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Aliases for COMMD5 Gene

Aliases for COMMD5 Gene

  • COMM Domain Containing 5 2 3
  • HCARG 3 4 6
  • Hypertension-Related Calcium-Regulated Gene Protein 3 4
  • COMM Domain-Containing Protein 5 3
  • HT002 3

External Ids for COMMD5 Gene

Previous GeneCards Identifiers for COMMD5 Gene

  • GC08M146069
  • GC08M146035
  • GC08M146075
  • GC08M141191
  • GC08M146067

Summaries for COMMD5 Gene

GeneCards Summary for COMMD5 Gene

COMMD5 (COMM Domain Containing 5) is a Protein Coding gene.

UniProtKB/Swiss-Prot for COMMD5 Gene

  • May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis (By similarity). Down-regulates activation of NF-kappa-B (PubMed:15799966).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COMMD5 Gene

Genomics for COMMD5 Gene

Regulatory Elements for COMMD5 Gene

Transcription factor binding sites by QIAGEN in the COMMD5 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for COMMD5 Gene

Start:
144,837,974 bp from pter
End:
144,853,736 bp from pter
Size:
15,763 bases
Orientation:
Minus strand

Genomic View for COMMD5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COMMD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COMMD5 Gene

Proteins for COMMD5 Gene

  • Protein details for COMMD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZQ3-COMD5_HUMAN
    Recommended name:
    COMM domain-containing protein 5
    Protein Accession:
    Q9GZQ3
    Secondary Accessions:
    • D3DWN7
    • Q9NVN6
    • Q9UHX5

    Protein attributes for COMMD5 Gene

    Size:
    224 amino acids
    Molecular mass:
    24670 Da
    Quaternary structure:
    • Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with RELA, RELB, NFKB1/p105. Interacts with CCDC22, CCDC93, SCNN1B, CUL2, CUL3, CUL4A, CUL4B, CUL7.
    SequenceCaution:
    • Sequence=AAF14877.1; Type=Frameshift; Positions=66, 84, 112, 136; Evidence={ECO:0000305};

neXtProt entry for COMMD5 Gene

Proteomics data for COMMD5 Gene at MOPED

Post-translational modifications for COMMD5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for COMMD5 Gene

Domains for COMMD5 Gene

Protein Domains for COMMD5 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for COMMD5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9GZQ3

UniProtKB/Swiss-Prot:

COMD5_HUMAN :
  • Q9GZQ3
Domain:
  • Contains 1 COMM domain.
genes like me logo Genes that share domains with COMMD5: view

No data available for Gene Families for COMMD5 Gene

Function for COMMD5 Gene

Molecular function for COMMD5 Gene

UniProtKB/Swiss-Prot Function:
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis (By similarity). Down-regulates activation of NF-kappa-B (PubMed:15799966).

Gene Ontology (GO) - Molecular Function for COMMD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15799966
genes like me logo Genes that share ontologies with COMMD5: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COMMD5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for COMMD5 Gene

Localization for COMMD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COMMD5 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COMMD5 Gene COMPARTMENTS Subcellular localization image for COMMD5 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for COMMD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with COMMD5: view

Pathways for COMMD5 Gene

SuperPathways for COMMD5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for COMMD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with COMMD5: view

No data available for Pathways by source for COMMD5 Gene

Transcripts for COMMD5 Gene

Unigene Clusters for COMMD5 Gene

COMM domain containing 5:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COMMD5

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COMMD5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d
SP1: - - -
SP2: - -
SP3: -
SP4:

Relevant External Links for COMMD5 Gene

GeneLoc Exon Structure for
COMMD5
ECgene alternative splicing isoforms for
COMMD5

Expression for COMMD5 Gene

mRNA expression in normal human tissues for COMMD5 Gene

Protein differential expression in normal tissues for COMMD5 Gene

This gene is overexpressed in Monocytes (9.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COMMD5 Gene

SOURCE GeneReport for Unigene cluster for COMMD5 Gene Hs.631856

mRNA Expression by UniProt/SwissProt for COMMD5 Gene

Q9GZQ3-COMD5_HUMAN
Tissue specificity: Highly expressed in heart, stomach, jejunum, kidney, liver, and adrenal gland. Expression was generally higher in adult organs than in fetal tissues, particularly in heart, kidney, and liver.
genes like me logo Genes that share expressions with COMMD5: view

Expression partners for COMMD5 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for COMMD5 Gene

Orthologs for COMMD5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for COMMD5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia COMMD5 35
  • 85.57 (n)
  • 87.5 (a)
COMMD5 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COMMD5 35
  • 83.33 (n)
  • 84.82 (a)
COMMD5 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Commd5 35
  • 79.46 (n)
  • 79.46 (a)
Commd5 16
Commd5 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia COMMD5 35
  • 98.66 (n)
  • 98.66 (a)
COMMD5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Commd5 35
  • 79.76 (n)
  • 80.36 (a)
chicken
(Gallus gallus)
Aves COMMD5 35
  • 59.76 (n)
  • 54.5 (a)
COMMD5 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia commd5 35
  • 57.55 (n)
  • 52.47 (a)
Str.138 35
zebrafish
(Danio rerio)
Actinopterygii commd5 35
  • 54.08 (n)
  • 47.06 (a)
commd5 36
  • 45 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.624 35
Species with no ortholog for COMMD5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COMMD5 Gene

ENSEMBL:
Gene Tree for COMMD5 (if available)
TreeFam:
Gene Tree for COMMD5 (if available)

Paralogs for COMMD5 Gene

Pseudogenes.org Pseudogenes for COMMD5 Gene

genes like me logo Genes that share paralogs with COMMD5: view

No data available for Paralogs for COMMD5 Gene

Variants for COMMD5 Gene

Sequence variations from dbSNP and Humsavar for COMMD5 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs410352 -- 144,851,245(-) CTCCA(A/G)AGGTG missense, reference, nc-transcript-variant
rs416507 -- 144,851,143(-) GCCGA(A/G)AGGCT missense, reference, nc-transcript-variant
rs421427 - 144,851,132(-) GTGCA(C/G)CGTCT missense, reference, nc-transcript-variant
rs909246 -- 144,848,063(+) TTTCA(C/T)GGCTG intron-variant
rs909276 -- 144,850,400(-) TTTGT(C/T)TTTGG utr-variant-3-prime, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COMMD5 Gene

Variant ID Type Subtype PubMed ID
nsv469809 CNV Loss 16826518
nsv6450 CNV Insertion 18451855

Relevant External Links for COMMD5 Gene

HapMap Linkage Disequilibrium report
COMMD5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COMMD5 Gene

Disorders for COMMD5 Gene

Relevant External Links for COMMD5

Genetic Association Database (GAD)
COMMD5
Human Genome Epidemiology (HuGE) Navigator
COMMD5

No disorders were found for COMMD5 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for COMMD5 Gene

Publications for COMMD5 Gene

  1. HCaRG, a novel calcium-regulated gene coding for a nuclear protein, is potentially involved in the regulation of cell proliferation. (PMID: 10918053) Solban N. … Tremblay J. (J. Biol. Chem. 2000) 2 3 4 23
  2. COMMD proteins, a novel family of structural and functional homologs of MURR1. (PMID: 15799966) Burstein E. … Duckett C.S. (J. Biol. Chem. 2005) 2 3 4
  3. Genome-wide linkage scans for type 2 diabetes mellitus in four ethnically diverse populations-significant evidence for linkage on chromosome 4q in African Americans: the Family Investigation of Nephropathy and Diabetes Research Group. (PMID: 19795399) Malhotra A. … Hanson R.L. (Diabetes Metab. Res. Rev. 2009) 3 48
  4. Chromosomal mapping of HCaRG, a novel hypertension-related, calcium-regulated gene. (PMID: 11871861) Solban N. … Tremblay J. (Folia Biol. (Praha) 2002) 3 23
  5. Rosiglitazone suppresses gastric carcinogenesis by up-regulating HCaRG expression. (PMID: 18949406) Chen B.L. … Leung W.K. (Oncol. Rep. 2008) 3 23

Products for COMMD5 Gene

Sources for COMMD5 Gene

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