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Aliases for COMMD2 Gene

Aliases for COMMD2 Gene

  • COMM Domain Containing 2 2 3
  • COMM Domain-Containing Protein 2 3
  • HSPC042 3

External Ids for COMMD2 Gene

Previous GeneCards Identifiers for COMMD2 Gene

  • GC03M150780
  • GC03M150941
  • GC03M149448
  • GC03M146829

Summaries for COMMD2 Gene

GeneCards Summary for COMMD2 Gene

COMMD2 (COMM Domain Containing 2) is a Protein Coding gene.

UniProtKB/Swiss-Prot for COMMD2 Gene

  • May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COMMD2 Gene

Genomics for COMMD2 Gene

Regulatory Elements for COMMD2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for COMMD2 Gene

149,738,470 bp from pter
149,752,500 bp from pter
14,031 bases
Minus strand

Genomic View for COMMD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COMMD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COMMD2 Gene

Proteins for COMMD2 Gene

  • Protein details for COMMD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    COMM domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • Q561V4
    • Q9H3L5
    • Q9Y5V1

    Protein attributes for COMMD2 Gene

    199 amino acids
    Molecular mass:
    22745 Da
    Quaternary structure:
    • Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with RELA, RELB, NFKB1/p105, NFKB2/p100. Interacts with CCDC22, CCDC93, SCNN1B, CUL3, CUL4B, CUL5, CUL7.
    • Sequence=AAD39913.1; Type=Frameshift; Positions=111, 160, 174, 188; Evidence={ECO:0000305};

    Alternative splice isoforms for COMMD2 Gene


neXtProt entry for COMMD2 Gene

Proteomics data for COMMD2 Gene at MOPED

Post-translational modifications for COMMD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for COMMD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for COMMD2

No data available for DME Specific Peptides for COMMD2 Gene

Domains for COMMD2 Gene

Gene Families for COMMD2 Gene

Protein Domains for COMMD2 Gene


Suggested Antigen Peptide Sequences for COMMD2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 COMM domain.
  • Contains 1 COMM domain.
genes like me logo Genes that share domains with COMMD2: view

Function for COMMD2 Gene

Molecular function for COMMD2 Gene

UniProtKB/Swiss-Prot Function:
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966).

Gene Ontology (GO) - Molecular Function for COMMD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15799966
genes like me logo Genes that share ontologies with COMMD2: view

Animal Model Products

miRNA for COMMD2 Gene

miRTarBase miRNAs that target COMMD2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COMMD2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for COMMD2 Gene

Localization for COMMD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COMMD2 Gene


Subcellular locations from

Jensen Localization Image for COMMD2 Gene COMPARTMENTS Subcellular localization image for COMMD2 gene
Compartment Confidence
cytoskeleton 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for COMMD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with COMMD2: view

Pathways for COMMD2 Gene

SuperPathways for COMMD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for COMMD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with COMMD2: view

No data available for Pathways by source for COMMD2 Gene

Transcripts for COMMD2 Gene

Unigene Clusters for COMMD2 Gene

COMM domain containing 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COMMD2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COMMD2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - -
SP5: - - - -

Relevant External Links for COMMD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COMMD2 Gene

mRNA expression in normal human tissues for COMMD2 Gene

Protein differential expression in normal tissues for COMMD2 Gene

This gene is overexpressed in Monocytes (24.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COMMD2 Gene

SOURCE GeneReport for Unigene cluster for COMMD2 Gene Hs.432729

mRNA Expression by UniProt/SwissProt for COMMD2 Gene

Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with COMMD2: view

Expression partners for COMMD2 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for COMMD2 Gene

Orthologs for COMMD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for COMMD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia COMMD2 35
  • 90.28 (n)
  • 94.47 (a)
  • 94 (a)
(Canis familiaris)
Mammalia COMMD2 35
  • 90.62 (n)
  • 95.48 (a)
  • 95 (a)
(Mus musculus)
Mammalia Commd2 35
  • 87.27 (n)
  • 93.97 (a)
Commd2 16
Commd2 36
  • 94 (a)
(Pan troglodytes)
Mammalia COMMD2 35
  • 99.16 (n)
  • 98.99 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Commd2 35
  • 86.77 (n)
  • 93.47 (a)
(Monodelphis domestica)
Mammalia COMMD2 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia COMMD2 36
  • 88 (a)
(Gallus gallus)
Aves COMMD2 35
  • 75.38 (n)
  • 77.89 (a)
  • 78 (a)
(Anolis carolinensis)
Reptilia COMMD2 36
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia commd2 35
  • 70.02 (n)
  • 78.39 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4659 35
(Danio rerio)
Actinopterygii commd2 35
  • 68.01 (n)
  • 76.88 (a)
wufb12e01 35
commd2 36
  • 77 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7168 36
  • 28 (a)
Species with no ortholog for COMMD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COMMD2 Gene

Gene Tree for COMMD2 (if available)
Gene Tree for COMMD2 (if available)

Paralogs for COMMD2 Gene

No data available for Paralogs for COMMD2 Gene

Variants for COMMD2 Gene

Sequence variations from dbSNP and Humsavar for COMMD2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1403027 -- 149,752,467(-) TGCCG(C/G)GTGAA utr-variant-5-prime, nc-transcript-variant
rs1546732 - 149,741,590(-) GTTCA(A/T)CAACT reference, missense, nc-transcript-variant
rs1972147 -- 149,742,876(-) cagtt(C/T)tcctg intron-variant
rs4577408 -- 149,738,028(+) ACCTA(G/T)AAAAG downstream-variant-500B
rs4632484 -- 149,743,333(+) ttgaa(A/G)tctag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COMMD2 Gene

Variant ID Type Subtype PubMed ID
nsv877642 CNV Gain 21882294
esv34142 CNV Loss 18971310
nsv829754 CNV Gain 17160897

Relevant External Links for COMMD2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COMMD2 Gene

Disorders for COMMD2 Gene

No disorders were found for COMMD2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for COMMD2 Gene

Publications for COMMD2 Gene

  1. COMMD proteins, a novel family of structural and functional homologs of MURR1. (PMID: 15799966) Burstein E. … Duckett C.S. (J. Biol. Chem. 2005) 2 3 4
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for COMMD2 Gene

Sources for COMMD2 Gene

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