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Aliases for COLCA2 Gene

Aliases for COLCA2 Gene

  • Colorectal Cancer Associated 2 2 3 5
  • Cancer Susceptibility Candidate Protein 13 3 4
  • Cancer Susceptibility Candidate 13 2 3
  • C11orf93 3 4
  • CASC13 3 4
  • Chromosome 11 Open Reading Frame 93 2
  • Colorectal Cancer Associated Two 3

External Ids for COLCA2 Gene

Previous HGNC Symbols for COLCA2 Gene

  • C11orf93

Previous GeneCards Identifiers for COLCA2 Gene

  • GC11P111170

Summaries for COLCA2 Gene

GeneCards Summary for COLCA2 Gene

COLCA2 (Colorectal Cancer Associated 2) is a Protein Coding gene. Diseases associated with COLCA2 include colorectal cancer.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COLCA2 Gene

Genomics for COLCA2 Gene

Regulatory Elements for COLCA2 Gene

Enhancers for COLCA2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around COLCA2 on UCSC Golden Path with GeneCards custom track

Promoters for COLCA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around COLCA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for COLCA2 Gene

Chromosome:
11
Start:
111,298,546 bp from pter
End:
111,308,735 bp from pter
Size:
10,190 bases
Orientation:
Plus strand

Genomic View for COLCA2 Gene

Genes around COLCA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COLCA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COLCA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COLCA2 Gene

Proteins for COLCA2 Gene

  • Protein details for COLCA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8K830-COLC2_HUMAN
    Recommended name:
    Colorectal cancer-associated protein 2
    Protein Accession:
    A8K830
    Secondary Accessions:
    • E9PMJ8
    • Q2TBJ3
    • V5LD62
    • V5LDI3
    • V5LDV1
    • V5LE09
    • V5LEU3

    Protein attributes for COLCA2 Gene

    Size:
    154 amino acids
    Molecular mass:
    16850 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI10080.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AP002448; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for COLCA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COLCA2 Gene

Proteomics data for COLCA2 Gene at MOPED

Post-translational modifications for COLCA2 Gene

No Post-translational modifications

Other Protein References for COLCA2 Gene

No data available for DME Specific Peptides for COLCA2 Gene

Domains & Families for COLCA2 Gene

Protein Domains for COLCA2 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with COLCA2: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for COLCA2 Gene

Function for COLCA2 Gene

Phenotypes for COLCA2 Gene

genes like me logo Genes that share phenotypes with COLCA2: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for COLCA2 Gene

Localization for COLCA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COLCA2 Gene

Cytoplasm.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for COLCA2 Gene

Pathways & Interactions for COLCA2 Gene

SuperPathways for COLCA2 Gene

No Data Available

Interacting Proteins for COLCA2 Gene

Gene Ontology (GO) - Biological Process for COLCA2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for COLCA2 Gene

Drugs & Compounds for COLCA2 Gene

No Compound Related Data Available

Transcripts for COLCA2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for COLCA2 Gene

No ASD Table

Relevant External Links for COLCA2 Gene

GeneLoc Exon Structure for
COLCA2
ECgene alternative splicing isoforms for
COLCA2

Expression for COLCA2 Gene

mRNA expression in normal human tissues for COLCA2 Gene

mRNA Expression by UniProt/SwissProt for COLCA2 Gene

A8K830-COLC2_HUMAN
Tissue specificity: Expressed in many cell types of epithelial, mesenchymal and hematopoietic origins.
genes like me logo Genes that share expression patterns with COLCA2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for COLCA2 Gene

Orthologs for COLCA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for COLCA2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC100294918 35
  • 83 (n)
  • 76.11 (a)
dog
(Canis familiaris)
Mammalia COLCA2 35
  • 84.46 (n)
  • 77.69 (a)
COLCA2 36
  • 53 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm684 35
  • 78.34 (n)
  • 67.93 (a)
Gm684 16
Gm684 36
  • 41 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia COLCA2 35
  • 99.47 (n)
  • 99.2 (a)
COLCA2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1563866 35
  • 77.73 (n)
  • 68.42 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia COLCA2 36
  • 27 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC101751781 35
  • 57.81 (n)
  • 46.41 (a)
COLCA2 36
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COLCA2 36
  • 21 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734888 35
  • 52.95 (n)
  • 39.82 (a)
Species with no ortholog for COLCA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for COLCA2 Gene

ENSEMBL:
Gene Tree for COLCA2 (if available)
TreeFam:
Gene Tree for COLCA2 (if available)

Paralogs for COLCA2 Gene

No data available for Paralogs for COLCA2 Gene

Variants for COLCA2 Gene

Sequence variations from dbSNP and Humsavar for COLCA2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1046872 -- 111,308,665(+) TTTCA(A/G)TTGTT utr-variant-3-prime
rs2002562 -- 111,308,466(+) ATGGC(A/G)TGGGT utr-variant-3-prime
rs7121716 -- 111,308,994(+) aaaat(A/C)caaaa downstream-variant-500B
rs11824134 -- 111,307,707(+) TCCAG(C/G)GTGCC intron-variant
rs7930041 -- 111,308,948(+) GAGTT(C/T)GAGAC downstream-variant-500B

Variation tolerance for COLCA2 Gene

Gene Damage Index Score: 0.50; 10.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COLCA2 Gene

HapMap Linkage Disequilibrium report
COLCA2
Human Gene Mutation Database (HGMD)
COLCA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for COLCA2 Gene

Disorders for COLCA2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for COLCA2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
colorectal cancer
  • colorectal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for COLCA2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COLCA2
genes like me logo Genes that share disorders with COLCA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for COLCA2 Gene

Publications for COLCA2 Gene

  1. Identification of genes expressed by immune cells of the colon that are regulated by colorectal cancer-associated variants. (PMID: 24154973) Peltekova V.D. … Hudson T.J. (Int. J. Cancer 2013) 3 4 67
  2. Generalizability and epidemiologic characterization of eleven colorectal cancer GWAS hits in multiple populations. (PMID: 21071539) He J. … Haiman C.A. (Cancer Epidemiol. Biomarkers Prev. 2011) 2 3
  3. Genetic association of PLCE1, C11orf92-C11orf93, and NOC3L with colorectal cancer risk in the Han population. (PMID: 24146276) Duan X. … Chen C. (Tumour Biol. 2014) 3
  4. Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. (PMID: 24836286) Zhang B. … Zheng W. (Nat. Genet. 2014) 3
  5. Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. (PMID: 23266556) Peters U. … Hsu L. (Gastroenterology 2013) 3

Products for COLCA2 Gene

Sources for COLCA2 Gene

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