COMMD5 Gene
protein-coding GIFtS: 45
GCID: GC08M146067
|
|
COMM domain containing 5
| |
Aliases
for COMMD5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| COMM Domain Containing 51 2 | | FLJ130081 | | HCaRG1 3 | | HT0021 | | Hypertension-Related Calcium-Regulated Gene Protein2 3 | | COMM Domain-Containing Protein 52 | | HCARG2 5 | | |
Export aliases for COMMD5 gene to outside databasesPrevious GC identifers: GC08M146069 GC08M146035 GC08M146075 GC08M141191 |
Summaries
for COMMD5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: COMD5_HUMAN, Q9GZQ3Function: Down-regulates activation of NF-kappa-B
|
Genomic Views
for COMMD5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_037704.5
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the COMMD5 gene promoter:
AhR AML1a p300 AP-4
Other transcription factors
Search SABiosciences Chromatin IP Primers for COMMD5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COMMD5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q24.3 Ensembl cytogenetic band: 8q24.3 HGNC cytogenetic band: 8q24.3COMMD5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M146067: view genomic region
(about GC identifiers)
Start:
|
146,066,427 bp from pter |
End:
|
146,079,121 bp from pter |
Size:
|
12,695 bases |
Orientation:
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minus strand |
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Proteins
for COMMD5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: COMD5_HUMAN, Q9GZQ3 (See
protein sequence)Recommended Name: COMM domain-containing protein 5 Size: 224 amino acids; 24670 Da
Subunit: Interacts (via COMM domain) with COMMD1 (via COMM domain)
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=AAF14877.1; Type=Frameshift; Positions=66, 84, 112, 136;
Secondary accessions: D3DWN7 Q9NVN6 Q9UHX5Explore the universe of human proteins at neXtProt for COMMD5: NX_Q9GZQ3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9GZQ3
COMMD5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001074472.1 NP_001074473.1 NP_054785.2
ENSEMBL proteins: ENSP00000436382 ENSP00000385793 ENSP00000394331 ENSP00000304544 ENSP00000435552 ENSP00000433758
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
COMMD5 for ontologies About GeneDecksing
COMMD5 Antibody Products:
Assay Products for COMMD5: |
Protein
Domains /
Families
for COMMD5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
COMMD5 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9GZQ3ProtoNet protein and cluster: Q9GZQ3 1 Blocks protein family: IPB009886 HCaRG
UniProtKB/Swiss-Prot: COMD5_HUMAN, Q9GZQ3Similarity: Contains 1 COMM domain |
Function
for COMMD5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: COMD5_HUMAN, Q9GZQ3Function: Down-regulates activation of NF-kappa-B
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD5 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD5 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): COMMD5 (NM_001081004) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COMMD5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COMMD5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COMMD5 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
COMMD5 for ontologies About GeneDecksing
|
Pathways & Interactions
for COMMD5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for COMMD5
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5 Interacting proteins for COMMD5 (Q9GZQ33 ENSP000003045444) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007050 | cell cycle arrest |
-- | -- |
COMMD5 for ontologies About GeneDecksing
|
Drugs & Compounds
for COMMD5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for COMMD5
Search CenterWatch for drugs/clinical trials and news about COMMD5 / COMD5
|
Transcripts
for COMMD5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for COMMD5 gene (3 alternative transcripts): NM_001081003.1 NM_001081004.1 NM_014066.3 Unigene Cluster for COMMD5: COMM domain containing 5 Hs.631856 [show with all ESTs]Unigene Representative Sequence: AF1135406 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000530332(uc003zel.1) ENST00000402718(uc003zem.3) ENST00000450361(uc003zeo.4)
ENST00000305103(uc003zen.3) ENST00000529143 ENST00000533270
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD5 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD5 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): COMMD5 (NM_001081004) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COMMD5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COMMD5 |
Additional cDNA sequence: AF113540.1 AK001477.1 BC002672.2 BC003055.1 BC065729.1 11 DOTS entries: DT.95173493 DT.102842582 DT.97846081 DT.120630972 DT.97846079 DT.97846082 DT.100819077 DT.413712 DT.91871287 DT.100819074 DT.120630962 24/212 AceView cDNA sequences (see all 212): AI587223 AI240879 BQ013904 CA442509 CA450550 AI400947 CB529425 BC002672 AA298651 BU632763 BM694888 CD365143 AA780382 AI076231 NM_014066 CD671718 BU508224 BM762474 CA865895 AI027248 BI837049 AW005581 CA865627 AI424759
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for COMMD5 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d |
|---|
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| SP1: | | | | | | | - | | - | | - | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for COMMD5
|
Expression
for COMMD5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| COMMD5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See COMMD5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for COMMD5
SOURCE GeneReport for Unigene cluster: Hs.631856
UniProtKB/Swiss-Prot: COMD5_HUMAN, Q9GZQ3Tissue specificity: Highly expressed in heart, stomach, jejunum, kidney, liver, and adrenal gland. Expression wasgenerally higher in adult organs than in fetal tissues, particularly in heart, kidney, and liver
SABiosciences Custom PCR Arrays for COMMD5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COMMD5
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat COMMD5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COMMD5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COMMD5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COMMD5 |
Orthologs
for COMMD5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for COMMD5 gene from 5/16 species (see all 16) About this table
ENSEMBL Gene Tree for COMMD5 (if available)
TreeFam Gene Tree for COMMD5 (if available) |
Paralogs
for COMMD5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for COMMD5 gene
COMMD5 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for COMMD5
PGOHUM00000250767
|
Genomic Variants
for COMMD5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for COMMD5 (146066427 - 146079121 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for COMMD5: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COMMD5 |
|
Disorders
/ Diseases
for COMMD5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
COMMD5 for disorders About GeneDecksing
OMIM gene information: 608216
OMIM disorders: --
2  diseases for COMMD5: About MalaCardshypertension nephropathy
Human Genome Epidemiology (HuGE) Navigator: COMMD5 (1 document)
Export disorders for COMMD5 gene to outside databases
|
Publications
for COMMD5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for COMMD5 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with COMMD5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- HCaRG, a novel calcium-regulated gene coding for a nuclear protein, is potentially involved in the regulation of cell proliferation. (PubMed id 10918053)1, 2, 3, 9 Solban N.... Tremblay J. (2000)
- COMMD proteins, a novel family of structural and functional homologs of MURR1. (PubMed id 15799966)1, 2, 3 Burstein E....Duckett C.S. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
- Chromosomal mapping of HCaRG, a novel hypertension-related, calcium-regulated gene. (PubMed id 11871861)1, 9 Solban N....Tremblay J. (2002)
- Rosiglitazone suppresses gastric carcinogenesis by up-regulating HCaRG expression. (PubMed id 18949406)1, 9 Chen B.L....Leung W.K. (2008)
- HCaRG accelerates tubular repair after ischemic kidne y injury. (PubMed id 21921141)1 Matsuda H....Tremblay J. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Genome-wide linkage scans for type 2 diabetes mellitu s in four ethnically diverse populations-significant evidence for linkage on ch romosome 4q in African Americans: the Family Investigation of Nephropathy and D iabetes Research Group. (PubMed id 19795399)1 Malhotra A....Hanson R.L. (2009)
|
External Searches for COMMD5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing COMMD5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing COMMD5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing COMMD5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for COMMD5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for COMMD5 gene:
Search GeneIP for patents involving COMMD5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for COMMD5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for COMMD5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COMMD5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COMMD5 | | | OriGene Protein Over-expression Lysate for COMMD5 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for COMMD5 | | OriGene 3'-UTR Clone for COMMD5 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for COMMD5 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for COMMD5 | | OriGene Custom Protein Services for COMMD5 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat COMMD5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COMMD5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COMMD5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COMMD5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COMMD5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COMMD5 |
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| | | | Search Tocris compounds for COMMD5 |
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 | | | COMMD5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COMMD5 |
|  |  |  | | | | Search ThermoFisher Antibodies for COMMD5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COMMD5 |
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