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COMMD4 Gene

protein-coding   GIFtS: 49
GCID: GC15P075628

COMM Domain Containing 4

  Search for COMMD4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
COMM Domain Containing 41 2
COMM Domain-Containing Protein 42

External Ids:    HGNC: 260271   Entrez Gene: 549392   Ensembl: ENSG000001403657   UniProtKB: Q9H0A83   

Export aliases for COMMD4 gene to outside databases

Previous GC identifers: GC15P073345 GC15P073415 GC15P052386


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for COMMD4 Gene:
COMMD4 (COMM domain containing 4) is a protein-coding gene.

UniProtKB/Swiss-Prot: COMD4_HUMAN, Q9H0A8
Function: Down-regulates activation of NF-kappa-B

Gene Wiki entry for COMMD4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the COMMD4 gene promoter:
         AhR   GATA-3   RelA   NF-kappaB   Arnt   CREB   FOXO4   deltaCREB   Zic3   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOMMD4 promoter sequence
   Search Chromatin IP Primers for COMMD4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COMMD4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24.2   Ensembl cytogenetic band:  15q24.2   HGNC cytogenetic band: 15q24.2

COMMD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COMMD4 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P075628:  view genomic region     (about GC identifiers)

Start:
75,628,232 bp from pter      End:
75,634,268 bp from pter
Size:
6,037 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: COMD4_HUMAN, Q9H0A8 (See protein sequence)
Recommended Name: COMM domain-containing protein 4  
Size: 199 amino acids; 21764 Da
Subunit: Interacts (via COMM domain) with COMMD1 (via COMM domain)
Secondary accessions: B2RBN4 Q7L637 Q9NX43
Alternative splicing: 2 isoforms:  Q9H0A8-1   Q9H0A8-2   

Explore the universe of human proteins at neXtProt for COMMD4: NX_Q9H0A8

Explore proteomics data for COMMD4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys50, Lys113, Lys180
  • Modification sites at PhosphoSitePlus

  • See COMMD4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001271306.1  NP_001271307.1  NP_001271308.1  NP_060298.2  

    ENSEMBL proteins: 
     ENSP00000267935   ENSP00000457693   ENSP00000455249   ENSP00000456440   ENSP00000340867  
     ENSP00000457348   ENSP00000433662   ENSP00000455303   ENSP00000455750   ENSP00000454283  

    COMMD4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals COMMD4 Protein
    Novus Biologicals COMMD4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for COMMD4

     
    Search eBioscience for Proteins for COMMD4 

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    LSBio Antibodies in human, mouse, rat for COMMD4

    COMMD4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for COMMD4
    Cloud-Clone Corp. CLIAs for COMMD4
    Search eBioscience for ELISAs for COMMD4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR017920 COMM
     IPR009886 HCaRG

    Graphical View of Domain Structure for InterPro Entry Q9H0A8

    ProtoNet protein and cluster: Q9H0A8

    1 Blocks protein domain: IPB009886 HCaRG

    UniProtKB/Swiss-Prot: COMD4_HUMAN, Q9H0A8
    Similarity: Contains 1 COMM domain


    Find genes that share domains with COMMD4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COMD4_HUMAN, Q9H0A8
    Function: Down-regulates activation of NF-kappa-B

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15799966
         
    Find genes that share ontologies with COMMD4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for COMMD4:
     Upregulation of NF-kappaB path 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for COMMD4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for COMMD4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for COMMD4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for COMMD4

    miRNA
    Products:
        
    miRTarBase miRNAs that target COMMD4:
    hsa-mir-502-3p (MIRT037986), hsa-mir-500a-3p (MIRT041159), hsa-mir-320a (MIRT044655)

    Block miRNA regulation of human, mouse, rat COMMD4 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate COMMD4
    SwitchGear 3'UTR luciferase reporter plasmidCOMMD4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for COMMD4
    Predesigned siRNA for gene silencing in human, mouse, rat COMMD4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for COMMD4

    Clone
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    OriGene clones in human, mouse for COMMD4 (see all 7)
    OriGene ORF clones in mouse, rat for COMMD4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: COMMD4 (NM_017828)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COMMD4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COMMD4

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COMMD4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular2
    cytosol1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with COMMD4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including COMMD4: 
              Necrosis in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Cell Death PathwayFinder in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for COMMD4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for COMMD4 (Q9H0A81, 3 ENSP000002679354) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COMMD1Q8N6681, 3, ENSP000003082364EBI-1550064,EBI-1550112 I2D: score=2 STRING: ENSP00000308236
    NFKB1P198383, ENSP000002265744I2D: score=1 STRING: ENSP00000226574
    RELBQ012013, ENSP000002214524I2D: score=1 STRING: ENSP00000221452
    RELAQ042063, ENSP000003842734I2D: score=1 STRING: ENSP00000384273
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for COMMD4 (COMD4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for COMMD4 gene (4 alternative transcripts): 
    NM_001284377.1  NM_001284378.1  NM_001284379.1  NM_017828.4  

    Unigene Cluster for COMMD4:

    COMM domain containing 4
    Hs.351327  [show with all ESTs]
    Unigene Representative Sequence: AK124968
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000267935(uc002azy.3 uc002azz.3 uc002baa.3) ENST00000567195
    ENST00000566843(uc010umf.1 uc010umg.2) ENST00000564815 ENST00000562610
    ENST00000338995 ENST00000567023 ENST00000567720 ENST00000566230 ENST00000564587
    ENST00000565517 ENST00000564068 ENST00000480484 ENST00000567399 ENST00000561662
    ENST00000568034 ENST00000567377 ENST00000562789
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat COMMD4 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate COMMD4
    SwitchGear 3'UTR luciferase reporter plasmidCOMMD4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for COMMD4
    Predesigned siRNA for gene silencing in human, mouse, rat COMMD4
    Clone
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    OriGene clones in human, mouse for COMMD4 (see all 7)
    OriGene ORF clones in mouse, rat for COMMD4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: COMMD4 (NM_017828)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COMMD4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COMMD4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for COMMD4
    OriGene qSTAR qPCR primer pairs in human, mouse for COMMD4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat COMMD4
      QuantiTect SYBR Green Assays in human, mouse, rat COMMD4
      QuantiFast Probe-based Assays in human, mouse, rat COMMD4

    Additional mRNA sequence: 

    AK000459.1 AK057145.1 AK124968.1 AK225716.1 AK293708.1 AK314740.1 AY542160.1 BC000837.2 
    BC033744.1 BC040944.2 BC068998.1 BC069195.1 CR533452.1 

    Selected DOTS entries (see all 25):

    DT.91922733  DT.91754427  DT.97864304  DT.100797207  DT.91754414  DT.91754426  DT.121052633  DT.121052934 
    DT.121052643  DT.121052632  DT.455253  DT.101984562  DT.100797208  DT.91916484  DT.121052920  DT.102839746 
    DT.91754435  DT.100797202  DT.100833559  DT.121052978  DT.91754422  DT.95256477  DT.97864303  DT.100763886 

    Selected AceView cDNA sequences (see all 324):

    AI148280 AA770343 AI806309 CA309263 AA429906 AW027633 AI559350 AA609100 
    AW069258 BM782873 BE858465 BM708705 BQ009620 BM972849 AI083877 AI096853 
    BM708710 BQ638981 BC033744 BU731903 BC000837 BC040944 BM913977 BF436043 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for COMMD4    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
    SP1:                                      -                           
    SP2:                                      -     -                     
    SP3:                                                                  


    ECgene alternative splicing isoforms for COMMD4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    COMMD4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCCTCTCAG
    COMMD4 Expression
    About this image

    COMMD4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    COMMD4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.351327

    UniProtKB/Swiss-Prot: COMD4_HUMAN, Q9H0A8
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Arrays including COMMD4: 
              Necrosis in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Cell Death PathwayFinder in human mouse rat

    Primer
    Products:
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    QuantiFast Probe-based Assays in human, mouse, rat COMMD4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COMMD4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for COMMD4 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Commd41 , 5 COMM domain containing 41, 5 86.93(n)1
    90.95(a)1
      9 (30.89 cM)5
    661991  NM_025417.21  NP_079693.11 
     571550415 
    chicken
    (Gallus gallus)
    Aves COMMD41 COMM domain containing 4 73.23(n)
    73.23(a)
      770048  NM_001277632.1  NP_001264561.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.151292 Xenopus laevis transcribed sequence with moderate similarity more 72.02(n)    BU905041.1 
    zebrafish
    (Danio rerio)
    Actinopterygii commd41 COMM domain containing 4 69.03(n)
    74.8(a)
      767771  NM_001076738.1  NP_001070206.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG340391 CG34039 45.45(n)
    36.9(a)
      3885643  NM_001038923.3  NP_001034012.2 


    ENSEMBL Gene Tree for COMMD4 (if available)
    TreeFam Gene Tree for COMMD4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for COMMD4 gene

    Find genes that share paralogs with COMMD4           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for COMMD4
    PGOHUM00000262228 PGOHUM00000262229 PGOHUM00000262256


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for COMMD4 (see all 184)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105271611,2
    C--75626542(+) CAGCC-/TTT   
       ATTTA
    TTTAT
    1 -- us2k1 tfbs30--------
    rs1137731311,2
    C--75626542(+) CAGCCTTTA/-  
            
    TTTAT
    1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs2000608721,2
    --75626579(+) TTTTT-/ATTTTA 1 -- us2k10--------
    rs1840766231,2
    --75626677(+) CCAGGA/CTCAAG 1 -- us2k10--------
    rs1888569091,2
    --75626855(+) AGGTCC/TTAACA 1 -- us2k10--------
    rs1808438661,2
    --75626872(+) AAAAAA/TTTTTT 1 -- us2k10--------
    rs1838288531,2
    --75627017(+) TATAGC/TGCAGT 1 -- us2k10--------
    rs589792211,2
    C--75627278(+) TGAGGC/TAGGAG 1 -- us2k10--------
    rs800980071,2
    F--75627396(+) ACTTTA/GTAACA 1 -- us2k11Minor allele frequency- G:0.07WA 118
    rs781041811,2
    C,F--75627432(+) ATTAGG/TTATTA 1 -- us2k12Minor allele frequency- T:0.05WA 120

    HapMap Linkage Disequilibrium report for COMMD4 (75628232 - 75634268 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for COMMD4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749894CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing COMMD4
    DNA2.0 Custom Variant and Variant Library Synthesis for COMMD4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for COMMD4 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with COMMD4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. COMMD proteins, a novel family of structural and functional homologs of MURR1. (PubMed id 15799966)1, 2, 3 Burstein E.... Duckett C.S. (J. Biol. Chem. 2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    5. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54939 HGNC: 26027 AceView: COMMD4 Ensembl:ENSG00000140365 euGenes: HUgn54939
    ECgene: COMMD4 H-InvDB: COMMD4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for COMMD4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for COMMD4 gene:
    Search GeneIP for patents involving COMMD4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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