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Aliases for COMMD3 Gene

Aliases for COMMD3 Gene

  • COMM Domain Containing 3 2 3
  • Protein Bup 3 4
  • C10orf8 3 4
  • BUP 3 4
  • Chromosome 10 Open Reading Frame 8 2
  • COMM Domain-Containing Protein 3 3
  • Protein PIL 4

External Ids for COMMD3 Gene

Previous Symbols for COMMD3 Gene

  • C10orf8

Summaries for COMMD3 Gene

GeneCards Summary for COMMD3 Gene

COMMD3 (COMM Domain Containing 3) is a Protein Coding gene.

UniProtKB/Swiss-Prot for COMMD3 Gene

  • May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits (PubMed:23637203).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COMMD3 Gene

Genomics for COMMD3 Gene

Genomic Location for COMMD3 Gene

Start:
22,315,974 bp from pter
End:
22,320,317 bp from pter
Size:
4,344 bases
Orientation:
Plus strand

Genomic View for COMMD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COMMD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COMMD3 Gene

Regulatory Elements for COMMD3 Gene

Proteins for COMMD3 Gene

  • Protein details for COMMD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBI1-COMD3_HUMAN
    Recommended name:
    COMM domain-containing protein 3
    Protein Accession:
    Q9UBI1
    Secondary Accessions:
    • D3DRU7
    • Q5T8Y9

    Protein attributes for COMMD3 Gene

    Size:
    195 amino acids
    Molecular mass:
    22151 Da
    Quaternary structure:
    • Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with NFKB1/p105. Interacts with CCDC22, CCDC93, SCNN1B, CUL3, CUL4A, CUL4B, CUL5.

neXtProt entry for COMMD3 Gene

Proteomics data for COMMD3 Gene at MOPED

Post-translational modifications for COMMD3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys52, Lys60, Lys108, and Lys137

Other Protein References for COMMD3 Gene

No data available for DME Specific Peptides for COMMD3 Gene

Domains for COMMD3 Gene

Protein Domains for COMMD3 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

COMD3_HUMAN
Domain:
  • Contains 1 COMM domain.:
    • Q9UBI1
genes like me logo Genes that share domains with COMMD3: view

No data available for Gene Families for COMMD3 Gene

Function for COMMD3 Gene

Molecular function for COMMD3 Gene

UniProtKB/Swiss-Prot Function: May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits (PubMed:23637203).

Gene Ontology (GO) - Molecular Function for COMMD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15799966
genes like me logo Genes that share ontologies with COMMD3: view

Phenotypes for COMMD3 Gene

GenomeRNAi human phenotypes for COMMD3:
genes like me logo Genes that share phenotypes with COMMD3: view

miRNA for COMMD3 Gene

miRTarBase miRNAs that target COMMD3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for COMMD3 Gene

Localization for COMMD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COMMD3 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COMMD3 Gene COMPARTMENTS Subcellular localization image for COMMD3 gene
Compartment Confidence
cytoskeleton 1
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for COMMD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with COMMD3: view

Pathways for COMMD3 Gene

SuperPathways for COMMD3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for COMMD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006814 sodium ion transport IEA --
genes like me logo Genes that share ontologies with COMMD3: view

No data available for Pathways by source for COMMD3 Gene

Transcripts for COMMD3 Gene

Unigene Clusters for COMMD3 Gene

COMM domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COMMD3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d · 9e
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5: - - - -
SP6: - - - - -
SP7: - - - -
SP8: - - -
SP9: - - -
SP10: - -
SP11: -

Relevant External Links for COMMD3 Gene

GeneLoc Exon Structure for
COMMD3
ECgene alternative splicing isoforms for
COMMD3

Expression for COMMD3 Gene

mRNA expression in normal human tissues for COMMD3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COMMD3 Gene

SOURCE GeneReport for Unigene cluster for COMMD3 Gene Hs.534398

mRNA Expression by UniProt/SwissProt for COMMD3 Gene

Q9UBI1-COMD3_HUMAN
Tissue specificity: Widely expressed with highest expression in thymus.
genes like me logo Genes that share expressions with COMMD3: view

Orthologs for COMMD3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for COMMD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COMMD3 36
  • 99.32 (n)
  • 98.46 (a)
COMMD3 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia COMMD3 36
  • 94.19 (n)
  • 91.79 (a)
COMMD3 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COMMD3 36
  • 94.7 (n)
  • 94.36 (a)
COMMD3 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Commd3 36
  • 91.97 (n)
  • 89.23 (a)
Commd3 16
Commd3 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia COMMD3 37
  • 36 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COMMD3 37
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Commd3 36
  • 91.62 (n)
  • 90.77 (a)
chicken
(Gallus gallus)
Aves COMMD3 36
  • 64.17 (n)
  • 68.03 (a)
COMMD3 37
  • 36 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COMMD3 37
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia xbmi-1 36
tropical clawed frog
(Silurana tropicalis)
Amphibia commd3 36
  • 69.23 (n)
  • 63.59 (a)
zebrafish
(Danio rerio)
Actinopterygii bmi1 36
commd3 36
  • 59.51 (n)
  • 53.4 (a)
commd3 37
  • 52 (a)
OneToOne
Species with no ortholog for COMMD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COMMD3 Gene

ENSEMBL:
Gene Tree for COMMD3 (if available)
TreeFam:
Gene Tree for COMMD3 (if available)

Paralogs for COMMD3 Gene

Selected SIMAP similar genes for COMMD3 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with COMMD3: view

No data available for Paralogs for COMMD3 Gene

Variants for COMMD3 Gene

Sequence variations from dbSNP and Humsavar for COMMD3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
VAR_061121 -

Structural Variations from Database of Genomic Variants (DGV) for COMMD3 Gene

Variant ID Type Subtype PubMed ID
dgv136n67 CNV Gain 20364138
dgv137n67 CNV Gain 20364138
dgv624n71 CNV Loss 21882294
dgv625n71 CNV Loss 21882294
nsv894959 CNV Loss 21882294
esv27808 CNV Gain 19812545

Relevant External Links for COMMD3 Gene

HapMap Linkage Disequilibrium report
COMMD3

Disorders for COMMD3 Gene

No disorders were found for COMMD3 Gene.

No data available for UniProtKB/Swiss-Prot for COMMD3 Gene

Publications for COMMD3 Gene

  1. COMMD proteins, a novel family of structural and functional homologs of MURR1. (PMID: 15799966) Burstein E. … Duckett C.S. (J. Biol. Chem. 2005) 2 3 4
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3

Products for COMMD3 Gene

Sources for COMMD3 Gene

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