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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

COL2A1 Gene

protein-coding   GIFtS: 69
GCID: GC12M048266

Collagen, Type II, Alpha 1

(Previous names: collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal...)
(Previous symbol: SEDC)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Collagen, Type II, Alpha 11 2     COL11A32
SEDC1 2     Cartilage Collagen2
Alpha-1 Type II Collagen2 3     chondrocalcin2
Collagen, Type II, Alpha 1 (Primary Osteoarthritis, Spondyloepiphyseal
Dysplasia, Congenital)1
     Collagen Alpha-1(II) Chain2
ANFH2     Collagen II, Alpha-1 Polypeptide2
AOM2     

External Ids:    HGNC: 22001   Entrez Gene: 12802   Ensembl: ENSG000001392197   OMIM: 1201405   UniProtKB: P024583   

Export aliases for COL2A1 gene to outside databases

Previous GC identifers: GC12M048379 GC12M048083 GC12M046653 GC12M045398


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for COL2A1 Gene:
This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous
humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset
familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type
I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a
calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with
chondrodysplasia. There are two transcripts identified for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for COL2A1 Gene: 
COL2A1 (collagen, type II, alpha 1) is a protein-coding gene. Diseases associated with COL2A1 include osteoarthritis, and stickler syndrome, and among its related super-pathways are Collagen biosynthesis and modifying enzymes and ECM-receptor interaction. GO annotations related to this gene include extracellular matrix structural constituent conferring tensile strength and identical protein binding. An important paralog of this gene is COL4A6.

UniProtKB/Swiss-Prot: CO2A1_HUMAN, P02458
Function: Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic
development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the COL2A1 gene promoter:
         HFH-3   SRF   TBP   STAT1   SRF (504 AA)   Lmo2   PPAR-alpha   FOXI1   Pax-3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOL2A1 promoter sequence
   Search SABiosciences Chromatin IP Primers for COL2A1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COL2A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.11   Ensembl cytogenetic band:  12q13.11   HGNC cytogenetic band: 12q12-q13.2

COL2A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COL2A1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M048266:  view genomic region     (about GC identifiers)

Start:
48,366,748 bp from pter      End:
48,398,285 bp from pter
Size:
31,538 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CO2A1_HUMAN, P02458 (See protein sequence)
Recommended Name: Collagen alpha-1(II) chain precursor  
Size: 1487 amino acids; 141785 Da
Subunit: Homotrimers of alpha 1(II) chains
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
Sequence caution: Sequence=AAH07252.1; Type=Frameshift; Positions=1198;
3 PDB 3D structures from and Proteopedia for COL2A1:
1U5M (3D)        2FSE (3D)        2SEB (3D)    
Secondary accessions: A6NGA0 Q12985 Q14009 Q14044 Q14045 Q14046 Q14047 Q14056 Q14058 Q16672
Q1JQ82 Q2V4X7 Q6LBY1 Q6LBY2 Q6LBY3 Q96IT5 Q99227 Q9UE38 Q9UE39 Q9UE40 Q9UE41 Q9UE42 Q9UE43
Alternative splicing: 3 isoforms:  P02458-2   P02458-1   P02458-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for COL2A1: NX_P02458

Explore proteomics data for COL2A1 at MOPED 

Post-translational modifications:

  • UniProtKB: Probably 3-hydroxylated on prolines by LEPREL1 (By similarity). Proline residues at the third position of the
    tripeptide repeating unit (G-X-P) are hydroxylated in some or all of the chains. Proline residues at the second
    position of the tripeptide repeating unit (G-P-X) are hydroxylated in some of the chains
  • UniProtKB: The N-telopeptide is covalently linked to the helical COL2 region of alpha 1(IX), alpha 2(IX) and alpha 3(IX)
    chain. The C-telopeptide is covalently linked to an another site in the helical region of alpha 3(IX) COL2
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P02458

  • COL2A1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    COL2A1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001835.3  NP_149162.2  

    ENSEMBL proteins: 
     ENSP00000369889   ENSP00000338213  
    Reactome Protein details: P02458
    Human Recombinant Protein Products for COL2A1: 
    EMD Millipore Purified and/or Recombinant COL2A1 Protein
    R&D Systems Recombinant & Natural Proteins for COL2A1 (Collagen II)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for COL2A1
    GenScript Custom Purified and Recombinant Proteins Services for COL2A1
    Novus Biologicals COL2A1 Proteins
    Sino Biological Recombinant Protein for COL2A1
    Sino Biological Cell Lysate for COL2A1 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005581collagen ----
    GO:0005585collagen type II IDA8660302
    GO:0005604basement membrane IEA--
    GO:0005615extracellular space IEA--

    COL2A1 for ontologies           About GeneDecksing



    COL2A1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of COL2A1
    R&D Systems Antibodies for COL2A1 (Collagen II)
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    GenScript Custom Superior Antibodies Services for COL2A1
    Novus Biologicals COL2A1 Antibodies
    Abcam antibodies for COL2A1
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for COL2A1
    LSBio Antibodies in human, mouse, rat for COL2A1 

    Assay Products for COL2A1: 
    EMD Millipore Kits and Assays for the Analysis of COL2A1
    OriGene Custom Assay Services for COL2A1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for COL2A1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    COLLAGEN: Collagens

    3 InterPro protein domains:
     IPR000885 Fib_collagen_C
     IPR001007 VWF_C
     IPR008160 Collagen

    Graphical View of Domain Structure for InterPro Entry P02458

    ProtoNet protein and cluster: P02458

    3 Blocks protein domains:
    IPB000885 Fibrillar collagen
    IPB008160 Collagen triple helix repeat
    IPB008161 Collagen helix repeat


    UniProtKB/Swiss-Prot: CO2A1_HUMAN, P02458
    Domain: The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by
    controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen
    fibrils. It binds a calcium ion which is essential for its function (By similarity)
    Similarity: Belongs to the fibrillar collagen family
    Similarity: Contains 1 fibrillar collagen NC1 domain
    Similarity: Contains 1 VWFC domain


    COL2A1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CO2A1_HUMAN, P02458
    Function: Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic
    development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces

         Genatlas biochemistry entry for COL2A1:
    collagen type II,alpha 1,fibril forming,chondrocalcin included,expressed in hyaline cartilage,in the ocular
    vitreous, in the nucleus pulposus of the intervertebral disc and in the inner ear

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005201extracellular matrix structural constituent ----
    GO:0005515protein binding ----
    GO:0030020extracellular matrix structural constituent conferring tensile strength IC8660302
    GO:0042802identical protein binding NAS2587267
    GO:0046872metal ion binding IEA--
         
    COL2A1 for ontologies           About GeneDecksing


    Phenotypes:
         15/18 MGI mutant phenotypes (inferred from 9 alleles(MGI details for Col2a1) (see all 18):
     adipose tissue  behavior/neurological  cardiovascular system  craniofacial  digestive/alimentary 
     embryogenesis  growth/size  hearing/vestibular/ear  immune system  limbs/digits/tail 
     liver/biliary system  mortality/aging  nervous system  normal  renal/urinary system 

    COL2A1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for COL2A1: Col2a1tm1Prc Col2a1tm1.1Ksec

       inGenious Targeting Laboratory - Custom generated mouse model solutions for COL2A1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for COL2A1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for COL2A1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for COL2A1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COL2A1
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate COL2A1 (see all 17):
    hsa-miR-148b hsa-miR-29c hsa-miR-29a hsa-miR-767-5p hsa-miR-346 hsa-miR-889 hsa-miR-3121-3p hsa-miR-514b-3p
    SwitchGear 3'UTR luciferase reporter plasmidCOL2A1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for COL2A1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COL2A1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for COL2A1
    Sirion Biotech Customized adenovirus for overexpression of COL2A1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    OriGene ORF clones in mouse, rat for COL2A1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): COL2A1 (NM_033150)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COL2A1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COL2A1
    Sirion Biotech Customized lentivirus for stable overexpression of COL2A1 
                         Customized lentivirus expression plasmids for stable overexpression of COL2A1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for COL2A1
    LifeMap BioReagents: cell lines associated with COL2A1: Chondrogenic Package 4D20.8,
    Chondrogenic Package 7PEND24, Chondrogenic Package 7SMOO32,
    Chondrogenic Package E15, Chondrogenic Package MEL2,
    Chondrogenic Package SM30, PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COL2A1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for COL2A1 About   (see all 22)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Collagen biosynthesis and modifying enzymes
    Collagen biosynthesis and modifying enzymes0.74
    Intrinsic Prothrombin Activation Pathway0.40
    Collagen formation0.74
    Extracellular matrix organization0.39
    Assembly of collagen fibrils and other multimeric structures0.65
    Blood Coagulation Cascade0.39
    2Non-integrin membrane-ECM interactions
    Non-integrin membrane-ECM interactions0.44
    ECM proteoglycans0.38
    ECM-receptor interaction0.42
    Integrin cell surface interactions0.32
    3Focal Adhesion
    Focal Adhesion0.64
    Focal adhesion0.64
    4Cell adhesion ECM remodeling
    Cell adhesion ECM remodeling0.31
    Metalloproteases in connective tissue degradation0.31
    5Integrin Pathway
    Integrin Pathway0.67
    UPA-UPAR Pathway0.56
    FAK1 Signaling0.67
    Inhibition of Angiogenesis by TSP10.50
    GnRH Signaling0.56
    Transendothelial Migration of Leukocytes0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/6 EMD Millipore Pathways for COL2A1 (see all 6)
        Cell adhesion Integrin-mediated cell adhesion and migration
    Development Hedgehog and PTH signaling pathways in bone and cartilage development
    Cytoskeleton remodeling Integrin outside-in signaling
    Cell adhesion Integrin inside-out signaling
    Cell adhesion ECM remodeling

    1 R&D Systems Pathway for COL2A1
        Articular Cartilage Extracellular Matrix

    5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for COL2A1 (see all 15)
        MAPK Signaling
    Molecular Mechanisms of Cancer
    PTEN Pathway
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway

    4 GeneGo (Thomson Reuters) Pathways for COL2A1
        Cytoskeleton remodeling Integrin outside-in signaling
    Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Integrin inside-out signaling
    Cell adhesion ECM remodeling

    4 BioSystems Pathways for COL2A1
        Focal Adhesion
    Spinal Cord Injury
    Neural Crest Differentiation
    Endochondral Ossification


    5/15        Reactome Pathways for COL2A1 (see all 15)
        Developmental Biology
    Integrin cell surface interactions
    NCAM1 interactions
    Assembly of collagen fibrils and other multimeric structures
    NCAM signaling for neurite out-growth


    5         Kegg Pathways  (Kegg details for COL2A1):
        PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Protein digestion and absorption
    Amoebiasis


    COL2A1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for COL2A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/104 Interacting proteins for COL2A1 (P024582, 3 ENSP000003698894) via UniProtKB, MINT, STRING, and/or I2D (see all 104)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDR1Q083453, ENSP000004060914I2D: score=2 STRING: ENSP00000406091
    ENSG00000137332Q083453I2D: score=2 
    ENSG00000215522Q083453I2D: score=2 
    ENSG00000230456Q083453I2D: score=2 
    ENSG00000234078Q083453I2D: score=2 
    About this table

    Gene Ontology (GO): 5/31 biological process terms (GO ID links to tree view) (see all 31):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development IMP1429602
    GO:0001502cartilage condensation IEA--
    GO:0001503ossification ----
    GO:0001894tissue homeostasis IEA--
    GO:0001958endochondral ossification IEA--

    COL2A1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    COL2A1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for COL2A1 (CO2A1)

    1 DrugBank Compound for COL2A1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Collagenase-- 9001-12-1target--12890681 17652426 16507130 15299286 14613270

    10/33 Novoseek inferred chemical compound relationships for COL2A1 gene (see all 33)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    procollagen 72.1 7 15593085 (2), 1637314 (2), 1860834 (1), 8244341 (1) (see all 5)
    calcium pyrophosphate 56.3 1 11333354 (1)
    alginate 55.3 2 11748585 (1), 11037878 (1)
    hydroxylysine 50 1 10947951 (1)
    glycosaminoglycan 49.8 5 17318897 (1), 15639641 (1), 18985688 (1), 16457813 (1)
    pentosidine 46.7 3 10947951 (2), 11691581 (1)
    n(epsilon)-(carboxymethyl)lysine 44.9 1 10947951 (1)
    pyridinoline 41.3 5 7633791 (1), 1887826 (1), 18369645 (1), 7951150 (1)
    hydroxyproline 34.7 1 1887826 (1)
    serine 22.8 7 11592371 (3), 16507127 (1), 19072565 (1), 9022054 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about COL2A1 / CO2A1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for COL2A1 gene (2 alternative transcripts): 
    NM_001844.4  NM_033150.2  

    Unigene Cluster for COL2A1:

    Collagen, type II, alpha 1
    Hs.408182  [show with all ESTs]
    Unigene Representative Sequence: NM_001844
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380518(uc001rqt.3 uc009zkw.3 uc001rqu.3 uc001rqv.3)
    ENST00000493991 ENST00000337299 ENST00000546974 ENST00000483376 ENST00000474996
    ENST00000466884 ENST00000490609 ENST00000465743
    miRNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COL2A1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COL2A1
    Sirion Biotech Customized lentivirus for stable overexpression of COL2A1 
                         Customized lentivirus expression plasmids for stable overexpression of COL2A1 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COL2A1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COL2A1

    Additional mRNA sequence: 

    BC007252.1 BC116449.1 BT007205.1 X06268.1 X13783.1 X16468.1 X16711.1 

    21 DOTS entries:

    DT.95179525  DT.100782871  DT.95263999  DT.100038174  DT.100038169  DT.40132444  DT.102833021  DT.102833022 
    DT.102833024  DT.91785734  DT.92423549  DT.100038168  DT.100038175  DT.102833019  DT.121158231  DT.121630198 
    DT.423497  DT.95263995  DT.95263998  DT.100884016  DT.95171333 

    24/326 AceView cDNA sequences (see all 326):

    BM711337 BU626288 BQ182505 BQ181566 CA447976 BX095530 AA332273 BQ182175 
    BQ007625 T28361 CA412021 CA412003 CN479625 BQ182729 BQ182581 BQ007886 
    CA411736 BQ182784 BQ183126 BU616616 N66737 BQ182210 BQ182837 BQ181019 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for COL2A1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                  -         
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:              -                                                                                                                                             

    ExUns: 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^ 46 ^ 47 ^ 48 ^ 49 ^
    SP1:              -                                                                                                                                             
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 50 ^ 51
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for COL2A1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    COL2A1 expression in normal human tissues (normalized intensities)      COL2A1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACATAGGAG
    COL2A1 Expression
    About this image


    COL2A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/21 selected tissues (see all 21) fully expand
     
     Cartilage (Muscoskeletal System)    fully expand to see all 75 entries
             Chondrocytes Nasal Capsule
             Juvenile neocartilage (RevaFlex)
             Embryoid body constructs ( Generation of fibrocartilage-like constructs )
             sensory organ/nose/nasal septum   
     
     Bone (Muscoskeletal System)    fully expand to see all 48 entries
             Chondrocytes Sacral Vertebrae
             Zeugopod Long Bone
             HyStem+BMP4-induced 4D20.8 cells
             sensory organ/ear/inner ear   
     
     Limb (Muscoskeletal System)    fully expand to see all 12 entries
             Mesenchymal Condensate Cells Zeugopod
             Stylopod Synovial Joint
     
     Lung (Respiratory System)    fully expand to see all 4 entries
             Chondrocytes Tracheal Cartilage
             Trachea   
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Foregut
             Primitive gut tube-like cells ( A scalable, suspension protocol for derivation of...

    See COL2A1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for COL2A1

    SOURCE GeneReport for Unigene cluster: Hs.408182

    UniProtKB/Swiss-Prot: CO2A1_HUMAN, P02458
    Tissue specificity: Isoform 2 is highly expressed in juvenile chondrocyte and low in fetal chondrocyte

        SABiosciences Expression via Pathway-Focused PCR Arrays including COL2A1: 
              Osteogenesis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              Embryonic Stem Cells in human mouse rat
              Stem Cells in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for COL2A1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat COL2A1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COL2A1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COL2A1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COL2A1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for COL2A1 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Col2a11 , 5 collagen, type II, alpha 11, 5 89.23(n)1
    95.29(a)1
      15 (53.97 cM)5
    128241  NM_031163.31  NP_112440.21 
     979756025 
    chicken
    (Gallus gallus)
    Aves COL2A11 collagen, type II, alpha 1 79.82(n)
    92.58(a)
      395069  NM_204426.1  NP_989757.1 
    lizard
    (Anolis carolinensis)
    Reptilia COL2A16
    Uncharacterized protein
    91(a)
    1 ↔ 1
    GL343536.1(339101-431617)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC044962.12   -- 81.53(n)    BC044962.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.271722 Danio rerio cDNA clone IMAGE6788778, partial cds 77.5(n)    BC059180.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0116201 AGAP011620-PA 55.69(n)
    57.05(a)
      1281010  XM_320884.4  XP_320884.4 


    ENSEMBL Gene Tree for COL2A1 (if available)
    TreeFam Gene Tree for COL2A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for COL2A1 gene
    COL4A62  COL11A22  COL4A52  COL24A12  COL4A42  COL5A32  COL1A12  COL4A22  
    COL5A22  COL5A12  COL4A32  COL1A22  COL7A12  COL3A12  COL27A12  COL4A12  
    COL11A12  
    13 SIMAP similar genes for COL2A1 using alignment to 4 protein entries:     CO2A1_HUMAN (see all proteins):
    COL1A2    COL1A1    COL5A2    COL3A1    type II collagen alpha 1 chain    COL5A1
    FCN2    COL11A1    COL5A3    C1QTNF9    C1QTNF9B    COL24A1
    MARCO

    COL2A1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1191 SNPs in COL2A1 are shown (see all 1191)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0638944
    Stickler syndrome 1 (STL1)4--see VAR_0638942 G D mis40--------
    VAR_0248234
    Platyspondylic lethal skeletal dysplasia Torrance type (PLSD-T)4--see VAR_0248232 T P mis40--------
    VAR_0176404
    Achondrogenesis 2 (ACG2)4--see VAR_0176402 G V mis40--------
    VAR_0017654
    Spondyloepiphyseal dysplasia congenital type (SEDC)4--see VAR_0017652 G S mis40--------
    VAR_0017494
    Spondyloepiphyseal dysplasia congenital type (SEDC)4--see VAR_0017492 G S mis40--------
    VAR_0171054
    Spondyloepiphyseal dysplasia congenital type (SEDC)4--see VAR_0171052 T M mis40--------
    VAR_0017614
    Achondrogenesis 2 (ACG2)4--see VAR_0017612 G S mis40--------
    VAR_0248264
    Platyspondylic lethal skeletal dysplasia Torrance type (PLSD-T)4--see VAR_0248262 C G mis40--------
    VAR_0017644
    Achondrogenesis 2 (ACG2)4--see VAR_0017642 G R mis40--------
    VAR_0017384
    Stickler syndrome 1 non-syndromic ocular (STL1O)4--see VAR_0017382 G D mis40--------

    HapMap Linkage Disequilibrium report for COL2A1 (48366748 - 48398285 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for COL2A1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832401CNV Loss17160897
    nsv519659CNV Loss19592680
    nsv899061CNV Loss21882294
    nsv525456CNV Gain19592680


    Human Gene Mutation Database (HGMD): COL2A1

    Locus Specific Mutation Databases (LSDB): COL2A1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing COL2A1
    DNA2.0 Custom Variant and Variant Library Synthesis for COL2A1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 120140   
    OMIM disorders: 108300  156550  200610  183900  184250  132450  271700  604864  151210  215150  608805  150600  609508  
    UniProtKB/Swiss-Prot: CO2A1_HUMAN, P02458
  • Spondyloepiphyseal dysplasia congenital type (SEDC) [MIM:183900]: Disorder characterized by
    disproportionate short stature and pleiotropic involvement of the skeletal and ocular systems. Note=The disease
    is caused by mutations affecting the gene represented in this entry
  • Spondyloepimetaphyseal dysplasia, Strudwick type (SEMDSTWK) [MIM:184250]: A bone disease characterized by
    disproportionate short stature from birth, with a very short trunk and shortened limbs, and skeletal
    abnormalities including lordosis, scoliosis, flattened vertebrae, pectus carinatum, coxa vara, clubfoot, and
    abnormal epiphyses or metaphyses. A distinctive radiographic feature is irregular sclerotic changes, described as
    dappled in the metaphyses of the long bones. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Achondrogenesis 2 (ACG2) [MIM:200610]: A disease characterized by the absence of ossification in the
    vertebral column, sacrum and pubic bones. Note=The disease is caused by mutations affecting the gene represented
    in this entry
  • Legg-Calve-Perthes disease (LCPD) [MIM:150600]: Characterized by loss of circulation to the femoral head,
    resulting in avascular necrosis in a growing child. Clinical pictures of the disease vary, depending on the phase
    of disease progression through ischemia, revascularization, fracture and collapse, and repair and remodeling of
    the bone. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Kniest dysplasia (KD) [MIM:156550]: Moderately severe chondrodysplasia phenotype that results from
    mutations in the COL2A1 gene. Characteristics of the disorder include a short trunk and extremities, mid-face
    hypoplasia, cleft palate, myopia, retinal detachment, and hearing loss. Note=The disease is caused by mutations
    affecting the gene represented in this entry
  • Primary avascular necrosis of femoral head (ANFH) [MIM:608805]: Causes disability that often requires
    surgical intervention. Most cases are sporadic, but families in which there is an autosomal dominant inheritance
    of the disease have been identified. It has been estimated that 300,000 to 600,000 people in the United States
    have ANFH. Approximately 15,000 new cases of this common and disabling disorder are reported annually. The age at
    the onset is earlier than that for osteoarthritis. The diagnosis is typically made when patients are between the
    ages of 30 and 60 years. The clinical manifestations, such as pain on exertion, a limping gait, and a discrepancy
    in leg length, cause considerable disability. Moreover, nearly 10 percent of the 500,000 total-hip arthroplasties
    performed each year in the United States involve patients with ANFH. As a result, this disease creates a
    substantial socioeconomic cost as well as a burden for patients and their families. Note=The disease is caused by
    mutations affecting the gene represented in this entry
  • Osteoarthritis with mild chondrodysplasia (OACD) [MIM:604864]: Osteoarthritis is a common disease that
    produces joint pain and stiffness together with radiologic evidence of progressive degeneration of joint
    cartilage. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Platyspondylic lethal skeletal dysplasia Torrance type (PLSD-T) [MIM:151210]: Platyspondylic lethal
    skeletal dysplasias (PLSDs) are a heterogeneous group of chondrodysplasias characterized by severe platyspondyly
    and limb shortening. PLSD-T is characterized by varying platyspondyly, short ribs with anterior cupping,
    hypoplasia of the lower ilia with broad ischial and pubic bones, and shortening of the tubular bones with splayed
    and cupped metaphyses. Histology of the growth plate typically shows focal hypercellularity with slightly
    enlarged chondrocytes in the resting cartilage and relatively well-preserved columnar formation and ossification
    at the chondro-osseous junction. PLSD-T is generally a perinatally lethal disease, but a few long-term survivors
    have been reported. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Multiple epiphyseal dysplasia with myopia and conductive deafness (EDMMD) [MIM:132450]: A generalized
    skeletal dysplasia associated with significant morbidity. Joint pain, joint deformity, waddling gait, and short
    stature are the main clinical signs and symptoms. EDMMD is an autosomal dominant disorder characterized by
    epiphyseal dysplasia associated with progressive myopia, retinal thinning, crenated cataracts, conductive
    deafness. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Spondyloperipheral dysplasia (SPD) [MIM:271700]: SPD patients manifest short stature, midface hypoplasia,
    sensorineural hearing loss, spondyloepiphyseal dysplasia, platyspondyly and brachydactyly. Note=The disease is
    caused by mutations affecting the gene represented in this entry
  • Stickler syndrome 1 (STL1) [MIM:108300]: An autosomal dominant form of Stickler syndrome, an inherited
    disorder that associates ocular signs with more or less complete forms of Pierre Robin sequence, bone disorders
    and sensorineural deafness. Ocular disorders may include juvenile cataract, myopia, strabismus, vitreoretinal or
    chorioretinal degeneration, retinal detachment, and chronic uveitis. Robin sequence includes an opening in the
    roof of the mouth (a cleft palate), a large tongue (macroglossia), and a small lower jaw (micrognathia). Bones
    are affected by slight platyspondylisis and large, often defective epiphyses. Juvenile joint laxity is followed
    by early signs of arthrosis. The degree of hearing loss varies among affected individuals and may become more
    severe over time. Syndrome expressivity is variable. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Stickler syndrome 1 non-syndromic ocular (STL1O) [MIM:609508]: An autosomal dominant form of Stickler
    syndrome characterized by the ocular signs typically seen in Stickler syndrome type 1 such as cataract, myopia,
    retinal detachment. Systemic features of premature osteoarthritis, cleft palate, hearing impairment, and
    craniofacial abnormalities are either absent or very mild. Note=The disease is caused by mutations affecting the
    gene represented in this entry
  • Rhegmatogenous retinal detachment autosomal dominant (DRRD) [MIM:609508]: A eye disease that most
    frequently results from a break or tear in the retina that allows fluid from the vitreous humor to enter the
    potential space beneath the retina. It is often associated with pathologic myopia and in most cases leads to
    visual impairment or blindness if untreated. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Czech dysplasia (CZECHD) [MIM:609162]: A skeletal dysplasia characterized by early-onset, progressive
    pseudorheumatoid arthritis, platyspondyly, and short third and fourth toes. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 20/95 diseases for COL2A1 (see all 95):    About MalaCards
    osteoarthritis    stickler syndrome    kniest dysplasia    spondyloepiphyseal dysplasia congenita
    hypochondrogenesis    achondrogenesis type ii    achondrogenesis    retinal detachment
    czech dysplasia    spondyloperipheral dysplasia    avascular necrosis of the femoral head    type ii collagenopathies
    spondyloepimetaphyseal dysplasia, strudwick type    legg-calve-perthes disease    czech dysplasia metatarsal type    platyspondylic skeletal dysplasia, torrance type
    small cell sarcoma    platyspondylic lethal skeletal dysplasia torrance type    col2a1-associated stickler syndrome    stickler syndrome type 1

    8 diseases from the University of Copenhagen DISEASES database for COL2A1:
    Stickler syndrome     Osteochondrodysplasia     Osteoarthritis     Myopia
    Retinal detachment     Vitreous syneresis     Cleft palate     Brachydactyly

    COL2A1 for disorders           About GeneDecksing

    10/52 Novoseek inferred disease relationships for COL2A1 gene (see all 52)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    kniest dysplasia 94.9 19 10406661 (3), 9269170 (2), 9675039 (2), 8863156 (2) (see all 13)
    spondyloepiphyseal dysplasia 94.8 32 8893763 (2), 8325895 (2), 12968670 (2), 8244341 (2) (see all 25)
    achondrogenesis, type ii 89.9 8 10797431 (3), 7829510 (2), 17994563 (2), 15054848 (1)
    stickler syndrome, type i 88.6 4 16152640 (2), 18309337 (1), 16021188 (1)
    sed congenita 82.2 2 12968670 (1), 1978986 (1)
    osteoarthritis 80 51 19019890 (2), 8244341 (2), 11708863 (2), 20131279 (2) (see all 41)
    collagen fibril 78.8 28 1946380 (3), 19287128 (2), 12440941 (2), 12917109 (2) (see all 20)
    spondylometaphyseal dysplasia 77.8 3 7550321 (1), 19764033 (1), 16280719 (1)
    weissenbacher-zweymuller syndrome 77.7 1 9805126 (1)
    osmed 77.2 1 16189708 (1)

    GeneTests: COL2A1
    GeneReviews: COL2A1
    Genetic Association Database (GAD): COL2A1
    Human Genome Epidemiology (HuGE) Navigator: COL2A1 (25 documents)

    Export disorders for COL2A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for COL2A1 gene, integrated from 9 sources (see all 509):
    (articles sorted by number of sources associating them with COL2A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. COL1A1, COL2A1 Genes and Myopia Susceptibility: Evidence of Association and Suggestive Linkage to the COL2A1 Locus. (PubMed id 19387081)1, 4, 9 Metlapally R....Young T.L. (2009)
    2. Insulin-like growth factor I gene promoter polymorphism, collagen type II alpha1 (COL2A1) gene, and the prevalence of radiographic osteoarthritis: the Rotterdam Study. (PubMed id 15082485)1, 4, 9 Zhai G....van Duijn C.M. (2004)
    3. A novel mutation of COL2A1 resulting in dominantly inherited rhegmatogenous retinal detachment. (PubMed id 15671297)1, 2, 9 Richards A.J.... Snead M.P. (2005)
    4. Autosomal dominant rhegmatogenous retinal detachment associated with an Arg453Ter mutation in the COL2A1 gene. (PubMed id 12939326)1, 4, 9 Go S.L....Hoyng C.B. (2003)
    5. A COL2A1 gene polymorphism is related with advanced s tages of osteoarthritis of the knee in Mexican Mestizo population. (PubMed id 19756630)1, 4, 9 GA!lvez-Rosas A....Miranda-Duarte A. (2010)
    6. Czech dysplasia: report of a large family and further delineation of the phenotype. (PubMed id 18553548)1, 2, 9 Tzschach A....Graul-Neumann L.M. (2008)
    7. COL2A1 gene polymorphisms and susceptibility to hand osteoarthritis in Finnish women. (PubMed id 19019890)1, 4, 9 Hamalainen S.H....Leino-Arjas P. (2008)
    8. Widely distributed mutations in the COL2A1 gene produce achondrogenesis type II/hypochondrogenesis. (PubMed id 10797431)1, 2, 9 Koerkkoe J.... Prockop D.J. (2000)
    9. Variation in the vitreous phenotype of Stickler syndrome can be caused by different amino acid substitutions in the X position of the type II collagen Gly-X-Y triple helix. (PubMed id 11007540)1, 2, 9 Richards A.J.... Snead M.P. (2000)
    10. A single base mutation in the type II procollagen gene (COL2A1) that converts glycine alpha 1-247 to serine in a family with late-onset spondyloepiphyseal dysplasia. (PubMed id 8019561)1, 2, 9 Ritvaniemi P.... Prockop D.J. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1280 HGNC: 2200 AceView: COL2A1 Ensembl:ENSG00000139219 euGenes: HUgn1280
    ECgene: COL2A1 Kegg: 1280 H-InvDB: COL2A1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for COL2A1 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/COL2A1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for COL2A1 gene:
    Search GeneIP for patents involving COL2A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Purified and/or Recombinant COL2A1 Protein
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     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat COL2A1
     QIAGEN SeqTarget long-range PCR primers for resequencing COL2A1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COL2A1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COL2A1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COL2A1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COL2A1
     GenScript Custom Purified and Recombinant Proteins Services for COL2A1 GenScript cDNA clones with any tag delivered in your preferred vector for COL2A1
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     Search for Antibodies & Assays

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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
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     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Cell Lines associated with COL2A1: Chondrogenic Package 4D20.8,
    Chondrogenic Package 7PEND24, Chondrogenic Package 7SMOO32,
    Chondrogenic Package E15, Chondrogenic Package MEL2,
    Chondrogenic Package SM30, PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
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     ThermoFisher Antibody for COL2A1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COL2A1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for COL2A1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for COL2A1
    Customized:
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     adenovirus for overexpression of COL2A1
     LSBio Antibodies in human, mouse, rat for COL2A1
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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