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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

COL22A1 Gene

protein-coding GIFtS: 49
GCID: GC08M139669

collagen, type XXII, alpha 1

Search for COL22A1
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Collagen, Type XXII, Alpha 1¹ ²
Collagen Alpha-1(XXII) Chain²

External Ids:	HGNC: 22989¹	Entrez Gene: 169044²	Ensembl: ENSG00000169436⁷	OMIM: 610026⁵	UniProtKB: Q8NFW1³

Export aliases for COL22A1 gene to outside databases

Previous GC identifers: GC08P138863 GC08M139711 GC08M139284 GC08M139571 GC08M134914

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for COL22A1:

COL22A1, a member of the FACIT (fibrillar-associated collagens with interrupted triple helices) subgroup of the

collagen protein family, specifically localizes to tissue junctions (Koch et al., 2004 (PubMed 15016833)).(supplied by

OMIM, Mar 2008)

UniProtKB/Swiss-Prot: COMA1_HUMAN, Q8NFW1

Function: Acts as a cell adhesion ligand for skin epithelial cells and fibroblasts

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_008046.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the COL22A1 gene promoter:
SRF GATA-3 Pbx1a SRF (504 AA) Lmo2 NF-kappaB GATA-2 NF-kappaB2 HSF2 NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: COL22A1 promoter sequence

Search SABiosciences Chromatin IP Primers for COL22A1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COL22A1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3 Ensembl cytogenetic band: 8q24.3 HGNC cytogenetic band: 8q24.3

COL22A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COL22A1 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M139669: view genomic region (about GC identifiers)

Start:	139,600,478 bp from pter	End:	139,926,249 bp from pter
Size:	325,772 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: COMA1_HUMAN, Q8NFW1 (See protein sequence)

Recommended Name: Collagen alpha-1(XXII) chain precursor

Size: 1626 amino acids; 161145 Da

Subcellular location: Secreted, extracellular space, extracellular matrix. Cytoplasm (By similarity)

Secondary accessions: B7ZMH0 C9K0G4 Q8IVT9

Alternative splicing: 3 isoforms: Q8NFW1-1 Q8NFW1-2 Q8NFW1-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for COL22A1: NX_Q8NFW1

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8NFW1

COL22A1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_690848.1

ENSEMBL proteins:

ENSP00000303153 ENSP00000428244 ENSP00000387655

Reactome Protein details: Q8NFW1
Human Recombinant Protein Products:

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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005581	collagen	IEA	--
GO:0005737	cytoplasm	--	--
GO:0005788	endoplasmic reticulum lumen	TAS	--

COL22A1 for ontologies About GeneDecksing

COL22A1 Antibody Products:

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Assay Products for COL22A1:

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

COL22A1 for domains About GeneDecksing

4 InterPro domains/families:

IPR001791 Laminin_G

IPR008160 Collagen

IPR008985 ConA-like_lec_gl_sf

IPR002035 VWF_A

Graphical View of Domain Structure for InterPro Entry Q8NFW1

ProtoNet protein and cluster: Q8NFW1

4 Blocks protein families:

IPB002035 Von Willebrand factor type A domain signature

IPB003129 Thrombospondin

IPB008160 Collagen triple helix repeat

IPB008161 Collagen helix repeat

UniProtKB/Swiss-Prot: COMA1_HUMAN, Q8NFW1

Similarity: Belongs to the fibril-associated collagens with interrupted helices (FACIT) family

Similarity: Contains 16 collagen-like domains

Similarity: Contains 1 laminin G-like domain

Similarity: Contains 1 VWFA domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: COMA1_HUMAN, Q8NFW1

Function: Acts as a cell adhesion ligand for skin epithelial cells and fibroblasts

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COL22A1
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate COL22A1 (see all 12):
		hsa-miR-29c* hsa-miR-29a hsa-miR-29c hsa-miR-1267 hsa-miR-3921 hsa-miR-583 hsa-miR-1297 hsa-miR-149

		SwitchGear 3'UTR luciferase reporter plasmid: COL22A1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COL22A1 OriGene shRNA RFP: COL22A1 OriGene siRNA: COL22A1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COL22A1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for COL22A1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COL22A1 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COL22A1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: COL22A1 (NM_152888)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for COL22A1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COL22A1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for COL22A1
		Search LifeMap BioReagents cell lines for COL22A1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COL22A1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Integrin Pathway

Integrin Pathway	1.00	UPA-UPAR Pathway	0.51
FAK1 Signaling	0.67	Transendothelial Migration of Leukocytes	0.38
GnRH Signaling	0.56	Inhibition of Angiogenesis by TSP1	0.37

Rho Family GTPases

Rho Family GTPases	1.00	MAPK Signaling	0.51
ERK Signaling	0.61	ILK Signaling	0.45
Molecular Mechanisms of Cancer	0.51

Collagen formation

	Collagen formation	1.00			Extracellular matrix organization	0.54
	Collagen biosynthesis and modifying enzymes	0.74			Secretion of collagens	0.49

Blood Coagulation Cascade

Blood Coagulation Cascade

1.00

Intrinsic Prothrombin Activation Pathway

0.96

PTEN Pathway

PTEN Pathway

1.00

Phospholipase-C Pathway

0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for COL22A1 (see all 15)

	MAPK Signaling
	Molecular Mechanisms of Cancer
	PTEN Pathway
	Transendothelial Migration of Leukocytes
	UPA-UPAR Pathway

4 Reactome Pathways for COL22A1

	Extracellular matrix organization
	Secretion of collagens
	Collagen biosynthesis and modifying enzymes
	Collagen formation

COL22A1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for COL22A1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/40 Interacting proteins for COL22A1 (ENSP00000303153⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 40)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
COL10A1	ENSP00000243222⁴	STRING: ENSP00000243222
COL11A1	ENSP00000351163⁴	STRING: ENSP00000351163
COL12A1	ENSP00000325146⁴	STRING: ENSP00000325146
COL13A1	ENSP00000348695⁴	STRING: ENSP00000348695
COL14A1	ENSP00000297848⁴	STRING: ENSP00000297848

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0030198	extracellular matrix organization	TAS	--

COL22A1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for COL22A1
Search CenterWatch for drugs/clinical trials and news about COL22A1 / COMA1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for COL22A1 gene:

NM_152888.1

Unigene Cluster for COL22A1:

Collagen, type XXII, alpha 1

Hs.117169 [show with all ESTs]

Unigene Representative Sequence: NM_152888

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000341807 ENST00000303045(uc011ljo.2 uc003yvd.3) ENST00000487854

ENST00000522546 ENST00000517515 ENST00000484387 ENST00000435777

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COL22A1
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate COL22A1 (see all 12):
		hsa-miR-29c* hsa-miR-29a hsa-miR-29c hsa-miR-1267 hsa-miR-3921 hsa-miR-583 hsa-miR-1297 hsa-miR-149

		SwitchGear 3'UTR luciferase reporter plasmid: COL22A1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COL22A1 OriGene shRNA RFP: COL22A1 OriGene siRNA: COL22A1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COL22A1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COL22A1 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COL22A1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: COL22A1 (NM_152888)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for COL22A1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COL22A1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COL22A1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat COL22A1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COL22A1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COL22A1

Additional cDNA sequence:

AF406780.1 BC042075.1 BC144535.1

6 DOTS entries:

DT.91869436 DT.97790858 DT.40125062 DT.92015975 DT.40302883 DT.403766

24/44 AceView cDNA sequences (see all 44):

AF406780 AA993145 NM_152888 AI090570 AI701471 BM553307 BC042075 AI992022

BE049553 AA988032 AA503523 AI865687 AA976185 BE349115 AA644121 BM674313

AA781676 BG370209 BX104734 BX094632 AI969133 BI829054 BF311370 BX097900

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for COL22A1 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^	23	^	24	^	25	^	26	^
SP1:																																																			-
SP2:

ExUns:	27	^	28	^	29	^	30	^	31	^	32	^	33	^	34	^	35	^	36	^	37	^	38	^	39	^	40	^	41	^	42	^	43	^	44	^	45	^	46	^	47	^	48	^	49	^	50	^	51	^	52	^
SP1:
SP2:	-																												-

ExUns:	53	^	54	^	55	^	56	^	57	^	58	^	59	^	60	^	61	^	62	^	63	^	64	^	65	^	66
SP1:
SP2:

ECgene alternative splicing isoforms for COL22A1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

COL22A1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCTGCCTGA

About this image

COL22A1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

6 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Brain

Brain

Diencephalic Ventricular Zone

Neural Tube

Diencephalon

Neural Tube

Telencephalon

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

N2/LSB/S/F8/CHIR-induced cells (Generation of midbra...)

See COL22A1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for COL22A1

SOURCE GeneReport for Unigene cluster: Hs.117169

UniProtKB/Swiss-Prot: COMA1_HUMAN, Q8NFW1

Tissue specificity: Restrictive expression is observed at tissue junctions such as the myotendinous junction in

skeletal and heart muscle, the articular cartilage-synovial fluid junction, or the border between the anagen hair

follicle and the dermis in the skin. It is deposited in the basement membrane zone of the myotendinous junction and

the hair follicle and associated with the extrafibrillar matrix in cartilage

SABiosciences Custom PCR Arrays for COL22A1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COL22A1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat COL22A1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COL22A1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COL22A1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COL22A1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for COL22A1 gene from 4/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	COL22A1¹	collagen, type XXII, alpha 1	69.45(n) 74.16(a)		420315 NM_001139439.1 NP_001132911.1
lizard (Anolis carolinensis)	Reptilia	COL22A1⁶	--	71(a)	1 ↔ 1	4(16758585-16908859)
zebrafish (Danio rerio)	Actinopterygii	prp¹	persistent plexus	60.1(n) 59.81(a)		100317029 XM_002665474.2 XP_002665520.2
worm (Caenorhabditis elegans)	Secernentea	dpy-5⁶ col-106⁶ (see all 11)	COLlagen family member (col-106) (see all 11)	31(a) 29(a) (see all 11)	possible ortholog possible ortholog (see all 11)	I(5432161-5433059) IV(1459862-1460787)

ENSEMBL Gene Tree for COL22A1 (if available)
TreeFam Gene Tree for COL22A1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for COL22A1 gene

COL4A6² COL19A1² COL11A2² COL4A5² COL24A1² COL4A4² COL5A3² COL1A1²

COL16A1² COL4A2² COL5A2² COL5A1² COL4A3² COL7A1² COL1A2² COL27A1²

COL2A1² COL3A1² COL4A1² COL11A1²

7 SIMAP similar genes for COL22A1 using alignment to 3 protein entries: COMA1_HUMAN (see all proteins):

COL21A1 DKFZp434L081 FCN2 ITGA2 SFTPD MARCO

COL9A2

COL22A1 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for COL22A1
PGOHUM00000244387

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs138578727^1,2		--	139600048(+)	`CTGTAA/GGTGGC`	1	--	ds500¹		0	--	--	--	--
rs78772773^1,2	C,	--	139600079(+)	`CAAATT/GAATGA`	1	--	ds500¹		2		CSA WA	120
rs141670567^1,2		--	139600109(+)	`GATCAG/TTCGGT`	1	--	ds500¹		0	--	--	--	--
rs188741335^1,2		--	139600158(+)	`GAGTAC/TTGGTG`	1	--	ds500¹		0	--	--	--	--
rs79084865^1,2	C,	--	139600346(+)	`CCCTCG/ATTCAT`	1	--	ds500¹		4		CSA WA NA EA	360
rs144428204^1,2		--	139600387(+)	`TGCTAC/TGGTTC`	1	--	ds500¹		0	--	--	--	--
rs181611067^1,2		--	139600447(+)	`GAAGTC/TGAATA`	1	--	ds500¹		0	--	--	--	--
rs75658226^1,2	C,F,	--	139600468(+)	`ATCATC/AAAGAG`	1	--	ds500¹		1		EA	120
rs73442787^1,2	C,F,	--	139600491(+)	`AGGAAA/CCTTGG`	1	--	ut3¹		3		WA CSA	122
rs75892225^1,2	C,	--	139600530(+)	`ATGTCG/ACATAC`	1	--	ut3¹		3		CSA NA EA	242

HapMap Linkage Disequilibrium report for COL22A1 (139600478 - 139850478 bp, first 250kb of COL22A1)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 10 variations for COL22A1
6 CNVs: 52407 52411 52409 52408 62861 52410
4 Indels: 62862 100522 70446 47477

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COL22A1

DNA2.0 Custom Variant and Variant Library Synthesis for COL22A1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

COL22A1 for disorders About MalaCards

COL22A1 for disorders About GeneDecksing

OMIM gene information: 610026 OMIM disorders: --

Human Genome Epidemiology (HuGE) Navigator: COL22A1 (3 documents)

Export disorders for COL22A1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for COL22A1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with COL22A1)

Utopia: connect your pdf to the dynamic
world of online information

A novel marker of tissue junctions, collagen XXII. (PubMed id 15016833)^{1, 2, 9} Koch M.... Bruckner-Tuderman L. (2004)
A meta-analysis of genome-wide data from five Europea n isolates reveals an association of COL22A1, SYT1, and GABRR2 with serum creat inine level. (PubMed id 20222955)^{1, 9} Pattaro C....Pramstaller P.P. (2010)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)² Nusbaum C....Lander E.S. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 169044	HGNC: 22989	AceView: COL22A1	Ensembl:ENSG00000169436	euGenes: HUgn169044
ECgene: COL22A1	H-InvDB: COL22A1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for COL22A1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for COL22A1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for COL22A1 gene:
Search GeneIP for patents involving COL22A1

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COL22A1 Gene

collagen, type XXII, alpha 1

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COL22A1 Gene

collagen, type XXII, alpha 1

Aliasesfor COL22A1 gene

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