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Aliases for COMMD3-BMI1 Gene

Aliases for COMMD3-BMI1 Gene

  • COMMD3-BMI1 Readthrough 2 3

External Ids for COMMD3-BMI1 Gene

Previous GeneCards Identifiers for COMMD3-BMI1 Gene

  • GC10U901532
  • GC10P022606
  • GC10P022607

Summaries for COMMD3-BMI1 Gene

Entrez Gene Summary for COMMD3-BMI1 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring COMM domain-containing protein 3 and polycomb complex protein BMI-1 genes on chromosome 10. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Feb 2011]

GeneCards Summary for COMMD3-BMI1 Gene

COMMD3-BMI1 (COMMD3-BMI1 Readthrough) is a Protein Coding gene. Among its related pathways are MicroRNAs in cancer and Transcriptional misregulation in cancer. An important paralog of this gene is BMI1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COMMD3-BMI1 Gene

Genomics for COMMD3-BMI1 Gene

Genomic Location for COMMD3-BMI1 Gene

Start:
22,316,383 bp from pter
End:
22,331,485 bp from pter
Size:
15,103 bases
Orientation:
Plus strand

Genomic View for COMMD3-BMI1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COMMD3-BMI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COMMD3-BMI1 Gene

No data available for Regulatory Elements for COMMD3-BMI1 Gene

Proteins for COMMD3-BMI1 Gene

  • Protein details for COMMD3-BMI1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Q5T8Z1
    Recommended name:
    Protein COMMD3-BMI1
    Protein Accession:
    Q5T8Z1
    Secondary Accessions:

    Protein attributes for COMMD3-BMI1 Gene

    Size:
    53 amino acids
    Molecular mass:
    5961 Da
    Quaternary structure:
    No Data Available
  • Protein details for COMMD3-BMI1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    R4GMW6
    Recommended name:
    Protein COMMD3-BMI1
    Protein Accession:
    R4GMW6
    Secondary Accessions:

    Protein attributes for COMMD3-BMI1 Gene

    Size:
    159 amino acids
    Molecular mass:
    18133 Da
    Quaternary structure:
    No Data Available
  • Protein details for COMMD3-BMI1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    R4GMX3
    Recommended name:
    Protein COMMD3-BMI1
    Protein Accession:
    R4GMX3
    Secondary Accessions:

    Protein attributes for COMMD3-BMI1 Gene

    Size:
    469 amino acids
    Molecular mass:
    53294 Da
    Quaternary structure:
    No Data Available
  • Protein details for COMMD3-BMI1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    R4GN54
    Recommended name:
    Protein COMMD3-BMI1
    Protein Accession:
    R4GN54
    Secondary Accessions:

    Protein attributes for COMMD3-BMI1 Gene

    Size:
    110 amino acids
    Molecular mass:
    12329 Da
    Quaternary structure:
    No Data Available

neXtProt entry for COMMD3-BMI1 Gene

Proteomics data for COMMD3-BMI1 Gene at MOPED

Post-translational modifications for COMMD3-BMI1 Gene

No Post-translational modifications

Other Protein References for COMMD3-BMI1 Gene

No data available for DME Specific Peptides for COMMD3-BMI1 Gene

Domains for COMMD3-BMI1 Gene

Protein Domains for COMMD3-BMI1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with COMMD3-BMI1: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for COMMD3-BMI1 Gene

Function for COMMD3-BMI1 Gene

Gene Ontology (GO) - Molecular Function for COMMD3-BMI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding --
GO:0046872 metal ion binding --
GO:0071535 RING-like zinc finger domain binding --
genes like me logo Genes that share ontologies with COMMD3-BMI1: view

Animal Model Products

miRNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for COMMD3-BMI1 Gene

Localization for COMMD3-BMI1 Gene

Gene Ontology (GO) - Cellular Components for COMMD3-BMI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex --
GO:0005634 nucleus --
GO:0005654 nucleoplasm --
GO:0005737 cytoplasm --
GO:0031519 PcG protein complex --
genes like me logo Genes that share ontologies with COMMD3-BMI1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for COMMD3-BMI1 Gene

Pathways for COMMD3-BMI1 Gene

genes like me logo Genes that share pathways with COMMD3-BMI1: view

Pathways by source for COMMD3-BMI1 Gene

Interacting Proteins for COMMD3-BMI1 Gene

Selected Interacting proteins: Q5T8Z1 for COMMD3-BMI1 Gene via I2D

Gene Ontology (GO) - Biological Process for COMMD3-BMI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter --
GO:0006351 transcription, DNA-templated --
GO:0007379 segment specification --
GO:0010468 regulation of gene expression --
GO:0016568 chromatin modification --
genes like me logo Genes that share ontologies with COMMD3-BMI1: view

Transcripts for COMMD3-BMI1 Gene

mRNA/cDNA for COMMD3-BMI1 Gene

(1) REFSEQ mRNAs :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COMMD3-BMI1 Gene

No ASD Table

Relevant External Links for COMMD3-BMI1 Gene

GeneLoc Exon Structure for
COMMD3-BMI1
ECgene alternative splicing isoforms for
COMMD3-BMI1

Expression for COMMD3-BMI1 Gene

mRNA expression in normal human tissues for COMMD3-BMI1 Gene

Protein differential expression in normal tissues for COMMD3-BMI1 Gene

This gene is overexpressed in Retina (19.8), Blymphocyte (15.6), CD8 Tcells (8.6), and Fetal ovary (6.6).

Integrated Proteomics: protein expression from for COMMD3-BMI1 Gene

genes like me logo Genes that share expressions with COMMD3-BMI1: view

Expression partners for COMMD3-BMI1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for COMMD3-BMI1 Gene

Orthologs for COMMD3-BMI1 Gene

This gene was present in the common ancestor of animals.

Orthologs for COMMD3-BMI1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BMI1 35
  • 95.91 (n)
  • 99.08 (a)
BMI1 36
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia BMI1 35
  • 95.09 (n)
  • 98.77 (a)
BMI1 36
  • 99 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Bmi1 35
  • 92.59 (n)
  • 97.53 (a)
Bmi1 36
  • 98 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Bmi1 35
  • 89.61 (n)
  • 95.37 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 82 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 98 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 100 (a)
OneToMany
chicken
(Gallus gallus)
Aves BMI1 35
  • 78.83 (n)
  • 95.4 (a)
BMI1 36
  • 95 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 88 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia bmi1 35
  • 77.98 (n)
  • 89.81 (a)
zebrafish
(Danio rerio)
Actinopterygii bmi1b 35
  • 72.41 (n)
  • 78.68 (a)
bmi1a 36
  • 82 (a)
ManyToMany
bmi1b 36
  • 77 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Psc 36
  • 8 (a)
ManyToMany
Su(z)2 36
  • 7 (a)
ManyToMany
Species with no ortholog for COMMD3-BMI1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COMMD3-BMI1 Gene

ENSEMBL:
Gene Tree for COMMD3-BMI1 (if available)
TreeFam:
Gene Tree for COMMD3-BMI1 (if available)

Paralogs for COMMD3-BMI1 Gene

Paralogs for COMMD3-BMI1 Gene

Selected SIMAP similar genes for COMMD3-BMI1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with COMMD3-BMI1: view

Variants for COMMD3-BMI1 Gene

Structural Variations from Database of Genomic Variants (DGV) for COMMD3-BMI1 Gene

Variant ID Type Subtype PubMed ID
dgv136n67 CNV Gain 20364138
dgv137n67 CNV Gain 20364138
dgv624n71 CNV Loss 21882294
dgv625n71 CNV Loss 21882294
nsv894959 CNV Loss 21882294
esv27808 CNV Gain 19812545
nsv825300 CNV Gain 20364138

Relevant External Links for COMMD3-BMI1 Gene

HapMap Linkage Disequilibrium report
COMMD3-BMI1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for COMMD3-BMI1 Gene

Disorders for COMMD3-BMI1 Gene

No disorders were found for COMMD3-BMI1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for COMMD3-BMI1 Gene

Publications for COMMD3-BMI1 Gene

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3

Products for COMMD3-BMI1 Gene

Sources for COMMD3-BMI1 Gene

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