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Aliases for COMMD2 Gene

Aliases for COMMD2 Gene

  • COMM Domain Containing 2 2 3 5
  • COMM Domain-Containing Protein 2 3
  • HSPC042 3

External Ids for COMMD2 Gene

Previous GeneCards Identifiers for COMMD2 Gene

  • GC03M150780
  • GC03M150941
  • GC03M149448
  • GC03M146829

Summaries for COMMD2 Gene

GeneCards Summary for COMMD2 Gene

COMMD2 (COMM Domain Containing 2) is a Protein Coding gene.

UniProtKB/Swiss-Prot for COMMD2 Gene

  • May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966).

Additional gene information for COMMD2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COMMD2 Gene

Genomics for COMMD2 Gene

Regulatory Elements for COMMD2 Gene

Enhancers for COMMD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H149506 1.6 FANTOM5 Ensembl ENCODE dbSUPER 20.5 +245.1 245091 2 ESRRA FOXA2 JUN MAX EBF1 RARA ETS1 CTBP1 GATA3 RCOR1 COMMD2 WWTR1 TM4SF4 WWTR1-AS1 RNF13 LOC100421817 RNU6-1098P
GH03H150406 1.4 ENCODE dbSUPER 21.7 -658.8 -658819 9 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 COMMD2 RPL32P9 LOC730021 ENSG00000241929 WWTR1 WWTR1-IT1 EIF2A NPM1P29 GC03M150408 GC03P150463
GH03H149811 1.5 FANTOM5 ENCODE 16.9 -62.4 -62352 5 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143 FOS PFN2 RNF13 COMMD2 TSC22D2 PPIAP73 RNU6-720P
GH03H150344 1.4 Ensembl ENCODE dbSUPER 15.7 -595.9 -595858 8 TBP PKNOX1 NFIB SREBF2 SIN3A BMI1 RAD21 BRCA1 ZBTB40 RFX5 COMMD2 TSC22D2 EIF2A P2RY14 LINC01214
GH03H150375 1.5 Ensembl ENCODE dbSUPER 14.2 -623.8 -623836 1 ATF1 YY1 ZNF766 ELK1 ATF7 ZNF592 MEF2D MAFF ATF4 SMARCA4 TSC22D2 COMMD2 EIF2A LINC01214
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around COMMD2 on UCSC Golden Path with GeneCards custom track

Promoters for COMMD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000160042 110 1601 PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for COMMD2 Gene

Chromosome:
3
Start:
149,738,470 bp from pter
End:
149,752,510 bp from pter
Size:
14,041 bases
Orientation:
Minus strand

Genomic View for COMMD2 Gene

Genes around COMMD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COMMD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COMMD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COMMD2 Gene

Proteins for COMMD2 Gene

  • Protein details for COMMD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86X83-COMD2_HUMAN
    Recommended name:
    COMM domain-containing protein 2
    Protein Accession:
    Q86X83
    Secondary Accessions:
    • Q561V4
    • Q9H3L5
    • Q9Y5V1

    Protein attributes for COMMD2 Gene

    Size:
    199 amino acids
    Molecular mass:
    22745 Da
    Quaternary structure:
    • Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with RELA, RELB, NFKB1/p105, NFKB2/p100. Interacts with CCDC22, CCDC93, SCNN1B, CUL3, CUL4B, CUL5, CUL7.
    SequenceCaution:
    • Sequence=AAD39913.1; Type=Frameshift; Positions=111, 160, 174, 188; Evidence={ECO:0000305};

    Alternative splice isoforms for COMMD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COMMD2 Gene

Post-translational modifications for COMMD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for COMMD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for COMMD2 Gene

Domains & Families for COMMD2 Gene

Gene Families for COMMD2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for COMMD2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for COMMD2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with COMMD2: view

No data available for UniProtKB/Swiss-Prot for COMMD2 Gene

Function for COMMD2 Gene

Molecular function for COMMD2 Gene

UniProtKB/Swiss-Prot Function:
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966).

Phenotypes From GWAS Catalog for COMMD2 Gene

Gene Ontology (GO) - Molecular Function for COMMD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15799966
genes like me logo Genes that share ontologies with COMMD2: view
genes like me logo Genes that share phenotypes with COMMD2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for COMMD2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COMMD2 Gene

Localization for COMMD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COMMD2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for COMMD2 gene
Compartment Confidence
nucleus 3
cytoskeleton 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for COMMD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with COMMD2: view

Pathways & Interactions for COMMD2 Gene

SuperPathways for COMMD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for COMMD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with COMMD2: view

No data available for Pathways by source and SIGNOR curated interactions for COMMD2 Gene

Drugs & Compounds for COMMD2 Gene

No Compound Related Data Available

Transcripts for COMMD2 Gene

Unigene Clusters for COMMD2 Gene

COMM domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for COMMD2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for COMMD2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - -
SP5: - - - -
SP6:

Relevant External Links for COMMD2 Gene

GeneLoc Exon Structure for
COMMD2
ECgene alternative splicing isoforms for
COMMD2

Expression for COMMD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for COMMD2 Gene

Protein differential expression in normal tissues from HIPED for COMMD2 Gene

This gene is overexpressed in Monocytes (24.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for COMMD2 Gene



Protein tissue co-expression partners for COMMD2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of COMMD2 Gene:

COMMD2

SOURCE GeneReport for Unigene cluster for COMMD2 Gene:

Hs.432729

mRNA Expression by UniProt/SwissProt for COMMD2 Gene:

Q86X83-COMD2_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for COMMD2 Gene

  • Nervous system(4.6)
  • Liver(4.3)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with COMMD2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for COMMD2 Gene

Orthologs for COMMD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for COMMD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COMMD2 33 34
  • 99.16 (n)
dog
(Canis familiaris)
Mammalia COMMD2 33 34
  • 90.62 (n)
cow
(Bos Taurus)
Mammalia COMMD2 33 34
  • 90.28 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia COMMD2 34
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Commd2 33 16 34
  • 87.27 (n)
oppossum
(Monodelphis domestica)
Mammalia COMMD2 34
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Commd2 33
  • 86.77 (n)
chicken
(Gallus gallus)
Aves COMMD2 33 34
  • 75.38 (n)
lizard
(Anolis carolinensis)
Reptilia COMMD2 34
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia commd2 33
  • 70.02 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4659 33
zebrafish
(Danio rerio)
Actinopterygii commd2 33 34
  • 68.01 (n)
wufb12e01 33
fruit fly
(Drosophila melanogaster)
Insecta CG7168 34
  • 28 (a)
OneToOne
Species where no ortholog for COMMD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COMMD2 Gene

ENSEMBL:
Gene Tree for COMMD2 (if available)
TreeFam:
Gene Tree for COMMD2 (if available)

Paralogs for COMMD2 Gene

No data available for Paralogs for COMMD2 Gene

Variants for COMMD2 Gene

Sequence variations from dbSNP and Humsavar for COMMD2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000010538 -- 149,752,851(+) TTTCC(A/G)TTAGA upstream-variant-2KB
rs1000660101 -- 149,754,237(+) CTTGT(C/G)TGTAA upstream-variant-2KB
rs1001009365 -- 149,741,153(+) CCACC(G/T)CCCAG nc-transcript-variant, utr-variant-3-prime
rs1001162663 -- 149,748,283(+) GGTAC(A/C)TGTGG intron-variant
rs1001231191 -- 149,752,513(+) GTCCC(C/G)GCGCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for COMMD2 Gene

Variant ID Type Subtype PubMed ID
esv34142 CNV loss 18971310
nsv829754 CNV gain 17160897

Variation tolerance for COMMD2 Gene

Residual Variation Intolerance Score: 45.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.18; 84.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COMMD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
COMMD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COMMD2 Gene

Disorders for COMMD2 Gene

Relevant External Links for COMMD2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COMMD2

No disorders were found for COMMD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COMMD2 Gene

Publications for COMMD2 Gene

  1. COMMD proteins, a novel family of structural and functional homologs of MURR1. (PMID: 15799966) Burstein E … Duckett CS (The Journal of biological chemistry 2005) 2 3 4 60
  2. COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A. (PMID: 25355947) Phillips-Krawczak CA … Burstein E (Molecular biology of the cell 2015) 3 4 60
  3. CCDC22 deficiency in humans blunts activation of proinflammatory NF-κB signaling. (PMID: 23563313) Starokadomskyy P … Burstein E (The Journal of clinical investigation 2013) 3 4 60
  4. COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding. (PMID: 21778237) Mao X … Burstein E (The Journal of biological chemistry 2011) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for COMMD2 Gene

Sources for COMMD2 Gene

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