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COLEC11 Gene

protein-coding   GIFtS: 55
GCID: GC02P003642

Collectin Sub-Family Member 11

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Collectin Sub-Family Member 111 2     CL-K1-II2
Collectin K11 2     CL-K1-IIa2
Collectin Kidney Protein 12 3     CL-K1-IIb2
3MC22 5     collectin-112
CLK12 5     CL-K13
CL-K1-I2     

External Ids:    HGNC: 172131   Entrez Gene: 789892   Ensembl: ENSG000001180047   OMIM: 6125025   UniProtKB: Q9BWP83   

Export aliases for COLEC11 gene to outside databases

Previous GC identifers: GC00U991131 GC02P003285 GC02P003207 GC02P003136 GC02P003620 GC02P003583


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for COLEC11 Gene:
This gene encodes a member of the collectin family of C-type lectins that possess collagen-like sequences and
carbohydrate recognition domains. Collectins are secreted proteins that play important roles in the innate immune
system by binding to carbohydrate antigens on microorganisms, facilitating their recognition and removal. The
encoded protein binds to multiple sugars with a preference for fucose and mannose. Mutations in this gene are a
cause of 3MC syndrome-2. Alternatively spliced transcript variants encoding multiple isoforms have been observed
for this gene. (provided by RefSeq, Dec 2011)

GeneCards Summary for COLEC11 Gene:
COLEC11 (collectin sub-family member 11) is a protein-coding gene. Diseases associated with COLEC11 include 3mc syndrome 2, and michels syndrome. GO annotations related to this gene include mannose binding. An important paralog of this gene is SFTPA1.

UniProtKB/Swiss-Prot: COL11_HUMAN, Q9BWP8
Function: Lectin that binds to various sugars including fucose and mannose. Has a higher affinity for fucose
compared to mannose. Does not bind to glucose, N-acetylglucosamine and N-acetylgalactosamine. Also binds
lipopolysaccharides (LPS). Involved in fundamental development serving as a guidance cue for neural crest cell
migration (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005334.17  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the COLEC11 gene promoter:
         STAT5B   IRF-1   STAT5A   Tal-1beta   YY1   GATA-6   E2F-1   E2F   Ik-2   HFH-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOLEC11 promoter sequence
   Search Chromatin IP Primers for COLEC11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COLEC11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25.3   Ensembl cytogenetic band:  2p25.3   HGNC cytogenetic band: 2p25.3

COLEC11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COLEC11 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P003642:  view genomic region     (about GC identifiers)

Start:
3,642,426 bp from pter      End:
3,692,048 bp from pter
Size:
49,623 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: COL11_HUMAN, Q9BWP8 (See protein sequence)
Recommended Name: Collectin-11 precursor  
Size: 271 amino acids; 28665 Da
Secondary accessions: A1IGE4 A1IGE5 A1IGE6 A7VJJ2 A7VJJ3 A7VJJ4 A7VJJ5 B2R9M5 B4E1G0 J3KQY9
Q5CZ85 Q7Z6N1
Alternative splicing: 10 isoforms:  Q9BWP8-1   Q9BWP8-2   Q9BWP8-3   Q9BWP8-4   Q9BWP8-5   Q9BWP8-6   Q9BWP8-7   Q9BWP8-8   
Q9BWP8-9   Q9BWP8-10   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for COLEC11: NX_Q9BWP8

Explore proteomics data for COLEC11 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See COLEC11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (10 alternative transcripts): 
    NP_001242911.1  NP_001242912.1  NP_001242913.1  NP_001242914.1  NP_001242915.1  NP_001242916.1  NP_001242917.1  NP_001242918.1  
    NP_076932.1  NP_954705.1  

    ENSEMBL proteins: 
     ENSP00000236693   ENSP00000339168   ENSP00000410919   ENSP00000393167   ENSP00000385130  
     ENSP00000384882   ENSP00000385827   ENSP00000385653   ENSP00000411770   ENSP00000371494  
    Reactome Protein details: Q9BWP8

    COLEC11 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    COLEC: Collectins

    5 InterPro protein domains:
     IPR016187 C-type_lectin_fold
     IPR018378 C-type_lectin_CS
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin
     IPR008160 Collagen

    Graphical View of Domain Structure for InterPro Entry Q9BWP8

    ProtoNet protein and cluster: Q9BWP8

    2 Blocks protein domains:
    IPB008160 Collagen triple helix repeat
    IPB008161 Collagen helix repeat


    UniProtKB/Swiss-Prot: COL11_HUMAN, Q9BWP8
    Similarity: Belongs to the COLEC10/COLEC11 family
    Similarity: Contains 1 C-type lectin domain
    Similarity: Contains 1 collagen-like domain


    COLEC11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COL11_HUMAN, Q9BWP8
    Function: Lectin that binds to various sugars including fucose and mannose. Has a higher affinity for fucose
    compared to mannose. Does not bind to glucose, N-acetylglucosamine and N-acetylgalactosamine. Also binds
    lipopolysaccharides (LPS). Involved in fundamental development serving as a guidance cue for neural crest cell
    migration (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005537mannose binding IEA--
    GO:0030246carbohydrate binding ----
         
    COLEC11 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Colec11 (no phenotypes)

    COLEC11 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Colec11tm1Lex for COLEC11

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for COLEC11
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    miRNA
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    miRTarBase miRNAs that target COLEC11:
    hsa-mir-215-5p (MIRT024633), hsa-mir-186-5p (MIRT045167), hsa-mir-192-5p (MIRT026392)

    Block miRNA regulation of human, mouse, rat COLEC11 using miScript Target Protectors
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    Sino Biological Human cDNA Clone for COLEC11
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    COL11_HUMAN, Q9BWP8: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    cytosol1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005581collagen IEA--

    COLEC11 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for COLEC11 About    
    See pathways by source

    SuperPathContained pathways About
    1Binding and Uptake of Ligands by Scavenger Receptors
    Binding and Uptake of Ligands by Scavenger Receptors0.53
    Scavenging by Class A Receptors0.00
    2Phagosome
    Phagosome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for COLEC11
        Scavenging by Class A Receptors


    1 Kegg Pathway  (Kegg details for COLEC11):
        Phagosome


    COLEC11 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for COLEC11
    Interactions:

        Search GeneGlobe Interaction Network for COLEC11

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--
    GO:0032502developmental process ISS--

    COLEC11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for COLEC11 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    (5Z)-7-OxozeaenolPotent and selective TAK1 MAPKKK inhibitor[66018-38-0]
    GSK 650394Serum- and glucocorticoid-regulated kinase (SGK) inhibitor[890842-28-1]
    IPA 3Group I p21-activated kinase (PAK) inhibitor[42521-82-4]
    CGP 57380Selective inhibitor of Mnk1[522629-08-9]
    AZ 3146Potent and selective monopolar spindle 1 (Mps1) kinase inhibitor[1124329-14-1]



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for COLEC11 gene (10 alternative transcripts): 
    NM_001255982.1  NM_001255983.1  NM_001255984.1  NM_001255985.1  NM_001255986.1  NM_001255987.1  NM_001255988.1  NM_001255989.1  
    NM_024027.4  NM_199235.2  

    Unigene Cluster for COLEC11:

    Collectin sub-family member 11
    Hs.32603  [show with all ESTs]
    Unigene Representative Sequence: NR_045659
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000419002 ENST00000487365 ENST00000460971 ENST00000236693(uc002qxz.3 uc002qya.3 uc002qyb.3 uc002qyc.3 uc010ewo.3)
    ENST00000349077 ENST00000416132 ENST00000438814 ENST00000403096(uc010ewp.3)
    ENST00000402794(uc010ewq.3) ENST00000404205(uc010ews.3) ENST00000402922(uc010ewr.3)
    ENST00000418971 ENST00000382062
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat COLEC11
      QuantiFast Probe-based Assays in human, mouse, rat COLEC11

    Additional mRNA sequence: 

    AB119525.1 AB119650.1 AB119651.1 AB119652.1 AB119684.1 AB119685.1 AB119686.1 AB119687.1 
    AK303824.1 AK313840.1 AY358439.1 BC000078.2 BC009951.2 CR936641.1 NR_045659.1 

    5 DOTS entries:

    DT.309348  DT.91742514  DT.100723266  DT.100780755  DT.91742604 

    Selected AceView cDNA sequences (see all 86):

    BF206197 BF206235 BE313758 BF312666 BE312003 BE313499 AY358439 NM_024027 
    BU147034 AA456055 BQ069775 BP338791 BX427124 BM987489 CR599770 BC000078 
    AA908360 CR604552 BC009951 BM547424 BF312192 NM_199235 BF206254 BE261369 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for COLEC11    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
    SP1:                          -                                             
    SP2:                          -           -                                 
    SP3:                                                                        


    ECgene alternative splicing isoforms for COLEC11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    COLEC11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCCAGCCA
    COLEC11 Expression
    About this image


    COLEC11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Endothelium (Cardiovascular System)
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
     
     Extraembryonic Mesoderm (Extraembryonic Tissues)
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
     
     Testis (Reproductive System)
     
     Gall Bladder (Hepatobiliary System)
     
     Dermis (Integumentary System)
    COLEC11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    COLEC11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.32603

    UniProtKB/Swiss-Prot: COL11_HUMAN, Q9BWP8
    Tissue specificity: Ubiquitous

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COLEC11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for COLEC11 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Colec111 , 5 collectin sub-family member 111, 5 86.96(n)1
    91.88(a)1
      12 (10.98 cM)5
    716931  NM_027866.11  NP_082142.11 
     285941735 
    chicken
    (Gallus gallus)
    Aves COLEC111 collectin sub-family member 11 77.61(n)
    82.66(a)
      428649  NM_001044665.1  NP_001038130.1 
    lizard
    (Anolis carolinensis)
    Reptilia COLEC116
    collectin sub-family member 11
    75(a)
    1 ↔ 1
    GL343342.1(1150338-1166068)
    African clawed frog
    (Xenopus laevis)
    Amphibia colec11-prov2 collectin sub-family member 11 74.61(n)    BC056052.1 
    zebrafish
    (Danio rerio)
    Actinopterygii colec111 collectin sub-family member 11 69(n)
    69(a)
      492459  NM_001007331.1  NP_001007332.1 


    ENSEMBL Gene Tree for COLEC11 (if available)
    TreeFam Gene Tree for COLEC11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for COLEC11 gene
    SFTPA12  SFTPD2  COLEC102  MBL22  SFTPA22  
    10 SIMAP similar genes for COLEC11 using alignment to 3 protein entries:     COL11_HUMAN (see all proteins):
    COLEC10    MSR1    C1QTNF7    COL16A1    COL4A6    COL21A1
    COL6A6    GLDN    COL13A1    COL7A1

    COLEC11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for COLEC11 (see all 1466)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0659024
    3MC syndrome 2 (3MC2)4--see VAR_0659022 G S mis40--------
    VAR_0659014
    3MC syndrome 2 (3MC2)4--see VAR_0659012 S P mis40--------
    rs746178861,2
    C,F--3624648(+) TTAGCT/CGTATC 4 -- us2k14Minor allele frequency- C:0.15NA WA 242
    rs1178981981,2
    C,F--3624787(+) GTGGGC/G/TGAGCC 4 -- us2k11EA 120
    rs1391362641,2
    --3640456(+) GAAGAC/TGACGT 6 -- us2k10--------
    rs1155642511,2
    F--3640606(+) ATTTTG/TGTGTC 6 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1120375091,2
    C--3640664(+) TATTAT/-TTTTT 6 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs75697981,2
    C,F--3640689(+) cgctcC/Tgtcac 6 -- us2k12Minor allele frequency- T:0.50WA NA 4
    rs1898807461,2
    --3640719(+) CACAAC/GCTCAA 6 -- us2k10--------
    rs1925244361,2
    --3640747(+) CTCCCA/GGAGTC 6 -- us2k10--------

    HapMap Linkage Disequilibrium report for COLEC11 (3642426 - 3692048 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for COLEC11:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2719523CNV Deletion23290073
    esv1749783CNV Insertion17803354
    nsv214922CNV Insertion16902084
    nsv873590CNV Loss21882294
    nsv468950CNV Loss19166990
    nsv873591CNV Gain21882294
    dgv4043n71CNV Gain21882294
    nsv468961CNV Gain19166990
    nsv818922CNV Gain17921354

    Human Gene Mutation Database (HGMD): COLEC11
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing COLEC11
    DNA2.0 Custom Variant and Variant Library Synthesis for COLEC11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612502   
    OMIM disorders: 265050  
    UniProtKB/Swiss-Prot: COL11_HUMAN, Q9BWP8
  • 3MC syndrome 2 (3MC2) [MIM:265050]: A disorder characterized by facial dysmorphism that includes
    hypertelorism, blepharophimosis, blepharoptosis and highly arched eyebrows, cleft lip and/or palate,
    craniosynostosis, learning disability and genital, limb and vesicorenal anomalies. The term 3MC syndrome includes
    Carnevale, Mingarelli, Malpuech, and Michels syndromes. Note=The disease is caused by mutations affecting the
    gene represented in this entry

  • 13 diseases for COLEC11:    
    About MalaCards
    3mc syndrome 2    michels syndrome    3mc syndrome 1    blepharophimosis
    learning disability    craniosynostosis    cleft lip    kidney disease
    hepatitis b    hypertension    hepatitis    multiple myeloma
    myeloma


    COLEC11 for disorders           About GeneDecksing

    Genetic Association Database (GAD): COLEC11
    Human Genome Epidemiology (HuGE) Navigator: COLEC11 (4 documents)

    Export disorders for COLEC11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for COLEC11 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with COLEC11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in lectin complement pathway genes COLEC11 and MASP1 cause 3MC syndrome. (PubMed id 21258343)1, 2 Rooryck C.... Beales P.L. (Nat. Genet. 2011)
    2. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (Am. J. Hypertens. 2010)
    3. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2010)
    4. Association of gene polymorphisms with chronic kidney disease in Japanese individuals. (PubMed id 19724895)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2009)
    5. Identification and characterization of a novel human collectin CL- K1. (PubMed id 17179669)1, 2 Keshi H.... Wakamiya N. (Microbiol. Immunol. 2006)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    7. Heteromeric complexes of native collectin kidney 1 and collectin liver 1 are found in the circulation with MASPs and activate the complement system. (PubMed id 24174618)1 Henriksen M.L....Hansen S. (J. Immunol. 2013)
    8. Collectin-11/MASP complex formation triggers activation of the lectin complement pathway--the fifth lectin pathway initiation complex. (PubMed id 23220946)1 Ma Y.J....Garred P. (J Innate Immun 2013)
    9. Characterization of the interaction between collectin 11 (CL-11, CL-K1) and nucleic acids. (PubMed id 23954398)1 Henriksen M.L....Hansen S. (Mol. Immunol. 2013)
    10. Comparison of human blood concentrations of collectin kidney 1 and mannan-binding lectin. (PubMed id 21893516)1 Yoshizaki T....Wakamiya N. (J. Biochem. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 78989 HGNC: 17213 AceView: COLEC11 Ensembl:ENSG00000118004 euGenes: HUgn78989
    ECgene: COLEC11 Kegg: 78989 H-InvDB: COLEC11

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for COLEC11 Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_225

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for COLEC11 gene:
    Search GeneIP for patents involving COLEC11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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