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COL4A1 Gene

protein-coding GIFtS: 66

GC13M109599

collagen, type IV, alpha 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
Arresten ^³
OTTHUMP00000018698 ^²
arresten ^²

Descriptions
COL4A1 NC1 domain ^²
alpha 1 type IV collagen ^²
collagen IV, alpha-1 polypeptide ^²
collagen of basement membrane, alpha-1 chain ^²
collagen, type IV, alpha 1 ^²

External Ids
HGNC: 2202¹
Entrez Gene: 1282²
UniProtKB: P02462³
Ensembl: ENSG00000187498⁷

Search outside databases for aliases for COL4A1 gene

Previous GC identifers: GC13M109161 GC13M105188 GC13M109638 GC13M108499

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for COL4A1:

This gene encodes the major type IV alpha collagen chain of basement membranes. Like the other

members of the type IV collagen gene family, this gene is organized in a head-to-head conformation

with another type IV collagen gene so that each gene pair shares a common promoter. [provided by

RefSeq]

UniProtKB/Swiss-Prot: CO4A1_HUMAN, P02462

Function: Type IV collagen is the major structural component of glomerular basement membranes

(GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and

entactin/nidogen. Potently inhibits endothelial cell proliferation and angiogenesis. Inhibits

angiogenesis potentially via mechanisms involving cell surface proteoglycans and the alpha and

beta integrins of endothelial cells

Gene Wiki entry for COL4A1 (Collagen%2C_type_IV%2C_alpha_1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the COL4A1 gene

Entrez Gene cytogenetic band: 13q34 Ensembl cytogenetic band: 13q34 HGNC cytogenetic band: 13q34

COL4A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13M109599: (about GC identifiers)

Start:	109,599,311 bp from pter
End:	109,757,497 bp from pter
Size:	158,187 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000013.9 NT_009952.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CO4A1_HUMAN, P02462 (See protein sequence)

Recommended Name: Collagen alpha-1(IV) chain precursor

Size: 1669 amino acids; 160615 Da

Subunit: There are six type IV collagen isoforms, alpha 1(IV)-alpha 6(IV), each of which can form a

triple helix structure with 2 other chains to generate type IV collagen network

Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane

PDB structures from and Proteopedia :

1LI1 (3D)

Secondary accessions: A7E2W4 B1AM70 Q1P9S9 Q5VWF6 Q86X41 Q8NF88 Q9NYC5

Alternative splicing: 2 isoforms: P02462-1 P02462-2

Post-translational modifications:

Lysines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in all

cases and bind carbohydrates¹

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or

all of the chains¹

Type IV collagens contain numerous cysteine residues which are involved in inter- and

intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all

known type IV collagens¹

The trimeric structure of the NC1 domains may be stabilized by covalent bonds between Lys and Met

residues¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001836.2

ENSEMBL proteins:

ENSP00000380382 ENSP00000364973 ENSP00000354105 ENSP00000364979

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant COL4A1 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Collagen IV, Collagen I + II + III + IV + V)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	14718574
GO:0005581	collagen	IEA	--
GO:0005587	collagen type IV	IEA	--

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Antibodies for COL4A1:

	Invitrogen Antibodies for COL4A1
	Millipore Mono- and Polyclonal Antibodies for the study of COL4A1
	Sigma-Aldrich Antibody Arrays and Antibodies for COL4A1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Collagen IV, Collagen I + II + III + IV + V), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (COL4A1)
	Novus Biologicals Antibodies for COL4A1

Assays for COL4A1:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of COL4A1
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P02462

ProtoNet protein and cluster: P02462

3 Blocks protein families:

IPB001442 Type 4 procollagen

IPB008160 Collagen triple helix repeat

IPB008161 Collagen helix repeat

UniProtKB/Swiss-Prot: CO4A1_HUMAN, P02462

Domain: Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus,

frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may

cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain

Similarity: Belongs to the type IV collagen family

Similarity: Contains 1 collagen IV NC1 (C-terminal non-collagenous) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (COL4A1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001845

Applied Biosystems Silencer® siRNAs for COL4A1

Sigma-Aldrich siRNA for COL4A1

Sigma-Aldrich shRNA Panels and shRNA for COL4A1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001845
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001845
untagged cDNA clone in CMV expression vector: NM_001845

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001845

UniProtKB/Swiss-Prot: CO4A1_HUMAN, P02462

Function: Type IV collagen is the major structural component of glomerular basement membranes

(GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and

entactin/nidogen. Potently inhibits endothelial cell proliferation and angiogenesis. Inhibits

angiogenesis potentially via mechanisms involving cell surface proteoglycans and the alpha and

beta integrins of endothelial cells

Genatlas biochemistry entry for COL4A1:

collagen type IV,alpha 1,basement membrane,all tissues,expressed in the dermoepidermal junction

during fetal skin development

11 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Col4a1):

	embryogenesis	growth/size	hematopoietic system	lethality-postnatal
lethality-prenatal/perinatal	nervous system	other	renal/urinary system	reproductive system
vision/eye

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005201	extracellular matrix structural constituent	IEA	--
GO:0005488	binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/91 Interacting proteins for COL4A1 (ENSP00000364973³ P02462²) via UniProtKB, MINT, and/or STRING (see all 91 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
COCH	O43405²	MINT-6796166
COL16A1	Q07092²	MINT-6743179
COL4A2	ENSP00000353654³	STRING (score=.997)
FN1	ENSP00000323534³	STRING (score=.983)
NID1	ENSP00000264187³	STRING (score=.967)

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for COL4A1
2 Novoseek chemical compound relationships for COL4A1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
arresten	93.58	6	10811134 (4), 18775695 (1), 16151532 (1)
tyrosine	0.00	2	17638901 (1), 9027485 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (COL4A1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001845

Sigma-Aldrich siRNA for COL4A1

Sigma-Aldrich shRNA Panels and shRNA for COL4A1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001845

REFSEQ mRNAs for COL4A1 gene:

NM_001845.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001845

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001845
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001845
                                 untagged cDNA clone in CMV expression vector: NM_001845

Additional cDNA sequence:

AB209646.1 AF258349.1 AF363672.1 AF400431.1 AF536207.1 AY285780.1 BC047305.1 BC142626.1

BC151220.1 CR593711.1 DQ464183.1 EU260121.1 M10940.1 M10941.1 M11315.1 X03963.1

X05561.1 Y00706.1

20 DOTS entries:

DT.452612 DT.100686990 DT.100796397 DT.100796389 DT.95242820 DT.402672 DT.95242796 DT.100796390

DT.100030647 DT.100796398 DT.102838671 DT.121627343 DT.85104942 DT.86855614 DT.95185880 DT.95258962

DT.97784947 DT.99958932 DT.95177824 DT.97809583

24/685 AceView cDNA sequences (see all 685 ):

AF400431 BP338896 AA337576 BQ083525 BI092437 AW273009 CA425542 BG939825

BM712591 AW515625 AI922605 AW014980 AW273358 AW103104 AA678230 W78140

CA447680 BQ084460 AI683543 AA347635 AA114883 AW272975 BQ774173 R22979

highest scoring ESTs for COL4A1:

AA948682 M11315 AL572880 X05561 AA031483 AA031504 AA031550 AA035471 AA037507 AA039800

Unigene Cluster for COL4A1:

Collagen, type IV, alpha 1

Hs.17441 [show with all ESTs]

Unigene Representative Sequence: NM_001845

GeneLoc Exon Structure

4 Ensembl transcripts including schematic representations:

ENST00000397198 ENST00000375815 ENST00000360859 ENST00000375820

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

COL4A1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for COL4A1

¹ / ² / ³

7 probe-sets matching COL4A1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
59548_at²^{, 3}	U95-B	1	1.00	1.00	0.26	0.77	AI732248	0.20	1.00	0.72	1
39333_at²^{, 3}	U95-A	1	1.00	1.00	0.99	1.00	M11315	0.80	1.00	0.91	1
73188_s_at²^{, 3}	U95-E	1	1.00	1.00	0.99	1.24	AA948682	0.80	1.00	0.91	1
211981_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001845	0.60	1.00	0.82	1
211980_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI922605	0.40	1.00	0.76	1
211981_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211980_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks COL4A1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GACCGCAGGA

SOURCE GeneReport for Unigene cluster: Hs.17441
Expression variation in blood from EXPOLDB for COL4A1
UniProtKB/Swiss-Prot: CO4A1_HUMAN, P02462
Tissue specificity: Highly expressed in placenta

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for COL4A1 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	COL4A1¹	--	collagen, type IV, alpha 1	84.12(n) 89.99(a)	403496 XM_534182.2 XP_534182.2
cow (Bos taurus)	COL4A1¹	--	collagen, type IV, alpha 1	83.4(n) 89.75(a)	282191 XM_580317.3 XP_580317.3
rat (Rattus norvegicus)	Col4a1¹	--	collagen, type IV, alpha 1	84.1(n) 90.83(a)	290905 XM_214400.4 XP_214400.3
mouse (Mus musculus)	Col4a1^{1, 5}	8 (5.00 cM)⁵	collagen, type IV, alpha 1^{1, 5}	83.44(n)¹ 90.65(a)¹	12826¹ NM_009931.1¹ NP_034061.1¹ AK142097⁵ AK146487⁵ (see all 34)
chicken (Gallus gallus)	COL4A1¹	--	collagen, type IV, alpha 1	69.84(n) 74.62(a)	395530 XM_416951.2 XP_416951.2

About this table Species with no ortholog for COL4A1

ENSEMBL Gene Tree for COL4A1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for COL4A1 gene

COL4A3² COL22A1² COL4A5²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1420 NCBI SNPs in COL4A1 are shown (see all 1420 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 595)

AB	SNP ID	Valid	Chr 13 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3742207^1,2	A,C,F,H	109616599(-)	`GATCAA/CGGCGT`	1	Q/H	mis¹		17		EA EU WA NA	2944
	rs13260^1,2	A,C,F,H	109600124(+)	`AAATTG/TTGATT`	1	--	ut3¹ ese³		12		MN EU EA WA NA	1164
	rs34843786^1,2	C,F	109655747(+)	`CACCAG/AGAAAA`	1	L/P	mis¹		5		NA EU EA WA	496
	rs536174^1,2	C,H	109637551(-)	`GCATGC/ACAGGG`	1	P/T	mis¹ ese³		5		MN EU EA WA	600
	rs8229^1,2	H	109648931(-)	`TGAAAG/AAGGAG`	1	K/R	mis¹ ese³ trp³		4		EU EA WA	406
--	rs11545878^1,2	H	109612641(+)	`GTAAAG/AAATTT`	1	F/L	mis¹		4		EU EA WA	406
--	rs603749^1,2	C	109599168(+)	`ACAGAG/TGGAAG`	1	--	ng5¹		0	--	--	--	--
	rs532625^1,2	A,C,F,H,O	109662226(+)	`TTTCCA/TGCGAA`	1	A/A	syn¹ ese³		17		EA NA EU WA	1484
	rs874203^1,2	A,C,F,H,O	109625575(+)	`TCACCT/ACGCAG`	1	R/R	syn¹ ese³		4		EU EA WA	412
	rs1133219^1,2	C,F,H	109611710(-)	`ACGGCC/TGGCAG`	1	A/A	syn¹ ese³		4		EU EA WA	398

About this table

HapMap Linkage Disequilibrium images for COL4A1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 120130 disorders: 175780 607595 611773 607595

UniProtKB/Swiss-Prot: CO4A1_HUMAN, P02462

Defects in COL4A1 are a cause of brain small vessel disease with hemorrhage [MIM:607595].

Brain small vessel diseases underlie 20 to 30 percent of ischemic strokes and a larger proportion

of intracerebral hemorrhages. Inheritance is autosomal dominant

Defects in COL4A1 are the cause of hereditary angiopathy with nephropathy, aneurysms, and

muscle cramps (HANAC) [MIM:611773]. The clinical renal manifestations include hematuria and

bilateral large cysts. Histologic analysis revealed complex basement membrane defects in kidney

and skin. The systemic angiopathy appears to affect both small vessels and large arteries

Defects in COL4A1 are a cause of porencephaly type 1 [MIM:175780]; also known as

encephaloclastic porencephaly. Porencephaly is a term used for any cavitation or cerebrospinal

fluid-filled cyst in the brain. Porencephaly type 1 is usually unilateral and results from focal

destructive lesions such as fetal vascular occlusion or birth trauma. Inheritance is autosomal

dominant

5 Novoseek disease relationships for COL4A1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
porencephaly	82.77	4	19238787 (1), 17379824 (1), 19194877 (1)
intracerebral hemorrhage	48.90	4	19238787 (1), 19194877 (1)
neovascularization	36.50	1	10811134 (1)
renal disease	33.49	4	19238787 (1), 18160688 (1), 9047092 (1)
diabetic nephropathies	24.76	2	9047092 (2)

About this table

Human Gene Mutation Database: COL4A1
Genetic Association Database: COL4A1
Human Genome Epidemiology Navigator: COL4A1 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/114 PubMed articles for COL4A1 gene (see all 114 ):

Complete primary structure of the alpha 1-chain of human basement membrane (type IV) collagen. (PubMed id 3691802)^{2, 3, 4} Soininen R.... Tryggvason K. (1987)
COL4A1 mutations and hereditary angiopathy, nephropathy, aneurysms, and muscle cramps. (PubMed id 18160688)^{1, 3, 4} Plaisier E....Ronco P. (2007)
Anti-angiogenic cues from vascular basement membrane collagen. (PubMed id 10811134)^{1, 3, 4} Colorado P.C.... Kalluri R. (2000)
Role of COL4A1 in small-vessel disease and hemorrhagic stroke. (PubMed id 16598045)^{3, 4} Gould D.B....John S.W.M. (2006)
Novel mutations in three families confirm a major role of COL4A1 in hereditary porencephaly. (PubMed id 16107487)^{3, 4} Breedveld G.... Mancini G.M.S. (2006)
Construction of recombinant plasmid and prokaryotic expression in E. coli and biological activity analysis of human placenta arresten gene. (PubMed id 16481288)^{3, 4} Zheng J.P.... Wu T.C. (2006)
Mutations in Col4a1 cause perinatal cerebral hemorrhage and porencephaly. (PubMed id 15905400)^{3, 4} Gould D.B....John S.W.M. (2005)
Single nucleotide polymorphisms associated with aggressive periodontitis and severe chronic periodontitis in Japanese. (PubMed id 15081423)^{3, 6} Suzuki A....Kamoi K. (2004)
The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)^{3, 4} Dunham A.... Ross M.T. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1282	HGNC: 2202	AceView: COL4A1	Ensembl:ENSG00000187498	euGenes: HUgn1282
ECgene: COL4A1	H-InvDB: COL4A1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for COL4A1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for COL4A1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for COL4A1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for COL4A1		Antibodies for COL4A1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for COL4A1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
	Antibodies (COL4A1)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Collagen IV, Collagen I + II + III + IV + V)
	Antibodies (Collagen IV, Collagen I + II + III + IV + V)

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COL4A1 Gene at Home site.
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COL4A1 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for COL4A1

Summaries
for COL4A1

Genomic Location
for COL4A1

Proteins
for COL4A1

Protein Domains/
Families
for COL4A1

Gene Function
for COL4A1

Pathways & Interactions
for COL4A1

Drugs & Compounds
for COL4A1

Transcripts
for COL4A1

Expression
for COL4A1

Orthologs
for COL4A1

Paralogs
for COL4A1

SNPs/Variants
for COL4A1

Disorders & Mutations
for COL4A1

Medical News
for COL4A1

Publications
for COL4A1

Search for COL4A1

Genome Databases showing COL4A1

Other Databases showing COL4A1

Specialized Databases showing COL4A1

Licensable Technologies
for COL4A1

Services
for COL4A1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

COL4A1 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor COL4A1

Summariesfor COL4A1

Genomic Locationfor COL4A1

Proteinsfor COL4A1

Protein Domains/Familiesfor COL4A1

Gene Functionfor COL4A1

Pathways & Interactionsfor COL4A1

Drugs & Compoundsfor COL4A1

Transcriptsfor COL4A1

Expression for COL4A1

Orthologsfor COL4A1

Paralogsfor COL4A1

SNPs/Variantsfor COL4A1

Disorders & Mutationsfor COL4A1

Medical Newsfor COL4A1

Publicationsfor COL4A1

Search for COL4A1

Genome Databases showing COL4A1

Other Databases showing COL4A1

Specialized Databases showing COL4A1

Licensable Technologiesfor COL4A1

Servicesfor COL4A1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for COL4A1

Summaries
for COL4A1

Genomic Location
for COL4A1

Proteins
for COL4A1

Protein Domains/
Families
for COL4A1

Gene Function
for COL4A1

Pathways & Interactions
for COL4A1

Drugs & Compounds
for COL4A1

Transcripts
for COL4A1

Expression
for COL4A1

Orthologs
for COL4A1

Paralogs
for COL4A1

SNPs/Variants
for COL4A1

Disorders & Mutations
for COL4A1

Medical News
for COL4A1

Publications
for COL4A1

Licensable Technologies
for COL4A1

Services
for COL4A1