COMMD10 Gene
protein-coding GIFtS: 45
GCID: GC05P115448
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COMM domain containing 10
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Aliases
for COMMD10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| COMM Domain Containing 101 2 | | PTD0021 2 | | COMM Domain-Containing Protein 102 |
Export aliases for COMMD10 gene to outside databasesPrevious GC identifers: GC05P115497 GC05P110601 |
Summaries
for COMMD10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for COMMD10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_034772.6
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the COMMD10 gene promoter:
C/EBPbeta Pax-6 Lmo2 CUTL1 PPAR-gamma1 POU2F1 POU2F1a Chx10 PPAR-gamma2 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for COMMD10
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COMMD10 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q23.1 Ensembl cytogenetic band: 5q23.1 HGNC cytogenetic band: 5q23.1COMMD10 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P115448: view genomic region
(about GC identifiers)
Start:
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115,420,688 bp from pter |
End:
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115,748,459 bp from pter |
Size:
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327,772 bases |
Orientation:
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plus strand |
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Proteins
for COMMD10 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: COMDA_HUMAN, Q9Y6G5 (See
protein sequence)Recommended Name: COMM domain-containing protein 10 Size: 202 amino acids; 22966 Da
Subunit: Interacts (via COMM domain) with COMMD1 (via COMM domain)
Sequence caution: Sequence=AAF28983.1; Type=Erroneous initiation;
Secondary accessions: D3DT07 Q9P077Explore the universe of human proteins at neXtProt for COMMD10: NX_Q9Y6G5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y6G5
COMMD10 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057228.1
ENSEMBL proteins: ENSP00000274458 ENSP00000422448 ENSP00000427319 ENSP00000424611
Human Recombinant Protein Products:
COMMD10 Antibody Products:
Assay Products for COMMD10: |
Protein
Domains /
Families
for COMMD10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
COMMD10 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y6G5ProtoNet protein and cluster: Q9Y6G5 1 Blocks protein family: IPB009886 HCaRG
UniProtKB/Swiss-Prot: COMDA_HUMAN, Q9Y6G5Similarity: Contains 1 COMM domain |
Function
for COMMD10 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD10 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD10
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: COMMD10 (NM_016144) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COMMD10 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COMMD10 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COMMD10 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
COMMD10 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for COMMD10:
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Pathways & Interactions
for COMMD10 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for COMMD10
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/6 Interacting proteins for COMMD10 (Q9Y6G53 ENSP000002744584) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
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Drugs & Compounds
for COMMD10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for COMMD10
Search CenterWatch for drugs/clinical trials and news about COMMD10 / COMDA
|
Transcripts
for COMMD10 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for COMMD10 gene: NM_016144.2 Unigene Cluster for COMMD10: COMM domain containing 10 Hs.483136 [show with all ESTs]Unigene Representative Sequence: BF6675486 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000274458(uc003krt.1) ENST00000507356 ENST00000515539 ENST00000506589
ENST00000508250 ENST00000503424
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD10 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD10
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: COMMD10 (NM_016144) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for COMMD10 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COMMD10 |
Additional cDNA sequence: AF078857.1 AF161423.1 AK002147.1 AY542165.1 BC005179.1 10 DOTS entries: DT.214565 DT.407444 DT.95173070 DT.100748842 DT.95173071 DT.97826679 DT.40122488 DT.91759658 DT.95173074 DT.95173075 24/250 AceView cDNA sequences (see all 250): AI435606 AI627623 AW014189 BF740047 AL518961 AI276133 AW590621 AL699080 BC013250 CB123372 BE880244 AI468390 BE328209 BU688202 AW662195 AI309751 AA732326 CA444928 T35284 CR611628 H92882 AI052643 AA252152 CA449363
GeneLoc Exon Structure
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Expression
for COMMD10 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| COMMD10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATAAAATTA
About this image
See COMMD10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for COMMD10
SOURCE GeneReport for Unigene cluster: Hs.483136
UniProtKB/Swiss-Prot: COMDA_HUMAN, Q9Y6G5Tissue specificity: Ubiquitous
SABiosciences Custom PCR Arrays for COMMD10
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COMMD10
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat COMMD10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COMMD10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COMMD10 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COMMD10 |
Orthologs
for COMMD10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for COMMD10 gene from 6/21 species (see all 21) About this table
ENSEMBL Gene Tree for COMMD10 (if available)
TreeFam Gene Tree for COMMD10 (if available) |
Paralogs
for COMMD10 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for COMMD10 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for COMMD10 (115420688 - 115670688 bp, first 250kb of COMMD10)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 21 variations for COMMD10
15/17 CNVs (see all 17): 51536 38589 2597 9027 9026 48002 9025 32745 51539 93201 32746 99268 51538 10129 2596
4 Indels: 11243 11244 27778 99267 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COMMD10 |
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Disorders
/ Diseases
for COMMD10 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 COMMD10 for disorders About MalaCards
COMMD10 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: COMMD10 (3 documents)
Export disorders for COMMD10 gene to outside databases
|
Publications
for COMMD10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for COMMD10 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with COMMD10) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- COMMD proteins, a novel family of structural and functional homologs of MURR1. (PubMed id 15799966)1, 2, 3 Burstein E....Duckett C.S. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
- A genome-wide association study of inflammatory biomar ker changes in response to fenofibrate treatment in the Genetics of Lipid Loweri ng Drug and Diet Network. (PubMed id 22228203)1 Aslibekyan S....Arnett D.K. (2012)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared wit h bipolar disorder. (PubMed id 22688191)1 Bergen S.E....Sullivan P.F. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
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External Searches for COMMD10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing COMMD10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing COMMD10 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing COMMD10 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for COMMD10 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for COMMD10 gene:
Search GeneIP for patents involving COMMD10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for COMMD10 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for COMMD10 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COMMD10 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COMMD10 | | | OriGene Protein Over-expression Lysate for COMMD10 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for COMMD10 | | OriGene 3'-UTR Clone for COMMD10 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD10 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COMMD10 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for COMMD10 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for COMMD10 | | OriGene Custom Protein Services for COMMD10 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat COMMD10 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COMMD10 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COMMD10 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COMMD10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COMMD10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COMMD10 |
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| | | | Search Tocris compounds for COMMD10 |
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 | | | COMMD10 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COMMD10 |
|  |  |  | | | | ThermoFisher Antibodies for COMMD10 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COMMD10 |
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