COMMD2 Gene
protein-coding GIFtS: 44
GCID: GC03M149448
|
|
COMM domain containing 2
| |
Aliases
for COMMD2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| COMM Domain Containing 21 2 | | HSPC0421 | | COMM Domain-Containing Protein 22 |
Export aliases for COMMD2 gene to outside databasesPrevious GC identifers: GC03M150780 GC03M150941 GC03M146829 |
Summaries
for COMMD2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: COMD2_HUMAN, Q86X83Function: May down-regulate activation of NF-kappa-B
|
Genomic Views
for COMMD2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the COMMD2 gene promoter:
SRF SRF (504 AA) Lmo2 Pax-2 Pax-2a Tal-1beta E47 SRY FAC1 Pax-2b
Other transcription factors
Search SABiosciences Chromatin IP Primers for COMMD2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COMMD2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q25.1 Ensembl cytogenetic band: 3q25.1 HGNC cytogenetic band: 3q25.1COMMD2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M149448: view genomic region
(about GC identifiers)
Start:
|
149,456,257 bp from pter |
End:
|
149,470,286 bp from pter |
Size:
|
14,030 bases |
Orientation:
|
minus strand |
|
Proteins
for COMMD2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: COMD2_HUMAN, Q86X83 (See
protein sequence)Recommended Name: COMM domain-containing protein 2 Size: 199 amino acids; 22745 Da
Subunit: Interacts (via COMM domain) with COMMD1 (via COMM domain)
Sequence caution: Sequence=AAD39913.1; Type=Frameshift; Positions=111, 160, 174, 188;
Secondary accessions: Q9H3L5 Q9Y5V1Explore the universe of human proteins at neXtProt for COMMD2: NX_Q86X83
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86X83
COMMD2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057178.2
ENSEMBL proteins: ENSP00000419475 ENSP00000417962 ENSP00000418865
Human Recombinant Protein Products:
COMMD2 Antibody Products:
Assay Products for COMMD2: |
Protein
Domains /
Families
for COMMD2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
COMMD2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86X83ProtoNet protein and cluster: Q86X83 1 Blocks protein family: IPB009886 HCaRG
UniProtKB/Swiss-Prot: COMD2_HUMAN, Q86X83Similarity: Contains 1 COMM domain |
Function
for COMMD2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: COMD2_HUMAN, Q86X83Function: May down-regulate activation of NF-kappa-B
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: COMMD2 (NM_016094) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COMMD2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COMMD2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COMMD2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
COMMD2 for ontologies About GeneDecksing
|
Pathways & Interactions
for COMMD2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for COMMD2
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5 Interacting proteins for COMMD2 (Q86X833 ENSP000004194754) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for COMMD2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for COMMD2
Search CenterWatch for drugs/clinical trials and news about COMMD2 / COMD2
|
Transcripts
for COMMD2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for COMMD2 gene: NM_016094.3 Unigene Cluster for COMMD2: COMM domain containing 2 Hs.432729 [show with all ESTs]Unigene Representative Sequence: NM_0160947 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000473414(uc003exj.2) ENST00000491617 ENST00000463077 ENST00000483708
ENST00000469896 ENST00000483146 ENST00000490008
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: COMMD2 (NM_016094) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COMMD2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COMMD2 |
Additional cDNA sequence: AF059618.1 AF125096.1 AK055223.1 AY542158.1 BC001228.1 BC022206.1 BC046131.1 BC093077.1 8 DOTS entries: DT.75175954 DT.100780945 DT.91673219 DT.100780944 DT.40278668 DT.120844661 DT.95368982 DT.413048 24/164 AceView cDNA sequences (see all 164): BU633168 BG943263 AA425307 AA983793 CB069707 AA226773 AI086830 NM_016094 AA720631 AI184321 AA399203 AI079311 AA342182 CR613367 BX951966 BM709829 AW629139 AK055223 AI436195 AW025074 AA227025 BE673685 BM981499 BM457604
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for COMMD2 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c |
|---|
|
| SP1: | | | | | | | | | | | - | | | | - | | | | - | | - | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | - | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | | | - | | - | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | - | | | | - | | - | | | | | | | |
ECgene alternative splicing isoforms for COMMD2
|
Expression
for COMMD2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| COMMD2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATATAGAAT
About this image
See COMMD2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for COMMD2
SOURCE GeneReport for Unigene cluster: Hs.432729
UniProtKB/Swiss-Prot: COMD2_HUMAN, Q86X83Tissue specificity: Ubiquitous
SABiosciences Custom PCR Arrays for COMMD2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COMMD2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat COMMD2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COMMD2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COMMD2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COMMD2 |
Orthologs
for COMMD2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for COMMD2 gene from 6/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Commd21 , 5 |
COMM domain containing 21, 5 |
87.27(n)1
93.97(a)1 |
|
3 (27.94 cM)5
522451 NM_175095.41 NP_780304.21
576429045 |
chicken
(Gallus gallus) |
Aves |
COMMD26 |
Uncharacterized protein |
79(a) |
1 ↔ 1 |
9(25367523-25370083) |
lizard
(Anolis carolinensis) |
Reptilia |
COMMD26 |
-- |
85(a) |
1 ↔ 1 |
3(18819281-18828358) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.46592 |
Xenopus laevis transcribed sequence with moderate similarity to protein refNP_057178.1 (H.sapiens) HSPC042 protein [Homo sapiens] less |
73.23(n) |
|
BX846095.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufb12e012 |
Transcribed sequence with moderate similarity to protein refNP_057178.1 (H.sapiens) HSPC042 protein [Homo sapiens] less |
74.05(n) |
|
CK354488.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG71681 |
CG7168 |
46.5(n)
35.38(a) |
|
42184 NM_142438.3 NP_650695.1 |
ENSEMBL Gene Tree for COMMD2 (if available)
TreeFam Gene Tree for COMMD2 (if available) |
Paralogs
for COMMD2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for COMMD2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for COMMD2 (149456257 - 149470286 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for COMMD2
1 CNV: 48020 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COMMD2 |
|
Disorders
/ Diseases
for COMMD2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for COMMD2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for COMMD2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with COMMD2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- COMMD proteins, a novel family of structural and functional homologs of MURR1. (PubMed id 15799966)1, 2, 3 Burstein E....Duckett C.S. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
|
External Searches for COMMD2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing COMMD2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing COMMD2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing COMMD2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for COMMD2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for COMMD2 gene:
Search GeneIP for patents involving COMMD2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for COMMD2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for COMMD2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COMMD2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COMMD2 | | | OriGene Protein Over-expression Lysate for COMMD2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for COMMD2 | | OriGene 3'-UTR Clone for COMMD2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for COMMD2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for COMMD2 | | OriGene Custom Protein Services for COMMD2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat COMMD2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COMMD2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COMMD2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COMMD2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COMMD2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COMMD2 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for COMMD2 |
| |  |  |  |  | | | | |
 |
 |
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 | | | COMMD2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COMMD2 |
|  |  |  | | | | ThermoFisher Antibody for COMMD2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COMMD2 |
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