Free for academic non-profit institutions. Other users need a Commercial license

Aliases for COLCA2 Gene

Aliases for COLCA2 Gene

  • Colorectal Cancer Associated 2 2 3 5
  • Cancer Susceptibility Candidate Protein 13 3 4
  • Cancer Susceptibility Candidate 13 2 3
  • C11orf93 3 4
  • CASC13 3 4
  • Colorectal Cancer-Associated Protein 2 3
  • Chromosome 11 Open Reading Frame 93 2
  • Colorectal Cancer Associated Two 3
  • LOH11CR1G 3

External Ids for COLCA2 Gene

Previous HGNC Symbols for COLCA2 Gene

  • C11orf93

Previous GeneCards Identifiers for COLCA2 Gene

  • GC11P111170

Summaries for COLCA2 Gene

GeneCards Summary for COLCA2 Gene

COLCA2 (Colorectal Cancer Associated 2) is a Protein Coding gene. Diseases associated with COLCA2 include Colorectal Cancer.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COLCA2 Gene

Genomics for COLCA2 Gene

Regulatory Elements for COLCA2 Gene

Enhancers for COLCA2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G111357 1.6 FANTOM5 ENCODE dbSUPER 26.7 +66.4 66359 15.7 HDGF PKNOX1 FOXA2 MLX ZFP64 WRNIP1 ARID4B DMAP1 YBX1 FEZF1 COLCA2 COLCA1 LAYN C11orf88 MIR34C MIR34B BTG4 POU2AF1 MIR4491 RNU2-60P
GH11G111298 1.1 ENCODE dbSUPER 27 +1.2 1198 2.5 ELF3 FUS ZFP64 ZNF48 RAD21 RARA ZNF143 PCBP1 THAP11 GATAD2B COLCA2 C11orf53 COLCA1
GH11G111302 1 ENCODE dbSUPER 25.3 +4.6 4603 1.7 ELF3 CTCF HLF MAX RAD21 RARA YY1 OSR2 JUND GATA3 COLCA2 C11orf53 COLCA1
GH11G111375 1.4 Ensembl ENCODE dbSUPER 17.5 +79.9 79941 5.1 HDGF TBP PKNOX1 ZNF133 WRNIP1 BMI1 ZBTB40 EGR1 ZNF143 ZNF207 COLCA1 COLCA2 LOC644277 POU2AF1 MIR34C MIR34B BTG4 C11orf88 RNU2-60P MIR4491
GH11G111282 0.8 ENCODE 27 -15.5 -15536 1.0 HDGF CTCF ZNF2 RAD21 TEAD3 ZNF143 SMC3 NR2F6 MIXL1 GATAD2A COLCA2 C11orf53
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around COLCA2 on UCSC Golden Path with GeneCards custom track

Promoters for COLCA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000044820 654 1201 ELF3 FUS ZFP64 ZNF48 RAD21 RARA ZNF143 PCBP1 THAP11 GATAD2B

Genomic Location for COLCA2 Gene

Chromosome:
11
Start:
111,298,546 bp from pter
End:
111,308,735 bp from pter
Size:
10,190 bases
Orientation:
Plus strand

Genomic View for COLCA2 Gene

Genes around COLCA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COLCA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COLCA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COLCA2 Gene

Proteins for COLCA2 Gene

  • Protein details for COLCA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8K830-COLC2_HUMAN
    Recommended name:
    Colorectal cancer-associated protein 2
    Protein Accession:
    A8K830
    Secondary Accessions:
    • E9PMJ8
    • Q2TBJ3
    • V5LD62
    • V5LDI3
    • V5LDV1
    • V5LE09
    • V5LEU3

    Protein attributes for COLCA2 Gene

    Size:
    154 amino acids
    Molecular mass:
    16850 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI10080.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AP002448; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for COLCA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COLCA2 Gene

Post-translational modifications for COLCA2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for COLCA2 Gene

Domains & Families for COLCA2 Gene

Protein Domains for COLCA2 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with COLCA2: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for COLCA2 Gene

Function for COLCA2 Gene

genes like me logo Genes that share phenotypes with COLCA2: view

Animal Models for COLCA2 Gene

MGI Knock Outs for COLCA2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for COLCA2 Gene

Localization for COLCA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COLCA2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for COLCA2 gene
Compartment Confidence
extracellular 2
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for COLCA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 24154973
genes like me logo Genes that share ontologies with COLCA2: view

Pathways & Interactions for COLCA2 Gene

SuperPathways for COLCA2 Gene

No Data Available

Interacting Proteins for COLCA2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000381115%0d%0a9606.ENSP00000200135%0d%0a
Selected Interacting proteins: ENSP00000381115 for COLCA2 Gene via STRING

Symbol External ID(s) Details
ZW10

Gene Ontology (GO) - Biological Process for COLCA2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for COLCA2 Gene

Transcripts for COLCA2 Gene

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COLCA2 Gene

No ASD Table

Relevant External Links for COLCA2 Gene

GeneLoc Exon Structure for
COLCA2
ECgene alternative splicing isoforms for
COLCA2

Expression for COLCA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for COLCA2 Gene

NURSA nuclear receptor signaling pathways regulating expression of COLCA2 Gene:

COLCA2

mRNA Expression by UniProt/SwissProt for COLCA2 Gene:

A8K830-COLC2_HUMAN
Tissue specificity: Expressed in many cell types of epithelial, mesenchymal and hematopoietic origins.

Evidence on tissue expression from TISSUES for COLCA2 Gene

  • Intestine(4.3)
genes like me logo Genes that share expression patterns with COLCA2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for COLCA2 Gene

Orthologs for COLCA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for COLCA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COLCA2 34 35
  • 99.47 (n)
dog
(Canis familiaris)
Mammalia COLCA2 34 35
  • 84.46 (n)
cow
(Bos Taurus)
Mammalia LOC100294918 34
  • 83 (n)
mouse
(Mus musculus)
Mammalia Gm684 34 35
  • 78.34 (n)
Colca2 16
rat
(Rattus norvegicus)
Mammalia RGD1563866 34
  • 77.73 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia COLCA2 35
  • 27 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC101751781 34
  • 57.81 (n)
COLCA2 35
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COLCA2 35
  • 21 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734888 34
  • 52.95 (n)
Species where no ortholog for COLCA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for COLCA2 Gene

ENSEMBL:
Gene Tree for COLCA2 (if available)
TreeFam:
Gene Tree for COLCA2 (if available)

Paralogs for COLCA2 Gene

No data available for Paralogs for COLCA2 Gene

Variants for COLCA2 Gene

Sequence variations from dbSNP and Humsavar for COLCA2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000366266 -- 111,306,061(+) GGTAG(A/G)GGCTG intron-variant, upstream-variant-2KB
rs1000914326 -- 111,305,993(+) GCATC(A/G)GAAGT intron-variant, upstream-variant-2KB
rs1001133494 -- 111,299,373(+) CCGGA(C/G)TCCTG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001245819 -- 111,305,511(+) AGTTT(A/C)AGGAG intron-variant, upstream-variant-2KB
rs1001263073 -- 111,305,558(+) CCACT(-/AA)ATGTG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for COLCA2 Gene

Variant ID Type Subtype PubMed ID
esv3627734 CNV gain 21293372

Variation tolerance for COLCA2 Gene

Gene Damage Index Score: 0.50; 10.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COLCA2 Gene

Human Gene Mutation Database (HGMD)
COLCA2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
COLCA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COLCA2 Gene

Disorders for COLCA2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for COLCA2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
colorectal cancer
  • colorectal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for COLCA2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COLCA2
genes like me logo Genes that share disorders with COLCA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for COLCA2 Gene

Publications for COLCA2 Gene

  1. Identification of genes expressed by immune cells of the colon that are regulated by colorectal cancer-associated variants. (PMID: 24154973) Peltekova V.D. … Hudson T.J. (Int. J. Cancer 2013) 3 4 64
  2. Generalizability and epidemiologic characterization of eleven colorectal cancer GWAS hits in multiple populations. (PMID: 21071539) He J. … Haiman C.A. (Cancer Epidemiol. Biomarkers Prev. 2011) 2 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Genetic association of PLCE1, C11orf92-C11orf93, and NOC3L with colorectal cancer risk in the Han population. (PMID: 24146276) Duan X. … Chen C. (Tumour Biol. 2014) 3 64

Products for COLCA2 Gene

Sources for COLCA2 Gene

Content
Loading form....