COMMD3-BMI1 Gene
protein-coding GIFtS: 11
GCID: GC10U901532
|
|
COMMD3-BMI1
| |
Aliases for COMMD3-BMI1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| COMMD3-BMI1 Read-Through Protein2 | | COMMD3-BMI1 Readthrough2 |
Export aliases for COMMD3-BMI1 gene to outside databases |
Summaries for COMMD3-BMI1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for COMMD3-BMI1: This locus represents naturally occurring read-through transcription between the neighboring COMM domain-containingprotein 3 and polycomb complex protein BMI-1 genes on chromosome 10. The read-through transcript produces a fusionprotein that shares sequence identity with each individual gene product. (provided by RefSeq, Feb 2011)
|
Genomic Views for COMMD3-BMI1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for COMMD3-BMI1 Other transcription factors
Search SABiosciences Chromatin IP Primers for COMMD3-BMI1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COMMD3-BMI1 |
Genomic Location: Chromosome:10
GeneLoc information about chromosome 10 |
Proteins for COMMD3-BMI1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB: -- COMMD3-BMI1 Protein expression data from MOPED and PaxDb: -- REFSEQ proteins: NP_001190991.1 Human Recombinant Protein Products: Antibody Products for COMMD3-BMI1: Assay Products for COMMD3-BMI1: |
Protein
Domains / Families for COMMD3-BMI1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| -- |
Function for COMMD3-BMI1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COMMD3-BMI1 |
|
Pathways & Interactions for COMMD3-BMI1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Senescence and Autophagy | | | 2 | Validated targets of C-MYC transcriptional activation | |
2 BioSystems Pathways for COMMD3-BMI1 
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for COMMD3-BMI1
|
Drugs & Compounds for COMMD3-BMI1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for COMMD3-BMI1 Search CenterWatch for drugs/clinical trials and news about COMMD3-BMI1 
|
Transcripts for COMMD3-BMI1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for COMMD3-BMI1 gene: NM_001204062.1
|
Expression for COMMD3-BMI1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot CGAP TAG: -- SABiosciences Custom PCR Arrays for COMMD3-BMI1
Primer Products: |  | Browse OriGene genome-wide validated SYBR primer pairs Browse OriGene validated miRNA SYBR primer pairs
| |  | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat COMMD3-BMI1 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COMMD3-BMI1 | |  | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COMMD3-BMI1 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COMMD3-BMI1 |
Orthologs for COMMD3-BMI1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for COMMD3-BMI1 gene from 3/6 species (see all 6) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
mouse (Mus musculus) |
Mammalia |
Bmi11 |
Bmi1 polycomb ring finger oncogene |
92.59(n) 97.53(a) |
  |
12151 NM_007552.4 NP_031578.2 |
chicken (Gallus gallus) |
Aves |
BMI11 |
BMI1 polycomb ring finger oncogene |
78.83(n) 95.4(a) |
  |
493647 NM_001007988.1 NP_001007989.1 |
zebrafish (Danio rerio) |
Actinopterygii |
bmi1a1 |
B lymphoma Mo-MLV insertion region 1a |
73.44(n) 82.5(a) |
  |
321505 NM_194366.1 NP_919347.1 |
|
Paralogs for COMMD3-BMI1 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| -- |
Genomic Variants for COMMD3-BMI1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|  | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases for COMMD3-BMI1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications for COMMD3-BMI1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed article for COMMD3-BMI1 gene integrated from 9 sources: (articles sorted by number of sources associating them with COMMD3-BMI1) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (2010)
|
External Searches for COMMD3-BMI1 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing COMMD3-BMI1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing COMMD3-BMI1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing COMMD3-BMI1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
|
About This Section
| Patent Information for COMMD3-BMI1 gene: Search GeneIP for patents involving COMMD3-BMI1
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for COMMD3-BMI1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 |
| | | | |  |
 |
| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat COMMD3-BMI1 | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COMMD3-BMI1 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COMMD3-BMI1 | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COMMD3-BMI1 | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COMMD3-BMI1 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COMMD3-BMI1 |
| |
 |  |  |  | |
| | | |  |  |  |  | | | | |
 |
 |
 |
 | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COMMD3-BMI1 |
|  |  |  | | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat COMMD3-BMI1 |
|
|
|
|