Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

COL1A2 Gene

protein-coding GIFtS: 71
GCID: GC07P094023

collagen, type I, alpha 2

(Previous name: osteogenesis imperfecta type IV )
(Previous symbol: OI4)

Explore 65 diseases affiliated with
COL1A2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Collagen, Type I, Alpha 2¹ ²		Collagen Alpha-2(I) Chain²
OI4¹ ²		Collagen I, Alpha-2 Polypeptide²
Alpha-2 Type I Collagen² ³		Collagen Of Skin, Tendon And Bone, Alpha-2 Chain²
Osteogenesis Imperfecta Type IV¹		Type I Procollagen²
Alpha 2(I)-Collagen²

External Ids:	HGNC: 2198¹	Entrez Gene: 1278²	Ensembl: ENSG00000164692⁷	OMIM: 120160⁵	UniProtKB: P08123³

Export aliases for COL1A2 gene to outside databases

Previous GC identifers: GC07P092559 GC07P093622 GC07P093636 GC07P093668 GC07P093861 GC07P088631

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for COL1A2:

This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2

chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis

and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type

VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms

associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1

chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three

transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.

(provided by R. Dalgleish, Feb 2008)

UniProtKB/Swiss-Prot: CO1A2_HUMAN, P08123

Function: Type I collagen is a member of group I collagen (fibrillar forming collagen)

Gene Wiki entry for COL1A2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the COL1A2 gene promoter:
c-Fos C/EBPbeta Sp1 AP-1 ATF-2 c-Jun CBF(2)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 8): COL1A2 promoter sequence

Search SABiosciences Chromatin IP Primers for COL1A2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COL1A2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1 Ensembl cytogenetic band: 7q21.3 HGNC cytogenetic band: 7q21.3

COL1A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COL1A2 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P094023: view genomic region (about GC identifiers)

Start:	94,023,873 bp from pter	End:	94,060,544 bp from pter
Size:	36,672 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 93,353,052-93,389,700

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CO1A2_HUMAN, P08123 (See protein sequence)

Recommended Name: Collagen alpha-2(I) chain precursor

Size: 1366 amino acids; 129314 Da

Subunit: Trimers of one alpha 2(I) and two alpha 1(I) chains

Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)

Secondary accessions: P02464 Q13897 Q13997 Q13998 Q14038 Q14057 Q15177 Q15947 Q16480 Q16511 Q7Z5S6

Q9UEB6 Q9UEF9 Q9UM83 Q9UMI1 Q9UML5 Q9UMM6 Q9UPH0

Explore the universe of human proteins at neXtProt for COL1A2: NX_P08123

Post-translational modifications:

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P08123

COL1A2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000080.2

ENSEMBL proteins:

ENSP00000297268

Reactome Protein details: P08123
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for COL1A2
	GenScript Custom Purified and Recombinant Proteins Services for COL1A2
	Novus Biologicals COL1A2 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005581	collagen	--	--
GO:0005584	collagen type I	TAS	6267597
GO:0005615	extracellular space	IDA	18375391
GO:0005788	endoplasmic reticulum lumen	TAS	--

COL1A2 for ontologies About GeneDecksing

COL1A2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies: COL1A2 OriGene Custom Antibody Services for COL1A2
	GenScript Custom Superior Antibodies Services for COL1A2
	Novus Biologicals COL1A2 Antibodies
	Abcam antibodies for COL1A2
	Browse Antibodies at Uscn
	ThermoFisher Antibodies for COL1A2

Assay Products for COL1A2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for COL1A2
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

COL1A2 for domains About GeneDecksing

2 InterPro domains/families:

IPR000885 Fib_collagen_C

IPR008160 Collagen

Graphical View of Domain Structure for InterPro Entry P08123

ProtoNet protein and cluster: P08123

3 Blocks protein families:

IPB000885 Fibrillar collagen

IPB008160 Collagen triple helix repeat

IPB008161 Collagen helix repeat

UniProtKB/Swiss-Prot: CO1A2_HUMAN, P08123

Domain: The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by

controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen

fibrils. It binds a calcium ion which is essential for its function (By similarity)

Similarity: Belongs to the fibrillar collagen family

Similarity: Contains 1 fibrillar collagen NC1 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CO1A2_HUMAN, P08123

Function: Type I collagen is a member of group I collagen (fibrillar forming collagen)

Genatlas biochemistry entry for COL1A2:

collagen type I,alpha 2,fibril forming,putative down-regulated c-Myc target gene,

miRNA Products:		miRTarBase miRNAs that target COL1A2: hsa-mir-29c (MIRT001928), hsa-let-7g (MIRT000472)

		OriGene 3'-UTR Clone: COL1A2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COL1A2
		8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate COL1A2 (see all 35):
		hsa-miR-642a hsa-miR-300 hsa-let-7d hsa-miR-29a hsa-miR-25 hsa-miR-342-3p hsa-let-7g hsa-let-7a

		SwitchGear 3'UTR luciferase reporter plasmid: COL1A2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COL1A2 (see all 7) OriGene shRNA RFP: COL1A2 OriGene siRNA: COL1A2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COL1A2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for COL1A2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COL1A2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COL1A2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: COL1A2 (NM_000089)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for COL1A2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COL1A2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for COL1A2
		LifeMap BioReagents: cell lines associated with COL1A2: PureStem 7SMOO32, NCr-fac & Meso Progenitor, PureStem E15, Meso-prx/latp Progenitor, PureStem MEL2, NCr-fac Progenitor, PureStem SK11, NCr-fac & Meso-prx Progenitor

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COL1A2

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005201	extracellular matrix structural constituent	NAS	8982144
GO:0005515	protein binding	IPI	18375391
GO:0030674	protein binding, bridging	IMP	18375391
GO:0042802	identical protein binding	IDA	17211858
GO:0046332	SMAD binding	IEA	--

COL1A2 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for COL1A2:

Increased gamma-H2AX phosphory

Animal Models:
Mouse knock-out Col1a2^tm1Mcbr for COL1A2
10 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Col1a2):

behavior/neurological	cardiovascular system	cellular	growth/size	integument
limbs/digits/tail	mortality/aging	muscle	normal	skeleton

COL1A2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/32 super-pathways (see all 32) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell adhesion_Integrin-mediated cell adhesion and migration

Cell adhesion_Integrin-mediated cell adhesion and migration	1.00	Cytoskeleton remodeling Integrin outside-in signaling	0.37
Cell adhesion Integrin-mediated cell adhesion and migration	1.00	Cell adhesion_Endothelial cell contacts by non-junctional mechanisms	0.21
Cytoskeleton remodeling_Integrin outside-in signaling	0.37	Cell adhesion Endothelial cell contacts by non-junctional mechanisms	0.21

Integrin Pathway

Integrin Pathway	1.00	UPA-UPAR Pathway	0.51
FAK1 Signaling	0.67	Transendothelial Migration of Leukocytes	0.38
GnRH Signaling	0.56	Inhibition of Angiogenesis by TSP1	0.37

Collagen formation

Collagen formation	1.00	Extracellular matrix organization	0.54
Collagen biosynthesis and modifying enzymes	0.74	Secretion of collagens	0.49
Assembly of collagen fibrils and other multimeric structures	0.65

Rho Family GTPases

Rho Family GTPases	1.00	MAPK Signaling	0.51
ERK Signaling	0.61	ILK Signaling	0.45
Molecular Mechanisms of Cancer	0.51

Formation of collagen fibres

	Formation of collagen fibrils	1.00			Type XII and XIV collagens associate with type I and type II fibrils.	0.45
	Formation of collagen fibres	1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5/8 EMD Millipore Pathways for COL1A2 (see all 8)

	Cell adhesion Integrin-mediated cell adhesion and migration
	Development Hedgehog and PTH signaling pathways in bone and cartilage development
	Cytoskeleton remodeling Integrin outside-in signaling
	Cell adhesion Integrin inside-out signaling
	Cell adhesion ECM remodeling

5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for COL1A2 (see all 15)

	MAPK Signaling
	Molecular Mechanisms of Cancer
	PTEN Pathway
	Transendothelial Migration of Leukocytes
	UPA-UPAR Pathway

5/7 GeneGo (Thomson Reuters) Pathways for COL1A2 (see all 7)

	Development Hedgehog and PTH signaling pathways in bone and cartilage development
	Cell adhesion Endothelial cell contacts by non-junctional mechanisms
	Cytoskeleton remodeling Integrin outside-in signaling
	Development Endothelin-1/EDNRA transactivation of EGFR
	Cell adhesion Integrin-mediated cell adhesion and migration

5/9 BioSystems Pathways for COL1A2 (see all 9)

	Focal Adhesion
	IL4-mediated signaling events
	Validated transcriptional targets of AP1 family members Fra1 and Fra2
	VEGFR3 signaling in lymphatic endothelium
	C-MYB transcription factor network

5/22 Reactome Pathways for COL1A2 (see all 22)

	Formation of collagen fibrils
	Assembly of collagen fibrils and other multimeric structures
	Type XII and XIV collagens associate with type I and type II fibrils.
	GPVI stimulates PI3K beta, gamma
	Gelatin degradation by MMP19

1 PharmGKB Pathway for COL1A2

Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

4 Kegg Pathways (Kegg details for COL1A2):

	Focal adhesion
	ECM-receptor interaction
	Protein digestion and absorption
	Amoebiasis

COL1A2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for COL1A2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/108 Interacting proteins for COL1A2 (P08123^{2, 3} ENSP00000297268⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 108)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ITGA2	P17301²^,³, ENSP00000296585⁴	MINT-4792053 I2D: score=2 STRING: ENSP00000296585
APP	P05067³, ENSP00000284981⁴	I2D: score=2 STRING: ENSP00000284981
FN1	P02751³, ENSP00000346839⁴	I2D: score=2 STRING: ENSP00000346839
MMP9	P14780³, ENSP00000361405⁴	I2D: score=2 STRING: ENSP00000361405
SPARC	P09486³, ENSP00000231061⁴	I2D: score=2 STRING: ENSP00000231061

About this table

Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001501	skeletal system development	IMP	18375391
GO:0001568	blood vessel development	IMP	17211858
GO:0007179	transforming growth factor beta receptor signaling pathway	IDA	17217948
GO:0007266	Rho protein signal transduction	IDA	17217948
GO:0007411	axon guidance	TAS	--

COL1A2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

COL1A2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for COL1A2

1 HMDB Compound for COL1A2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

1 DrugBank Compound for COL1A2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Collagenase	--	9001-12-1	target	--	12101112

10/25 Novoseek chemical compound relationships for COL1A2 gene (see all 25) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
mspi	68.1	17	15777651 (3), 15599596 (2), 7835877 (2), 1675622 (1) (see all 10)
procollagen	65.3	3	7916744 (1), 18266309 (1), 10073586 (1)
rsai	62.8	7	7835877 (2), 16114820 (1), 18284430 (1), 11208313 (1) (see all 5)
nppa	58.7	2	14993121 (1), 15582321 (1)
ecori	39.4	7	7835877 (2), 1675622 (1), 16114820 (1), 11208313 (1) (see all 5)
cyanogen bromide	38.4	1	9721184 (1)
mithramycin	36.3	1	11114293 (1)
nppb	25.8	2	14993121 (1), 15582321 (1)
cysteine	23.9	8	1990009 (2), 16786509 (1), 2066103 (1), 11359465 (1) (see all 7)
ly294002	21.7	6	14610066 (2), 15153536 (2), 19726546 (1)

Search CenterWatch for drugs/clinical trials and news about COL1A2 / CO1A2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for COL1A2 gene:

NM_000089.3

Unigene Cluster for COL1A2:

Collagen, type I, alpha 2

Hs.489142 [show with all ESTs]

Unigene Representative Sequence: J03464

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000297268(uc003ung.1 uc011kib.1 uc022ahm.1 uc010lfh.1 uc010lfi.1)

ENST00000488298 ENST00000473573 ENST00000497316 ENST00000461525 ENST00000467931

ENST00000481570 ENST00000469732 ENST00000478215 ENST00000488121 ENST00000492110

ENST00000464916

miRNA Products:		OriGene 3'-UTR Clone: COL1A2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat COL1A2
		8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate COL1A2 (see all 35):
		hsa-miR-642a hsa-miR-300 hsa-let-7d hsa-miR-29a hsa-miR-25 hsa-miR-342-3p hsa-let-7g hsa-let-7a

		SwitchGear 3'UTR luciferase reporter plasmid: COL1A2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COL1A2 (see all 7) OriGene shRNA RFP: COL1A2 OriGene siRNA: COL1A2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COL1A2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COL1A2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COL1A2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: COL1A2 (NM_000089)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for COL1A2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COL1A2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COL1A2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat COL1A2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COL1A2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COL1A2

Additional cDNA sequence:

AK223175.1 AK226074.1 AK297786.1 AK300194.1 AK309504.1 BC042586.1 BC054498.1 J00114.1

J03464.1 L47668.1 S96821.1 V00503.1 X55525.1 Y00724.1 Z74616.1

24/73 DOTS entries (see all 73):

DT.95171357 DT.100884035 DT.100884020 DT.95171333 DT.100884018 DT.95171203 DT.100884016 DT.97866912

DT.100884013 DT.100884027 DT.100032421 DT.100045973 DT.95171339 DT.121064706 DT.100662598 DT.121064715

DT.75178264 DT.121064825 DT.121064821 DT.95171156 DT.121064776 DT.121064787 DT.453710 DT.121642682

24/892 AceView cDNA sequences (see all 892):

AI383642 CD515508 BQ004440 CB215847 BM679967 BM679202 R71565 AA375995

AI755044 CN484471 BM722065 CB045026 AA343289 AI752770 BX508373 BQ183632

AA375677 CN484779 CB269181 BG057935 CA427114 BU580539 AI198930 BM722524

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for COL1A2 (see all 13) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^	23	^	24	^	25	^	26	^
SP1:
SP2:																	-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-
SP3:
SP4:
SP5:																													-		-		-		-		-		-		-		-		-		-		-		-

ExUns:	27	^	28	^	29a	·	29b	^	30	^	31a	·	31b	^	32	^	33	^	34a	·	34b	^	35	^	36a	·	36b	^	37a	·	37b	^	38a	·	38b	^	39	^	40a	·	40b	^	41a	·	41b	·	41c	^	42	^	43a	·
SP1:					-						-										-						-		-				-						-
SP2:	-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-
SP3:					-						-										-
SP4:											-
SP5:	-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-

ExUns:	43b	^	44a	·	44b	^	45a	·	45b	·	45c	^	46a	·	46b	·	46c	·	46d	^	47a	·	47b	^	48a	·	48b	·	48c	^	49	^	50
SP1:	-		-								-		-
SP2:	-		-		-		-				-		-
SP3:
SP4:
SP5:	-		-		-		-		-		-		-		-

ECgene alternative splicing isoforms for COL1A2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

COL1A2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATGAGGAGA

About this image

COL1A2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/32 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 32)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Caudal Endochondral Bones

Endochondral Osteoblasts

Selective marker (cell-identifying gene)

Bone

Caudal Endochondral Bones

Endochondral Preosteoblasts

Bone

Endochondral Facial Bones

Endochondral Osteoblasts

Bone

Endochondral Facial Bones

Endochondral Preosteoblasts

Bone

Facial Sutures

Facial Fusing Suture Cells

Bone

Membranous Facial Bones

Intramembranous Osteoblasts

Bone

Membranous Facial Bones

Intramembranous Preosteoblasts

Bone

Rostral Endochondral Facial Bones

Endochondral Osteoblasts

Bone

Rostral Endochondral Facial Bones

Endochondral Preosteoblasts

Bone

Rostral Skull Membranous Bones

Intramembranous Osteoblasts

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 10/18 LifeMap Cells (see all 18)

Name

Category

mK3 (Cell line)

Kidney

mK4 (Cell line)

Kidney

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)

Lateral Plate Mesoderm, Neural Crest

PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

Pelleted mesenchymal stem cells (Chondrogenic differe...)

Single-cell constructs (Generation of fibroc...)

Cartilage

TGF?3- and IGF1-induced embryoid bodies (Generation of fibroc...)

Cartilage

Embryoid body constructs (Generation of fibroc...)

Cartilage

See COL1A2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for COL1A2

SOURCE GeneReport for Unigene cluster: Hs.489142

UniProtKB/Swiss-Prot: CO1A2_HUMAN, P08123

Tissue specificity: Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium

hydroxyapatite

SABiosciences Expression via Pathway-Focused PCR Arrays including COL1A2 (see all 6):

Osteogenesis in human mouse rat

Fibrosis in human mouse rat

Cell Surface Markers in human mouse rat

TGFB/BMP Signaling Pathway in human mouse rat

Wound Healing in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COL1A2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat COL1A2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COL1A2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COL1A2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COL1A2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for COL1A2 gene from 5/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	COL1A2¹	collagen, type I, alpha 2	80.28(n) 83.81(a)		396243 NM_001079714.2 NP_001073182.2
lizard (Anolis carolinensis)	Reptilia	COL1A2⁶	--	81(a)	1 ↔ 1	6(22172811-22229242)
African clawed frog (Xenopus laevis)	Amphibia	col1a2-prov²	procollagen, type I, alpha 2	79.06(n)		BC049287.1
zebrafish (Danio rerio)	Actinopterygii	col1a2²	collagen, type I, alpha 2	77.2(n)		336471 AJ318213.1
honey bee (Apis mellifera)	Insecta	--	--	43(a)	1 → many	GroupUn.493(29585-38789)

ENSEMBL Gene Tree for COL1A2 (if available)
TreeFam Gene Tree for COL1A2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for COL1A2 gene

COL4A6² COL19A1² COL11A2² COL4A5² COL24A1² COL4A4² COL5A3² COL1A1²

COL16A1² COL4A2² COL5A2² COL5A1² COL4A3² COL22A1² COL7A1² COL27A1²

COL3A1² COL2A1² COL4A1² COL11A1²

11 SIMAP similar genes for COL1A2 using alignment to 7 protein entries: CO1A2_HUMAN (see all proteins):

COL2A1 COL1A1 COL5A2 FCN2 COL3A1 C1QTNF9

MARCO COL11A1 COL5A3 COL28A1 COL5A1

COL1A2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs193922172^1,2	C,	non-pathogenic	93364918(+)	`TTTTT-/TCTTTC`	1	--	int¹		0	--	--	--	--
rs66820119^1,2	C	pathogenic	93360063(+)	`CTCTAA/C/GAACTT`	1	--	spa¹		0	--	--	--	--
rs72656387^1,2	C	pathogenic	93367870(+)	`CCGCCA/GGTCCC`	2	S G	mis¹		0	--	--	--	--
rs72656402^1,2	C	pathogenic	93368932(+)	`CTGCTG/TGGCCC`	2	G W	mis¹		0	--	--	--	--
rs121912907^1,2	C	pathogenic	93373766(+)	`TGCTGG/TTCCAA`	2	G V	mis¹		0	--	--	--	--
rs72658152^1,2	C	pathogenic	93377011(+)	`AACCTA/GGTCTC`	2	S G	mis¹		0	--	--	--	--
rs72658200^1,2	C	pathogenic	93382808(+)	`CTCCTA/GGCACT`	2	S G	mis¹		0	--	--	--	--
rs72659343^1,2	C	pathogenic	93386828(+)	`CTGGCG/TAAACC`	2	E *	stg¹		0	--	--	--	--
rs147058179^1,2	C	probable-non-pathogenic	93368234(+)	`CTTCCC/TGGCGT`	2	P	syn¹		1		NA	4552
rs34511999^1,2	C,F,	probable-non-pathogenic	93368237(-)	`GCAACG/ACCGGG`	2	/G	syn¹		3		NA EU	5757

HapMap Linkage Disequilibrium report for COL1A2 (94023873 - 94060544 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for COL1A2: --
Human Gene Mutation Database (HGMD): COL1A2

Locus Specific Mutation Databases (LSDB): COL1A2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COL1A2

DNA2.0 Custom Variant and Variant Library Synthesis for COL1A2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

COL1A2 for disorders           About GeneDecksing

OMIM gene information: 120160
OMIM disorders: 130060  166220  259420  166210  166710  225320
UniProtKB/Swiss-Prot: CO1A2_HUMAN, P08123

Defects in COL1A2 are the cause of Ehlers-Danlos syndrome type 7B (EDS7B) [MIM:130060]. EDS is a connective

tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint

hyperlaxity. EDS7B is marked by bilateral congenital hip dislocation, hyperlaxity of the joints, and recurrent partial

dislocations

Defects in COL1A2 are a cause of osteogenesis imperfecta type 1 (OI1) [MIM:166200]. A dominantly inherited

connective tissue disorder characterized by bone fragility and blue sclerae. Osteogenesis imperfecta type 1 is

non-deforming with normal height or mild short stature, and no dentinogenesis imperfecta

Defects in COL1A2 are a cause of osteogenesis imperfecta type 2 (OI2) [MIM:166210]; also known as osteogenesis

imperfecta congenita (OIC) or lethal perinatal. A connective tissue disorder characterized by bone fragility, with

many perinatal fractures, severe bowing of long bones, undermineralization, and death in the perinatal period due to

respiratory insufficiency

Defects in COL1A2 are the cause of Ehlers-Danlos syndrome autosomal recessive cardiac valvular form (EDSCV)

[MIM:225320]. A connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to

tissue fragility and joint hyperlaxity. In addition to joint laxity, skin hyperextensibility and friability, and

abnormal scar formation, patients have mitral valve prolapse and insufficiency, mitral regurgitation, and aortic

insufficiency

Defects in COL1A2 are a cause of osteogenesis imperfecta type 3 (OI3) [MIM:259420]. A connective tissue

disorder characterized by progressively deforming bones, very short stature, a triangular face, severe scoliosis,

grayish sclera, and dentinogenesis imperfecta

Defects in COL1A2 are a cause of osteogenesis imperfecta type 4 (OI4) [MIM:166220]; also known as osteogenesis

imperfecta with normal sclerae. A connective tissue disorder characterized by moderately short stature, mild to

moderate scoliosis, grayish or white sclera and dentinogenesis imperfecta

Note=A chromosomal aberration involving COL1A2 may be a cause of lipoblastomas, which are benign tumors

resulting from transformation of adipocytes, usually diagnosed in children. Translocation t(7;8)(p22;q13) with PLAG1

20/65 diseases for COL1A2 (see all 65): About MalaCards

osteogenesis imperfecta ehlers-danlos syndrome ehlers-danlos syndrome type viib osteogenesis imperfecta type i

ehlers-danlos syndrome, cardiac valvular form marfan syndrome osteogenesis imperfecta, type ii ehlers-danlos syndrome type viia

osteogenesis imperfecta type iii osteoporosis osteogenesis imperfecta type 4 silver-russell syndrome

mitral valve prolapse osteoporosis, postmenopausal connective tissue disease dental fluorosis

dentinogenesis imperfecta short stature intracranial aneurysm abdominal aortic aneurysm

6 diseases from the University of Copenhagen DISEASES database for COL1A2:

Osteogenesis imperfecta Ehlers-Danlos syndrome Dentinogenesis imperfecta Osteoporosis

Systemic scleroderma Idiopathic juvenile osteoporosis

10/28 Novoseek disease relationships for COL1A2 gene (see all 28) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
osteogenesis imperfecta	94.5	68	1967900 (2), 1990009 (2), 15241796 (2), 10982177 (2) (see all 57)
oi, type i	90.5	6	1967900 (1), 8456806 (1), 8096115 (1), 9443882 (1) (see all 6)
oi, type iv	90	8	1967900 (1), 11836364 (1), 8096115 (1), 18375391 (1) (see all 8)
osteogenesis imperfecta, type ii	88.7	5	17431984 (2), 18996919 (1), 17508636 (1)
oi, type iii	88.5	6	8100856 (2), 19208385 (1), 9240878 (1), 11359465 (1)
ehlers-danlos syndrome, type i	78	1	1684560 (1)
ehlers-danlos syndrome	77.2	15	1990839 (2), 15077201 (2), 10982177 (2), 8071956 (2) (see all 11)
osteopenia	53.6	1	2052622 (1)
sclerosis systemic	53.3	1	10872800 (1)
otosclerosis	52.7	3	17568407 (1), 16168495 (1), 15211650 (1)

GeneTests: COL1A2

Genetic Association Database (GAD): COL1A2
Human Genome Epidemiology (HuGE) Navigator: COL1A2 (39 documents)

Export disorders for COL1A2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for COL1A2 gene, integrated from 9 sources (see all 470):
(articles sorted by number of sources associating them with COL1A2)

Utopia: connect your pdf to the dynamic
world of online information

Interaction of collagen-related genes and susceptibility to betel quid-induced oral submucous fibrosis. (PubMed id 12101112)^{1, 4, 7} Chiu C.J....Chen C.J. (2002)
Arginine for glycine substitution in the triple-helical domain of the products of one alpha 2(I) collagen allele (COL1A2) produces the osteogenesis imperfecta type IV phenotype. (PubMed id 2897363)^{1, 2, 3} Wenstrup R.J.... Byers P.H. (1988)
Mutational spectrum of type I collagen genes in Korean patients with osteogenesis imperfecta. (PubMed id 16705691)^{1, 2, 9} Lee K.S....Koo S.K. (2006)
Collagen type I alpha2 (COL1A2) is the susceptible gene for intracranial aneurysms. (PubMed id 14739420)^{1, 4, 9} Yoneyama T....Inoue I. (2004)
Lack of correlation between the type of COL1A1 or COL1A2 mutation and hearing loss in osteogenesis imperfecta patients. (PubMed id 15241796)^{1, 4, 9} Hartikka H....Ala-Kokko L. (2004)
Mutation and polymorphism spectrum in osteogenesis imperfecta type II: implications for genotype-phenotype relationships. (PubMed id 18996919)^{1, 2, 9} Bodian D.L....Klein T.E. (2009)
Proposed association between the COL1A1 and COL1A2 genes and otosclerosis is not supported by a case-control study in Spain. (PubMed id 15211650)^{1, 4, 9} Rodriguez L....Zapata C. (2004)
Rare autosomal recessive cardiac valvular form of Ehlers-Danlos syndrome results from mutations in the COL1A2 gene that activate the nonsense-mediated RNA decay pathway. (PubMed id 15077201)^{1, 2, 9} Schwarze U.... Byers P.H. (2004)
Tests of linkage and association of the COL1A2 gene with bone phenotypes' variation in Chinese nuclear families. (PubMed id 14555266)^{1, 4, 9} Deng F.Y....Deng H.W. (2003)
Relation of PvuII site polymorphism in the COL1A2 gene to the risk of fractures in prepubertal Finnish girls. (PubMed id 12813128)^{1, 4, 9} Suuriniemi M....Cheng S. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1278	HGNC: 2198	AceView: COL1A2	Ensembl:ENSG00000164692	euGenes: HUgn1278
ECgene: COL1A2	Kegg: 1278	H-InvDB: COL1A2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for COL1A2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for COL1A2	Genetics and Cytogenetics in Oncology and Haematology
Osteogenesis imperfecta variant database	http://oi.gene.le.ac.uk/home.php?select_db=COL1A2
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/COL1A2

Intellectual Property for COL1A2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for COL1A2 gene:
Search GeneIP for patents involving COL1A2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for COL1A2		OriGene shRNA RFP for COL1A2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for COL1A2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for COL1A2
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for COL1A2		OriGene 3'-UTR Clone for COL1A2
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for COL1A2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for COL1A2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for COL1A2		OriGene Custom Protein Services for COL1A2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat COL1A2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing COL1A2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat COL1A2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat COL1A2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat COL1A2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat COL1A2

	GenScript Custom Purified and Recombinant Proteins Services for COL1A2		GenScript cDNA clones with any tag delivered in your preferred vector for COL1A2
	GenScript Custom Assay Services for COL1A2		GenScript Custom Superior Antibodies Services for COL1A2
	GenScript Custom overexpressing Cell Line Services for COL1A2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in COL1A2 promoter
	Search Chromatin IP Primers for COL1A2
	RT² qPCR Primer Assay in human, mouse, rat COL1A2
	GNC Network for COL1A2
	SABiosciences PCR Arrays including human, mouse, rat COL1A2

Search Tocris compounds for COL1A2

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	COL1A2 antibodies
	COL1A2 proteins

	Antibodies for COL1A2
	See all of Abcam's Antibodies, Kits and Proteins for COL1A2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn

Cell Lines associated with COL1A2: PureStem 7SMOO32, NCr-fac & Meso Progenitor,
PureStem E15, Meso-prx/latp Progenitor, PureStem MEL2, NCr-fac Progenitor, PureStem SK11, NCr-fac & Meso-prx Progenitor

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COL1A2

	SwitchGear 3'UTR luciferase reporter plasmids for COL1A2
	SwitchGear Promoter luciferase reporter plasmids for COL1A2

ThermoFisher Antibodies for COL1A2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COL1A2

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes COL1A2 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

COL1A2 Gene

collagen, type I, alpha 2

Aliases
for COL1A2 gene

Summaries
for COL1A2 gene

Genomic Views
for COL1A2 gene

Proteins
for COL1A2 gene

Protein Domains /
Families
for COL1A2 gene

Function
for COL1A2 gene

Pathways & Interactions
for COL1A2 gene

Drugs & Compounds
for COL1A2 gene

Transcripts
for COL1A2 gene

Expression
for COL1A2 gene

Orthologs
for COL1A2 gene

Paralogs
for COL1A2 gene

Genomic Variants
for COL1A2 gene

Disorders / Diseases
for COL1A2 gene

Publications
for COL1A2 gene

External Searches for COL1A2 gene

Genome Databases showing COL1A2 gene

Other Databases showing COL1A2 gene

Specialized Databases showing COL1A2 gene

Intellectual Property
for COL1A2 gene

Products
for COL1A2 gene

View Random Gene

Gastric Cancer
Pulmonary Fibrosis
Scoliosis idiopathic
Liver Fibrosis
Otosclerosis
glomerulosclerosis
OI, TYPE III
Cystic Fibrosis
SHORT STATURE
Osteoarthritis
OSTEOGENESIS IMPERFECTA, TYPE II
Intracranial Aneurysm
Osteogenesis Imperfecta
OI, TYPE I
Osteopenia
Osteoporosis
EHLERS-DANLOS SYNDROME, TYPE I
Tumors
Metastasis
Necrosis
genetic disorder
OI, TYPE IV
Hip Dislocation Congenital
Sclerosis Systemic
COL1A1/2-Related Osteogenesis Imperfecta
Cancer
Ehlers-Danlos Syndrome
Connective Tissue Diseases
Marfan Syndrome

Advanced Search

Export list of displayed genes

COL1A2 Gene

collagen, type I, alpha 2

Aliasesfor COL1A2 gene

Summariesfor COL1A2 gene

Genomic Viewsfor COL1A2 gene

Proteinsfor COL1A2 gene

Protein Domains /Familiesfor COL1A2 gene

Functionfor COL1A2 gene

Pathways & Interactionsfor COL1A2 gene

Drugs & Compoundsfor COL1A2 gene

Transcriptsfor COL1A2 gene

Expression for COL1A2 gene

Orthologsfor COL1A2 gene

Paralogsfor COL1A2 gene

Genomic Variantsfor COL1A2 gene

Disorders / Diseasesfor COL1A2 gene

Publicationsfor COL1A2 gene

External Searches for COL1A2 gene

Genome Databases showing COL1A2 gene

Other Databases showing COL1A2 gene

Specialized Databases showing COL1A2 gene

Intellectual Propertyfor COL1A2 gene

Productsfor COL1A2 gene

View Random Gene

Aliases
for COL1A2 gene

Summaries
for COL1A2 gene

Genomic Views
for COL1A2 gene

Proteins
for COL1A2 gene

Protein Domains /
Families
for COL1A2 gene

Function
for COL1A2 gene

Pathways & Interactions
for COL1A2 gene

Drugs & Compounds
for COL1A2 gene

Transcripts
for COL1A2 gene

Expression
for COL1A2 gene

Orthologs
for COL1A2 gene

Paralogs
for COL1A2 gene

Genomic Variants
for COL1A2 gene

Disorders / Diseases
for COL1A2 gene

Publications
for COL1A2 gene

Intellectual Property
for COL1A2 gene

Products
for COL1A2 gene