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Aliases for COMMD4 Gene

Aliases for COMMD4 Gene

  • COMM Domain Containing 4 2 3

External Ids for COMMD4 Gene

Previous GeneCards Identifiers for COMMD4 Gene

  • GC15P073345
  • GC15P073415
  • GC15P075628
  • GC15P052386

Summaries for COMMD4 Gene

GeneCards Summary for COMMD4 Gene

COMMD4 (COMM Domain Containing 4) is a Protein Coding gene.

UniProtKB/Swiss-Prot for COMMD4 Gene

  • May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Down-regulates activation of NF-kappa-B.

Gene Wiki entry for COMMD4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COMMD4 Gene

Genomics for COMMD4 Gene

Regulatory Elements for COMMD4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for COMMD4 Gene

75,335,891 bp from pter
75,343,224 bp from pter
7,334 bases
Plus strand

Genomic View for COMMD4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COMMD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COMMD4 Gene

Proteins for COMMD4 Gene

  • Protein details for COMMD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    COMM domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • B2RBN4
    • H3BUL2
    • Q7L637
    • Q9NX43

    Protein attributes for COMMD4 Gene

    199 amino acids
    Molecular mass:
    21764 Da
    Quaternary structure:
    • Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with RELA, RELB, NFKB1/p105. Interacts with CCDC22, CCDC93, SCNN1B, CUL2, CUL3, CUL4A, CUL5, CUL7.

    Alternative splice isoforms for COMMD4 Gene


neXtProt entry for COMMD4 Gene

Proteomics data for COMMD4 Gene at MOPED

Post-translational modifications for COMMD4 Gene

  • Ubiquitination at Lys50, Lys113, and Lys180
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for COMMD4 Gene

Domains for COMMD4 Gene

Protein Domains for COMMD4 Gene


Suggested Antigen Peptide Sequences for COMMD4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9H0A8
  • Contains 1 COMM domain.
genes like me logo Genes that share domains with COMMD4: view

No data available for Gene Families for COMMD4 Gene

Function for COMMD4 Gene

Molecular function for COMMD4 Gene

UniProtKB/Swiss-Prot Function: May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Down-regulates activation of NF-kappa-B.

Gene Ontology (GO) - Molecular Function for COMMD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15799966
genes like me logo Genes that share ontologies with COMMD4: view

Phenotypes for COMMD4 Gene

GenomeRNAi human phenotypes for COMMD4:
genes like me logo Genes that share phenotypes with COMMD4: view

Animal Model Products

CRISPR Products

miRNA for COMMD4 Gene

miRTarBase miRNAs that target COMMD4

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for COMMD4 Gene

Localization for COMMD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COMMD4 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for COMMD4 Gene COMPARTMENTS Subcellular localization image for COMMD4 gene
Compartment Confidence
extracellular 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for COMMD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with COMMD4: view

Pathways for COMMD4 Gene

SuperPathways for COMMD4 Gene

No Data Available

PCR Array Products

Gene Ontology (GO) - Biological Process for COMMD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with COMMD4: view

No data available for Pathways by source for COMMD4 Gene

Transcripts for COMMD4 Gene

Unigene Clusters for COMMD4 Gene

COMM domain containing 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COMMD4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COMMD4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
SP1: -
SP2: - -

Relevant External Links for COMMD4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COMMD4 Gene

mRNA expression in normal human tissues for COMMD4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COMMD4 Gene

SOURCE GeneReport for Unigene cluster for COMMD4 Gene Hs.351327

mRNA Expression by UniProt/SwissProt for COMMD4 Gene

Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with COMMD4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for COMMD4 Gene

Orthologs for COMMD4 Gene

This gene was present in the common ancestor of animals.

Orthologs for COMMD4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia COMMD4 35
  • 99.83 (n)
  • 99.5 (a)
  • 99 (a)
(Bos Taurus)
Mammalia COMMD4 35
  • 87.77 (n)
  • 89.95 (a)
  • 90 (a)
(Canis familiaris)
Mammalia COMMD4 35
  • 91.29 (n)
  • 93.97 (a)
  • 94 (a)
(Mus musculus)
Mammalia Commd4 35
  • 86.93 (n)
  • 90.95 (a)
Commd4 16
Commd4 36
  • 91 (a)
(Monodelphis domestica)
Mammalia COMMD4 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia COMMD4 36
  • 75 (a)
(Rattus norvegicus)
Mammalia Commd4 35
  • 85.88 (n)
  • 88.7 (a)
(Gallus gallus)
Aves COMMD4 35
  • 73.23 (n)
  • 73.23 (a)
  • 73 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15129 35
tropical clawed frog
(Silurana tropicalis)
Amphibia commd4 35
  • 67.68 (n)
  • 68.02 (a)
Str.7325 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9443 35
(Danio rerio)
Actinopterygii commd4 35
  • 69.03 (n)
  • 74.8 (a)
commd4 36
  • 66 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001207 35
  • 48.85 (n)
  • 37.57 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG34039 35
  • 45.45 (n)
  • 36.9 (a)
CG34039 36
  • 34 (a)
Species with no ortholog for COMMD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COMMD4 Gene

Gene Tree for COMMD4 (if available)
Gene Tree for COMMD4 (if available)

Paralogs for COMMD4 Gene Pseudogenes for COMMD4 Gene

genes like me logo Genes that share paralogs with COMMD4: view

No data available for Paralogs for COMMD4 Gene

Variants for COMMD4 Gene

Sequence variations from dbSNP and Humsavar for COMMD4 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs3803465 -- 75,340,019(+) GTGTT(A/C)CAGGC utr-variant-3-prime, nc-transcript-variant
rs3809547 -- 75,336,500(+) CTCTT(C/G)CACAC intron-variant
rs3901343 -- 75,339,009(+) CACAG(G/T)GGCAG missense, reference, nc-transcript-variant, intron-variant
rs4310817 -- 75,335,297(+) TTTTT(C/G)TTGTT upstream-variant-2KB
rs4558385 -- 75,338,647(+) ATAGT(A/G)TGAGA reference, missense, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for COMMD4 Gene

Variant ID Type Subtype PubMed ID
esv2749894 CNV Deletion 23290073

Relevant External Links for COMMD4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COMMD4 Gene

Disorders for COMMD4 Gene

No disorders were found for COMMD4 Gene.

No data available for UniProtKB/Swiss-Prot for COMMD4 Gene

Publications for COMMD4 Gene

  1. COMMD proteins, a novel family of structural and functional homologs of MURR1. (PMID: 15799966) Burstein E. … Duckett C.S. (J. Biol. Chem. 2005) 2 3 4
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PMID: 11256614) Simpson J.C. … Wiemann S. (EMBO Rep. 2000) 3

Products for COMMD4 Gene

  • antibodies-online proteins for COMMD4
  • antibodies-online antibodies for COMMD4
  • antibodies-online kits for COMMD4

Sources for COMMD4 Gene

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