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COL26A1 Gene

protein-coding   GIFtS: 47
GCID: GC07P101007

Collagen, Type XXVI, Alpha 1

(Previous name: EMI domain containing 2)
(Previous symbol: EMID2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Collagen, Type XXVI, Alpha 11 2     Collagen Alpha-1(XXVI) Chain2
EMID21 2 3     Putative Emu22
EMI Domain Containing 21 2     Emu23
Emilin And Multimerin Domain-Containing Protein 22 3     Alpha-1 Type XXVI Collagen3
EMU22 3     EMI Domain-Containing Protein 23
SH2B2 5     KIAA12995
Emu2 Gene1     SH2B15
EMI62     

External Ids:    HGNC: 180381   Entrez Gene: 1362272   Ensembl: ENSG000001609637   OMIM: 6089275   UniProtKB: Q96A833   

Export aliases for COL26A1 gene to outside databases

Previous GC identifers: GC07P099489 GC07P100552 GC07P100566


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for COL26A1 Gene:
This gene encodes a protein containing an emilin domain and two collagen stretches. This gene may be associated
with aspirin-intolerant asthma. Alternatively spliced transcript variants encoding different isoforms have been
found for this gene. (provided by RefSeq, Aug 2013)

GeneCards Summary for COL26A1 Gene:
COL26A1 (collagen, type XXVI, alpha 1) is a protein-coding gene. Diseases associated with COL26A1 include asthma, and ataxia. An important paralog of this gene is EMILIN2.

Gene Wiki entry for COL26A1 (EMID2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007933.16  
Regulatory elements:
   Search for regulatory transcription factor binding sites for COL26A1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOL26A1 promoter sequence
   Search Chromatin IP Primers for COL26A1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COL26A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22.1

COL26A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COL26A1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P101007:  view genomic region     (about GC identifiers)

Start:
101,006,101 bp from pter      End:
101,202,304 bp from pter
Size:
196,204 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 100,364,509-100,560,691     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: COQA1_HUMAN, Q96A83 (See protein sequence)
Recommended Name: Collagen alpha-1(XXVI) chain precursor  
Size: 441 amino acids; 45381 Da
Subunit: Homotrimer or heterotrimer (By similarity)
1 PDB 3D structure from and Proteopedia for COL26A1:
4BJ3 (3D)    
Secondary accessions: Q32M90
Alternative splicing: 2 isoforms:  Q96A83-1   Q96A83-2   (May be due to a competing acceptor splice site)

Explore the universe of human proteins at neXtProt for COL26A1: NX_Q96A83

Explore proteomics data for COL26A1 at MOPED

Post-translational modifications: 

  • Hydroxylated on proline residues (By similarity)1
  • Glycosylation2 at Asn70, Asn132, Thr339, Ser343, Thr358
  • Modification sites at PhosphoSitePlus

  • See COL26A1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001265492.1  NP_597714.2  

    ENSEMBL proteins: 
     ENSP00000381022   ENSP00000434167   ENSP00000318234  
    Reactome Protein details: Q96A83

    COL26A1 Human Recombinant Protein Products:

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    LSBio Antibodies in human, mouse, rat for COL26A1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EMID: EMI domain containing
    COLLAGEN: Collagens

    2 InterPro protein domains:
     IPR011489 EMI_domain
     IPR008160 Collagen

    Graphical View of Domain Structure for InterPro Entry Q96A83

    ProtoNet protein and cluster: Q96A83

    2 Blocks protein domains:
    IPB008160 Collagen triple helix repeat
    IPB011489 EMI


    UniProtKB/Swiss-Prot: COQA1_HUMAN, Q96A83
    Similarity: Contains 2 collagen-like domains
    Similarity: Contains 1 EMI domain


    COL26A1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    COL26A1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for COL26A1
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    miRNA
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    miRTarBase miRNAs that target COL26A1:
    hsa-mir-877-3p (MIRT037114), hsa-mir-423-3p (MIRT042612), hsa-mir-484 (MIRT041887)

    Block miRNA regulation of human, mouse, rat COL26A1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate COL26A1
    SwitchGear 3'UTR luciferase reporter plasmidCOL26A1 3' UTR sequence
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    Predesigned siRNA for gene silencing in human, mouse, rat COL26A1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COL26A1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    COQA1_HUMAN, Q96A83: Secreted, extracellular space, extracellular matrix

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix ----
    GO:0005581collagen IEA--
    GO:0005783endoplasmic reticulum ----
    GO:0005788endoplasmic reticulum lumen TAS--

    COL26A1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for COL26A1 About    
    See pathways by source

    SuperPathContained pathways About
    1Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.43
    Extracellular matrix organization0.34
    Collagen degradation0.43
    2Collagen biosynthesis and modifying enzymes
    Collagen biosynthesis and modifying enzymes0.75
    Collagen formation0.75

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for COL26A1
        Collagen biosynthesis and modifying enzymes
    Collagen degradation



    COL26A1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for COL26A1
    Interactions:

        Search GeneGlobe Interaction Network for COL26A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for COL26A1 (Q96A832, 3 ENSP000003810224) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TBPP202262, 3, ENSP000002303544MINT-2878727 I2D: score=3 STRING: ENSP00000230354
    EMID1Q96A843, ENSP000003354814I2D: score=2 STRING: ENSP00000335481
    SERPINH1P504543, ENSP000003508944I2D: score=1 STRING: ENSP00000350894
    COL14A1ENSP000002978484STRING: ENSP00000297848
    COL15A1ENSP000003641404STRING: ENSP00000364140
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010811positive regulation of cell-substrate adhesion ----
    GO:0022617extracellular matrix disassembly TAS--
    GO:0030198extracellular matrix organization TAS--
    GO:0030574collagen catabolic process TAS--

    COL26A1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for COL26A1 (COQA1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for COL26A1 gene (2 alternative transcripts): 
    NM_001278563.1  NM_133457.3  

    Unigene Cluster for COL26A1:

    Collagen, type XXVI, alpha 1
    Hs.654854  [show with all ESTs]
    Unigene Representative Sequence: BC110393
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397927(uc010lhy.1 uc003uyo.1) ENST00000528707 ENST00000473628
    ENST00000313669
    miRNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat COL26A1
      QuantiFast Probe-based Assays in human, mouse, rat COL26A1

    Additional mRNA sequence: 

    AJ416091.1 BC040052.1 BC109254.2 BC110393.1 

    3 DOTS entries:

    DT.97793290  DT.75112846  DT.91993184 

    Selected AceView cDNA sequences (see all 54):

    NM_133457 AA455543 BF223072 BM676006 AJ416091 BU848620 BU845945 T08835 
    BU501936 BM674081 BQ222822 BC040052 BE222745 AW204978 AI049672 BI549609 
    BM712486 AA565531 AI351708 AI815875 BE741432 Z38616 BE908620 AA460834 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for COL26A1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
    SP1:                                                                          -                           
    SP2:                                                                                                      
    SP3:                                                                                                      
    SP4:                                                                                                      


    ECgene alternative splicing isoforms for COL26A1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    COL26A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    COL26A1 Expression
    About this image


    COL26A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Endothelium (Cardiovascular System)
             Mature Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)
             Mature Endothelial Cells Blood Brain Barrier
     
     Ovary (Reproductive System)
    COL26A1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    COL26A1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654854
        Custom PCR Arrays for COL26A1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COL26A1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for COL26A1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Col26a11 , 5 EMI domain containing 25
    collagen, type XXVI, alpha 11
    81.89(n)1
    88.18(a)1
      5 (76.03 cM)5
    1407091  NM_024474.21  NP_077794.21 
     1367417595 
    chicken
    (Gallus gallus)
    Aves EMID21 EMI domain containing 2 70.21(n)
    72.1(a)
      417504  XM_004946473.1  XP_004946530.1 
    lizard
    (Anolis carolinensis)
    Reptilia COL26A16
    collagen, type XXVI, alpha 1
    67(a)
    1 ↔ 1
    GL343613.1(288488-322534)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia col26a11 collagen, type XXVI, alpha 1 59.59(n)
    59.51(a)
      101734784  XM_004911725.1  XP_004911782.1 
    zebrafish
    (Danio rerio)
    Actinopterygii COL26A16
    collagen, type XXVI, alpha 1
    56(a)
    1 ↔ 1
    10(34147144-34192078) ENSDARG00000079330


    ENSEMBL Gene Tree for COL26A1 (if available)
    TreeFam Gene Tree for COL26A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for COL26A1 gene
    EMILIN22  EMILIN12  EMID12  EMILIN32  

    COL26A1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for COL26A1 (see all 5159)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs44241961,2
    C,F,A--101004144(+) TTTGTG/AGAGAT 1 -- us2k14Minor allele frequency- A:0.38NA WA 8
    rs561647651,2
    C,F--101004150(+) GGGGGG/-TCTCA 1 -- us2k12Minor allele frequency- -:0.50NA CSA 4
    rs1845408801,2
    --101004290(+) GGAGTA/GCAGTG 1 -- us2k10--------
    rs1889567161,2
    --101004291(+) GAGTGC/TAGTGG 1 -- us2k10--------
    rs1821811201,2
    --101004314(+) TCACTA/GCAACC 1 -- us2k10--------
    rs1876127711,2
    --101004385(+) CACTAC/GGCCCA 1 -- us2k10--------
    rs77934991,2
    C,F,A--101004484(+) acctcA/Gacttc 1 -- us2k18Minor allele frequency- G:0.50NA WA CSA 133
    rs1902855271,2
    C--101004524(+) ACTGTC/GCCCGG 1 -- us2k10--------
    rs77940151,2
    C,F,A,H--101004539(+) CAAAGC/GATTAG 1 -- us2k115Minor allele frequency- G:0.15NS EA WA NA CSA 789
    rs794591551,2
    F--101004565(+) CCATTA/GCCACT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for COL26A1 (101006101 - 101202304 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for COL26A1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing COL26A1
    DNA2.0 Custom Variant and Variant Library Synthesis for COL26A1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608927    OMIM disorders: --

    3 diseases for COL26A1:    
    About MalaCards
    asthma    ataxia    endotheliitis


    COL26A1 for disorders           About GeneDecksing


    Export disorders for COL26A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for COL26A1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with COL26A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Developmental expression and biochemical characterization of Emu family members. (PubMed id 12221002)1, 2, 3 Leimeister C.... Gessler M. (Dev. Biol. 2002)
    2. Type XXVI collagen, a new member of the collagen family, is specifically expressed in the testis and ovary. (PubMed id 12145293)1, 3 Sato K....Nagata K. (J. Biol. Chem. 2002)
    3. Genome-wide pharmacogenomic study of citalopram-induced side effects in STAR*D. (PubMed id 22760553)1 Adkins D.E....van den Oord E.J. (Transl Psychiatry 2012)
    4. Possible role of EMID2 on nasal polyps pathogenesis in Korean asthma patients. (PubMed id 22217332)1 Pasaje C.F....Shin H.D. (BMC Med. Genet. 2012)
    5. A possible association of EMID2 polymorphisms with aspirin hypersensitivity in asthma. (PubMed id 21086123)1 Pasaje C.F....Shin H.D. (Immunogenetics 2011)
    6. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (Cell 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (Nature 2003)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Toward a complete human genome sequence. (PubMed id 9847074)1 Sulston J.E. and Waterston R. (Genome Res. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 136227 HGNC: 18038 AceView: EMID2 Ensembl:ENSG00000160963 euGenes: HUgn136227
    ECgene: COL26A1 H-InvDB: COL26A1

    (According to HUGE)
    About This Section

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    HUGE: KIAA1299

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for COL26A1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for COL26A1 gene:
    Search GeneIP for patents involving COL26A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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