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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

COL25A1 Gene

protein-coding   GIFtS: 54
GCID: GC04M109731

collagen, type XXV, alpha 1
 Explore 5 diseases affiliated with
COL25A1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for COL25A1    

Aliases
for COL25A1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Collagen, Type XXV, Alpha 11 2     CLACP2
Alzheimer Disease Amyloid-Associated Protein2 3     Collagen Alpha-1(XXV) Chain2
AMY2 3     Collagen-Like Alzheimer Amyloid Plaque Component2
CLAC-P2 3     Collagenous Alzheimer Amyloid Plaque Component2
CLAC2 5     

External Ids:    HGNC: 186031   Entrez Gene: 845702   Ensembl: ENSG000001885177   OMIM: 6100045   UniProtKB: Q9BXS03   

Export aliases for COL25A1 gene to outside databases

Previous GC identifers: GC04M110125 GC04M110203 GC04M110193 GC04M110092 GC04M109954 GC04M105467


Summaries
for COL25A1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for COL25A1:
This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded
protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer
amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of
over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded
protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Dec 2011)

UniProtKB/Swiss-Prot: COPA1_HUMAN, Q9BXS0
Function: Inhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to assemble
amyloid fibrils into protease-resistant aggregates. Binds heparin

Gene Wiki entry for COL25A1 (Collagen, type XXV, alpha 1)


Genomic Views
for COL25A1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the COL25A1 gene promoter:
         C/EBPbeta   NF-1/L   NF-1   FOXF2   MyoD   MIF-1   POU2F1   E2F-1   E2F   HFH-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: COL25A1 promoter sequence
   Search SABiosciences Chromatin IP Primers for COL25A1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COL25A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q25   Ensembl cytogenetic band:  4q25   HGNC cytogenetic band: 4q25

COL25A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COL25A1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M109731:  view genomic region     (about GC identifiers)

Start:
 109,731,877 bp from pter      End:
 110,223,813 bp from pter
Size:
 491,937 bases      Orientation:
 minus strand

Proteins
for COL25A1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: COPA1_HUMAN, Q9BXS0 (See protein sequence)
Recommended Name: Collagen alpha-1(XXV) chain  
Size: 654 amino acids; 64771 Da
Subunit: Forms homodimers and homotrimers. Binds to the fibrillized forms of beta amyloid peptide 40 (beta-APP40) and
beta amyloid peptide 42 (beta-APP42). Found associated with beta-APP42 more frequently than with beta-APP40
Subcellular location: Membrane; Single-pass type II membrane protein (Potential). Note=After proteolytic cleavage, CLAC
is secreted
Caution: The pyrrolidone carboxylic acid reported in PubMed:11927537 probably formed artifactually from Glu-113 during
the extraction procedure in 70% formic acid. In PubMed:15522881, the protein was found to have unblocked Glu at the
N-terminus
Secondary accessions: A8MPZ6 Q9BXR9
Alternative splicing: 3 isoforms:  Q9BXS0-1   Q9BXS0-2   Q9BXS0-3   

Explore the universe of human proteins at neXtProt for COL25A1: NX_Q9BXS0

Post-translational modifications:

  • Undergoes proteolytic cleavage by furin protease to yield the soluble collagen-like Alzheimer amyloid plaque component1
  • Glycosylated1
  • Hydroxylated on 11% of proline residues and 49% of lysine residues1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BXS0

    • COL25A1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001243003.1  NP_115907.2  NP_942014.1  

    ENSEMBL proteins: 
     ENSP00000437131   ENSP00000426841   ENSP00000382083   ENSP00000382078   ENSP00000382077  
     ENSP00000422266  
    Reactome Protein details: Q9BXS0
    Human Recombinant Protein Products: 
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    Novus Biologicals COL25A1 Proteins
    Novus Biologicals COL25A1 Lysates
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IDA11927537
    GO:0005581collagen IEA--
    GO:0005615extracellular space IDA11927537
    GO:0005788endoplasmic reticulum lumen TAS--
    GO:0005886plasma membrane TAS--


    COL25A1 for ontologies           About GeneDecksing



    COL25A1 Antibody Products: 
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    Protein Domains /
    Families
    for COL25A1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    COL25A1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR008160 Collagen

    Graphical View of Domain Structure for InterPro Entry Q9BXS0

    ProtoNet protein and cluster: Q9BXS0

    2 Blocks protein families:
    IPB008160 Collagen triple helix repeat
    IPB008161 Collagen helix repeat


    UniProtKB/Swiss-Prot: COPA1_HUMAN, Q9BXS0
    Similarity: Contains 7 collagen-like domains


    Function
    for COL25A1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: COPA1_HUMAN, Q9BXS0
    Function: Inhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to assemble
    amyloid fibrils into protease-resistant aggregates. Binds heparin

    miRNA
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    hsa-miR-30c hsa-miR-30a hsa-miR-376a* hsa-miR-30b hsa-miR-30d hsa-miR-30e hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmid: COL25A1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for COL25A1

    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001540beta-amyloid binding IDA11927537
    GO:0008201heparin binding IDA15522881


    COL25A1 for ontologies           About GeneDecksing



    Pathways & Interactions
    for COL25A1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Integrin Pathway
    		Integrin Pathway1.00
    		UPA-UPAR Pathway0.51
    		FAK1 Signaling0.67
    		Transendothelial Migration of Leukocytes0.38
    		GnRH Signaling0.56
    		Inhibition of Angiogenesis by TSP10.37
    2Rho Family GTPases
    		Rho Family GTPases1.00
    		MAPK Signaling0.51
    		ERK Signaling0.61
    		ILK Signaling0.45
    		Molecular Mechanisms of Cancer0.51
    3Collagen formation
    		Collagen formation1.00
    		Extracellular matrix organization0.54
    		Collagen biosynthesis and modifying enzymes0.74
    4Degradation of the extracellular matrix
    		Degradation of the extracellular matrix1.00
    		Degradation of collagen0.79
    5Blood Coagulation Cascade
    		Blood Coagulation Cascade1.00
    		Intrinsic Prothrombin Activation Pathway0.96

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for COL25A1 (see all 15)
        MAPK Signaling
    Molecular Mechanisms of Cancer
    PTEN Pathway
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway

    5/6        Reactome Pathways for COL25A1 (see all 6)
        Secretion of transmembrane collagens
    Extracellular matrix organization
    Collagen biosynthesis and modifying enzymes
    Degradation of the extracellular matrix
    Collagen formation



    COL25A1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for COL25A1

    3 Interacting proteins for COL25A1 (Q9BXS03) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APPP050673I2D: score=2 
    IAPPP109973I2D: score=1 
    SNCAP378403I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030198extracellular matrix organization TAS--


    COL25A1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for COL25A1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for COL25A1
    Search CenterWatch for drugs/clinical trials and news about COL25A1 / COPA1 

    Transcripts
    for COL25A1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for COL25A1 gene (3 alternative transcripts): 
    NM_001256074.1  NM_032518.2  NM_198721.2  

    Unigene Cluster for COL25A1:

    Collagen, type XXV, alpha 1
    Hs.658842  [show with all ESTs]
    Unigene Representative Sequence: NM_198721
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000494183(uc003hzd.3 uc021xqo.1 uc003hze.1) ENST00000512961
    ENST00000399132 ENST00000399127(uc003hzf.3 uc003hzh.1) ENST00000399126(uc021xqp.1 uc003hzg.3)
    ENST00000505377 ENST00000505591

    miRNA
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    hsa-miR-30c hsa-miR-30a hsa-miR-376a* hsa-miR-30b hsa-miR-30d hsa-miR-30e hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmid: COL25A1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COL25A1 (see all 4)
    OriGene shRNA RFP: COL25A1
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COL25A1
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): COL25A1 (NM_032518)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COL25A1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COL25A1 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COL25A1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COL25A1

    Additional cDNA sequence: 

    AF293340.1 AF293341.1 AK095098.1 BC030649.1 BC036669.2 CR627107.1 NR_045756.2 

    8 DOTS entries:

    DT.95318910  DT.99941487  DT.40221035  DT.95246709  DT.75192581  DT.91979426  DT.70101367  DT.121236608 

    24/32 AceView cDNA sequences (see all 32):

    BX281385 AL699546 AL044634 BE350246 AA487300 AW182698 BI463519 BQ438165 
    BC030649 AK095098 BF969735 NM_198721 AW298437 AF293340 BC036669 AF293341 
    NM_032518 AL701103 CR627107 AW769796 BE727467 BI223627 AI657100 BF589778 

    GeneLoc Exon Structure


    Expression
    for COL25A1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    COL25A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCCCTGCAGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    COL25A1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayernGnG Amacrine CellsAmacrine, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See COL25A1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for COL25A1

    SOURCE GeneReport for Unigene cluster: Hs.658842

    UniProtKB/Swiss-Prot: COPA1_HUMAN, Q9BXS0
    Tissue specificity: Expressed predominantly in brain. Deposited preferentially in primitive or neuritic amyloid plaques
    which are typical of Alzheimer disease

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    In Situ
    Assay Products:     
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    Orthologs
    for COL25A1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for COL25A1 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves COL25A11 collagen, type XXV, alpha 1 78.71(n)
    83.72(a)    		   429900  XM_427455.3  XP_427455.3 
    lizard
    (Anolis carolinensis)    		 Reptilia COL25A16
    		 --
    		 86(a)
    		 1 ↔ 1
    		 5(144919423-145008431)
    worm
    (Caenorhabditis elegans)    		 Secernentea col-996
    		 Putative cuticle collagen 99
    		 25(a)
    		 1 ↔ 1
    		 IV(138461-147919)


    ENSEMBL Gene Tree for COL25A1 (if available)
    TreeFam Gene Tree for COL25A1 (if available) 

    Paralogs
    for COL25A1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for COL25A1 gene
    COL13A12  COL23A12  
    5 SIMAP similar genes for COL25A1 using alignment to 7 protein entries:     COPA1_HUMAN (see all proteins):
    SCARA5    COL6A2    FCN2    COL28A1    GLDN

    COL25A1 for paralogs           About GeneDecksing



    Genomic Variants
    for COL25A1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for COL25A1
         3 CNVs: 51216 98840 68783
         2 Indels: 68782 63142
    Human Gene Mutation Database (HGMD): COL25A1
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COL25A1
    DNA2.0 Custom Variant and Variant Library Synthesis for COL25A1

    Disorders / Diseases
    for COL25A1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    COL25A1 for disorders           About GeneDecksing

    OMIM gene information: 610004    OMIM disorders: --

    5 diseases for COL25A1:    About MalaCards
    alzheimer's disease    systemic lupus erythematosus    lupus erythematosus    alcohol dependence
    alcoholism

    Human Genome Epidemiology (HuGE) Navigator: COL25A1 (4 documents)

    Export disorders for COL25A1 gene to outside databases

    Publications
    for COL25A1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for COL25A1 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with COL25A1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV. (PubMed id 11927537)1, 2, 3, 9 Hashimoto T.... Iwatsubo T. (2002)
    2. Molecular identification of AMY, an Alzheimer disease amyloid- associated protein. (PubMed id 14656069)1, 2, 9 Soederberg L.... Naeslund J. (2003)
    3. Characterization of the Alzheimer's disease-associated CLAC protein and identification of an amyloid beta-peptide-binding site. (PubMed id 15522881)1, 2 Soederberg L.... Naeslund J. (2005)
    4. CLAC binds to aggregated Abeta and Abeta fragments, and attenuates fibril elongation. (PubMed id 16300410)1, 2 Kakuyama H.... Tjernberg L.O. (2005)
    5. CLAC binds to amyloid beta peptides through the positively charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils. (PubMed id 15615705)1, 2 Osada Y....Iwatsubo T. (2005)
    6. Collagenous Alzheimer amyloid plaque component assembles amyloid fibrils into protease resistant aggregates. (PubMed id 15853808)1, 2 Soederberg L.... Tjernberg L.O. (2005)
    7. Mostly separate distributions of CLAC- versus Abeta40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid deposits. (PubMed id 15215182)1, 2 Kowa H.... Iwatsubo T. (2004)
    8. Genetic association to the amyloid plaque associated protein gene COL25A1 in Alzheimer's disease. (PubMed id 18501477)1, 9 Forsell C....Graff C. (2008)
    9. Association of COL25A1 with comorbid antisocial person ality disorder and substance dependence. (PubMed id 22297151)1 Li D....Gelernter J. (2012)
    10. Genome-wide association analysis of age at onset in s chizophrenia in a European-American sample. (PubMed id 21688384)1 Wang K.S....Pan Y. (2011)

    External Searches for COL25A1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing COL25A1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84570 HGNC: 18603 AceView: COL25A1 Ensembl:ENSG00000188517 euGenes: HUgn84570
    ECgene: COL25A1 H-InvDB: COL25A1

    Other Databases showing COL25A1 gene

    (According to HUGE)
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    Specialized Databases showing COL25A1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for COL25A1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for COL25A1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for COL25A1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    		Patent Information for COL25A1 gene:
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