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Aliases for COMMD5 Gene

Aliases for COMMD5 Gene

  • COMM Domain Containing 5 2 3 5
  • Hypertension-Related Calcium-Regulated Gene Protein 3 4
  • HCARG 3 4
  • HT002 3

External Ids for COMMD5 Gene

Previous GeneCards Identifiers for COMMD5 Gene

  • GC08M146069
  • GC08M146035
  • GC08M146075
  • GC08M141191
  • GC08M146067

Summaries for COMMD5 Gene

GeneCards Summary for COMMD5 Gene

COMMD5 (COMM Domain Containing 5) is a Protein Coding gene.

UniProtKB/Swiss-Prot for COMMD5 Gene

  • May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis (By similarity). Down-regulates activation of NF-kappa-B (PubMed:15799966).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COMMD5 Gene

Genomics for COMMD5 Gene

Regulatory Elements for COMMD5 Gene

Enhancers for COMMD5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around COMMD5 on UCSC Golden Path with GeneCards custom track

Promoters for COMMD5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around COMMD5 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the COMMD5 gene promoter:

Genomic Location for COMMD5 Gene

Chromosome:
8
Start:
144,837,978 bp from pter
End:
144,853,736 bp from pter
Size:
15,759 bases
Orientation:
Minus strand

Genomic View for COMMD5 Gene

Genes around COMMD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COMMD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COMMD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COMMD5 Gene

Proteins for COMMD5 Gene

  • Protein details for COMMD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZQ3-COMD5_HUMAN
    Recommended name:
    COMM domain-containing protein 5
    Protein Accession:
    Q9GZQ3
    Secondary Accessions:
    • D3DWN7
    • Q9NVN6
    • Q9UHX5

    Protein attributes for COMMD5 Gene

    Size:
    224 amino acids
    Molecular mass:
    24670 Da
    Quaternary structure:
    • Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with RELA, RELB, NFKB1/p105. Interacts with CCDC22, CCDC93, SCNN1B, CUL2, CUL3, CUL4A, CUL4B, CUL7.
    SequenceCaution:
    • Sequence=AAF14877.1; Type=Frameshift; Positions=66, 84, 112, 136; Evidence={ECO:0000305};

neXtProt entry for COMMD5 Gene

Proteomics data for COMMD5 Gene at MOPED

Post-translational modifications for COMMD5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for COMMD5 Gene

Domains & Families for COMMD5 Gene

Gene Families for COMMD5 Gene

Protein Domains for COMMD5 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for COMMD5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9GZQ3

UniProtKB/Swiss-Prot:

COMD5_HUMAN :
  • Contains 1 COMM domain.
Domain:
  • Contains 1 COMM domain.
genes like me logo Genes that share domains with COMMD5: view

Function for COMMD5 Gene

Molecular function for COMMD5 Gene

UniProtKB/Swiss-Prot Function:
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis (By similarity). Down-regulates activation of NF-kappa-B (PubMed:15799966).

Phenotypes for COMMD5 Gene

GenomeRNAi human phenotypes for COMMD5:
genes like me logo Genes that share phenotypes with COMMD5: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COMMD5 Gene

Localization for COMMD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COMMD5 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COMMD5 Gene COMPARTMENTS Subcellular localization image for COMMD5 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for COMMD5 Gene

Pathways & Interactions for COMMD5 Gene

SuperPathways for COMMD5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for COMMD5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for COMMD5 Gene

Drugs & Compounds for COMMD5 Gene

No Compound Related Data Available

Transcripts for COMMD5 Gene

Unigene Clusters for COMMD5 Gene

COMM domain containing 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COMMD5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d
SP1: - - -
SP2: - -
SP3: -
SP4:

Relevant External Links for COMMD5 Gene

GeneLoc Exon Structure for
COMMD5
ECgene alternative splicing isoforms for
COMMD5

Expression for COMMD5 Gene

mRNA expression in normal human tissues for COMMD5 Gene

Protein differential expression in normal tissues from HIPED for COMMD5 Gene

This gene is overexpressed in Monocytes (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for COMMD5 Gene



SOURCE GeneReport for Unigene cluster for COMMD5 Gene Hs.631856

mRNA Expression by UniProt/SwissProt for COMMD5 Gene

Q9GZQ3-COMD5_HUMAN
Tissue specificity: Highly expressed in heart, stomach, jejunum, kidney, liver, and adrenal gland. Expression was generally higher in adult organs than in fetal tissues, particularly in heart, kidney, and liver.
genes like me logo Genes that share expression patterns with COMMD5: view

Protein tissue co-expression partners for COMMD5 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for COMMD5 Gene

Orthologs for COMMD5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for COMMD5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia COMMD5 35
  • 85.57 (n)
  • 87.5 (a)
COMMD5 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COMMD5 35
  • 83.33 (n)
  • 84.82 (a)
COMMD5 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Commd5 35
  • 79.46 (n)
  • 79.46 (a)
Commd5 16
Commd5 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia COMMD5 35
  • 98.66 (n)
  • 98.66 (a)
COMMD5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Commd5 35
  • 79.76 (n)
  • 80.36 (a)
chicken
(Gallus gallus)
Aves COMMD5 35
  • 59.76 (n)
  • 54.5 (a)
COMMD5 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia commd5 35
  • 57.55 (n)
  • 52.47 (a)
Str.138 35
zebrafish
(Danio rerio)
Actinopterygii commd5 35
  • 54.08 (n)
  • 47.06 (a)
commd5 36
  • 45 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.624 35
Species with no ortholog for COMMD5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COMMD5 Gene

ENSEMBL:
Gene Tree for COMMD5 (if available)
TreeFam:
Gene Tree for COMMD5 (if available)

Paralogs for COMMD5 Gene

Pseudogenes.org Pseudogenes for COMMD5 Gene

genes like me logo Genes that share paralogs with COMMD5: view

No data available for Paralogs for COMMD5 Gene

Variants for COMMD5 Gene

Sequence variations from dbSNP and Humsavar for COMMD5 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1209879 - 144,851,323(-) TGGGG(A/G)CTGCA nc-transcript-variant, reference, missense
rs421427 - 144,851,132(-) GTGCA(C/G)CGTCT nc-transcript-variant, reference, missense
rs2722478 -- 144,854,301(-) TATGT(C/T)GCCCA upstream-variant-2KB
rs2722480 -- 144,849,260(-) TCCCC(A/G)AAGGC intron-variant
rs2727227 -- 144,852,887(-) GTGTT(C/G)GGAGA intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for COMMD5 Gene

Variant ID Type Subtype PubMed ID
nsv469809 CNV Loss 16826518
nsv6450 CNV Insertion 18451855

Variation tolerance for COMMD5 Gene

Residual Variation Intolerance Score: 73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.15; 75.71% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for COMMD5 Gene

Disorders for COMMD5 Gene

Relevant External Links for COMMD5

Genetic Association Database (GAD)
COMMD5
Human Genome Epidemiology (HuGE) Navigator
COMMD5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COMMD5

No disorders were found for COMMD5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COMMD5 Gene

Publications for COMMD5 Gene

  1. HCaRG, a novel calcium-regulated gene coding for a nuclear protein, is potentially involved in the regulation of cell proliferation. (PMID: 10918053) Solban N. … Tremblay J. (J. Biol. Chem. 2000) 2 3 4 23 67
  2. Rosiglitazone suppresses gastric carcinogenesis by up-regulating HCaRG expression. (PMID: 18949406) Chen B.L. … Leung W.K. (Oncol. Rep. 2008) 3 23
  3. COMMD proteins, a novel family of structural and functional homologs of MURR1. (PMID: 15799966) Burstein E. … Duckett C.S. (J. Biol. Chem. 2005) 2 3
  4. Chromosomal mapping of HCaRG, a novel hypertension-related, calcium-regulated gene. (PMID: 11871861) Solban N. … Tremblay J. (Folia Biol. (Praha) 2002) 3 23
  5. COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A. (PMID: 25355947) Phillips-Krawczak C.A. … Burstein E. (Mol. Biol. Cell 2015) 3

Products for COMMD5 Gene

Sources for COMMD5 Gene

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