COMMD3 Gene
protein-coding GIFtS: 46
GCID: GC10P022604
|
|
COMM domain containing 3(Previous name: chromosome 10 open reading frame 8 )
(Previous symbol: C10orf8)
| |
Aliases
for COMMD3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| COMM Domain Containing 31 2 | | Chromosome 10 Open Reading Frame 81 | | BUP1 2 3 | | COMM Domain-Containing Protein 32 | | C10orf81 2 3 | | Protein PIL3 | | Protein Bup2 3 | | |
Export aliases for COMMD3 gene to outside databasesPrevious GC identifers: GC10P022610 GC10P022645 GC10P022266 |
Summaries
for COMMD3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: COMD3_HUMAN, Q9UBI1Function: May down-regulate activation of NF-kappa-B
|
Genomic Views
for COMMD3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_008705.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the COMMD3 gene promoter:
POU2F1 FOXC1 HNF-1 POU2F1a Zic1 HNF-1A YY1
Other transcription factors
Search SABiosciences Chromatin IP Primers for COMMD3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COMMD3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10p12.2 Ensembl cytogenetic band: 10p12.2 HGNC cytogenetic band: 10p12.2COMMD3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P022604: view genomic region
(about GC identifiers)
Start:
|
22,604,903 bp from pter |
End:
|
22,609,237 bp from pter |
Size:
|
4,335 bases |
Orientation:
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plus strand |
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Proteins
for COMMD3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: COMD3_HUMAN, Q9UBI1 (See
protein sequence)Recommended Name: COMM domain-containing protein 3 Size: 195 amino acids; 22151 Da
Subunit: Interacts (via COMM domain) with COMMD1 (via COMM domain)
Secondary accessions: D3DRU7 Q5T8Y9Explore the universe of human proteins at neXtProt for COMMD3: NX_Q9UBI1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UBI1
COMMD3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_036203.1
ENSEMBL proteins: ENSP00000366032 ENSP00000394580 ENSP00000408982 ENSP00000391237
Human Recombinant Protein Products:
COMMD3 Antibody Products:
Assay Products for COMMD3: |
Protein
Domains /
Families
for COMMD3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
COMMD3 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UBI1ProtoNet protein and cluster: Q9UBI1 1 Blocks protein family: IPB009886 HCaRG
UniProtKB/Swiss-Prot: COMD3_HUMAN, Q9UBI1Similarity: Contains 1 COMM domain |
Function
for COMMD3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: COMD3_HUMAN, Q9UBI1Function: May down-regulate activation of NF-kappa-B
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for COMMD3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COMMD3 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
COMMD3 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for COMMD3:
|
Pathways & Interactions
for COMMD3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for COMMD3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 24)
5/25 Interacting proteins for COMMD3 (Q9UBI11, 2, 3 ENSP000003660324) via UniProtKB, MINT, STRING, and/or I2D (see all 25)About this table
|
Drugs & Compounds
for COMMD3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for COMMD3
Search CenterWatch for drugs/clinical trials and news about COMMD3 / COMD3
|
Transcripts
for COMMD3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for COMMD3 gene: NM_012071.3 Unigene Cluster for COMMD3: COMM domain containing 3 Hs.534398 [show with all ESTs]Unigene Representative Sequence: BX64727517 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000376836(uc001irf.3) ENST00000475460 ENST00000463409 ENST00000468179
ENST00000489125 ENST00000470045 ENST00000456711 ENST00000444869 ENST00000472610
ENST00000496071 ENST00000448361 ENST00000479958 ENST00000468469 ENST00000472673
ENST00000483684 ENST00000471350 ENST00000463688
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: COMMD3 (NM_012071) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COMMD3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COMMD3 |
Additional cDNA sequence: AF078848.1 AF201948.1 AK128789.1 AK295109.1 AY542159.1 BC022898.2 BX647275.1 18 DOTS entries: DT.100758566 DT.452795 DT.100705048 DT.449571 DT.100036809 DT.40111690 DT.100824089 DT.91753532 DT.91753504 DT.121280780 DT.100824088 DT.91753503 DT.95302412 DT.100824084 DT.121280752 DT.121280842 DT.91753533 DT.95302452 24/520 AceView cDNA sequences (see all 520): BC022898 BM819196 BU678199 BM927315 W32496 BM313765 BF445641 BX362488 AI360621 BM978631 AA724394 CF128831 BU627952 BQ271761 BC011652 N67528 AA305122 C00368 NM_005180 BM785335 AI362205 BX441736 CR610659 BM714237
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for COMMD3 (see all 11) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d | · | 9e |
|---|
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| SP1: | | | | | | | - | | - | | | | - | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | | | - | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | | | - | | | | - | | | | - | | - | | - | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | - | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for COMMD3
|
Expression
for COMMD3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| COMMD3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAACAATTAC
About this image
See COMMD3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for COMMD3
SOURCE GeneReport for Unigene cluster: Hs.534398
UniProtKB/Swiss-Prot: COMD3_HUMAN, Q9UBI1Tissue specificity: Widely expressed with highest expression in thymus
SABiosciences Expression via Pathway-Focused PCR Array including COMMD3:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COMMD3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat COMMD3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COMMD3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COMMD3 |
Orthologs
for COMMD3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for COMMD3 gene from 6/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Commd31 , 5 |
COMM domain containing 31, 5 |
91.97(n)1
89.23(a)1 |
|
2 (12.90 cM)5
122381 NM_147778.31 NP_680087.11
186724235 |
chicken
(Gallus gallus) |
Aves |
COMMD36 |
Uncharacterized protein |
63(a) |
1 ↔ 1 |
2(17654718-17656192) |
lizard
(Anolis carolinensis) |
Reptilia |
COMMD36 |
-- |
77(a) |
1 ↔ 1 |
6(16354961-16357195) |
African clawed frog
(Xenopus laevis) |
Amphibia |
xbmi-12 |
xbmi-1 protein |
77.82(n) |
|
U39959.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
bmi12 |
B lymphoma Mo-MLV insertion region 1 homolog (mouse) |
79.75(n) |
|
321505 AB074153.1 |
honey bee
(Apis mellifera) |
Insecta |
-- |
-- |
28(a) |
1 ↔ 1 |
GroupUn.447(4122-4852) |
ENSEMBL Gene Tree for COMMD3 (if available)
TreeFam Gene Tree for COMMD3 (if available) |
Paralogs
for COMMD3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for COMMD3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for COMMD3 (22604903 - 22609237 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for COMMD3
1 CNV: 70935 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COMMD3 |
|
Disorders
/ Diseases
for COMMD3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for COMMD3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for COMMD3 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with COMMD3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- COMMD proteins, a novel family of structural and functional homologs of MURR1. (PubMed id 15799966)1, 2, 3 Burstein E....Duckett C.S. (2005)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
|
External Searches for COMMD3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing COMMD3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing COMMD3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing COMMD3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for COMMD3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for COMMD3 gene:
Search GeneIP for patents involving COMMD3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for COMMD3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for COMMD3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COMMD3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COMMD3 | | | OriGene Protein Over-expression Lysate for COMMD3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for COMMD3 | | OriGene 3'-UTR Clone for COMMD3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for COMMD3 | | OriGene Custom Protein Services for COMMD3 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat COMMD3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COMMD3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COMMD3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COMMD3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COMMD3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COMMD3 |
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 |  |  |  | |
| | | | Search Tocris compounds for COMMD3 |
| |  |  |  |  | | | | |
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 | | | COMMD3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for COMMD3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COMMD3 |
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