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COL1A1 Gene

protein-coding   GIFtS: 73
GCID: GC17M048260

Collagen, Type I, Alpha 1

  See COL1A1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Collagen, Type I, Alpha 11 2     Collagen Alpha-1(I) Chain2
Alpha-1 Type I Collagen2 3     Collagen Alpha-1(I) Chain Preproprotein2
OI42     Collagen Of Skin, Tendon And Bone, Alpha-1 Chain2
Collagen Alpha 1 Chain Type I2     Pro-Alpha-1 Collagen Type 12

External Ids:    HGNC: 21971   Entrez Gene: 12772   Ensembl: ENSG000001088217   OMIM: 1201505   UniProtKB: P024523   

Export aliases for COL1A1 gene to outside databases

Previous GC identifers: GC17M047864 GC17M050742 GC17M048602 GC17M048736 GC17M045617 GC17M043632


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for COL1A1 Gene:
This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one
alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone,
cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV,
Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic
osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for
platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called
dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts,
resulting from the use of alternate polyadenylation signals, have been identified for this gene. (provided by R.
Dalgleish, Feb 2008)

GeneCards Summary for COL1A1 Gene:
COL1A1 (collagen, type I, alpha 1) is a protein-coding gene. Diseases associated with COL1A1 include osteogenesis imperfecta type i, and ehlers-danlos syndrome, classic type, col1a1-related. GO annotations related to this gene include platelet-derived growth factor binding and identical protein binding. An important paralog of this gene is COL4A6.

UniProtKB/Swiss-Prot: CO1A1_HUMAN, P02452
Function: Type I collagen is a member of group I collagen (fibrillar forming collagen)

Gene Wiki entry for COL1A1 (Collagen, type I, alpha 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the COL1A1 gene promoter:
         GR   USF1   GR-beta   HSF1 (long)   GATA-1   AREB6   USF-1   c-Myb   HSF1short   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCOL1A1 promoter sequence
   Search Chromatin IP Primers for COL1A1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat COL1A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.33   Ensembl cytogenetic band:  17q21.33   HGNC cytogenetic band: 17q21.33

COL1A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
COL1A1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M048260:  view genomic region     (about GC identifiers)

Start:
48,260,650 bp from pter      End:
48,279,000 bp from pter
Size:
18,351 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CO1A1_HUMAN, P02452 (See protein sequence)
Recommended Name: Collagen alpha-1(I) chain precursor  
Size: 1464 amino acids; 138941 Da
Subunit: Trimers of one alpha 2(I) and two alpha 1(I) chains. Interacts with MRC2 (By similarity). Interacts with
TRAM2
Sequence caution: Sequence=BAD92834.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
4 PDB 3D structures from and Proteopedia for COL1A1:
1Q7D (3D)        2LLP (3D)        3EJH (3D)        3GXE (3D)    
Secondary accessions: O76045 P78441 Q13896 Q13902 Q13903 Q14037 Q14992 Q15176 Q15201 Q16050
Q59F64 Q7KZ30 Q7KZ34 Q8IVI5 Q8N473 Q9UML6 Q9UMM7

Explore the universe of human proteins at neXtProt for COL1A1: NX_P02452

Explore proteomics data for COL1A1 at MOPED

Post-translational modifications: 

  • Proline residues at the third position of the tripeptide repeating unit (G-X-P) are hydroxylated in some or all of
    the chains. Proline residues at the second position of the tripeptide repeating unit (G-P-X) are hydroxylated in
    some of the chains1
  • O-linked glycan consists of a Glc-Gal disaccharide bound to the oxygen atom of a post-translationally added
    hydroxyl group1
  • Glycosylation2 at Lys265, Thr478, Lys1108, Thr1234, Asn1365
  • Modification sites at PhosphoSitePlus

  • See COL1A1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000079.2  
    ENSEMBL proteins: 
     ENSP00000225964   ENSP00000460459  
    Reactome Protein details: P02452

    COL1A1 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant COL1A1 Protein
    R&D Systems Recombinant & Natural Proteins for COL1A1 (Collagen I alpha 1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for COL1A1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for COL1A1
    GenScript Custom Purified and Recombinant Proteins Services for COL1A1
    Novus Biologicals COL1A1 Proteins
    Novus Biologicals COL1A1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for COL1A1 

     
    antibodies-online proteins for COL1A1 (8 products) 

     
    antibodies-online peptides for COL1A1

    COL1A1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of COL1A1
    R&D Systems Antibodies for COL1A1 (Collagen I alpha 1)
    OriGene Antibodies for COL1A1
    OriGene Custom Antibody Services for COL1A1
    Novus Biologicals COL1A1 Antibodies
    Abcam antibodies for COL1A1 (P08123, P02452, P20908, P02461)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for COL1A1
    antibodies-online antibodies for COL1A1 (34 products) 

    COL1A1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for COL1A1
    R&D Systems ELISAs for COL1A1 (Collagen I alpha 1)
    GenScript Custom Assay Services for COL1A1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for COL1A1 
    antibodies-online kits for COL1A1 (21 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    COLLAGEN: Collagens

    3 InterPro protein domains:
     IPR000885 Fib_collagen_C
     IPR001007 VWF_C
     IPR008160 Collagen

    Graphical View of Domain Structure for InterPro Entry P02452

    ProtoNet protein and cluster: P02452

    4 Blocks protein domains:
    IPB000885 Fibrillar collagen
    IPB001007 von Willebrand factor
    IPB008160 Collagen triple helix repeat
    IPB008161 Collagen helix repeat


    UniProtKB/Swiss-Prot: CO1A1_HUMAN, P02452
    Domain: The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by
    controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen
    fibrils. It binds a calcium ion which is essential for its function (By similarity)
    Similarity: Belongs to the fibrillar collagen family
    Similarity: Contains 1 fibrillar collagen NC1 domain
    Similarity: Contains 1 VWFC domain


    Find genes that share domains with COL1A1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CO1A1_HUMAN, P02452
    Function: Type I collagen is a member of group I collagen (fibrillar forming collagen)

         Genatlas biochemistry entry for COL1A1:
    collagen type I,alpha 1,fibril forming,putative downregulated c-Myc target gene,

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005201extracellular matrix structural constituent IEA--
    GO:0005515protein binding IPI14749390
    GO:0042802identical protein binding IDA17211858
    GO:0046872metal ion binding IEA--
    GO:0048407platelet-derived growth factor binding IDA8900172
         
    Find genes that share ontologies with COL1A1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for COL1A1:
     Decreased G3BP1 protein expres  Synthetic lethal with Ras 

         Selected MGI mutant phenotypes (inferred from 60 alleles(MGI details for Col1a1) (see all 27):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear 
     hematopoietic system  homeostasis/metabolism  immune system  integument  limbs/digits/tail 

    Find genes that share phenotypes with COL1A1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for COL1A1: Col1a1tm2.1Bst Col1a1tm1Bst Col1a1tm1Dab Col1a1tm2Bst

       genOway: Develop your customized and physiologically relevant rodent model for COL1A1

    miRNA
    Products:
        
    miRTarBase miRNAs that target COL1A1:
    hsa-mir-124-3p (MIRT022587), hsa-mir-29c-3p (MIRT000928), hsa-mir-29b-3p (MIRT000100), hsa-mir-143-3p (MIRT004242), hsa-mir-133a-3p (MIRT021714)

    Block miRNA regulation of human, mouse, rat COL1A1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate COL1A1 (see all 54):
    hsa-let-7d hsa-miR-1224-3p hsa-miR-1260b hsa-miR-29a hsa-miR-371-5p hsa-miR-218 hsa-let-7g hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidCOL1A1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for COL1A1
    Predesigned siRNA for gene silencing in human, mouse, rat COL1A1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for COL1A1

    Clone
    Products:
         
    OriGene clones in human, mouse for COL1A1 (see all 6)
    OriGene ORF clones in mouse, rat for COL1A1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: COL1A1 (NM_000088)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COL1A1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COL1A1
    Addgene plasmids for COL1A1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for COL1A1
    ESI BIO PureStem Progenitors for COL1A1: 
    PureStem 7PEND24, NCr-fac & Meso-prx Progenitor, PureStem 7SMOO32, NCr-fac & Meso Progenitor,
    PureStem E15, Meso-prx/latp Progenitor, PureStem MEL2, NCr-fac Progenitor,
    PureStem SK11, NCr-fac & Meso-prx Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COL1A1

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-10070) for COL1A1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CO1A1_HUMAN, P02452: Secreted, extracellular space, extracellular matrix (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum4
    extracellular4
    nucleus2
    cytoskeleton1
    lysosome1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix ----
    GO:0005581collagen ----
    GO:0005584collagen type I IMP14976317
    GO:0005615extracellular space IDA--

    Find genes that share ontologies with COL1A1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for COL1A1 About   (see all 23)  
    See pathways by source

    SuperPathContained pathways About
    1Collagen biosynthesis and modifying enzymes
    Collagen biosynthesis and modifying enzymes0.75
    Intrinsic Prothrombin Activation Pathway0.39
    Collagen formation0.75
    Blood Coagulation Cascade0.38
    Assembly of collagen fibrils and other multimeric structures0.62
    2Focal adhesion
    Focal adhesion0.65
    ECM-receptor interaction0.31
    Focal Adhesion0.65
    3Cell adhesion ECM remodeling
    Metalloproteases in connective tissue degradation0.31
    Cell adhesion ECM remodeling0.31
    4Integrin Pathway
    FAK1 Signaling0.67
    UPA-UPAR Pathway0.56
    Integrin Pathway0.67
    Inhibition of Angiogenesis by TSP10.50
    GnRH Signaling0.56
    Transendothelial Migration of Leukocytes0.38
    5ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58


    Find genes that share SuperPaths with COL1A1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for COL1A1 (see all 15)
        MAPK Signaling
    Molecular Mechanisms of Cancer
    PTEN Pathway
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway

    Selected GeneGo (Thomson Reuters) Pathways for COL1A1 (see all 8)
        Development Hedgehog and PTH signaling pathways in bone and cartilage development
    Development Endothelin-1/EDNRA transactivation of EGFR
    Cell adhesion Integrin inside-out signaling
    Transcription Role of VDR in regulation of genes involved in osteoporosis
    Cell adhesion Endothelial cell contacts by non-junctional mechanisms

    Selected BioSystems Pathways for COL1A1 (see all 6)
        Focal Adhesion
    Senescence and Autophagy
    IL4-mediated signaling events
    VEGFR3 signaling in lymphatic endothelium
    Inflammatory Response Pathway

    Selected Reactome Pathways for COL1A1 (see all 14)
        Platelet Adhesion to exposed collagen
    Integrin cell surface interactions
    Assembly of collagen fibrils and other multimeric structures
    Collagen degradation
    GPVI-mediated activation cascade

    1 PharmGKB Pathway for COL1A1
        Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

    5 Kegg Pathways  (Kegg details for COL1A1):
        PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Protein digestion and absorption
    Amoebiasis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including COL1A1 (see all 12): 
              Osteogenesis in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Cell Surface Markers in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for COL1A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for COL1A1 (P024521, 2, 3 ENSP000002259644) via UniProtKB, MINT, STRING, and/or I2D (see all 114)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COCHO434052, 3, ENSP000002163614MINT-6796048 I2D: score=1 STRING: ENSP00000216361
    CAPN1P073843, ENSP000002792474I2D: score=3 STRING: ENSP00000279247
    SPARCP094863, ENSP000002310614I2D: score=3 STRING: ENSP00000231061
    TXNP105993, ENSP000003636414I2D: score=3 STRING: ENSP00000363641
    VWFP042753, ENSP000002614054I2D: score=3 STRING: ENSP00000261405
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 46):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development IMP14976317
    GO:0001503ossification ----
    GO:0001568blood vessel development IMP17211858
    GO:0001649osteoblast differentiation IEA--
    GO:0001957intramembranous ossification IEA--

    Find genes that share ontologies with COL1A1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for COL1A1 (CO1A1)

    1 HMDB Compound for COL1A1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for COL1A1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Collagenase-- 9001-12-1target--12855673 17440987 12535212 15659034 12101112

    Selected Novoseek inferred chemical compound relationships for COL1A1 gene (see all 34)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    procollagen 67.1 3 8418862 (1), 15727634 (1), 9076960 (1)
    vitamin d 58.9 37 16159929 (2), 17028393 (1), 12916320 (1), 12879219 (1) (see all 28)
    nppa 54.6 3 15582321 (2), 14993121 (1)
    rsai 50.7 7 10928224 (1), 12879219 (1), 1982109 (1), 12491092 (1) (see all 5)
    hydroxylysine 49.9 1 10329027 (1)
    imatinib 44.1 1 17195235 (1)
    apai 39.2 3 16261459 (1), 20015871 (1)
    mspi 36.6 4 10928224 (1), 1982109 (1), 11208313 (1)
    xbai 27.2 3 12879219 (1), 20015871 (1), 11420783 (1)
    bleomycin 24.7 3 16187293 (2), 17387717 (1)



    Find genes that share compounds with COL1A1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for COL1A1 gene: 
    NM_000088.3  

    Unigene Cluster for COL1A1:

    Collagen, type I, alpha 1
    Hs.172928  [show with all ESTs]
    Unigene Representative Sequence: Z74615
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000225964(uc002iqm.3) ENST00000510710 ENST00000486572 ENST00000511732
    ENST00000494334 ENST00000476387 ENST00000504289 ENST00000463440 ENST00000471344
    ENST00000485870 ENST00000495677 ENST00000474644 ENST00000507689
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate COL1A1 (see all 54):
    hsa-let-7d hsa-miR-1224-3p hsa-miR-1260b hsa-miR-29a hsa-miR-371-5p hsa-miR-218 hsa-let-7g hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidCOL1A1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for COL1A1
    Predesigned siRNA for gene silencing in human, mouse, rat COL1A1
    Clone
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    OriGene clones in human, mouse for COL1A1 (see all 6)
    OriGene ORF clones in mouse, rat for COL1A1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: COL1A1 (NM_000088)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for COL1A1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat COL1A1
    Addgene plasmids for COL1A1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for COL1A1
    OriGene qSTAR qPCR primer pairs in human, mouse for COL1A1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat COL1A1
      QuantiTect SYBR Green Assays in human, mouse, rat COL1A1
      QuantiFast Probe-based Assays in human, mouse, rat COL1A1
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-10070) for COL1A1 

    Additional mRNA sequence: 

    AB209597.1 AK297731.1 BC036531.2 JQ236861.1 K01228.1 M36546.1 S64596.1 X06269.1 
    X07884.1 Z74615.1 

    Selected DOTS entries (see all 92):

    DT.102841307  DT.95105014  DT.87077250  DT.95077068  DT.100662609  DT.100662592  DT.92404389  DT.95171216 
    DT.95123444  DT.91808350  DT.95353801  DT.100788832  DT.95301324  DT.92476449  DT.102841298  DT.100775390 
    DT.95171185  DT.100748130  DT.100799297  DT.120952848  DT.120952850  DT.100647432  DT.120952797  DT.120953013 

    Selected AceView cDNA sequences (see all 2025):

    AW067809 BF448544 N24817 BU845101 CA439533 BM987377 BQ941669 BM698037 
    BU617491 BU528413 AI753941 BM722696 BQ932370 BF914815 AI754861 AW068985 
    AI925025 BU850092 CA427579 AW068075 BU553655 BX424890 AI753357 BG938486 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for COL1A1 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^
    SP1:                                                                                                                                                            
    SP2:                                                              -                                                                                             
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -   

    ExUns: 19a · 19b ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39a · 39b ^ 40 ^ 41 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:  -                                                                                                                                                         

    ExUns: 42 ^ 43 ^ 44 ^ 45a · 45b ^ 46a · 46b ^ 47 ^ 48a · 48b ^ 49a · 49b
    SP1:                                                                        
    SP2:                                                                        
    SP3:                                                                        
    SP4:                                                                        
    SP5:                                                                        


    ECgene alternative splicing isoforms for COL1A1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    COL1A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCAAAAACC
    COL1A1 Expression
    About this image


    COL1A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 37) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 31 entries
             Endochondral Preosteoblasts Caudal Endochondral Bones
             Stylopod Long Bone
             Notch-transfected mesenchymal stromal cells (SB623)
             Pelleted mesenchymal stem cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 18 entries
             Intervertebral Disc Annulus Fibrosus Cells Annulus Fibrosus
             Matrix-induced autologous cultured chondrocytes (MACI«)
             BMP2 induced Embryoid Bodies
     
     Limb (Muscoskeletal System)    fully expand to see all 8 entries
             Prechondrocytic Mesenchymal Cells Stylopod
             Stylopod
     
     Tendon & Ligament (Muscoskeletal System)    fully expand to see all 5 entries
             Early Tenocyte Cells Axial Tendon Primordia
             Tenocytes
     
     Dermis (Integumentary System)    fully expand to see all 4 entries
             Dermal Fibroblasts Dorsal Dermis
    COL1A1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    COL1A1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.172928

    UniProtKB/Swiss-Prot: CO1A1_HUMAN, P02452
    Tissue specificity: Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with
    calcium hydroxyapatite

        Pathway & Disease-focused RT2 Profiler PCR Arrays including COL1A1 (see all 12): 
              Osteogenesis in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Cell Surface Markers in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for COL1A1
    OriGene qSTAR qPCR primer pairs in human, mouse for COL1A1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat COL1A1
    QuantiTect SYBR Green Assays in human, mouse, rat COL1A1
    QuantiFast Probe-based Assays in human, mouse, rat COL1A1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for COL1A1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for COL1A1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Col1a11 , 5 collagen, type I, alpha 11, 5 89.58(n)1
    92.43(a)1
      11 (59.01 cM)5
    128421  NM_007742.31  NP_031768.21 
     949362245 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    19(a)
    many ↔ many
    1(1177700-1258653)
    lizard
    (Anolis carolinensis)
    Reptilia COL1A16
    collagen, type I, alpha 1
    86(a)
    1 ↔ 1
    6(77523349-77568650)
    African clawed frog
    (Xenopus laevis)
    Amphibia col1a1-prov2 collagen, type I, alpha 1 79.21(n)    BC049829.1 
    zebrafish
    (Danio rerio)
    Actinopterygii col1a12 collagen, type I, alpha 1 79.27(n)   337158  BC063249.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cg25C6
    Collagen type IV
    28(a)
    1 → many
    2L(5029609-5037279)


    ENSEMBL Gene Tree for COL1A1 (if available)
    TreeFam Gene Tree for COL1A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for COL1A1 gene
    COL4A62  COL11A22  COL4A52  COL24A12  COL4A42  COL5A32  COL4A22  COL5A22  
    COL5A12  COL4A32  COL1A22  COL7A12  COL2A12  COL3A12  COL27A12  COL4A12  
    COL11A12  
    Selected SIMAP similar genes for COL1A1 using alignment to 12 protein entries:     CO1A1_HUMAN (see all proteins) (see all similar genes):
    COL2A1    COL1A2    DKFZp434L081    ECM2    COL6A2    COL5A2
    COL3A1    MSR1    COL7A1    EMID1    C1QB    COL5A1
    COL6A1    COL11A2    COL11A1    SFTPD    COL14A1    FCN2

    Find genes that share paralogs with COL1A1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for COL1A1 (see all 1397)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs573778121,2,,4
    COsteogenesis imperfecta 2 (OI2)4 untested149286182(+) GGGTCC/G/TGGGTT 3 R G mis10--------
    VAR_0016814
    Osteogenesis imperfecta 2 (OI2)4--see VAR_0016812 G R mis40--------
    VAR_0016484
    Osteogenesis imperfecta 1 (OI1)4--see VAR_0016482 G C mis40--------
    VAR_0017004
    Osteogenesis imperfecta 2 (OI2)4--see VAR_0017002 G V mis40--------
    VAR_0633374
    Osteogenesis imperfecta 2 (OI2)4--see VAR_0633372 G S mis40--------
    VAR_0017204
    Osteogenesis imperfecta 2 (OI2)4--see VAR_0017202 G C mis40--------
    VAR_0017334
    Osteogenesis imperfecta 2 (OI2)4--see VAR_0017332 W C mis40--------
    VAR_0017274
    Osteogenesis imperfecta 2 (OI2)4--see VAR_0017272 G S mis40--------
    VAR_0017034
    Osteogenesis imperfecta 2 (OI2)4--see VAR_0017032 G V mis40--------
    VAR_0016684
    Osteogenesis imperfecta 4 (OI4)4--see VAR_0016682 G S mis40--------

    HapMap Linkage Disequilibrium report for COL1A1 (48260650 - 48279000 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for COL1A1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2670012CNV Deletion23128226
    nsv908597CNV Loss21882294
    nsv908588CNV Loss21882294
    dgv3225n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): COL1A1
    Locus Specific Mutation Databases (LSDB): COL1A1

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing COL1A1
    DNA2.0 Custom Variant and Variant Library Synthesis for COL1A1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 120150   
    OMIM disorders: 166200  166210  259420  166220  130000  130060  166710  114000  
    UniProtKB/Swiss-Prot: CO1A1_HUMAN, P02452
  • Caffey disease (CAFFD) [MIM:114000]: Characterized by an infantile episode of massive subperiosteal new
    bone formation that typically involves the diaphyses of the long bones, mandible, and clavicles. The involved
    bones may also appear inflamed, with painful swelling and systemic fever often accompanying the illness. The bone
    changes usually begin before 5 months of age and resolve before 2 years of age. Note=The disease is caused by
    mutations affecting the gene represented in this entry
  • Ehlers-Danlos syndrome 1 (EDS1) [MIM:130000]: A connective tissue disorder characterized by
    hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS1 is the severe
    form of classic Ehlers-Danlos syndrome. Note=The disease is caused by mutations affecting the gene represented in
    this entry
  • Ehlers-Danlos syndrome 7A (EDS7A) [MIM:130060]: A connective tissue disorder characterized by
    hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. Marked by bilateral
    congenital hip dislocation, hyperlaxity of the joints, and recurrent partial dislocations. Note=The disease is
    caused by mutations affecting the gene represented in this entry
  • Osteogenesis imperfecta 1 (OI1) [MIM:166200]: An autosomal dominant form of osteogenesis imperfecta, a
    connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after
    minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and
    perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis
    imperfecta, hearing loss, and blue sclerae. OI1 is a non-deforming form with normal height or mild short stature,
    and no dentinogenesis imperfecta. Note=The disease is caused by mutations affecting the gene represented in this
    entry
  • Osteogenesis imperfecta 2 (OI2) [MIM:166210]: An autosomal dominant form of osteogenesis imperfecta, a
    connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after
    minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and
    perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis
    imperfecta, hearing loss, and blue sclerae. OI2 is characterized by bone fragility, with many perinatal
    fractures, severe bowing of long bones, undermineralization, and death in the perinatal period due to respiratory
    insufficiency. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Osteogenesis imperfecta 3 (OI3) [MIM:259420]: An autosomal dominant form of osteogenesis imperfecta, a
    connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after
    minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and
    perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis
    imperfecta, hearing loss, and blue sclerae. OI3 is characterized by progressively deforming bones, very short
    stature, a triangular face, severe scoliosis, grayish sclera and dentinogenesis imperfecta. Note=The disease is
    caused by mutations affecting the gene represented in this entry
  • Osteogenesis imperfecta 4 (OI4) [MIM:166220]: An autosomal dominant form of osteogenesis imperfecta, a
    connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after
    minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and
    perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis
    imperfecta, hearing loss, and blue sclerae. OI4 is characterized by moderately short stature, mild to moderate
    scoliosis, grayish or white sclera and dentinogenesis imperfecta. Note=The disease is caused by mutations
    affecting the gene represented in this entry
  • Osteoporosis (OSTEOP) [MIM:166710]: A systemic skeletal disorder characterized by decreased bone mass and
    deterioration of bone microarchitecture without alteration in the composition of bone. The result is fragile
    bones and an increased risk of fractures, even after minimal trauma. Osteoporosis is a chronic condition of
    multifactorial etiology and is usually clinically silent until a fracture occurs. Note=Disease susceptibility is
    associated with variations affecting the gene represented in this entry
  • Note=A chromosomal aberration involving COL1A1 is found in dermatofibrosarcoma protuberans. Translocation
    t(17;22)(q22;q13) with PDGF

  • Selected diseases for COL1A1 (see all 36):    
    About MalaCards
    osteogenesis imperfecta type i    ehlers-danlos syndrome, classic type, col1a1-related    ehlers-danlos syndrome, vascular-like type    type i ehlers-danlos syndrome
    ehlers?Óˇdanlos syndrome classical type    oi type ii    caffey disease    ehlers-danlos syndrome, type vii
    osteoporosis    dermatofibrosarcoma    dermatofibrosarcoma protuberans    osteogenesis imperfecta type 4
    high bone mass osteogenesis imperfecta    col1a1/2-related osteogenesis imperfecta    frozen shoulder    osteogenesis imperfecta type iii
    perinatally lethal osteogenesis imperfecta    osteogenesis imperfecta    ehlers-danlos/osteogenesis imperfecta syndrome    ehlers?Óˇdanlos syndrome arthrochalasia type

    8 diseases from the University of Copenhagen DISEASES database for COL1A1:
    Osteogenesis imperfecta     Dermatofibrosarcoma     Caffey disease     Osteoporosis
    Dentinogenesis imperfecta     Ehlers-Danlos syndrome     Otosclerosis     Systemic scleroderma

    Find genes that share disorders with COL1A1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for COL1A1 gene (see all 36)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    osteogenesis imperfecta 94.7 89 1967900 (2), 9752968 (2), 15241796 (2), 2220807 (2) (see all 76)
    oi, type i 93.9 55 8544188 (4), 10521849 (4), 11860074 (4), 18755172 (3) (see all 26)
    osteogenesis imperfecta, type ii 91.2 8 18996919 (1), 1460046 (1), 7487936 (1), 17508636 (1) (see all 7)
    oi, type iv 88.3 2 11208313 (1), 11286811 (1)
    oi, type iii 87.4 8 8100856 (2), 9240878 (1), 19283684 (1), 7789952 (1) (see all 6)
    dermatofibrosarcoma protuberans 85.5 18 12786837 (2), 16040406 (2), 20133221 (1), 16681596 (1) (see all 12)
    dentinogenesis imperfecta 80.3 1 11286811 (1)
    ehlers-danlos syndrome, type i 75.1 2 1684560 (1), 17118335 (1)
    caffey disease 73.9 4 18704262 (1), 15864348 (1)
    ehlers-danlos syndrome 72.2 8 1990839 (1), 1867198 (1), 16816023 (1), 18272325 (1) (see all 8)

    GeneTests: COL1A1
    GeneReviews: COL1A1
    Genetic Association Database (GAD): COL1A1
    Human Genome Epidemiology (HuGE) Navigator: COL1A1 (153 documents)

    Export disorders for COL1A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for COL1A1 gene, integrated from 10 sources (see all 855) (see top 10):
    (articles sorted by number of sources associating them with COL1A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Reduced bone density and osteoporosis associated with a polymorphic Sp1 binding site in the collagen type I alpha 1 gene. (PubMed id 8841196)1, 2, 4, 9 Grant S.F.A.... Ralston S.H. (Nat. Genet. 1996)
    2. Interaction of collagen-related genes and susceptibility to betel quid-induced oral submucous fibrosis. (PubMed id 12101112)1, 4, 7 Chiu C.J....Chen C.J. (amp 2002)
    3. Structure of a full-length cDNA clone for the prepro alpha 1(I) chain of human type I procollagen. (PubMed id 3178743)1, 2, 3 Tromp G.... Prockup D.J. (Biochem. J. 1988)
    4. Fine structural analysis of the human pro-alpha 1 (I) collagen gene. Promoter structure, AluI repeats, and polymorphic transcripts. (PubMed id 2857713)1, 2, 3 Chu M.-L.... Ramirez F. (J. Biol. Chem. 1985)
    5. Association between bone mineral density and polymorphisms of the VDR, ERalpha, COL1A1 and CTR genes in Spanish postmenopausal women. (PubMed id 15966503)1, 4, 9 BandrAcs E....GarcA-a-Foncillas J. (J. Endocrinol. Invest. 2005)
    6. Lack of correlation between the type of COL1A1 or COL1A2 mutation and hearing loss in osteogenesis imperfecta patients. (PubMed id 15241796)1, 4, 9 Hartikka H....Ala-Kokko L. (Hum. Mutat. 2004)
    7. Genetic control of bone density and turnover: role of the collagen 1alpha1, estrogen receptor, and vitamin D receptor genes. (PubMed id 11316004)1, 4, 9 Brown M.A....Eisman J.A. (J. Bone Miner. Res. 2001)
    8. [Association study between mutations of transcription regulator sequences of COL1A1 gene and idiopathic con-genital talipes equinovarus]. (PubMed id 18550494)1, 4, 9 Zhao N....Sun K.L. (Yi Chuan 2008)
    9. Association of a COL1A1 polymorphism with lumbar disc disease in young military recruits. (PubMed id 15994869)1, 4, 9 Tilkeridis C....Stratakis C.A. (J. Med. Genet. 2005)
    10. Proposed association between the COL1A1 and COL1A2 genes and otosclerosis is not supported by a case-control study in Spain. (PubMed id 15211650)1, 4, 9 RodrA-guez L....Zapata C. (Am. J. Med. Genet. A 2004)
    11. Study of the association between polymorphisms of the COL1A1 gene and HBV-related liver cirrhosis in Chinese patients. (PubMed id 18536987)1, 4, 9 Zhao Y.P....Gao C.F. (Dig. Dis. Sci. 2009)
    12. Absence of association between COL1A1 polymorphisms and high myopia in the Japanese population. (PubMed id 18836165)1, 4, 9 Nakanishi H....Yoshimura N. (amp 2009)
    13. Mutation and polymorphism spectrum in osteogenesis imperfecta type II: implications for genotype-phenotype relationships. (PubMed id 18996919)1, 2, 9 Bodian D.L.... Klein T.E. (Hum. Mol. Genet. 2009)
    14. COL1A1, ESR1, VDR and TGFB1 polymorphisms and haplotypes in relation to BMD in Spanish postmenopausal women. (PubMed id 17021946)1, 4, 9 Bustamante M....Grinberg D. (Osteoporos Int 2007)
    15. The COL1A1 gene and high myopia susceptibility in Japanese. (PubMed id 17557158)1, 4, 9 Inamori Y....Mizuki N. (Hum. Genet. 2007)
    16. Epistatic interactions between genomic regions containing the COL1A1 gene and genes regulating osteoclast differentiation may influence femoral neck bone mineral density. (PubMed id 17331078)1, 4, 9 Yang T.L....Deng H.W. (Ann. Hum. Genet. 2007)
    17. Mutations in type I collagen genes in Japanese osteogenesis imperfecta patients. (PubMed id 17875077)1, 2, 9 Kataoka K....Tanaka H. (Pediatr. Int. 2007)
    18. Systematic assessment of the tagging polymorphisms of the COL1A1 gene for high myopia. (PubMed id 17273809)1, 4, 9 Liang C.L....Juo S.H. (J. Hum. Genet. 2007)
    19. Mutational spectrum of type I collagen genes in Korean patients with osteogenesis imperfecta. (PubMed id 16705691)1, 2, 9 Lee K.S.... Koo S.K. (Hum. Mutat. 2006)
    20. [Association analysis on the polymorphisms of PCOL2 and Sp1 binding sites of COL1A1 gene and the congenital dislocation of the hip in Chinese population]. (PubMed id 15952128)1, 4, 9 Jiang J....Ji S.J. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2005)
    21. Analysis of the COL1A1 and COL1A2 genes by PCR amplification and scanning by conformation-sensitive gel electrophoresis identifies only COL1A1 mutations in 15 patients with osteogenesis imperfecta type I: identification of common sequences of null-allele mutations. (PubMed id 9443882)1, 2, 9 Korkko J.M....Prockop D.J. (Am. J. Hum. Genet. 1998)
    22. A rare haplotype in the upstream regulatory region of COL1A1 is associated with reduced bone quality and hip fracture. (PubMed id 19016596)1, 4, 9 Jin H....Ralston S. (J. Bone Miner. Res. 2009)
    23. COL1A1 and COL2A1 genes and myopia susceptibility: evidence of association and suggestive linkage to the COL2A1 locus. (PubMed id 19387081)1, 4, 9 Metlapally R....Young T.L. (amp 2009)
    24. Do HOXB9 and COL1A1 genes play a role in congenital dislocation of the hip? Study in a Caucasian population. (PubMed id 19341834)1, 4, 9 Rouault K....FAcrec C. (Osteoarthr. Cartil. 2009)
    25. Promoter and intron 1 polymorphisms of COL1A1 interact to regulate transcription and susceptibility to osteoporosis. (PubMed id 19429913)1, 4, 9 Jin H....Ralston S.H. (Hum. Mol. Genet. 2009)
    26. Association and linkage analysis of COL1A1 and AHSG gene polymorphisms with femoral neck bone geometric parameters in both Caucasian and Chinese nuclear families. (PubMed id 17303000)1, 4, 9 Jiang H....Deng H.W. (Acta Pharmacol. Sin. 2007)
    27. [Relations between VDR3 and COL1A1 genes and markers of bone tissue metabolism in patients with chronic obstructive pulmonary disease]. (PubMed id 17019952)1, 4, 9 Gel'tser B.I....Bubnov O.I.u. (Ter. Arkh. 2006)
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    164. Chemical cleavage method for the detection of RNA base changes: experience in the application to collagen mutations in osteogenesis imperfecta. (PubMed id 8456808)1, 2 Bateman J.F....Cole W.G. (Am. J. Med. Genet. 1993)
    165. SSCP detection of a Gly565Val substitution in the pro alpha 1(I) collagen chain resulting in osteogenesis imperfecta type II. (PubMed id 8100209)1, 2 Mackay K.... Dalgleish R. (Hum. Genet. 1993)
    166. Serine for glycine substitutions in type I collagen in two cases of type IV osteogenesis imperfecta (OI). Additional evidence for a regional model of OI pathophysiology. (PubMed id 8094076)1, 2 Marini J.C.... Orrison B.M. (J. Biol. Chem. 1993)
    167. BiP binds type I procollagen pro alpha chains with mutations in the carboxyl-terminal propeptide synthesized by cells from patients with osteogenesis imperfecta. (PubMed id 8349698)1, 2 Chessler S.D. and Byers P.H. (J. Biol. Chem. 1993)
    168. A cysteine for glycine substitution at position 175 in an alpha 1 (I) chain of type I collagen produces a clinically heterogeneous form of osteogenesis imperfecta. (PubMed id 8339541)1, 2 Wirtz M.K.... Hollister D.W. (Connect. Tissue Res. 1993)
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    170. An osteopenic nonfracture syndrome with features of mild osteogenesis imperfecta associated with the substitution of a cysteine for glycine at triple helix position 43 in the pro alpha 1(I) chain of type I collagen. (PubMed id 1737847)1, 2 Shapiro J.R.... Rowe D.W. (J. Clin. Invest. 1992)
    171. A tripeptide deletion in the triple-helical domain of the pro alpha 1(I) chain of type I procollagen in a patient with lethal osteogenesis imperfecta does not alter cleavage of the molecule by N-proteinase. (PubMed id 1460047)1, 2 Wallis G.A.... Byers P.H. (J. Biol. Chem. 1992)
    172. The clinicopathological features of three babies with osteogenesis imperfecta resulting from the substitution of glycine by valine in the pro alpha 1 (I) chain of type I procollagen. (PubMed id 1613761)1, 2 Cole W.G.... Fortune D.W. (J. Med. Genet. 1992)
    173. Mild dominant osteogenesis imperfecta with intrafamilial variability: the cause is a serine for glycine alpha 1(I) 901 substitution in a type-I collagen gene. (PubMed id 1634225)1, 2 Mottes M.... Cetta G. (Hum. Genet. 1992)
    174. Substitution of cysteine for glycine-alpha 1-691 in the pro alpha 1(I) chain of type I procollagen in a proband with lethal osteogenesis imperfecta destabilizes the triple helix at a site C-terminal to the substitution. (PubMed id 1953667)1, 2 Steinmann B....Prockop D.J. (Biochem. J. 1991)
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    180. The substitution of arginine for glycine 85 of the alpha 1(I) procollagen chain results in mild osteogenesis imperfecta. The mutation provides direct evidence for three discrete domains of cooperative melting of intact type I collagen. (PubMed id 1718984)1, 2 Deak S.B.... MacKenzie J.W. (J. Biol. Chem. 1991)
    181. A type I collagen with substitution of a cysteine for glycine-748 in the alpha 1(I) chain copolymerizes with normal type I collagen and can generate fractallike structures. (PubMed id 2036375)1, 2 Kadler K.E....Prockop D.J. (Biochemistry 1991)
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    183. Substitutions for glycine alpha 1-637 and glycine alpha 2-694 of type I procollagen in lethal osteogenesis imperfecta. The conformational strain on the triple helix introduced by a glycine substitution can be transmitted along the helix. (PubMed id 1874719)1, 2 Tsuneyoshi T.... Prockop D.J. (J. Biol. Chem. 1991)
    184. Mutations that substitute serine for glycine alpha 1-598 and glycine alpha 1-631 in type I procollagen. The effects on thermal unfolding of the triple helix are position-specific and demonstrate that the protein unfolds through a series of cooperative blocks. (PubMed id 2116413)1, 2 Westerhausen A.... Prockop D.J. (J. Biol. Chem. 1990)
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    193. Substitution of serine for alpha 1(I)-glycine 844 in a severe variant of osteogenesis imperfecta minimally destabilizes the triple helix of type I procollagen. The effects of glycine substitutions on thermal stability are either position of amino acid specific. (PubMed id 2511192)1, 2 Pack M.... Prockop D.J. (J. Biol. Chem. 1989)
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    269. A haplotype derived from the common variants at the -1997G/T and Sp1 binding site of the COL1A1 gene influences risk of postmenopausal osteoporosis in India. (PubMed id 22057139)1 Singh M....Kaur T. (Rheumatol. Int. 2013)
    270. Connective tissue growth factor induces collagen I expression in human lung fibroblasts through the Rac1/MLK3/JNK/AP-1 pathway. (PubMed id 23906792)1 Lin C.H....Chen B.C. (Biochim. Biophys. Acta 2013)
    271. Comparative analysis of basal lamina type IV collagen I+ chains, matrix metalloproteinases-2 and -9 expressions in oral dysplasia and invasive carcinoma. (PubMed id 22694915)1 Tamamura R....Nagai N. (Acta Histochem. 2013)
    272. Helical mutations in type I collagen that affect the processing of the amino-propeptide result in an Osteogenesis Imperfecta/Ehlers-Danlos Syndrome overlap syndrome. (PubMed id 23692737)1 Malfait F....De Paepe A. (Orphanet J Rare Dis 2013)
    273. JAG1 and COL1A1 polymorphisms and haplotypes in relation to bone mineral density variations in postmenopausal Mexican-Mestizo Women. (PubMed id 22174012)1 Rojano-MejA-a D....Canto P. (Age (Dordr) 2013)
    274. Apelin-13 induces proliferation, migration, and collagen I mRNA expression in human RPE cells via PI3K/Akt and MEK/Erk signaling pathways. (PubMed id 24227918)1 Qin D....Jiang Y.R. (Mol. Vis. 2013)
    275. Prospective study of urinary and serum cross-linked N-telopeptide of type I collagen (NTx) for diagnosis of bone metastasis in patients with lung cancer. (PubMed id 23276824)1 Tamiya M....Hirashima T. (Clin Lung Cancer 2013)
    276. Solid-state NMR study reveals collagen I structural modifications of amino acid side chains upon fibrillogenesis. (PubMed id 23341452)1 De Sa Peixoto P....Mosser G. (J. Biol. Chem. 2013)
    277. Association between osteoporosis and polymorphisms of the bone Gla protein, estrogen receptor 1, collagen 1-A1 and calcitonin receptor genes in Turkish postmenopausal women. (PubMed id 23137636)1 Tural S....Tomak L. (Gene 2013)
    278. Human brain arteriovenous malformations are associated with interruptions in elastic fibers and changes in collagen content. (PubMed id 23344861)1 Guo Y....Zhao Y.L. (Turk Neurosurg 2013)
    279. Prenatal diagnosis of recurrent autosomal dominant osteogenesis imperfecta associated with unaffected parents and paternal gonadal mosaicism. (PubMed id 23548228)1 Chen C.P....Wang W. (amp 2013)
    280. Skeletal clinical characteristics of osteogenesis imperfecta caused by haploinsufficiency mutations in COL1A1. (PubMed id 23529829)1 Ben Amor I.M....Rauch F. (J. Bone Miner. Res. 2013)
    281. Suppression of type I collagen in human scleral fibroblasts treated with extremely low-frequency electromagnetic fields. (PubMed id 23592926)1 Wang J....Zhu H. (Mol. Vis. 2013)
    282. Osterix induces Col1a1 gene expression through binding to Sp1 sites in the bone enhancer and proximal promoter regions. (PubMed id 23159876)1 OrtuA+o M.J....Ventura F. (Bone 2013)
    283. SPARC/SFN interaction, suppresses type I collagen in dermal fibroblasts. (PubMed id 22422640)1 Chavez-MuA+oz C....Ghahary A. (J. Cell. Biochem. 2012)
    284. The identification of novel mutations in COL1A1, COL1A2, and LEPRE1 genes in Chinese patients with osteogenesis imperfecta. (PubMed id 21667357)1 Zhang Z.L....Fu W.Z. (J. Bone Miner. Metab. 2012)
    285. Increased expression of IL-6 family members in tendon pathology. (PubMed id 22337942)1 Legerlotz K....Riley G.P. (Rheumatology (Oxford) 2012)
    286. Atrophic dermatofibrosarcoma protuberans: report of a case demonstrated by detecting COL1A1-PDGFB rearrangement. (PubMed id 23199263)1 Qiao J....Fang H. (Diagn Pathol 2012)
    287. [Studies of type I collagen (COL1A1) alpha1 chain in patients with osteogenesis imperfecta]. (PubMed id 22679784)1 Nadyrshina D.D....Khusnutdinova E.K. (Genetika 2012)
    288. Elevated pre-operative serum peptides for collagen I and III synthesis result in post-surgical atrial fibrillation. (PubMed id 23040566)1 Swartz M.F....Jalife J. (J. Am. Coll. Cardiol. 2012)
    289. Effect of lactoferrin on osteogenic differentiation of human adipose stem cells. (PubMed id 21713451)1 Ying X....Zhu Lu C. (Int Orthop 2012)
    290. Recurrence of osteogenesis imperfecta due to maternal mosaicism of a novel COL1A1 mutation. (PubMed id 22987783)1 Yamada T....Minakami H. (Am. J. Med. Genet. A 2012)
    291. Genetic association with overall survival of taxane-treated lung cancer patients - a genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study. (PubMed id 23006423)1 Niu N....Wang L. (BMC Cancer 2012)
    292. The p65 subunit of NF-I_B inhibits COL1A1 gene transcription in human dermal and scleroderma fibroblasts through its recruitment on promoter by protein interaction with transcriptional activators (c-Krox, Sp1, and Sp3). (PubMed id 22139845)1 Beauchef G....Galera P. (J. Biol. Chem. 2012)
    293. Biochemical markers of bone turnover and clinical outcomes in men with prostate cancer. (PubMed id 21163673)1 Saad F....Smith M.R. (Urol. Oncol. 2012)
    294. No evidence for disturbed COL1A1 and A2 expression in otosclerosis. (PubMed id 22130917)1 Csomor P....Karosi T. (Eur Arch Otorhinolaryngol 2012)
    295. Collagen type I and decorin expression in tenocytes depend on the cell isolation method. (PubMed id 22871215)1 WagenhAouser M.U....MA1ller P.E. (BMC Musculoskelet Disord 2012)
    296. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    297. Supernatants from culture of type I collagen-stimulated PBMC from patients with cutaneous systemic sclerosis versus localized scleroderma demonstrate suppression of MMP-1 by fibroblasts. (PubMed id 22367096)1 Brown M....Hasty K.A. (Clin. Rheumatol. 2012)
    298. Distribution of three SNPs related to low bone mineral density in Amerindian groups and Mestizos from Mexico. (PubMed id 22434650)1 NuA+o-Arana I....Rangel-Villalobos H. (Am. J. Hum. Biol. 2012)
    299. Candidate DNA methylation drivers of acquired cisplatin resistance in ovarian cancer identified by methylome and expression profiling. (PubMed id 22249249)1 Zeller C....Brown R. (Oncogene 2012)
    300. Plasma hydroxyproline, MMP-7 and collagen I as novel predictive risk markers of hepatobiliary disease-associated cholangiocarcinoma. (PubMed id 21935919)1 Prakobwong S....Pinlaor S. (Int. J. Cancer 2012)
    301. Knockdown of electron transfer flavoprotein I^ subunit reduced TGF-I^-induced I+-SMA mRNA expression but not COL1A1 in fibroblast-populated three-dimensional collagen gel cultures. (PubMed id 23068445)1 Hirokawa S....Shimosaka M. (J. Dermatol. Sci. 2012)
    302. COL1A1 haplotypes and hip fracture. (PubMed id 22190259)1 Urreizti R....Grinberg D. (J. Bone Miner. Res. 2012)
    303. Mechanical stretch increases Smad3-dependent CCN2 expression in inner meniscus cells. (PubMed id 22576977)1 Furumatsu T....Ozaki T. (J. Orthop. Res. 2012)
    304. TGF-I^-mediated downregulation of microRNA-196a contributes to the constitutive upregulated type I collagen expression in scleroderma dermal fibroblasts. (PubMed id 22379029)1 Honda N....Ihn H. (J. Immunol. 2012)
    305. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    306. Suppression of type I collagen expression by miR-29b via PI3K, Akt, and Sp1 pathway in human Tenon's fibroblasts. (PubMed id 22297492)1 Li N....Fan F. (amp 2012)
    307. Impact of collagen crosslinking on the second harmonic generation signal and the fluorescence lifetime of collagen autofluorescence. (PubMed id 21564311)1 Lutz V....Fischer F. (Skin Res Technol 2012)
    308. COL1A1 association and otosclerosis: a meta-analysis. (PubMed id 22489040)1 Schrauwen I....Van Camp G. (Am. J. Med. Genet. A 2012)
    309. Type I collagen and matrix metalloproteinase 1, 3 and 9 gene polymorphisms in the predisposition to pelvic organ prolapse. (PubMed id 22210296)1 Ferrari M.M....Meschia M. (Arch. Gynecol. Obstet. 2012)
    310. Fibrillar type I collagen matrices enhance metastasis/invasion of ovarian epithelial cancer via I^1 integrin and PTEN signals. (PubMed id 23013730)1 Shen Y....Li F. (Int. J. Gynecol. Cancer 2012)
    311. A novel splicing mutation in COL1A1 gene caused type I osteogenesis imperfecta in a Chinese family. (PubMed id 22565191)1 Peng H....Hu Z. (Gene 2012)
    312. Variable expressivity of osteogenesis imperfecta in a Brazilian family due to p.G1079S mutation in the COL1A1 gene. (PubMed id 23079818)1 Moraes M.V....Paula F. (Genet. Mol. Res. 2012)
    313. X4 Human immunodeficiency virus type 1 gp120 promotes human hepatic stellate cell activation and collagen I expression through interactions with CXCR4. (PubMed id 22479424)1 Hong F....Bansal M.B. (PLoS ONE 2012)
    314. Identification of novel ATP13A2 interactors and their role in I+-synuclein misfolding and toxicity. (PubMed id 22645275)1 Usenovic M....Krainc D. (Hum. Mol. Genet. 2012)
    315. Genetic predispositions and the short- and long-term effects of hormonal therapy on bone mineral density in girls with functional hypothalamic amenorrhoea. (PubMed id 23338998)1 SowiA8ska-Przepiera E....Syrenicz A. (Endokrynol Pol 2012)
    316. Inhibitory effects of the transcription factor Ets-1 on the expression of type I collagen in TGF-I^1-stimulated renal epithelial cells. (PubMed id 22829018)1 Okano K....Nitta K. (Mol. Cell. Biochem. 2012)
    317. Genetic factors responsible for long bone fractures non-union. (PubMed id 20730440)1 SzczA9sny G....GA^recki A. (Arch Orthop Trauma Surg 2011)
    318. [Effect of Danshensu on fibronectin and collagen-1 secretion induced by high glucose in human peritoneal mesothelial cells]. (PubMed id 21311138)1 Zhang H....Cai X. (Zhong Nan Da Xue Xue Bao Yi Xue Ban 2011)
    319. Effects of COLIA1 polymorphisms and haplotypes on perimenopausal bone mass, postmenopausal bone loss and fracture risk. (PubMed id 20571774)1 GonzA!lez-Bofill N....Langdahl B.L. (Osteoporos Int 2011)
    320. Comparative vertebrate evolutionary analyses of type I collagen: potential of COL1a1 gene structure and intron variation for common bone-related diseases. (PubMed id 20724381)1 Stover D.A. and Verrelli B.C. (Mol. Biol. Evol. 2011)
    321. [Investigation of mRNA expression of collagen genes in oral squamous cell carcinoma and paired normal tissue]. (PubMed id 21764694)1 LA1 X.Z....Zhang C.P. (Nan Fang Yi Ke Da Xue Xue Bao 2011)
    322. Cranial base abnormalities in osteogenesis imperfecta: phenotypic and genotypic determinants. (PubMed id 20721936)1 Cheung M.S....Rauch F. (J. Bone Miner. Res. 2011)
    323. Isolation of mesenchymal stem cells from human ligamentum flavum: implicating etiology of ligamentum flavum hypertrophy. (PubMed id 21343850)1 Chen Y.T....Hung S.C. (Spine 2011)
    324. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    325. Plasminogen activation by airway smooth muscle is regulated by type I collagen. (PubMed id 20693403)1 Schuliga M....Stewart A.G. (Am. J. Respir. Cell Mol. Biol. 2011)
    326. Sp1 collagen I A1 polymorphism in women with stress urinary incontinence. (PubMed id 21336691)1 Sioutis D....Liapis A. (Int Urogynecol J 2011)
    327. Sequence environment of mutation affects stability and folding in collagen model peptides of osteogenesis imperfecta. (PubMed id 20235194)1 Bryan M.A....Brodsky B. (Biopolymers 2011)
    328. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    329. Heterozygous C-propeptide mutations in COL1A1: osteogenesis imperfecta type IIC and dense bone variant. (PubMed id 21834035)1 Takagi M....Hasegawa T. (Am. J. Med. Genet. A 2011)
    330. Nonlinear optical properties of type I collagen fibers studied by polarization dependent second harmonic generation microscopy. (PubMed id 21970315)1 Tuer A.E....Barzda V. (J Phys Chem B 2011)
    331. Hydroxylation of recombinant human collagen type I alpha 1 in transgenic maize co-expressed with a recombinant human prolyl 4-hydroxylase. (PubMed id 21702901)1 Xu X....Wang K. (BMC Biotechnol. 2011)
    332. Biological effect of resorbable plates on normal osteoblasts and osteoblasts derived from Pfeiffer syndrome. (PubMed id 21558934)1 Palmieri A....Carinci F. (J Craniofac Surg 2011)
    333. Osteogenesis imperfecta missense mutations in collagen: structural consequences of a glycine to alanine replacement at a highly charged site. (PubMed id 22054507)1 Xiao J....Brodsky B. (Biochemistry 2011)
    334. Identification of t(17;22)(q22;q13) (COL1A1/PDGFB) in dermatofibrosarcoma protuberans by fluorescence in situ hybridization in paraffin-embedded tissue microarrays. (PubMed id 21111450)1 Segura S....Pujol R.M. (Hum. Pathol. 2011)
    335. Post-transcriptional up-regulation of miR-21 by type I collagen. (PubMed id 21647970)1 Li C....Shan B. (Mol. Carcinog. 2011)
    336. Association of estrogen receptor alpha and collagen type I alpha 1 gene polymorphisms with bone mineral density in postmenopausal women. (PubMed id 20532479)1 Erdogan M.O....Colak E. (Osteoporos Int 2011)
    337. Tachycardia of atrial myocytes induces collagen expression in atrial fibroblasts through transforming growth factor I^1. (PubMed id 21134900)1 Tsai C.T....Lin J.L. (Cardiovasc. Res. 2011)
    338. Deposition of apatite in mineralizing vertebrate extracellular matrices: A model of possible nucleation sites on type I collagen. (PubMed id 21405976)1 Silver F.H. and Landis W.J. (Connect. Tissue Res. 2011)
    339. Growth hormone is positively associated with surrogate markers of bone turnover during puberty. (PubMed id 21535073)1 Russell M....Misra M. (Clin. Endocrinol. (Oxf) 2011)
    340. Sp1 polymorphism in collagen I I+1 gene is associated with osteoporosis in lumbar spine of Mexican women. (PubMed id 20146006)1 FalcA^n-RamA-rez E....ValdAcs-Flores M. (Mol. Biol. Rep. 2011)
    341. An association study of the COL1A1 gene and high myopia in a Han Chinese population. (PubMed id 22219633)1 Zhang D....Yang Z. (Mol. Vis. 2011)
    342. A novel role of vimentin filaments: binding and stabilization of collagen mRNAs. (PubMed id 21746880)1 Challa A.A. and Stefanovic B. (Mol. Cell. Biol. 2011)
    343. Increased type I and V collagen expression in uterine leiomyomas during the menstrual cycle. (PubMed id 21215393)1 Iwahashi M. and Muragaki Y. (Fertil. Steril. 2011)
    344. An SP1-binding site polymorphism in the COLIAI gene and osteoporosis in Egyptian patients with thalassemia major. (PubMed id 21178584)1 Hamed H.M....Abd-Elgawad M.F. (amp 2011)
    345. Fibrotic response in fibroblasts from congenital disorders of glycosylation. (PubMed id 21029365)1 Lecca M.R....Hennet T. (J. Cell. Mol. Med. 2011)
    346. Association of COL1A1 and TGFB1 polymorphisms with otosclerosis in a Tunisian population. (PubMed id 21777208)1 Khalfallah A....Masmoudi S. (Ann. Hum. Genet. 2011)
    347. Mutation characteristics in type I collagen genes in Chinese patients with osteogenesis imperfecta. (PubMed id 21341209)1 Yang Z....Wang L.T. (Genet. Mol. Res. 2011)
    348. No association between polymorphisms and haplotypes of COL1A1 and COL1A2 genes and osteoporotic fracture in postmenopausal Chinese women. (PubMed id 21602843)1 Hu W.W....Zhang Z.L. (Acta Pharmacol. Sin. 2011)
    349. Polymorphisms in the 5' flank of COL1A1 gene and osteoporosis: meta-analysis of published studies. (PubMed id 20798928)1 Jin H....Ralston S.H. (Osteoporos Int 2011)
    350. Suppression of type I collagen production by microRNA-29b in cultured human stellate cells. (PubMed id 19913496)1 Ogawa T....Kawada N. (Biochem. Biophys. Res. Commun. 2010)
    351. [Genetic risk markers of low bone mineral density in cystic fibrosis children]. (PubMed id 21462477)1 Norek A....Bal J. (Med Wieku Rozwoj 2010)
    352. Molecular mechanism of type I collagen homotrimer resistance to mammalian collagenases. (PubMed id 20463013)1 Han S....Leikin S. (J. Biol. Chem. 2010)
    353. Genotype-phenotype correlations in nonlethal osteogenesis imperfecta caused by mutations in the helical domain of collagen type I. (PubMed id 20087402)1 Rauch F....Glorieux F.H. (Eur. J. Hum. Genet. 2010)
    354. Effects of individual control of pH and hypoxia in chondrocyte culture. (PubMed id 19813243)1 Das R.H....Jahr H. (J. Orthop. Res. 2010)
    355. Altered oxidative stress responses and increased type I collagen expression in bicuspid aortic valve patients. (PubMed id 21095332)1 Phillippi J.A....Gleason T.G. (Ann. Thorac. Surg. 2010)
    356. Association of collagen type I alpha1 gene polymorphism with bone mineral density in osteoporotic women in Serbia. (PubMed id 20509788)1 Trajkovic K....Kanazir S. (J Womens Health (Larchmt) 2010)
    357. Detection of COL1A1-PDGFB fusion transcripts in dermatofibrosarcoma protuberans. (PubMed id 20406730)1 Nakanishi G....Tanioka M. (Eur J Dermatol 2010)
    358. Urinary N-telopeptide (uNTx) is an independent prognostic factor for overall survival in patients with bone metastases from castration-resistant prostate cancer. (PubMed id 20181574)1 Rajpar S....Fizazi K. (Ann. Oncol. 2010)
    359. AP-1 overexpression impairs corticosteroid inhibition of collagen production by fibroblasts isolated from asthmatic subjects. (PubMed id 20543003)1 Jacques E....Chakir J. (Am. J. Physiol. Lung Cell Mol. Physiol. 2010)
    360. Procollagen I amino-terminal propeptide as a potential marker for multiple myeloma. (PubMed id 20045402)1 Kowalska M....Kaminska J. (Clin. Biochem. 2010)
    361. Plaque-like CD34-positive dermal fibroma (&quot;medallion-like dermal dendrocyte hamartoma&quot;): clinicopathologic, immunohistochemical, and molecular analysis of 5 cases emphasizing its distinction from superficial, plaque-like dermatofibrosarcoma protuberans. (PubMed id 20061935)1 Kutzner H....Requena L. (Am. J. Surg. Pathol. 2010)
    362. Analysis of correlation between the process of thyroid fibrosis and TGFB1 gene expression level in fine-needle aspiration biopsy (FNAB) thyroid specimens collected from patients with Hashimoto's thyroiditis and non-toxic goitre. (PubMed id 20191437)1 Cyniak-Magierska A....LewiA8ski A. (amp 2010)
    363. TGF-I^1-treated ADSCs-CM promotes expression of type I collagen and MMP-1, migration of human skin fibroblasts, and wound healing in vitro and in vivo. (PubMed id 21042785)1 Cho J.W....Lee K.S. (Int. J. Mol. Med. 2010)
    364. [Analysis of polymorphism of bone metabolism genes and evaluation of the risk of osteopenia in cosmonauts]. (PubMed id 21033393)1 Oganov V.S....VoA-tulevich L.V. (Aviakosm Ekolog Med 2010)
    365. MMP-12 catalytic domain recognizes and cleaves at multiple sites in human skin collagen type I and type III. (PubMed id 19932771)1 Taddese S....Schmelzer C.E. (Biochim. Biophys. Acta 2010)
    366. [Influence of mutation of -1997G--&gt;T of COL I A1 gene on the biochemical function of osteoblast]. (PubMed id 21302452)1 Cao F....Pei F.X. (Sichuan Da Xue Xue Bao Yi Xue Ban 2010)
    367. Function analysis of the promoter gene of the human COL1A1 and analysis of DNA binding factors in the transcription enhancement region. (PubMed id 20435445)1 Yoshida T....Hatamochi A. (J. Dermatol. Sci. 2010)
    368. No correlation between the molecular subtype of COL1A1-PDGFB fusion gene and the clinico-histopathological features of dermatofibrosarcoma protuberans. (PubMed id 19890351)1 Giacchero D....Pedeutour F. (J. Invest. Dermatol. 2010)
    369. Applying harmonic optical microscopy for spatial alignment of atrial collagen fibers. (PubMed id 21085489)1 Chiu Y.W....Ho Y.L. (PLoS ONE 2010)
    370. Effects of antisense transforming growth factor-beta1 gene transfer on the biological activities of tendon sheath fibroblasts. (PubMed id 20704113)1 Xia C....Tian S. (Orthopedics 2010)
    371. Are integrin alpha(2)beta(1), glycoprotein Ib and vWf levels correlated with their contributions to platelet adhesion on collagen under high-shear flow? (PubMed id 20063990)1 Jung S.M....Moroi M. (Platelets 2010)
    372. Metastatic outgrowth encompasses COL-I, FN1, and POSTN up-regulation and assembly to fibrillar networks regulating cell adhesion, migration, and growth. (PubMed id 20489157)1 Soikkeli J....HAPlttAo E. (Am. J. Pathol. 2010)
    373. Effects of leptin on the expression of alpha1 (I) collagen gene in human osteoblast-like MG63 cells. (PubMed id 20651840)1 Peng M....Yu X. (Biochem. Cell Biol. 2010)
    374. [Study on the correlation between the polymorphism of --1997g/T site of collagen I alpha 1 gene and bone mineral density in postmenopausal women]. (PubMed id 20369485)1 Li Y....Pei F.X. (Sichuan Da Xue Xue Bao Yi Xue Ban 2010)
    375. Complete COL1A1 allele deletions in osteogenesis imperfecta. (PubMed id 21113976)1 van Dijk F.S....Pals G. (Genet. Med. 2010)
    376. Involvement of a forkhead transcription factor, FOXO1A, in UV-induced changes of collagen metabolism. (PubMed id 19675556)1 Tanaka H....Nakata S. (J. Investig. Dermatol. Symp. Proc. 2009)
    377. Keratinocyte-conditioned media regulate collagen expression in dermal fibroblasts. (PubMed id 18787532)1 Ghaffari A....Ghahary A. (J. Invest. Dermatol. 2009)
    378. A potential role of collagens expression in distinguishing between premalignant and malignant lesions in stomach. (PubMed id 19306436)1 Zhao Y....Si J. (Anat Rec (Hoboken) 2009)
    379. Involvement of 90-kuD ribosomal S6 kinase in collagen type I expression in rat hepatic fibrosis. (PubMed id 19418583)1 Yang M.F....Zhu R.M. (World J. Gastroenterol. 2009)
    380. Role of MAPK in mechanical force-induced up-regulation of type I collagen and osteopontin in human gingival fibroblasts. (PubMed id 18682895)1 Jeon Y.M....Lee J.C. (Mol. Cell. Biochem. 2009)
    381. [Expression and pathobiological significance of Col I, Col IV and Fn in laryngeal squamous cell carcinomas]. (PubMed id 20359090)1 Zhang H....Shang W. (Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2009)
    382. [Human osteoblasts response to different magnitudes of mechanical stimulation in vitro]. (PubMed id 19595020)1 Zhu J.F....Bai X.L. (Zhonghua Wai Ke Za Zhi 2009)
    383. Mineral deposition in the extracellular matrices of vertebrate tissues: identification of possible apatite nucleation sites on type I collagen. (PubMed id 18703872)1 Landis W.J. and Silver F.H. (Cells Tissues Organs (Print) 2009)
    384. Mesenchymal stem cells produce Wnt isoforms and TGF-beta1 that mediate proliferation and procollagen expression by lung fibroblasts. (PubMed id 19734317)1 Salazar K.D....Brody A.R. (Am. J. Physiol. Lung Cell Mol. Physiol. 2009)
    385. Promotion of tumor cell migration by extracellular matrix proteins in human pancreatic cancer. (PubMed id 19893454)1 Ryschich E....Schmidt J. (Pancreas 2009)
    386. Mechanical force induces type I collagen expression in human periodontal ligament fibroblasts through activation of ERK/JNK and AP-1. (PubMed id 19206162)1 Kook S.H....Lee J.C. (J. Cell. Biochem. 2009)
    387. Polymorphism of a COLIA1 gene Sp1 binding site in Korean women with pelvic organ prolapse. (PubMed id 19718407)1 Cho H.J....Bai S.W. (Yonsei Med. J. 2009)
    388. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    389. Dermatofibrosarcoma protuberans: clinical, pathological, and genetic (COL1A1-PDGFB ) study with therapeutic implications. (PubMed id 19635106)1 Llombart B....GuillAcn C. (Histopathology 2009)
    390. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    391. A G560S mutation in alpha1 (I) collagen causes familial osteogenesis imperfecta type IV. (PubMed id 19751715)1 Cui Y.X....Li X.J. ( international journal of clinical chemistry 2009)
    392. Angiotensin II induces type I collagen gene expression in human dermal fibroblasts through an AP-1/TGF-beta1-dependent pathway. (PubMed id 19465003)1 Tang H.T....Xia Z.F. (Biochem. Biophys. Res. Commun. 2009)
    393. [Smad7 inhibits collagen expression in human hepatic satellite cells in vitro]. (PubMed id 19861282)1 Tang L.X....Tang J.J. (Nan Fang Yi Ke Da Xue Xue Bao 2009)
    394. Bone turnover and type I collagen C-telopeptide isomerization in adult osteogenesis imperfecta: associations with collagen gene mutations. (PubMed id 19071236)1 Garnero P....Chevrel G. (Bone 2009)
    395. Transforming growth factor-beta1 up-regulation of human alpha(1)(I) collagen is mediated by Sp1 and Smad2 transacting factors. (PubMed id 19558215)1 Sysa P....Mezey E. (DNA Cell Biol. 2009)
    396. Genetic analysis of Alzheimer's disease in the Uppsala Longitudinal Study of Adult Men. (PubMed id 19141999)4 Giedraitis V....Glaser A. (Dement Geriatr Cogn Disord 2009)
    397. Audiometric, surgical, and genetic findings in 15 ears of patients with osteogenesis imperfecta. (PubMed id 19358256)1 Swinnen F.K....Dhooge I.J. (Laryngoscope 2009)
    398. Potential utility of high preoperative levels of serum type I collagen markers in postmenopausal women with primary hyperparathyroidism with respect to their short-term variations after parathyroidectomy. (PubMed id 19172220)1 Boudou P....Souberbielle J.C. (J. Bone Miner. Metab. 2009)
    399. Identification of differentially expressed genes in papillary thyroid cancers. (PubMed id 19259350)1 Lee K.Y....Kim J.M. (Yonsei Med. J. 2009)
    400. AGEs and glucose levels modulate type I and III procollagen mRNA synthesis in dermal fibroblasts cells culture. (PubMed id 18401458)1 Andreea S.I....Anca D. (Exp Diabetes Res 2008)
    401. [Effect of advanced glycation end products on the human gingival fibroblast proliferation and type I collagen synthesis]. (PubMed id 18380967)1 Qi L.Y....Zhou Y. (Zhonghua Kou Qiang Yi Xue Za Zhi 2008)
    402. Akt blockade downregulates collagen and upregulates MMP1 in human dermal fibroblasts. (PubMed id 18323784)1 Bujor A.M....Trojanowska M. (J. Invest. Dermatol. 2008)
    403. Bone mineral density and bone turnover in patients with psoriatic arthritis. (PubMed id 17876648)1 Borman P....Bodur H. (Clin. Rheumatol. 2008)
    404. The clinical significance of soluble human leukocyte antigen class-I, ICTP, and RANKL molecules in multiple myeloma patients. (PubMed id 18361931)1 SchA1tt P....Grosse-Wilde H. (Hum. Immunol. 2008)
    405. Defective C-propeptides of the proalpha2(I) chain of type I procollagen impede molecular assembly and result in osteogenesis imperfecta. (PubMed id 18375391)1 Pace J.M....Byers P.H. (J. Biol. Chem. 2008)
    406. Evidence that abnormal high bone mineralization in growing children with osteogenesis imperfecta is not associated with specific collagen mutations. (PubMed id 18311573)1 Roschger P....Rauch F. (Calcif. Tissue Int. 2008)
    407. A novel arginine-to-cysteine substitution in the triple helical region of the alpha1(I) collagen chain in a family with an osteogenesis imperfecta/Ehlers-Danlos phenotype. (PubMed id 18028452)1 Lund A....Schwartz M. (Clin. Genet. 2008)
    408. Predicting the clinical lethality of osteogenesis imperfecta from collagen glycine mutations. (PubMed id 18412368)1 Bodian D.L....Klein T.E. (Biochemistry 2008)
    409. Genomic gains of COL1A1-PDFGB occur in the histologic evolution of giant cell fibroblastoma into dermatofibrosarcoma protuberans. (PubMed id 18069662)1 Macarenco R.S....Oliveira A.M. (amp 2008)
    410. CIITA mediates interferon-gamma repression of collagen transcription through phosphorylation-dependent interactions with co-repressor molecules. (PubMed id 17991736)1 Xu Y....Smith B.D. (J. Biol. Chem. 2008)
    411. Incorporation of the bone marker carboxy-terminal telopeptide of type-1 collagen improves prognostic information of the International Staging System in newly diagnosed symptomatic multiple myeloma. (PubMed id 18580957)1 Jakob C....Sezer O. (Leukemia 2008)
    412. [Analysis of the association of the genotype COLIA1 with arterial fluid markers in patients with chronic obstructive pulmonary disease and bronchial asthma]. (PubMed id 19110771)1 Gel'tser B.I....Motkina E.V. (Probl Tuberk Bolezn Legk 2008)
    413. Differential unfolding of alpha1 and alpha2 chains in type I collagen and collagenolysis. (PubMed id 18644377)1 Nerenberg P.S. and Stultz C.M. (J. Mol. Biol. 2008)
    414. [Regulation of collagen type I and fibronectin mRNA expression by mechanical stress in cultured human periodontal ligament fibroblasts]. (PubMed id 19031824)1 Zhu Q.D....Hu J. (Zhonghua Kou Qiang Yi Xue Za Zhi 2008)
    415. Gene expression profiling identifies genes predictive of oral squamous cell carcinoma. (PubMed id 18669583)1 Chen C....Zhao L.P. (amp 2008)
    416. [Expression of myocardial collagen I in early acute myocardial ischemic of human]. (PubMed id 18709850)1 Gao S.H....Huang F.J. (Fa Yi Xue Za Zhi 2008)
    417. Prostaglandin E(2) inhibits collagen expression and proliferation in patient-derived normal lung fibroblasts via E prostanoid 2 receptor and cAMP signaling. (PubMed id 17028262)1 Huang S....Peters-Golden M. (Am. J. Physiol. Lung Cell Mol. Physiol. 2007)
    418. Phagocytosis and remodeling of collagen matrices. (PubMed id 17276428)1 Abraham L.C....Kaplan D.L. (Exp. Cell Res. 2007)
    419. [Structure-based design and biosynthesis of collagen proteins]. (PubMed id 17460886)1 Du C.L. and Yao J.M. (Sheng Wu Gong Cheng Xue Bao 2007)
    420. Enhanced alpha 1(I) mRNA expression in frozen shoulder and dupuytren tissue. (PubMed id 18024269)1 Kilian O....Schnettler R. (Eur. J. Med. Res. 2007)
    421. TGF-beta-regulated collagen type I accumulation: role of Src-based signals. (PubMed id 17135298)1 Mishra R....Simonson M.S. (Am. J. Physiol., Cell Physiol. 2007)
    422. Y-position cysteine substitution in type I collagen (alpha1(I) R888C/p.R1066C) is associated with osteogenesis imperfecta/Ehlers- Danlos syndrome phenotype. (PubMed id 17206620)2 Cabral W.A.... Marini J.C. (Hum. Mutat. 2007)
    423. A rapid one-tube PCR method for simultaneously differentiating homozygotes and heterozygotes of the Sp1 binding site polymorphism in collagen type Ialpha1. (PubMed id 17187960)1 Lundberg G.A. (Mol. Cell. Probes 2007)
    424. Predictive value of osteocalcin and beta-CrossLaps in metastatic breast cancer. (PubMed id 17889845)1 Salem A.M....Hamdy R. (Clin. Biochem. 2007)
    425. Type I collagen is a genetic modifier of matrix metalloproteinase 2 in murine skeletal development. (PubMed id 17440987)7 Egeblad M....Coussens L.M. (Dev. Dyn. 2007)
    426. TNF-alpha suppresses alpha-smooth muscle actin expression in human dermal fibroblasts: an implication for abnormal wound healing. (PubMed id 17554369)1 Goldberg M.T....Garner W.L. (J. Invest. Dermatol. 2007)
    427. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
    428. Streptococcal protein FOG, a novel matrix adhesin interacting with collagen I in vivo. (PubMed id 16278217)1 Nitsche D.P....MAPrgelin M. (J. Biol. Chem. 2006)
    429. Exogenous nitric oxide enhances the synthesis of type I collagen and heat shock protein 47 by normal human dermal fibroblasts. (PubMed id 16171977)1 Obayashi K....Masaki H. (J. Dermatol. Sci. 2006)
    430. Leptin enhances alpha1(I) collagen gene expression in LX-2 human hepatic stellate cells through JAK-mediated H2O2-dependent MAPK pathways. (PubMed id 16173077)1 Cao Q....Lieber C.S. (J. Cell. Biochem. 2006)
    431. Modeling of serum C-telopeptide levels with daily and monthly oral ibandronate in humans. (PubMed id 16831952)1 Zaidi M....Friend K. (Ann. N. Y. Acad. Sci. 2006)
    432. Vitronectin and collagen I differentially regulate osteogenesis in mesenchymal stem cells. (PubMed id 16815299)1 Kundu A.K. and Putnam A.J. (Biochem. Biophys. Res. Commun. 2006)
    433. Hypermethylation of CpGs in the promoter of the COL1A1 gene in the aged periodontal ligament. (PubMed id 16498072)1 Ohi T....Ono T. (J. Dent. Res. 2006)
    434. CXCL12 (SDF-1) and CXCL13 (BCA-1) chemokines significantly induce proliferation and collagen type I expression in osteoblasts from osteoarthritis patients. (PubMed id 15965952)1 Lisignoli G....Facchini A. (J. Cell. Physiol. 2006)
    435. Functional diversity of lysyl hydroxylase 2 in collagen synthesis of human dermal fibroblasts. (PubMed id 16934803)1 Wu J....Brinckmann J. (Exp. Cell Res. 2006)
    436. Decreased collagen production in chronologically aged skin: roles of age-dependent alteration in fibroblast function and defective mechanical stimulation. (PubMed id 16723701)1 Varani J....Voorhees J.J. (Am. J. Pathol. 2006)
    437. Molecular mechanism of alpha 1(I)-osteogenesis imperfecta/Ehlers-Danlos syndrome: unfolding of an N-anchor domain at the N-terminal end of the type I collagen triple helix. (PubMed id 16407265)1 Makareeva E....Leikin S. (J. Biol. Chem. 2006)
    438. Tumor cell invasion of von Hippel Lindau renal cell carcinoma cells is mediated by membrane type-1 matrix metalloproteinase. (PubMed id 17140440)1 Petrella B.L. and Brinckerhoff C.E. (Mol. Cancer 2006)
    439. Alpha CTX as a biomarker of skeletal invasion of breast cancer: immunolocalization and the load dependency of urinary excretion. (PubMed id 16835341)1 Leeming D.J....Byrjalsen I. (amp 2006)
    440. Quantitation of collagen I, collagen II and aggrecan mRNA and expression of the corresponding proteins in human nucleus pulposus cells in monolayer cultures. (PubMed id 16001263)1 Preradovic A....Krugluger W. (Cell Tissue Res. 2005)
    441. Involvement of the collagen I-binding motif in the anti-angiogenic activity of pigment epithelium-derived factor. (PubMed id 16102727)1 Hosomichi J....Morita I. (Biochem. Biophys. Res. Commun. 2005)
    442. Megakaryocytes modulate osteoblast synthesis of type-l collagen, osteoprotegerin, and RANKL. (PubMed id 15794927)1 Bord S....Compston J.E. (Bone 2005)
    443. Variable impairment of wound healing in the heterozygous collagenase-resistant mouse. (PubMed id 15659034)7 Beare A.H....Ferguson M.W. (Wound Repair Regen 2005)
    444. Localization of precursor proteins and mRNA of type I and III collagens in usual interstitial pneumonia and sarcoidosis. (PubMed id 16521042)1 Kaarteenaho-Wiik R....PAoAokkAP P. (J. Mol. Histol. 2005)
    445. The significance of carboxy-terminal telopeptide of type I collagen (ICTP) and osteocalcin (OC) in assessment of bone disease in patients with multiple myeloma. (PubMed id 16263577)1 Kuliszkiewicz-Janus M....Zastawny M. (amp 2005)
    446. Mutations near amino end of alpha1(I) collagen cause combined osteogenesis imperfecta/Ehlers-Danlos syndrome by interference with N-propeptide processing. (PubMed id 15728585)1 Cabral W.A....Marini J.C. (J. Biol. Chem. 2005)
    447. Down-regulation of BRCA2 expression by collagen type I promotes prostate cancer cell proliferation. (PubMed id 15805113)1 Moro L....Greco M. (J. Biol. Chem. 2005)
    448. Anti-citrullinated collagen type I antibody is a target of autoimmunity in rheumatoid arthritis. (PubMed id 15950180)1 Suzuki A....Yamamoto K. (Biochem. Biophys. Res. Commun. 2005)
    449. Association of a -1997G--&gt;T polymorphism of the collagen Ialpha1 gene with bone mineral density in postmenopausal Japanese women. (PubMed id 16114814)4 Yamada Y....Shimokata H. (Hum. Biol. 2005)
    450. Collagen synthesis is not altered in women with stress urinary incontinence. (PubMed id 15227656)1 Chen Y....Kushner L. (Neurourol. Urodyn. 2004)
    451. RNA-binding proteins heterogeneous nuclear ribonucleoprotein A1, E1, and K are involved in post-transcriptional control of collagen I and III synthesis. (PubMed id 15514164)1 Thiele B.J....Regitz-Zagrosek V. (Circ. Res. 2004)
    452. Heterotrimeric type I collagen C-telopeptide conformation as docked to its helix receptor. (PubMed id 15581348)1 Malone J.P. and Veis A. (Biochemistry 2004)
    453. Reduced type I collagen utilization: a pathogenic mechanism in COL5A1 haplo-insufficient Ehlers-Danlos syndrome. (PubMed id 15095409)1 Wenstrup R.J....Birk D.E. (J. Cell. Biochem. 2004)
    454. Transcriptional regulation of human alpha1(I) procollagen gene in dermal fibroblasts. (PubMed id 15133851)1 Gao C.F....Kong X.T. (World J. Gastroenterol. 2004)
    455. Binding of proteins to the PDZ domain regulates proteolytic activity of HtrA1 serine protease. (PubMed id 15101818)1 Murwantoko ....Kawaichi M. (Biochem. J. 2004)
    456. Gene targeting in stem cells from individuals with osteogenesis imperfecta. (PubMed id 14976317)1 Chamberlain J.R....Russell D.W. (Science 2004)
    457. Connective tissue growth factor and igf-I are produced by human renal fibroblasts and cooperate in the induction of collagen production by high glucose. (PubMed id 14633859)1 Lam S....van Kooten C. (Diabetes 2003)
    458. Genetic effects of estrogen receptor alpha and collagen IA1 genes on the relationships of parathyroid hormone and 25 hydroxyvitamin D with bone mineral density in Caucasian women. (PubMed id 14506618)1 Sapir-Koren R....Kobyliansky E. (Metab. Clin. Exp. 2003)
    459. Type Ialpha collagen is an IGFBP-3 binding protein. (PubMed id 12735930)1 Liu B....Cohen P. (amp 2003)
    460. Dystrophic epidermolysis bullosa inversa with COL7A1 mutations and absence of GDA-J/F3 protein. (PubMed id 12787275)1 Kahofer P....Smolle J. (Pediatr Dermatol 2003)
    461. Association and linkage disequilibrium analyses suggest genetic effects of estrogen receptor alpha and collagen IA1 genes on bone mineral density in Caucasian women. (PubMed id 14562991)1 Sapir-Koren R....Kobyliansky E. (Calcif. Tissue Int. 2003)
    462. Severely impaired wound healing in the collagenase-resistant mouse. (PubMed id 12535212)7 Beare A.H....Ferguson M.W. (J. Invest. Dermatol. 2003)
    463. Effect of a cleavage-resistant collagen mutation on left ventricular remodeling. (PubMed id 12855673)7 Lindsey M.L....Lee R.T. (Circ. Res. 2003)
    464. Association between bone mineral density and candidate genes in different ethnic populations and its implications. (PubMed id 12447604)4 Gong G. and Haynatzki G. (Calcif. Tissue Int. 2003)
    465. Human acetylcholinesterase binds to mouse laminin-1 and human collagen IV by an electrostatic mechanism at the peripheral anionic site. (PubMed id 12524166)1 Johnson G. and Moore S.W. (Neurosci. Lett. 2003)
    466. Fusion of COL1A1 exon 29 with PDGFB exon 2 in a der(22)t(17;22) in a pediatric giant cell fibroblastoma with a pigmented Bednar tumor component. Evidence for age-related chromosomal pattern in dermatofibrosarcoma protuberans and related tumors. (PubMed id 12034531)1 Maire G....Pedeutour F. (Cancer Genet. Cytogenet. 2002)
    467. C-propeptide region of human pro alpha 1 type 1 collagen interacts with thioredoxin. (PubMed id 12099690)1 Matsumoto K....Yodoi J. (Biochem. Biophys. Res. Commun. 2002)
    468. Basic fibroblast growth factor autocrine loop controls human osteosarcoma phenotyping and differentiation. (PubMed id 12393937)1 Bodo M....Baroni T. (Mol. Med. 2002)
    469. A novel gain-of-function mutation of the integrin alpha2 VWFA domain. (PubMed id 11856343)1 Aquilina A....Tuckwell D. (Eur. J. Biochem. 2002)
    470. The leucine-rich repeat protein PRELP binds perlecan and collagens and may function as a basement membrane anchor. (PubMed id 11847210)1 Bengtsson E....Aspberg A. (J. Biol. Chem. 2002)
    471. Interaction of the leucine-rich repeats of polycystin-1 with extracellular matrix proteins: possible role in cell proliferation. (PubMed id 11752017)1 Malhas A.N....Price R.G. (J. Am. Soc. Nephrol. 2002)
    472. Interaction of human breast fibroblasts with collagen I increases secretion of procathepsin B. (PubMed id 12072442)1 Koblinski J.E....Sloane B.F. (J. Biol. Chem. 2002)
    473. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    474. COLIA1-PDGFB gene fusion in dermatofibrosarcoma protuberans. molecular analysis of a case with an unusual large marker containing sequences from chromosomes 7, 8, 17, 21, and 22. (PubMed id 12127408)1 Maire G....Limon J. (Cancer Genet. Cytogenet. 2002)
    475. Matrilin-2 interacts with itself and with other extracellular matrix proteins. (PubMed id 12180907)1 Piecha D....Paulsson M. (Biochem. J. 2002)
    476. Screening the proteins that interact with calpain in a human heart cDNA library using a yeast two-hybrid system. (PubMed id 12358155)1 Jiang L.Q....Chen L.Y. (Hypertens. Res. 2002)
    477. Matriptase-2, a membrane-bound mosaic serine proteinase predominantly expressed in human liver and showing degrading activity against extracellular matrix proteins. (PubMed id 12149247)1 Velasco G.... Lopez-Otin C. (J. Biol. Chem. 2002)
    478. Molecular properties of wild-type and mutant betaIG-H3 proteins. (PubMed id 11867580)1 Kim J.E....Kim I.S. (amp 2002)
    479. Characterization of the nucleation step and folding of a collagen triple-helix peptide. (PubMed id 12069607)1 Xu Y....Brodsky B. (Biochemistry 2002)
    480. The transforming growth factor-beta-inducible matrix protein (beta)ig-h3 interacts with fibronectin. (PubMed id 12034705)1 Billings P.C....Rosenbloom J. (J. Biol. Chem. 2002)
    481. The epithelial mitogen keratinocyte growth factor binds to collagens via the consensus sequence glycine-proline-hydroxyproline. (PubMed id 11973338)1 Ruehl M....Schuppan D. (J. Biol. Chem. 2002)
    482. Inhibition of type I procollagen production in photodamage: correlation between presence of high molecular weight collagen fragments and reduced procollagen synthesis. (PubMed id 12164934)1 Varani J....Voorhees J.J. (J. Invest. Dermatol. 2002)
    483. Relation of collagen type I alpha 1 (COLIA 1) and vitamin D receptor genotypes to bone mass, turnover, and fractures in early postmenopausal women and to hip fractures in elderly people. (PubMed id 11173011)1 VAolimAoki S....Kontula K. (Eur. J. Intern. Med. 2001)
    484. Pro-collagenase-1 (matrix metalloproteinase-1) binds the alpha(2)beta(1) integrin upon release from keratinocytes migrating on type I collagen. (PubMed id 11359786)1 Dumin J.A....Parks W.C. (J. Biol. Chem. 2001)
    485. Effect of a COL1A1 Sp1 binding site polymorphism on arterial pulse wave velocity: an index of compliance. (PubMed id 11566920)1 Brull D.J....Young I.S. (Hypertension 2001)
    486. Disruption of one intra-chain disulphide bond in the carboxyl-terminal propeptide of the proalpha1(I) chain of type I procollagen permits slow assembly and secretion of overmodified, but stable procollagen trimers and results in mild osteogenesis imperfecta. (PubMed id 11432962)1 Pace J.M....Byers P.H. (J. Med. Genet. 2001)
    487. Type I collagen stabilization of matrix metalloproteinase-2. (PubMed id 11368514)1 Ellerbroek S.M....Stack M.S. (Arch. Biochem. Biophys. 2001)
    488. Amplification of extracellular matrix and oncogenes in tat-transfected human salivary gland cell lines with expression of laminin, fibronectin, collagens I, III, IV, c-myc and p53. (PubMed id 11311202)1 McArthur C.P....Gustafson S. (Arch. Oral Biol. 2001)
    489. Identification of amino acid residues in bone morphogenetic protein-1 important for procollagen C-proteinase activity. (PubMed id 11283002)1 Garrigue-Antar L.... Kadler K.E. (J. Biol. Chem. 2001)
    490. A member of the Y-box protein family interacts with an upstream element in the alpha1(I) collagen gene. (PubMed id 11731270)1 Sun W....Smith B.D. (Matrix Biol. 2001)
    491. Regulation of type I collagen genes expression. (PubMed id 11143996)1 Rossert J....Dupont S. (Nephrol. Dial. Transplant. 2000)
    492. Role of the recombinant non-integrin platelet collagen receptor P65 on platelet activation induced by convulxin. (PubMed id 10772928)1 Francischetti I.M....Bon C. (Biochem. Biophys. Res. Commun. 2000)
    493. The Sp1 binding site polymorphism in the collagen type I alpha 1 (COLIA1) gene is not associated with bone mineral density in healthy children, adolescents, and young adults. (PubMed id 10913946)4 Berg J.P....Halse J. (Eur. J. Endocrinol. 2000)
    494. Structural basis of collagen recognition by integrin alpha2beta1. (PubMed id 10778855)1 Emsley J....Liddington R.C. (Cell 2000)
    495. Association of collagen type 1 alpha1 gene polymorphism with bone density in early childhood. (PubMed id 10084560)4 Sainz J....Gilsanz V. (J. Clin. Endocrinol. Metab. 1999)
    496. The dermatofibrosarcoma protuberans-associated collagen type Ialpha1/platelet-derived growth factor (PDGF) B-chain fusion gene generates a transforming protein that is processed to functional PDGF-BB. (PubMed id 10446987)1 Shimizu A....Ostman A. (Cancer Res. 1999)
    497. No association was found between collagen alphaI type 1 gene and bone density in prepubertal children. (PubMed id 10566692)4 Tao C....Cowell C.T. (J. Clin. Endocrinol. Metab. 1999)
    498. Association of a polymorphism in the collagen I alpha1 gene with osteoporosis in French women. (PubMed id 9433891)4 Roux C....Lucotte G. (Arthritis Rheum. 1998)
    499. Type I protein C deficiency in French Canadians: evidence of a founder effect and association of specific protein C gene mutations with plasma protein C levels. (PubMed id 9798967)4 Couture P.... Simard J. (Thromb. Haemost. 1998)
    500. Nidogen-2: a new basement membrane protein with diverse binding properties. (PubMed id 9733643)1 Kohfeldt E.... Timpl R. (J. Mol. Biol. 1998)
    501. Relation of alleles of the collagen type Ialpha1 gene to bone density and the risk of osteoporotic fractures in postmenopausal women. (PubMed id 9535665)2 Uitterlinden A.G....Ralston S.H. (N. Engl. J. Med. 1998)
    502. Decorin core protein fragment Leu155-Val260 interacts with TGF-beta but does not compete for decorin binding to type I collagen. (PubMed id 9675033)1 SchAPnherr E....Kresse H. (Arch. Biochem. Biophys. 1998)
    503. MMP-9 from TNF alpha-stimulated keratinocytes binds to cell membranes and type I collagen: a cause for extended matrix degradation in inflammation? (PubMed id 9878537)1 MAokelAo M....Larjava H. (Biochem. Biophys. Res. Commun. 1998)
    504. Thrombin stimulates fibroblast procollagen production via proteolytic activation of protease-activated receptor 1. (PubMed id 9639571)1 Chambers R.C....Laurent G.J. (Biochem. J. 1998)
    505. Interactions of the amino-terminal noncollagenous (NC1) domain of type VII collagen with extracellular matrix components. A potential role in epidermal-dermal adherence in human skin. (PubMed id 9169408)1 Chen M....Woodley D.T. (J. Biol. Chem. 1997)
    506. Cloning, characterization, and functional studies of a nonintegrin platelet receptor for type I collagen. (PubMed id 9239397)1 Chiang T.M.... Kang A.H. (J. Clin. Invest. 1997)
    507. Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor gamma-chain. (PubMed id 9280292)1 Gibbins J.M....Watson S.P. (FEBS Lett. 1997)
    508. A collagen-like peptide stimulates tyrosine phosphorylation of syk and phospholipase C gamma2 in platelets independent of the integrin alpha2beta1. (PubMed id 9028946)1 Asselin J....Watson S.P. (Blood 1997)
    509. The discoidin domain receptor tyrosine kinases are activated by collagen. (PubMed id 9659899)1 Vogel W.... Pawson T. (Mol. Cell 1997)
    510. The human type I collagen mutation database. (PubMed id 9016532)1 Dalgleish R. (Nucleic Acids Res. 1997)
    511. A novel association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets. (PubMed id 9295288)1 Tsuji M.... Takayama H. (J. Biol. Chem. 1997)
    512. Type I, II, III, IV, V, and VI collagens serve as extracellular ligands for the isoforms of platelet-derived growth factor (AA, BB, and AB). (PubMed id 8900172)1 Somasundaram R. and Schuppan D. (J. Biol. Chem. 1996)
    513. Interaction of biglycan with type I collagen. (PubMed id 7852349)1 SchAPnherr E....Kresse H. (J. Biol. Chem. 1995)
    514. Type II procollagen gene (COL2A1) mutation in exon 11 associated with spondyloepiphyseal dysplasia, tall stature and precocious osteoarthritis. (PubMed id 7738948)4 Bleasel J.F....Menkes C.J. (J. Rheumatol. 1995)
    515. Adhesion of human neuroblasts to HIV-1 tat. (PubMed id 8552450)1 Cornaglia-Ferraris P....Alessandri G. (Pediatr. Res. 1995)
    516. The binding of type I collagen to lymphocyte function-associated antigen (LFA) 1 integrin triggers the respiratory burst of human polymorphonuclear neutrophils. Role of calcium signaling and tyrosine phosphorylation of LFA 1. (PubMed id 7499207)1 Garnotel R....Borel J.P. (J. Biol. Chem. 1995)
    517. Low density lipoproteins bind more to type I and III collagens by negative charge-dependent mechanisms than to type IV and V collagens. (PubMed id 7945553)1 Jimi S....Takebayashi S. (Atherosclerosis 1994)
    518. Clinical correlations of osteoarthritis associated with a single-base mutation (arginine519 to cysteine) in type II procollagen gene. A newly defined pathogenesis. (PubMed id 8129781)4 Pun Y.L....Haqqi T.M. (Arthritis Rheum. 1994)
    519. Caffey Disease (PubMed id 22855962)1 Pagon R.A....Stephens K. (1993)
    520. Inhibition of fibronectin binding and fibronectin-mediated cell adhesion to collagen by a peptide from the second type I repeat of thrombospondin. (PubMed id 8468356)1 Sipes J.M....Roberts D.D. (J. Cell Biol. 1993)
    521. COL1A1/2-Related Osteogenesis Imperfecta (PubMed id 20301472)1 Pagon R.A....Stephens K. (1993)
    522. Ehlers-Danlos Syndrome, Classic Type (PubMed id 20301422)1 Pagon R.A....Stephens K. (1993)
    523. Interactions between thrombospondin and the small proteoglycan decorin: interference with cell attachment. (PubMed id 1468447)1 WinnemAPller M....Kresse H. (Eur. J. Cell Biol. 1992)
    524. Activation of expression of genes coding for extracellular matrix proteins in Tat-producing glioblastoma cells. (PubMed id 1409674)1 Taylor J.P....Amini S. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    525. Defective folding and stable association with protein disulfide isomerase/prolyl hydroxylase of type I procollagen with a deletion in the pro alpha 2(I) chain that preserves the Gly-X-Y repeat pattern. (PubMed id 1339453)1 Chessler S.D. and Byers P.H. (J. Biol. Chem. 1992)
    526. Evidence for a relationship between Ehlers-Danlos type VII C in humans and bovine dermatosparaxis. (PubMed id 1303238)1 Nusgens B.V....LapiA"re C.M. (Nat. Genet. 1992)
    527. Short amino acid sequences derived from C1q receptor (C1q-R) show homology with the alpha chains of fibronectin and vitronectin receptors and collagen type IV. (PubMed id 1377218)1 Ghebrehiwet B....Gorevic P.D. (J. Leukoc. Biol. 1992)
    528. Lymphocyte CD44 binds the COOH-terminal heparin-binding domain of fibronectin. (PubMed id 1730778)1 Jalkanen S. and Jalkanen M. (J. Cell Biol. 1992)
    529. Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets. (PubMed id 1715582)1 Huang M.M....Brugge J.S. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    530. von Willebrand factor binding to platelet GpIb initiates signals for platelet activation. (PubMed id 1939645)1 Kroll M.H....Schafer A.I. (J. Clin. Invest. 1991)
    531. Completion of the last half of the structure of the human gene for the Pro alpha 1 (I) chain of type I procollagen (COL1A1). (PubMed id 1787829)1 Westerhausen A....Prockop D.J. (Matrix 1991)
    532. The alpha 2 beta 1 integrin cell surface collagen receptor binds to the alpha 1 (I)-CB3 peptide of collagen. (PubMed id 2156854)1 Staatz W.D....Santoro S.A. (J. Biol. Chem. 1990)
    533. Single base mutation in the type II procollagen gene (COL2A1) as a cause of primary osteoarthritis associated with a mild chondrodysplasia. (PubMed id 1975693)4 Ala-Kokko L.... Prockop D.J. (Proc. Natl. Acad. Sci. U.S.A. 1990)
    534. Isolation of a novel integrin receptor mediating Arg-Gly-Asp-directed cell adhesion to fibronectin and type I collagen from human neuroblastoma cells. Association of a novel beta 1-related subunit with alpha v. (PubMed id 1693626)1 Dedhar S. and Gray V. (J. Cell Biol. 1990)
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    663. Leg pain in an infant. (PubMed id 20034948)9 Haile J.T....Steele R.W. (Clin Pediatr (Phila) 2010)
    664. Response of malignant scalp dermatofibrosarcoma to presurgical targeted growth factor inhibition. (PubMed id 19681684)9 Mattox A.K....Adamson D.C. (J. Neurosurg. 2010)
    665. Investigating the role of P311 in the hypertrophic scar. (PubMed id 20404911)9 Tan J....Wu J. (PLoS ONE 2010)
    666. The COL5A1 gene is associated with increased risk of anterior cruciate ligament ruptures in female participants. (PubMed id 19654427)9 Posthumus M....Collins M. (Am J Sports Med 2009)
    667. A missense mutation in the SERPINH1 gene in Dachshunds with osteogenesis imperfecta. (PubMed id 19629171)9 DrAPgemA1ller C....Leeb T. (PLoS Genet. 2009)
    668. Osteogenesis imperfecta: questions and answers. (PubMed id 19907330)9 Shapiro J.R. and Sponsellor P.D. (Curr. Opin. Pediatr. 2009)
    669. Chondrogenic differentiation of adipose tissue-derived mesenchymal stem cells: greater doses of growth factor are necessary. (PubMed id 18985688)9 Kim H.J. and Im G.I. (J. Orthop. Res. 2009)
    670. Current evidence for a modulation of low back pain by human genetic variants. (PubMed id 19228264)9 Tegeder I. and LAPtsch J. (J. Cell. Mol. Med. 2009)
    671. In vitro differentiation of human calvarial suture derived cells with and without dexamethasone does not induce in vivo-like expression. (PubMed id 18803234)9 Coussens A.K....Anderson P.J. (J. Cell. Physiol. 2009)
    672. cAMP/PKA signaling inhibits osteogenic differentiation and bone formation in rodent models. (PubMed id 19231969)9 Siddappa R....de Boer J. (Tissue Eng Part A 2009)
    673. Differential global and extra-cellular matrix focused gene expression patterns between normal and glaucomatous human lamina cribrosa cells. (PubMed id 19145252)9 Kirwan R.P....O'Brien C.J. (Mol. Vis. 2009)
    674. Influence of an extract from kudzu symbiosomes containing leghemoglobin on in vitro cutaneous procollagen production. (PubMed id 19822105)9 Gruber J.V. and Holtz R. (J Cosmet Sci 2009)
    675. [Molecular diagnosis of a Chinese pedigree with osteogenesis imperfecta type I]. (PubMed id 19199251)9 Ke L.F....Lan F.H. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2009)
    676. Circulating mesenchymal stem cells with abnormal osteogenic differentiation in patients with osteoporosis. (PubMed id 19877060)9 Dalle Carbonare L....Lo Cascio V. (Arthritis Rheum. 2009)
    677. Genetic risk factors for musculoskeletal soft tissue injuries. (PubMed id 19696512)9 Collins M. and Raleigh S.M. (Med Sport Sci 2009)
    678. The small GTPase Rho mediates articular chondrocyte phenotype and morphology in response to interleukin-1alpha and insulin-like growth factor-I. (PubMed id 18634065)9 Novakofski K....Fortier L. (J. Orthop. Res. 2009)
    679. Endothelial to mesenchymal transition via transforming growth factor-beta1/Smad activation is associated with portal venous stenosis in idiopathic portal hypertension. (PubMed id 19608867)9 Kitao A....Nakanuma Y. (Am. J. Pathol. 2009)
    680. Chondrogenic differentiation potential of osteoarthritic chondrocytes and their possible use in matrix-associated autologous chondrocyte transplantation. (PubMed id 19723327)9 Dehne T....Lindahl A. (amp 2009)
    681. Hypoxia-inducible factor 1alpha inhibits the fibroblast-like markers type I and type III collagen during hypoxia-induced chondrocyte redifferentiation: hypoxia not only induces type II collagen and aggrecan, but it also inhibits type I and type III collagen in the hypoxia-inducible factor 1alpha-dependent redifferentiation of chondrocytes. (PubMed id 19790048)9 Duval E....BoumAcdiene K. (Arthritis Rheum. 2009)
    682. [New molecular approaches in dermatofibrosarcoma protuberans]. (PubMed id 19694363)9 Kaya G. (Rev Med Suisse 2009)
    683. Role of miR-29b on the regulation of the extracellular matrix in human trabecular meshwork cells under chronic oxidative stress. (PubMed id 19956414)9 Luna C....Gonzalez P. (Mol. Vis. 2009)
    684. Calvarial doughnut lesions and osteoporosis: a new three-generation family and review. (PubMed id 19839042)9 Jaakkola E....MAokitie O. (Am. J. Med. Genet. A 2009)
    685. Bone morphogenetic proteins are involved in the pathobiology of synovial chondromatosis. (PubMed id 19138670)9 Nakanishi S....Yamaguchi A. (Biochem. Biophys. Res. Commun. 2009)
    686. Connective tissue and related disorders and preterm birth: clues to genes contributing to prematurity. (PubMed id 19152976)9 Anum E.A....Strauss J.F. (Placenta 2009)
    687. A novel COL1A1 gene-splicing mutation (c.1875+1G&gt;C) in a Brazilian patient with osteogenesis imperfecta. (PubMed id 19283684)9 Barbirato C....Paula F. (Genet. Mol. Res. 2009)
    688. [Molecular approach in the treatment of dermatofibrosarcoma protuberans]. (PubMed id 18998038)9 Fattoruso S.I....Lopez M. (Clin Ter 2008)
    689. Se-methylselenocysteine alters collagen gene and protein expression in human prostate cells. (PubMed id 18514395)9 Hurst R....Fairweather-Tait S.J. (Cancer Lett. 2008)
    690. Allele dependent silencing of COL1A2 using small interfering RNAs. (PubMed id 19015742)9 Lindahl K....Ljunggren O. (Int J Med Sci 2008)
    691. Can platelet-rich plasma enhance tendon repair? A cell culture study. (PubMed id 18326832)9 de Mos M....van Osch G.J. (Am J Sports Med 2008)
    692. Compressive forces induce osteogenic gene expression in calvarial osteoblasts. (PubMed id 18191137)9 Rath B....Agarwal S. (J Biomech 2008)
    693. Expression of cartilage-specific markers in calcified and non-calcified atherosclerotic lesions. (PubMed id 17335825)9 Aigner T....Amann K. (Atherosclerosis 2008)
    694. Association of an extracellular matrix gene cluster with breast cancer prognosis and endocrine therapy response. (PubMed id 18765548)9 Helleman J....Berns E.M. (Clin. Cancer Res. 2008)
    695. Biomarker candidates for cardiovascular disease and bone metabolism disorders in chronic kidney disease: a systems biology perspective. (PubMed id 18266955)9 Perco P....Oberbauer R. (J. Cell. Mol. Med. 2008)
    696. Oligodeoxynucleotide decoy therapy blocks type 1 procollagen transcription and the prolyl hydroxylase beta subunit translation. (PubMed id 18027883)9 Lok C.N....Chiu J.F. (J. Cell. Biochem. 2008)
    697. Endothelin-1 mediated regulation of extracellular matrix collagens in cells of human lamina cribrosa. (PubMed id 18420197)9 Rao V.R....Yorio T. (Exp. Eye Res. 2008)
    698. [Screening of differentially expressed genes in human renal cell carcinoma using suppression subtractive hybridization]. (PubMed id 18227036)9 Wang Y....Li X. (Nan Fang Yi Ke Da Xue Xue Bao 2008)
    699. Src kinases in systemic sclerosis: central roles in fibroblast activation and in skin fibrosis. (PubMed id 18438865)9 Skhirtladze C....Distler J.H. (Arthritis Rheum. 2008)
    700. Interface membrane fibroblasts around aseptically loosened endoprostheses express MMP-13. (PubMed id 17853491)9 Wagner S....Hofstetter W. (J. Orthop. Res. 2008)
    701. Pharmacogenetics of osteoporosis and the prospect of individualized prognosis and individualized therapy. (PubMed id 18971675)9 Nguyen T.V....Eisman J.A. (Curr Opin Endocrinol Diabetes Obes 2008)
    702. Correlative gene expression and DNA methylation profiling in lung development nominate new biomarkers in lung cancer. (PubMed id 18203646)9 Cortese R....Eckhardt F. (amp 2008)
    703. Complex t(5;8) involving the CSPG2 and PTK2B genes in a case of dermatofibrosarcoma protuberans without the COL1A1-PDGFB fusion. (PubMed id 18253748)9 Bianchini L....Pedeutour F. (Virchows Arch. 2008)
    704. Different gene expression patterns in the bone tissue of aging postmenopausal osteoporotic and non-osteoporotic women. (PubMed id 18074071)9 Balla B....Lakatos P. (Calcif. Tissue Int. 2008)
    705. Hereditary dentine disorders: dentinogenesis imperfecta and dentine dysplasia. (PubMed id 19021896)9 Barron M.J....Dixon M.J. (Orphanet J Rare Dis 2008)
    706. Connective tissue growth factor modulates extracellular matrix production in human subconjunctival fibroblasts and their proliferation and migration in vitro. (PubMed id 18369694)9 Yamanaka O....Ohnishi Y. (Jpn. J. Ophthalmol. 2008)
    707. Biologic characteristics of fibrous hamartoma from congenital pseudarthrosis of the tibia associated with neurofibromatosis type 1. (PubMed id 19047720)9 Cho T.J....Choi I.H. (J Bone Joint Surg Am 2008)
    708. Mouse model of dermal fibrosis induced by one-time injection of bleomycin-poly(L-lactic acid) microspheres. (PubMed id 18316335)9 Shibusawa Y....Ishikawa O. (Rheumatology (Oxford) 2008)
    709. Topical oxygen therapy induces vascular endothelial growth factor expression and improves closure of clinically presented chronic wounds. (PubMed id 18430064)9 Gordillo G.M....Sen C.K. (amp 2008)
    710. Phenotypic characterization of osteoblasts from the sclerotic zones of osteoarthritic subchondral bone. (PubMed id 18240211)9 Sanchez C....Henrotin Y.E. (Arthritis Rheum. 2008)
    711. Remission with Imatinib mesylate treatment in a patient with initially unresectable dermatofibrosarcoma protuberans--a case report. (PubMed id 18751744)9 Lemm D....Schultze-Mosgau S. (Oral Maxillofac Surg 2008)
    712. Studies of otic capsule morphology and gene expression in the Mov13 mouse--an animal model of type I osteogenesis imperfecta. (PubMed id 17595534)9 Stankovic K.M....McKenna M.J. (amp 2007)
    713. Anatomic and dynamic aspects of stomatognathic structures in osteogenesis imperfecta: a case report. (PubMed id 17508636)9 Ortega A.d.e. .O....Alonso L.G. (Cranio 2007)
    714. Type III collagen is essential for growth acceleration of human osteoblastic cells by ascorbic acid 2-phosphate, a long-acting vitamin C derivative. (PubMed id 17306970)9 Maehata Y....Hata R. (Matrix Biol. 2007)
    715. Anti-fibroblast antibodies detected by cell-based ELISA in systemic sclerosis enhance the collagenolytic activity and matrix metalloproteinase-1 production in dermal fibroblasts. (PubMed id 17982166)9 Fineschi S....Chizzolini C. (Rheumatology (Oxford) 2007)
    716. Therapies for bleomycin induced lung fibrosis through regulation of TGF-beta1 induced collagen gene expression. (PubMed id 17387717)9 Cutroneo K.R....Ehrlich H.P. (J. Cell. Physiol. 2007)
    717. Osteogenesis imperfecta:epidemiology and pathophysiology. (PubMed id 17925189)9 Martin E. and Shapiro J.R. (Curr Osteoporos Rep 2007)
    718. [Oesteogenesis imperfecta--genetics, diagnosis and medical treatment]. (PubMed id 17217883)9 Brixen K.T....Mosekilde L. (Ugeskr. Laeg. 2007)
    719. Imatinib mesylate reduces production of extracellular matrix and prevents development of experimental dermal fibrosis. (PubMed id 17195235)9 Distler J.H....Distler O. (Arthritis Rheum. 2007)
    720. In vitro evidence for a direct antifibrotic role of the immunosuppressive drug mycophenolate mofetil. (PubMed id 17272676)9 Roos N....Verrecchia F. (J. Pharmacol. Exp. Ther. 2007)
    721. Type I collagen gene suppresses tumor growth and invasion of malignant human glioma cells. (PubMed id 17578585)9 Honma K....Ochiya T. (Cancer Cell Int. 2007)
    722. Recent advances in the genetics of osteoporosis. (PubMed id 16675887)9 Williams F.M. and Spector T.D. (amp 2006)
    723. Dermatofibrosarcoma protuberans: a surgical disease with a molecular savior. (PubMed id 16721128)9 McArthur G.A. (Curr Opin Oncol 2006)
    724. Collagen synthesis by mesenchymal stem cells and aortic valve interstitial cells in response to mechanical stretch. (PubMed id 16740254)9 Ku C.H....Chester A.H. (Cardiovasc. Res. 2006)
    725. Targeted therapy for dermatofibrosarcoma protuberans. (PubMed id 17254529)9 Abrams T.A. and Schuetze S.M. (Curr Oncol Rep 2006)
    726. Inhibition of systemic sclerosis dermal fibroblast type I collagen production and gene expression by simvastatin. (PubMed id 16575855)9 Louneva N....JimAcnez S.A. (Arthritis Rheum. 2006)
    727. Antifibrotic effects of antioxidant N-acetylcysteine in a mouse model of human hypertrophic cardiomyopathy mutation. (PubMed id 16487852)9 Marian A.J....Lombardi R. (J. Am. Coll. Cardiol. 2006)
    728. Influence of ACE-inhibition and mechanical unloading on the regulation of extracellular matrix proteins in the myocardium of heart transplantation candidates bridged by ventricular assist devices. (PubMed id 16309954)9 Milting H....KAPrfer R. (Eur. J. Heart Fail. 2006)
    729. [Genetic markers in the pathogenesis of osteopenia and osteoporosis in cystic fibrosis]. (PubMed id 17028393)9 Norek A....Bal J. (Med Wieku Rozwoj 2006)
    730. MCP-1/CCR2-dependent loop for fibrogenesis in human peripheral CD14-positive monocytes. (PubMed id 16415174)9 Sakai N....Kaneko S. (J. Leukoc. Biol. 2006)
    731. Interleukin-7 modulates extracellular matrix production and TGF-beta signaling in cultured human subconjunctival fibroblasts. (PubMed id 16769608)9 Yamanaka O....Ooshima A. (Curr. Eye Res. 2006)
    732. Exclusion mapping of chromosomes 1, 4, 6 and 14 with bone mineral density in 79 Caucasian pedigrees. (PubMed id 16249131)9 Chen X.D....Deng H.W. (Bone 2006)
    733. Monogenic nonsyndromic otosclerosis: audiological and linkage analysis in a large Greek pedigree. (PubMed id 16168495)9 Iliadou V....Petersen M.B. (Int. J. Pediatr. Otorhinolaryngol. 2006)
    734. TEF-1 and C/EBPbeta are major p38alpha MAPK-regulated transcription factors in proliferating cardiomyocytes. (PubMed id 16492136)9 Ambrosino C....Nebreda A.R. (Biochem. J. 2006)
    735. Bone mineral density-affecting genes in Africans. (PubMed id 16895279)9 Gong G....Wilson M.R. (J Natl Med Assoc 2006)
    736. Fli1 and Ets1 have distinct roles in connective tissue growth factor/CCN2 gene regulation and induction of the profibrotic gene program. (PubMed id 16829517)9 Nakerakanti S.S....Trojanowska M. (J. Biol. Chem. 2006)
    737. Total absence of the alpha2(I) chain of collagen type I causes a rare form of Ehlers-Danlos syndrome with hypermobility and propensity to cardiac valvular problems. (PubMed id 16816023)9 Malfait F....De Paepe A. (J. Med. Genet. 2006)
    738. [Gene mutation analysis of a Chinese family with osteogenesis imperfecta]. (PubMed id 16604495)9 Wang Z....Wang L.T. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2006)
    739. The molecular basis of classic Ehlers-Danlos syndrome: a comprehensive study of biochemical and molecular findings in 48 unrelated patients. (PubMed id 15580559)9 Malfait F.... De Paepe A. (Hum. Mutat. 2005)
    740. [Genetic determinants of osteoporosis]. (PubMed id 15789775)9 HubA!cek J.A. and WeichetovA! M. (Cas. Lek. Cesk. 2005)
    741. Liver gene expression signature of mild fibrosis in patients with chronic hepatitis C. (PubMed id 16344072)9 Asselah T....Marcellin P. (Gastroenterology 2005)
    742. Gene polymorphisms as predictors of decreased bone mineral density and osteoporosis in primary biliary cirrhosis. (PubMed id 15716655)9 ParAcs A....RodAcs J. (amp 2005)
    743. NFAT and Osterix cooperatively regulate bone formation. (PubMed id 16041384)9 Koga T....Takayanagi H. (Nat. Med. 2005)
    744. Optimization of high-efficiency transfection of adult human mesenchymal stem cells in vitro. (PubMed id 15805572)9 Haleem-Smith H....Tuan R.S. (Mol. Biotechnol. 2005)
    745. In vitro functional assay of alleles and haplotypes of two COL1A1-promoter SNPs. (PubMed id 15814304)9 GarcA-a-Giralt N....Balcells S. (Bone 2005)
    746. The development and application of imatinib. (PubMed id 15794712)9 Jones R.L. and Judson I.R. (Expert Opin Drug Saf 2005)
    747. Gene variants for osteoporosis and their pleiotropic effects in aging. (PubMed id 15811432)9 Ferrari S.L. and Rizzoli R. (Mol. Aspects Med. 2005)
    748. Procollagen type I gene expression and cell proliferation are increased in lipodermatosclerosis. (PubMed id 15727634)9 Degiorgio-Miller A.M....Herrick S.E. (Br. J. Dermatol. 2005)
    749. Aneurysmal bone cyst variant translocations upregulate USP6 transcription by promoter swapping with the ZNF9, COL1A1, TRAP150, and OMD genes. (PubMed id 15735689)9 Oliveira A.M....Fletcher J.A. (Oncogene 2005)
    750. Transforming growth factor-beta1-induced hypertrophy and matrix expression in human bladder smooth muscle cells. (PubMed id 16360482)9 Howard P.S....He Y. (Urology 2005)
    751. Caffey disease: an unlikely collagenopathy. (PubMed id 15864344)9 Glorieux F.H. (J. Clin. Invest. 2005)
    752. Genetic epidemiology of skeletal system aging in apparently healthy human population. (PubMed id 15621207)9 Livshits G. (Mech. Ageing Dev. 2005)
    753. A mouse model of ethanol dependent pancreatic fibrosis. (PubMed id 15870229)9 Perides G....Steer M.L. (Gut 2005)
    754. Molecular-pathological prognostic factors of gastric cancer: a review. (PubMed id 15864715)9 Yasui W....Nakayama H. (Gastric Cancer 2005)
    755. Reversal of gene expression profile in the phenylketonuria mouse model after adeno-associated virus vector-mediated gene therapy. (PubMed id 16150627)9 Oh H.J....Jung S.C. (Mol. Genet. Metab. 2005)
    756. Syndromes with congenital brittle bones. (PubMed id 15339338)9 Plotkin H. (BMC Pediatr 2004)
    757. A highly reproducible and economically competitive SNP analysis of several well characterized human mutations. (PubMed id 15209439)9 Behrens M. and Lange R. (Clin. Lab. 2004)
    758. Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease. (PubMed id 15469929)9 Ning W....Choi A.M. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    759. Upregulation of the NNP-1 (novel nuclear protein-1, D21S2056E) gene in keloid tissue determined by cDNA microarray and in situ hybridization. (PubMed id 15606508)9 Na G.Y....Kim J.C. (Br. J. Dermatol. 2004)
    760. Patterns of linkage disequilibrium and haplotype distribution in disease candidate genes. (PubMed id 15157284)9 Long J.R....Deng H.W. (BMC Genet. 2004)
    761. Association between osteoporosis and otosclerosis in women. (PubMed id 15453937)9 Clayton A.E....McKenna M.J. (J Laryngol Otol 2004)
    762. Mammalian target of rapamycin positively regulates collagen type I production via a phosphatidylinositol 3-kinase-independent pathway. (PubMed id 15047702)9 Shegogue D. and Trojanowska M. (J. Biol. Chem. 2004)
    763. Induction and reversal of cardiac phenotype of human hypertrophic cardiomyopathy mutation cardiac troponin T-Q92 in switch on-switch off bigenic mice. (PubMed id 15582321)9 Lutucuta S....Marian A.J. (J. Am. Coll. Cardiol. 2004)
    764. Aldosterone, through novel signaling proteins, is a fundamental molecular bridge between the genetic defect and the cardiac phenotype of hypertrophic cardiomyopathy. (PubMed id 14993121)9 Tsybouleva N....Marian A.J. (Circulation 2004)
    765. Impact of genetic variation on metabolic response of bone to diet. (PubMed id 15018490)9 Cusack S. and Cashman K.D. (Proc Nutr Soc 2003)
    766. [Detection of COL1A1/PDGFB fusion transcripts in dermatofibroscoma protuberans by revers transcriptase-polymerase chain reaction using paraffin-embedded tissues]. (PubMed id 14633450)9 Yang J.H....Dang H.W. (Zhonghua Bing Li Xue Za Zhi 2003)
    767. Modulation of transforming growth factor-beta (TGF-beta) signaling by endogenous sphingolipid mediators. (PubMed id 12515830)9 Sato M....Trojanowska M. (J. Biol. Chem. 2003)
    768. Osteoporosis: genetic analysis of multifactorial disease. (PubMed id 12916320)9 Zajickova K. and Zofkova I. (Endocr Regul 2003)
    769. Sequence variations in the collagen IX and XI genes are associated with degenerative lumbar spinal stenosis. (PubMed id 14644861)9 Noponen-Hietala N....Ala-Kokko L. (Ann. Rheum. Dis. 2003)
    770. Is the Sp1 polymorphism in the COL1A1 gene a risk factor for postmenopausal osteoporosis? Comment on the article by Keen et al. (PubMed id 12384955)9 ZajA-ckovA! K....Hill M. (Arthritis Rheum. 2002)
    771. Single nucleotide polymorphism detection: allelic discrimination using TaqMan. (PubMed id 12218656)9 McGuigan F.E. and Ralston S.H. (Psychiatr. Genet. 2002)
    772. Low oxygen tension stimulates collagen synthesis and COL1A1 transcription through the action of TGF-beta1. (PubMed id 11920680)9 Falanga V....Yufit T. (J. Cell. Physiol. 2002)
    773. Homozygous Gly530Ser substitution in COL5A1 causes mild classical Ehlers-Danlos syndrome. (PubMed id 11992482)9 Giunta C....Steinmann B. (Am. J. Med. Genet. 2002)
    774. Rapid and efficient genotype analysis of the COL1a1 Sp1 binding site dimorphism, a genetic marker for bone mineral density. (PubMed id 12005451)9 Mirandola S....Mottes M. (Mol. Cell. Probes 2002)
    775. Validation in mesenchymal progenitor cells of a mutation-independent ex vivo approach to gene therapy for osteogenesis imperfecta. (PubMed id 12217948)9 Millington-Ward S....Farrar G.J. (Hum. Mol. Genet. 2002)
    776. A single amino acid substitution (D1441Y) in the carboxyl-terminal propeptide of the proalpha1(I) chain of type I collagen results in a lethal variant of osteogenesis imperfecta with features of dense bone diseases. (PubMed id 11826020)9 Pace J.M....Byers P.H. (J. Med. Genet. 2002)
    777. Molecular anatomy of an intracranial aneurysm: coordinated expression of genes involved in wound healing and tissue remodeling. (PubMed id 11283408)9 Peters D.G....Brufsky A. ( a journal of cerebral circulation 2001)
    778. Blocking sp1 transcription factor broadly inhibits extracellular matrix gene expression in vitro and in vivo: implications for the treatment of tissue fibrosis. (PubMed id 11348466)9 Verrecchia F....Mauviel A. (J. Invest. Dermatol. 2001)
    779. Structural and functional analysis of a chimeric protein COL1A1-PDGFB generated by the translocation t(17;22)(q22;q13.1) in Dermatofibrosarcoma protuberans (DP). (PubMed id 11420709)9 Simon M.P....PouyssAcgur J. (Oncogene 2001)
    780. Fibroblasts from idiopathic pulmonary fibrosis and normal lungs differ in growth rate, apoptosis, and tissue inhibitor of metalloproteinases expression. (PubMed id 11350829)9 Ramos C....Pardo A. (Am. J. Respir. Cell Mol. Biol. 2001)
    781. [Genetics of osteoporosis]. (PubMed id 11515178)9 GAPrtz B. and Fassbender W.J. (Orthopade 2001)
    782. Concomitant DNA copy number amplification at 17q and 22q in dermatofibrosarcoma protuberans. (PubMed id 11435686)9 Kiuru-Kuhlefelt S....Knuutila S. (Cytogenet. Cell Genet. 2001)
    783. Birthweight, vitamin D receptor genotype and the programming of osteoporosis. (PubMed id 11489147)9 Dennison E.M....Cooper C. (Paediatr Perinat Epidemiol 2001)
    784. Gap-junctional communication is required for the maturation process of osteoblastic cells in culture. (PubMed id 11336916)9 Schiller P.C....Howard G.A. (Bone 2001)
    785. A COL1A1 Sp1 binding site polymorphism predisposes to osteoporotic fracture by affecting bone density and quality. (PubMed id 11285309)9 Mann V....Ralston S.H. (J. Clin. Invest. 2001)
    786. Partial COL1A2 gene duplication produces features of osteogenesis imperfecta and Ehlers-Danlos syndrome type VII. (PubMed id 10982177)9 Raff M.L....Byers P.H. (Hum. Genet. 2000)
    787. Prenatal diagnosis of a novel COL1A1 mutation in osteogenesis imperfecta type I carried through full term pregnancy. (PubMed id 11113887)9 Ries L....Friedman E. (Prenat. Diagn. 2000)
    788. [Mutations of genes coding collagen type I--biochemical and clinical effects]. (PubMed id 10803027)9 Wieczorek P....Rzeuski R. (Postepy Hig Med Dosw 2000)
    789. Two pregnancies after preimplantation genetic diagnosis for osteogenesis imperfecta type I and type IV. (PubMed id 10942108)9 De Vos A....Van Steirteghem A. (Hum. Genet. 2000)
    790. Bone resorption induced by parathyroid hormone is strikingly diminished in collagenase-resistant mutant mice. (PubMed id 10021460)9 Zhao W....Krane S.M. (J. Clin. Invest. 1999)
    791. Developmental expression analysis of murine autotaxin (ATX). (PubMed id 10473125)9 BAochner D....Gross G. (Mech. Dev. 1999)
    792. Regulation of lysyl oxidase, collagen, and connective tissue growth factor by TGF-beta1 and detection in human gingiva. (PubMed id 10616214)9 Hong H.H....Trackman P.C. ( a journal of technical methods and pathology 1999)
    793. Genetic aspects of osteoporosis. (PubMed id 10411385)9 Ferrari S....Bonjour J.P. (Curr Opin Rheumatol 1999)
    794. Reliable and sensitive detection of premature termination mutations using a protein truncation test designed to overcome problems of nonsense-mediated mRNA instability. (PubMed id 10220145)9 Bateman J.F....Forrest S. (Hum. Mutat. 1999)
    795. Alterations in the regulation of expression of the alpha 1(I) collagen gene (COL1A1) in systemic sclerosis (scleroderma). (PubMed id 10945033)9 Jimenez S.A. and Saitta B. (Springer Semin. Immunopathol. 1999)
    796. Redefinition of exon 7 in the COL1A1 gene of type I collagen by an intron 8 splice-donor-site mutation in a form of osteogenesis imperfecta: influence of intron splice order on outcome of splice-site mutation. (PubMed id 10417276)9 Schwarze U....Byers P.H. (Am. J. Hum. Genet. 1999)
    797. A patient with Ehlers-Danlos syndrome type VI is homozygous for a premature termination codon in exon 14 of the lysyl hydroxylase 1 gene. (PubMed id 10329027)9 Walker L.C....Yeowell H.N. (Mol. Genet. Metab. 1999)
    798. Osteogenesis imperfecta. (PubMed id 9682085)9 Kocher M.S. and Shapiro F. (J Am Acad Orthop Surg 1998)
    799. [Hereditary diseases with tooth anomalies and their causal genes]. (PubMed id 9711025)9 Kurisu K. and Tabata M.J. (Kaibogaku Zasshi 1998)
    800. Role of EP2 receptors and cAMP in prostaglandin E2 regulated expression of type I collagen alpha1, lysyl oxidase, and cyclooxygenase-1 genes in human embryo lung fibroblasts. (PubMed id 9779823)9 Choung J....Polgar P. (J. Cell. Biochem. 1998)
    801. An Sp1 binding site polymorphism in the COLIA1 gene predicts osteoporotic fractures in both men and women. (PubMed id 9738510)9 Langdahl B.L....Eriksen E.F. (J. Bone Miner. Res. 1998)

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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1277 HGNC: 2197 AceView: COL1A1 Ensembl:ENSG00000108821 euGenes: HUgn1277
    ECgene: COL1A1 Kegg: 1277 H-InvDB: COL1A1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for COL1A1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for COL1A1 Genetics and Cytogenetics in Oncology and Haematology
    Osteogenesis imperfecta variant databasehttp://oi.gene.le.ac.uk/home.php?select_db=COL1A1
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=COL1A1[genesymbol]
    Wikipedia http://en.wikipedia.org/wiki/Type-I_collagen

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for COL1A1 gene:
    Search GeneIP for patents involving COL1A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     EMD Millipore Mono- and Polyclonal Antibodies for the study of COL1A1
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     PureStem Progenitors for COL1A1: PureStem 7PEND24, NCr-fac & Meso-prx Progenitor, PureStem 7SMOO32, NCr-fac & Meso Progenitor,
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     antibodies-online antibodies for COL1A1 (34 products)
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