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Aliases for COLGALT1 Gene

Aliases for COLGALT1 Gene

  • Collagen Beta(1-O)Galactosyltransferase 1 2 3 4
  • Glycosyltransferase 25 Domain Containing 1 2 3
  • Glycosyltransferase 25 Family Member 1 3 4
  • Hydroxylysine Galactosyltransferase 1 3 4
  • GLT25D1 3 4
  • Procollagen Galactosyltransferase 1 3
  • EC 2.4.1.50 4

External Ids for COLGALT1 Gene

Previous HGNC Symbols for COLGALT1 Gene

  • GLT25D1

Previous GeneCards Identifiers for COLGALT1 Gene

  • GC19P017747
  • GC19P017916

Summaries for COLGALT1 Gene

GeneCards Summary for COLGALT1 Gene

COLGALT1 (Collagen Beta(1-O)Galactosyltransferase 1) is a Protein Coding gene. Among its related pathways are Degradation of the extracellular matrix and Other types of O-glycan biosynthesis. GO annotations related to this gene include procollagen galactosyltransferase activity. An important paralog of this gene is PLOD3.

UniProtKB/Swiss-Prot for COLGALT1 Gene

  • Has a beta-galactosyltransferase activity; transfers beta-galactose to hydroxylysine residues of collagen.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COLGALT1 Gene

Genomics for COLGALT1 Gene

Genomic Location for COLGALT1 Gene

Start:
17,555,594 bp from pter
End:
17,583,162 bp from pter
Size:
27,569 bases
Orientation:
Plus strand

Genomic View for COLGALT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COLGALT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COLGALT1 Gene

No data available for Regulatory Elements for COLGALT1 Gene

Proteins for COLGALT1 Gene

  • Protein details for COLGALT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBJ5-GT251_HUMAN
    Recommended name:
    Procollagen galactosyltransferase 1
    Protein Accession:
    Q8NBJ5
    Secondary Accessions:
    • Q8NC64

    Protein attributes for COLGALT1 Gene

    Size:
    622 amino acids
    Molecular mass:
    71636 Da
    Quaternary structure:
    No Data Available

neXtProt entry for COLGALT1 Gene

Proteomics data for COLGALT1 Gene at MOPED

Post-translational modifications for COLGALT1 Gene

Other Protein References for COLGALT1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for COLGALT1 Gene

Domains for COLGALT1 Gene

Protein Domains for COLGALT1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NBJ5

UniProtKB/Swiss-Prot:

GT251_HUMAN :
  • Q8NBJ5
Family:
  • Belongs to the glycosyltransferase 25 family.
genes like me logo Genes that share domains with COLGALT1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for COLGALT1 Gene

Function for COLGALT1 Gene

Molecular function for COLGALT1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=18.7 uM for UDP-galactose {ECO:0000269 PubMed:19075007};
UniProtKB/Swiss-Prot CatalyticActivity: UDP-alpha-D-galactose + 5-hydroxy-L-lysine-[procollagen] = UDP + 5-(D-galactosyloxy)-L-lysine-[procollagen].
UniProtKB/Swiss-Prot Function: Has a beta-galactosyltransferase activity; transfers beta-galactose to hydroxylysine residues of collagen.

Enzyme Numbers (IUBMB) for COLGALT1 Gene

Gene Ontology (GO) - Molecular Function for COLGALT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050211 procollagen galactosyltransferase activity IEA --
genes like me logo Genes that share ontologies with COLGALT1: view

Phenotypes for COLGALT1 Gene

GenomeRNAi human phenotypes for COLGALT1:
genes like me logo Genes that share phenotypes with COLGALT1: view

Animal Model Products

CRISPR Products

miRNA for COLGALT1 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for COLGALT1 Gene

Localization for COLGALT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COLGALT1 Gene

Endoplasmic reticulum lumen. Note=Colocalized with PLOD3 and mannose binding lectin.

Gene Ontology (GO) - Cellular Components for COLGALT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with COLGALT1: view

No data available for Subcellular locations from COMPARTMENTS for COLGALT1 Gene

Pathways for COLGALT1 Gene

genes like me logo Genes that share pathways with COLGALT1: view

Pathways by source for COLGALT1 Gene

Interacting Proteins for COLGALT1 Gene

Gene Ontology (GO) - Biological Process for COLGALT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009103 lipopolysaccharide biosynthetic process --
GO:0030198 extracellular matrix organization TAS --
genes like me logo Genes that share ontologies with COLGALT1: view

Transcripts for COLGALT1 Gene

Unigene Clusters for COLGALT1 Gene

Collagen beta(1-O)galactosyltransferase 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COLGALT1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COLGALT1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d · 13e ^ 14a · 14b
SP1: - - - - -
SP2: - -
SP3: - - - - -
SP4: -
SP5:
SP6:

Relevant External Links for COLGALT1 Gene

GeneLoc Exon Structure for
COLGALT1
ECgene alternative splicing isoforms for
COLGALT1

Expression for COLGALT1 Gene

mRNA expression in normal human tissues for COLGALT1 Gene

mRNA differential expression in normal tissues according to GTEx for COLGALT1 Gene

This gene is overexpressed in Whole Blood (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COLGALT1 Gene

SOURCE GeneReport for Unigene cluster for COLGALT1 Gene Hs.418795

mRNA Expression by UniProt/SwissProt for COLGALT1 Gene

Q8NBJ5-GT251_HUMAN
Tissue specificity: Ubiquitous with higher levels in placenta, heart, lung and spleen.
genes like me logo Genes that share expressions with COLGALT1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for COLGALT1 Gene

Orthologs for COLGALT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for COLGALT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GLT25D1 35
  • 98.79 (n)
  • 99.15 (a)
GLT25D1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia COLGALT1 35
  • 89.66 (n)
  • 94.37 (a)
COLGALT1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COLGALT1 35
  • 90.73 (n)
  • 97.61 (a)
COLGALT1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Colgalt1 36
  • 92 (a)
OneToOne
Glt25d1 35
  • 86.79 (n)
  • 93.71 (a)
Glt25d1 16
oppossum
(Monodelphis domestica)
Mammalia COLGALT1 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COLGALT1 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Colgalt1 35
  • 86.05 (n)
  • 93.88 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 84 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia COLGALT1 36
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13613 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488616 35
  • 69.34 (n)
  • 69.28 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4024 35
zebrafish
(Danio rerio)
Actinopterygii colgalt1 35
  • 68.37 (n)
  • 72.74 (a)
colgalt1 36
  • 69 (a)
OneToMany
COLGALT1 (1 of 3) 36
  • 73 (a)
OneToMany
COLGALT1 (3 of 3) 36
  • 75 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG31915 36
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea D2045.9 36
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToMany
Species with no ortholog for COLGALT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for COLGALT1 Gene

ENSEMBL:
Gene Tree for COLGALT1 (if available)
TreeFam:
Gene Tree for COLGALT1 (if available)

Paralogs for COLGALT1 Gene

Paralogs for COLGALT1 Gene

Selected SIMAP similar genes for COLGALT1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with COLGALT1: view

Variants for COLGALT1 Gene

Sequence variations from dbSNP and Humsavar for COLGALT1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs8090 -- 17,582,871(+) CTCCC(A/C/G/T)GTCCC utr-variant-3-prime
rs891184 -- 17,580,942(+) TTTCA(C/T)GGTGG intron-variant
rs2082001 -- 17,557,644(+) tcgcc(C/T)aggcg intron-variant
rs2115492 -- 17,578,005(+) CTGCC(G/T)GGCTA synonymous-codon, reference
rs2303799 -- 17,582,397(+) CTTTT(C/T)ACTTT utr-variant-3-prime

Relevant External Links for COLGALT1 Gene

HapMap Linkage Disequilibrium report
COLGALT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for COLGALT1 Gene

Disorders for COLGALT1 Gene

No disorders were found for COLGALT1 Gene.

No data available for UniProtKB/Swiss-Prot for COLGALT1 Gene

Publications for COLGALT1 Gene

  1. Core glycosylation of collagen is initiated by two beta(1- O)galactosyltransferases. (PMID: 19075007) Schegg B. … Hennet T. (Mol. Cell. Biol. 2009) 2 3 4
  2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4
  3. The human collagen beta(1-O)galactosyltransferase, GLT25D1, is a soluble endoplasmic reticulum localized protein. (PMID: 20470363) Liefhebber J.M. … van Leeuwen H.C. (BMC Cell Biol. 2010) 3 4
  4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  5. Purification and identification of endogenous polySUMO conjugates. (PMID: 21252943) Bruderer R. … Hay R.T. (EMBO Rep. 2011) 3

Products for COLGALT1 Gene

  • antibodies-online proteins for COLGALT1
  • antibodies-online antibodies for COLGALT1
  • antibodies-online kits for COLGALT1

Sources for COLGALT1 Gene

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