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COL6A6 Gene

protein-coding   GIFtS: 43
GCID: GC03P130280

Collagen, Type VI, Alpha 6

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Collagen, Type VI, Alpha 61 2
Collagen Alpha-6(VI) Chain2

External Ids:    HGNC: 270231   Entrez Gene: 1318732   Ensembl: ENSG000002063847   UniProtKB: A6NMZ73   

Export aliases for COL6A6 gene to outside databases

Previous GC identifers: GC03P131715 GC03P127663


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for COL6A6 Gene:
COL6A6 (collagen, type VI, alpha 6) is a protein-coding gene. An important paralog of this gene is COL28A1.

UniProtKB/Swiss-Prot: CO6A6_HUMAN, A6NMZ7
Function: Collagen VI acts as a cell-binding protein (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the COL6A6 gene promoter:
         AREB6   NF-AT4   NF-AT2   FOXJ2 (long isoform)   NF-AT3   FOXJ2   Tal-1beta   NF-AT1   NF-AT   E47   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for COL6A6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COL6A6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22.1   Ensembl cytogenetic band:  3q22.1   HGNC cytogenetic band: 3q22.1

COL6A6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COL6A6 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P130280:  view genomic region     (about GC identifiers)

Start:
130,279,178 bp from pter      End:
130,396,999 bp from pter
Size:
117,822 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CO6A6_HUMAN, A6NMZ7 (See protein sequence)
Recommended Name: Collagen alpha-6(VI) chain precursor  
Size: 2263 amino acids; 247173 Da
Subunit: Trimers composed of three different chains: alpha-1(VI), alpha-2(VI), and alpha-3(VI) or alpha-5(VI) or
alpha-6(VI) (Probable)
Secondary accessions: A7DZQ0 A7DZQ1 A7DZQ2 Q69YT0
Alternative splicing: 2 isoforms:  A6NMZ7-1   A6NMZ7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for COL6A6: NX_A6NMZ7

Explore proteomics data for COL6A6 at MOPED

Post-translational modifications: 

  • Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the
    chains (By similarity)1
  • Glycosylation2 at Asn198, Asn275, Asn288, Asn347, Asn520, Asn930, Asn988, Asn1290, Asn2034
  • Modification sites at PhosphoSitePlus

  • See COL6A6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001096078.1  
    ENSEMBL proteins: 
     ENSP00000351310   ENSP00000426006   ENSP00000422921   ENSP00000399236  
    Reactome Protein details: A6NMZ7

    COL6A6 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for COL6A6
    GenScript Custom Purified and Recombinant Proteins Services for COL6A6
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for COL6A6 

     
    Search antibodies-online for proteins for COL6A6 

     
    Search antibodies-online for peptides for COL6A6

    COL6A6 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    OriGene Custom Antibody Services for COL6A6
    Novus Biologicals COL6A6 Antibody
    Abcam antibodies for COL6A6
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for COL6A6
    Search antibodies-online for antibodies for COL6A6 

    COL6A6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for COL6A6
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for COL6A6 
    antibodies-online kits for COL6A6 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    COLLAGEN: Collagens

    2 InterPro protein domains:
     IPR008160 Collagen
     IPR002035 VWF_A

    Graphical View of Domain Structure for InterPro Entry A6NMZ7

    ProtoNet protein and cluster: A6NMZ7

    UniProtKB/Swiss-Prot: CO6A6_HUMAN, A6NMZ7
    Similarity: Belongs to the type VI collagen family
    Similarity: Contains 9 VWFA domains


    Find genes that share domains with COL6A6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CO6A6_HUMAN, A6NMZ7
    Function: Collagen VI acts as a cell-binding protein (By similarity)

    Animal Models:

       genOway: Develop your customized and physiologically relevant rodent model for COL6A6

    miRNA
    Products:
        
    miRTarBase miRNAs that target COL6A6:
    hsa-mir-335-5p (MIRT018435)

    Block miRNA regulation of human, mouse, rat COL6A6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate COL6A6 (see all 15):
    hsa-miR-4268 hsa-miR-509-5p hsa-miR-29a hsa-miR-29c hsa-miR-516b* hsa-miR-486-5p hsa-miR-1305 hsa-miR-942
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat COL6A6

    Gene Editing
    Products:
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    Clone
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    OriGene clones in human, mouse for COL6A6 (see all 5)
    OriGene ORF clones in mouse, rat for COL6A6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: COL6A6 (NM_001102608)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COL6A6
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat COL6A6

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COL6A6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CO6A6_HUMAN, A6NMZ7: Secreted, extracellular space, extracellular matrix (By similarity). Note=Deposed in the
    extracellular matrix of skeletal muscle (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    endoplasmic reticulum3
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005581collagen IEA--
    GO:0031012extracellular matrix IDA18400749

    Find genes that share ontologies with COL6A6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for COL6A6 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Collagen biosynthesis and modifying enzymes
    Collagen biosynthesis and modifying enzymes0.75
    Assembly of collagen fibrils and other multimeric structures0.62
    Collagen formation0.75
    2Focal adhesion
    Focal adhesion0.65
    ECM-receptor interaction0.31
    3L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    4NCAM signaling for neurite out-growth
    NCAM1 interactions0.59
    NCAM signaling for neurite out-growth0.59
    5Signaling by FGFR
    Signaling by PDGF0.87


    Find genes that share SuperPaths with COL6A6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected Reactome Pathways for COL6A6 (see all 7)
        ECM proteoglycans
    Integrin cell surface interactions
    NCAM1 interactions
    Collagen biosynthesis and modifying enzymes
    Assembly of collagen fibrils and other multimeric structures


    4 Kegg Pathways  (Kegg details for COL6A6):
        PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Protein digestion and absorption

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for COL6A6
    Interactions:

        Search GeneGlobe Interaction Network for COL6A6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for COL6A6 (ENSP000003513104) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD44ENSP000002783854STRING: ENSP00000278385
    GP6ENSP000003087824STRING: ENSP00000308782
    ITGA1ENSP000002825884STRING: ENSP00000282588
    ITGA10ENSP000003583104STRING: ENSP00000358310
    ITGA11ENSP000003272904STRING: ENSP00000327290
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    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0022617extracellular matrix disassembly TAS--
    GO:0030198extracellular matrix organization TAS--
    GO:0030574collagen catabolic process TAS--

    Find genes that share ontologies with COL6A6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for COL6A6 (CO6A6)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for COL6A6 gene: 
    NM_001102608.1  

    Unigene Cluster for COL6A6:

    Collagen, type VI, alpha 6
    Hs.591282  [show with all ESTs]
    Unigene Representative Sequence: NM_001102608
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000358511(uc010htl.3) ENST00000506143(uc003eni.4) ENST00000511332
    ENST00000453409
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat COL6A6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate COL6A6 (see all 15):
    hsa-miR-4268 hsa-miR-509-5p hsa-miR-29a hsa-miR-29c hsa-miR-516b* hsa-miR-486-5p hsa-miR-1305 hsa-miR-942
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for COL6A6
    Predesigned siRNA for gene silencing in human, mouse, rat COL6A6
    Clone
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    OriGene clones in human, mouse for COL6A6 (see all 5)
    OriGene ORF clones in mouse, rat for COL6A6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: COL6A6 (NM_001102608)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COL6A6
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat COL6A6
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for COL6A6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat COL6A6
      QuantiTect SYBR Green Assays in human, mouse, rat COL6A6
      QuantiFast Probe-based Assays in human, mouse, rat COL6A6

    Additional mRNA sequence: 

    AL713792.1 AM774225.1 AM774226.1 AM774227.1 

    2 DOTS entries:

    DT.305267  DT.120887179 

    Selected AceView cDNA sequences (see all 43):

    BU742024 AW274710 N22966 AA478634 N22964 AA449944 H88506 AF086237 
    AI378321 N32379 BM725130 AL713792 BM725094 AA912545 BU741991 AA772045 
    AI337483 AA455864 AI079805 AI742521 BM091491 BF061458 AI051463 AI141346 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    COL6A6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    COL6A6 Expression
    About this image

    COL6A6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    COL6A6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591282
        Custom PCR Arrays for COL6A6
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat COL6A6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COL6A6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for COL6A6 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Col6a61 , 5 collagen, type VI, alpha 61, 5 83.03(n)1
    83.47(a)1
      9 (56.99 cM)5
    2450261  NM_001102607.11  NP_001096077.11 
     1056894175 
    chicken
    (Gallus gallus)
    Aves COL6A61 collagen, type VI, alpha 6 51.86(n)
    40.88(a)
      428448  XM_426008.4  XP_426008.4 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    50(a)
    many ↔ many
    6(36945116-37036184)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004860631 collagen alpha-6(VI) chain-like 52.3(n)
    42.96(a)
      100486063  XM_002942359.2  XP_002942405.2 
    zebrafish
    (Danio rerio)
    Actinopterygii col6a61 collagen, type VI, alpha 6 49.18(n)
    37.13(a)
      564005  XM_687365.6  XP_692457.6 


    ENSEMBL Gene Tree for COL6A6 (if available)
    TreeFam Gene Tree for COL6A6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for COL6A6 gene
    COL28A12  COL6A12  COLEC122  COL6A52  COLQ2  COL6A22  SCARA32  COL17A12  
    COL6A32  
    14 SIMAP similar genes for COL6A6 using alignment to 4 protein entries:     CO6A6_HUMAN (see all proteins):
    COL6A5    COCH    VIT    MSR1    DKFZp686K04147    ITGA2
    COL6A3    COL21A1    COLQ    COL3A1    COLEC11    C1QTNF9
    C1QTNF9B    COL13A1

    Find genes that share paralogs with COL6A6           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for COL6A6
    PGOHUM00000237544 PGOHUM00000238185


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for COL6A6 (see all 2491)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs21749441,2
    C,F,O,A,H--130277221(+) CTTCAC/TCGGGC 1 -- us2k1110Minor allele frequency- T:0.45NS NA EA PA EU CA WA CSA 6852
    rs731980211,2
    C--130277223(+) TCACCA/GGGCTT 1 -- us2k10--------
    rs1154203341,2
    F--130277663(+) TTAGTT/GCTTAG 1 -- us2k11Minor allele frequency- G:0.06WA 118
    rs778695741,2
    C,F--130278086(+) ATGAAA/GAGGTT 1 -- us2k11Minor allele frequency- G:0.06WA 118
    rs780698911,2
    F--130278096(+) TTGTAC/TTACAC 1 -- us2k11Minor allele frequency- T:0.07EA 120
    rs68085831,2
    C,F,H--130278105(+) ACATTA/GCCTCC 1 -- us2k119Minor allele frequency- G:0.27NA NS EA WA CSA 914
    rs1905645731,2
    --130278245(+) GGACAC/GTGATG 1 -- us2k10--------
    rs1123785661,2
    C,F--130278292(+) ATGTCC/TCTTTT 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1153492531,2
    C,F--130278304(+) TGAAGA/GGATTG 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs729922771,2
    C,F--130278358(+) CATATA/GTAGTG 1 -- us2k13Minor allele frequency- G:0.22WA CSA 121

    HapMap Linkage Disequilibrium report for COL6A6 (130279178 - 130396999 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for COL6A6 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2725915CNV Deletion23290073
    esv2450346CNV Deletion19546169
    dgv83n16CNV Deletion17901297
    esv4329CNV Deletion18987735
    esv2271871CNV Deletion18987734
    esv2725914CNV Deletion23290073
    nsv4003CNV Insertion18451855
    nsv4005CNV Insertion18451855
    nsv508243CNV Loss20534489
    nsv521211CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing COL6A6
    DNA2.0 Custom Variant and Variant Library Synthesis for COL6A6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for COL6A6 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with COL6A6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Three novel collagen VI chains with high homology to the alpha 3 chain. (PubMed id 18276594)1, 2 Gara S.K.... Wagener R. (J. Biol. Chem. 2008)
    2. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)1, 2 Muzny D.M....Gibbs R.A. (Nature 2006)
    3. Expression of collagen VI I+5 and I+6 chains in human muscle and in Duchenne muscular dystrophy-related muscle fibrosis. (PubMed id 22226732)1 Sabatelli P....Wagener R. (Matrix Biol. 2012)
    4. Expression of the collagen VI I+5 and I+6 chains in normal human skin and in skin of patients with collagen VI-related myopathies. (PubMed id 20882040)1 Sabatelli P....Wagener R. (J. Invest. Dermatol. 2011)
    5. Collagen VI is a basement membrane component that regulates epithelial cell-fibronectin interactions. (PubMed id 21406227)1 Groulx J.F....Beaulieu J.F. (Matrix Biol. 2011)
    6. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (J. Proteome Res. 2009)
    7. Three novel collagen VI chains, alpha4(VI), alpha5(VI), and alpha6(VI). (PubMed id 18400749)1 Fitzgerald J....Hansen U. (J. Biol. Chem. 2008)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 131873 HGNC: 27023 AceView: LOC131873 Ensembl:ENSG00000206384 euGenes: HUgn131873
    ECgene: COL6A6 Kegg: 131873 H-InvDB: COL6A6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for COL6A6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for COL6A6 gene:
    Search GeneIP for patents involving COL6A6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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