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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

COLEC12 Gene

protein-coding GIFtS: 59
GCID: GC18M000309

Collectin Sub-Family Member 12

Microbiology & Infectious Diseases Congress

9 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Collectin Sub-Family Member 12¹ ²		SCARA4² ³
CLP1² ³ ⁵		hCL-P1² ³
SRCL² ³ ⁵		collectin-12²
Collectin Placenta Protein 1² ³		Scavenger Receptor Class A, Member 4²
Nurse Cell Scavenger Receptor 2² ³		CL-P1³
Scavenger Receptor With C-Type Lectin² ³		Scavenger Receptor Class A Member 4³
NSR2² ³

External Ids:	HGNC: 16016¹	Entrez Gene: 81035²	Ensembl: ENSG00000158270⁷	OMIM: 607621⁵	UniProtKB: Q5KU26³

Export aliases for COLEC12 gene to outside databases

Previous GC identifers: GC18M000603 GC18M000306

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for COLEC12 Gene:

This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate

recognition domains. This protein is a scavenger receptor, a cell surface glycoprotein that displays several functions

associated with host defense. It can bind to carbohydrate antigens on microorganisms, facilitating their recognition

and removal. It also mediates the recognition, internalization, and degradation of oxidatively modified low density

lipoprotein by vascular endothelial cells. (provided by RefSeq, Oct 2011)

GeneCards Summary for COLEC12 Gene:

COLEC12 (collectin sub-family member 12) is a protein-coding gene. Diseases associated with COLEC12 include enamel erosion, and cerebral amyloid angiopathy, and among its related super-pathways are Scavenging of Heme from Plasma. GO annotations related to this gene include scavenger receptor activity and signaling pattern recognition receptor activity. An important paralog of this gene is COL28A1.

UniProtKB/Swiss-Prot: COL12_HUMAN, Q5KU26

Function: Scavenger receptor that displays several functions associated with host defense. Promotes binding and

phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and

degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several

carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a

calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a

trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid beta in Alzheimer

disease

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000018.9 NC_018929.2 NT_010859.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the COLEC12 gene promoter:
HFH-3 SRF AML1a SRF (504 AA) IRF-1 FOXI1 Nkx6-1 FOXO4 HFH-1 FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: COLEC12 promoter sequence

Search SABiosciences Chromatin IP Primers for COLEC12

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COLEC12

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.32 Ensembl cytogenetic band: 18p11.32 HGNC cytogenetic band: 18p11.32

COLEC12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COLEC12 gene location

GeneLoc information about chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18M000309: view genomic region (about GC identifiers)

Start:	319,355 bp from pter	End:	500,729 bp from pter
Size:	181,375 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: COL12_HUMAN, Q5KU26 (See protein sequence)

Recommended Name: Collectin-12

Size: 742 amino acids; 81515 Da

Subunit: The extracellular domain forms a stable trimer. The extracellular domain interacts with fibrillar beta amyloid

peptide

Subcellular location: Membrane; Single-pass type II membrane protein. Note=Forms clusters on the cell surface

Sequence caution: Sequence=BAB39148.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;

1 PDB 3D structure from and Proteopedia for COLEC12:

2OX8 (3D)

Secondary accessions: Q6P9F2 Q8TCR2 Q8WZA4 Q9BY85 Q9BYH7

Explore the universe of human proteins at neXtProt for COLEC12: NX_Q5KU26

Explore proteomics data for COLEC12 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q5KU26

COLEC12 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_569057.1

ENSEMBL proteins:

ENSP00000383115

Reactome Protein details: Q5KU26
Human Recombinant Protein Products for COLEC12:

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	Novus Biologicals COLEC12 Proteins Novus Biologicals COLEC12 Lysates
	Sino Biological Recombinant Protein for COLEC12 Sino Biological Cell Lysate for COLEC12
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005581	collagen	IEA	--
GO:0005886	plasma membrane	TAS	--
GO:0016021	integral to membrane	TAS	11162630
GO:0030666	endocytic vesicle membrane	TAS	--

COLEC12 for ontologies About GeneDecksing

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	LSBio Antibodies in human, mouse, rat for COLEC12

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	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

COLEC: Collectins

5 InterPro protein domains:

IPR016187 C-type_lectin_fold

IPR018378 C-type_lectin_CS

IPR016186 C-type_lectin-like

IPR001304 C-type_lectin

IPR008160 Collagen

Graphical View of Domain Structure for InterPro Entry Q5KU26

ProtoNet protein and cluster: Q5KU26

2 Blocks protein domains:

IPB002353 Type II antifreeze protein signature

IPB008160 Collagen triple helix repeat

UniProtKB/Swiss-Prot: COL12_HUMAN, Q5KU26

Similarity: Contains 1 C-type lectin domain

Similarity: Contains 3 collagen-like domains

COLEC12 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: COL12_HUMAN, Q5KU26

Function: Scavenger receptor that displays several functions associated with host defense. Promotes binding and

phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and

degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several

carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a

calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a

trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid beta in Alzheimer

disease

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005044	scavenger receptor activity	TAS	11162630
GO:0005534	galactose binding	NAS	11564734
GO:0008329	signaling pattern recognition receptor activity	IDA	11564734
GO:0030169	low-density lipoprotein particle binding	IDA	11564734
GO:0030246	carbohydrate binding	--	--

COLEC12 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for COLEC12:

Increased G1 DNA content

Proliferating cells

1 MGI phenotypic allele

for Colec12 (no phenotypes)

COLEC12 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for COLEC12

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for COLEC12

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COLEC12
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate COLEC12:
		hsa-miR-3685 hsa-miR-1290 hsa-miR-9 hsa-let-7g* hsa-miR-493* hsa-miR-155* hsa-let-7a-2*
		SwitchGear 3'UTR luciferase reporter plasmid: COLEC12 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for COLEC12
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		Sirion Biotech Custom design and validation of potent shRNA sequences against COLEC12

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for COLEC12
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for COLEC12 (see all 7) OriGene ORF clones in mouse, rat for COLEC12 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: COLEC12 (NM_130386)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for COLEC12
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COLEC12

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for COLEC12
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COLEC12

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for COLEC12 About

See pathways by source

SuperPath

Contained pathways About

Binding and Uptake of Ligands by Scavenger Receptors

Binding and Uptake of Ligands by Scavenger Receptors

0.63

Scavenging by Class A Receptors

Scavenging by Class A Receptors

Phagosome

Phagosome

Pathways by source See SuperPaths
Show all pathways

2 Reactome Pathways for COLEC12

	Scavenging by Class A Receptors
	Binding and Uptake of Ligands by Scavenger Receptors

1 Kegg Pathway (Kegg details for COLEC12):

Phagosome

COLEC12 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for COLEC12

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for COLEC12 (Q5KU26³ ENSP00000383115⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EXOC1	Q9NV70³, ENSP00000326514⁴	I2D: score=2 STRING: ENSP00000326514

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002221	pattern recognition receptor signaling pathway	IDA	11564734
GO:0006910	phagocytosis, recognition	IDA	11564734
GO:0006952	defense response	TAS	11162630
GO:0006955	immune response	--	--
GO:0009756	carbohydrate mediated signaling	NAS	11564734

COLEC12 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

COLEC12 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for COLEC12 (COL12)

3 HMDB Compounds for COLEC12 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
D-Galactose	(+)-Galactose (see all 14)	59-23-4	--
Lewis X trisaccharide	3-Fucosyl-N-acetyllactosamine (see all 8)	71208-06-5	--

2 Novoseek inferred chemical compound relationships for COLEC12 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
galactose	41.3	2	16670103 (1), 15845541 (1)
polysaccharide	39.6	4	16670103 (1), 17420244 (1), 15845541 (1)

Search CenterWatch for drugs/clinical trials and news about COLEC12 / COL12

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for COLEC12 gene (2 alternative transcripts):

NM_130386.2 NM_030781.2

Unigene Cluster for COLEC12:

Collectin sub-family member 12

Hs.464422 [show with all ESTs]

Unigene Representative Sequence: NM_130386

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000400256(uc002kkm.3) ENST00000582147

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COLEC12
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate COLEC12:
		hsa-miR-3685 hsa-miR-1290 hsa-miR-9 hsa-let-7g* hsa-miR-493* hsa-miR-155* hsa-let-7a-2*
		SwitchGear 3'UTR luciferase reporter plasmid: COLEC12 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for COLEC12
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		Sirion Biotech Custom design and validation of potent shRNA sequences against COLEC12

Clone Products:		OriGene clones in human, mouse for COLEC12 (see all 7) OriGene ORF clones in mouse, rat for COLEC12 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: COLEC12 (NM_130386)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for COLEC12
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COLEC12

Primer Products:		OriGene qPCR primer pairs and template standards for COLEC12 OriGene qSTAR qPCR primer pairs in human, mouse for COLEC12
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat COLEC12
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COLEC12
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COLEC12

Additional mRNA sequence:

AB005145.1 AB034251.1 AB038518.1 AL713657.1 BC060789.1

5 DOTS entries:

DT.455710 DT.91973502 DT.95310302 DT.97804571 DT.95371373

24/106 AceView cDNA sequences (see all 106):

R74388 AL541116 AA775122 AL543001 CF528303 N48549 CA392710 BQ030255

BX377133 CR610483 BM721855 AI368731 CD632747 AI968658 BM993196 BQ017398

AA304251 BG152599 CB989155 NM_130386 AW771730 AW316714 BU624773 AI923805

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

COLEC12 expression in normal human tissues (normalized intensities) COLEC12 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GAGCCAAAGA

About this image

COLEC12 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/21 selected tissues (see all 21) fully expand


Bone (Muscoskeletal System) fully expand to see all 15 entries
Zeugopod Long Bone
"PureStem 4D20.8, NCr-fac Progenitor"
skeleton/pectoral girdle and thoracic body wall/sternum

Cartilage (Muscoskeletal System) fully expand to see all 8 entries
"PureStem SM30, NCr-fac & Meso-latp Progenitor"
sensory organ/ear/inner ear

Neural Crest (Gastrulation Derivatives) fully expand to see all 6 entries
"PureStem 4D20.8, NCr-fac Progenitor"
skeleton/cranium/chondrocranium

Mesoderm (Gastrulation Derivatives) fully expand to see all 4 entries
DKK1-induced cells (Derivation of cardiomyocytes from induced pluripotent stem (iPS)...
mesenchyme

Lung (Respiratory System) fully expand to see all 3 entries
Trachea
visceral organ/lung/right lung

See COLEC12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for COLEC12

SOURCE GeneReport for Unigene cluster: Hs.464422

UniProtKB/Swiss-Prot: COL12_HUMAN, Q5KU26

Tissue specificity: Expressed in perivascular macrophages. Expressed in plaques-surrounding reactive astrocytes and in

perivascular astrocytes associated with cerebral amyloid angiopathy (CAA) in the temporal cortex of Alzheimer patient

(at protein level). Strongly expressed in placenta. Moderately expressed in heart, skeletal muscle, small intestine

and lung. Weakly expressed in brain, colon, thymus and kidney. Expressed in nurse-like cells. Expressed in reactive

astrocytes and vascular/perivascular cells in the brain of Alzheimer patient

SABiosciences Expression via Pathway-Focused PCR Arrays including COLEC12:

Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

Antifungal Response in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for COLEC12 OriGene qSTAR qPCR primer pairs in human, mouse for COLEC12
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat COLEC12
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COLEC12

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COLEC12

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for COLEC12 gene from 5/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Colec12^{1 , 5}	collectin sub-family member 12^{1, 5}	87.69(n)¹ 92.45(a)¹		18 (4.91 cM)⁵ 140792¹ NM_130449.2¹ NP_569716.2¹ 9707648⁵
chicken (Gallus gallus)	Aves	COLEC12¹	collectin sub-family member 12	76.01(n) 81.22(a)		421061 NM_001039599.1 NP_001034688.1
lizard (Anolis carolinensis)	Reptilia	COLEC12⁶	collectin sub-family member 12	76(a)	1 ↔ 1	4(39363120-39459939)
African clawed frog (Xenopus laevis)	Amphibia	Xl.19955²	Xenopus laevis transcribed sequence with strong similarity more	85.81(n)		BQ401058.1
zebrafish (Danio rerio)	Actinopterygii	idibd2826²	idibd2826	79.13(n)		338130 AI545067.1

ENSEMBL Gene Tree for COLEC12 (if available)
TreeFam Gene Tree for COLEC12 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for COLEC12 gene

COL28A1² COL6A1² COL6A5² COLQ² COL6A6² COL6A2² SCARA3² COL17A1²

COL6A3²

5 SIMAP similar genes for COLEC12 using alignment to 1 protein entry: COL12_HUMAN:

CLEC6A SCARA3 FCER2 REG1B REG1A

COLEC12 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 18 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
VAR_038855⁴		--	--	see VAR_038855	2	S P	mis⁴		0	--	--	--	--
rs181263935^1,2		--	309083(+)	`TCTGCC/TTTTGG`	1	--	ds500¹		0	--	--	--	--
rs58881684^1,2	C	--	309102(+)	`ACGCC-/ATACGT`	1	--	ds500¹		0	--	--	--	--
rs185538951^1,2		--	309179(+)	`CAGGGC/TCTTCC`	1	--	ds500¹		0	--	--	--	--
rs12458434^1,2	C,H	--	309233(+)	`TCCCCC/TACACC`	1	--	ds500¹		2		NA EA	122
rs675712^1,2	C,F,O,H	--	309311(+)	`CACACG/ATCAAG`	1	--	ds500¹		21		MN NS EA NA WA CSA	2510
rs189854777^1,2		--	309337(+)	`TGGGCA/TCAAGG`	1	--	ds500¹		0	--	--	--	--
rs2846611^1,2	C,F	--	309407(-)	`AAATAT/CCCTTG`	1	--	ds500¹		5		NA EA	246
rs199877238^1,2		--	309499(+)	`TATAT-/ACACATG`	1	--	ut3¹		0	--	--	--	--
rs12458488^1,2	C,F,H	--	309500(+)	`ATATAT/CACATG`	1	--	ut3¹ ese³		3		NA	8

HapMap Linkage Disequilibrium report for COLEC12 (319355 - 500729 bp)

Structural Variations
Database of Genomic Variants (DGV) 10/11 variations for COLEC12 (see all 11): About this table

Variant ID	Type	Subtype	PubMed ID
nsv2177	CNV	Insertion	18451855
nsv517980	CNV	Loss	19592680
nsv510444	CNV	Loss	20534489
nsv909290	CNV	Loss	21882294
nsv909289	CNV	Loss	21882294
nsv522804	CNV	Loss	19592680
nsv909288	CNV	Loss	21882294
nsv909291	CNV	Gain	21882294
nsv518642	CNV	Gain	19592680
nsv909287	CNV	Gain	21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

COLEC12 for disorders           About GeneDecksing

OMIM gene information: 607621    OMIM disorders: --

9 diseases for COLEC12:    About MalaCards

enamel erosion cerebral amyloid angiopathy major depressive disorder endotheliitis

cerebritis schizophrenia hepatitis b alzheimer's disease

hepatitis

Congresses - knowledge worth sharing:
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
Genetic Association Database (GAD): COLEC12
Human Genome Epidemiology (HuGE) Navigator: COLEC12 (2 documents)

Export disorders for COLEC12 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for COLEC12 gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with COLEC12)

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Molecular cloning and functional characterization of a human scavenger receptor with C-type lectin (SRCL), a novel member of a scavenger receptor family. (PubMed id 11162630)^{1, 2, 3, 9} Nakamura K.... Nakamura T. (2001)
Haplotype analysis of the human collectin placenta 1 (hCL-P1) gene. (PubMed id 12601552)^{1, 2, 9} Ohmori H.... Hata A. (2003)
Selective binding of the scavenger receptor C-type lectin to Lewis X trisaccharide and related glycan ligands. (PubMed id 15845541)^{1, 2, 9} Coombs P.J.... Taylor M.E. (2005)
The membrane-type collectin CL-P1 is a scavenger receptor on vascular endothelial cells. (PubMed id 11564734)^{1, 2, 9} Ohtani K.... Wakamiya N. (2001)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (2010)
SRCL/CL-P1 recognizes GalNAc and a carcinoma-associated antigen, Tn antigen. (PubMed id 12761161)^{1, 2} Yoshida T.... Suzuki R. (2003)
Expression and tissue localization of collectin placenta 1 (CL-P1, SRCL) in human tissues. (PubMed id 18423602)^{1, 9} Selman L....Hansen S. (2008)
Scavenger receptor collectin placenta 1 (CL-P1) predominantly mediates zymosan phagocytosis by human vascular endothelial cells. (PubMed id 19073604)^{1, 9} Jang S....Wakamiya N. (2009)
Possible role of scavenger receptor SRCL in the clearance of amyloid- beta in Alzheimer's disease. (PubMed id 16868960)^{2, 9} Nakamura K.... Nakamura T. (2006)
Scavenger receptor C-type lectin binds to the leukocyte cell surface glycan Lewis X by a novel mechanism. (PubMed id 17420244)^{2, 9} Feinberg H.... Weis W.I. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 81035	HGNC: 16016	AceView: COLEC12	Ensembl:ENSG00000158270	euGenes: HUgn81035
ECgene: COLEC12	Kegg: 81035	H-InvDB: COLEC12

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for COLEC12	Pharmacogenomics, SNPs, Pathways

Intellectual Property for COLEC12 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for COLEC12 gene:
Search GeneIP for patents involving COLEC12

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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Collectin Sub-Family Member 12

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