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Aliases for COMMD3 Gene

Aliases for COMMD3 Gene

  • COMM Domain Containing 3 2 3
  • Protein Bup 3 4
  • C10orf8 3 4
  • BUP 3 4
  • Chromosome 10 Open Reading Frame 8 2
  • Protein PIL 4

External Ids for COMMD3 Gene

Previous HGNC Symbols for COMMD3 Gene

  • C10orf8

Previous GeneCards Identifiers for COMMD3 Gene

  • GC10P022610
  • GC10P022645
  • GC10P022604
  • GC10P022266

Summaries for COMMD3 Gene

GeneCards Summary for COMMD3 Gene

COMMD3 (COMM Domain Containing 3) is a Protein Coding gene.

UniProtKB/Swiss-Prot for COMMD3 Gene

  • May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits (PubMed:23637203).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COMMD3 Gene

Genomics for COMMD3 Gene

Regulatory Elements for COMMD3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for COMMD3 Gene

Chromosome:
10
Start:
22,315,974 bp from pter
End:
22,320,317 bp from pter
Size:
4,344 bases
Orientation:
Plus strand

Genomic View for COMMD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for COMMD3 Gene

Proteins for COMMD3 Gene

  • Protein details for COMMD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBI1-COMD3_HUMAN
    Recommended name:
    COMM domain-containing protein 3
    Protein Accession:
    Q9UBI1
    Secondary Accessions:
    • D3DRU7
    • Q5T8Y9

    Protein attributes for COMMD3 Gene

    Size:
    195 amino acids
    Molecular mass:
    22151 Da
    Quaternary structure:
    • Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with NFKB1/p105. Interacts with CCDC22, CCDC93, SCNN1B, CUL3, CUL4A, CUL4B, CUL5.

neXtProt entry for COMMD3 Gene

Proteomics data for COMMD3 Gene at MOPED

Post-translational modifications for COMMD3 Gene

  • Ubiquitination at Lys 9, Lys 52, Lys 60, Lys 108, and Lys 137
  • Modification sites at PhosphoSitePlus

Other Protein References for COMMD3 Gene

No data available for DME Specific Peptides for COMMD3 Gene

Domains & Families for COMMD3 Gene

Gene Families for COMMD3 Gene

Protein Domains for COMMD3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for COMMD3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UBI1

UniProtKB/Swiss-Prot:

COMD3_HUMAN :
  • Contains 1 COMM domain.
Domain:
  • Contains 1 COMM domain.
genes like me logo Genes that share domains with COMMD3: view

Function for COMMD3 Gene

Molecular function for COMMD3 Gene

UniProtKB/Swiss-Prot Function:
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits (PubMed:23637203).

Gene Ontology (GO) - Molecular Function for COMMD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15799966
genes like me logo Genes that share ontologies with COMMD3: view
genes like me logo Genes that share phenotypes with COMMD3: view

Animal Model Products

miRNA for COMMD3 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COMMD3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for COMMD3 Gene

Localization for COMMD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COMMD3 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COMMD3 Gene COMPARTMENTS Subcellular localization image for COMMD3 gene
Compartment Confidence
nucleus 3
chloroplast 1

Gene Ontology (GO) - Cellular Components for COMMD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with COMMD3: view

Pathways & Interactions for COMMD3 Gene

SuperPathways for COMMD3 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for COMMD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006814 sodium ion transport IEA --
genes like me logo Genes that share ontologies with COMMD3: view

No data available for Pathways by source and SIGNOR curated interactions for COMMD3 Gene

Drugs & Compounds for COMMD3 Gene

No Compound Related Data Available

Transcripts for COMMD3 Gene

Unigene Clusters for COMMD3 Gene

COMM domain containing 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COMMD3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COMMD3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d · 9e
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5: - - - -
SP6: - - - - -
SP7: - - - -
SP8: - - -
SP9: - - -
SP10: - -
SP11: -

Relevant External Links for COMMD3 Gene

GeneLoc Exon Structure for
COMMD3
ECgene alternative splicing isoforms for
COMMD3

Expression for COMMD3 Gene

mRNA expression in normal human tissues for COMMD3 Gene

Protein differential expression in normal tissues from HIPED for COMMD3 Gene

This gene is overexpressed in Bone (12.0) and Peripheral blood mononuclear cells (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for COMMD3 Gene



SOURCE GeneReport for Unigene cluster for COMMD3 Gene Hs.534398

mRNA Expression by UniProt/SwissProt for COMMD3 Gene

Q9UBI1-COMD3_HUMAN
Tissue specificity: Widely expressed with highest expression in thymus.
genes like me logo Genes that share expression patterns with COMMD3: view

Protein tissue co-expression partners for COMMD3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for COMMD3 Gene

Orthologs for COMMD3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for COMMD3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia COMMD3 35
  • 94.19 (n)
  • 91.79 (a)
COMMD3 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COMMD3 35
  • 94.7 (n)
  • 94.36 (a)
COMMD3 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Commd3 35
  • 91.97 (n)
  • 89.23 (a)
Commd3 16
Commd3 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia COMMD3 35
  • 99.32 (n)
  • 98.46 (a)
COMMD3 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Commd3 35
  • 91.62 (n)
  • 90.77 (a)
oppossum
(Monodelphis domestica)
Mammalia COMMD3 36
  • 36 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COMMD3 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves COMMD3 35
  • 64.17 (n)
  • 68.03 (a)
COMMD3 36
  • 36 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COMMD3 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia commd3 35
  • 69.23 (n)
  • 63.59 (a)
African clawed frog
(Xenopus laevis)
Amphibia xbmi-1 35
zebrafish
(Danio rerio)
Actinopterygii bmi1 35
commd3 35
  • 59.51 (n)
  • 53.4 (a)
commd3 36
  • 52 (a)
OneToOne
Species with no ortholog for COMMD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COMMD3 Gene

ENSEMBL:
Gene Tree for COMMD3 (if available)
TreeFam:
Gene Tree for COMMD3 (if available)

Paralogs for COMMD3 Gene

(7) SIMAP similar genes for COMMD3 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with COMMD3: view

No data available for Paralogs for COMMD3 Gene

Variants for COMMD3 Gene

Sequence variations from dbSNP and Humsavar for COMMD3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
VAR_061121 -

Structural Variations from Database of Genomic Variants (DGV) for COMMD3 Gene

Variant ID Type Subtype PubMed ID
dgv136n67 CNV Gain 20364138
dgv137n67 CNV Gain 20364138
dgv624n71 CNV Loss 21882294
dgv625n71 CNV Loss 21882294
nsv894959 CNV Loss 21882294
esv27808 CNV Gain 19812545

Variation tolerance for COMMD3 Gene

Residual Variation Intolerance Score: 35.86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.80; 79.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COMMD3 Gene

HapMap Linkage Disequilibrium report
COMMD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COMMD3 Gene

Disorders for COMMD3 Gene

Relevant External Links for COMMD3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COMMD3
genes like me logo Genes that share disorders with COMMD3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COMMD3 Gene

Publications for COMMD3 Gene

  1. COMMD proteins, a novel family of structural and functional homologs of MURR1. (PMID: 15799966) Burstein E. … Duckett C.S. (J. Biol. Chem. 2005) 2 67
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 67
  3. COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A. (PMID: 25355947) Phillips-Krawczak C.A. … Burstein E. (Mol. Biol. Cell 2015) 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 67

Products for COMMD3 Gene

Sources for COMMD3 Gene

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