Free for academic non-profit institutions. Other users need a Commercial license

Aliases for COL26A1 Gene

Aliases for COL26A1 Gene

  • Collagen, Type XXVI, Alpha 1 2 3
  • Emilin And Multimerin Domain-Containing Protein 2 3 4
  • EMI Domain Containing 2 2 3
  • EMID2 3 4
  • EMU2 3 4
  • EMI Domain-Containing Protein 2 4
  • Alpha-1 Type XXVI Collagen 4
  • Emu2 Gene 2
  • EMI6 3
  • SH2B 3

External Ids for COL26A1 Gene

Previous HGNC Symbols for COL26A1 Gene

  • EMID2

Previous GeneCards Identifiers for COL26A1 Gene

  • GC07P099489
  • GC07P100552
  • GC07P100566
  • GC07P101007

Summaries for COL26A1 Gene

Entrez Gene Summary for COL26A1 Gene

  • This gene encodes a protein containing an emilin domain and two collagen stretches. This gene may be associated with aspirin-intolerant asthma. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

GeneCards Summary for COL26A1 Gene

COL26A1 (Collagen, Type XXVI, Alpha 1) is a Protein Coding gene. Among its related pathways are Degradation of the extracellular matrix and Collagen biosynthesis and modifying enzymes. An important paralog of this gene is EMID1.

Gene Wiki entry for COL26A1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COL26A1 Gene

Genomics for COL26A1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for COL26A1 Gene

101,362,820 bp from pter
101,559,024 bp from pter
196,205 bases
Plus strand

Genomic View for COL26A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COL26A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COL26A1 Gene

No data available for Regulatory Elements for COL26A1 Gene

Proteins for COL26A1 Gene

  • Protein details for COL26A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Collagen alpha-1(XXVI) chain
    Protein Accession:
    Secondary Accessions:
    • Q32M90

    Protein attributes for COL26A1 Gene

    441 amino acids
    Molecular mass:
    45381 Da
    Quaternary structure:
    • Homotrimer or heterotrimer.

    Three dimensional structures from OCA and Proteopedia for COL26A1 Gene

    Alternative splice isoforms for COL26A1 Gene


neXtProt entry for COL26A1 Gene

Proteomics data for COL26A1 Gene at MOPED

Post-translational modifications for COL26A1 Gene

  • Hydroxylated on proline residues.
  • Glycosylation at Asn 70, Asn 132, Thr 339, Ser 343, and Thr 358
  • Modification sites at PhosphoSitePlus

Other Protein References for COL26A1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for COL26A1 Gene

Domains & Families for COL26A1 Gene

Gene Families for COL26A1 Gene

Protein Domains for COL26A1 Gene

Suggested Antigen Peptide Sequences for COL26A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 collagen-like domains.
  • Contains 2 collagen-like domains.
  • Contains 1 EMI domain.
genes like me logo Genes that share domains with COL26A1: view

Function for COL26A1 Gene

Gene Ontology (GO) - Molecular Function for COL26A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with COL26A1: view
genes like me logo Genes that share phenotypes with COL26A1: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COL26A1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for COL26A1 Gene

Localization for COL26A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COL26A1 Gene

Secreted, extracellular space, extracellular matrix.

Gene Ontology (GO) - Cellular Components for COL26A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005581 collagen trimer IEA --
GO:0005783 endoplasmic reticulum --
GO:0005788 endoplasmic reticulum lumen TAS --
genes like me logo Genes that share ontologies with COL26A1: view

No data available for Subcellular locations from COMPARTMENTS for COL26A1 Gene

Pathways & Interactions for COL26A1 Gene

genes like me logo Genes that share pathways with COL26A1: view

Interacting Proteins for COL26A1 Gene

Selected Interacting proteins: Q96A83-COQA1_HUMAN for COL26A1 Gene via MINT I2D

Gene Ontology (GO) - Biological Process for COL26A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010811 positive regulation of cell-substrate adhesion IEA --
GO:0022617 extracellular matrix disassembly TAS --
GO:0030198 extracellular matrix organization TAS --
GO:0030574 collagen catabolic process TAS --
genes like me logo Genes that share ontologies with COL26A1: view

No data available for SIGNOR curated interactions for COL26A1 Gene

Drugs & Compounds for COL26A1 Gene

(2) Drugs for COL26A1 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aspirin Approved Pharma Channel blocker 971
Citalopram Approved Pharma 485
genes like me logo Genes that share compounds with COL26A1: view

Transcripts for COL26A1 Gene

mRNA/cDNA for COL26A1 Gene

Unigene Clusters for COL26A1 Gene

Collagen, type XXVI, alpha 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COL26A1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COL26A1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
SP1: -

Relevant External Links for COL26A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COL26A1 Gene

mRNA expression in normal human tissues for COL26A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for COL26A1 Gene

This gene is overexpressed in Brain - Cortex (x11.0), Brain - Frontal Cortex (BA9) (x8.3), and Brain - Anterior cingulate cortex (BA24) (x6.3).

Protein differential expression in normal tissues from HIPED for COL26A1 Gene

This gene is overexpressed in Placenta (53.4) and Testis (15.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for COL26A1 Gene

SOURCE GeneReport for Unigene cluster for COL26A1 Gene Hs.654854

genes like me logo Genes that share expression patterns with COL26A1: view

Protein tissue co-expression partners for COL26A1 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for COL26A1 Gene

Orthologs for COL26A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for COL26A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Col26a1 35
  • 81.89 (n)
  • 88.18 (a)
Col26a1 16
Col26a1 36
  • 88 (a)
(Rattus norvegicus)
Mammalia Col26a1 35
  • 81.89 (n)
  • 87.67 (a)
(Bos Taurus)
Mammalia COL26A1 36
  • 89 (a)
(Canis familiaris)
Mammalia COL26A1 36
  • 83 (a)
(Monodelphis domestica)
Mammalia COL26A1 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia COL26A1 36
  • 62 (a)
(Gallus gallus)
Aves EMID2 35
  • 70.21 (n)
  • 72.1 (a)
(Anolis carolinensis)
Reptilia COL26A1 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia col26a1 35
  • 59.59 (n)
  • 59.51 (a)
(Danio rerio)
Actinopterygii COL26A1 36
  • 56 (a)
Species with no ortholog for COL26A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COL26A1 Gene

Gene Tree for COL26A1 (if available)
Gene Tree for COL26A1 (if available)

Paralogs for COL26A1 Gene

Paralogs for COL26A1 Gene

genes like me logo Genes that share paralogs with COL26A1: view

Variants for COL26A1 Gene

Sequence variations from dbSNP and Humsavar for COL26A1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs221 -- 101,381,867(-) TCTCC(A/G)TTTGt intron-variant
rs821 -- 101,381,873(-) TTTTC(A/G)TCTCC intron-variant
rs4045 -- 101,423,808(-) ACTCC(A/G)AGGAG intron-variant
rs868845 -- 101,447,213(+) AGCAA(A/T)TTGGG intron-variant
rs869127 -- 101,448,189(-) AAATA(C/T)GTGGC intron-variant

Variation tolerance for COL26A1 Gene

Residual Variation Intolerance Score: 80.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COL26A1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for COL26A1 Gene

Disorders for COL26A1 Gene

Relevant External Links for COL26A1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with COL26A1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COL26A1 Gene

Publications for COL26A1 Gene

  1. Developmental expression and biochemical characterization of Emu family members. (PMID: 12221002) Leimeister C. … Gessler M. (Dev. Biol. 2002) 2 67
  2. Type XXVI collagen, a new member of the collagen family, is specifically expressed in the testis and ovary. (PMID: 12145293) Sato K. … Nagata K. (J. Biol. Chem. 2002) 2 67
  3. Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. (PMID: 24324551) Deng X. … Seielstad M. (PLoS ONE 2013) 67
  4. Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance. (PMID: 23658023) Soteriou D. … Kimber S.J. (J. Biol. Chem. 2013) 67
  5. Genome-wide pharmacogenomic study of citalopram-induced side effects in STAR*D. (PMID: 22760553) Adkins D.E. … van den Oord E.J. (Transl Psychiatry 2012) 67

Products for COL26A1 Gene

Sources for COL26A1 Gene

Back to Top