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Aliases for COMMD5 Gene

Aliases for COMMD5 Gene

  • COMM Domain Containing 5 2 3 5
  • Hypertension-Related Calcium-Regulated Gene Protein 3 4
  • HCARG 3 4
  • COMM Domain-Containing Protein 5 3
  • HT002 3

External Ids for COMMD5 Gene

Previous GeneCards Identifiers for COMMD5 Gene

  • GC08M146069
  • GC08M146035
  • GC08M146075
  • GC08M141191
  • GC08M146067

Summaries for COMMD5 Gene

GeneCards Summary for COMMD5 Gene

COMMD5 (COMM Domain Containing 5) is a Protein Coding gene.

UniProtKB/Swiss-Prot for COMMD5 Gene

  • May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis (By similarity). Down-regulates activation of NF-kappa-B (PubMed:15799966).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COMMD5 Gene

Genomics for COMMD5 Gene

Regulatory Elements for COMMD5 Gene

Enhancers for COMMD5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F143914 1.9 FANTOM5 Ensembl ENCODE 22.4 +916.6 916606 45.2 MLX CREB3L1 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 ZNF251 ZNF250 ZNF517 LRRC14 PLEC LOC105375803 ZNF696 ZNF623 VPS28 COMMD5
GH08F144455 1.4 Ensembl ENCODE 24.6 +397.3 397290 1.6 PKNOX1 ARNT CREB3L1 ZFP64 SIN3A ZNF2 ZNF416 ZNF207 ZNF548 FOS ZNF623 ZNF251 ZNF250 VPS28 GPAA1 LRRC14 LOC105375803 ZNF517 ZNF34 PPP1R16A
GH08F144770 1.3 FANTOM5 Ensembl ENCODE 15.7 +83.1 83136 1.2 KLF1 LEF1 ESRRA HINFP ZNF175 PTRF PYGO2 ZNF644 NCOR1 NR2F6 RPL8 LRRC14 COMMD5 ZNF517 ZNF250 ADCK5 VPS28 LOC105375803 ZNF251 ZNF34
GH08F144011 1.6 FANTOM5 Ensembl ENCODE 12 +840.4 840365 3.9 HDGF TBL1XR1 INSM2 KLF17 SIN3A ZEB1 ZNF155 GLIS2 ZNF366 SCRT2 PLEC SPATC1 ZNF250 ZNF623 VPS28 GPAA1 COMMD5 SLC52A2 ZNF251 ADCK5
GH08F144101 1.2 ENCODE 14.4 +749.8 749825 4.0 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF416 ZNF623 ZNF250 ZNF251 ZNF517 LRRC14 TMED10P1 ENSG00000255164 WDR97 ZNF696 VPS28
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around COMMD5 on UCSC Golden Path with GeneCards custom track

Promoters for COMMD5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001404537 836 2201 CREB3L1 ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF143 ZNF263 SP3 SP5

Genomic Location for COMMD5 Gene

Chromosome:
8
Start:
144,837,978 bp from pter
End:
144,853,736 bp from pter
Size:
15,759 bases
Orientation:
Minus strand

Genomic View for COMMD5 Gene

Genes around COMMD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COMMD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COMMD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COMMD5 Gene

Proteins for COMMD5 Gene

  • Protein details for COMMD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZQ3-COMD5_HUMAN
    Recommended name:
    COMM domain-containing protein 5
    Protein Accession:
    Q9GZQ3
    Secondary Accessions:
    • D3DWN7
    • Q9NVN6
    • Q9UHX5

    Protein attributes for COMMD5 Gene

    Size:
    224 amino acids
    Molecular mass:
    24670 Da
    Quaternary structure:
    • Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with RELA, RELB, NFKB1/p105. Interacts with CCDC22, CCDC93, SCNN1B, CUL2, CUL3, CUL4A, CUL4B, CUL7.
    SequenceCaution:
    • Sequence=AAF14877.1; Type=Frameshift; Positions=66, 84, 112, 136; Evidence={ECO:0000305};

neXtProt entry for COMMD5 Gene

Post-translational modifications for COMMD5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for COMMD5 Gene

Domains & Families for COMMD5 Gene

Gene Families for COMMD5 Gene

Protein Domains for COMMD5 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for COMMD5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9GZQ3

UniProtKB/Swiss-Prot:

COMD5_HUMAN :
  • Contains 1 COMM domain.
Domain:
  • Contains 1 COMM domain.
genes like me logo Genes that share domains with COMMD5: view

Function for COMMD5 Gene

Molecular function for COMMD5 Gene

UniProtKB/Swiss-Prot Function:
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis (By similarity). Down-regulates activation of NF-kappa-B (PubMed:15799966).

Gene Ontology (GO) - Molecular Function for COMMD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15799966
genes like me logo Genes that share ontologies with COMMD5: view

Phenotypes for COMMD5 Gene

GenomeRNAi human phenotypes for COMMD5:
genes like me logo Genes that share phenotypes with COMMD5: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COMMD5 Gene

Localization for COMMD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COMMD5 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for COMMD5 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1
mitochondrion 1
lysosome 1
endosome 1

Gene Ontology (GO) - Cellular Components for COMMD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with COMMD5: view

Pathways & Interactions for COMMD5 Gene

SuperPathways for COMMD5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for COMMD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with COMMD5: view

No data available for Pathways by source and SIGNOR curated interactions for COMMD5 Gene

Transcripts for COMMD5 Gene

Unigene Clusters for COMMD5 Gene

COMM domain containing 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COMMD5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d
SP1: - - -
SP2: - -
SP3: -
SP4:

Relevant External Links for COMMD5 Gene

GeneLoc Exon Structure for
COMMD5
ECgene alternative splicing isoforms for
COMMD5

Expression for COMMD5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for COMMD5 Gene

Protein differential expression in normal tissues from HIPED for COMMD5 Gene

This gene is overexpressed in Monocytes (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for COMMD5 Gene



Protein tissue co-expression partners for COMMD5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of COMMD5 Gene:

COMMD5

SOURCE GeneReport for Unigene cluster for COMMD5 Gene:

Hs.631856

mRNA Expression by UniProt/SwissProt for COMMD5 Gene:

Q9GZQ3-COMD5_HUMAN
Tissue specificity: Highly expressed in heart, stomach, jejunum, kidney, liver, and adrenal gland. Expression was generally higher in adult organs than in fetal tissues, particularly in heart, kidney, and liver.
genes like me logo Genes that share expression patterns with COMMD5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for COMMD5 Gene

Orthologs for COMMD5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for COMMD5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COMMD5 34 35
  • 98.66 (n)
cow
(Bos Taurus)
Mammalia COMMD5 34 35
  • 85.57 (n)
dog
(Canis familiaris)
Mammalia COMMD5 34 35
  • 83.33 (n)
rat
(Rattus norvegicus)
Mammalia Commd5 34
  • 79.76 (n)
mouse
(Mus musculus)
Mammalia Commd5 34 16 35
  • 79.46 (n)
chicken
(Gallus gallus)
Aves COMMD5 34 35
  • 59.76 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia commd5 34
  • 57.55 (n)
Str.138 34
zebrafish
(Danio rerio)
Actinopterygii commd5 34 35
  • 54.08 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.624 34
Species where no ortholog for COMMD5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COMMD5 Gene

ENSEMBL:
Gene Tree for COMMD5 (if available)
TreeFam:
Gene Tree for COMMD5 (if available)

Paralogs for COMMD5 Gene

Pseudogenes.org Pseudogenes for COMMD5 Gene

genes like me logo Genes that share paralogs with COMMD5: view

No data available for Paralogs for COMMD5 Gene

Variants for COMMD5 Gene

Sequence variations from dbSNP and Humsavar for COMMD5 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10081481 -- 144,846,931(+) ctgac(A/C)tcgtg intron-variant, utr-variant-3-prime
rs10544649 -- 144,843,610(+) AAAAA(-/A)TCCAA intron-variant, downstream-variant-500B
rs111392496 -- 144,853,212(+) GACAG(-/T)TTTTT intron-variant, upstream-variant-2KB
rs111427996 -- 144,854,145(+) GGGGA(C/T)ACAGA upstream-variant-2KB
rs111562571 -- 144,843,311(+) CAGGC(C/T)GAGTG intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for COMMD5 Gene

Variant ID Type Subtype PubMed ID
nsv6450 CNV insertion 18451855
nsv612969 CNV loss 21841781
nsv469809 CNV loss 16826518
nsv1031737 CNV gain 25217958
nsv1023752 CNV gain 25217958

Variation tolerance for COMMD5 Gene

Residual Variation Intolerance Score: 73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.15; 75.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COMMD5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
COMMD5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COMMD5 Gene

Disorders for COMMD5 Gene

Relevant External Links for COMMD5

Genetic Association Database (GAD)
COMMD5
Human Genome Epidemiology (HuGE) Navigator
COMMD5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COMMD5

No disorders were found for COMMD5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COMMD5 Gene

Publications for COMMD5 Gene

  1. HCaRG, a novel calcium-regulated gene coding for a nuclear protein, is potentially involved in the regulation of cell proliferation. (PMID: 10918053) Solban N. … Tremblay J. (J. Biol. Chem. 2000) 2 3 4 22 64
  2. COMMD proteins, a novel family of structural and functional homologs of MURR1. (PMID: 15799966) Burstein E. … Duckett C.S. (J. Biol. Chem. 2005) 2 3 4 64
  3. COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A. (PMID: 25355947) Phillips-Krawczak C.A. … Burstein E. (Mol. Biol. Cell 2015) 3 4 64
  4. CCDC22 deficiency in humans blunts activation of proinflammatory NF-I_B signaling. (PMID: 23563313) Starokadomskyy P. … Burstein E. (J. Clin. Invest. 2013) 3 4 64
  5. COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding. (PMID: 21778237) Mao X. … Burstein E. (J. Biol. Chem. 2011) 3 4 64

Products for COMMD5 Gene

Sources for COMMD5 Gene

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