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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

COMMD1 Gene

protein-coding   GIFtS: 60
GCID: GC02P062115

copper metabolism (Murr1) domain containing 1

(Previous name: chromosome 2 open reading frame 5 (MURR1) )
(Previous symbol: C2orf5)
 Explore 5 diseases affiliated with
COMMD1 via our new
 Human Malady Compendium 
Biological research products
for COMMD1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Copper Metabolism (Murr1) Domain Containing 11 2     MGC271551
MURR11 2 3 5     Chromosome 2 Open Reading Frame 5 (MURR1)1
C2orf51 2 3     COMM Domain-Containing Protein 12
Protein Murr12 3     Copper Metabolism Gene MURR12

External Ids:    HGNC: 230241   Entrez Gene: 1506842   Ensembl: ENSG000001731637   OMIM: 6072385   UniProtKB: Q8N6683   

Export aliases for COMMD1 gene to outside databases

Previous GC identifers: GC02P062108 GC02P062044 GC02P061986 GC02P061871


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for COMMD1:
COMMD1 is a regulator of copper homeostasis, sodium uptake, and NF-kappa-B (see MIM 164011) signaling (de Bie et al.,
2005 (PubMed 16267171)).(supplied by OMIM, Sep 2009)

UniProtKB/Swiss-Prot: COMD1_HUMAN, Q8N668
Function: Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates
NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion
homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within
hepatocytes

Gene Wiki entry for COMMD1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the COMMD1 gene promoter:
         TBP   STAT1   C/EBPbeta   STAT1alpha   GATA-1   PPAR-gamma1   TFIID   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOMMD1 promoter sequence
   Search SABiosciences Chromatin IP Primers for COMMD1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COMMD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p15   Ensembl cytogenetic band:  2p15   HGNC cytogenetic band: 2p15

COMMD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COMMD1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P062115:  view genomic region     (about GC identifiers)

Start:
62,115,859 bp from pter      End:
62,374,382 bp from pter
Size:
258,524 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: COMD1_HUMAN, Q8N668 (See protein sequence)
Recommended Name: COMM domain-containing protein 1  
Size: 190 amino acids; 21178 Da
Subunit: Monomer and homodimer. Interacts (via COMM domain) with COMMD2, COMMD3, COMMD4, COMMD5, COMMD6, COMMD7, COMMD8
and COMMD10 (via COMM domain). Identified in a complex with an E3 ubiquitin ligase complex composed of TCEB1/elongin
C, CUL2, SOCS1 and RBX1. Interacts directly with SOCS1 and CUL2. Interacts directly the N-terminal region of ATP7B.
Interacts with CCS, CDKN2A, RELA and NFKBIB. Identified in a complex with NF-kappa-B. Interacts with CLU
Subcellular location: Nucleus. Cytoplasm. Note=Shuttles between nucleus and cytosol. Detected in perinuclear foci that
may be aggresomes containing misfolded, ubiquitinated proteins
1 PDB 3D structure from and Proteopedia for COMMD1:
2H2M (3D)    
Secondary accessions: Q96GS0

Explore the universe of human proteins at neXtProt for COMMD1: NX_Q8N668

Post-translational modifications:

  • Ubiquitinated; undergoes both 'Lys-63'- and 'Lys-48'-linked polyubiquitination. Ubiquitinated by XIAP, leading to its
  • proteasomal degradation1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8N668

  • COMMD1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_689729.1  
    ENSEMBL proteins: 
     ENSP00000416997   ENSP00000308236   ENSP00000398727   ENSP00000401236   ENSP00000413207  
     ENSP00000410050   ENSP00000438961  

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    ProSpec Recombinant Protein for COMMD1
    Uscn Proteins for COMMD1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0030054cell junction IDA--
    GO:0031462Cul2-RING ubiquitin ligase complex IDA17183367


    COMMD1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    COMMD1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR017920 COMM
     IPR009886 HCaRG

    Graphical View of Domain Structure for InterPro Entry Q8N668

    ProtoNet protein and cluster: Q8N668

    1 Blocks protein family: IPB009886 HCaRG

    UniProtKB/Swiss-Prot: COMD1_HUMAN, Q8N668
    Similarity: Contains 1 COMM domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: COMD1_HUMAN, Q8N668
    Function: Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates
    NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion
    homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within
    hepatocytes

    miRNA
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COMMD1

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005507copper ion binding IDA17309234
    GO:0005515protein binding IPI15799966
    GO:0042802identical protein binding IPI15799966
    GO:0042803protein homodimerization activity IPI15799966


    COMMD1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for COMMD1:
     Decreased viability with pacli 

    Animal Models:
         Mouse knock-out Commd1tm1Bvds for COMMD1
         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Commd1):
     cardiovascular system  embryogenesis  growth/size  homeostasis/metabolism  liver/biliary system 
     mortality/aging  nervous system 

    COMMD1 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)
    wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)1.00
    Regulation of CFTR activity (norm and CF)0.38
    2TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway1.00
    3Clathrin-dependent protein traffic
    wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)0.37

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3 GeneGo (Thomson Reuters) Pathways for COMMD1
        wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
    Regulation of CFTR activity (norm and CF)
    wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)

    1 BioSystems Pathway for COMMD1 
        TNF-alpha/NF-kB Signaling Pathway


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for COMMD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/47 Interacting proteins for COMMD1 (Q8N6681, 2, 3 ENSP000003082364) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CUL2Q136172, 3, ENSP000003638804MINT-4140802 MINT-4140816 MINT-4140831 I2D: score=3 STRING: ENSP00000363880
    SCNN1DP511721, 3, ENSP000003215944EBI-1550112,EBI-2547114 I2D: score=2 STRING: ENSP00000321594
    RELBQ012011, 3, ENSP000002214524EBI-1550112,EBI-357837 I2D: score=1 STRING: ENSP00000221452
    SOCS1O155242, 3, ENSP000003294184MINT-4140906 MINT-4140761 MINT-4140776 I2D: score=3 STRING: ENSP00000329418
    RELAQ042061, 3, ENSP000003842734EBI-1550112,EBI-73886 I2D: score=5 STRING: ENSP00000384273
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031398positive regulation of protein ubiquitination IDA17183367
    GO:0032088negative regulation of NF-kappaB transcription factor activity IMP17183367
    GO:0032434regulation of proteasomal ubiquitin-dependent protein catabolic process IMP17183367
    GO:0055070copper ion homeostasis IDA14685266


    COMMD1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    COMMD1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for COMMD1

    1 HMDB Compound for COMMD1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CopperCu (see all 2)7440-50-8--
    1 Novoseek chemical compound relationship for COMMD1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    copper 71.4 52 17309234 (6), 16868807 (4), 15205742 (3), 14568250 (3) (see all 13)

    Search CenterWatch for drugs/clinical trials and news about COMMD1 / COMD1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for COMMD1 gene: 
    NM_152516.2  

    Unigene Cluster for COMMD1:

    Copper metabolism (Murr1) domain containing 1
    Hs.468702  [show with all ESTs]
    Unigene Representative Sequence: BG481459
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000472729 ENST00000445644 ENST00000471704 ENST00000311832(uc002sbp.3)
    ENST00000455659 ENST00000458337 ENST00000427417 ENST00000444166 ENST00000538736


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    Additional cDNA sequence: 

    AB178811.1 AK223607.1 AK294203.1 BC009266.2 BC022046.1 D85433.1 

    12 DOTS entries:

    DT.95269398  DT.100837561  DT.121023375  DT.100813212  DT.415557  DT.121023330  DT.121023198  DT.121023392 
    DT.100742402  DT.121023370  DT.121023384  DT.91745499 

    24/177 AceView cDNA sequences (see all 177):

    BF440009 BQ631893 AA864460 AA452108 CA432882 BU736794 F30945 AA613846 
    AI186515 BQ949150 BF689598 AA400293 AA412516 CR603473 AV716714 BM785232 
    AA345612 AI630376 AB178811 AA401423 D85433 AI360090 BM702483 CD368588 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for COMMD1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b
    SP1:                              
    SP2:              -               


    ECgene alternative splicing isoforms for COMMD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    COMMD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATCCCTCCCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See COMMD1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for COMMD1

    SOURCE GeneReport for Unigene cluster: Hs.468702

    UniProtKB/Swiss-Prot: COMD1_HUMAN, Q8N668
    Tissue specificity: Ubiquitous. Highest expression in the liver, with lower expression in brain, lung, placenta,
    pancreas, small intestine, heart, skeletal muscle, kidney and placenta

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COMMD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for COMMD1 gene from 5/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Commd11 , 5 COMM domain containing 11, 5 85.87(n)1
    86.41(a)1
      11 (14.22 cM)5
    178461  NM_144514.21  NP_653097.21 
     228347445 
    chicken
    (Gallus gallus)
    Aves COMMD11 copper metabolism (Murr1) domain containing 1 72.61(n)
    71.35(a)
      769006  XM_001231775.2  XP_001231776.1 
    lizard
    (Anolis carolinensis)
    Reptilia COMMD16
    --
    56(a)
    1 ↔ 1
    1(121534859-121555434)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.109252 Xenopus laevis transcribed sequences 72.53(n)    BJ621252.1 
    zebrafish
    (Danio rerio)
    Actinopterygii commd11 copper metabolism (Murr1) domain containing 1 59.05(n)
    53.14(a)
      692293  NM_001045265.1  NP_001038730.1 


    ENSEMBL Gene Tree for COMMD1 (if available)
    TreeFam Gene Tree for COMMD1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3479 NCBI SNPs in COMMD1 are shown (see all 3479    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1854511121,2
    --62130827(+) GGACTA/GCAGAC 1 -- us2k10--------
    rs1902561771,2
    --62130913(+) CTCAGA/GTGATC 1 -- us2k10--------
    rs1827588801,2
    --62130916(+) AGGTGA/TTCCAC 1 -- us2k10--------
    rs728917401,2
    C,--62130922(+) TCCACC/TCACCT 1 -- us2k10--------
    rs134150471,2
    C,--62131381(+) GACCTC/TGTGAT 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs1876896881,2
    --62131389(+) GATCCA/GTCTGC 1 -- us2k10--------
    rs1497572031,2
    --62131436(+) CCACCA/GTGCCC 1 -- us2k10--------
    rs1144773261,2
    F,--62131441(+) GTGCCC/TGGCAA 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1153679971,2
    F,--62131482(+) ATACAG/AAATAT 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1927583061,2
    --62131519(+) AGGAAA/GGAGTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for COMMD1 (62115859 - 62365859 bp, first 250kb of COMMD1)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for COMMD1
         2 CNVs: 50541 48014
    Human Gene Mutation Database (HGMD): COMMD1

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    COMMD1 for disorders           About GeneDecksing

    OMIM gene information: 607238    OMIM disorders: --

    5 diseases for COMMD1:    About MalaCards
    wilson disease    menkes disease    prostate cancer    prostatitis
    hepatitis

    1 disease from the University of Copenhagen DISEASES database for COMMD1:
    Wilson disease

    2 Novoseek disease relationships for COMMD1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wilson disease 83.9 16 15205742 (4), 16610028 (4), 16868807 (3), 16649058 (1) (see all 6)
    cirrhosis 25.7 1 16649058 (1)

    Human Genome Epidemiology (HuGE) Navigator: COMMD1 (3 documents)

    Export disorders for COMMD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for COMMD1 gene, integrated from 9 sources (see all 57):
    (articles sorted by number of sources associating them with COMMD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a new copper metabolism gene by positional cloning in a purebred dog population. (PubMed id 11809725)1, 2, 3, 9 van De Sluis B.A.J....Wijmenga C. (2002)
    2. Characterization and copper binding properties of human COMMD1 (MURR1). (PubMed id 17309234)1, 2, 9 Narindrasorasak S....Sarkar B. (2007)
    3. Analysis of the human homologue of the canine copper toxicosis gene MURR1 in Wilson disease patients. (PubMed id 15205742)1, 2, 9 Stuehler B.... Schaefer M. (2004)
    4. The canine copper toxicosis gene MURR1 does not cause non-Wilsonian hepatic copper toxicosis. (PubMed id 12547404)1, 2, 9 Mueller T.... Wijmenga C. (2003)
    5. The copper toxicosis gene product Murr1 directly interacts with the Wilson disease protein. (PubMed id 12968035)1, 2, 9 Tao T.Y.... Gitlin J.D. (2003)
    6. Clusterin facilitates COMMD1 and I-kappaB degradation to enhance NF-kappaB activity in prostate cancer cells. (PubMed id 20068069)1, 2 Zoubeidi A....Gleave M.E. (2010)
    7. Cu,Zn superoxide dismutase maturation and activity ar e regulated by COMMD1. (PubMed id 20595380)1, 2 Vonk W.I....Klomp L.W. (2010)
    8. Nucleolar targeting of RelA(p65) is regulated by COMM D1-dependent ubiquitination. (PubMed id 20048074)1, 2 Thoms H.C....Stark L.A. (2010)
    9. Tumor suppressor ARF promotes non-classic proteasome-independent polyubiquitination of COMMD1. (PubMed id 18305112)1, 2 Huang Y....Li H.Y. (2008)
    10. Solution structure of the COMMD1 N-terminal domain. (PubMed id 17097678)1, 2 Sommerhalter M....Rosenzweig A.C. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 150684 HGNC: 23024 AceView: COMMD1 Ensembl:ENSG00000173163 euGenes: HUgn150684
    ECgene: COMMD1 H-InvDB: COMMD1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for COMMD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for COMMD1 gene:
    Search GeneIP for patents involving COMMD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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