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Aliases for COLEC10 Gene

Aliases for COLEC10 Gene

  • Collectin Subfamily Member 10 2 3 5
  • Collectin Sub-Family Member 10 (C-Type Lectin) 2 3
  • Collectin Liver Protein 1 3 4
  • Collectin-34 3 4
  • CL-34 3 4
  • CLL1 3 4
  • Collectin Liver 1 3
  • CL-L1 4

External Ids for COLEC10 Gene

Previous GeneCards Identifiers for COLEC10 Gene

  • GC08P119066
  • GC08U900019
  • GC08P119676
  • GC08P120036
  • GC08P120148
  • GC08P115407
  • GC08P120007

Summaries for COLEC10 Gene

Entrez Gene Summary for COLEC10 Gene

  • This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. The other members of this family are secreted proteins and bind to carbohydrate antigens on microorganisms facilitating their recognition and removal. This gene product is a cytosolic protein, a characteristic that suggests that it may have different biological functions than other C-lectins. [provided by RefSeq, Jul 2008]

GeneCards Summary for COLEC10 Gene

COLEC10 (Collectin Subfamily Member 10) is a Protein Coding gene. Diseases associated with COLEC10 include 3mc syndrome. Among its related pathways are Creation of C4 and C2 activators and Immune System. GO annotations related to this gene include mannose binding. An important paralog of this gene is COLEC11.

UniProtKB/Swiss-Prot for COLEC10 Gene

  • Lectin that binds to various sugars: galactose > mannose = fucose > N-acetylglucosamine > N-acetylgalactosamine.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COLEC10 Gene

Genomics for COLEC10 Gene

Regulatory Elements for COLEC10 Gene

Enhancers for COLEC10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around COLEC10 on UCSC Golden Path with GeneCards custom track

Promoters for COLEC10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around COLEC10 on UCSC Golden Path with GeneCards custom track

Genomic Location for COLEC10 Gene

Chromosome:
8
Start:
118,952,240 bp from pter
End:
119,108,455 bp from pter
Size:
156,216 bases
Orientation:
Plus strand

Genomic View for COLEC10 Gene

Genes around COLEC10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COLEC10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COLEC10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COLEC10 Gene

Proteins for COLEC10 Gene

  • Protein details for COLEC10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6Z7-COL10_HUMAN
    Recommended name:
    Collectin-10
    Protein Accession:
    Q9Y6Z7
    Secondary Accessions:
    • Q3SYH6
    • Q6UW19

    Protein attributes for COLEC10 Gene

    Size:
    277 amino acids
    Molecular mass:
    30705 Da
    Quaternary structure:
    No Data Available

neXtProt entry for COLEC10 Gene

Proteomics data for COLEC10 Gene at MOPED

Post-translational modifications for COLEC10 Gene

  • Glycosylation at Asn 258
  • Modification sites at PhosphoSitePlus

Other Protein References for COLEC10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for COLEC10 Gene

Domains & Families for COLEC10 Gene

Gene Families for COLEC10 Gene

Suggested Antigen Peptide Sequences for COLEC10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6Z7

UniProtKB/Swiss-Prot:

COL10_HUMAN :
  • Contains 1 C-type lectin domain.
  • Belongs to the COLEC10/COLEC11 family.
Domain:
  • Contains 1 C-type lectin domain.
  • Contains 1 collagen-like domain.
Family:
  • Belongs to the COLEC10/COLEC11 family.
genes like me logo Genes that share domains with COLEC10: view

Function for COLEC10 Gene

Molecular function for COLEC10 Gene

UniProtKB/Swiss-Prot Function:
Lectin that binds to various sugars: galactose > mannose = fucose > N-acetylglucosamine > N-acetylgalactosamine.

Phenotypes for COLEC10 Gene

GenomeRNAi human phenotypes for COLEC10:
genes like me logo Genes that share phenotypes with COLEC10: view

Animal Model Products

  • Taconic Biosciences Mouse Models for COLEC10

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COLEC10 Gene

Localization for COLEC10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COLEC10 Gene

Secreted. Note=According to PubMed:10224141, cytoplasmic.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COLEC10 Gene COMPARTMENTS Subcellular localization image for COLEC10 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for COLEC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005581 collagen trimer IEA --
genes like me logo Genes that share ontologies with COLEC10: view

Pathways & Interactions for COLEC10 Gene

genes like me logo Genes that share pathways with COLEC10: view

Pathways by source for COLEC10 Gene

Interacting Proteins for COLEC10 Gene

Gene Ontology (GO) - Biological Process for COLEC10 Gene

None

No data available for SIGNOR curated interactions for COLEC10 Gene

Drugs & Compounds for COLEC10 Gene

No Compound Related Data Available

Transcripts for COLEC10 Gene

mRNA/cDNA for COLEC10 Gene

(4) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for COLEC10 Gene

Collectin sub-family member 10 (C-type lectin):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COLEC10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1: -
SP2:

Relevant External Links for COLEC10 Gene

GeneLoc Exon Structure for
COLEC10
ECgene alternative splicing isoforms for
COLEC10

Expression for COLEC10 Gene

mRNA expression in normal human tissues for COLEC10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for COLEC10 Gene

This gene is overexpressed in Liver (x42.3).

Protein differential expression in normal tissues from HIPED for COLEC10 Gene

This gene is overexpressed in Serum (53.2) and Plasma (14.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for COLEC10 Gene



SOURCE GeneReport for Unigene cluster for COLEC10 Gene Hs.176615

mRNA Expression by UniProt/SwissProt for COLEC10 Gene

Q9Y6Z7-COL10_HUMAN
Tissue specificity: Highly expressed in liver, placenta and adrenal gland. Moderately expressed in small intestine, lung, stomach and prostate. Weakly expressed in trachea and spleen.
genes like me logo Genes that share expression patterns with COLEC10: view

Protein tissue co-expression partners for COLEC10 Gene

Primer Products

In Situ Assay Products

Orthologs for COLEC10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for COLEC10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia COLEC10 35
  • 90.13 (n)
  • 93.5 (a)
COLEC10 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COLEC10 35
  • 91.46 (n)
  • 94.22 (a)
COLEC10 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Colec10 35
  • 86.04 (n)
  • 88.81 (a)
Colec10 16
Colec10 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia COLEC10 35
  • 99.64 (n)
  • 99.64 (a)
COLEC10 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Colec10 35
  • 86.59 (n)
  • 88.77 (a)
oppossum
(Monodelphis domestica)
Mammalia COLEC10 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves COLEC10 35
  • 73.01 (n)
  • 69.78 (a)
COLEC10 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COLEC10 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia colec10 35
  • 68.82 (n)
  • 64.64 (a)
zebrafish
(Danio rerio)
Actinopterygii COLEC10 36
  • 42 (a)
OneToOne
Species with no ortholog for COLEC10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COLEC10 Gene

ENSEMBL:
Gene Tree for COLEC10 (if available)
TreeFam:
Gene Tree for COLEC10 (if available)

Paralogs for COLEC10 Gene

Paralogs for COLEC10 Gene

(1) SIMAP similar genes for COLEC10 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with COLEC10: view

Variants for COLEC10 Gene

Sequence variations from dbSNP and Humsavar for COLEC10 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2046429 -- 119,061,442(+) gtatt(G/T)aaaaa intron-variant
rs2062375 -- 118,965,553(+) ATGCT(C/G)TAAAT intron-variant
rs2062376 -- 118,997,770(-) TTCTA(C/G)TAATG intron-variant
rs2062377 -- 118,995,181(-) TGCAA(A/T)TCAAT intron-variant
rs2200397 -- 119,028,442(+) CTCAG(A/T)ATCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COLEC10 Gene

Variant ID Type Subtype PubMed ID
essv8481 CNV CNV 17122850
essv5532 CNV CNV 17122850
esv2674983 CNV Deletion 23128226
esv2668821 CNV Deletion 23128226
esv22200 CNV Loss 19812545

Variation tolerance for COLEC10 Gene

Residual Variation Intolerance Score: 71.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.52; 29.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COLEC10 Gene

HapMap Linkage Disequilibrium report
COLEC10
Human Gene Mutation Database (HGMD)
COLEC10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COLEC10 Gene

Disorders for COLEC10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for COLEC10 Gene - From: DISEASES

Disorder Aliases PubMed IDs
3mc syndrome
  • craniofacial-ulnar-renal syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for COLEC10

Genetic Association Database (GAD)
COLEC10
Human Genome Epidemiology (HuGE) Navigator
COLEC10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COLEC10
genes like me logo Genes that share disorders with COLEC10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for COLEC10 Gene

Publications for COLEC10 Gene

  1. Molecular cloning of a novel human collectin from liver (CL-L1). (PMID: 10224141) Ohtani K. … Wakamiya N. (J. Biol. Chem. 1999) 2 3 4 23 67
  2. Molecular cloning of mouse collectin liver 1. (PMID: 12450124) Kawai T. … Wakamiya N. (Biosci. Biotechnol. Biochem. 2002) 3 23
  3. Gene-smoking interactions identify several novel blood pressure loci in the Framingham Heart Study. (PMID: 25189868) Sung Y.J. … Rao D.C. (Am. J. Hypertens. 2015) 3
  4. Genetic variation of COLEC10 and COLEC11 and association with serum levels of collectin liver 1 (CL-L1) and collectin kidney 1 (CL-K1). (PMID: 25710878) Bayarri-Olmos R. … Munthe-Fog L. (PLoS ONE 2015) 3
  5. Collectin liver 1 and collectin kidney 1 and other complement-associated pattern recognition molecules in systemic lupus erythematosus. (PMID: 26154564) Troldborg A. … Stengaard-Pedersen K. (Clin. Exp. Immunol. 2015) 3

Products for COLEC10 Gene

Sources for COLEC10 Gene

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