Free for academic non-profit institutions. Other users need a Commercial license

Aliases for COL20A1 Gene

Aliases for COL20A1 Gene

  • Collagen, Type XX, Alpha 1 2 3
  • Collagen Alpha-1(XX) Chain 3
  • Collagen-Like Protein 3
  • BA261N11.4 3
  • KIAA1510 4

External Ids for COL20A1 Gene

Previous GeneCards Identifiers for COL20A1 Gene

  • GC20P061398
  • GC20P061924
  • GC20P058649

Summaries for COL20A1 Gene

GeneCards Summary for COL20A1 Gene

COL20A1 (Collagen, Type XX, Alpha 1) is a Protein Coding gene. Among its related pathways are ERK Signaling and ERK Signaling. An important paralog of this gene is MATN1.

UniProtKB/Swiss-Prot for COL20A1 Gene

  • Probable collagen protein

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COL20A1 Gene

Genomics for COL20A1 Gene

Regulatory Elements for COL20A1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for COL20A1 Gene

63,293,186 bp from pter
63,334,851 bp from pter
41,666 bases
Plus strand

Genomic View for COL20A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COL20A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COL20A1 Gene

Proteins for COL20A1 Gene

  • Protein details for COL20A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Collagen alpha-1(XX) chain
    Protein Accession:
    Secondary Accessions:
    • Q4VXQ4
    • Q6PI59
    • Q8WUT2
    • Q96CY9
    • Q9BQU6
    • Q9BQU7

    Protein attributes for COL20A1 Gene

    1284 amino acids
    Molecular mass:
    135830 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH19637.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for COL20A1 Gene

    Alternative splice isoforms for COL20A1 Gene


neXtProt entry for COL20A1 Gene

Proteomics data for COL20A1 Gene at MOPED

Post-translational modifications for COL20A1 Gene

  • Glycosylation at Asn607
  • Modification sites at PhosphoSitePlus

Other Protein References for COL20A1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for COL20A1 Gene

Domains for COL20A1 Gene

Gene Families for COL20A1 Gene

Suggested Antigen Peptide Sequences for COL20A1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 collagen-like domains.
  • Contains 2 collagen-like domains.
  • Contains 6 fibronectin type-III domains.
  • Contains 1 laminin G-like domain.
  • Contains 1 VWFA domain.
genes like me logo Genes that share domains with COL20A1: view

Function for COL20A1 Gene

Molecular function for COL20A1 Gene

UniProtKB/Swiss-Prot Function:
Probable collagen protein

Gene Ontology (GO) - Molecular Function for COL20A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with COL20A1: view

Phenotypes for COL20A1 Gene

GenomeRNAi human phenotypes for COL20A1:
genes like me logo Genes that share phenotypes with COL20A1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COL20A1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for COL20A1 Gene

Localization for COL20A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COL20A1 Gene

Secreted, extracellular space.

Subcellular locations from

Jensen Localization Image for COL20A1 Gene COMPARTMENTS Subcellular localization image for COL20A1 gene
Compartment Confidence
endoplasmic reticulum 4
extracellular 4
plasma membrane 1

Gene Ontology (GO) - Cellular Components for COL20A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005581 collagen trimer IEA --
GO:0005615 extracellular space IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0031012 colocalizes_with extracellular matrix TAS 22261194
genes like me logo Genes that share ontologies with COL20A1: view

Pathways for COL20A1 Gene

genes like me logo Genes that share pathways with COL20A1: view

Gene Ontology (GO) - Biological Process for COL20A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030198 extracellular matrix organization TAS --
genes like me logo Genes that share ontologies with COL20A1: view

Compounds for COL20A1 Gene

(4) Novoseek inferred chemical compound relationships for COL20A1 Gene

Compound -log(P) Hits PubMed IDs
hydroxylysine 79.3 2
hydroxyproline 46.7 2
gold 1.82 1
tyrosine 0 1
genes like me logo Genes that share compounds with COL20A1: view

Transcripts for COL20A1 Gene

Unigene Clusters for COL20A1 Gene

Collagen, type XX, alpha 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for COL20A1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for COL20A1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^
SP1: - -
SP4: -
SP6: -

ExUns: 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b ^ 28a · 28b
SP1: - -
SP2: - -
SP7: -

Relevant External Links for COL20A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for COL20A1 Gene

mRNA expression in normal human tissues for COL20A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for COL20A1 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (5.5), Brain - Amygdala (5.0), Brain - Cortex (4.9), Testis (4.8), and Brain - Substantia nigra (4.3).

Protein differential expression in normal tissues for COL20A1 Gene

This gene is overexpressed in Heart (40.6), Peripheral blood mononuclear cells (14.8), and Liver (13.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for COL20A1 Gene

SOURCE GeneReport for Unigene cluster for COL20A1 Gene Hs.271285

mRNA Expression by UniProt/SwissProt for COL20A1 Gene

Tissue specificity: High expression in heart, lung, liver, skeletal muscle, kidney, pancreas, spleen, testis, ovary, subthalamic nucleus and fetal liver. Weak expression in other tissues tested
genes like me logo Genes that share expressions with COL20A1: view

Expression partners for COL20A1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for COL20A1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for COL20A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia COL20A1 35
  • 83.33 (n)
  • 81.16 (a)
COL20A1 36
  • 73 (a)
(Canis familiaris)
Mammalia COL20A1 35
  • 81.34 (n)
  • 78.68 (a)
COL20A1 36
  • 77 (a)
(Mus musculus)
Mammalia Col20a1 35
  • 76.08 (n)
  • 72.39 (a)
Col20a1 16
Col20a1 36
  • 72 (a)
(Pan troglodytes)
Mammalia COL20A1 35
  • 98.68 (n)
  • 98.13 (a)
COL20A1 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Col20a1 35
  • 77.25 (n)
  • 74.54 (a)
(Monodelphis domestica)
Mammalia COL20A1 36
  • 58 (a)
(Ornithorhynchus anatinus)
Mammalia COL20A1 36
  • 58 (a)
(Gallus gallus)
Aves COL20A1 35
  • 61.76 (n)
  • 54.95 (a)
COL20A1 36
  • 47 (a)
(Anolis carolinensis)
Reptilia COL20A1 36
  • 37 (a)
(Danio rerio)
Actinopterygii slc35c2 36
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10963 36
  • 13 (a)
Species with no ortholog for COL20A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for COL20A1 Gene

Gene Tree for COL20A1 (if available)
Gene Tree for COL20A1 (if available)

Paralogs for COL20A1 Gene

Paralogs for COL20A1 Gene

(5) SIMAP similar genes for COL20A1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with COL20A1: view

Variants for COL20A1 Gene

Sequence variations from dbSNP and Humsavar for COL20A1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs753686 - 63,305,944(+) AGCCC(C/T)GGAGC reference, missense
rs755041 -- 63,314,407(+) GGGAC(A/G)AGGAC intron-variant
rs911043 -- 63,330,308(+) GCAGG(G/T)TGTGT intron-variant
rs911067 -- 63,314,557(+) GGGCT(C/T)CCCAT intron-variant
rs911068 -- 63,314,664(+) AGAGC(G/T)GCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COL20A1 Gene

Variant ID Type Subtype PubMed ID
nsv913073 CNV Loss 21882294
nsv9825 CNV Gain 18304495
dgv4618n71 CNV Loss 21882294
nsv913161 CNV Loss 21882294
nsv913165 CNV Loss 21882294
nsv913166 CNV Loss 21882294
dgv4626n71 CNV Loss 21882294
dgv4629n71 CNV Loss 21882294
nsv834032 CNV Loss 17160897
nsv470560 CNV Loss 18288195
nsv525279 CNV Loss 19592680
nsv913177 CNV Loss 21882294
dgv4630n71 CNV Loss 21882294
nsv913181 CNV Loss 21882294
dgv4631n71 CNV Loss 21882294
nsv913183 CNV Loss 21882294
dgv4632n71 CNV Loss 21882294
esv1600196 CNV Deletion 17803354
esv2722904 CNV Deletion 23290073

Relevant External Links for COL20A1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COL20A1 Gene

Disorders for COL20A1 Gene

No disorders were found for COL20A1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for COL20A1 Gene

Publications for COL20A1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  5. Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury. (PMID: 22261194) Barallobre-Barreiro J. … Mayr M. (Circulation 2012) 3

Products for COL20A1 Gene

Sources for COL20A1 Gene

Back to Top