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COL25A1 Gene

protein-coding   GIFtS: 54
GCID: GC04M109731

Collagen, Type XXV, Alpha 1

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Collagen, Type XXV, Alpha 11 2     CLACP2
Alzheimer Disease Amyloid-Associated Protein2 3     Collagen Alpha-1(XXV) Chain2
AMY2 3     Collagen-Like Alzheimer Amyloid Plaque Component2
CLAC-P2 3     Collagenous Alzheimer Amyloid Plaque Component2
CLAC2 5     

External Ids:    HGNC: 186031   Entrez Gene: 845702   Ensembl: ENSG000001885177   OMIM: 6100045   UniProtKB: Q9BXS03   

Export aliases for COL25A1 gene to outside databases

Previous GC identifers: GC04M110125 GC04M110203 GC04M110193 GC04M110092 GC04M109954 GC04M105467


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for COL25A1 Gene:
This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the
encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in
Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A
study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting
that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Dec 2011)

GeneCards Summary for COL25A1 Gene:
COL25A1 (collagen, type XXV, alpha 1) is a protein-coding gene. Diseases associated with COL25A1 include alzheimer's disease, and antisocial personality disorder. GO annotations related to this gene include heparin binding and beta-amyloid binding. An important paralog of this gene is COL19A1.

UniProtKB/Swiss-Prot: COPA1_HUMAN, Q9BXS0
Function: Inhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to
assemble amyloid fibrils into protease-resistant aggregates. Binds heparin

Gene Wiki entry for COL25A1 (Collagen, type XXV, alpha 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the COL25A1 gene promoter:
         C/EBPbeta   NF-1/L   NF-1   FOXF2   MyoD   MIF-1   POU2F1   E2F-1   E2F   HFH-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOL25A1 promoter sequence
   Search Chromatin IP Primers for COL25A1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COL25A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q25   Ensembl cytogenetic band:  4q25   HGNC cytogenetic band: 4q25

COL25A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COL25A1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M109731:  view genomic region     (about GC identifiers)

Start:
109,731,877 bp from pter      End:
110,223,813 bp from pter
Size:
491,937 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: COPA1_HUMAN, Q9BXS0 (See protein sequence)
Recommended Name: Collagen alpha-1(XXV) chain  
Size: 654 amino acids; 64771 Da
Subunit: Forms homodimers and homotrimers. Binds to the fibrillized forms of beta amyloid peptide 40 (beta-APP40)
and beta amyloid peptide 42 (beta-APP42). Found associated with beta-APP42 more frequently than with beta-APP40
Caution: The pyrrolidone carboxylic acid reported in PubMed:11927537 probably formed artifactually from Glu-113
during the extraction procedure in 70% formic acid. In PubMed:15522881, the protein was found to have unblocked
Glu at the N-terminus
Secondary accessions: A8MPZ6 Q9BXR9
Alternative splicing: 3 isoforms:  Q9BXS0-1   Q9BXS0-2   Q9BXS0-3   

Explore the universe of human proteins at neXtProt for COL25A1: NX_Q9BXS0

Explore proteomics data for COL25A1 at MOPED

Post-translational modifications: 

  • Undergoes proteolytic cleavage by furin protease to yield the soluble collagen-like Alzheimer amyloid plaque
    component1
  • Glycosylated1
  • Hydroxylated on 11% of proline residues and 49% of lysine residues1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See COL25A1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001243003.1  NP_115907.2  NP_942014.1  

    ENSEMBL proteins: 
     ENSP00000437131   ENSP00000426841   ENSP00000382083   ENSP00000382078   ENSP00000382077  
     ENSP00000422266  
    Reactome Protein details: Q9BXS0

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    COLLAGEN: Collagens

    1 InterPro protein domain:
     IPR008160 Collagen

    Graphical View of Domain Structure for InterPro Entry Q9BXS0

    ProtoNet protein and cluster: Q9BXS0

    2 Blocks protein domains:
    IPB008160 Collagen triple helix repeat
    IPB008161 Collagen helix repeat


    UniProtKB/Swiss-Prot: COPA1_HUMAN, Q9BXS0
    Similarity: Contains 7 collagen-like domains


    COL25A1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COPA1_HUMAN, Q9BXS0
    Function: Inhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to
    assemble amyloid fibrils into protease-resistant aggregates. Binds heparin

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001540beta-amyloid binding IDA11927537
    GO:0008201heparin binding IDA15522881
         
    COL25A1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for COL25A1
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    7 qRT-PCR Assays for microRNAs that regulate COL25A1:
    hsa-miR-30c hsa-miR-30a hsa-miR-376a* hsa-miR-30b hsa-miR-30d hsa-miR-30e hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmidCOL25A1 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COL25A1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    COPA1_HUMAN, Q9BXS0: Membrane; Single-pass type II membrane protein (Potential). Note=After proteolytic cleavage,
    CLAC is secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    endoplasmic reticulum4
    cytosol2
    mitochondrion2
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005581collagen IEA--
    GO:0005615extracellular space IDA11927537
    GO:0005788endoplasmic reticulum lumen TAS--
    GO:0005886plasma membrane TAS--

    COL25A1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for COL25A1 About    
    See pathways by source

    SuperPathContained pathways About
    1Collagen biosynthesis and modifying enzymes
    Collagen biosynthesis and modifying enzymes0.75
    Intrinsic Prothrombin Activation Pathway0.39
    Collagen formation0.75
    Blood Coagulation Cascade0.38
    2Integrin Pathway
    FAK1 Signaling0.67
    UPA-UPAR Pathway0.56
    Integrin Pathway0.67
    Inhibition of Angiogenesis by TSP10.50
    GnRH Signaling0.56
    Transendothelial Migration of Leukocytes0.38
    3ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    4Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.43
    Extracellular matrix organization0.34
    Collagen degradation0.43
    5Phospholipase-C Pathway
    Phospholipase-C Pathway0.56
    PTEN Pathway0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for COL25A1 (see all 15)
        MAPK Signaling
    Molecular Mechanisms of Cancer
    PTEN Pathway
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway

    2 Reactome Pathways for COL25A1
        Collagen biosynthesis and modifying enzymes
    Collagen degradation



    COL25A1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for COL25A1
    Interactions:

        GeneGlobe Interaction Network for COL25A1

    3 Interacting proteins for COL25A1 (Q9BXS03) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APPP050673I2D: score=2 
    IAPPP109973I2D: score=1 
    SNCAP378403I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0022617extracellular matrix disassembly TAS--
    GO:0030198extracellular matrix organization TAS--
    GO:0030574collagen catabolic process TAS--

    COL25A1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for COL25A1 (COPA1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for COL25A1 gene (3 alternative transcripts): 
    NM_001256074.1  NM_032518.2  NM_198721.3  

    Unigene Cluster for COL25A1:

    Collagen, type XXV, alpha 1
    Hs.658842  [show with all ESTs]
    Unigene Representative Sequence: NM_198721
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000494183(uc003hzd.3 uc021xqo.1 uc003hze.1) ENST00000512961
    ENST00000399132 ENST00000399127(uc003hzf.3 uc003hzh.1) ENST00000399126(uc021xqp.1 uc003hzg.3)
    ENST00000505377 ENST00000505591

    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate COL25A1:
    hsa-miR-30c hsa-miR-30a hsa-miR-376a* hsa-miR-30b hsa-miR-30d hsa-miR-30e hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmidCOL25A1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat COL25A1
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    GenScript: all cDNA clones in your preferred vector (see all 2): COL25A1 (NM_032518)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COL25A1
    Primer
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    OriGene qPCR primer pairs and template standards for COL25A1
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      QuantiTect SYBR Green Assays in human, mouse, rat COL25A1
      QuantiFast Probe-based Assays in human, mouse, rat COL25A1

    Additional mRNA sequence: 

    AF293340.1 AF293341.1 AK095098.1 BC030649.1 BC036669.2 CR627107.1 NR_045756.2 

    8 DOTS entries:

    DT.95318910  DT.99941487  DT.40221035  DT.95246709  DT.75192581  DT.91979426  DT.70101367  DT.121236608 

    Selected AceView cDNA sequences (see all 32):

    BE350246 BX281385 AL699546 AW182698 AA487300 AL044634 BF969735 AK095098 
    BC030649 NM_198721 BQ438165 AF293340 AW769796 NM_032518 AF293341 BC036669 
    CR627107 BI463519 AL701103 AW298437 BE727467 BI223627 AI657100 BU688263 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    COL25A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCTGCAGG
    COL25A1 Expression
    About this image


    COL25A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Ureteric Bud Cells Ureteric Bud
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Neurons
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Testis (Reproductive System)
    COL25A1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    COL25A1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.658842

    UniProtKB/Swiss-Prot: COPA1_HUMAN, Q9BXS0
    Tissue specificity: Expressed predominantly in brain. Deposited preferentially in primitive or neuritic amyloid
    plaques which are typical of Alzheimer disease

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COL25A1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for COL25A1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Col25a11 , 5 collagen, type XXV, alpha 11, 5 89.19(n)1
    92.51(a)1
      3 (59.99 cM)5
    770181  NM_029838.41  NP_084114.21 
     1301808915 
    chicken
    (Gallus gallus)
    Aves COL25A11 collagen, type XXV, alpha 1 79.61(n)
    85.1(a)
      429900  XM_427455.4  XP_427455.4 
    lizard
    (Anolis carolinensis)
    Reptilia COL25A16
    collagen, type XXV, alpha 1
    86(a)
    1 ↔ 1
    5(144919423-145008819)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia col25a1.21 collagen, type XXV, alpha 1, gene 2 75.75(n)
    80.4(a)
      100170495  NM_001130275.1  NP_001123747.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018827641 collagen alpha-1(XXV) chain-like 68.37(n)
    70.13(a)
      101882764  XM_005166542.1  XP_005166599.1 
    worm
    (Caenorhabditis elegans)
    Secernentea col-1356
    Protein COL-135, isoform a (col-135) mRNA, complet...
    33(a)
    1 → many
    IV(15129662-15131786) WBGene00000708


    ENSEMBL Gene Tree for COL25A1 (if available)
    TreeFam Gene Tree for COL25A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for COL25A1 gene
    COL19A12  COL9A12  COL22A12  COL13A12  COL9A32  COL9A22  COL16A12  COL21A12  
    COL23A12  
    4 SIMAP similar genes for COL25A1 using alignment to 7 protein entries:     COPA1_HUMAN (see all proteins):
    COL6A2    FCN2    COL28A1    GLDN

    COL25A1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for COL25A1 (see all 9920)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs671730001,2
    C--105615162(+) TTCTC-/CTGTT 
            
    CTGTT
    4 -- int12Minor allele frequency- CTGTT:0.25NA CSA 4
    rs611954621,2
    C--105803951(+) GTGTG-/GGTGTGT 4 -- int11Minor allele frequency- GG:0.00NA 2
    rs131372531,2
    H--109731450(+) ACAATT/ATTCTA 2 -- ds50014Minor allele frequency- A:0.00NS EA 418
    rs76668531,2
    C,F--109731468(+) ACATAT/GGTCTA 2 -- ds50017Minor allele frequency- G:0.33WA NA CSA EA 365
    rs1512630571,2
    C--109731515(+) AACTAA/GTTGAT 2 -- ds50010--------
    rs76888411,2
    C,F,A--109731559(+) ATGCAC/GAGAAT 2 -- ds50018Minor allele frequency- G:0.46NA CSA WA EA 368
    rs76893461,2
    C,F,A--109731593(+) CTTCTG/AGTAGG 2 -- ds50017Minor allele frequency- A:0.46NA CSA WA EA 366
    rs131105731,2
    C,F--109731793(+) AAAGAC/TGAGTG 2 -- ds50018Minor allele frequency- T:0.46NA CSA WA EA 368
    rs1883089871,2
    --109731854(+) AATGAA/GTATGA 2 -- ds50010--------
    rs74406261,2
    C,F,A--109731861(+) ATGAAA/GTAGGA 2 -- ds50018Minor allele frequency- G:0.46NA CSA WA EA 368

    HapMap Linkage Disequilibrium report for COL25A1 (109731877 - 109981877 bp, first 250kb of COL25A1)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for COL25A1 (see all 25):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2728124CNV Deletion23290073
    esv2664386CNV Deletion23128226
    esv2657117CNV Deletion23128226
    esv2728125CNV Deletion23290073
    esv2728123CNV Deletion23290073
    nsv293715CNV Insertion16902084
    esv273723CNV Insertion20981092
    esv269886CNV Insertion20981092
    nsv4459CNV Insertion18451855
    esv268533CNV Insertion20981092

    Human Gene Mutation Database (HGMD): COL25A1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing COL25A1
    DNA2.0 Custom Variant and Variant Library Synthesis for COL25A1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610004    OMIM disorders: --

    10 diseases for COL25A1:    
    About MalaCards
    alzheimer's disease    antisocial personality disorder    substance dependence    personality disorder
    cervical intraepithelial neoplasia    alcohol dependence    systemic lupus erythematosus    lupus erythematosus
    cervicitis    schizophrenia


    COL25A1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): COL25A1
    Human Genome Epidemiology (HuGE) Navigator: COL25A1 (4 documents)

    Export disorders for COL25A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for COL25A1 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with COL25A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV. (PubMed id 11927537)1, 2, 3, 9 Hashimoto T.... Iwatsubo T. (EMBO J. 2002)
    2. Genetic association to the amyloid plaque associated protein gene COL25A1 in Alzheimer's disease. (PubMed id 18501477)1, 4, 9 Forsell C....Graff C. (Neurobiol. Aging 2010)
    3. Molecular identification of AMY, an Alzheimer disease amyloid- associated protein. (PubMed id 14656069)1, 2, 9 Soederberg L.... Naeslund J. (J. Neuropathol. Exp. Neurol. 2003)
    4. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PubMed id 20332099)1, 4 Kalsi G....Riley B.P. (Hum. Mol. Genet. 2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. CLAC binds to aggregated Abeta and Abeta fragments, and attenuates fibril elongation. (PubMed id 16300410)1, 2 Kakuyama H.... Tjernberg L.O. (Biochemistry 2005)
    7. Characterization of the Alzheimer's disease-associated CLAC protein and identification of an amyloid beta-peptide-binding site. (PubMed id 15522881)1, 2 Soederberg L.... Naeslund J. (J. Biol. Chem. 2005)
    8. CLAC binds to amyloid beta peptides through the positively charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils. (PubMed id 15615705)1, 2 Osada Y....Iwatsubo T. (J. Biol. Chem. 2005)
    9. Collagenous Alzheimer amyloid plaque component assembles amyloid fibrils into protease resistant aggregates. (PubMed id 15853808)1, 2 Soederberg L.... Tjernberg L.O. (FEBS J. 2005)
    10. Mostly separate distributions of CLAC- versus Abeta40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid deposits. (PubMed id 15215182)1, 2 Kowa H.... Iwatsubo T. (Am. J. Pathol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 84570 HGNC: 18603 AceView: COL25A1 Ensembl:ENSG00000188517 euGenes: HUgn84570
    ECgene: COL25A1 H-InvDB: COL25A1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for COL25A1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for COL25A1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for COL25A1 gene:
    Search GeneIP for patents involving COL25A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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