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Aliases for COL26A1 Gene

Aliases for COL26A1 Gene

  • Collagen Type XXVI Alpha 1 2 3
  • Collagen, Type XXVI, Alpha 1 2 3 5
  • Emilin And Multimerin Domain-Containing Protein 2 3 4
  • EMI Domain Containing 2 2 3
  • EMID2 3 4
  • EMU2 3 4
  • EMI Domain-Containing Protein 2 4
  • Alpha-1 Type XXVI Collagen 4
  • Emu2 Gene 2
  • EMI6 3
  • SH2B 3

External Ids for COL26A1 Gene

Previous HGNC Symbols for COL26A1 Gene

  • EMID2

Previous GeneCards Identifiers for COL26A1 Gene

  • GC07P099489
  • GC07P100552
  • GC07P100566
  • GC07P101007

Summaries for COL26A1 Gene

Entrez Gene Summary for COL26A1 Gene

  • This gene encodes a protein containing an emilin domain and two collagen stretches. This gene may be associated with aspirin-intolerant asthma. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

GeneCards Summary for COL26A1 Gene

COL26A1 (Collagen Type XXVI Alpha 1) is a Protein Coding gene. Among its related pathways are Degradation of the extracellular matrix and Collagen biosynthesis and modifying enzymes. An important paralog of this gene is EMID1.

Gene Wiki entry for COL26A1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COL26A1 Gene

Genomics for COL26A1 Gene

Regulatory Elements for COL26A1 Gene

Promoters for COL26A1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around COL26A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for COL26A1 Gene

Chromosome:
7
Start:
101,362,820 bp from pter
End:
101,559,024 bp from pter
Size:
196,205 bases
Orientation:
Plus strand

Genomic View for COL26A1 Gene

Genes around COL26A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COL26A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COL26A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COL26A1 Gene

Proteins for COL26A1 Gene

  • Protein details for COL26A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A83-COQA1_HUMAN
    Recommended name:
    Collagen alpha-1(XXVI) chain
    Protein Accession:
    Q96A83
    Secondary Accessions:
    • Q32M90

    Protein attributes for COL26A1 Gene

    Size:
    441 amino acids
    Molecular mass:
    45381 Da
    Quaternary structure:
    • Homotrimer or heterotrimer.

    Three dimensional structures from OCA and Proteopedia for COL26A1 Gene

    Alternative splice isoforms for COL26A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COL26A1 Gene

Proteomics data for COL26A1 Gene at MOPED

Post-translational modifications for COL26A1 Gene

  • Hydroxylated on proline residues.
  • Glycosylation at Asn 70, Asn 132, Thr 339, Ser 343, and Thr 358
  • Modification sites at PhosphoSitePlus

Other Protein References for COL26A1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for COL26A1 Gene

Domains & Families for COL26A1 Gene

Gene Families for COL26A1 Gene

Protein Domains for COL26A1 Gene

Suggested Antigen Peptide Sequences for COL26A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96A83

UniProtKB/Swiss-Prot:

COQA1_HUMAN :
  • Contains 2 collagen-like domains.
Domain:
  • Contains 2 collagen-like domains.
  • Contains 1 EMI domain.
genes like me logo Genes that share domains with COL26A1: view

Function for COL26A1 Gene

genes like me logo Genes that share phenotypes with COL26A1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for COL26A1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for COL26A1 Gene

Localization for COL26A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COL26A1 Gene

Secreted, extracellular space, extracellular matrix.

Gene Ontology (GO) - Cellular Components for COL26A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with COL26A1: view

No data available for Subcellular locations from COMPARTMENTS for COL26A1 Gene

Pathways & Interactions for COL26A1 Gene

genes like me logo Genes that share pathways with COL26A1: view

Interacting Proteins for COL26A1 Gene

Selected Interacting proteins: Q96A83-COQA1_HUMAN for COL26A1 Gene via I2D MINT

Gene Ontology (GO) - Biological Process for COL26A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022617 extracellular matrix disassembly TAS --
GO:0030574 collagen catabolic process TAS --
genes like me logo Genes that share ontologies with COL26A1: view

No data available for SIGNOR curated interactions for COL26A1 Gene

Drugs & Compounds for COL26A1 Gene

(2) Drugs for COL26A1 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aspirin Approved Pharma Channel blocker 1029
Citalopram Approved Pharma 494
genes like me logo Genes that share compounds with COL26A1: view

Transcripts for COL26A1 Gene

mRNA/cDNA for COL26A1 Gene

Unigene Clusters for COL26A1 Gene

Collagen, type XXVI, alpha 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COL26A1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b
SP1: -
SP2:
SP3:
SP4:

Relevant External Links for COL26A1 Gene

GeneLoc Exon Structure for
COL26A1
ECgene alternative splicing isoforms for
COL26A1

Expression for COL26A1 Gene

mRNA expression in normal human tissues for COL26A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for COL26A1 Gene

This gene is overexpressed in Brain - Cortex (x11.0), Brain - Frontal Cortex (BA9) (x8.3), and Brain - Anterior cingulate cortex (BA24) (x6.3).

Protein differential expression in normal tissues from HIPED for COL26A1 Gene

This gene is overexpressed in Placenta (53.4) and Testis (15.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for COL26A1 Gene



SOURCE GeneReport for Unigene cluster for COL26A1 Gene Hs.654854

genes like me logo Genes that share expression patterns with COL26A1: view

Protein tissue co-expression partners for COL26A1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for COL26A1 Gene

Orthologs for COL26A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for COL26A1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia COL26A1 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COL26A1 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Col26a1 16
Col26a1 36
  • 88 (a)
OneToOne
Col26a1 35
  • 81.89 (n)
  • 88.18 (a)
oppossum
(Monodelphis domestica)
Mammalia COL26A1 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COL26A1 36
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Col26a1 35
  • 81.89 (n)
  • 87.67 (a)
chicken
(Gallus gallus)
Aves EMID2 35
  • 70.21 (n)
  • 72.1 (a)
lizard
(Anolis carolinensis)
Reptilia COL26A1 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia col26a1 35
  • 59.59 (n)
  • 59.51 (a)
zebrafish
(Danio rerio)
Actinopterygii COL26A1 36
  • 56 (a)
OneToOne
Species with no ortholog for COL26A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COL26A1 Gene

ENSEMBL:
Gene Tree for COL26A1 (if available)
TreeFam:
Gene Tree for COL26A1 (if available)

Paralogs for COL26A1 Gene

Paralogs for COL26A1 Gene

genes like me logo Genes that share paralogs with COL26A1: view

Variants for COL26A1 Gene

Sequence variations from dbSNP and Humsavar for COL26A1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs17471501 - 101,557,485(+) GGGCC(C/T)GACCC reference, synonymous-codon
rs221 -- 101,381,867(-) TCTCC(A/G)TTTGt intron-variant
rs821 -- 101,381,873(-) TTTTC(A/G)TCTCC intron-variant
rs4045 -- 101,423,808(-) ACTCC(A/G)AGGAG intron-variant
rs883910 -- 101,469,440(-) CACCC(C/T)GTTTA intron-variant

Variation tolerance for COL26A1 Gene

Residual Variation Intolerance Score: 80.4% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COL26A1 Gene

HapMap Linkage Disequilibrium report
COL26A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for COL26A1 Gene

Disorders for COL26A1 Gene

Relevant External Links for COL26A1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COL26A1

No disorders were found for COL26A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COL26A1 Gene

Publications for COL26A1 Gene

  1. Developmental expression and biochemical characterization of Emu family members. (PMID: 12221002) Leimeister C. … Gessler M. (Dev. Biol. 2002) 2 3 4 67
  2. Type XXVI collagen, a new member of the collagen family, is specifically expressed in the testis and ovary. (PMID: 12145293) Sato K. … Nagata K. (J. Biol. Chem. 2002) 2 3
  3. Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance. (PMID: 23658023) Soteriou D. … Kimber S.J. (J. Biol. Chem. 2013) 3
  4. Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. (PMID: 24324551) Deng X. … Seielstad M. (PLoS ONE 2013) 3
  5. Possible role of EMID2 on nasal polyps pathogenesis in Korean asthma patients. (PMID: 22217332) Pasaje C.F. … Shin H.D. (BMC Med. Genet. 2012) 3

Products for COL26A1 Gene

Sources for COL26A1 Gene

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