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Aliases for COMMD3-BMI1 Gene

Aliases for COMMD3-BMI1 Gene

  • COMMD3-BMI1 Readthrough 2 3 5

External Ids for COMMD3-BMI1 Gene

Previous GeneCards Identifiers for COMMD3-BMI1 Gene

  • GC10U901532
  • GC10P022606
  • GC10P022607

Summaries for COMMD3-BMI1 Gene

Entrez Gene Summary for COMMD3-BMI1 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring COMM domain-containing protein 3 and polycomb complex protein BMI-1 genes on chromosome 10. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Feb 2011]

GeneCards Summary for COMMD3-BMI1 Gene

COMMD3-BMI1 (COMMD3-BMI1 Readthrough) is a Protein Coding gene. Among its related pathways are Signaling pathways regulating pluripotency of stem cells and Transcriptional misregulation in cancer. GO annotations related to this gene include RING-like zinc finger domain binding. An important paralog of this gene is BMI1.

Additional gene information for COMMD3-BMI1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COMMD3-BMI1 Gene

Genomics for COMMD3-BMI1 Gene

Regulatory Elements for COMMD3-BMI1 Gene

Enhancers for COMMD3-BMI1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H022313 1.1 ENCODE 0.7 -0.2 -199 6 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 MLLT10 COMMD3 COMMD3-BMI1
GH10H022319 1.1 ENCODE 0.7 +4.6 4645 2 PKNOX1 SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 ZNF143 ZNF207 SP3 BMI1 MLLT10 COMMD3-BMI1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around COMMD3-BMI1 on UCSC Golden Path with GeneCards custom track

Promoters for COMMD3-BMI1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000025448 217 2001 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for COMMD3-BMI1 Gene

Chromosome:
10
Start:
22,316,383 bp from pter
End:
22,331,485 bp from pter
Size:
15,103 bases
Orientation:
Plus strand

Genomic View for COMMD3-BMI1 Gene

Genes around COMMD3-BMI1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COMMD3-BMI1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COMMD3-BMI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COMMD3-BMI1 Gene

Proteins for COMMD3-BMI1 Gene

  • Protein details for COMMD3-BMI1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Q5T8Z1
    Recommended name:
    COMMD3-BMI1 readthrough
    Protein Accession:
    Q5T8Z1

    Protein attributes for COMMD3-BMI1 Gene

    Size:
    53 amino acids
    Molecular mass:
    5961 Da
    Quaternary structure:
    No Data Available
  • Protein details for COMMD3-BMI1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    R4GMW6
    Recommended name:
    COMMD3-BMI1 readthrough
    Protein Accession:
    R4GMW6

    Protein attributes for COMMD3-BMI1 Gene

    Size:
    159 amino acids
    Molecular mass:
    18133 Da
    Quaternary structure:
    No Data Available
  • Protein details for COMMD3-BMI1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    R4GMX3
    Recommended name:
    COMMD3-BMI1 readthrough
    Protein Accession:
    R4GMX3

    Protein attributes for COMMD3-BMI1 Gene

    Size:
    469 amino acids
    Molecular mass:
    53294 Da
    Quaternary structure:
    No Data Available
  • Protein details for COMMD3-BMI1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    R4GN54
    Recommended name:
    COMMD3-BMI1 readthrough
    Protein Accession:
    R4GN54

    Protein attributes for COMMD3-BMI1 Gene

    Size:
    110 amino acids
    Molecular mass:
    12329 Da
    Quaternary structure:
    No Data Available

neXtProt entry for COMMD3-BMI1 Gene

Post-translational modifications for COMMD3-BMI1 Gene

No Post-translational modifications

Other Protein References for COMMD3-BMI1 Gene

No data available for DME Specific Peptides for COMMD3-BMI1 Gene

Domains & Families for COMMD3-BMI1 Gene

Gene Families for COMMD3-BMI1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for COMMD3-BMI1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with COMMD3-BMI1: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for COMMD3-BMI1 Gene

Function for COMMD3-BMI1 Gene

Phenotypes From GWAS Catalog for COMMD3-BMI1 Gene

genes like me logo Genes that share phenotypes with COMMD3-BMI1: view

Animal Models for COMMD3-BMI1 Gene

MGI Knock Outs for COMMD3-BMI1:

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for COMMD3-BMI1 Gene

Localization for COMMD3-BMI1 Gene

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear bodies (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for COMMD3-BMI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with COMMD3-BMI1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for COMMD3-BMI1 Gene

Pathways & Interactions for COMMD3-BMI1 Gene

genes like me logo Genes that share pathways with COMMD3-BMI1: view

Pathways by source for COMMD3-BMI1 Gene

Interacting Proteins for COMMD3-BMI1 Gene

Gene Ontology (GO) - Biological Process for COMMD3-BMI1 Gene

None

No data available for SIGNOR curated interactions for COMMD3-BMI1 Gene

Drugs & Compounds for COMMD3-BMI1 Gene

No Compound Related Data Available

Transcripts for COMMD3-BMI1 Gene

mRNA/cDNA for COMMD3-BMI1 Gene

(1) REFSEQ mRNAs :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for COMMD3-BMI1 Gene

No ASD Table

Relevant External Links for COMMD3-BMI1 Gene

GeneLoc Exon Structure for
COMMD3-BMI1
ECgene alternative splicing isoforms for
COMMD3-BMI1

Expression for COMMD3-BMI1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for COMMD3-BMI1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for COMMD3-BMI1 Gene

This gene is overexpressed in Retina (19.8), Blymphocyte (15.6), CD8 Tcells (8.6), and Fetal ovary (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from MOPED for COMMD3-BMI1 Gene



Protein tissue co-expression partners for COMMD3-BMI1 Gene

genes like me logo Genes that share expression patterns with COMMD3-BMI1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for COMMD3-BMI1 Gene

Orthologs for COMMD3-BMI1 Gene

This gene was present in the common ancestor of animals.

Orthologs for COMMD3-BMI1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 100 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 98 (a)
OneToMany
cow
(Bos Taurus)
Mammalia BMI1 34 33
  • 95.91 (n)
OneToMany
dog
(Canis familiaris)
Mammalia BMI1 34 33
  • 95.09 (n)
OneToMany
mouse
(Mus musculus)
Mammalia Bmi1 34 16 33
  • 92.59 (n)
OneToMany
rat
(Rattus norvegicus)
Mammalia Bmi1 33
  • 89.61 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 82 (a)
OneToMany
chicken
(Gallus gallus)
Aves BMI1 34 33
  • 78.83 (n)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 88 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia bmi1 33
  • 77.98 (n)
zebrafish
(Danio rerio)
Actinopterygii bmi1a 34
  • 82 (a)
ManyToMany
bmi1b 34 33
  • 72.41 (n)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Psc 34
  • 8 (a)
ManyToMany
Su(z)2 34
  • 7 (a)
ManyToMany
Species where no ortholog for COMMD3-BMI1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COMMD3-BMI1 Gene

ENSEMBL:
Gene Tree for COMMD3-BMI1 (if available)
TreeFam:
Gene Tree for COMMD3-BMI1 (if available)

Paralogs for COMMD3-BMI1 Gene

Paralogs for COMMD3-BMI1 Gene

(9) SIMAP similar genes for COMMD3-BMI1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for COMMD3-BMI1 Gene

genes like me logo Genes that share paralogs with COMMD3-BMI1: view

Variants for COMMD3-BMI1 Gene

Sequence variations from dbSNP and Humsavar for COMMD3-BMI1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000104172 -- 22,331,976(+) ATGTT(A/C/T)GAAAT downstream-variant-500B
rs1000809035 -- 22,316,383(+) GTCAC(G/T)TGGTG utr-variant-5-prime
rs1000814650 -- 22,319,566(+) TGAAA(A/C/T)TGAAT intron-variant, upstream-variant-2KB
rs1001019137 -- 22,321,447(+) GAGGC(-/GGAGGA)GGAGG intron-variant, cds-indel
rs1001065063 -- 22,326,251(+) TTTTG(C/T)ATCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COMMD3-BMI1 Gene

Variant ID Type Subtype PubMed ID
dgv1002n54 CNV loss 21841781
dgv1003n54 CNV loss 21841781
dgv136n67 CNV gain 20364138
dgv137n67 CNV gain 20364138
esv27808 CNV gain 19812545
nsv1069031 CNV deletion 25765185
nsv1143626 CNV deletion 24896259
nsv550207 CNV loss 21841781
nsv825300 CNV gain 20364138
nsv951254 CNV duplication 24416366

Variation tolerance for COMMD3-BMI1 Gene

Residual Variation Intolerance Score: 10.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COMMD3-BMI1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
COMMD3-BMI1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COMMD3-BMI1 Gene

Disorders for COMMD3-BMI1 Gene

Relevant External Links for COMMD3-BMI1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COMMD3-BMI1

No disorders were found for COMMD3-BMI1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COMMD3-BMI1 Gene

Publications for COMMD3-BMI1 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  2. The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis. (PMID: 26687479) Oliviero G … Cagney G (Scientific reports 2015) 3 60
  3. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta GD … Pelletier L (Cell 2015) 3 60
  4. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 60

Products for COMMD3-BMI1 Gene

Sources for COMMD3-BMI1 Gene

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