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COL2A1 Gene

protein-coding   GIFtS: 70
GCID: GC12M048366

Collagen, Type II, Alpha 1

(Previous names: collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal...)
(Previous symbols: SEDC, AOM)
  See COL2A1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Collagen, Type II, Alpha 11 2     COL11A32
AOM1 2     STL12
SEDC1 2     Cartilage Collagen2
Arthroophthalmopathy, Progressive (Stickler Syndrome)1 2     chondrocalcin2
Alpha-1 Type II Collagen2 3     Collagen Alpha-1(II) Chain2
Collagen, Type II, Alpha 1 (Primary Osteoarthritis, Spondyloepiphyseal
Dysplasia, Congenital)1
     Collagen II, Alpha-1 Polypeptide2
ANFH2     

External Ids:    HGNC: 22001   Entrez Gene: 12802   Ensembl: ENSG000001392197   OMIM: 1201405   UniProtKB: P024583   

Export aliases for COL2A1 gene to outside databases

Previous GC identifers: GC12M048379 GC12M048266 GC12M048083 GC12M046653 GC12M045398


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for COL2A1 Gene:
This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous
humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset
familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type
I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a
calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with
chondrodysplasia. There are two transcripts identified for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for COL2A1 Gene:
COL2A1 (collagen, type II, alpha 1) is a protein-coding gene. Diseases associated with COL2A1 include stickler syndrome type 1, and familial avascular necrosis of the femoral head. GO annotations related to this gene include extracellular matrix structural constituent conferring tensile strength and identical protein binding. An important paralog of this gene is COL4A6.

UniProtKB/Swiss-Prot: CO2A1_HUMAN, P02458
Function: Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic
development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the COL2A1 gene promoter:
         HFH-3   SRF   TBP   STAT1   SRF (504 AA)   Lmo2   PPAR-alpha   FOXI1   Pax-3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOL2A1 promoter sequence
   Search Chromatin IP Primers for COL2A1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COL2A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.11   Ensembl cytogenetic band:  12q13.11   HGNC cytogenetic band: 12q12-q13.2

COL2A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COL2A1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M048366:  view genomic region     (about GC identifiers)

Start:
48,366,748 bp from pter      End:
48,398,285 bp from pter
Size:
31,538 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CO2A1_HUMAN, P02458 (See protein sequence)
Recommended Name: Collagen alpha-1(II) chain precursor  
Size: 1487 amino acids; 141785 Da
Subunit: Homotrimers of alpha 1(II) chains
Sequence caution: Sequence=AAH07252.1; Type=Frameshift; Positions=1198;
3 PDB 3D structures from and Proteopedia for COL2A1:
1U5M (3D)        2FSE (3D)        2SEB (3D)    
Secondary accessions: A6NGA0 Q12985 Q14009 Q14044 Q14045 Q14046 Q14047 Q14056 Q14058 Q16672
Q1JQ82 Q2V4X7 Q6LBY1 Q6LBY2 Q6LBY3 Q96IT5 Q99227 Q9UE38 Q9UE39 Q9UE40 Q9UE41 Q9UE42 Q9UE43
Alternative splicing: 3 isoforms:  P02458-2   P02458-1   P02458-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for COL2A1: NX_P02458

Explore proteomics data for COL2A1 at MOPED

Post-translational modifications: 

  • Probably 3-hydroxylated on prolines by LEPREL1 (By similarity). Proline residues at the third position of the
    tripeptide repeating unit (G-X-P) are hydroxylated in some or all of the chains. Proline residues at the second
    position of the tripeptide repeating unit (G-P-X) are hydroxylated in some of the chains1
  • The N-telopeptide is covalently linked to the helical COL2 region of alpha 1(IX), alpha 2(IX) and alpha 3(IX)
    chain. The C-telopeptide is covalently linked to an another site in the helical region of alpha 3(IX) COL21
  • Glycosylation2 at Lys121, Lys218, Lys230, Lys239, Lys305, Lys539, Lys551, Lys1061, Asn1319
  • Modification sites at PhosphoSitePlus

  • See COL2A1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001835.3  NP_149162.2  

    ENSEMBL proteins: 
     ENSP00000369889   ENSP00000338213  
    Reactome Protein details: P02458

    COL2A1 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant COL2A1 Protein
    R&D Systems Recombinant & Natural Proteins for COL2A1 (Collagen II)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for COL2A1
    GenScript Custom Purified and Recombinant Proteins Services for COL2A1
    Novus Biologicals COL2A1 Proteins
    Sino Biological Recombinant Protein for COL2A1
    Sino Biological Cell Lysate for COL2A1
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for COL2A1 

     
    antibodies-online proteins for COL2A1 (6 products) 

     
    antibodies-online peptides for COL2A1

    COL2A1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of COL2A1
    R&D Systems Antibodies for COL2A1 (Collagen II)
    OriGene Antibodies for COL2A1
    OriGene Custom Antibody Services for COL2A1
    Novus Biologicals COL2A1 Antibodies
    Abcam antibodies for COL2A1 (P08123, P02458, P20908)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for COL2A1
    antibodies-online antibodies for COL2A1 (74 products) 

    COL2A1 Assay Products:

    EMD Millipore Kits and Assays for the Analysis of COL2A1
    OriGene Custom Assay Services for COL2A1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for COL2A1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for COL2A1 
    antibodies-online kits for COL2A1 (33 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    COLLAGEN: Collagens

    3 InterPro protein domains:
     IPR000885 Fib_collagen_C
     IPR001007 VWF_C
     IPR008160 Collagen

    Graphical View of Domain Structure for InterPro Entry P02458

    ProtoNet protein and cluster: P02458

    3 Blocks protein domains:
    IPB000885 Fibrillar collagen
    IPB008160 Collagen triple helix repeat
    IPB008161 Collagen helix repeat


    UniProtKB/Swiss-Prot: CO2A1_HUMAN, P02458
    Domain: The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by
    controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen
    fibrils. It binds a calcium ion which is essential for its function (By similarity)
    Similarity: Belongs to the fibrillar collagen family
    Similarity: Contains 1 fibrillar collagen NC1 domain
    Similarity: Contains 1 VWFC domain


    Find genes that share domains with COL2A1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CO2A1_HUMAN, P02458
    Function: Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic
    development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces

         Genatlas biochemistry entry for COL2A1:
    collagen type II,alpha 1,fibril forming,chondrocalcin included,expressed in hyaline cartilage,in the ocular
    vitreous, in the nucleus pulposus of the intervertebral disc and in the inner ear

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005201extracellular matrix structural constituent ----
    GO:0005515protein binding ----
    GO:0030020extracellular matrix structural constituent conferring tensile strength IC8660302
    GO:0042802identical protein binding NAS2587267
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with COL2A1           About GenesLikeMe


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 10 alleles(MGI details for Col2a1) (see all 18):
     adipose tissue  behavior/neurological  cardiovascular system  craniofacial  digestive/alimentary 
     embryogenesis  growth/size/body  hearing/vestibular/ear  immune system  limbs/digits/tail 
     liver/biliary system  mortality/aging  nervous system  normal  renal/urinary system 

    Find genes that share phenotypes with COL2A1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for COL2A1: Col2a1tm1Prc Col2a1tm1.1Ksec

       genOway: Develop your customized and physiologically relevant rodent model for COL2A1

    miRNA
    Products:
        
    miRTarBase miRNAs that target COL2A1:
    hsa-mir-106a-5p (MIRT048314)

    Block miRNA regulation of human, mouse, rat COL2A1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate COL2A1 (see all 17):
    hsa-miR-148b hsa-miR-29c hsa-miR-29a hsa-miR-767-5p hsa-miR-346 hsa-miR-889 hsa-miR-3121-3p hsa-miR-514b-3p
    SwitchGear 3'UTR luciferase reporter plasmidCOL2A1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for COL2A1
    Predesigned siRNA for gene silencing in human, mouse, rat COL2A1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for COL2A1

    Clone
    Products:
         
    OriGene clones in human, mouse for COL2A1 (see all 13)
    OriGene ORF clones in mouse, rat for COL2A1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): COL2A1 (NM_033150)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COL2A1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COL2A1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for COL2A1
    ESI BIO PureStem Progenitor for COL2A1: 
    PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COL2A1

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-10450) for COL2A1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CO2A1_HUMAN, P02458: Secreted, extracellular space, extracellular matrix (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum4
    extracellular4
    cytosol1
    lysosome1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005581collagen ----
    GO:0005585collagen type II IDA8660302
    GO:0005604basement membrane IEA--
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with COL2A1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for COL2A1 About   (see all 17)  
    See pathways by source

    SuperPathContained pathways About
    1Collagen biosynthesis and modifying enzymes
    Collagen biosynthesis and modifying enzymes0.75
    Intrinsic Prothrombin Activation Pathway0.39
    Collagen formation0.75
    Blood Coagulation Cascade0.38
    Assembly of collagen fibrils and other multimeric structures0.62
    2Focal adhesion
    Focal adhesion0.65
    ECM-receptor interaction0.31
    Focal Adhesion0.65
    3Cell adhesion ECM remodeling
    Metalloproteases in connective tissue degradation0.31
    Cell adhesion ECM remodeling0.31
    4Integrin Pathway
    FAK1 Signaling0.67
    UPA-UPAR Pathway0.56
    Integrin Pathway0.67
    Inhibition of Angiogenesis by TSP10.50
    GnRH Signaling0.56
    Transendothelial Migration of Leukocytes0.38
    5ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58


    Find genes that share SuperPaths with COL2A1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for COL2A1
        Articular Cartilage Extracellular Matrix

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for COL2A1 (see all 15)
        MAPK Signaling
    Molecular Mechanisms of Cancer
    PTEN Pathway
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway

    4 GeneGo (Thomson Reuters) Pathways for COL2A1
        Cytoskeleton remodeling Integrin outside-in signaling
    Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Integrin inside-out signaling
    Cell adhesion ECM remodeling

    4 BioSystems Pathways for COL2A1
        Focal Adhesion
    Spinal Cord Injury
    Neural Crest Differentiation
    Endochondral Ossification


    Selected Reactome Pathways for COL2A1 (see all 9)
        Integrin cell surface interactions
    NCAM1 interactions
    Assembly of collagen fibrils and other multimeric structures
    Collagen degradation
    ECM proteoglycans


    5 Kegg Pathways  (Kegg details for COL2A1):
        PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Protein digestion and absorption
    Amoebiasis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including COL2A1: 
              Osteogenesis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              Embryonic Stem Cells in human mouse rat
              Stem Cells in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for COL2A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for COL2A1 (P024582, 3 ENSP000003698894) via UniProtKB, MINT, STRING, and/or I2D (see all 105)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDR1Q083453, ENSP000004060914I2D: score=2 STRING: ENSP00000406091
    ENSG00000137332Q083453I2D: score=2 
    ENSG00000215522Q083453I2D: score=2 
    ENSG00000230456Q083453I2D: score=2 
    ENSG00000234078Q083453I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 32):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development IMP1429602
    GO:0001502cartilage condensation IEA--
    GO:0001503ossification ----
    GO:0001894tissue homeostasis IEA--
    GO:0001958endochondral ossification IEA--

    Find genes that share ontologies with COL2A1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for COL2A1 (CO2A1)

    1 DrugBank Compound for COL2A1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Collagenase-- 9001-12-1target--12890681 17652426 16507130 15299286 14613270

    Selected Novoseek inferred chemical compound relationships for COL2A1 gene (see all 33)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    procollagen 72.1 7 15593085 (2), 1637314 (2), 1860834 (1), 8244341 (1) (see all 5)
    calcium pyrophosphate 56.3 1 11333354 (1)
    alginate 55.3 2 11748585 (1), 11037878 (1)
    hydroxylysine 50 1 10947951 (1)
    glycosaminoglycan 49.8 5 17318897 (1), 15639641 (1), 18985688 (1), 16457813 (1)
    pentosidine 46.7 3 10947951 (2), 11691581 (1)
    n(epsilon)-(carboxymethyl)lysine 44.9 1 10947951 (1)
    pyridinoline 41.3 5 7633791 (1), 1887826 (1), 18369645 (1), 7951150 (1)
    hydroxyproline 34.7 1 1887826 (1)
    serine 22.8 7 11592371 (3), 16507127 (1), 19072565 (1), 9022054 (1) (see all 5)



    Find genes that share compounds with COL2A1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for COL2A1 gene (2 alternative transcripts): 
    NM_001844.4  NM_033150.2  

    Unigene Cluster for COL2A1:

    Collagen, type II, alpha 1
    Hs.408182  [show with all ESTs]
    Unigene Representative Sequence: NM_001844
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380518(uc001rqt.3 uc009zkw.3 uc001rqu.3 uc001rqv.3)
    ENST00000493991 ENST00000337299 ENST00000546974 ENST00000483376 ENST00000474996
    ENST00000466884 ENST00000490609 ENST00000465743
    miRNA
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    Block miRNA regulation of human, mouse, rat COL2A1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate COL2A1 (see all 17):
    hsa-miR-148b hsa-miR-29c hsa-miR-29a hsa-miR-767-5p hsa-miR-346 hsa-miR-889 hsa-miR-3121-3p hsa-miR-514b-3p
    SwitchGear 3'UTR luciferase reporter plasmidCOL2A1 3' UTR sequence
    Inhib. RNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): COL2A1 (NM_033150)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COL2A1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COL2A1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for COL2A1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat COL2A1
      QuantiTect SYBR Green Assays in human, mouse, rat COL2A1
      QuantiFast Probe-based Assays in human, mouse, rat COL2A1
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-10450) for COL2A1 

    Additional mRNA sequence: 

    BC007252.1 BC116449.1 BT007205.1 X06268.1 X13783.1 X16468.1 X16711.1 

    21 DOTS entries:

    DT.95179525  DT.100782871  DT.95263999  DT.100038174  DT.100038169  DT.40132444  DT.102833021  DT.102833022 
    DT.102833024  DT.91785734  DT.92423549  DT.100038168  DT.100038175  DT.102833019  DT.121158231  DT.121630198 
    DT.423497  DT.95263995  DT.95263998  DT.100884016  DT.95171333 

    Selected AceView cDNA sequences (see all 326):

    BU616219 BQ181736 AU122536 CN479651 BQ447571 CA412003 CN479626 CA447998 
    AL834148 N66737 BU552941 CA428335 BQ183392 AA332273 BQ002878 BQ181278 
    CA412021 CA448359 BQ182244 BQ004255 BQ182837 BQ044919 BQ181391 BQ180866 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for COL2A1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                  -         
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:              -                                                                                                                                             

    ExUns: 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^ 46 ^ 47 ^ 48 ^ 49 ^
    SP1:              -                                                                                                                                             
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 50 ^ 51
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for COL2A1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    COL2A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACATAGGAG
    COL2A1 Expression
    About this image


    COL2A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Cartilage (Muscoskeletal System)    fully expand to see all 68 entries
             Chondrocytes Nasal Capsule
             Laryngeal Cartilage
             Juvenile neocartilage (RevaFlex)
             Chondrogenic constructs
             fetal cartilage   
     
     Bone (Muscoskeletal System)    fully expand to see all 49 entries
             Chondrocytes Stylopod Epiphyseal End
             Zeugopod Long Bone
             HyStem+BMP4-induced 4D20.8 cells
             sensory organ/ear/inner ear   
     
     Limb (Muscoskeletal System)    fully expand to see all 12 entries
             Mesenchymal Condensate Cells Zeugopod
             Stylopod Synovial Joint
     
     Primitive Streak (Early Embryonic Tissues)    fully expand to see all 2 entries
             Notochord Cells Notochord
             Notochord
     
     Head Mesenchyme (Muscoskeletal System)    fully expand to see all 2 entries
             Chondrocytes Branchial Arch 2
             Head Mesenchyme
    COL2A1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    COL2A1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.408182

    UniProtKB/Swiss-Prot: CO2A1_HUMAN, P02458
    Tissue specificity: Isoform 2 is highly expressed in juvenile chondrocyte and low in fetal chondrocyte

        Pathway & Disease-focused RT2 Profiler PCR Arrays including COL2A1: 
              Osteogenesis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              Embryonic Stem Cells in human mouse rat
              Stem Cells in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for COL2A1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat COL2A1
    QuantiTect SYBR Green Assays in human, mouse, rat COL2A1
    QuantiFast Probe-based Assays in human, mouse, rat COL2A1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COL2A1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for COL2A1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Col2a11 , 5 collagen, type II, alpha 11, 5 89.08(n)1
    95.09(a)1
      15 (53.97 cM)5
    128241  NM_031163.31  NP_112440.21 
     979756025 
    chicken
    (Gallus gallus)
    Aves COL2A11 collagen, type II, alpha 1 79.82(n)
    92.58(a)
      395069  NM_204426.1  NP_989757.1 
    lizard
    (Anolis carolinensis)
    Reptilia COL2A16
    collagen, type II, alpha 1
    91(a)
    1 ↔ 1
    GL343536.1(339101-431617)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC044962.12   -- 81.53(n)    BC044962.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.271722 Danio rerio cDNA clone IMAGE6788778, partial cds 77.5(n)    BC059180.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cg25C6
    Collagen type IV
    28(a)
    1 → many
    2L(5029609-5037279)


    ENSEMBL Gene Tree for COL2A1 (if available)
    TreeFam Gene Tree for COL2A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for COL2A1 gene
    COL4A62  COL11A22  COL4A52  COL24A12  COL4A42  COL5A32  COL1A12  COL4A22  
    COL5A22  COL5A12  COL4A32  COL1A22  COL7A12  COL3A12  COL27A12  COL4A12  
    COL11A12  
    13 SIMAP similar genes for COL2A1 using alignment to 4 protein entries:     CO2A1_HUMAN (see all proteins):
    COL1A2    COL1A1    COL5A2    COL3A1    type II collagen alpha 1 chain    COL5A1
    FCN2    COL11A1    COL5A3    C1QTNF9    C1QTNF9B    COL24A1
    MARCO

    Find genes that share paralogs with COL2A1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for COL2A1 (see all 1191)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0638944
    Stickler syndrome 1 (STL1)4--see VAR_0638942 G D mis40--------
    VAR_0248234
    Platyspondylic lethal skeletal dysplasia Torrance type (PLSD-T)4--see VAR_0248232 T P mis40--------
    VAR_0176404
    Achondrogenesis 2 (ACG2)4--see VAR_0176402 G V mis40--------
    VAR_0017654
    Spondyloepiphyseal dysplasia congenital type (SEDC)4--see VAR_0017652 G S mis40--------
    VAR_0017494
    Spondyloepiphyseal dysplasia congenital type (SEDC)4--see VAR_0017492 G S mis40--------
    VAR_0171054
    Spondyloepiphyseal dysplasia congenital type (SEDC)4--see VAR_0171052 T M mis40--------
    VAR_0017614
    Achondrogenesis 2 (ACG2)4--see VAR_0017612 G S mis40--------
    VAR_0248264
    Platyspondylic lethal skeletal dysplasia Torrance type (PLSD-T)4--see VAR_0248262 C G mis40--------
    VAR_0017644
    Achondrogenesis 2 (ACG2)4--see VAR_0017642 G R mis40--------
    VAR_0017384
    Stickler syndrome 1 non-syndromic ocular (STL1O)4--see VAR_0017382 G D mis40--------

    HapMap Linkage Disequilibrium report for COL2A1 (48366748 - 48398285 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for COL2A1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832401CNV Loss17160897
    nsv519659CNV Loss19592680
    nsv899061CNV Loss21882294
    nsv525456CNV Gain19592680

    Human Gene Mutation Database (HGMD): COL2A1
    Locus Specific Mutation Databases (LSDB): COL2A1

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing COL2A1
    DNA2.0 Custom Variant and Variant Library Synthesis for COL2A1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 120140   
    OMIM disorders: 108300  156550  200610  183900  184250  132450  271700  604864  151210  215150  608805  150600  609508  609162  
    UniProtKB/Swiss-Prot: CO2A1_HUMAN, P02458
  • Spondyloepiphyseal dysplasia congenital type (SEDC) [MIM:183900]: Disorder characterized by
    disproportionate short stature and pleiotropic involvement of the skeletal and ocular systems. Note=The disease
    is caused by mutations affecting the gene represented in this entry
  • Spondyloepimetaphyseal dysplasia, Strudwick type (SEMDSTWK) [MIM:184250]: A bone disease characterized by
    disproportionate short stature from birth, with a very short trunk and shortened limbs, and skeletal
    abnormalities including lordosis, scoliosis, flattened vertebrae, pectus carinatum, coxa vara, clubfoot, and
    abnormal epiphyses or metaphyses. A distinctive radiographic feature is irregular sclerotic changes, described as
    dappled in the metaphyses of the long bones. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Achondrogenesis 2 (ACG2) [MIM:200610]: A disease characterized by the absence of ossification in the
    vertebral column, sacrum and pubic bones. Note=The disease is caused by mutations affecting the gene represented
    in this entry
  • Legg-Calve-Perthes disease (LCPD) [MIM:150600]: Characterized by loss of circulation to the femoral head,
    resulting in avascular necrosis in a growing child. Clinical pictures of the disease vary, depending on the phase
    of disease progression through ischemia, revascularization, fracture and collapse, and repair and remodeling of
    the bone. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Kniest dysplasia (KD) [MIM:156550]: Moderately severe chondrodysplasia phenotype that results from
    mutations in the COL2A1 gene. Characteristics of the disorder include a short trunk and extremities, mid-face
    hypoplasia, cleft palate, myopia, retinal detachment, and hearing loss. Note=The disease is caused by mutations
    affecting the gene represented in this entry
  • Primary avascular necrosis of femoral head (ANFH) [MIM:608805]: Causes disability that often requires
    surgical intervention. Most cases are sporadic, but families in which there is an autosomal dominant inheritance
    of the disease have been identified. It has been estimated that 300,000 to 600,000 people in the United States
    have ANFH. Approximately 15,000 new cases of this common and disabling disorder are reported annually. The age at
    the onset is earlier than that for osteoarthritis. The diagnosis is typically made when patients are between the
    ages of 30 and 60 years. The clinical manifestations, such as pain on exertion, a limping gait, and a discrepancy
    in leg length, cause considerable disability. Moreover, nearly 10 percent of the 500,000 total-hip arthroplasties
    performed each year in the United States involve patients with ANFH. As a result, this disease creates a
    substantial socioeconomic cost as well as a burden for patients and their families. Note=The disease is caused by
    mutations affecting the gene represented in this entry
  • Osteoarthritis with mild chondrodysplasia (OACD) [MIM:604864]: Osteoarthritis is a common disease that
    produces joint pain and stiffness together with radiologic evidence of progressive degeneration of joint
    cartilage. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Platyspondylic lethal skeletal dysplasia Torrance type (PLSD-T) [MIM:151210]: Platyspondylic lethal
    skeletal dysplasias (PLSDs) are a heterogeneous group of chondrodysplasias characterized by severe platyspondyly
    and limb shortening. PLSD-T is characterized by varying platyspondyly, short ribs with anterior cupping,
    hypoplasia of the lower ilia with broad ischial and pubic bones, and shortening of the tubular bones with splayed
    and cupped metaphyses. Histology of the growth plate typically shows focal hypercellularity with slightly
    enlarged chondrocytes in the resting cartilage and relatively well-preserved columnar formation and ossification
    at the chondro-osseous junction. PLSD-T is generally a perinatally lethal disease, but a few long-term survivors
    have been reported. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Multiple epiphyseal dysplasia with myopia and conductive deafness (EDMMD) [MIM:132450]: A generalized
    skeletal dysplasia associated with significant morbidity. Joint pain, joint deformity, waddling gait, and short
    stature are the main clinical signs and symptoms. EDMMD is an autosomal dominant disorder characterized by
    epiphyseal dysplasia associated with progressive myopia, retinal thinning, crenated cataracts, conductive
    deafness. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Spondyloperipheral dysplasia (SPD) [MIM:271700]: SPD patients manifest short stature, midface hypoplasia,
    sensorineural hearing loss, spondyloepiphyseal dysplasia, platyspondyly and brachydactyly. Note=The disease is
    caused by mutations affecting the gene represented in this entry
  • Stickler syndrome 1 (STL1) [MIM:108300]: An autosomal dominant form of Stickler syndrome, an inherited
    disorder that associates ocular signs with more or less complete forms of Pierre Robin sequence, bone disorders
    and sensorineural deafness. Ocular disorders may include juvenile cataract, myopia, strabismus, vitreoretinal or
    chorioretinal degeneration, retinal detachment, and chronic uveitis. Robin sequence includes an opening in the
    roof of the mouth (a cleft palate), a large tongue (macroglossia), and a small lower jaw (micrognathia). Bones
    are affected by slight platyspondylisis and large, often defective epiphyses. Juvenile joint laxity is followed
    by early signs of arthrosis. The degree of hearing loss varies among affected individuals and may become more
    severe over time. Syndrome expressivity is variable. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Stickler syndrome 1 non-syndromic ocular (STL1O) [MIM:609508]: An autosomal dominant form of Stickler
    syndrome characterized by the ocular signs typically seen in Stickler syndrome type 1 such as cataract, myopia,
    retinal detachment. Systemic features of premature osteoarthritis, cleft palate, hearing impairment, and
    craniofacial abnormalities are either absent or very mild. Note=The disease is caused by mutations affecting the
    gene represented in this entry
  • Rhegmatogenous retinal detachment autosomal dominant (DRRD) [MIM:609508]: A eye disease that most
    frequently results from a break or tear in the retina that allows fluid from the vitreous humor to enter the
    potential space beneath the retina. It is often associated with pathologic myopia and in most cases leads to
    visual impairment or blindness if untreated. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Czech dysplasia (CZECHD) [MIM:609162]: A skeletal dysplasia characterized by early-onset, progressive
    pseudorheumatoid arthritis, platyspondyly, and short third and fourth toes. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • Selected diseases for COL2A1 (see all 55):    
    About MalaCards
    stickler syndrome type 1    familial avascular necrosis of the femoral head    col2a1-related stickler syndrome    spondyloepimetaphyseal dysplasia, strudwick type
    spondyloperipheral dysplasia    spondyloepiphyseal dysplasia congenita    sed, namaqualand type    retinal detachment
    dysspondyloenchondromatosis    avascular necrosis of the femoral head    kniest dysplasia    hypochondrogenesis
    small cell sarcoma    spondylometaphyseal dysplasia corner fracture type    vitreoretinopathy with phalangeal epiphyseal dysplasia    platyspondylic lethal skeletal dysplasia torrance type
    czech dysplasia    achondrogenesis    col2a1-associated stickler syndrome    type ii collagenopathies

    8 diseases from the University of Copenhagen DISEASES database for COL2A1:
    Stickler syndrome     Osteochondrodysplasia     Osteoarthritis     Myopia
    Retinal detachment     Vitreous syneresis     Cleft palate     Brachydactyly

    Find genes that share disorders with COL2A1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for COL2A1 gene (see all 52)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    kniest dysplasia 94.9 19 10406661 (3), 9269170 (2), 9675039 (2), 8863156 (2) (see all 13)
    spondyloepiphyseal dysplasia 94.8 32 8893763 (2), 8325895 (2), 12968670 (2), 8244341 (2) (see all 25)
    achondrogenesis, type ii 89.9 8 10797431 (3), 7829510 (2), 17994563 (2), 15054848 (1)
    stickler syndrome, type i 88.6 4 16152640 (2), 18309337 (1), 16021188 (1)
    sed congenita 82.2 2 12968670 (1), 1978986 (1)
    osteoarthritis 80 51 19019890 (2), 8244341 (2), 11708863 (2), 20131279 (2) (see all 41)
    collagen fibril 78.8 28 1946380 (3), 19287128 (2), 12440941 (2), 12917109 (2) (see all 20)
    spondylometaphyseal dysplasia 77.8 3 7550321 (1), 19764033 (1), 16280719 (1)
    weissenbacher-zweymuller syndrome 77.7 1 9805126 (1)
    osmed 77.2 1 16189708 (1)

    GeneTests: COL2A1
    GeneReviews: COL2A1
    Genetic Association Database (GAD): COL2A1
    Human Genome Epidemiology (HuGE) Navigator: COL2A1 (25 documents)

    Export disorders for COL2A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for COL2A1 gene, integrated from 10 sources (see all 515):
    (articles sorted by number of sources associating them with COL2A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. COL1A1 and COL2A1 genes and myopia susceptibility: evidence of association and suggestive linkage to the COL2A1 locus. (PubMed id 19387081)1, 4, 9 Metlapally R....Young T.L. (amp 2009)
    2. Insulin-like growth factor I gene promoter polymorphism, collagen type II alpha1 (COL2A1) gene, and the prevalence of radiographic osteoarthritis: the Rotterdam Study. (PubMed id 15082485)1, 4, 9 Zhai G....van Duijn C.M. (Ann. Rheum. Dis. 2004)
    3. A novel mutation of COL2A1 resulting in dominantly inherited rhegmatogenous retinal detachment. (PubMed id 15671297)1, 2, 9 Richards A.J.... Snead M.P. (Invest. Ophthalmol. Vis. Sci. 2005)
    4. Autosomal dominant rhegmatogenous retinal detachment associated with an Arg453Ter mutation in the COL2A1 gene. (PubMed id 12939326)1, 4, 9 Go S.L....Hoyng C.B. (amp 2003)
    5. A COL2A1 gene polymorphism is related with advanced stages of osteoarthritis of the knee in Mexican Mestizo population. (PubMed id 19756630)1, 4, 9 GA!lvez-Rosas A....Miranda-Duarte A. (Rheumatol. Int. 2010)
    6. COL2A1 gene polymorphisms and susceptibility to osteoarthritis of the hand in Finnish women. (PubMed id 19019890)1, 4, 9 HAomAolAoinen S....Leino-Arjas P. (Ann. Rheum. Dis. 2009)
    7. Czech dysplasia: report of a large family and further delineation of the phenotype. (PubMed id 18553548)1, 2, 9 Tzschach A....Graul-Neumann L.M. (Am. J. Med. Genet. A 2008)
    8. Widely distributed mutations in the COL2A1 gene produce achondrogenesis type II/hypochondrogenesis. (PubMed id 10797431)1, 2, 9 Koerkkoe J.... Prockop D.J. (Am. J. Med. Genet. 2000)
    9. Variation in the vitreous phenotype of Stickler syndrome can be caused by different amino acid substitutions in the X position of the type II collagen Gly-X-Y triple helix. (PubMed id 11007540)1, 2, 9 Richards A.J.... Snead M.P. (Am. J. Hum. Genet. 2000)
    10. A single base mutation in the type II procollagen gene (COL2A1) that converts glycine alpha 1-247 to serine in a family with late-onset spondyloepiphyseal dysplasia. (PubMed id 8019561)1, 2, 9 Ritvaniemi P.... Prockop D.J. (Hum. Mutat. 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1280 HGNC: 2200 AceView: COL2A1 Ensembl:ENSG00000139219 euGenes: HUgn1280
    ECgene: COL2A1 Kegg: 1280 H-InvDB: COL2A1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for COL2A1 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=COL2A1[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for COL2A1 gene:
    Search GeneIP for patents involving COL2A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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     Search for Antibodies & Assays

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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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     PureStem Progenitor for COL2A1: PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
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     Browse compounds at ApexBio
     Search Addgene for plasmids for COL2A1
      Search eBioscience for proteins for COL2A1
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     genOway: Develop your customized and physiologically relevant rodent model for COL2A1
     antibodies-online antibodies for COL2A1 (74 products)
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     antibodies-online peptides for COL2A1
     antibodies-online proteins for COL2A1 (6 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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