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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

COLEC12 Gene

protein-coding   GIFtS: 53
GCID: GC18M000309

collectin sub-family member 12
 Explore 10 diseases affiliated with
COLEC12 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for COLEC12    

Aliases
for COLEC12 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Collectin Sub-Family Member 121 2     Scavenger Receptor With C-Type Lectin2 3
SRCL1 2 3 5     NSR22 3
SCARA41 2 3     HCL-P11
CLP12 3 5     Collectin-121
CL-P11 3     Scavenger Receptor Class A, Member 42
Collectin Placenta Protein 12 3     Scavenger Receptor Class A Member 43
Nurse Cell Scavenger Receptor 22 3     

External Ids:    HGNC: 160161   Entrez Gene: 810352   Ensembl: ENSG000001582707   OMIM: 6076215   UniProtKB: Q5KU263   

Export aliases for COLEC12 gene to outside databases

Previous GC identifers: GC18M000603 GC18M000306


Summaries
for COLEC12 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for COLEC12:
This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate
recognition domains. This protein is a scavenger receptor, a cell surface glycoprotein that displays several functions
associated with host defense. It can bind to carbohydrate antigens on microorganisms, facilitating their recognition
and removal. It also mediates the recognition, internalization, and degradation of oxidatively modified low density
lipoprotein by vascular endothelial cells. (provided by RefSeq, Oct 2011)

UniProtKB/Swiss-Prot: COL12_HUMAN, Q5KU26
Function: Scavenger receptor that displays several functions associated with host defense. Promotes binding and
phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and
degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several
carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a
calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a
trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid beta in Alzheimer
disease




Genomic Views
for COLEC12 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.1  NT_010859.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the COLEC12 gene promoter:
         HFH-3   SRF   AML1a   SRF (504 AA)   IRF-1   FOXI1   Nkx6-1   FOXO4   HFH-1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: COLEC12 promoter sequence
   Search SABiosciences Chromatin IP Primers for COLEC12

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COLEC12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18pter-p11.3   Ensembl cytogenetic band:  18p11.32   HGNC cytogenetic band: 18pter-p11.3

COLEC12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COLEC12 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M000309:  view genomic region     (about GC identifiers)

Start:
 319,355 bp from pter      End:
 500,729 bp from pter
Size:
 181,375 bases      Orientation:
 minus strand

Proteins
for COLEC12 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: COL12_HUMAN, Q5KU26 (See protein sequence)
Recommended Name: Collectin-12  
Size: 742 amino acids; 81515 Da
Subunit: The extracellular domain forms a stable trimer. The extracellular domain interacts with fibrillar beta amyloid
peptide
Subcellular location: Membrane; Single-pass type II membrane protein. Note=Forms clusters on the cell surface
Sequence caution: Sequence=BAB39148.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
1 PDB 3D structure from and Proteopedia for COLEC12:
2OX8 (3D)    
Secondary accessions: Q6P9F2 Q8TCR2 Q8WZA4 Q9BY85 Q9BYH7

Explore the universe of human proteins at neXtProt for COLEC12: NX_Q5KU26

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q5KU26

    • COLEC12 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_569057.1  
    ENSEMBL proteins: 
     ENSP00000383115  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for COLEC12 (CL-P1/COLEC12)
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    OriGene Purified Protein: COLEC12
    OriGene Protein Over-expression Lysate: COLEC12
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    Novus Biologicals COLEC12 Proteins
    Novus Biologicals COLEC12 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for COLEC12

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005581collagen IEA--
    GO:0016021integral to membrane TAS11162630


    COLEC12 for ontologies           About GeneDecksing



    COLEC12 Antibody Products: 
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    Uscn ELISAs and CLIAs for COLEC12

    Protein Domains /
    Families
    for COLEC12 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    COLEC12 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR016187 C-type_lectin_fold
     IPR018378 C-type_lectin_CS
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin
     IPR008160 Collagen

    Graphical View of Domain Structure for InterPro Entry Q5KU26

    ProtoNet protein and cluster: Q5KU26

    2 Blocks protein families:
    IPB002353 Type II antifreeze protein signature
    IPB008160 Collagen triple helix repeat


    UniProtKB/Swiss-Prot: COL12_HUMAN, Q5KU26
    Similarity: Contains 1 C-type lectin domain
    Similarity: Contains 3 collagen-like domains


    Function
    for COLEC12 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: COL12_HUMAN, Q5KU26
    Function: Scavenger receptor that displays several functions associated with host defense. Promotes binding and
    phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and
    degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several
    carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a
    calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a
    trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid beta in Alzheimer
    disease

    miRNA
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate COLEC12:
    hsa-miR-3685 hsa-miR-1290 hsa-miR-9 hsa-let-7g* hsa-miR-493* hsa-miR-155* hsa-let-7a-2*
    SwitchGear 3'UTR luciferase reporter plasmid: COLEC12 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: COLEC12
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    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COLEC12 (see all 3)
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    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005044scavenger receptor activity TAS11162630
    GO:0005534galactose binding NAS11564734
    GO:0008329pattern recognition receptor activity IDA11564734
    GO:0030169low-density lipoprotein particle binding IDA11564734
    GO:0046872metal ion binding IEA--


    COLEC12 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for COLEC12:
     Increased G1 DNA content  Proliferating cells 

    Animal Models:
         1 MGI phenotypic allele for Colec12 (no phenotypes)

    COLEC12 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for COLEC12 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Phagosome
    		Phagosome1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for COLEC12):
        Phagosome


    COLEC12 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for COLEC12

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for COLEC12 (Q5KU263 ENSP000003831154) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EXOC1Q9NV703, ENSP000003265144I2D: score=2 STRING: ENSP00000326514
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002221pattern recognition receptor signaling pathway IDA11564734
    GO:0006910phagocytosis, recognition IDA11564734
    GO:0006952defense response TAS11162630
    GO:0006955immune response ----
    GO:0009756carbohydrate mediated signaling NAS11564734


    COLEC12 for ontologies           About GeneDecksing



    Drugs & Compounds
    for COLEC12 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    COLEC12 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for COLEC12

    3 HMDB Compounds for COLEC12    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    D-Galactose(+)-Galactose (see all 14)59-23-4--
    Lewis X trisaccharide3-Fucosyl-N-acetyllactosamine (see all 8)71208-06-5--
    2 Novoseek chemical compound relationships for COLEC12 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    galactose 41.3 2 16670103 (1), 15845541 (1)
    polysaccharide 39.6 4 16670103 (1), 17420244 (1), 15845541 (1)

    Search CenterWatch for drugs/clinical trials and news about COLEC12 / COL12 

    Transcripts
    for COLEC12 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for COLEC12 gene (2 alternative transcripts): 
    NM_130386.2  NM_030781.2  

    Unigene Cluster for COLEC12:

    Collectin sub-family member 12
    Hs.464422  [show with all ESTs]
    Unigene Representative Sequence: NM_130386
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000400256(uc002kkm.3) ENST00000582147

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COLEC12
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate COLEC12:
    hsa-miR-3685 hsa-miR-1290 hsa-miR-9 hsa-let-7g* hsa-miR-493* hsa-miR-155* hsa-let-7a-2*
    SwitchGear 3'UTR luciferase reporter plasmid: COLEC12 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COLEC12 (see all 7)
    OriGene shRNA RFP: COLEC12
    OriGene siRNA: COLEC12
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COLEC12
    Clone
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    GenScript: all cDNA clones in your preferred vector: COLEC12 (NM_130386)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COLEC12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COLEC12 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat COLEC12
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COLEC12
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COLEC12

    Additional cDNA sequence: 

    AB005145.1 AB034251.1 AB038518.1 AL713657.1 BC060789.1 

    5 DOTS entries:

    DT.455710  DT.91973502  DT.95310302  DT.97804571  DT.95371373 

    24/106 AceView cDNA sequences (see all 106):

    BQ030255 CR610483 N48549 AA775122 AL541116 AL543001 R74388 CF528303 
    CA392710 BX377133 AW316714 AA723386 AA977789 CD632747 AA304251 BG152599 
    AI968658 BM993196 BQ674807 NM_030781 AA709417 BU624576 CB989155 AI570918 

    GeneLoc Exon Structure


    Expression
    for COLEC12 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    COLEC12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGCCAAAGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    COLEC12 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Extraembryonic MesodermExtraembryonic Capillary PlexusExtraembryonic AngioblastsEndothelium
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    SomiteThoracic Ventrolateral Dermomyotome LipMuscle Progenitor CellsSkeletal Muscle
    BoneEndochondral Facial BonesBone
    BoneStylopod Long BoneBone
    BoneThoracic RibBone
    BoneZeugopod Long BoneBone
    BrainMeningesBrain
    Gut TubeMidgutGut Tube
    LungTracheaLung
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10/17 LifeMap Cells (see all 17) 
    NameCategory
    PureStem™ progenitor T42 (Embryonic Progenitor Cell)
    PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)Endothelium
    PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)Lateral Plate Mesoderm, Neural Crest
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN27 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN7 (Embryonic Progenitor Cell)
    PureStem™ progenitor F15 (Embryonic Progenitor Cell)
    PureStem™ progenitor SM22 (Embryonic Progenitor Cell)

    See COLEC12 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for COLEC12

    SOURCE GeneReport for Unigene cluster: Hs.464422

    UniProtKB/Swiss-Prot: COL12_HUMAN, Q5KU26
    Tissue specificity: Expressed in perivascular macrophages. Expressed in plaques-surrounding reactive astrocytes and in
    perivascular astrocytes associated with cerebral amyloid angiopathy (CAA) in the temporal cortex of Alzheimer patient
    (at protein level). Strongly expressed in placenta. Moderately expressed in heart, skeletal muscle, small intestine
    and lung. Weakly expressed in brain, colon, thymus and kidney. Expressed in nurse-like cells. Expressed in reactive
    astrocytes and vascular/perivascular cells in the brain of Alzheimer patient

        SABiosciences Expression via Pathway-Focused PCR Arrays including COLEC12: 
              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat
              Antifungal Response in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COLEC12

    Orthologs
    for COLEC12 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for COLEC12 gene from 4/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves COLEC121 collectin sub-family member 12 76.01(n)
    81.22(a)    		   421061  NM_001039599.1  NP_001034688.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 63(a)
    		 1 ↔ 1
    		 4(39365487-39374091)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.199552 Xenopus laevis transcribed sequence with strong similarity more 85.81(n)    BQ401058.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii idibd28262 idibd2826 79.13(n)   338130  AI545067.1 


    ENSEMBL Gene Tree for COLEC12 (if available)
    TreeFam Gene Tree for COLEC12 (if available) 

    Paralogs
    for COLEC12 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for COLEC12 gene
    SFTPA12  COLEC112  SFTPD2  MBL22  COLEC102  SCARA32  SFTPA22  
    5 SIMAP similar genes for COLEC12 using alignment to 1 protein entry:     COL12_HUMAN:
    CLEC6A    SCARA3    FCER2    REG1B    REG1A

    COLEC12 for paralogs           About GeneDecksing



    Genomic Variants
    for COLEC12 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3686 NCBI SNPs in COLEC12 are shown (see all 3686)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 18 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1812639351,2
    		--318948(+) TCTGCC/TTTTGG 1 -- ds50010--------
    rs588816841,2
    		C,--318967(+) ACGCC-/ATACGT 1 -- ds50010--------
    rs1855389511,2
    		--319044(+) CAGGGC/TCTTCC 1 -- ds50010--------
    rs124584341,2
    		C,H,--319098(+) TCCCCC/TACACC 1 -- ds50012Minor allele frequency- T:0.03NA EA 122
    rs6757121,2
    		C,F,O,H,--319176(+) CACACG/ATCAAG 1 -- ds500121Minor allele frequency- A:0.42MN NS EA NA WA CSA 2510
    rs1898547771,2
    		--319202(+) TGGGCA/TCAAGG 1 -- ds50010--------
    rs28466111,2
    		C,F,--319272(-) AAATAT/CCCTTG 1 -- ds50015Minor allele frequency- C:0.27NA EA 246
    rs1998772381,2
    		--319364(+) TATAT-/ACACATG 1 -- ut310--------
    rs124584881,2
    		C,F,H--319365(+) ATATAT/CACATG 1 -- ut31 ese33Minor allele frequency- C:0.25NA 8
    rs106601,2
    		C,F,H,--319446(-) CTAGGG/TTTTCC 1 -- ut31 ese323Minor allele frequency- T:0.26MN NS EA NA WA CSA 2566

    HapMap Linkage Disequilibrium report for COLEC12 (319355 - 500729 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for COLEC12: --

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    Disorders / Diseases
    for COLEC12 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    COLEC12 for disorders           About GeneDecksing

    OMIM gene information: 607621    OMIM disorders: --

    10 diseases for COLEC12:    About MalaCards
    cerebral amyloid angiopathy    enamel erosion    hepatitis b    alzheimer's disease
    cerebritis    breast carcinoma    hepatitis    cholesterol
    schizophrenia    carcinoma

    Human Genome Epidemiology (HuGE) Navigator: COLEC12 (2 documents)

    Export disorders for COLEC12 gene to outside databases

    Publications
    for COLEC12 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for COLEC12 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with COLEC12)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and functional characterization of a human scavenger receptor with C-type lectin (SRCL), a novel member of a scavenger receptor family. (PubMed id 11162630)1, 2, 3, 9 Nakamura K.... Nakamura T. (2001)
    2. Haplotype analysis of the human collectin placenta 1 (hCL-P1) gene. (PubMed id 12601552)1, 2, 9 Ohmori H.... Hata A. (2003)
    3. Selective binding of the scavenger receptor C-type lectin to Lewis X trisaccharide and related glycan ligands. (PubMed id 15845541)1, 2, 9 Coombs P.J.... Taylor M.E. (2005)
    4. The membrane-type collectin CL-P1 is a scavenger receptor on vascular endothelial cells. (PubMed id 11564734)1, 2, 9 Ohtani K.... Wakamiya N. (2001)
    5. SRCL/CL-P1 recognizes GalNAc and a carcinoma-associated antigen, Tn antigen. (PubMed id 12761161)1, 2 Yoshida T.... Suzuki R. (2003)
    6. Expression and tissue localization of collectin placenta 1 (CL-P1, SRCL) in human tissues. (PubMed id 18423602)1, 9 Selman L....Hansen S. (2008)
    7. Scavenger receptor collectin placenta 1 (CL-P1) predominantly mediates zymosan phagocytosis by human vascular endothelial cells. (PubMed id 19073604)1, 9 Jang S....Wakamiya N. (2009)
    8. Possible role of scavenger receptor SRCL in the clearance of amyloid- beta in Alzheimer's disease. (PubMed id 16868960)2, 9 Nakamura K.... Nakamura T. (2006)
    9. Scavenger receptor C-type lectin binds to the leukocyte cell surface glycan Lewis X by a novel mechanism. (PubMed id 17420244)2, 9 Feinberg H.... Weis W.I. (2007)
    10. Identification of neutrophil granule glycoproteins as Lewis(x)-containing ligands cleared by the scavenger receptor C-type lectin. (PubMed id 21561871)1 Graham S.A....Taylor M.E. (2011)

    External Searches for COLEC12 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing COLEC12 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 81035 HGNC: 16016 AceView: COLEC12 Ensembl:ENSG00000158270 euGenes: HUgn81035
    ECgene: COLEC12 Kegg: 81035 H-InvDB: COLEC12

    Other Databases showing COLEC12 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing COLEC12 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for COLEC12 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for COLEC12 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for COLEC12 gene:
    Search GeneIP for patents involving COLEC12

    GeneCards and IP:
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