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Aliases for COMMD4 Gene

Aliases for COMMD4 Gene

  • COMM Domain Containing 4 2 3 5

External Ids for COMMD4 Gene

Previous GeneCards Identifiers for COMMD4 Gene

  • GC15P073345
  • GC15P073415
  • GC15P075628
  • GC15P052386

Summaries for COMMD4 Gene

GeneCards Summary for COMMD4 Gene

COMMD4 (COMM Domain Containing 4) is a Protein Coding gene.

UniProtKB/Swiss-Prot for COMMD4 Gene

  • May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Down-regulates activation of NF-kappa-B.

Gene Wiki entry for COMMD4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COMMD4 Gene

Genomics for COMMD4 Gene

Regulatory Elements for COMMD4 Gene

Enhancers for COMMD4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around COMMD4 on UCSC Golden Path with GeneCards custom track

Promoters for COMMD4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for COMMD4 Gene

Chromosome:
15
Start:
75,335,891 bp from pter
End:
75,343,224 bp from pter
Size:
7,334 bases
Orientation:
Plus strand

Genomic View for COMMD4 Gene

Genes around COMMD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COMMD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COMMD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COMMD4 Gene

Proteins for COMMD4 Gene

  • Protein details for COMMD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0A8-COMD4_HUMAN
    Recommended name:
    COMM domain-containing protein 4
    Protein Accession:
    Q9H0A8
    Secondary Accessions:
    • B2RBN4
    • H3BUL2
    • Q7L637
    • Q9NX43

    Protein attributes for COMMD4 Gene

    Size:
    199 amino acids
    Molecular mass:
    21764 Da
    Quaternary structure:
    • Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with RELA, RELB, NFKB1/p105. Interacts with CCDC22, CCDC93, SCNN1B, CUL2, CUL3, CUL4A, CUL5, CUL7.

    Alternative splice isoforms for COMMD4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COMMD4 Gene

Post-translational modifications for COMMD4 Gene

  • Ubiquitination at Lys 50 and Lys 180
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for COMMD4 Gene

Domains & Families for COMMD4 Gene

Gene Families for COMMD4 Gene

Protein Domains for COMMD4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for COMMD4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H0A8

UniProtKB/Swiss-Prot:

COMD4_HUMAN :
  • Contains 1 COMM domain.
Domain:
  • Contains 1 COMM domain.
genes like me logo Genes that share domains with COMMD4: view

Function for COMMD4 Gene

Molecular function for COMMD4 Gene

UniProtKB/Swiss-Prot Function:
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Down-regulates activation of NF-kappa-B.

Gene Ontology (GO) - Molecular Function for COMMD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15799966
genes like me logo Genes that share ontologies with COMMD4: view
genes like me logo Genes that share phenotypes with COMMD4: view

Animal Model Products

CRISPR Products

miRNA for COMMD4 Gene

miRTarBase miRNAs that target COMMD4

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COMMD4 Gene

Localization for COMMD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COMMD4 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COMMD4 Gene COMPARTMENTS Subcellular localization image for COMMD4 gene
Compartment Confidence
nucleus 4
extracellular 2
cytosol 1

Gene Ontology (GO) - Cellular Components for COMMD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with COMMD4: view

Pathways & Interactions for COMMD4 Gene

SuperPathways for COMMD4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for COMMD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with COMMD4: view

No data available for Pathways by source and SIGNOR curated interactions for COMMD4 Gene

Drugs & Compounds for COMMD4 Gene

No Compound Related Data Available

Transcripts for COMMD4 Gene

Unigene Clusters for COMMD4 Gene

COMM domain containing 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COMMD4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
SP1: -
SP2: - -
SP3:

Relevant External Links for COMMD4 Gene

GeneLoc Exon Structure for
COMMD4
ECgene alternative splicing isoforms for
COMMD4

Expression for COMMD4 Gene

mRNA expression in normal human tissues for COMMD4 Gene

Protein differential expression in normal tissues from HIPED for COMMD4 Gene

This gene is overexpressed in Bone (8.9), Peripheral blood mononuclear cells (8.7), and Lymph node (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for COMMD4 Gene



Protein tissue co-expression partners for COMMD4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of COMMD4 Gene:

COMMD4

SOURCE GeneReport for Unigene cluster for COMMD4 Gene:

Hs.351327

mRNA Expression by UniProt/SwissProt for COMMD4 Gene:

Q9H0A8-COMD4_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with COMMD4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for COMMD4 Gene

Orthologs for COMMD4 Gene

This gene was present in the common ancestor of animals.

Orthologs for COMMD4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia COMMD4 34
  • 87.77 (n)
  • 89.95 (a)
COMMD4 35
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COMMD4 34
  • 91.29 (n)
  • 93.97 (a)
COMMD4 35
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Commd4 34
  • 86.93 (n)
  • 90.95 (a)
Commd4 16
Commd4 35
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia COMMD4 34
  • 99.83 (n)
  • 99.5 (a)
COMMD4 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Commd4 34
  • 85.88 (n)
  • 88.7 (a)
oppossum
(Monodelphis domestica)
Mammalia COMMD4 35
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COMMD4 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves COMMD4 34
  • 73.23 (n)
  • 73.23 (a)
COMMD4 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia commd4 34
  • 67.68 (n)
  • 68.02 (a)
Str.7325 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.15129 34
zebrafish
(Danio rerio)
Actinopterygii commd4 34
  • 69.03 (n)
  • 74.8 (a)
commd4 35
  • 66 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9443 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001207 34
  • 48.85 (n)
  • 37.57 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG34039 34
  • 45.45 (n)
  • 36.9 (a)
CG34039 35
  • 34 (a)
OneToOne
Species where no ortholog for COMMD4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COMMD4 Gene

ENSEMBL:
Gene Tree for COMMD4 (if available)
TreeFam:
Gene Tree for COMMD4 (if available)

Paralogs for COMMD4 Gene

Pseudogenes.org Pseudogenes for COMMD4 Gene

genes like me logo Genes that share paralogs with COMMD4: view

No data available for Paralogs for COMMD4 Gene

Variants for COMMD4 Gene

Sequence variations from dbSNP and Humsavar for COMMD4 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs3803465 -- 75,340,019(+) GTGTT(A/C)CAGGC nc-transcript-variant, utr-variant-3-prime
rs3809547 -- 75,336,500(+) CTCTT(C/G)CACAC intron-variant
rs3901343 -- 75,339,009(+) CACAG(G/T)GGCAG intron-variant, nc-transcript-variant, reference, missense
rs4310817 -- 75,335,297(+) TTTTT(C/G)TTGTT upstream-variant-2KB
rs4558385 -- 75,338,647(+) ATAGT(A/G)TGAGA nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for COMMD4 Gene

Variant ID Type Subtype PubMed ID
dgv2621n100 CNV gain 25217958
esv2749894 CNV deletion 23290073
nsv1116463 OTHER inversion 24896259
nsv977736 CNV duplication 23825009

Variation tolerance for COMMD4 Gene

Residual Variation Intolerance Score: 52.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COMMD4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
COMMD4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COMMD4 Gene

Disorders for COMMD4 Gene

Relevant External Links for COMMD4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COMMD4

No disorders were found for COMMD4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COMMD4 Gene

Publications for COMMD4 Gene

  1. COMMD proteins, a novel family of structural and functional homologs of MURR1. (PMID: 15799966) Burstein E. … Duckett C.S. (J. Biol. Chem. 2005) 2 3 4 65
  2. COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A. (PMID: 25355947) Phillips-Krawczak C.A. … Burstein E. (Mol. Biol. Cell 2015) 3 4 65
  3. CCDC22 deficiency in humans blunts activation of proinflammatory NF-I_B signaling. (PMID: 23563313) Starokadomskyy P. … Burstein E. (J. Clin. Invest. 2013) 3 4 65
  4. COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding. (PMID: 21778237) Mao X. … Burstein E. (J. Biol. Chem. 2011) 3 4 65
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65

Products for COMMD4 Gene

Sources for COMMD4 Gene

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