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Aliases for COMMD10 Gene

Aliases for COMMD10 Gene

  • COMM Domain Containing 10 2 3 5
  • PTD002 3

External Ids for COMMD10 Gene

Previous GeneCards Identifiers for COMMD10 Gene

  • GC05P115497
  • GC05P115448
  • GC05P110601

Summaries for COMMD10 Gene

GeneCards Summary for COMMD10 Gene

COMMD10 (COMM Domain Containing 10) is a Protein Coding gene.

UniProtKB/Swiss-Prot for COMMD10 Gene

  • May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COMMD10 Gene

Genomics for COMMD10 Gene

Regulatory Elements for COMMD10 Gene

Enhancers for COMMD10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around COMMD10 on UCSC Golden Path with GeneCards custom track

Promoters for COMMD10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around COMMD10 on UCSC Golden Path with GeneCards custom track

Genomic Location for COMMD10 Gene

Chromosome:
5
Start:
116,083,645 bp from pter
End:
116,412,762 bp from pter
Size:
329,118 bases
Orientation:
Plus strand

Genomic View for COMMD10 Gene

Genes around COMMD10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COMMD10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COMMD10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COMMD10 Gene

Proteins for COMMD10 Gene

  • Protein details for COMMD10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6G5-COMDA_HUMAN
    Recommended name:
    COMM domain-containing protein 10
    Protein Accession:
    Q9Y6G5
    Secondary Accessions:
    • D3DT07
    • Q9P077

    Protein attributes for COMMD10 Gene

    Size:
    202 amino acids
    Molecular mass:
    22966 Da
    Quaternary structure:
    • Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with RELA, RELB, NFKB1/p105, NFKB2/p100. Interacts with CCDC22, CCDC93, SCNN1B, CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL7.
    SequenceCaution:
    • Sequence=AAF28983.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for COMMD10 Gene

Proteomics data for COMMD10 Gene at MOPED

Post-translational modifications for COMMD10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for COMMD10 Gene

No data available for DME Specific Peptides for COMMD10 Gene

Domains & Families for COMMD10 Gene

Gene Families for COMMD10 Gene

Protein Domains for COMMD10 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for COMMD10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6G5

UniProtKB/Swiss-Prot:

COMDA_HUMAN :
  • Contains 1 COMM domain.
Domain:
  • Contains 1 COMM domain.
genes like me logo Genes that share domains with COMMD10: view

Function for COMMD10 Gene

Molecular function for COMMD10 Gene

UniProtKB/Swiss-Prot Function:
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966).

Phenotypes for COMMD10 Gene

MGI mutant phenotypes for COMMD10:
inferred from 1 alleles
GenomeRNAi human phenotypes for COMMD10:
genes like me logo Genes that share phenotypes with COMMD10: view

Animal Models for COMMD10 Gene

MGI Knock Outs for COMMD10:

Animal Model Products

CRISPR Products

miRNA for COMMD10 Gene

miRTarBase miRNAs that target COMMD10

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for COMMD10 Gene

Localization for COMMD10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COMMD10 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COMMD10 Gene COMPARTMENTS Subcellular localization image for COMMD10 gene
Compartment Confidence
nucleus 4
cytosol 2
endoplasmic reticulum 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for COMMD10 Gene

Pathways & Interactions for COMMD10 Gene

SuperPathways for COMMD10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for COMMD10 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for COMMD10 Gene

Drugs & Compounds for COMMD10 Gene

No Compound Related Data Available

Transcripts for COMMD10 Gene

Unigene Clusters for COMMD10 Gene

COMM domain containing 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COMMD10 Gene

No ASD Table

Relevant External Links for COMMD10 Gene

GeneLoc Exon Structure for
COMMD10
ECgene alternative splicing isoforms for
COMMD10

Expression for COMMD10 Gene

mRNA expression in normal human tissues for COMMD10 Gene

Protein differential expression in normal tissues from HIPED for COMMD10 Gene

This gene is overexpressed in Bone marrow stromal cell (8.1) and Monocytes (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for COMMD10 Gene



SOURCE GeneReport for Unigene cluster for COMMD10 Gene Hs.483136

mRNA Expression by UniProt/SwissProt for COMMD10 Gene

Q9Y6G5-COMDA_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with COMMD10: view

Protein tissue co-expression partners for COMMD10 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for COMMD10 Gene

Orthologs for COMMD10 Gene

This gene was present in the common ancestor of animals.

Orthologs for COMMD10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia COMMD10 35
  • 92.41 (n)
  • 93.07 (a)
COMMD10 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COMMD10 35
  • 90.76 (n)
  • 92.57 (a)
COMMD10 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Commd10 35
  • 85.15 (n)
  • 89.11 (a)
Commd10 16
Commd10 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia COMMD10 35
  • 99.34 (n)
  • 99.01 (a)
COMMD10 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Commd10 35
  • 86.47 (n)
  • 89.11 (a)
oppossum
(Monodelphis domestica)
Mammalia COMMD10 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COMMD10 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves COMMD10 35
  • 72.29 (n)
  • 75.3 (a)
COMMD10 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COMMD10 36
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia commd10 35
  • 74.58 (n)
  • 75.76 (a)
Str.16149 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.21108 35
zebrafish
(Danio rerio)
Actinopterygii commd10 35
  • 60.1 (n)
  • 61.14 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2371 36
  • 21 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5208 36
  • 44 (a)
OneToOne
Species with no ortholog for COMMD10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COMMD10 Gene

ENSEMBL:
Gene Tree for COMMD10 (if available)
TreeFam:
Gene Tree for COMMD10 (if available)

Paralogs for COMMD10 Gene

No data available for Paralogs for COMMD10 Gene

Variants for COMMD10 Gene

Sequence variations from dbSNP and Humsavar for COMMD10 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1129495 - 116,092,684(+) GAGAA(G/T)TCTGG nc-transcript-variant, reference, missense
rs712561 -- 116,217,248(-) TGTTT(A/C)TGGAA intron-variant
rs712563 -- 116,257,928(-) GAAAT(G/T)GGGTA intron-variant
rs712564 -- 116,266,718(-) gctgg(A/G)ttcag intron-variant
rs712565 -- 116,269,501(+) GTTCA(A/C)GTTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COMMD10 Gene

Variant ID Type Subtype PubMed ID
nsv515611 CNV Gain+Loss 19592680
dgv6297n71 CNV Gain 21882294
esv34146 CNV Loss 18971310
nsv527320 CNV Loss 19592680
nsv509991 CNV Loss 20534489
nsv4967 CNV Insertion 18451855
esv2665054 CNV Deletion 23128226
esv2730631 CNV Deletion 23290073
esv1348644 CNV Deletion 17803354
dgv1001e201 CNV Deletion 23290073
nsv882739 CNV Gain 21882294
dgv6298n71 CNV Loss 21882294
nsv882742 CNV Loss 21882294
esv2730633 CNV Deletion 23290073
esv2552964 CNV Insertion 19546169
nsv10744 CNV Loss 18304495
esv267982 CNV Insertion 20981092
esv273003 CNV Insertion 20981092
esv33800 CNV Loss 17666407
nsv882743 CNV Loss 21882294
esv2670584 CNV Deletion 23128226
esv32605 CNV Gain 17666407
esv2632290 CNV Deletion 19546169
esv2730634 CNV Deletion 23290073
dgv1842e1 CNV Complex 17122850
esv33867 CNV Gain 17666407
nsv524812 CNV Loss 19592680
nsv10745 CNV Loss 18304495
nsv527484 CNV Loss 19592680
nsv823185 CNV Loss 20364138
esv2752058 CNV Loss 17911159
nsv519321 CNV Loss 19592680
nsv462401 CNV Loss 19166990
nsv521050 CNV Loss 19592680
dgv6299n71 CNV Gain 21882294
nsv882746 CNV Loss 21882294
dgv6300n71 CNV Loss 21882294
esv34428 CNV Loss 17911159
dgv1843e1 CNV Complex 17122850
esv2677603 CNV Deletion 23128226
nsv328049 CNV Loss 16902084
esv2422101 CNV Deletion 20811451
nsv462402 CNV Loss 19166990
nsv517704 CNV Loss 19592680
nsv818377 CNV Loss 17921354
dgv1844e1 CNV Complex 17122850
esv34342 CNV Loss 17911159
essv8988 CNV CNV 17122850
nsv442961 CNV CNV 18776908
nsv514321 CNV Loss 21397061
nsv10746 CNV Loss 18304495

Variation tolerance for COMMD10 Gene

Residual Variation Intolerance Score: 56.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.83; 73.86% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for COMMD10 Gene

Disorders for COMMD10 Gene

Relevant External Links for COMMD10

Genetic Association Database (GAD)
COMMD10
Human Genome Epidemiology (HuGE) Navigator
COMMD10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COMMD10

No disorders were found for COMMD10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COMMD10 Gene

Publications for COMMD10 Gene

  1. COMMD proteins, a novel family of structural and functional homologs of MURR1. (PMID: 15799966) Burstein E. … Duckett C.S. (J. Biol. Chem. 2005) 2 3 4 67
  2. COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A. (PMID: 25355947) Phillips-Krawczak C.A. … Burstein E. (Mol. Biol. Cell 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for COMMD10 Gene

Sources for COMMD10 Gene

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