Aliases for COLEC11 Gene
External Ids for COLEC11 Gene
Previous GeneCards Identifiers for COLEC11 Gene
This gene encodes a member of the collectin family of C-type lectins that possess collagen-like sequences and carbohydrate recognition domains. Collectins are secreted proteins that play important roles in the innate immune system by binding to carbohydrate antigens on microorganisms, facilitating their recognition and removal. The encoded protein binds to multiple sugars with a preference for fucose and mannose. Mutations in this gene are a cause of 3MC syndrome-2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
GeneCards Summary for COLEC11 Gene
COLEC11 (Collectin Subfamily Member 11) is a Protein Coding gene. Diseases associated with COLEC11 include 3Mc Syndrome 2 and 3Mc Syndrome. Among its related pathways are Immune System and Creation of C4 and C2 activators. GO annotations related to this gene include mannose binding. An important paralog of this gene is MBL2.
UniProtKB/Swiss-Prot for COLEC11 Gene
Lectin that binds to various sugars including fucose and mannose. Has a higher affinity for fucose compared to mannose. Does not bind to glucose, N-acetylglucosamine and N-acetylgalactosamine. Also binds lipopolysaccharides (LPS). Involved in fundamental development serving as a guidance cue for neural crest cell migration (By similarity).