Aliases for COL28A1 Gene
Aliases for COL28A1 Gene
External Ids for COL28A1 Gene
- HGNC: 22442
- Entrez Gene: 340267
- Ensembl: ENSG00000215018
- OMIM: 609996
- UniProtKB: Q2UY09
Previous GeneCards Identifiers for COL28A1 Gene
- GC07M007364
- GC07M007246
Summaries for COL28A1 Gene
-
COL28A1 belongs to a class of collagens containing von Willebrand factor (VWF; MIM 613160) type A (VWFA) domains (Veit et al., 2006 [PubMed 16330543]).[supplied by OMIM, Nov 2010]
GeneCards Summary for COL28A1 Gene
COL28A1 (Collagen Type XXVIII Alpha 1 Chain) is a Protein Coding gene. Among its related pathways are Collagen chain trimerization and Degradation of the extracellular matrix. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is COL6A2.
UniProtKB/Swiss-Prot for COL28A1 Gene
-
May act as a cell-binding protein.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COL28A1 Gene
Genomics for COL28A1 Gene
Regulatory Elements for COL28A1 Gene
- Transcription factor binding sites by QIAGEN in the COL28A1 gene promoter:
Regulatory Element Products
Genomic Location for COL28A1 Gene
- Chromosome:
- 7
- Start:
- 7,338,549 bp from pter
- End:
- 7,537,277 bp from pter
- Size:
- 198,729 bases
- Orientation:
- Minus strand
Genomic View for COL28A1 Gene
- Cytogenetic band:
-
- 7p21.3 by Ensembl
- 7p21.3 by Entrez Gene
- 7p21.3 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for COL28A1 Gene
Proteins for COL28A1 Gene
-
Protein details for COL28A1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q2UY09-COSA1_HUMAN
- Recommended name:
- Collagen alpha-1(XXVIII) chain
- Protein Accession:
- Q2UY09
- A4D101
- A4D106
- A4D107
- A8MVR2
- B9EGX9
- Q2UY07
- Q2UY08
Protein attributes for COL28A1 Gene
- Size:
- 1125 amino acids
- Molecular mass:
- 116657 Da
- Quaternary structure:
-
- Trimer or homomer. Secreted as a 135 kDa monomer under reducing conditions and as a homotrimer under non-reducing conditions (By similarity).
- SequenceCaution:
-
- Sequence=EAL24305.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAL24306.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAL24307.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for COL28A1 Gene
Post-translational modifications for COL28A1 Gene
Other Protein References for COL28A1 Gene
Antibody Products
- Novus Biologicals Antibodies for COL28A1
- Invitrogen Antibodies for COL28A1
- Search GeneTex for Antibodies for COL28A1
Protein Products
-
OriGene Purified Proteins for COL28A1
- Search Origene for MassSpec and Protein Over-expression Lysates for COL28A1
- Origene Custom Protein Services for COL28A1
- Novus Biologicals proteins for COL28A1
- Search GeneTex for Proteins for COL28A1
Assay Products
- antibodies-online Kits for COL28A1: See all 8
No data available for DME Specific Peptides for COL28A1 Gene
Domains & Families for COL28A1 Gene
Gene Families for COL28A1 Gene
- HGNC:
Protein Domains for COL28A1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for COL28A1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q2UY09- Family:
-
- Belongs to the VWA-containing collagen family.
Function for COL28A1 Gene
Molecular function for COL28A1 Gene
- UniProtKB/Swiss-Prot Function:
- May act as a cell-binding protein.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004867 | serine-type endopeptidase inhibitor activity | IEA | -- |
| GO:0030414 | peptidase inhibitor activity | IEA | -- |
Phenotypes for COL28A1 Gene
- GenomeRNAi human phenotypes for COL28A1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for COL28A1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for COL28A1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for COL28A1 gene
- Search ViGene Biosciences for COL28A1
CRISPR Products
-
OriGene CRISPR knockouts for COL28A1
-
Santa Cruz Biotechnology (SCBT) CRISPR for COL28A1
- GenScript: Design CRISPR guide RNA sequences for COL28A1
miRNA Products
- Search ViGene Biosciences for COL28A1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for COL28A1
- Browse OriGene Inhibitory RNA Products For COL28A1
-
ViGene Biosciences ready-to-package AAV shRNAs for COL28A1 gene
Clone Products
-
OriGene ORF clones in human for COL28A1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for COL28A1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for COL28A1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for COL28A1
-
ViGene Biosciences adenoviral particle packaged cDNA for COL28A1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for COL28A1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for COL28A1 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for COL28A1 Gene
Localization for COL28A1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for COL28A1 Gene
- Secreted, extracellular space, extracellular matrix, basement membrane.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005578 | proteinaceous extracellular matrix | IEA | -- |
| GO:0005581 | collagen trimer | IEA | -- |
| GO:0005604 | basement membrane | IEA | -- |
| GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
Pathways & Interactions for COL28A1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Collagen chain trimerization | ||
| 2 | Degradation of the extracellular matrix | ||
Pathways by source for COL28A1 Gene
4 Reactome pathways for COL28A1 Gene
Interacting Proteins for COL28A1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007155 | cell adhesion | IEA | -- |
| GO:0010466 | negative regulation of peptidase activity | IEA | -- |
| GO:0010951 | negative regulation of endopeptidase activity | IEA | -- |
No data available for SIGNOR curated interactions for COL28A1 Gene
Transcripts for COL28A1 Gene
mRNA/cDNA for COL28A1 Gene
- (12) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (2) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for COL28A1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for COL28A1
-
Santa Cruz Biotechnology (SCBT) CRISPR for COL28A1
- GenScript: Design CRISPR guide RNA sequences for COL28A1
miRNA Products
- Search ViGene Biosciences for COL28A1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for COL28A1
- Browse OriGene Inhibitory RNA Products For COL28A1
-
ViGene Biosciences ready-to-package AAV shRNAs for COL28A1 gene
Clone Products
-
OriGene ORF clones in human for COL28A1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for COL28A1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for COL28A1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for COL28A1 Gene
mRNA differential expression in normal tissues according to GTEx for COL28A1 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for COL28A1 Gene
NURSA nuclear receptor signaling pathways regulating expression of COL28A1 Gene:
COL28A1SOURCE GeneReport for Unigene cluster for COL28A1 Gene:
Hs.491104Evidence on tissue expression from TISSUES for COL28A1 Gene
- Lung(4.1)
Primer Products
-
OriGene qPCR primer pairs for COL28A1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for COL28A1 Gene
Orthologs for COL28A1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | COL28A1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | COL28A1 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Col28a1 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Col28a1 34 16 35 |
|
||
| cow (Bos Taurus) |
Mammalia | COL28A1 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | COL28A1 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
ManyToMany | |
| chicken (Gallus gallus) |
Aves | COL28A1 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | COL28A1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | col28a1 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | col28a1 34 35 |
|
||
| COL28A1 (2 of 3) 35 |
|
OneToMany | |||
| col6a3 35 |
|
OneToMany |
- Species where no ortholog for COL28A1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for COL28A1 Gene
(16) SIMAP similar genes for COL28A1 Gene using alignment to 3 proteins:
Variants for COL28A1 Gene
| SNP ID | Clin | Chr 07 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000011177 | -- | 7,388,905(+) | TTTGT(C/G)AGATG | intron-variant | |
| rs1000016604 | -- | 7,405,633(+) | GGACT(A/T)CTCTC | intron-variant | |
| rs1000025654 | -- | 7,440,403(+) | GCCTT(C/T)CAAAG | intron-variant | |
| rs1000061357 | -- | 7,440,180(+) | TTACC(A/G)GGACA | intron-variant | |
| rs1000068846 | -- | 7,391,090(+) | ATCTT(C/T)CCCAC | intron-variant |
Relevant External Links for COL28A1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- COL28A1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COL28A1 Gene
Disorders for COL28A1 Gene
Relevant External Links for COL28A1
No disorders were found for COL28A1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COL28A1 Gene
Publications for COL28A1 Gene
- Collagen XXVIII, a novel von Willebrand factor A domain-containing protein with many imperfections in the collagenous domain. (PMID: 16330543) Veit G. … Wagener R. (J. Biol. Chem. 2006) 2 3 4 22 64
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
- Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
- Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PMID: 22610502) Kennedy R.B. … Poland G.A. (Hum. Genet. 2012) 3 64
Products for COL28A1 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- OriGene Purified Proteins for COL28A1
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- Browse OriGene Inhibitory RNA Products For COL28A1
- OriGene qPCR primer pairs for COL28A1
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- OriGene ORF clones in human for COL28A1
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- GenScript: Design CRISPR guide RNA sequences for COL28A1
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- CloneReady with Over 120,000 Genes
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- Novus Biologicals Antibodies for COL28A1
- Novus Biologicals proteins for COL28A1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ViGene Biosciences adenoviral particle packaged cDNA for COL28A1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for COL28A1 gene
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- Search ViGene Biosciences for COL28A1
- Horizon Cell Lines for COL28A1
- Cyagen custom Knockout/knockin (KOKI) mouse models for COL28A1
- VectorBuilder custom plasmid, inducible vectors for COL28A1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for COL28A1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for COL28A1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
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- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




