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Aliases for COMMD10 Gene

Aliases for COMMD10 Gene

  • COMM Domain Containing 10 2 3
  • COMM Domain-Containing Protein 10 3
  • PTD002 3

External Ids for COMMD10 Gene

Previous GeneCards Identifiers for COMMD10 Gene

  • GC05P115497
  • GC05P115448
  • GC05P110601

Summaries for COMMD10 Gene

GeneCards Summary for COMMD10 Gene

COMMD10 (COMM Domain Containing 10) is a Protein Coding gene.

UniProtKB/Swiss-Prot for COMMD10 Gene

  • May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COMMD10 Gene

Genomics for COMMD10 Gene

Regulatory Elements for COMMD10 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for COMMD10 Gene

116,084,991 bp from pter
116,412,762 bp from pter
327,772 bases
Plus strand

Genomic View for COMMD10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COMMD10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COMMD10 Gene

Proteins for COMMD10 Gene

  • Protein details for COMMD10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    COMM domain-containing protein 10
    Protein Accession:
    Secondary Accessions:
    • D3DT07
    • Q9P077

    Protein attributes for COMMD10 Gene

    202 amino acids
    Molecular mass:
    22966 Da
    Quaternary structure:
    • Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with RELA, RELB, NFKB1/p105, NFKB2/p100. Interacts with CCDC22, CCDC93, SCNN1B, CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL7.
    • Sequence=AAF28983.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for COMMD10 Gene

Proteomics data for COMMD10 Gene at MOPED

Post-translational modifications for COMMD10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for COMMD10 Gene

Antibody Products

No data available for DME Specific Peptides for COMMD10 Gene

Domains for COMMD10 Gene

Gene Families for COMMD10 Gene

Protein Domains for COMMD10 Gene


Suggested Antigen Peptide Sequences for COMMD10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 COMM domain.
  • Contains 1 COMM domain.
genes like me logo Genes that share domains with COMMD10: view

Function for COMMD10 Gene

Molecular function for COMMD10 Gene

UniProtKB/Swiss-Prot Function:
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966).

Gene Ontology (GO) - Molecular Function for COMMD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15799966
genes like me logo Genes that share ontologies with COMMD10: view

Phenotypes for COMMD10 Gene

MGI mutant phenotypes for COMMD10:
inferred from 1 alleles
GenomeRNAi human phenotypes for COMMD10:
genes like me logo Genes that share phenotypes with COMMD10: view

Animal Model Products

CRISPR Products

miRNA for COMMD10 Gene

miRTarBase miRNAs that target COMMD10

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COMMD10

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for COMMD10 Gene

Localization for COMMD10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COMMD10 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for COMMD10 Gene COMPARTMENTS Subcellular localization image for COMMD10 gene
Compartment Confidence
cytosol 2
nucleus 2
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for COMMD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with COMMD10: view

Pathways for COMMD10 Gene

SuperPathways for COMMD10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for COMMD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with COMMD10: view

No data available for Pathways by source for COMMD10 Gene

Transcripts for COMMD10 Gene

Unigene Clusters for COMMD10 Gene

COMM domain containing 10:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COMMD10

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COMMD10 Gene

No ASD Table

Relevant External Links for COMMD10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COMMD10 Gene

mRNA expression in normal human tissues for COMMD10 Gene

Protein differential expression in normal tissues for COMMD10 Gene

This gene is overexpressed in Bone marrow stromal cell (8.1) and Monocytes (7.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COMMD10 Gene

SOURCE GeneReport for Unigene cluster for COMMD10 Gene Hs.483136

mRNA Expression by UniProt/SwissProt for COMMD10 Gene

Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with COMMD10: view

Expression partners for COMMD10 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for COMMD10 Gene

Orthologs for COMMD10 Gene

This gene was present in the common ancestor of animals.

Orthologs for COMMD10 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia COMMD10 35
  • 92.41 (n)
  • 93.07 (a)
COMMD10 36
  • 93 (a)
(Canis familiaris)
Mammalia COMMD10 35
  • 90.76 (n)
  • 92.57 (a)
COMMD10 36
  • 93 (a)
(Mus musculus)
Mammalia Commd10 35
  • 85.15 (n)
  • 89.11 (a)
Commd10 16
Commd10 36
  • 89 (a)
(Pan troglodytes)
Mammalia COMMD10 35
  • 99.34 (n)
  • 99.01 (a)
COMMD10 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Commd10 35
  • 86.47 (n)
  • 89.11 (a)
(Monodelphis domestica)
Mammalia COMMD10 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia COMMD10 36
  • 80 (a)
(Gallus gallus)
Aves COMMD10 35
  • 72.29 (n)
  • 75.3 (a)
COMMD10 36
  • 63 (a)
(Anolis carolinensis)
Reptilia COMMD10 36
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia commd10 35
  • 74.58 (n)
  • 75.76 (a)
Str.16149 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.21108 35
(Danio rerio)
Actinopterygii commd10 35
  • 60.1 (n)
  • 61.14 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2371 36
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5208 36
  • 44 (a)
Species with no ortholog for COMMD10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COMMD10 Gene

Gene Tree for COMMD10 (if available)
Gene Tree for COMMD10 (if available)

Paralogs for COMMD10 Gene

No data available for Paralogs for COMMD10 Gene

Variants for COMMD10 Gene

Sequence variations from dbSNP and Humsavar for COMMD10 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs28125 -- 116,278,065(-) TGTTA(C/T)TATCT intron-variant
rs33267 -- 116,237,846(-) AGGAG(C/T)TGATG intron-variant
rs37182 -- 116,256,367(-) ATAAT(A/C)ATGTC intron-variant
rs153610 -- 116,244,684(+) gaaaa(C/G)AGCCA intron-variant
rs153611 -- 116,244,815(+) ctatg(G/T)aatcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COMMD10 Gene

Variant ID Type Subtype PubMed ID
nsv515611 CNV Gain+Loss 19592680
dgv6297n71 CNV Gain 21882294
esv34146 CNV Loss 18971310
nsv527320 CNV Loss 19592680
nsv509991 CNV Loss 20534489
nsv4967 CNV Insertion 18451855
esv2665054 CNV Deletion 23128226
esv2730631 CNV Deletion 23290073
esv1348644 CNV Deletion 17803354
dgv1001e201 CNV Deletion 23290073
nsv882739 CNV Gain 21882294
dgv6298n71 CNV Loss 21882294
nsv882742 CNV Loss 21882294
esv2730633 CNV Deletion 23290073
esv2552964 CNV Insertion 19546169
nsv10744 CNV Loss 18304495
esv267982 CNV Insertion 20981092
esv273003 CNV Insertion 20981092
esv33800 CNV Loss 17666407
nsv882743 CNV Loss 21882294
esv2670584 CNV Deletion 23128226
esv32605 CNV Gain 17666407
esv2632290 CNV Deletion 19546169
esv2730634 CNV Deletion 23290073
dgv1842e1 CNV Complex 17122850
esv33867 CNV Gain 17666407
nsv524812 CNV Loss 19592680
nsv10745 CNV Loss 18304495
nsv527484 CNV Loss 19592680
nsv823185 CNV Loss 20364138
esv2752058 CNV Loss 17911159
nsv519321 CNV Loss 19592680
nsv462401 CNV Loss 19166990
nsv521050 CNV Loss 19592680
dgv6299n71 CNV Gain 21882294
nsv882746 CNV Loss 21882294
dgv6300n71 CNV Loss 21882294
esv34428 CNV Loss 17911159
dgv1843e1 CNV Complex 17122850
esv2677603 CNV Deletion 23128226
nsv328049 CNV Loss 16902084
esv2422101 CNV Deletion 20811451
nsv462402 CNV Loss 19166990
nsv517704 CNV Loss 19592680
nsv818377 CNV Loss 17921354
dgv1844e1 CNV Complex 17122850
esv34342 CNV Loss 17911159
essv8988 CNV CNV 17122850
nsv442961 CNV CNV 18776908
nsv514321 CNV Loss 21397061
nsv10746 CNV Loss 18304495

Relevant External Links for COMMD10 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COMMD10 Gene

Disorders for COMMD10 Gene

Relevant External Links for COMMD10

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for COMMD10 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for COMMD10 Gene

Publications for COMMD10 Gene

  1. COMMD proteins, a novel family of structural and functional homologs of MURR1. (PMID: 15799966) Burstein E. … Duckett C.S. (J. Biol. Chem. 2005) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. CCDC22 deficiency in humans blunts activation of proinflammatory NF-I_B signaling. (PMID: 23563313) Starokadomskyy P. … Burstein E. (J. Clin. Invest. 2013) 3 4
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48

Products for COMMD10 Gene

Sources for COMMD10 Gene

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