Aliases for COL6A2 Gene
Aliases for COL6A2 Gene
External Ids for COL6A2 Gene
- HGNC: 2212
- Entrez Gene: 1292
- Ensembl: ENSG00000142173
- OMIM: 120240
- UniProtKB: P12110
Previous GeneCards Identifiers for COL6A2 Gene
- GC21P044024
- GC21P046374
- GC21P046342
- GC21P047518
- GC21P032899
Summaries for COL6A2 Gene
-
This gene encodes one of the three alpha chains of type VI collagen, a beaded filament collagen found in most connective tissues. The product of this gene contains several domains similar to von Willebrand Factor type A domains. These domains have been shown to bind extracellular matrix proteins, an interaction that explains the importance of this collagen in organizing matrix components. Mutations in this gene are associated with Bethlem myopathy and Ullrich scleroatonic muscular dystrophy. Three transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for COL6A2 Gene
COL6A2 (Collagen Type VI Alpha 2 Chain) is a Protein Coding gene. Diseases associated with COL6A2 include Ullrich Congenital Muscular Dystrophy 1 and Myosclerosis, Congenital. Among its related pathways are Collagen chain trimerization and Phospholipase-C Pathway. An important paralog of this gene is COL6A1.
UniProtKB/Swiss-Prot for COL6A2 Gene
-
Collagen VI acts as a cell-binding protein.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COL6A2 Gene
Genomics for COL6A2 Gene
Regulatory Elements for COL6A2 Gene
Enhancers for COL6A2 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around COL6A2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for COL6A2 Gene
- Chromosome:
- 21
- Start:
- 46,097,606 bp from pter
- End:
- 46,132,849 bp from pter
- Size:
- 35,244 bases
- Orientation:
- Plus strand
Genomic View for COL6A2 Gene
Genes around COL6A2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 21q22.3 by Ensembl
- 21q22.3 by Entrez Gene
- 21q22.3 by HGNC
COL6A2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for COL6A2 Gene
Proteins for COL6A2 Gene
-
Protein details for COL6A2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P12110-CO6A2_HUMAN
- Recommended name:
- Collagen alpha-2(VI) chain
- Protein Accession:
- P12110
- Q13909
- Q13910
- Q13911
- Q14048
- Q14049
- Q16259
- Q16597
- Q6P0Q1
- Q9UML3
- Q9Y4S8
Protein attributes for COL6A2 Gene
- Size:
- 1019 amino acids
- Molecular mass:
- 108579 Da
- Quaternary structure:
-
- Trimers composed of three different chains: alpha-1(VI), alpha-2(VI), and alpha-3(VI) or alpha-5(VI) or alpha-6(VI). Interacts with CSPG4.
Protein Expression for COL6A2 Gene
Post-translational modifications for COL6A2 Gene
- Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
- Glycosylation at Asn140, Asn327, posLast=630630, posLast=785785, Asn897, and Asn954
- Modification sites at PhosphoSitePlus
Other Protein References for COL6A2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for COL6A2
- Novus Biologicals Antibodies for COL6A2
-
Abcam antibodies for COL6A2
- Invitrogen Antibodies for COL6A2
- antibodies-online Antibodies for COL6A2: See all 37
- GeneTex COL6A2 antibody for COL6A2
-
Santa Cruz Biotechnology (SCBT) Antibodies for COL6A2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for COL6A2
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- Search GeneTex for Proteins for COL6A2
-
Abcam proteins for COL6A2
Assay Products
- antibodies-online Kits for COL6A2: See all 11
No data available for DME Specific Peptides for COL6A2 Gene
Domains & Families for COL6A2 Gene
Gene Families for COL6A2 Gene
- HGNC:
Protein Domains for COL6A2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for COL6A2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P12110- Family:
-
- Belongs to the type VI collagen family.
Function for COL6A2 Gene
Molecular function for COL6A2 Gene
- GENATLAS Biochemistry:
- collagen type VI,alpha 2 (140kDa),microfibrillar
- UniProtKB/Swiss-Prot Function:
- Collagen VI acts as a cell-binding protein.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 12812986 |
Phenotypes for COL6A2 Gene
- MGI mutant phenotypes for COL6A2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for COL6A2:
Animal Models for COL6A2 Gene
- MGI Knock Outs for COL6A2:
-
- Col6a2 tm1.1(KOMP)Vlcg
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for COL6A2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for COL6A2 gene
- Search ViGene Biosciences for COL6A2
CRISPR Products
-
OriGene CRISPR knockouts for COL6A2
-
Santa Cruz Biotechnology (SCBT) CRISPR for COL6A2
- GenScript: Design CRISPR guide RNA sequences for COL6A2
miRNA for COL6A2 Gene
- miRTarBase miRNAs that target COL6A2
miRNA Products
- Search ViGene Biosciences for COL6A2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for COL6A2
- Browse OriGene Inhibitory RNA Products For COL6A2
-
ViGene Biosciences ready-to-package AAV shRNAs for COL6A2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for COL6A2
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
- ESI BIO PureStem E15, Meso-prx/latp Progenitor and PureStem SK11, NCr-fac & Meso-prx Progenitor for COL6A2
-
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-
ViGene Biosciences adenoviral particle packaged cDNA for COL6A2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for COL6A2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for COL6A2 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for COL6A2 Gene
Localization for COL6A2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for COL6A2 Gene
- Secreted, extracellular space, extracellular matrix. Membrane; Peripheral membrane protein. Note=Recruited on membranes by CSPG4.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| endoplasmic reticulum | 5 |
| plasma membrane | 3 |
| cytosol | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005578 | proteinaceous extracellular matrix | IEA | -- |
| GO:0005581 | collagen trimer | IEA | -- |
| GO:0005615 | extracellular space | IDA | 20551380 |
| GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
Pathways & Interactions for COL6A2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Collagen chain trimerization | ||
| 2 | Integrin Pathway |
.67
.67
.56
|
.56
|
| 3 | ERK Signaling |
.61
.58
|
.49
|
| 4 | Focal Adhesion |
.62
|
.62
|
| 5 | Phospholipase-C Pathway |
.56
|
|
Pathways by source for COL6A2 Gene
2 BioSystems pathways for COL6A2 Gene
11 Reactome pathways for COL6A2 Gene
4 KEGG pathways for COL6A2 Gene
15 Qiagen pathways for COL6A2 Gene
Interacting Proteins for COL6A2 Gene
Selected Interacting proteins:
ENSP00000300527
P12110-CO6A2_HUMAN
for COL6A2 Gene via
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007155 | cell adhesion | IEA | -- |
| GO:0009749 | response to glucose | IEA | -- |
| GO:0030198 | extracellular matrix organization | TAS | -- |
| GO:0030574 | collagen catabolic process | TAS | -- |
| GO:0070208 | protein heterotrimerization | IPI | 18400749 |
No data available for SIGNOR curated interactions for COL6A2 Gene
Transcripts for COL6A2 Gene
mRNA/cDNA for COL6A2 Gene
- (4) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (1040) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for COL6A2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for COL6A2
-
Santa Cruz Biotechnology (SCBT) CRISPR for COL6A2
- GenScript: Design CRISPR guide RNA sequences for COL6A2
miRNA Products
- Search ViGene Biosciences for COL6A2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for COL6A2
- Browse OriGene Inhibitory RNA Products For COL6A2
-
ViGene Biosciences ready-to-package AAV shRNAs for COL6A2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for COL6A2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for COL6A2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - |
| ExUns: | 26a | · | 26b | ^ | 27 |
|---|---|---|---|---|---|
| SP1: | |||||
| SP2: | |||||
| SP3: | |||||
| SP4: | |||||
| SP5: | |||||
| SP6: | |||||
| SP7: | |||||
| SP8: |
Expression for COL6A2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Cartilage (Muscoskeletal System)
- Intervertebral Disc Annulus Fibrosus Cells Annulus Fibrosus
- Lateral Plate Mesoderm (Gastrulation Derivatives)
- Paraxial Mesoderm (Gastrulation Derivatives)
This gene is overexpressed in Adipocyte (15.2), Urinary Bladder (9.7), Bone marrow mesenchymal stem cell (8.6), Colon muscle (8.5), and Gallbladder (6.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for COL6A2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of COL6A2 Gene:
COL6A2SOURCE GeneReport for Unigene cluster for COL6A2 Gene:
Hs.420269Evidence on tissue expression from TISSUES for COL6A2 Gene
- Lung(4.7)
- Liver(4.3)
- Bone(4.2)
- Skin(3.9)
- Nervous system(3.8)
- Eye(3.4)
- Heart(3.1)
- Intestine(3.1)
- Muscle(3.1)
- Pancreas(2.9)
- Gall bladder(2.3)
Phenotype-based relationships between genes and organs from Gene ORGANizer for COL6A2 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- integumentary
- nervous
- respiratory
- skeletal muscle
- skeleton
- urinary
Organs:
Head and neck:
- brain
- cheek
- chin
- cranial nerve
- ear
- face
- head
- jaw
- mandible
- maxilla
- mouth
- neck
- outer ear
- skull
Thorax:
- bronchus
- chest wall
- clavicle
- diaphragm
- heart
- lung
- rib
- rib cage
- scapula
- sternum
Abdomen:
- kidney
Pelvis:
- pelvis
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- blood
- blood vessel
- peripheral nerve
- peripheral nervous system
- skin
- spinal column
- spinal cord
- sweat gland
- vertebrae
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for COL6A2
No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for COL6A2 Gene
Orthologs for COL6A2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | COL6A2 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | COL6A2 35 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Col6a2 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Col6a2 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | COL6A2 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | COL6A2 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | COL6A2 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100145523 34 |
|
||
| Str.15727 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | col6a2 34 35 |
|
||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.2562 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | mec-5 35 |
|
OneToMany |
- Species where no ortholog for COL6A2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for COL6A2 Gene
(14) SIMAP similar genes for COL6A2 Gene using alignment to 4 proteins:
Variants for COL6A2 Gene
| SNP ID | Clin | Chr 21 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs117725825 | Pathogenic, Bethlem myopathy 1 (BTHLM1) [MIM:158810] | 46,132,287(+) | CAGCC(C/T)GCGTG | nc-transcript-variant, reference, missense | |
| rs121912940 | Pathogenic, Bethlem myopathy 1 (BTHLM1) [MIM:158810] | 46,115,881(+) | CCAAG(A/G)GCAAC | nc-transcript-variant, reference, missense | |
| rs267606747 | Pathogenic, Bethlem myopathy 1 (BTHLM1) [MIM:158810] | 46,126,144(+) | TCGCC(C/T)GCGAC | nc-transcript-variant, reference, missense | |
| rs267606748 | Pathogenic, Ullrich congenital muscular dystrophy 1 (UCMD1) [MIM:254090] | 46,115,917(+) | AGAAG(A/G)GAAGA | nc-transcript-variant, reference, missense | |
| rs267606749 | Pathogenic, Ullrich congenital muscular dystrophy 1 (UCMD1) [MIM:254090] | 46,121,590(+) | ACCCC(A/G)TGGAG | nc-transcript-variant, reference, missense |
Residual Variation Intolerance Score:
89% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
15.65;
97.28% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for COL6A2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COL6A2 Gene
Disorders for COL6A2 Gene
(11) MalaCards diseases for COL6A2 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ullrich congenital muscular dystrophy 1 |
|
|
| myosclerosis, congenital |
|
|
| bethlem myopathy 1 |
|
|
| collagen type vi-related disorders |
|
|
| autosomal recessive myosclerosis myopathy |
|
|
Search COL6A2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
CO6A2_HUMAN- Bethlem myopathy 1 (BTHLM1) [MIM:158810]: A benign proximal myopathy characterized by early childhood onset and joint contractures most frequently affecting the elbows and ankles. {ECO:0000269 PubMed:11865138, ECO:0000269 PubMed:15689448, ECO:0000269 PubMed:17886299, ECO:0000269 PubMed:8782832}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Myosclerosis autosomal recessive (MYOSAR) [MIM:255600]: A condition characterized by chronic inflammation of skeletal muscle with hyperplasia of the interstitial connective tissue. The clinical picture includes slender muscles with firm woody consistency and restriction of movement of many joints because of muscle contractures. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Ullrich congenital muscular dystrophy 1 (UCMD1) [MIM:254090]: A congenital myopathy characterized by muscle weakness and multiple joint contractures, generally noted at birth or early infancy. The clinical course is more severe than in Bethlem myopathy. {ECO:0000269 PubMed:15563506, ECO:0000269 PubMed:15689448}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for COL6A2
No data available for Genatlas for COL6A2 Gene
Publications for COL6A2 Gene
- Dominant collagen VI mutations are a common cause of Ullrich congenital muscular dystrophy. (PMID: 15563506) Baker N.L. … Lamande S.R. (Hum. Mol. Genet. 2005) 3 4 22 64
- The expanded collagen VI family: new chains and new questions. (PMID: 23869615) Fitzgerald J. … Hansen U. (Connect. Tissue Res. 2013) 2 3 64
- Identification of a deep intronic mutation in the COL6A2 gene by a novel custom oligonucleotide CGH array designed to explore allelic and genetic heterogeneity in collagen VI-related myopathies. (PMID: 20302629) Bovolenta M. … Gualandi F. (BMC Med. Genet. 2010) 3 22 64
- Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PMID: 19204726) Chapuis J. … Lambert J.C. (Mol. Psychiatry 2009) 3 46 64
- Identification and characterization of novel collagen VI non-canonical splicing mutations causing Ullrich congenital muscular dystrophy. (PMID: 19309692) Martoni E. … Gualandi F. (Hum. Mutat. 2009) 3 22 64
Products for COL6A2 Gene
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for COL6A2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer