CNV Loss 21882294
dgv1692n71 CNV Loss 21882294
esv32759 CNV Loss 17666407
nsv1089 CNV Insertion 18451855
esv23690 CNV Gain 19812545
esv2596575 CNV Gain 19546169
nsv442676 CNV CNV 18776908
nsv514711 CNV Gain 21397061
esv2421984 CNV Duplication 20811451
nsv525594 CNV Gain 19592680
nsv818980 CNV Gain 17921354

Relevant External Links for COMMD6 Gene

HapMap Linkage Disequilibrium report
COMMD6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COMMD6 Gene

Disorders for COMMD6 Gene

No disorders were found for COMMD6 Gene.

No data available for UniProtKB/Swiss-Prot for COMMD6 Gene

Publications for COMMD6 Gene

  1. COMMD proteins, a novel family of structural and functional homologs of MURR1. (PMID: 15799966) Burstein E. … Duckett C.S. (J. Biol. Chem. 2005) 2 3 4
  2. Characterization of COMMD protein-protein interactions in NF-kappaB signalling. (PMID: 16573520) de Bie P. … Klomp L.W. (Biochem. J. 2006) 3 4
  3. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. CCDC22 deficiency in humans blunts activation of proinflammatory NF-I_B signaling. (PMID: 23563313) Starokadomskyy P. … Burstein E. (J. Clin. Invest. 2013) 3 4

Products for COMMD6 Gene

Sources for COMMD6 Gene

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