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COLEC12 Gene

protein-coding GIFtS: 59
GCID: GC18M000309

Collectin Sub-Family Member 12

Microbiology & Infectious Diseases Congress

See related diseases
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Collectin Sub-Family Member 12¹ ²		SCARA4² ³
CLP1² ³ ⁵		hCL-P1² ³
SRCL² ³ ⁵		collectin-12²
Collectin Placenta Protein 1² ³		Scavenger Receptor Class A, Member 4²
Nurse Cell Scavenger Receptor 2² ³		CL-P1³
Scavenger Receptor With C-Type Lectin² ³		Scavenger Receptor Class A Member 4³
NSR2² ³

External Ids:	HGNC: 16016¹	Entrez Gene: 81035²	Ensembl: ENSG00000158270⁷	OMIM: 607621⁵	UniProtKB: Q5KU26³

Export aliases for COLEC12 gene to outside databases

Previous GC identifers: GC18M000603 GC18M000306

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for COLEC12 Gene:

This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate

recognition domains. This protein is a scavenger receptor, a cell surface glycoprotein that displays several

functions associated with host defense. It can bind to carbohydrate antigens on microorganisms, facilitating

their recognition and removal. It also mediates the recognition, internalization, and degradation of oxidatively

modified low density lipoprotein by vascular endothelial cells. (provided by RefSeq, Oct 2011)

GeneCards Summary for COLEC12 Gene:

COLEC12 (collectin sub-family member 12) is a protein-coding gene. Diseases associated with COLEC12 include enamel erosion, and cerebral amyloid angiopathy. GO annotations related to this gene include scavenger receptor activity and signaling pattern recognition receptor activity. An important paralog of this gene is COL28A1.

UniProtKB/Swiss-Prot: COL12_HUMAN, Q5KU26

Function: Scavenger receptor that displays several functions associated with host defense. Promotes binding and

phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and

degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to

several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a

calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X

or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid beta in

Alzheimer disease

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000018.10 NT_010859.15 NC_018929.2

Regulatory elements:

Regulatory transcription factor binding sites in the COLEC12 gene promoter:
HFH-3 SRF AML1a SRF (504 AA) IRF-1 FOXI1 Nkx6-1 FOXO4 HFH-1 FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: COLEC12 promoter sequence

Search Chromatin IP Primers for COLEC12

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COLEC12

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.32 Ensembl cytogenetic band: 18p11.32 HGNC cytogenetic band: 18p11.32

COLEC12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COLEC12 gene location

GeneLoc information about chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18M000309: view genomic region (about GC identifiers)

Start:	319,355 bp from pter	End:	500,729 bp from pter
Size:	181,375 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: COL12_HUMAN, Q5KU26 (See protein sequence)

Recommended Name: Collectin-12

Size: 742 amino acids; 81515 Da

Subunit: The extracellular domain forms a stable trimer. The extracellular domain interacts with fibrillar beta

amyloid peptide

Sequence caution: Sequence=BAB39148.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;

1 PDB 3D structure from and Proteopedia for COLEC12:

2OX8 (3D)

Secondary accessions: Q6P9F2 Q8TCR2 Q8WZA4 Q9BY85 Q9BYH7

Explore the universe of human proteins at neXtProt for COLEC12: NX_Q5KU26

Explore proteomics data for COLEC12 at MOPED

Post-translational modifications:

Glycosylation² at Asn67, Asn159, Asn168, Asn271

Modification sites at PhosphoSitePlus

See COLEC12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_569057.1

ENSEMBL proteins:

ENSP00000383115

Reactome Protein details: Q5KU26

COLEC12 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for COLEC12 (CL-P1/COLEC12)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for COLEC12 OriGene Protein Over-expression Lysate for COLEC12 OriGene MassSpec for COLEC12 OriGene Custom Protein Services for COLEC12
	GenScript Custom Purified and Recombinant Proteins Services for COLEC12
	Novus Biologicals COLEC12 Proteins Novus Biologicals COLEC12 Lysates
	Sino Biological Recombinant Protein for COLEC12 Sino Biological Cell Lysate for COLEC12
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.

COLEC12 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for COLEC12 (CL-P1/COLEC12)
	Browse OriGene Antibodies OriGene Custom Antibody Services for COLEC12
	Novus Biologicals COLEC12 Antibodies
	Search for Antibodies for COLEC12 at Abcam
	Browse Antibodies at Cloud-Clone Corp.
	ThermoFisher Antibodies for COLEC12
	LSBio Antibodies in human, mouse, rat for COLEC12

COLEC12 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for COLEC12
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for COLEC12
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

COLEC: Collectins

5 InterPro protein domains:

IPR016187 C-type_lectin_fold

IPR018378 C-type_lectin_CS

IPR016186 C-type_lectin-like

IPR001304 C-type_lectin

IPR008160 Collagen

Graphical View of Domain Structure for InterPro Entry Q5KU26

ProtoNet protein and cluster: Q5KU26

2 Blocks protein domains:

IPB002353 Type II antifreeze protein signature

IPB008160 Collagen triple helix repeat

UniProtKB/Swiss-Prot: COL12_HUMAN, Q5KU26

Similarity: Contains 1 C-type lectin domain

Similarity: Contains 3 collagen-like domains

COLEC12 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: COL12_HUMAN, Q5KU26

Function: Scavenger receptor that displays several functions associated with host defense. Promotes binding and

phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and

degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to

several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a

calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X

or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid beta in

Alzheimer disease

Gene Ontology (GO): Selected molecular function terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005044	scavenger receptor activity	TAS	11162630
GO:0005534	galactose binding	NAS	11564734
GO:0008329	signaling pattern recognition receptor activity	IDA	11564734
GO:0030169	low-density lipoprotein particle binding	IDA	11564734
GO:0030246	carbohydrate binding	--	--

COLEC12 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for COLEC12:

Increased G1 DNA content

Proliferating cells

1 MGI phenotypic allele

for Colec12 (no phenotypes)

COLEC12 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for COLEC12

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for COLEC12

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for COLEC12

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for COLEC12

miRNA Products:		miRTarBase miRNAs that target COLEC12: hsa-mir-7-5p (MIRT025879), hsa-mir-9-5p (MIRT021483), hsa-mir-26b-5p (MIRT029943)

		Block miRNA regulation of human, mouse, rat COLEC12 using miScript Target Protectors
		7 qRT-PCR Assays for microRNAs that regulate COLEC12:
		hsa-miR-3685 hsa-miR-1290 hsa-miR-9 hsa-let-7g* hsa-miR-493* hsa-miR-155* hsa-let-7a-2*
		SwitchGear 3'UTR luciferase reporter plasmid: COLEC12 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for COLEC12
		Predesigned siRNA for gene silencing in human, mouse, rat COLEC12

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for COLEC12

Clone Products:		OriGene clones in human, mouse for COLEC12 (see all 6) OriGene ORF clones in mouse, rat for COLEC12 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: COLEC12 (NM_130386)
		Sino Biological Human cDNA Clone for COLEC12
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for COLEC12
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COLEC12

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for COLEC12
		Browse ESI BIO Cell Lines and PureStem Progenitors for COLEC12

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COLEC12

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

COL12_HUMAN, Q5KU26: Membrane; Single-pass type II membrane protein. Note=Forms clusters on the cell surface

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
extracellular	3
plasma membrane	3
cytosol	1
endoplasmic reticulum	1
golgi apparatus	1
mitochondrion	1
nucleus	1

About this image

Gene Ontology (GO): 4 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005581	collagen	IEA	--
GO:0005886	plasma membrane	TAS	--
GO:0016021	integral component of membrane	TAS	11162630
GO:0030666	endocytic vesicle membrane	TAS	--

COLEC12 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for COLEC12 About

See pathways by source

SuperPath

Contained pathways About

Binding and Uptake of Ligands by Scavenger Receptors

Binding and Uptake of Ligands by Scavenger Receptors

0.53

Scavenging by Class A Receptors

0.00

Phagosome

Phagosome

Pathways by source See SuperPaths
Show all pathways

1 Reactome Pathway for COLEC12

Scavenging by Class A Receptors

1 Kegg Pathway (Kegg details for COLEC12):

Phagosome

COLEC12 for pathways About GeneDecksing

Pathway & Disease-focused RT² Profiler PCR Arrays including COLEC12:

Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

Antifungal Response in human mouse rat

Interactions:

Search GeneGlobe Interaction Network for COLEC12

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for COLEC12 (Q5KU26³ ENSP00000383115⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EXOC1	Q9NV70³, ENSP00000326514⁴	I2D: score=2 STRING: ENSP00000326514
SGTA	ENSP00000221566⁴	STRING: ENSP00000221566
SGTB	ENSP00000370395⁴	STRING: ENSP00000370395

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Gene Ontology (GO): Selected biological process terms (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002221	pattern recognition receptor signaling pathway	IDA	11564734
GO:0006898	receptor-mediated endocytosis	TAS	11162630
GO:0006910	phagocytosis, recognition	IDA	11564734
GO:0006952	defense response	TAS	11162630
GO:0006955	immune response	--	--

COLEC12 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for COLEC12 (COL12)

3 HMDB Compounds for COLEC12 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
D-Galactose	(+)-Galactose (see all 14)	59-23-4	--
Lewis X trisaccharide	3-Fucosyl-N-acetyllactosamine (see all 8)	71208-06-5	--

2 Novoseek inferred chemical compound relationships for COLEC12 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
galactose	41.3	2	16670103 (1), 15845541 (1)
polysaccharide	39.6	4	16670103 (1), 17420244 (1), 15845541 (1)

COLEC12 for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for COLEC12 gene (2 alternative transcripts):

NM_130386.2 NM_030781.2

Unigene Cluster for COLEC12:

Collectin sub-family member 12

Hs.464422 [show with all ESTs]

Unigene Representative Sequence: NM_130386

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000400256(uc002kkm.3) ENST00000582147

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA Products:		Block miRNA regulation of human, mouse, rat COLEC12 using miScript Target Protectors
		7 qRT-PCR Assays for microRNAs that regulate COLEC12:
		hsa-miR-3685 hsa-miR-1290 hsa-miR-9 hsa-let-7g* hsa-miR-493* hsa-miR-155* hsa-let-7a-2*
		SwitchGear 3'UTR luciferase reporter plasmid: COLEC12 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for COLEC12
		Predesigned siRNA for gene silencing in human, mouse, rat COLEC12

Clone Products:		OriGene clones in human, mouse for COLEC12 (see all 6) OriGene ORF clones in mouse, rat for COLEC12 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: COLEC12 (NM_130386)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for COLEC12
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COLEC12

Primer Products:		OriGene qPCR primer pairs and template standards for COLEC12 OriGene qSTAR qPCR primer pairs in human, mouse for COLEC12
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat COLEC12
		QuantiTect SYBR Green Assays in human, mouse, rat COLEC12
		QuantiFast Probe-based Assays in human, mouse, rat COLEC12

Additional mRNA sequence:

AB005145.1 AB034251.1 AB038518.1 AL713657.1 BC060789.1

5 DOTS entries:

DT.455710 DT.91973502 DT.95310302 DT.97804571 DT.95371373

Selected AceView cDNA sequences (see all 106):

BQ030255 CF528303 CA392710 AL543001 AL541116 R74388 BX377133 N48549

AA775122 CR610483 CD632749 NM_030781 AW264006 BC060789 AI968658 W67228

AW316714 AW029149 AA977789 BQ004176 AW275816 AI147677 BQ021066 BP346167

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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COLEC12 expression in normal human tissues (normalized intensities) COLEC12 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GAGCCAAAGA

About this image

COLEC12 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 20) fully expand


Bone (Muscoskeletal System) fully expand to see all 5 entries
Zeugopod Long Bone

NULL (Uncategorized) fully expand to see all 4 entries
Definitive endoderm-like cells

Gut Tube (Gastrointestinal Tract) fully expand to see all 2 entries
Foregut

Brain (Nervous System) fully expand to see all 2 entries
Cerebral Cortex

Neural Crest (Gastrulation Derivatives) fully expand to see all 2 entries
PureStem 4D20.8, NCr-fac Progenitor

COLEC12 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

COLEC12 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.464422

UniProtKB/Swiss-Prot: COL12_HUMAN, Q5KU26

Tissue specificity: Expressed in perivascular macrophages. Expressed in plaques-surrounding reactive astrocytes

and in perivascular astrocytes associated with cerebral amyloid angiopathy (CAA) in the temporal cortex of

Alzheimer patient (at protein level). Strongly expressed in placenta. Moderately expressed in heart, skeletal

muscle, small intestine and lung. Weakly expressed in brain, colon, thymus and kidney. Expressed in nurse-like

cells. Expressed in reactive astrocytes and vascular/perivascular cells in the brain of Alzheimer patient

Pathway & Disease-focused RT² Profiler PCR Arrays including COLEC12:

Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

Antifungal Response in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for COLEC12 OriGene qSTAR qPCR primer pairs in human, mouse for COLEC12
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat COLEC12
		QuantiTect SYBR Green Assays in human, mouse, rat COLEC12
		QuantiFast Probe-based Assays in human, mouse, rat COLEC12

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COLEC12

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for COLEC12 gene from Selected species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Colec12^{1 , 5}	collectin sub-family member 12^{1, 5}	87.69(n)¹ 92.45(a)¹		18 (4.91 cM)⁵ 140792¹ NM_130449.2¹ NP_569716.2¹ 9707648⁵
chicken (Gallus gallus)	Aves	COLEC12¹	collectin sub-family member 12	76.03(n) 81.45(a)		421061 NM_001039599.1 NP_001034688.1
lizard (Anolis carolinensis)	Reptilia	COLEC12⁶	collectin sub-family member 12	76(a)	1 ↔ 1	4(39363120-39459939)
African clawed frog (Xenopus laevis)	Amphibia	Xl.19955²	Xenopus laevis transcribed sequence with strong similarity more	85.81(n)		BQ401058.1
zebrafish (Danio rerio)	Actinopterygii	idibd2826²	idibd2826	79.13(n)		338130 AI545067.1
worm (Caenorhabditis elegans)	Secernentea	col-187⁶ col-118⁶ (see all 14)	Protein COL-187 (col-187) mRNA, complete cds Protein COL-118, isoform a (col-118) mRNA, complet... (see all 14)	29(a) 29(a) (see all 14)	many ↔ many many ↔ many (see all 14)	X(16072903-16074852) WBGene00000760 IV(8848182-8849676) WBGene00000692

ENSEMBL Gene Tree for COLEC12 (if available)
TreeFam Gene Tree for COLEC12 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for COLEC12 gene

COL28A1² COL6A1² COL6A5² COLQ² COL6A6² COL6A2² SCARA3² COL17A1²

COL6A3²

5 SIMAP similar genes for COLEC12 using alignment to 1 protein entry: COL12_HUMAN:

CLEC6A SCARA3 FCER2 REG1B REG1A

COLEC12 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 18 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs181263935^1,2		--	309083(+)	`TCTGCC/TTTTGG`	1	--	ds500¹		0	--	--	--	--
rs58881684^1,2	C	--	309102(+)	`ACGCC-/ATACGT`	1	--	ds500¹		0	--	--	--	--
rs185538951^1,2		--	309179(+)	`CAGGGC/TCTTCC`	1	--	ds500¹		0	--	--	--	--
rs12458434^1,2	C,H	--	309233(+)	`TCCCCC/TACACC`	1	--	ds500¹		2		NA EA	122
rs675712^1,2	C,F,O,H	--	309311(+)	`CACACG/ATCAAG`	1	--	ds500¹		21		MN NS EA NA WA CSA	2510
rs189854777^1,2		--	309337(+)	`TGGGCA/TCAAGG`	1	--	ds500¹		0	--	--	--	--
rs2846611^1,2	C,F	--	309407(-)	`AAATAT/CCCTTG`	1	--	ds500¹		5		NA EA	246
rs199877238^1,2		--	309499(+)	`TATAT-/ACACATG`	1	--	ut3¹		0	--	--	--	--
rs12458488^1,2	C,F,H	--	309500(+)	`ATATAT/CACATG`	1	--	ut3¹ ese³		3		NA	8
rs10660^1,2	C,F,H	--	309581(-)	`CTAGGG/TTTTCC`	1	--	ut3¹ ese³		23		MN NS EA NA WA CSA	2566

HapMap Linkage Disequilibrium report for COLEC12 (319355 - 500729 bp)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for COLEC12 (see all 11): About this table

Variant ID	Type	Subtype	PubMed ID
nsv2177	CNV	Insertion	18451855
nsv517980	CNV	Loss	19592680
nsv510444	CNV	Loss	20534489
nsv909290	CNV	Loss	21882294
nsv909289	CNV	Loss	21882294
nsv522804	CNV	Loss	19592680
nsv909288	CNV	Loss	21882294
nsv909291	CNV	Gain	21882294
nsv518642	CNV	Gain	19592680
nsv909287	CNV	Gain	21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 607621 OMIM disorders: --

12 diseases for COLEC12: About MalaCards

enamel erosion cerebral amyloid angiopathy major depressive disorder endotheliitis

meningitis cerebritis bipolar disorder schizophrenia

hepatitis b alzheimer's disease obesity hepatitis

COLEC12 for disorders About GeneDecksing

Congresses - knowledge worth sharing:
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
Genetic Association Database (GAD): COLEC12
Human Genome Epidemiology (HuGE) Navigator: COLEC12 (2 documents)

Export disorders for COLEC12 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for COLEC12 gene, integrated from 10 sources (see all 24):
(articles sorted by number of sources associating them with COLEC12)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning and functional characterization of a human scavenger receptor with C-type lectin (SRCL), a novel member of a scavenger receptor family. (PubMed id 11162630)^{1, 2, 3, 9} Nakamura K.... Nakamura T. (Biochem. Biophys. Res. Commun. 2001)
Haplotype analysis of the human collectin placenta 1 (hCL-P1) gene. (PubMed id 12601552)^{1, 2, 9} Ohmori H.... Hata A. (J. Hum. Genet. 2003)
Selective binding of the scavenger receptor C-type lectin to Lewis X trisaccharide and related glycan ligands. (PubMed id 15845541)^{1, 2, 9} Coombs P.J.... Taylor M.E. (J. Biol. Chem. 2005)
The membrane-type collectin CL-P1 is a scavenger receptor on vascular endothelial cells. (PubMed id 11564734)^{1, 2, 9} Ohtani K.... Wakamiya N. (J. Biol. Chem. 2001)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
SRCL/CL-P1 recognizes GalNAc and a carcinoma-associated antigen, Tn antigen. (PubMed id 12761161)^{1, 2} Yoshida T.... Suzuki R. (J. Biochem. 2003)
Expression and tissue localization of collectin placenta 1 (CL-P1, SRCL) in human tissues. (PubMed id 18423602)^{1, 9} Selman L....Hansen S. (Mol. Immunol. 2008)
Scavenger receptor collectin placenta 1 (CL-P1) predominantly mediates zymosan phagocytosis by human vascular endothelial cells. (PubMed id 19073604)^{1, 9} Jang S....Wakamiya N. (J. Biol. Chem. 2009)
Possible role of scavenger receptor SRCL in the clearance of amyloid- beta in Alzheimer's disease. (PubMed id 16868960)^{2, 9} Nakamura K.... Nakamura T. (J. Neurosci. Res. 2006)
Scavenger receptor C-type lectin binds to the leukocyte cell surface glycan Lewis X by a novel mechanism. (PubMed id 17420244)^{2, 9} Feinberg H.... Weis W.I. (J. Biol. Chem. 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 81035	HGNC: 16016	AceView: COLEC12	Ensembl:ENSG00000158270	euGenes: HUgn81035
ECgene: COLEC12	Kegg: 81035	H-InvDB: COLEC12

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for COLEC12	Pharmacogenomics, SNPs, Pathways

Intellectual Property for COLEC12 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for COLEC12 gene:
Search GeneIP for patents involving COLEC12

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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COLEC12 Gene

Collectin Sub-Family Member 12

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