COMMD4 Gene
protein-coding GIFtS: 45
GCID: GC15P075628
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|
COMM domain containing 4
| |
Aliases
for COMMD4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| COMM Domain Containing 41 2 | | FLJ204521 | | COMM Domain-Containing Protein 42 |
Export aliases for COMMD4 gene to outside databasesPrevious GC identifers: GC15P073345 GC15P073415 GC15P052386 |
Summaries
for COMMD4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: COMD4_HUMAN, Q9H0A8Function: Down-regulates activation of NF-kappa-B
Gene Wiki entry for COMMD4
|
Genomic Views
for COMMD4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the COMMD4 gene promoter:
AhR GATA-3 RelA NF-kappaB Arnt CREB FOXO4 deltaCREB Zic3 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for COMMD4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COMMD4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q24.2 Ensembl cytogenetic band: 15q24.2 HGNC cytogenetic band: 15q24.2COMMD4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P075628: view genomic region
(about GC identifiers)
Start:
|
75,628,232 bp from pter |
End:
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75,634,268 bp from pter |
Size:
|
6,037 bases |
Orientation:
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plus strand |
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Proteins
for COMMD4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: COMD4_HUMAN, Q9H0A8 (See
protein sequence)Recommended Name: COMM domain-containing protein 4 Size: 199 amino acids; 21764 Da
Subunit: Interacts (via COMM domain) with COMMD1 (via COMM domain)
Secondary accessions: B2RBN4 Q7L637 Q9NX43Alternative splicing: 2 isoforms: Q9H0A8-1 Q9H0A8-2 Explore the universe of human proteins at neXtProt for COMMD4: NX_Q9H0A8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H0A8
COMMD4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060298.2
ENSEMBL proteins: ENSP00000267935 ENSP00000457693 ENSP00000455249 ENSP00000456440 ENSP00000340867 ENSP00000457348 ENSP00000433662 ENSP00000455303 ENSP00000455750 ENSP00000454283
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IDA | -- |
COMMD4 for ontologies About GeneDecksing
COMMD4 Antibody Products:
Assay Products for COMMD4: |
Protein
Domains /
Families
for COMMD4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
COMMD4 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H0A8ProtoNet protein and cluster: Q9H0A8 1 Blocks protein family: IPB009886 HCaRG
UniProtKB/Swiss-Prot: COMD4_HUMAN, Q9H0A8Similarity: Contains 1 COMM domain |
Function
for COMMD4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: COMD4_HUMAN, Q9H0A8Function: Down-regulates activation of NF-kappa-B
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: COMMD4 (NM_017828) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COMMD4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COMMD4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COMMD4 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
COMMD4 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for COMMD4:
|
Pathways & Interactions
for COMMD4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for COMMD4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/6 Interacting proteins for COMMD4 (Q9H0A81, 3 ENSP000002679354) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
|
Drugs & Compounds
for COMMD4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for COMMD4
Search CenterWatch for drugs/clinical trials and news about COMMD4 / COMD4
|
Transcripts
for COMMD4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for COMMD4 gene: NM_017828.3 Unigene Cluster for COMMD4: COMM domain containing 4 Hs.741298 [show with all ESTs]Unigene Representative Sequence: AK12496818/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25): ENST00000267935(uc002azy.3 uc002azz.3 uc002baa.3) ENST00000567195
ENST00000566843(uc010umf.1 uc010umg.2) ENST00000564815 ENST00000562610
ENST00000338995 ENST00000567023 ENST00000567720 ENST00000566230 ENST00000564587
ENST00000565517 ENST00000564068 ENST00000480484 ENST00000567399 ENST00000561662
ENST00000568034 ENST00000567377 ENST00000562789
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: COMMD4 (NM_017828) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COMMD4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COMMD4 |
Additional cDNA sequence: AK000459.1 AK057145.1 AK124968.1 AK225716.1 AK293708.1 AK314740.1 AY542160.1 BC000837.2 BC033744.1 BC040944.2 BC068998.1 BC069195.1 CR533452.1 24/25 DOTS entries (see all 25): DT.91922733 DT.91754427 DT.97864304 DT.100797207 DT.91754414 DT.91754426 DT.121052633 DT.121052934 DT.121052643 DT.121052632 DT.455253 DT.101984562 DT.100797208 DT.91916484 DT.121052920 DT.102839746 DT.91754435 DT.100833559 DT.121052978 DT.91754422 DT.95256477 DT.97864303 DT.100763886 DT.100797202 24/324 AceView cDNA sequences (see all 324): AW069258 BM790098 AI802436 AA758998 CA309263 CB123816 BU752821 AI217934 AA429906 BQ433106 BM982563 BU731896 BM817514 BE858465 BQ671139 BM972849 BI829484 AI083877 NM_017828 AA715088 BQ962103 AI868792 AW027633 AI148280
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for COMMD4 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c |
|---|
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| SP1: | | | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for COMMD4
|
Expression
for COMMD4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| COMMD4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCCTCTCAG
About this image
See COMMD4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for COMMD4
SOURCE GeneReport for Unigene cluster: Hs.741298
UniProtKB/Swiss-Prot: COMD4_HUMAN, Q9H0A8Tissue specificity: Ubiquitous
SABiosciences Expression via Pathway-Focused PCR Arrays including COMMD4:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COMMD4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat COMMD4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COMMD4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COMMD4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COMMD4 |
Orthologs
for COMMD4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for COMMD4 gene from 5/21 species (see all 21) About this table
ENSEMBL Gene Tree for COMMD4 (if available)
TreeFam Gene Tree for COMMD4 (if available) |
Paralogs
for COMMD4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for COMMD4 gene
COMMD4 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for COMMD4
PGOHUM00000262228 PGOHUM00000262229 PGOHUM00000262256
|
Genomic Variants
for COMMD4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for COMMD4 (75628232 - 75634268 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for COMMD4: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COMMD4 |
|
Disorders
/ Diseases
for COMMD4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for COMMD4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for COMMD4 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with COMMD4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- COMMD proteins, a novel family of structural and functional homologs of MURR1. (PubMed id 15799966)1, 2, 3 Burstein E....Duckett C.S. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
- Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
|
External Searches for COMMD4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing COMMD4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing COMMD4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing COMMD4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for COMMD4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for COMMD4 gene:
Search GeneIP for patents involving COMMD4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for COMMD4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for COMMD4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COMMD4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COMMD4 | | | OriGene Protein Over-expression Lysate for COMMD4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for COMMD4 | | OriGene 3'-UTR Clone for COMMD4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for COMMD4 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for COMMD4 | | OriGene Custom Protein Services for COMMD4 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat COMMD4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COMMD4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COMMD4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COMMD4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COMMD4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COMMD4 |
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 |  |  |  | |
| | | | Search Tocris compounds for COMMD4 |
| |  |  |  |  | | | | |
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 |
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 | | | COMMD4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COMMD4 |
|  |  |  | | | | Search ThermoFisher Antibodies for COMMD4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COMMD4 |
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