Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

COMMD1 Gene

protein-coding   GIFtS: 62
GCID: GC02P062115

Copper Metabolism (Murr1) Domain Containing 1

(Previous name: chromosome 2 open reading frame 5 (MURR1))
(Previous symbol: C2orf5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Copper Metabolism (Murr1) Domain Containing 11 2     Protein Murr12 3
C2orf51 2 3     Chromosome 2 Open Reading Frame 5 (MURR1)1
MURR12 3 5     COMM Domain-Containing Protein 12
Copper Metabolism Gene MURR11 2     

External Ids:    HGNC: 230241   Entrez Gene: 1506842   Ensembl: ENSG000001731637   OMIM: 6072385   UniProtKB: Q8N6683   

Export aliases for COMMD1 gene to outside databases

Previous GC identifers: GC02P062108 GC02P062044 GC02P061986 GC02P061871


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for COMMD1 Gene:
COMMD1 is a regulator of copper homeostasis, sodium uptake, and NF-kappa-B (see MIM 164011) signaling (de Bie et
al., 2005 (PubMed 16267171)).(supplied by OMIM, Sep 2009)

GeneCards Summary for COMMD1 Gene: 
COMMD1 (copper metabolism (Murr1) domain containing 1) is a protein-coding gene. Diseases associated with COMMD1 include wilson disease, and menkes disease, and among its related super-pathways are Regulation of CFTR activity (norm and CF) and Clathrin-dependent protein traffic. GO annotations related to this gene include copper ion binding and protein homodimerization activity.

UniProtKB/Swiss-Prot: COMD1_HUMAN, Q8N668
Function: Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation.
Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays
a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper
excretion within hepatocytes

Gene Wiki entry for COMMD1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the COMMD1 gene promoter:
         TBP   STAT1   C/EBPbeta   STAT1alpha   GATA-1   PPAR-gamma1   TFIID   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOMMD1 promoter sequence
   Search SABiosciences Chromatin IP Primers for COMMD1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COMMD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p15   Ensembl cytogenetic band:  2p15   HGNC cytogenetic band: 2p15

COMMD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COMMD1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P062115:  view genomic region     (about GC identifiers)

Start:
62,115,859 bp from pter      End:
62,374,382 bp from pter
Size:
258,524 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: COMD1_HUMAN, Q8N668 (See protein sequence)
Recommended Name: COMM domain-containing protein 1  
Size: 190 amino acids; 21178 Da
Subunit: Monomer and homodimer. Interacts (via COMM domain) with COMMD2, COMMD3, COMMD4, COMMD5, COMMD6, COMMD7,
COMMD8 and COMMD10 (via COMM domain). Identified in a complex with an E3 ubiquitin ligase complex composed of
TCEB1/elongin C, CUL2, SOCS1 and RBX1. Interacts directly with SOCS1 and CUL2. Interacts directly the N-terminal
region of ATP7B. Interacts with CCS, CDKN2A, RELA and NFKBIB. Identified in a complex with NF-kappa-B. Interacts
with CLU
Subcellular location: Nucleus. Cytoplasm. Note=Shuttles between nucleus and cytosol. Detected in perinuclear foci
that may be aggresomes containing misfolded, ubiquitinated proteins
1 PDB 3D structure from and Proteopedia for COMMD1:
2H2M (3D)    
Secondary accessions: Q96GS0

Explore the universe of human proteins at neXtProt for COMMD1: NX_Q8N668

Explore proteomics data for COMMD1 at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated; undergoes both 'Lys-63'- and 'Lys-48'-linked polyubiquitination. Ubiquitinated by XIAP, leading to
    its proteasomal degradation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N668

  • COMMD1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    COMMD1 Protein Expression
    REFSEQ proteins: NP_689729.1  
    ENSEMBL proteins: 
     ENSP00000416997   ENSP00000308236   ENSP00000398727   ENSP00000401236   ENSP00000413207  
     ENSP00000410050   ENSP00000438961  

    Human Recombinant Protein Products for COMMD1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for COMMD1
    OriGene Protein Over-expression Lysate for COMMD1
    OriGene MassSpec for COMMD1 
    OriGene Custom Protein Services for COMMD1
    GenScript Custom Purified and Recombinant Proteins Services for COMMD1
    Novus Biologicals COMMD1 Proteins
    Novus Biologicals COMMD1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for COMMD1
    Cloud-Clone Corp. Proteins for COMMD1 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0030054cell junction IDA--
    GO:0031462Cul2-RING ubiquitin ligase complex IDA17183367

    COMMD1 for ontologies           About GeneDecksing



    COMMD1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for COMMD1
    OriGene Antibodies for COMMD1
    OriGene Custom Antibody Services for COMMD1
    GenScript Custom Superior Antibodies Services for COMMD1
    Novus Biologicals COMMD1 Antibodies
    Abcam antibodies for COMMD1
    Cloud-Clone Corp. Antibodies for COMMD1 
    Search ThermoFisher Antibodies for COMMD1
    LSBio Antibodies in human, mouse, rat for COMMD1 

    Assay Products for COMMD1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for COMMD1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for COMMD1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for COMMD1 
    Cloud-Clone Corp. CLIAs for COMMD1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR017920 COMM
     IPR009886 HCaRG

    Graphical View of Domain Structure for InterPro Entry Q8N668

    ProtoNet protein and cluster: Q8N668

    1 Blocks protein domain: IPB009886 HCaRG

    UniProtKB/Swiss-Prot: COMD1_HUMAN, Q8N668
    Similarity: Contains 1 COMM domain


    COMMD1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COMD1_HUMAN, Q8N668
    Function: Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation.
    Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays
    a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper
    excretion within hepatocytes

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005507copper ion binding IDA17309234
    GO:0005515protein binding IPI14645214
    GO:0042802identical protein binding IPI15799966
    GO:0042803protein homodimerization activity IPI15799966
         
    COMMD1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for COMMD1:
     Decreased viability with pacli 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Commd1):
     cardiovascular system  embryogenesis  growth/size  homeostasis/metabolism  liver/biliary system 
     mortality/aging  nervous system 

    COMMD1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Commd1tm1Bvds for COMMD1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for COMMD1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for COMMD1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for COMMD1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for COMMD1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COMMD1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate COMMD1
    SwitchGear 3'UTR luciferase reporter plasmidCOMMD1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for COMMD1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COMMD1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for COMMD1
    Sirion Biotech Customized adenovirus for overexpression of COMMD1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for COMMD1 (see all 7)
    OriGene ORF clones in mouse, rat for COMMD1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: COMMD1 (NM_016144)
    Sino Biological Human cDNA Clone for COMMD1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COMMD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COMMD1
    Sirion Biotech Customized lentivirus for stable overexpression of COMMD1 
                         Customized lentivirus expression plasmids for stable overexpression of COMMD1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for COMMD1
    Search LifeMap BioReagents cell lines for COMMD1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COMMD1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for COMMD1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)
    Regulation of CFTR activity (norm and CF)0.38
    wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)0.38
    2Clathrin-dependent protein traffic
    wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)0.37
    3TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 GeneGo (Thomson Reuters) Pathways for COMMD1
        wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
    Regulation of CFTR activity (norm and CF)
    wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)

    1 BioSystems Pathway for COMMD1
        TNF-alpha/NF-kB Signaling Pathway



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for COMMD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/47 Interacting proteins for COMMD1 (Q8N6681, 2, 3 ENSP000003082364) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CUL2Q136172, 3, ENSP000003638804MINT-4140802 MINT-4140816 MINT-4140831 I2D: score=3 STRING: ENSP00000363880
    SCNN1DP511721, 3, ENSP000003215944EBI-1550112,EBI-2547114 I2D: score=2 STRING: ENSP00000321594
    RELBQ012011, 3, ENSP000002214524EBI-1550112,EBI-357837 I2D: score=1 STRING: ENSP00000221452
    SOCS1O155242, 3, ENSP000003294184MINT-4140906 MINT-4140761 MINT-4140776 I2D: score=3 STRING: ENSP00000329418
    RELAQ042061, 3, ENSP000003842734EBI-1550112,EBI-73886 I2D: score=5 STRING: ENSP00000384273
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031398positive regulation of protein ubiquitination IDA17183367
    GO:0032088negative regulation of NF-kappaB transcription factor activity IMP17183367
    GO:0032434regulation of proteasomal ubiquitin-dependent protein catabolic process IMP17183367
    GO:0055070copper ion homeostasis IDA14685266

    COMMD1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    COMMD1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for COMMD1 (COMD1)

    1 HMDB Compound for COMMD1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CopperCu (see all 2)7440-50-8--

    1 Novoseek inferred chemical compound relationship for COMMD1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    copper 71.4 52 17309234 (6), 16868807 (4), 15205742 (3), 14568250 (3) (see all 13)

    Search CenterWatch for drugs/clinical trials and news about COMMD1 / COMD1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for COMMD1 gene: 
    NM_152516.2  

    Unigene Cluster for COMMD1:

    Copper metabolism (Murr1) domain containing 1
    Hs.468702  [show with all ESTs]
    Unigene Representative Sequence: BG481459
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000472729 ENST00000445644 ENST00000471704 ENST00000311832(uc002sbp.3)
    ENST00000455659 ENST00000458337 ENST00000427417 ENST00000444166 ENST00000538736

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COMMD1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate COMMD1
    SwitchGear 3'UTR luciferase reporter plasmidCOMMD1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for COMMD1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COMMD1
    Clone
    Products:
         
    OriGene clones in human, mouse for COMMD1 (see all 7)
    OriGene ORF clones in mouse, rat for COMMD1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: COMMD1 (NM_016144)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COMMD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COMMD1
    Sirion Biotech Customized lentivirus for stable overexpression of COMMD1 
                         Customized lentivirus expression plasmids for stable overexpression of COMMD1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for COMMD1
    OriGene qSTAR qPCR primer pairs in human, mouse for COMMD1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat COMMD1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COMMD1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COMMD1

    Additional mRNA sequence: 

    AB178811.1 AK223607.1 AK294203.1 BC009266.2 BC022046.1 D85433.1 

    12 DOTS entries:

    DT.95269398  DT.100837561  DT.121023375  DT.100813212  DT.415557  DT.121023330  DT.121023198  DT.121023392 
    DT.100742402  DT.121023370  DT.121023384  DT.91745499 

    24/177 AceView cDNA sequences (see all 177):

    CA432882 CR603473 BQ631893 D85433 BM702483 BU736794 BM785232 F37087 
    F30945 BF440009 AA400293 BF689598 CD368588 BQ949150 AI271698 AA345612 
    BM669574 BF439101 BM705216 AA730008 BP333994 AA401423 AA935164 AA412516 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for COMMD1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b
    SP1:                              
    SP2:              -               


    ECgene alternative splicing isoforms for COMMD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    COMMD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCCCTCCCC
    COMMD1 Expression
    About this image


    See COMMD1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for COMMD1

    SOURCE GeneReport for Unigene cluster: Hs.468702

    UniProtKB/Swiss-Prot: COMD1_HUMAN, Q8N668
    Tissue specificity: Ubiquitous. Highest expression in the liver, with lower expression in brain, lung, placenta,
    pancreas, small intestine, heart, skeletal muscle, kidney and placenta

        SABiosciences Custom PCR Arrays for COMMD1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for COMMD1
    OriGene qSTAR qPCR primer pairs in human, mouse for COMMD1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat COMMD1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COMMD1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COMMD1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COMMD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for COMMD1 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Commd11 , 5 COMM domain containing 11, 5 85.87(n)1
    86.41(a)1
      11 (14.22 cM)5
    178461  NM_144514.21  NP_653097.21 
     228347445 
    chicken
    (Gallus gallus)
    Aves COMMD11 copper metabolism (Murr1) domain containing 1 72.61(n)
    71.35(a)
      769006  XM_001231775.2  XP_001231776.1 
    lizard
    (Anolis carolinensis)
    Reptilia COMMD16
    copper metabolism (Murr1) domain containing 1
    60(a)
    1 ↔ 1
    1(121455279-121555446)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.109252 Xenopus laevis transcribed sequences 72.53(n)    BJ621252.1 
    zebrafish
    (Danio rerio)
    Actinopterygii commd11 copper metabolism (Murr1) domain containing 1 59.05(n)
    53.14(a)
      692293  NM_001045265.1  NP_001038730.1 


    ENSEMBL Gene Tree for COMMD1 (if available)
    TreeFam Gene Tree for COMMD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for COMMD1 gene
    2 SIMAP similar genes for COMMD1 using alignment to 6 protein entries:     COMD1_HUMAN (see all proteins):
    C2orf5    TGM4

    COMMD1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4115 SNPs in COMMD1 are shown (see all 4115)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs718781591,2
    C--62029474(+) ACAAA-/AT/AT 
    ATATATAT
    ATATA
    1 -- int10--------
    rs1854511121,2
    --62130827(+) GGACTA/GCAGAC 1 -- us2k10--------
    rs1902561771,2
    --62130913(+) CTCAGA/GTGATC 1 -- us2k10--------
    rs1827588801,2
    --62130916(+) AGGTGA/TTCCAC 1 -- us2k10--------
    rs728917401,2
    C--62130922(+) TCCACC/TCACCT 1 -- us2k10--------
    rs134150471,2
    C--62131381(+) gacctC/Tgtgat 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs1876896881,2
    --62131389(+) GATCCA/GTCTGC 1 -- us2k10--------
    rs1497572031,2
    --62131436(+) CCACCA/GTGCCC 1 -- us2k10--------
    rs1144773261,2
    F--62131441(+) GTGCCC/TGGCAA 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1153679971,2
    F--62131482(+) ATACAG/AAATAT 1 -- us2k11Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for COMMD1 (62115859 - 62365859 bp, first 250kb of COMMD1)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for COMMD1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2665284CNV Deletion23128226
    esv2670023CNV Deletion23128226
    esv267460CNV Insertion20981092
    esv34000CNV Loss18971310
    nsv519398CNV Loss19592680
    nsv458074CNV Gain19166990
    nsv470467CNV Gain18288195
    nsv874231CNV Gain21882294
    nsv874229CNV Gain21882294
    nsv7313OTHER Inversion18451855


    Human Gene Mutation Database (HGMD): COMMD1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing COMMD1
    DNA2.0 Custom Variant and Variant Library Synthesis for COMMD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607238    OMIM disorders: --

    5 diseases for COMMD1:    About MalaCards
    wilson disease    menkes disease    prostate cancer    prostatitis
    hepatitis

    1 disease from the University of Copenhagen DISEASES database for COMMD1:
    Wilson disease

    COMMD1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for COMMD1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wilson disease 83.9 16 15205742 (4), 16610028 (4), 16868807 (3), 16649058 (1) (see all 6)
    cirrhosis 25.7 1 16649058 (1)

    Genetic Association Database (GAD): COMMD1
    Human Genome Epidemiology (HuGE) Navigator: COMMD1 (3 documents)

    Export disorders for COMMD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for COMMD1 gene, integrated from 9 sources (see all 63):
    (articles sorted by number of sources associating them with COMMD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a new copper metabolism gene by positional cloning in a purebred dog population. (PubMed id 11809725)1, 2, 3, 9 van De Sluis B.A.J....Wijmenga C. (2002)
    2. Characterization and copper binding properties of human COMMD1 (MURR1). (PubMed id 17309234)1, 2, 9 Narindrasorasak S....Sarkar B. (2007)
    3. Analysis of the human homologue of the canine copper toxicosis gene MURR1 in Wilson disease patients. (PubMed id 15205742)1, 2, 9 Stuehler B.... Schaefer M. (2004)
    4. Mutation analysis of 218 Chinese patients with Wilson disease revealed no correlation between the canine copper toxicosis gene MURR1 and Wilson disease. (PubMed id 16649058)1, 4, 9 Wu Z.Y....Yu L. (2006)
    5. The canine copper toxicosis gene MURR1 does not cause non-Wilsonian hepatic copper toxicosis. (PubMed id 12547404)1, 2, 9 Mueller T.... Wijmenga C. (2003)
    6. The copper toxicosis gene product Murr1 directly interacts with the Wilson disease protein. (PubMed id 12968035)1, 2, 9 Tao T.Y.... Gitlin J.D. (2003)
    7. Clusterin facilitates COMMD1 and I-kappaB degradation to enhance NF-kappaB activity in prostate cancer cells. (PubMed id 20068069)1, 2 Zoubeidi A....Gleave M.E. (2010)
    8. Cu,Zn superoxide dismutase maturation and activity ar e regulated by COMMD1. (PubMed id 20595380)1, 2 Vonk W.I....Klomp L.W. (2010)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    10. Nucleolar targeting of RelA(p65) is regulated by COMM D1-dependent ubiquitination. (PubMed id 20048074)1, 2 Thoms H.C....Stark L.A. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 150684 HGNC: 23024 AceView: COMMD1 Ensembl:ENSG00000173163 euGenes: HUgn150684
    ECgene: COMMD1 H-InvDB: COMMD1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for COMMD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for COMMD1 gene:
    Search GeneIP for patents involving COMMD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for COMMD1 (COMMD1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for COMMD1   OriGene RNAi products in human, mouse, rat for COMMD1  
     OriGene qPCR primer pairs and template standards for COMMD1   OriGene Protein Over-expression Lysate for COMMD1  
     OriGene MassSpec something-or-other for COMMD1   OriGene clones in human, mouse for COMMD1  
     OriGene qSTAR qPCR primer pairs in human, mouse for COMMD1   OriGene Purified Protein for COMMD1  
     OriGene ORF clones in mouse, rat for COMMD1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for COMMD1   OriGene Custom Protein Services for COMMD1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat COMMD1
     QIAGEN SeqTarget long-range PCR primers for resequencing COMMD1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COMMD1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COMMD1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COMMD1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COMMD1
     GenScript Custom Purified and Recombinant Proteins Services for COMMD1 GenScript cDNA clones with any tag delivered in your preferred vector for COMMD1
     GenScript Custom Assay Services for COMMD1 GenScript Custom Superior Antibodies Services for COMMD1
     GenScript Custom overexpressing Cell Line Services for COMMD1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in COMMD1 promoter
     Search Chromatin IP Primers for COMMD1
     RT2 qPCR Primer Assay in human, mouse, rat COMMD1
     GNC Network for COMMD1
     SABiosciences Custom PCR Arrays for COMMD1
     Search Tocris compounds for COMMD1 (COMD1)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for COMMD1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     COMMD1 antibodies
     COMMD1 proteins
     COMMD1 lysates
     Antibodies for COMMD1
     See all of Abcam's Antibodies, Kits and Proteins for COMMD1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for COMMD1




     Proteins for COMMD1
     Antibodies for COMMD1
     ELISAs for COMMD1
     CLIAs for COMMD1
     Search LifeMap BioReagents cell lines for COMMD1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COMMD1
     SwitchGear 3'UTR luciferase reporter plasmids for COMMD1
     SwitchGear Promoter luciferase reporter plasmids for COMMD1
     Search ThermoFisher Antibodies for COMMD1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COMMD1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for COMMD1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for COMMD1
    Customized:
     lentivirus for stable overexpression of COMMD1
     lentivirus expression plasmids for stable overexpression of COMMD1
     adenovirus for overexpression of COMMD1
     LSBio Antibodies in human, mouse, rat for COMMD1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      COMMD1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4