Free for academic non-profit institutions. Other users need a Commercial license

Aliases for COMMD4 Gene

Aliases for COMMD4 Gene

  • COMM Domain Containing 4 2 3 5

External Ids for COMMD4 Gene

Previous GeneCards Identifiers for COMMD4 Gene

  • GC15P073345
  • GC15P073415
  • GC15P075628
  • GC15P052386

Summaries for COMMD4 Gene

GeneCards Summary for COMMD4 Gene

COMMD4 (COMM Domain Containing 4) is a Protein Coding gene.

UniProtKB/Swiss-Prot for COMMD4 Gene

  • May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Down-regulates activation of NF-kappa-B.

Gene Wiki entry for COMMD4 Gene

Additional gene information for COMMD4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COMMD4 Gene

Genomics for COMMD4 Gene

Regulatory Elements for COMMD4 Gene

Enhancers for COMMD4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H074380 2 FANTOM5 Ensembl ENCODE dbSUPER 22.6 -943.2 -943231 24.1 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A ZNF2 SLC30A9 ZNF766 EDC3 COMMD4 SEMA7A LOC101929333 CLK3 ENSG00000212279 ANP32BP1 LOXL1 ENSG00000260274 CYP11A1
GH15H075366 1.2 ENCODE 31.3 +32.9 32864 3.8 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A SIN3A DNM1P35 EDC3 MAN2C1 LOC441728 SNUPN FBXO22 COMMD4 ENSG00000260274 ENSG00000203392
GH15H074539 1.8 FANTOM5 Ensembl ENCODE 19.3 -793.9 -793931 4.1 HDGF PKNOX1 ARID4B SIN3A FEZF1 ZNF2 ZBTB7B YY1 ZNF143 ZNF207 SIN3A MAN2C1 EDC3 ENSG00000260274 ISLR UBL7-AS1 COMMD4 UBL7 DNM1P34 LOC732265
GH15H075449 1.8 FANTOM5 ENCODE dbSUPER 14.9 +117.5 117466 8.1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC MAN2C1 ENSG00000260274 SIN3A SNUPN DNM1P34 EDC3 FBXO22 LOC105370902 COMMD4 GOLGA6D
GH15H074768 1.2 Ensembl ENCODE 20.3 -566.9 -566890 0.5 PKNOX1 ATF1 SIN3A GLIS2 ZNF143 REST ZNF518A ZNF292 ZNF610 GLIS1 MAN2C1 SIN3A ENSG00000260274 EDC3 ENSG00000203392 CLK3 PML DNM1P35 COMMD4 SNX33
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around COMMD4 on UCSC Golden Path with GeneCards custom track

Promoters for COMMD4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for COMMD4 Gene

Genomic Locations for COMMD4 Gene
7,334 bases
Plus strand

Genomic View for COMMD4 Gene

Genes around COMMD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COMMD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COMMD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COMMD4 Gene

Proteins for COMMD4 Gene

  • Protein details for COMMD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    COMM domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • B2RBN4
    • H3BUL2
    • Q7L637
    • Q9NX43

    Protein attributes for COMMD4 Gene

    199 amino acids
    Molecular mass:
    21764 Da
    Quaternary structure:
    • Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with RELA, RELB, NFKB1/p105. Interacts with CCDC22, CCDC93, SCNN1B, CUL2, CUL3, CUL4A, CUL5, CUL7.

    Alternative splice isoforms for COMMD4 Gene


neXtProt entry for COMMD4 Gene

Post-translational modifications for COMMD4 Gene

  • Ubiquitination at posLast=5050 and posLast=180180
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for COMMD4 Gene

Domains & Families for COMMD4 Gene

Gene Families for COMMD4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for COMMD4 Gene


Suggested Antigen Peptide Sequences for COMMD4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with COMMD4: view

No data available for UniProtKB/Swiss-Prot for COMMD4 Gene

Function for COMMD4 Gene

Molecular function for COMMD4 Gene

UniProtKB/Swiss-Prot Function:
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Down-regulates activation of NF-kappa-B.

Phenotypes From GWAS Catalog for COMMD4 Gene

Gene Ontology (GO) - Molecular Function for COMMD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15799966
genes like me logo Genes that share ontologies with COMMD4: view
genes like me logo Genes that share phenotypes with COMMD4: view

Animal Model Products

miRNA for COMMD4 Gene

miRTarBase miRNAs that target COMMD4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COMMD4 Gene

Localization for COMMD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COMMD4 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for COMMD4 gene
Compartment Confidence
nucleus 4
extracellular 2
cytosol 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for COMMD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with COMMD4: view

Pathways & Interactions for COMMD4 Gene

SuperPathways for COMMD4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for COMMD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with COMMD4: view

No data available for Pathways by source and SIGNOR curated interactions for COMMD4 Gene

Drugs & Compounds for COMMD4 Gene

No Compound Related Data Available

Transcripts for COMMD4 Gene

Unigene Clusters for COMMD4 Gene

COMM domain containing 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for COMMD4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
SP1: -
SP2: - -

Relevant External Links for COMMD4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COMMD4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for COMMD4 Gene

Protein differential expression in normal tissues from HIPED for COMMD4 Gene

This gene is overexpressed in Bone (8.9), Peripheral blood mononuclear cells (8.7), and Lymph node (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for COMMD4 Gene

Protein tissue co-expression partners for COMMD4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of COMMD4 Gene:


SOURCE GeneReport for Unigene cluster for COMMD4 Gene:


mRNA Expression by UniProt/SwissProt for COMMD4 Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for COMMD4 Gene

  • Nervous system(3.4)
genes like me logo Genes that share expression patterns with COMMD4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for COMMD4 Gene

Orthologs for COMMD4 Gene

This gene was present in the common ancestor of animals.

Orthologs for COMMD4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia COMMD4 33 34
  • 99.83 (n)
(Canis familiaris)
Mammalia COMMD4 33 34
  • 91.29 (n)
(Bos Taurus)
Mammalia COMMD4 33 34
  • 87.77 (n)
(Mus musculus)
Mammalia Commd4 33 16 34
  • 86.93 (n)
(Rattus norvegicus)
Mammalia Commd4 33
  • 85.88 (n)
(Monodelphis domestica)
Mammalia COMMD4 34
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia COMMD4 34
  • 75 (a)
(Gallus gallus)
Aves COMMD4 33 34
  • 73.23 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia commd4 33
  • 67.68 (n)
Str.7325 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.15129 33
(Danio rerio)
Actinopterygii commd4 33 34
  • 69.03 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9443 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001207 33
  • 48.85 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG34039 33 34
  • 45.45 (n)
Species where no ortholog for COMMD4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COMMD4 Gene

Gene Tree for COMMD4 (if available)
Gene Tree for COMMD4 (if available)

Paralogs for COMMD4 Gene Pseudogenes for COMMD4 Gene

genes like me logo Genes that share paralogs with COMMD4: view

No data available for Paralogs for COMMD4 Gene

Variants for COMMD4 Gene

Sequence variations from dbSNP and Humsavar for COMMD4 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000233675 -- 75,334,743(+) GCTGC(A/C)CCTGT upstream-variant-2KB
rs1000302644 -- 75,339,554(+) GGGCA(C/T)CTGCC intron-variant
rs1000694685 -- 75,338,291(+) TCTGA(C/G)CCAGT intron-variant
rs1000890935 -- 75,338,466(+) TGACC(A/C)CCACT intron-variant
rs1002030519 -- 75,341,401(+) GGCTT(G/T)TTCCA nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for COMMD4 Gene

Variant ID Type Subtype PubMed ID
nsv977736 CNV duplication 23825009
nsv1116463 OTHER inversion 24896259
esv2749894 CNV deletion 23290073
dgv2621n100 CNV gain 25217958

Variation tolerance for COMMD4 Gene

Residual Variation Intolerance Score: 52.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COMMD4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COMMD4 Gene

Disorders for COMMD4 Gene

Relevant External Links for COMMD4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for COMMD4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COMMD4 Gene

Publications for COMMD4 Gene

  1. COMMD proteins, a novel family of structural and functional homologs of MURR1. (PMID: 15799966) Burstein E … Duckett CS (The Journal of biological chemistry 2005) 2 3 4 60
  2. COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A. (PMID: 25355947) Phillips-Krawczak CA … Burstein E (Molecular biology of the cell 2015) 3 4 60
  3. CCDC22 deficiency in humans blunts activation of proinflammatory NF-κB signaling. (PMID: 23563313) Starokadomskyy P … Burstein E (The Journal of clinical investigation 2013) 3 4 60
  4. COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding. (PMID: 21778237) Mao X … Burstein E (The Journal of biological chemistry 2011) 3 4 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60

Products for COMMD4 Gene

Sources for COMMD4 Gene

Loading form....