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Aliases for COLGALT2 Gene

Aliases for COLGALT2 Gene

  • Collagen Beta(1-O)Galactosyltransferase 2 2 3 4
  • Glycosyltransferase 25 Domain Containing 2 2 3
  • Glycosyltransferase 25 Family Member 2 3 4
  • Hydroxylysine Galactosyltransferase 2 3 4
  • C1orf17 3 4
  • GLT25D2 3 4
  • Procollagen Galactosyltransferase 2 3
  • Chromosome 1 Open Reading Frame 17 2
  • EC 2.4.1.50 4
  • KIAA0584 4

External Ids for COLGALT2 Gene

Previous HGNC Symbols for COLGALT2 Gene

  • C1orf17
  • GLT25D2

Summaries for COLGALT2 Gene

GeneCards Summary for COLGALT2 Gene

COLGALT2 (Collagen Beta(1-O)Galactosyltransferase 2) is a Protein Coding gene. Among its related pathways are Degradation of the extracellular matrix and Other types of O-glycan biosynthesis. GO annotations related to this gene include procollagen galactosyltransferase activity. An important paralog of this gene is COLGALT1.

UniProtKB/Swiss-Prot for COLGALT2 Gene

  • Has a beta-galactosyltransferase activity; transfers beta-galactose to hydroxylysine residues on collagen.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COLGALT2 Gene

Genomics for COLGALT2 Gene

Genomic Location for COLGALT2 Gene

Start:
183,929,854 bp from pter
End:
184,037,770 bp from pter
Size:
107,917 bases
Orientation:
Minus strand

Genomic View for COLGALT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COLGALT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COLGALT2 Gene

No data available for Regulatory Elements for COLGALT2 Gene

Proteins for COLGALT2 Gene

  • Protein details for COLGALT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYK4-GT252_HUMAN
    Recommended name:
    Procollagen galactosyltransferase 2
    Protein Accession:
    Q8IYK4
    Secondary Accessions:
    • O60327
    • Q9BZR0

    Protein attributes for COLGALT2 Gene

    Size:
    626 amino acids
    Molecular mass:
    72924 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA25510.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for COLGALT2 Gene

Proteomics data for COLGALT2 Gene at MOPED

Post-translational modifications for COLGALT2 Gene

  • Glycosylation at Asn97, Asn185, Asn382, and Asn580
  • Modification sites at PhosphoSitePlus

Other Protein References for COLGALT2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for COLGALT2 Gene

Domains for COLGALT2 Gene

Protein Domains for COLGALT2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IYK4

UniProtKB/Swiss-Prot:

GT252_HUMAN :
  • Q8IYK4
Family:
  • Belongs to the glycosyltransferase 25 family.
genes like me logo Genes that share domains with COLGALT2: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for COLGALT2 Gene

Function for COLGALT2 Gene

Molecular function for COLGALT2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=33.5 uM for UDP-galactose {ECO:0000269 PubMed:19075007};
UniProtKB/Swiss-Prot CatalyticActivity: UDP-alpha-D-galactose + 5-hydroxy-L-lysine-[procollagen] = UDP + 5-(D-galactosyloxy)-L-lysine-[procollagen].
UniProtKB/Swiss-Prot Function: Has a beta-galactosyltransferase activity; transfers beta-galactose to hydroxylysine residues on collagen.

Enzyme Numbers (IUBMB) for COLGALT2 Gene

Gene Ontology (GO) - Molecular Function for COLGALT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0050211 procollagen galactosyltransferase activity IEA --
genes like me logo Genes that share ontologies with COLGALT2: view

Phenotypes for COLGALT2 Gene

GenomeRNAi human phenotypes for COLGALT2:
genes like me logo Genes that share phenotypes with COLGALT2: view

miRNA for COLGALT2 Gene

miRTarBase miRNAs that target COLGALT2

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for COLGALT2 Gene

Localization for COLGALT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COLGALT2 Gene

Endoplasmic reticulum lumen.

Gene Ontology (GO) - Cellular Components for COLGALT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005788 endoplasmic reticulum lumen TAS --
genes like me logo Genes that share ontologies with COLGALT2: view

No data available for Subcellular locations from COMPARTMENTS for COLGALT2 Gene

Pathways for COLGALT2 Gene

genes like me logo Genes that share pathways with COLGALT2: view

Pathways by source for COLGALT2 Gene

Interacting Proteins for COLGALT2 Gene

Gene Ontology (GO) - Biological Process for COLGALT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009103 lipopolysaccharide biosynthetic process --
GO:0030198 extracellular matrix organization TAS --
genes like me logo Genes that share ontologies with COLGALT2: view

Transcripts for COLGALT2 Gene

Unigene Clusters for COLGALT2 Gene

Collagen beta(1-O)galactosyltransferase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COLGALT2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ·
SP1: - - - - - - - - -
SP2: - - - - - - -
SP3: -
SP4: - - -
SP5: - - -
SP6: -
SP7:
SP8: - -
SP9:

ExUns: 16c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for COLGALT2 Gene

GeneLoc Exon Structure for
COLGALT2
ECgene alternative splicing isoforms for
COLGALT2

Expression for COLGALT2 Gene

mRNA expression in normal human tissues for COLGALT2 Gene

mRNA differential expression in normal tissues according to GTEx for COLGALT2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COLGALT2 Gene

SOURCE GeneReport for Unigene cluster for COLGALT2 Gene Hs.387995

mRNA Expression by UniProt/SwissProt for COLGALT2 Gene

Q8IYK4-GT252_HUMAN
Tissue specificity: Expressed in brain and skeletal muscle.
genes like me logo Genes that share expressions with COLGALT2: view

Orthologs for COLGALT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for COLGALT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GLT25D2 35
  • 99.73 (n)
  • 99.84 (a)
GLT25D2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GLT25D2 35
  • 91.8 (n)
  • 94.09 (a)
GLT25D2 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COLGALT2 35
  • 87.7 (n)
  • 87.08 (a)
COLGALT2 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Colgalt2 35
  • 88.87 (n)
  • 93.06 (a)
Colgalt2 36
  • 92 (a)
OneToOne
Glt25d2 16
oppossum
(Monodelphis domestica)
Mammalia COLGALT2 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COLGALT2 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Colgalt2 35
  • 87.03 (n)
  • 91.39 (a)
chicken
(Gallus gallus)
Aves COLGALT2 36
  • 79 (a)
OneToOne
GLT25D2 35
  • 78.44 (n)
  • 81.26 (a)
lizard
(Anolis carolinensis)
Reptilia COLGALT2 36
  • 83 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12299 35
tropical clawed frog
(Silurana tropicalis)
Amphibia colgalt2 35
  • 72.17 (n)
  • 76 (a)
zebrafish
(Danio rerio)
Actinopterygii colgalt2 35
  • 65.41 (n)
  • 65.01 (a)
colgalt2 36
  • 62 (a)
OneToMany
COLGALT2 (2 of 2) 36
  • 58 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG31915 36
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea D2045.9 36
  • 34 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13713 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToMany
Species with no ortholog for COLGALT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for COLGALT2 Gene

ENSEMBL:
Gene Tree for COLGALT2 (if available)
TreeFam:
Gene Tree for COLGALT2 (if available)

Paralogs for COLGALT2 Gene

Paralogs for COLGALT2 Gene

Selected SIMAP similar genes for COLGALT2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with COLGALT2: view

Variants for COLGALT2 Gene

Sequence variations from dbSNP and Humsavar for COLGALT2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs724426 -- 183,970,792(+) GCAAT(C/T)CATTA intron-variant
rs724427 -- 183,970,851(+) GGATC(A/T)TTTAA intron-variant
rs730601 -- 183,942,468(+) tttac(C/T)ttttt intron-variant
rs734657 -- 183,943,185(-) GCAAT(G/T)GCTCA intron-variant
rs751410 -- 183,992,197(-) TCACC(C/T)CTCTG intron-variant

Relevant External Links for COLGALT2 Gene

HapMap Linkage Disequilibrium report
COLGALT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for COLGALT2 Gene

Disorders for COLGALT2 Gene

No disorders were found for COLGALT2 Gene.

No data available for UniProtKB/Swiss-Prot for COLGALT2 Gene

Publications for COLGALT2 Gene

  1. Core glycosylation of collagen is initiated by two beta(1- O)galactosyltransferases. (PMID: 19075007) Schegg B. … Hennet T. (Mol. Cell. Biol. 2009) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  3. Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus. (PMID: 11318611) Sood R. … Carpten J.D. (Genomics 2001) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for COLGALT2 Gene

Sources for COLGALT2 Gene

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